TAF1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.60082375
2mannose metabolic process (GO:0006013)5.33381220
3DNA deamination (GO:0045006)4.73733994
4viral transcription (GO:0019083)4.49776854
5formation of translation preinitiation complex (GO:0001731)4.49357438
6maturation of SSU-rRNA (GO:0030490)4.42847404
7ribosomal small subunit assembly (GO:0000028)4.38860723
8translational termination (GO:0006415)4.37330196
9nucleobase biosynthetic process (GO:0046112)4.31258062
10translational elongation (GO:0006414)4.01550750
11purine nucleobase biosynthetic process (GO:0009113)4.01293199
12DNA strand elongation involved in DNA replication (GO:0006271)4.01167172
13translational initiation (GO:0006413)4.00825458
14regulation of ARF GTPase activity (GO:0032312)3.91592879
15semaphorin-plexin signaling pathway (GO:0071526)3.90015640
16ribosomal small subunit biogenesis (GO:0042274)3.87095277
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.78735159
18DNA unwinding involved in DNA replication (GO:0006268)3.77675673
19DNA strand elongation (GO:0022616)3.77113821
20positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.74768275
21ribosome biogenesis (GO:0042254)3.74672784
22protein localization to kinetochore (GO:0034501)3.73756122
23DNA replication initiation (GO:0006270)3.71589896
24ribonucleoprotein complex biogenesis (GO:0022613)3.69089658
25telomere maintenance via semi-conservative replication (GO:0032201)3.68340467
26ribosomal large subunit biogenesis (GO:0042273)3.65727830
27ribosome assembly (GO:0042255)3.65602110
28IMP biosynthetic process (GO:0006188)3.62266407
29histone H4 deacetylation (GO:0070933)3.62173293
30response to muramyl dipeptide (GO:0032495)3.59376527
31thymic T cell selection (GO:0045061)3.58368627
32negative regulation of cell size (GO:0045792)3.56631849
33mitotic nuclear envelope disassembly (GO:0007077)3.51974500
34regulation of histone H3-K27 methylation (GO:0061085)3.50283220
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.50254853
36apoptotic process involved in morphogenesis (GO:0060561)3.49690440
37DNA replication checkpoint (GO:0000076)3.46563248
38rRNA processing (GO:0006364)3.45446096
39cellular protein complex disassembly (GO:0043624)3.44341570
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.43643094
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.42821843
42protein targeting to ER (GO:0045047)3.39405879
43cotranslational protein targeting to membrane (GO:0006613)3.39173381
44viral life cycle (GO:0019058)3.36485270
45rRNA metabolic process (GO:0016072)3.35031543
46negative regulation of RNA splicing (GO:0033119)3.33765608
47IMP metabolic process (GO:0046040)3.30142216
48positive regulation of histone deacetylation (GO:0031065)3.29420159
49nuclear envelope disassembly (GO:0051081)3.24232772
50membrane disassembly (GO:0030397)3.24232772
51establishment of protein localization to endoplasmic reticulum (GO:0072599)3.24154958
52protein complex disassembly (GO:0043241)3.23459395
53protein localization to chromosome, centromeric region (GO:0071459)3.21505255
54adherens junction assembly (GO:0034333)3.20519261
55telomere maintenance via recombination (GO:0000722)3.17811150
56histone H3 deacetylation (GO:0070932)3.17470543
57folic acid-containing compound biosynthetic process (GO:0009396)3.16248438
58protein localization to endoplasmic reticulum (GO:0070972)3.14814140
59positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.14208582
60planar cell polarity pathway involved in neural tube closure (GO:0090179)3.13486958
61positive thymic T cell selection (GO:0045059)3.12889310
62folic acid metabolic process (GO:0046655)3.12773105
63antigen processing and presentation of endogenous antigen (GO:0019883)3.09636246
64mitotic metaphase plate congression (GO:0007080)3.09454064
65activation of Rac GTPase activity (GO:0032863)3.09452488
66cell-substrate adherens junction assembly (GO:0007045)3.05956268
67focal adhesion assembly (GO:0048041)3.05956268
68response to laminar fluid shear stress (GO:0034616)3.04992535
69positive regulation of protein kinase C signaling (GO:0090037)3.04625926
70pseudouridine synthesis (GO:0001522)3.04251302
71positive regulation of Cdc42 GTPase activity (GO:0043089)3.03631511
72telomere maintenance via telomere lengthening (GO:0010833)3.03395583
73macromolecular complex disassembly (GO:0032984)3.01742572
74positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.00830829
753-UTR-mediated mRNA stabilization (GO:0070935)2.98752069
76nuclear-transcribed mRNA catabolic process (GO:0000956)2.98152512
77negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.98024565
78activation of MAPKKK activity (GO:0000185)2.97360540
79regulation of translational termination (GO:0006449)2.95307625
80NIK/NF-kappaB signaling (GO:0038061)2.93986193
81regulation of translational fidelity (GO:0006450)2.93650123
82regulation of NFAT protein import into nucleus (GO:0051532)2.93393477
83mitotic recombination (GO:0006312)2.93112992
84germinal center formation (GO:0002467)2.92806288
85regulation of type I interferon-mediated signaling pathway (GO:0060338)2.92719431
86intracellular estrogen receptor signaling pathway (GO:0030520)2.92647560
87activation of JUN kinase activity (GO:0007257)2.92634969
88negative regulation of mRNA processing (GO:0050686)2.90255401
89regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.89787964
90DNA replication-dependent nucleosome organization (GO:0034723)2.89460567
91DNA replication-dependent nucleosome assembly (GO:0006335)2.89460567
92regulation of extracellular matrix disassembly (GO:0010715)2.87221584
93COPI coating of Golgi vesicle (GO:0048205)2.87108594
94Golgi transport vesicle coating (GO:0048200)2.87108594
95ncRNA 3-end processing (GO:0043628)2.86779322
96spliceosomal snRNP assembly (GO:0000387)2.86770319
97negative regulation of translational initiation (GO:0045947)2.86550953
98RNA catabolic process (GO:0006401)2.85476480
99maternal placenta development (GO:0001893)2.84813800
100mitotic sister chromatid segregation (GO:0000070)2.83963094
101mRNA catabolic process (GO:0006402)2.83950044
102nuclear pore organization (GO:0006999)2.82918352
103pre-miRNA processing (GO:0031054)2.81812317
104regulation of spindle organization (GO:0090224)2.81795042
105endothelial cell chemotaxis (GO:0035767)2.81465144
