TAF1D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TAF1D is a member of the SL1 complex, which includes TBP (MIM 600075) and TAF1A (MIM 604903), TAF1B (MIM 604904), and TAF1C (MIM 604905), and plays a role in RNA polymerase I transcription (Wang et al., 2004 [PubMed 15520167]; Gorski et al., 2007 [PubMed 17318177]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)8.75316587
2nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)6.04232898
3prenylation (GO:0097354)5.89427795
4protein prenylation (GO:0018342)5.89427795
5molting cycle (GO:0042303)5.65351774
6hair cycle (GO:0042633)5.65351774
7maturation of SSU-rRNA (GO:0030490)5.54974318
8ribosomal small subunit biogenesis (GO:0042274)5.50999787
9ribosomal small subunit assembly (GO:0000028)5.50774213
10viral mRNA export from host cell nucleus (GO:0046784)5.39578989
11viral transcription (GO:0019083)5.21983651
12regulation of DNA damage checkpoint (GO:2000001)5.15856873
13translational termination (GO:0006415)5.12283881
14positive regulation of p38MAPK cascade (GO:1900745)4.82849889
15ribosomal large subunit biogenesis (GO:0042273)4.71916532
16negative regulation of DNA repair (GO:0045738)4.68878710
17regulation of somitogenesis (GO:0014807)4.64521755
18replicative senescence (GO:0090399)4.63181545
19regulation of cell proliferation involved in kidney development (GO:1901722)4.57176633
20positive regulation of cellular amide metabolic process (GO:0034250)4.39669269
21translational elongation (GO:0006414)4.32234119
22kinetochore organization (GO:0051383)4.31086450
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.30701684
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.28735587
25cotranslational protein targeting to membrane (GO:0006613)4.25355442
26mitotic metaphase plate congression (GO:0007080)4.24729180
27CENP-A containing nucleosome assembly (GO:0034080)4.24159203
28ribonucleoprotein complex biogenesis (GO:0022613)4.23735796
29chromatin remodeling at centromere (GO:0031055)4.23194801
30protein targeting to ER (GO:0045047)4.20971909
31translational initiation (GO:0006413)4.19207298
32cellular protein complex disassembly (GO:0043624)4.04117701
33establishment of protein localization to endoplasmic reticulum (GO:0072599)4.01978682
34monoubiquitinated protein deubiquitination (GO:0035520)3.98651466
35antimicrobial humoral response (GO:0019730)3.97892617
36viral life cycle (GO:0019058)3.94128938
37protein localization to endoplasmic reticulum (GO:0070972)3.93803284
38DNA replication checkpoint (GO:0000076)3.90715974
39pyrimidine dimer repair (GO:0006290)3.90591732
40nuclear pore organization (GO:0006999)3.88940216
41DNA replication initiation (GO:0006270)3.87330902
42regulation of centrosome cycle (GO:0046605)3.85877462
43kinetochore assembly (GO:0051382)3.85819976
44nuclear pore complex assembly (GO:0051292)3.85559866
45metaphase plate congression (GO:0051310)3.84927236
46establishment of skin barrier (GO:0061436)3.82181401
47rRNA processing (GO:0006364)3.80784492
48antibacterial humoral response (GO:0019731)3.78824907
49DNA replication-independent nucleosome assembly (GO:0006336)3.76573499
50DNA replication-independent nucleosome organization (GO:0034724)3.76573499
51telomere maintenance via semi-conservative replication (GO:0032201)3.72939379
52sulfation (GO:0051923)3.72734786
53positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.72189318
54regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.72189318
55regulation of centriole replication (GO:0046599)3.72019397
56protein localization to kinetochore (GO:0034501)3.71264162
57rRNA metabolic process (GO:0016072)3.69172112
58DNA strand elongation involved in DNA replication (GO:0006271)3.68839699
59meiotic chromosome segregation (GO:0045132)3.68035377
60formation of translation preinitiation complex (GO:0001731)3.62971850
61positive regulation of interleukin-8 secretion (GO:2000484)3.62276117
62regulation of DNA endoreduplication (GO:0032875)3.60847278
63nucleobase biosynthetic process (GO:0046112)3.60245955
64positive regulation of glomerulus development (GO:0090193)3.60030631
65telomere maintenance via recombination (GO:0000722)3.59974827
66ribosome biogenesis (GO:0042254)3.59347805
67protein K11-linked deubiquitination (GO:0035871)3.58640818
68purine nucleobase biosynthetic process (GO:0009113)3.57179759
69DNA strand elongation (GO:0022616)3.56116296
70protein complex disassembly (GO:0043241)3.55528554
71positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.53880892
72histone exchange (GO:0043486)3.49982756
73mitotic recombination (GO:0006312)3.47811446
74nuclear-transcribed mRNA catabolic process (GO:0000956)3.46430806
75regulation of nuclear cell cycle DNA replication (GO:0033262)3.46141174
76ribosome assembly (GO:0042255)3.38719365
77macromolecular complex disassembly (GO:0032984)3.37743768
78transcription elongation from RNA polymerase III promoter (GO:0006385)3.37642838
79termination of RNA polymerase III transcription (GO:0006386)3.37642838
80attachment of spindle microtubules to kinetochore (GO:0008608)3.37154022
81* transcription elongation from RNA polymerase I promoter (GO:0006362)3.36171388
82rRNA modification (GO:0000154)3.36021268
83positive regulation of T-helper 1 type immune response (GO:0002827)3.31980932
84mRNA catabolic process (GO:0006402)3.31114683
85spliceosomal snRNP assembly (GO:0000387)3.30639186