106DNA duplex unwinding (GO:0032508)2.81034490
107DNA geometric change (GO:0032392)2.79432188
108RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.79423010
109mRNA splicing, via spliceosome (GO:0000398)2.79423010
110RNA splicing, via transesterification reactions (GO:0000375)2.78733557
111translation (GO:0006412)2.78671840
112negative regulation of histone methylation (GO:0031061)2.78560549
113atrioventricular valve morphogenesis (GO:0003181)2.78413249
114regulation of translation in response to stress (GO:0043555)2.78146963
115T cell selection (GO:0045058)2.77857850
116embryonic process involved in female pregnancy (GO:0060136)2.77841422
117cell-cell junction maintenance (GO:0045217)2.76510200
118regulation of gamma-delta T cell activation (GO:0046643)2.74829615
119antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.74040780
120antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.74040780
121negative regulation of cell killing (GO:0031342)2.74019702
122negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.74019702
123histone H3-K9 demethylation (GO:0033169)2.73975384
124epithelial cell differentiation involved in prostate gland development (GO:0060742)2.73278565
125nuclear envelope organization (GO:0006998)2.73209288
126peptidyl-tyrosine autophosphorylation (GO:0038083)2.71198885
127regulation of gamma-delta T cell differentiation (GO:0045586)2.70043306
128negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.69556416
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.68109928
130nuclear pore complex assembly (GO:0051292)2.67573904
131somatic diversification of immune receptors via somatic mutation (GO:0002566)2.66753455
132somatic hypermutation of immunoglobulin genes (GO:0016446)2.66753455
133snRNA metabolic process (GO:0016073)2.66629786
134regulation of glucose import in response to insulin stimulus (GO:2001273)2.66462824
135negative regulation of mRNA metabolic process (GO:1903312)2.66197028
136signal complex assembly (GO:0007172)2.66102642
137retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.65996614
138negative regulation of myotube differentiation (GO:0010832)2.65563053
139negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.64566095
140metaphase plate congression (GO:0051310)2.64017038
141histone H3-K36 demethylation (GO:0070544)2.62848276
142mitotic G1 DNA damage checkpoint (GO:0031571)2.62842375
143tRNA methylation (GO:0030488)2.62546834
144positive regulation of blood vessel endothelial cell migration (GO:0043536)2.61245630
145regulation of histone H3-K9 methylation (GO:0051570)2.60617063
146poly(A)+ mRNA export from nucleus (GO:0016973)2.60181400
147positive regulation of gamma-delta T cell activation (GO:0046645)2.59963222
148negative regulation of chromosome segregation (GO:0051985)2.59886566
149histone H2A acetylation (GO:0043968)2.59825090
150negative regulation of granulocyte differentiation (GO:0030853)2.59239343
151regulation of monocyte differentiation (GO:0045655)2.58477175
152termination of RNA polymerase II transcription (GO:0006369)2.58003888
153snRNA processing (GO:0016180)2.57871594
154ncRNA processing (GO:0034470)2.57615909
155mitotic chromosome condensation (GO:0007076)2.57531293
156retrograde transport, endosome to Golgi (GO:0042147)2.57355439
157base-excision repair (GO:0006284)2.56742313
158DNA replication-independent nucleosome organization (GO:0034724)2.56733474
159DNA replication-independent nucleosome assembly (GO:0006336)2.56733474
160regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.56567514
161cellular response to virus (GO:0098586)2.56311863
162response to peptidoglycan (GO:0032494)2.55956871
163T cell apoptotic process (GO:0070231)2.55152463
164anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.55088888
165regulation of ARF protein signal transduction (GO:0032012)2.54013681
166modulation by virus of host process (GO:0019054)2.53866485
167positive regulation of protein deacetylation (GO:0090312)2.53799308
168transcription-coupled nucleotide-excision repair (GO:0006283)2.52299676
169cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.51999262
170regulation of chromatin binding (GO:0035561)2.51483088
171basement membrane organization (GO:0071711)2.47887730
172modulation by symbiont of host cellular process (GO:0044068)2.46920744
173entrainment of circadian clock by photoperiod (GO:0043153)2.46916916
174histone lysine demethylation (GO:0070076)2.46035998
175regulation of mammary gland epithelial cell proliferation (GO:0033599)2.44755588
176negative regulation of interleukin-2 production (GO:0032703)2.44047873
177negative regulation of viral release from host cell (GO:1902187)2.41956848
178antigen processing and presentation via MHC class Ib (GO:0002475)2.41657308
179detection of bacterium (GO:0016045)2.41274133
180insulin-like growth factor receptor signaling pathway (GO:0048009)2.39101119
181negative thymic T cell selection (GO:0045060)2.37340056
182cell volume homeostasis (GO:0006884)2.35547118
183vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.34216655
184positive regulation of Rap GTPase activity (GO:0032854)2.33952986
185regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.32133790
186regulation of necroptotic process (GO:0060544)2.31771756
187leukocyte aggregation (GO:0070486)2.31054451
188cytoskeletal anchoring at plasma membrane (GO:0007016)2.30950916
189positive regulation of CREB transcription factor activity (GO:0032793)2.30729452
190histone demethylation (GO:0016577)2.30270178
191cell-substrate junction assembly (GO:0007044)2.29646682
192positive regulation of receptor recycling (GO:0001921)2.29553708
193cellular response to epidermal growth factor stimulus (GO:0071364)2.29383870
194regulation of lipid kinase activity (GO:0043550)2.28998756
195activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.28898122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.56528046
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.73829554
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.69484288
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.21975642
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.14726273
6LXR_22292898_ChIP-Seq_THP-1_Human2.93331896
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84416256
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.80749173
9* MYC_22102868_ChIP-Seq_BL_Human2.75910009
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66406703
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.56738463
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.54428283
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53045917
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44985576
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40384941
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.39336614
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37191867
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30400611
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.27442112
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.26654073
21RACK7_27058665_Chip-Seq_MCF-7_Human2.21277777
22XRN2_22483619_ChIP-Seq_HELA_Human2.19729909
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.19690075
24* GABP_17652178_ChIP-ChIP_JURKAT_Human2.16214930
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13137909
26VDR_21846776_ChIP-Seq_THP-1_Human2.02746685
27VDR_23849224_ChIP-Seq_CD4+_Human2.02388348
28* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02288331
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98421039
30CIITA_25753668_ChIP-Seq_RAJI_Human1.97466244
31KDM2B_26808549_Chip-Seq_K562_Human1.94723220
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91891765
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91591184
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.88677716
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.82022125
36* P68_20966046_ChIP-Seq_HELA_Human1.80371536
37FOXP3_21729870_ChIP-Seq_TREG_Human1.79380607
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77791947
39* GABP_19822575_ChIP-Seq_HepG2_Human1.77073627
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70996722
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.69981360
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69112969
43* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.68706506
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66726098
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66686648
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66540322
47DCP1A_22483619_ChIP-Seq_HELA_Human1.65150182
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.64137740
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.64061917
50KDM2B_26808549_Chip-Seq_JURKAT_Human1.63007919
51SMC4_20622854_ChIP-Seq_HELA_Human1.62422739
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62390329
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.61528245
54TTF2_22483619_ChIP-Seq_HELA_Human1.61184137
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.60227564
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58636951
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57624357
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57357605
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57069627
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.56935803
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56426494
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55963188
63* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55805482
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55326497
65AR_21909140_ChIP-Seq_LNCAP_Human1.52358221
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.50570611
67KDM5A_27292631_Chip-Seq_BREAST_Human1.50428490
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50274571
69CREB1_26743006_Chip-Seq_LNCaP_Human1.48386839
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47965143
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46703997
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45768760
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43713335
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42681630
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41110387
76ZNF263_19887448_ChIP-Seq_K562_Human1.41047294
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40260704
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40244301
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38640117
80* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37992338
81NCOR1_26117541_ChIP-Seq_K562_Human1.37778838
82* RUNX1_27514584_Chip-Seq_MCF-7_Human1.35979748
83* ELF1_20517297_ChIP-Seq_JURKAT_Human1.34587590
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33257489
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31704406
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31416173
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31368277
88ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30509571
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29731012
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29053761
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28769253
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.28733364
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28548629
94BCOR_27268052_Chip-Seq_Bcells_Human1.28385286
95MAF_26560356_Chip-Seq_TH1_Human1.28087288
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27631890
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27419581
98UTX_26944678_Chip-Seq_JUKART_Human1.27330870
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26369781
100* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26015887
101SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25877439
102SPI1_23547873_ChIP-Seq_NB4_Human1.25362683
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25272464
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23978640
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23874509
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22970362
107TFEB_21752829_ChIP-Seq_HELA_Human1.22727638
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22339508
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22175784
110BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21592963
111BCL6_27268052_Chip-Seq_Bcells_Human1.21592654
112HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21414017
113P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20857785
114CTCF_27219007_Chip-Seq_Bcells_Human1.20612548
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18446862
116TCF7_22412390_ChIP-Seq_EML_Mouse1.18132339
117ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17895237
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17749771
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17615986
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16345251
121PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15277300
122CLOCK_20551151_ChIP-Seq_293T_Human1.14734537
123MAF_26560356_Chip-Seq_TH2_Human1.13527376
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11268622
125TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11033904
126ELK3_25401928_ChIP-Seq_HUVEC_Human1.10868070
127* GATA1_19941827_ChIP-Seq_MEL_Mouse1.10532301
128MYB_26560356_Chip-Seq_TH2_Human1.10515509
129MYB_26560356_Chip-Seq_TH1_Human1.10238122
130RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09944115
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09810929
132KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09772994
133NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09662816
134* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08262931
135SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08188420
136CTCF_26484167_Chip-Seq_Bcells_Mouse1.07800809
137RARB_24833708_ChIP-Seq_LIVER_Mouse1.06610806
138ESR1_21235772_ChIP-Seq_MCF-7_Human1.06465048
139PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06318829
140KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06103671
141E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05899020
142MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05801278
143TP53_22127205_ChIP-Seq_IMR90_Human1.05581763
144SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05446685
145GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05431845
146* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05341776
147MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04854397
148POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04333786
149SCL_19346495_ChIP-Seq_HPC-7_Human1.04211938
150IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03553806
151MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02992064
152PHF8_20622854_ChIP-Seq_HELA_Human1.02168338
153NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02042214
154BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00919990
155CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00838899
156ELK1_19687146_ChIP-ChIP_HELA_Human1.00602590
157RUNX1_22412390_ChIP-Seq_EML_Mouse1.00496083
158RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00397374
159* TP63_22573176_ChIP-Seq_HFKS_Human1.00240603
160DROSHA_22980978_ChIP-Seq_HELA_Human0.99105515
161NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98575709
162CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98441644
163KDM2B_26808549_Chip-Seq_DND41_Human0.98381408
164SPI1_23127762_ChIP-Seq_K562_Human0.98188044
165GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97914525
166SRF_21415370_ChIP-Seq_HL-1_Mouse0.97416734
167VDR_24763502_ChIP-Seq_THP-1_Human0.97037840
168SA1_27219007_Chip-Seq_Bcells_Human0.97025964
169RARA_24833708_ChIP-Seq_LIVER_Mouse0.96897454
170E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96601305
171KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95892303
172SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95786149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.91251303
2MP0003705_abnormal_hypodermis_morpholog4.03917130
3MP0003111_abnormal_nucleus_morphology3.86570637
4MP0004957_abnormal_blastocyst_morpholog3.66314824
5MP0002396_abnormal_hematopoietic_system3.49703020
6MP0005058_abnormal_lysosome_morphology3.46923057
7MP0003077_abnormal_cell_cycle3.46114611
8MP0003172_abnormal_lysosome_physiology3.32931841
9MP0010094_abnormal_chromosome_stability3.32335970
10MP0008057_abnormal_DNA_replication3.15312509
11MP0008058_abnormal_DNA_repair2.63895589
12MP0005409_darkened_coat_color2.43847404
13MP0003763_abnormal_thymus_physiology2.37830848
14MP0009333_abnormal_splenocyte_physiolog2.33803023
15MP0005397_hematopoietic_system_phenotyp2.28116188
16MP0001545_abnormal_hematopoietic_system2.28116188
17MP0004808_abnormal_hematopoietic_stem2.16174112
18MP0000490_abnormal_crypts_of2.14349808
19MP0001730_embryonic_growth_arrest2.11268223
20MP0010352_gastrointestinal_tract_polyps2.10509334
21MP0005451_abnormal_body_composition2.08472295
22MP0009278_abnormal_bone_marrow2.06069703
23MP0000685_abnormal_immune_system2.05801013
24MP0002398_abnormal_bone_marrow2.05351282
25MP0001348_abnormal_lacrimal_gland2.01720678
26MP0000350_abnormal_cell_proliferation2.00519679
27MP0008007_abnormal_cellular_replicative2.00298928
28MP0004381_abnormal_hair_follicle1.99969356
29MP0004858_abnormal_nervous_system1.97989277
30MP0000678_abnormal_parathyroid_gland1.97965923
31MP0002249_abnormal_larynx_morphology1.93796099
32MP0010307_abnormal_tumor_latency1.92210709
33MP0000703_abnormal_thymus_morphology1.85264648
34MP0005666_abnormal_adipose_tissue1.80238645
35MP0002722_abnormal_immune_system1.78208809
36MP0001800_abnormal_humoral_immune1.73909185
37MP0001835_abnormal_antigen_presentation1.73898323
38MP0000689_abnormal_spleen_morphology1.73064214
39MP0003300_gastrointestinal_ulcer1.72709910
40MP0008932_abnormal_embryonic_tissue1.67634563
41MP0003453_abnormal_keratinocyte_physiol1.67507416
42MP0005671_abnormal_response_to1.62800238
43MP0000716_abnormal_immune_system1.60557757
44MP0002933_joint_inflammation1.59288278
45MP0003091_abnormal_cell_migration1.56912891
46MP0005375_adipose_tissue_phenotype1.56574632
47MP0002019_abnormal_tumor_incidence1.56416287
48MP0000313_abnormal_cell_death1.56069466
49MP0003279_aneurysm1.55911794
50MP0002429_abnormal_blood_cell1.54947835
51MP0001873_stomach_inflammation1.51203685
52MP0009384_cardiac_valve_regurgitation1.50637533
53MP0002080_prenatal_lethality1.48853727
54MP0002420_abnormal_adaptive_immunity1.48639362
55MP0005076_abnormal_cell_differentiation1.48045751
56MP0000003_abnormal_adipose_tissue1.48020352
57MP0001819_abnormal_immune_cell1.46449659
58MP0002723_abnormal_immune_serum1.46286275
59MP0002452_abnormal_antigen_presenting1.45441084
60MP0001697_abnormal_embryo_size1.42789799
61MP0005380_embryogenesis_phenotype1.41487054
62MP0001672_abnormal_embryogenesis/_devel1.41487054
63MP0003786_premature_aging1.39733905
64MP0003436_decreased_susceptibility_to1.39689635
65MP0003566_abnormal_cell_adhesion1.39114053