86regulation of histone H3-K9 methylation (GO:0051570)3.29652523
87* termination of RNA polymerase I transcription (GO:0006363)3.29442615
88nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)3.29103363
89DNA unwinding involved in DNA replication (GO:0006268)3.28400015
90establishment of integrated proviral latency (GO:0075713)3.27942043
91translation (GO:0006412)3.26087978
92DNA replication-dependent nucleosome assembly (GO:0006335)3.25351696
93DNA replication-dependent nucleosome organization (GO:0034723)3.25351696
94telomere maintenance via telomere lengthening (GO:0010833)3.23482054
95cellular component biogenesis (GO:0044085)3.20636191
96establishment of chromosome localization (GO:0051303)3.20587923
97RNA catabolic process (GO:0006401)3.20489692
98positive regulation of humoral immune response (GO:0002922)3.20238406
99snRNA transcription (GO:0009301)3.19278428
100regulation of glomerulus development (GO:0090192)3.17724515
101response to UV-C (GO:0010225)3.16950993
102transcription-coupled nucleotide-excision repair (GO:0006283)3.16403692
103negative regulation of DNA-dependent DNA replication (GO:2000104)3.16060464
104protein localization to chromosome, centromeric region (GO:0071459)3.15575032
105spliceosomal complex assembly (GO:0000245)3.15358437
106regulation of p38MAPK cascade (GO:1900744)3.14438103
107regulation of transforming growth factor beta1 production (GO:0032908)3.13742134
108maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12981510
109protein K6-linked ubiquitination (GO:0085020)3.12793118
110nucleotide-excision repair, DNA gap filling (GO:0006297)3.10350226
111pseudouridine synthesis (GO:0001522)3.10326225
112maturation of 5.8S rRNA (GO:0000460)3.10111697
1137-methylguanosine mRNA capping (GO:0006370)3.07634227
114innate immune response in mucosa (GO:0002227)3.07100349
115regulation of spindle organization (GO:0090224)3.06753893
1167-methylguanosine RNA capping (GO:0009452)3.06347899
117RNA capping (GO:0036260)3.06347899
118mitotic nuclear envelope disassembly (GO:0007077)3.06239338
119proteasome assembly (GO:0043248)3.04265602
120* transcription from RNA polymerase I promoter (GO:0006360)3.03377227
121regulation of centrosome duplication (GO:0010824)3.02675160
122pore complex assembly (GO:0046931)3.02538170
123protein K48-linked deubiquitination (GO:0071108)3.01293903
124positive regulation of mitotic sister chromatid separation (GO:1901970)3.00579692
125positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00579692
126positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00579692
127negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.99937824
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98618592
129anterior/posterior axis specification, embryo (GO:0008595)2.98422549
130mitotic chromosome condensation (GO:0007076)2.97785308
131dorsal/ventral axis specification (GO:0009950)2.97732605
132spindle checkpoint (GO:0031577)2.97272365
133cellular protein complex localization (GO:0034629)2.94325231
134regulation of water loss via skin (GO:0033561)2.93580969
135* DNA-templated transcription, termination (GO:0006353)2.92869041
136positive regulation of DNA-templated transcription, elongation (GO:0032786)2.92278880
137microtubule depolymerization (GO:0007019)2.91607311
138exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90069724
139trophoblast giant cell differentiation (GO:0060707)2.89622523
140keratinocyte differentiation (GO:0030216)2.88378363
141T cell mediated immunity (GO:0002456)2.88203979
142mitotic sister chromatid segregation (GO:0000070)2.86588685
143regulation of helicase activity (GO:0051095)2.83893323
144somatic hypermutation of immunoglobulin genes (GO:0016446)2.83353619
145somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83353619
146nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.82796978
147rRNA methylation (GO:0031167)2.82657034
148histone mRNA metabolic process (GO:0008334)2.82267094
149* transcription initiation from RNA polymerase I promoter (GO:0006361)2.82168181
150protein K63-linked deubiquitination (GO:0070536)2.82089104
151ncRNA processing (GO:0034470)2.81872679
152IMP biosynthetic process (GO:0006188)2.80485060
153termination of RNA polymerase II transcription (GO:0006369)2.79231619
154RNA splicing, via transesterification reactions (GO:0000375)2.79129449
155membrane disassembly (GO:0030397)2.78541356
156nuclear envelope disassembly (GO:0051081)2.78541356
157DNA integration (GO:0015074)2.78061144
158histone-serine phosphorylation (GO:0035404)2.75763382
159regulation of cell cycle checkpoint (GO:1901976)2.72142985
160positive regulation of RNA splicing (GO:0033120)2.68992525
161epidermal cell differentiation (GO:0009913)2.67926696
162DNA synthesis involved in DNA repair (GO:0000731)2.66867644
163negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.65099214
164epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.63562761
165replication fork processing (GO:0031297)2.61736409
166regulation of histone H3-K27 methylation (GO:0061085)2.61178817
167desmosome organization (GO:0002934)2.60449398
168mucosal immune response (GO:0002385)2.56836958
169regulation of RNA export from nucleus (GO:0046831)2.54156339
170regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.53699261
171hematopoietic stem cell proliferation (GO:0071425)2.53489605
172embryonic process involved in female pregnancy (GO:0060136)2.52743601
173keratinocyte development (GO:0003334)2.52387845
174nucleosome assembly (GO:0006334)2.51974652
175post-anal tail morphogenesis (GO:0036342)2.51196516
176regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.50279646
177mitotic sister chromatid cohesion (GO:0007064)2.47824662
178telomere maintenance via telomerase (GO:0007004)2.47239634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.23216698
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.25560487
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.49571842
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.15201488
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.85253858
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.71059388
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.38429742
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.33899941
9STAT6_21828071_ChIP-Seq_BEAS2B_Human3.26161363
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.23614545
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19253743
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.07695532
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.94955472
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94437711
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.89614530
16GATA1_22025678_ChIP-Seq_K562_Human2.81450513
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.77289866
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73801654
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.72579329
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70083101
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66866688
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59124028
23VDR_23849224_ChIP-Seq_CD4+_Human2.54232668
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37517719
25ELK1_19687146_ChIP-ChIP_HELA_Human2.37339162
26* XRN2_22483619_ChIP-Seq_HELA_Human2.30034729
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.24072435
28EGR1_23403033_ChIP-Seq_LIVER_Mouse2.22002737
29* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20926783
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20859841
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.09630148
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.08804326
33FOXP3_21729870_ChIP-Seq_TREG_Human2.08458992
34TTF2_22483619_ChIP-Seq_HELA_Human2.06431766
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.04180888
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03040947
37ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02054786
38AR_21909140_ChIP-Seq_LNCAP_Human1.97669871
39DCP1A_22483619_ChIP-Seq_HELA_Human1.95884214
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94749778
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.94674524
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92180586
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83419268
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79326076
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78423739
46TP53_16413492_ChIP-PET_HCT116_Human1.77864931
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77744623
48* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76044889
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72650195
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70460029
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70082422
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.70031159
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.67765144
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.67765144
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67595279
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.66134218
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65965887
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65672602
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60309148
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59472479
61GABP_19822575_ChIP-Seq_HepG2_Human1.57644179
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56537622
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54752252
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46948412
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.46184188
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43897337
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.43528860
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43447223
69PKCTHETA_26484144_Chip-Seq_BREAST_Human1.42423339
70FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.41913866
71* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40496422
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.33520658
73MYC_18940864_ChIP-ChIP_HL60_Human1.32197258
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31480133
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30491329
76* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25648522
77* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25329288
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24489347
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23659062
80CIITA_25753668_ChIP-Seq_RAJI_Human1.22945704
81KDM5A_27292631_Chip-Seq_BREAST_Human1.22126452
82ELK1_22589737_ChIP-Seq_MCF10A_Human1.21559674
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18202385
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17091107