66MP0002796_impaired_skin_barrier1.39046324
67MP0003303_peritoneal_inflammation1.38771953
68MP0000465_gastrointestinal_hemorrhage1.37816230
69MP0002405_respiratory_system_inflammati1.37219565
70MP0000751_myopathy1.34386757
71MP0008260_abnormal_autophagy1.31603870
72MP0008877_abnormal_DNA_methylation1.29536205
73MP0003984_embryonic_growth_retardation1.29114794
74MP0001790_abnormal_immune_system1.28966003
75MP0005387_immune_system_phenotype1.28966003
76MP0003191_abnormal_cellular_cholesterol1.28785578
77MP0005000_abnormal_immune_tolerance1.27015076
78MP0002088_abnormal_embryonic_growth/wei1.26725200
79MP0003123_paternal_imprinting1.25742304
80MP0002089_abnormal_postnatal_growth/wei1.24927633
81MP0002254_reproductive_system_inflammat1.24287640
82MP0003866_abnormal_defecation1.23931923
83MP0001533_abnormal_skeleton_physiology1.22862264
84MP0002086_abnormal_extraembryonic_tissu1.18587107
85MP0002998_abnormal_bone_remodeling1.17467390
86MP0010155_abnormal_intestine_physiology1.16735348
87MP0000358_abnormal_cell_content/1.16378552
88MP0001958_emphysema1.16209484
89MP0002085_abnormal_embryonic_tissue1.15980695
90MP0000767_abnormal_smooth_muscle1.15363029
91MP0006054_spinal_hemorrhage1.13782687
92MP0005025_abnormal_response_to1.12786358
93MP0000858_altered_metastatic_potential1.11164469
94MP0002084_abnormal_developmental_patter1.10332053
95MP0004197_abnormal_fetal_growth/weight/1.04898758
96MP0002877_abnormal_melanocyte_morpholog1.03622060
97MP0003183_abnormal_peptide_metabolism1.02377861
98MP0004947_skin_inflammation1.01567459
99MP0001853_heart_inflammation1.00950576
100MP0009840_abnormal_foam_cell1.00865885
101MP0004264_abnormal_extraembryonic_tissu1.00055877
102MP0006138_congestive_heart_failure0.99983598
103MP0003690_abnormal_glial_cell0.98956832
104MP0009785_altered_susceptibility_to0.98142518
105MP0003567_abnormal_fetal_cardiomyocyte0.97406313
106MP0000733_abnormal_muscle_development0.97361888
107MP0002166_altered_tumor_susceptibility0.97022254
108MP0002132_abnormal_respiratory_system0.95002704
109MP0003724_increased_susceptibility_to0.94010764
110MP0005501_abnormal_skin_physiology0.93952165
111MP0005360_urolithiasis0.93522829
112MP0005670_abnormal_white_adipose0.92078876
113MP0008438_abnormal_cutaneous_collagen0.91059844
114MP0010630_abnormal_cardiac_muscle0.89405684
115MP0005390_skeleton_phenotype0.88936365
116MP0005621_abnormal_cell_physiology0.88221694
117MP0005464_abnormal_platelet_physiology0.88194864
118MP0000477_abnormal_intestine_morphology0.87820609
119MP0001851_eye_inflammation0.87429256
120MP0009931_abnormal_skin_appearance0.85986660
121MP0003656_abnormal_erythrocyte_physiolo0.85218958
122MP0005174_abnormal_tail_pigmentation0.85091363
123MP0005384_cellular_phenotype0.84353302
124MP0003718_maternal_effect0.84234391
125MP0001849_ear_inflammation0.84051092
126MP0002653_abnormal_ependyma_morphology0.83859057
127MP0001293_anophthalmia0.83587610
128MP0005023_abnormal_wound_healing0.83242178
129MP0001145_abnormal_male_reproductive0.82362467
130MP0001845_abnormal_inflammatory_respons0.81521090
131MP0003329_amyloid_beta_deposits0.80244251
132MP0010234_abnormal_vibrissa_follicle0.79810499
133MP0002060_abnormal_skin_morphology0.79182984
134MP0004510_myositis0.78857807
135MP0002970_abnormal_white_adipose0.78096463
136MP0003115_abnormal_respiratory_system0.77394247
137MP0002210_abnormal_sex_determination0.77176777
138MP0003221_abnormal_cardiomyocyte_apopto0.75216410
139MP0002006_tumorigenesis0.74357569
140MP0008770_decreased_survivor_rate0.72742195
141MP0005075_abnormal_melanosome_morpholog0.71921647
142MP0005310_abnormal_salivary_gland0.70514587
143MP0000013_abnormal_adipose_tissue0.69936486
144MP0002419_abnormal_innate_immunity0.69512318
145MP0002925_abnormal_cardiovascular_devel0.68239855
146MP0000249_abnormal_blood_vessel0.67928635
147MP0008874_decreased_physiological_sensi0.67447276
148MP0003448_altered_tumor_morphology0.66370645
149MP0003828_pulmonary_edema0.66213808
150MP0004185_abnormal_adipocyte_glucose0.66163465
151MP0002932_abnormal_joint_morphology0.66141859
152MP0006035_abnormal_mitochondrial_morpho0.64335348
153MP0009672_abnormal_birth_weight0.64177499
154MP0002095_abnormal_skin_pigmentation0.63472276
155MP0006082_CNS_inflammation0.63051063

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.21927434
2Abnormal number of erythroid precursors (HP:0012131)5.08960907
3Obstructive sleep apnea (HP:0002870)4.31325796
4Broad face (HP:0000283)4.06771202
5Reticulocytopenia (HP:0001896)3.87361771
6J-shaped sella turcica (HP:0002680)3.79987924
7Birth length less than 3rd percentile (HP:0003561)3.53368134
8Cerebral aneurysm (HP:0004944)3.41560019
9Selective tooth agenesis (HP:0001592)3.32789127
10Thin bony cortex (HP:0002753)3.21054897
11Basal cell carcinoma (HP:0002671)3.17279418
12Thrombocytosis (HP:0001894)3.11096519
13Pallor (HP:0000980)3.06209366
14Ependymoma (HP:0002888)3.05508350
15Cervical subluxation (HP:0003308)3.05146621
16Entropion (HP:0000621)3.03970346
17IgM deficiency (HP:0002850)3.00936561
18Macrocytic anemia (HP:0001972)3.00517203
19Poikiloderma (HP:0001029)2.95985562
20Rough bone trabeculation (HP:0100670)2.86885953
21Abnormality of the anterior horn cell (HP:0006802)2.85165068
22Degeneration of anterior horn cells (HP:0002398)2.85165068
23Panhypogammaglobulinemia (HP:0003139)2.75929220
24Multiple enchondromatosis (HP:0005701)2.74656059
25Colon cancer (HP:0003003)2.74074086
26Stridor (HP:0010307)2.72899358
27Distal lower limb amyotrophy (HP:0008944)2.70862933
28Elevated erythrocyte sedimentation rate (HP:0003565)2.68704394
29Biconcave vertebral bodies (HP:0004586)2.67973951
30Prominent nose (HP:0000448)2.66546254
31Metaphyseal cupping (HP:0003021)2.62651152
32Premature ovarian failure (HP:0008209)2.62554048
33Recurrent viral infections (HP:0004429)2.62257596
34Breast hypoplasia (HP:0003187)2.60898243
35Eczematoid dermatitis (HP:0000976)2.60311809
36Abnormality of T cells (HP:0002843)2.59663300
37Nuclear cataract (HP:0100018)2.59108899
38Protrusio acetabuli (HP:0003179)2.59050662
39Colitis (HP:0002583)2.57364898
40Oral leukoplakia (HP:0002745)2.56162934
41Patellar aplasia (HP:0006443)2.55738535
42T lymphocytopenia (HP:0005403)2.55444351
43Dysostosis multiplex (HP:0000943)2.54742180
44Myelodysplasia (HP:0002863)2.54698287
45Hyperacusis (HP:0010780)2.53525566
46Pustule (HP:0200039)2.52875297
47Microretrognathia (HP:0000308)2.52110447
48Hemorrhage of the eye (HP:0011885)2.51157998
49Lymphangioma (HP:0100764)2.49874214
50Aplastic anemia (HP:0001915)2.45217214
51Progressive muscle weakness (HP:0003323)2.44315445
52Agnosia (HP:0010524)2.44151138
53Amaurosis fugax (HP:0100576)2.44041878
54Absent thumb (HP:0009777)2.43639022
55Chronic otitis media (HP:0000389)2.42729741
56Nasal polyposis (HP:0100582)2.41464217
57Cerebral hypomyelination (HP:0006808)2.40798158
58Increased connective tissue (HP:0009025)2.40442998
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.40149023
60Increased IgE level (HP:0003212)2.40097992
61Abnormality of the thoracic spine (HP:0100711)2.40016636
62Recurrent bronchitis (HP:0002837)2.39821130
63Lymphoma (HP:0002665)2.39351372
64Trismus (HP:0000211)2.39173412
65Aplasia/Hypoplasia of the patella (HP:0006498)2.39084752
66Medulloblastoma (HP:0002885)2.36923566
67Shallow orbits (HP:0000586)2.36214051
68Abnormality of T cell number (HP:0011839)2.33488827
69Carpal bone hypoplasia (HP:0001498)2.32992214
70Upper limb amyotrophy (HP:0009129)2.30836672
71Distal upper limb amyotrophy (HP:0007149)2.30836672
72Disproportionate tall stature (HP:0001519)2.29092230
73Squamous cell carcinoma (HP:0002860)2.28232878
74Deformed sella turcica (HP:0002681)2.27796613
75Neoplasm of the pancreas (HP:0002894)2.26940581
76Mitral regurgitation (HP:0001653)2.25626751
77Abnormality of the fingertips (HP:0001211)2.25619760
78Flat acetabular roof (HP:0003180)2.24813946
79Abnormality of T cell physiology (HP:0011840)2.24645108
80Joint stiffness (HP:0001387)2.23497897
81Abnormal number of incisors (HP:0011064)2.23433811
82Urinary glycosaminoglycan excretion (HP:0003541)2.21007981
83Mucopolysacchariduria (HP:0008155)2.21007981
84Long palpebral fissure (HP:0000637)2.18632435
85Thoracic kyphosis (HP:0002942)2.18525905
86Abnormality of chromosome stability (HP:0003220)2.17702920
87Abnormality of mucopolysaccharide metabolism (HP:0011020)2.17018519
88Abnormality of polysaccharide metabolism (HP:0011012)2.17018519
89Abnormality of glycosaminoglycan metabolism (HP:0004371)2.17018519
90B lymphocytopenia (HP:0010976)2.16702491
91Abnormality of B cell number (HP:0010975)2.16702491
92Petechiae (HP:0000967)2.16585690
93Recurrent fungal infections (HP:0002841)2.16176645
94Easy fatigability (HP:0003388)2.16155456
95Atelectasis (HP:0100750)2.15247479
96Combined immunodeficiency (HP:0005387)2.13433265
97Ulnar bowing (HP:0003031)2.12337024
98Abnormality of the heme biosynthetic pathway (HP:0010472)2.11196333
99Aneurysm (HP:0002617)2.10825759
100Abnormality of reticulocytes (HP:0004312)2.08123217
101Bone marrow hypocellularity (HP:0005528)2.07834817
102Bronchomalacia (HP:0002780)2.06899921
103Premature graying of hair (HP:0002216)2.06683680
104Abnormality of the preputium (HP:0100587)2.06424586
105Interstitial pulmonary disease (HP:0006530)2.05743441
106Emphysema (HP:0002097)2.03414885
107Atrophy/Degeneration involving motor neurons (HP:0007373)2.02270564
108Abnormality of the nasal mucosa (HP:0000433)1.99680547
109Cellular immunodeficiency (HP:0005374)1.98309888
110Distal lower limb muscle weakness (HP:0009053)1.96968634
111Difficulty climbing stairs (HP:0003551)1.96651635
112Pointed chin (HP:0000307)1.95289334
113Syringomyelia (HP:0003396)1.95286374
114Spinal cord lesions (HP:0100561)1.95286374
115Seborrheic dermatitis (HP:0001051)1.95222630
116Cleft eyelid (HP:0000625)1.93847328
117Abnormality of cells of the lymphoid lineage (HP:0012140)1.93204221
118Centrally nucleated skeletal muscle fibers (HP:0003687)1.92808523
119Overlapping toe (HP:0001845)1.92654490
120Rhabdomyosarcoma (HP:0002859)1.92092735
121IgG deficiency (HP:0004315)1.90883756
122Abnormal trabecular bone morphology (HP:0100671)1.90309305
123Gastrointestinal inflammation (HP:0004386)1.90263242
124Cafe-au-lait spot (HP:0000957)1.89658283
125Spinal canal stenosis (HP:0003416)1.88523575
126Lymphopenia (HP:0001888)1.88107753
127Personality changes (HP:0000751)1.88069846
128Abnormality of DNA repair (HP:0003254)1.87796054
129Impulsivity (HP:0100710)1.87530099
130Severe combined immunodeficiency (HP:0004430)1.87165482
131Turricephaly (HP:0000262)1.86074520
132Neuronal loss in central nervous system (HP:0002529)1.86072680
133Sparse lateral eyebrow (HP:0005338)1.84797000
134Polygenic inheritance (HP:0010982)1.84398223
135Annular pancreas (HP:0001734)1.84262420
136Tracheoesophageal fistula (HP:0002575)1.84146900
137Broad metatarsal (HP:0001783)1.83196909
138Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83088062
139Myopathic facies (HP:0002058)1.82801717
140Thin ribs (HP:0000883)1.82435380
141Proximal placement of thumb (HP:0009623)1.82216501
142Reticulocytosis (HP:0001923)1.81922425
143Secondary amenorrhea (HP:0000869)1.81248141
144Meckel diverticulum (HP:0002245)1.80712931
145Leukopenia (HP:0001882)1.80452215
146Abnormality of the umbilical cord (HP:0010881)1.80314057
147Small intestinal stenosis (HP:0012848)1.79191357
148Duodenal stenosis (HP:0100867)1.79191357
149Increased variability in muscle fiber diameter (HP:0003557)1.78206239
150Lower limb amyotrophy (HP:0007210)1.76439847
151Chromsome breakage (HP:0040012)1.76423279
152Reduced subcutaneous adipose tissue (HP:0003758)1.75016930
153Supranuclear gaze palsy (HP:0000605)1.74192012
154Preauricular skin tag (HP:0000384)1.73692100
155Gingivitis (HP:0000230)1.73096915
156Hypertriglyceridemia (HP:0002155)1.73095885
157Cellulitis (HP:0100658)1.72533546
158Segmental peripheral demyelination/remyelination (HP:0003481)1.72479814
159Abnormality of the ileum (HP:0001549)1.71790641
160Abnormal vertebral ossification (HP:0100569)1.70948248
161Aplasia/Hypoplasia of the uvula (HP:0010293)1.70599624
162Inflammation of the large intestine (HP:0002037)1.70359950
163Increased nuchal translucency (HP:0010880)1.70219661
164Skin tags (HP:0010609)1.69058498
165Hypertensive crisis (HP:0100735)1.68288545
166Deep venous thrombosis (HP:0002625)1.68179966
167Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67258752
168Dislocated radial head (HP:0003083)1.66415854
169Mildly elevated creatine phosphokinase (HP:0008180)1.66385253
170Acute lymphatic leukemia (HP:0006721)1.65864217
171Achilles tendon contracture (HP:0001771)1.65754368
172Vertebral compression fractures (HP:0002953)1.65047539
173Aortic regurgitation (HP:0001659)1.64358734
174Premature skin wrinkling (HP:0100678)1.64238967
175Gastrointestinal dysmotility (HP:0002579)1.64018091
176Blue sclerae (HP:0000592)1.63234494
177Broad palm (HP:0001169)1.63032592
178Visceral angiomatosis (HP:0100761)1.62777755
179Diaphragmatic weakness (HP:0009113)1.61456334
180Abnormality of the radial head (HP:0003995)1.61414955
181Malnutrition (HP:0004395)1.59874650
182Broad distal phalanx of finger (HP:0009836)1.58318894
183Gastrointestinal stroma tumor (HP:0100723)1.58022565
184Hypercortisolism (HP:0001578)1.57323287
185Obstructive lung disease (HP:0006536)1.56988831
186Chronic obstructive pulmonary disease (HP:0006510)1.56988831
187Systemic lupus erythematosus (HP:0002725)1.56507748
188Premature rupture of membranes (HP:0001788)1.56253068
189Flattened epiphyses (HP:0003071)1.56204018
190Abnormality of macrophages (HP:0004311)1.55523908
191Prolonged bleeding time (HP:0003010)1.55190601
192Onion bulb formation (HP:0003383)1.54708639
193Urethral obstruction (HP:0000796)1.54692038
194Long eyelashes (HP:0000527)1.54659458
195Bowel incontinence (HP:0002607)1.54531300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.71336027
2SIK13.62134516
3WEE13.37049374
4MAP4K13.24619375
5EEF2K3.09704634
6PRPF4B2.88997286
7NEK22.82804155
8NME22.77532400
9SMG12.63590998
10MAP3K102.62537868
11RIPK12.35229516
12FGFR42.33108497
13CDC72.10622181
14DYRK31.96767361
15CDK121.93728597
16TSSK61.92991161
17TRIB31.92561161
18CAMKK21.84345470
19TESK21.81666158
20STK101.76304917
21RPS6KA41.70538203
22MARK21.67174126
23EIF2AK11.66850314
24ZAP701.65036777
25TNK21.63660558
26CAMK1D1.63512271
27BRSK21.55635850
28MAP3K131.53366708
29IRAK31.50388040
30PIM21.47732380
31CDC42BPA1.47078266
32EPHB11.45640752
33SCYL21.45636004
34LRRK21.44644424
35CDK41.44605326
36RPS6KB21.44060498
37SRPK11.43349852
38GRK61.42091397
39PDGFRA1.40970761
40TTK1.40508933
41RIPK41.38937212
42SIK31.35103700
43MAP3K81.34823121
44CDK71.31746444
45MAP3K71.30798805
46PTK61.30688595
47MAP3K61.30430265
48MAPK151.28859879
49PRKD21.28765732
50MST1R1.25748395
51PLK11.25623887
52ATR1.24506010
53PASK1.21336188
54JAK31.19652258
55TAOK11.19429903
56PKN21.16446335
57ALK1.15691821
58MAP2K31.14732366
59PIM11.14643823
60NEK11.12377981
61BMX1.11853166
62TYRO31.11294314
63ACVR1B1.09628490
64SIK21.08154451
65BRSK11.07173930
66AURKB1.05664864
67TYK21.03994614
68EIF2AK31.03928369
69MAP3K141.03740453
70BTK1.03418241
71MAP3K111.02606015
72EPHA21.01836643
73CHEK11.01755412
74FLT30.98677341
75ERN10.98336416
76MAPKAPK30.97083348
77RPS6KA20.96197953
78PAK40.95991891
79MAP2K60.90904466
80PRKD30.87734645
81BLK0.87730962
82RPS6KC10.86890354
83RPS6KL10.86890354
84MARK30.86787187
85CHEK20.86373736
86HIPK20.85982970
87STK160.85854993
88MAP2K20.84744880
89MAP3K10.84204857
90CCNB10.83285896
91STK40.82696121
92CAMK1G0.82457241
93CSF1R0.81950725
94CAMKK10.79398927
95IRAK40.77061786
96DDR20.76494321
97KSR20.76313468
98TESK10.75444228
99TAOK20.74921621
100MAPK70.74096924
101MKNK10.73988735
102SYK0.73450854
103BRD40.73446742
104PDPK10.73294054
105MAPK120.72955159
106CSK0.71326395
107CDK20.71261501
108ITK0.71205549
109TLK10.70910825
110PTK20.68929535
111RPS6KA60.67363719
112LCK0.66975094
113KIT0.66495566
114PRKCI0.66272113
115AURKA0.64836828
116FGFR30.63925506
117TGFBR10.62998266
118IKBKB0.62431773
119MTOR0.61424213
120TXK0.61345557
121PLK40.60712216
122FES0.59861817
123MAPK110.59328362
124NME10.59302181
125VRK10.58561910
126RET0.58242664
127KDR0.58070725
128IKBKE0.56444981
129PAK10.55088650
130MKNK20.54835200
131TBK10.54682106
132DYRK1B0.54433040
133RPS6KA50.53199436
134MAP3K30.51366420
135IRAK20.51211672
136CSNK2A20.50651984
137BRAF0.48239790
138PDGFRB0.48012793
139ATM0.48011970
140CDK60.47867927
141HCK0.47633318
142RAF10.46212360
143NTRK10.45096403
144PAK20.43558100
145PDK10.42998024
146JAK10.42654506
147CDK90.42471266
148ICK0.40693144
149FGR0.40644294
150CDK190.40339026
151ILK0.39524809
152RPS6KA10.39373837
153CHUK0.39310728
154TEC0.39109233
155TTN0.39011042
156MAPK80.37926302
157ERBB20.37834222
158PRKD10.37146793
159MET0.35956741
160MAPK30.35437511

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.26603016
2Mismatch repair_Homo sapiens_hsa034303.66660790
3Ribosome_Homo sapiens_hsa030103.58480763
4Other glycan degradation_Homo sapiens_hsa005113.46329519
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.45226109
6Spliceosome_Homo sapiens_hsa030403.10604854
7RNA transport_Homo sapiens_hsa030132.97774950
8Base excision repair_Homo sapiens_hsa034102.96561754
9RNA polymerase_Homo sapiens_hsa030202.79345639
10Nucleotide excision repair_Homo sapiens_hsa034202.43590059
11Proteasome_Homo sapiens_hsa030502.40636459
12Homologous recombination_Homo sapiens_hsa034402.31720052
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27127518
14Cell cycle_Homo sapiens_hsa041102.25035416
15Pyrimidine metabolism_Homo sapiens_hsa002402.10746252
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.88860187
17Primary immunodeficiency_Homo sapiens_hsa053401.88221969
18One carbon pool by folate_Homo sapiens_hsa006701.80540299
19Non-homologous end-joining_Homo sapiens_hsa034501.71074423
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65133489
21Fanconi anemia pathway_Homo sapiens_hsa034601.52821941
22mRNA surveillance pathway_Homo sapiens_hsa030151.51884540
23RNA degradation_Homo sapiens_hsa030181.48584238
24Sulfur relay system_Homo sapiens_hsa041221.46407958
25p53 signaling pathway_Homo sapiens_hsa041151.44424708
26Antigen processing and presentation_Homo sapiens_hsa046121.42738406
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39667939
28Epstein-Barr virus infection_Homo sapiens_hsa051691.35726873
29Phospholipase D signaling pathway_Homo sapiens_hsa040721.31368968
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28536778
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28413866
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27566655
33Herpes simplex infection_Homo sapiens_hsa051681.26350697
34GnRH signaling pathway_Homo sapiens_hsa049121.25923923
35Choline metabolism in cancer_Homo sapiens_hsa052311.25375593
36Basal transcription factors_Homo sapiens_hsa030221.15309691
37Prion diseases_Homo sapiens_hsa050201.12663709
38Endometrial cancer_Homo sapiens_hsa052131.11315816
39Viral carcinogenesis_Homo sapiens_hsa052031.10382493
40ErbB signaling pathway_Homo sapiens_hsa040121.10210197
41Hepatitis C_Homo sapiens_hsa051601.09083697
42Insulin signaling pathway_Homo sapiens_hsa049101.08646181
43Vitamin B6 metabolism_Homo sapiens_hsa007501.06963231
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05906924
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05253719
46Pentose phosphate pathway_Homo sapiens_hsa000301.05155830
47Prolactin signaling pathway_Homo sapiens_hsa049171.04130057
48B cell receptor signaling pathway_Homo sapiens_hsa046621.03068652
49Purine metabolism_Homo sapiens_hsa002301.02787511
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02440251
51Glioma_Homo sapiens_hsa052141.01993504
52Estrogen signaling pathway_Homo sapiens_hsa049151.01610885
53Acute myeloid leukemia_Homo sapiens_hsa052211.00653935
54Renal cell carcinoma_Homo sapiens_hsa052110.99815448
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.99221293
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98761589
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98377852
58T cell receptor signaling pathway_Homo sapiens_hsa046600.96950975
59Measles_Homo sapiens_hsa051620.96609866
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.93009832
61HTLV-I infection_Homo sapiens_hsa051660.92507887
62Insulin resistance_Homo sapiens_hsa049310.90578444
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89604655
64Apoptosis_Homo sapiens_hsa042100.88358076
65Inositol phosphate metabolism_Homo sapiens_hsa005620.87853348
66Lysine degradation_Homo sapiens_hsa003100.87585937
67Chronic myeloid leukemia_Homo sapiens_hsa052200.86744613
68Shigellosis_Homo sapiens_hsa051310.86628591
69Legionellosis_Homo sapiens_hsa051340.86303970
70Focal adhesion_Homo sapiens_hsa045100.82390214
71AMPK signaling pathway_Homo sapiens_hsa041520.81957496
72Lysosome_Homo sapiens_hsa041420.80628988
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.79625964
74Oocyte meiosis_Homo sapiens_hsa041140.79250706
75Amoebiasis_Homo sapiens_hsa051460.78054753
76Systemic lupus erythematosus_Homo sapiens_hsa053220.76678500
77Leishmaniasis_Homo sapiens_hsa051400.76452114
78Hepatitis B_Homo sapiens_hsa051610.75995702
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75463889
80Pertussis_Homo sapiens_hsa051330.75148634
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74839350
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.74801509
83Thyroid cancer_Homo sapiens_hsa052160.73623296
84Endocytosis_Homo sapiens_hsa041440.73403292
85Prostate cancer_Homo sapiens_hsa052150.72490581
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72418091
87Folate biosynthesis_Homo sapiens_hsa007900.72126117
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71615788
89Staphylococcus aureus infection_Homo sapiens_hsa051500.71439181
90Hematopoietic cell lineage_Homo sapiens_hsa046400.70545031
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69017152
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68813027
93MAPK signaling pathway_Homo sapiens_hsa040100.68799525
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68611152
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.68140852
96Small cell lung cancer_Homo sapiens_hsa052220.67245391
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.65800234
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65635550
99mTOR signaling pathway_Homo sapiens_hsa041500.64974016
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.63949458
101Proteoglycans in cancer_Homo sapiens_hsa052050.63746682
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63122426
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63098543
104Galactose metabolism_Homo sapiens_hsa000520.62550514
105Biosynthesis of amino acids_Homo sapiens_hsa012300.62223842
106Salmonella infection_Homo sapiens_hsa051320.61657734
107Rap1 signaling pathway_Homo sapiens_hsa040150.61325145
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60633540
109Colorectal cancer_Homo sapiens_hsa052100.59044175
110Influenza A_Homo sapiens_hsa051640.58913706
111Melanogenesis_Homo sapiens_hsa049160.58883709
112Regulation of autophagy_Homo sapiens_hsa041400.57908942
113Malaria_Homo sapiens_hsa051440.56056323
114Long-term potentiation_Homo sapiens_hsa047200.56001680
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.53718313
116Osteoclast differentiation_Homo sapiens_hsa043800.52918198
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.49999267
118ABC transporters_Homo sapiens_hsa020100.49114121
119Fructose and mannose metabolism_Homo sapiens_hsa000510.48891719
120MicroRNAs in cancer_Homo sapiens_hsa052060.48771171
121HIF-1 signaling pathway_Homo sapiens_hsa040660.47104657
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46004606
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44995764
124VEGF signaling pathway_Homo sapiens_hsa043700.44512574
125Non-small cell lung cancer_Homo sapiens_hsa052230.44324710
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43910590
127Notch signaling pathway_Homo sapiens_hsa043300.42459214
128Viral myocarditis_Homo sapiens_hsa054160.42303099
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42208504
130Toxoplasmosis_Homo sapiens_hsa051450.41589138
131N-Glycan biosynthesis_Homo sapiens_hsa005100.40809791
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.38167792
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.34618200
134Allograft rejection_Homo sapiens_hsa053300.32548906
135Alcoholism_Homo sapiens_hsa050340.31067092
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.30958212
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30654068
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30074472
139Tuberculosis_Homo sapiens_hsa051520.29695365
140Bladder cancer_Homo sapiens_hsa052190.28162204
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28016282
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26335555
143Pancreatic cancer_Homo sapiens_hsa052120.26120193
144Selenocompound metabolism_Homo sapiens_hsa004500.26050336
145Chemokine signaling pathway_Homo sapiens_hsa040620.25358182
146Platelet activation_Homo sapiens_hsa046110.25185438
147FoxO signaling pathway_Homo sapiens_hsa040680.25046571
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23455047
149TNF signaling pathway_Homo sapiens_hsa046680.23063282

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