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15241425
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14941190
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13807773
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12902636
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10132243
90TP63_17297297_ChIP-ChIP_HaCaT_Human1.10020050
91IRF1_19129219_ChIP-ChIP_H3396_Human1.09898366
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.07723963
93FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07683251
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07523236
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07523236
96KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07523236
97SOX2_16153702_ChIP-ChIP_HESCs_Human1.06734893
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04221714
99UBF1/2_26484160_Chip-Seq_HMECs_Human1.03557455
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01852611
101SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01335603
102CHD1_26751641_Chip-Seq_LNCaP_Human0.99712787
103LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99364977
104CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98513790
105SMAD_19615063_ChIP-ChIP_OVARY_Human0.96400905
106POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94643016
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94114419
108AR_21572438_ChIP-Seq_LNCaP_Human0.93766173
109NANOG_16153702_ChIP-ChIP_HESCs_Human0.92246673
110HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91949226
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91494305
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91411169
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91265948
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90722769
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90105357
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89154444
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87493679
118* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86678467
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.86607109
120TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86585452
121STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86548435
122POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85806749
123VDR_21846776_ChIP-Seq_THP-1_Human0.85611796
124SPI1_23547873_ChIP-Seq_NB4_Human0.83480293
125NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83126746
126FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82557862
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82006533
128ELF5_23300383_ChIP-Seq_T47D_Human0.81609607
129TFEB_21752829_ChIP-Seq_HELA_Human0.81303676
130GATA6_25053715_ChIP-Seq_YYC3_Human0.80907358
131KLF4_18555785_ChIP-Seq_MESCs_Mouse0.80558887
132ETS1_22383799_ChIP-Seq_G1ME_Mouse0.80461483
133* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80000082
134IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79621332
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78547073
136SOX17_20123909_ChIP-Seq_XEN_Mouse0.77383316
137GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77110980
138* EWS_26573619_Chip-Seq_HEK293_Human0.76933014
139CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76816716
140FUS_26573619_Chip-Seq_HEK293_Human0.75996401
141CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75708955
142ATF3_27146783_Chip-Seq_COLON_Human0.75491098
143FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.75447350
144MYB_26560356_Chip-Seq_TH1_Human0.75271277
145NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.74754247
146VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74143041

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.16250261
2MP0008057_abnormal_DNA_replication4.34898829
3MP0010094_abnormal_chromosome_stability4.33898028
4MP0004957_abnormal_blastocyst_morpholog4.15098446
5MP0003111_abnormal_nucleus_morphology3.89767323
6MP0002796_impaired_skin_barrier3.87475776
7MP0003077_abnormal_cell_cycle3.78609018
8MP0010234_abnormal_vibrissa_follicle3.70528679
9MP0008058_abnormal_DNA_repair3.57648779
10MP0000569_abnormal_digit_pigmentation3.09662071
11MP0009379_abnormal_foot_pigmentation2.73785067
12MP0008007_abnormal_cellular_replicative2.73320205
13MP0008932_abnormal_embryonic_tissue2.60209493
14MP0005083_abnormal_biliary_tract2.53460791
15MP0005275_abnormal_skin_tensile2.52041853
16MP0010678_abnormal_skin_adnexa2.46761678
17MP0005501_abnormal_skin_physiology2.40179510
18MP0003786_premature_aging2.36104522
19MP0003123_paternal_imprinting2.29074506
20MP0002396_abnormal_hematopoietic_system2.26303267
21MP0005076_abnormal_cell_differentiation2.23756496
22MP0008877_abnormal_DNA_methylation2.23017939
23MP0003950_abnormal_plasma_membrane2.22684496
24MP0006292_abnormal_olfactory_placode2.21846748
25MP0004264_abnormal_extraembryonic_tissu2.16642114
26MP0000579_abnormal_nail_morphology1.97738664
27MP0000350_abnormal_cell_proliferation1.93550901
28MP0004185_abnormal_adipocyte_glucose1.85166901
29MP0001730_embryonic_growth_arrest1.84327059
30MP0003136_yellow_coat_color1.77306449
31MP0003718_maternal_effect1.76520570
32MP0003941_abnormal_skin_development1.70534517
33MP0001216_abnormal_epidermal_layer1.69928300
34MP0003221_abnormal_cardiomyocyte_apopto1.69303003
35MP0002060_abnormal_skin_morphology1.64298368
36MP0005171_absent_coat_pigmentation1.58957918
37MP0003183_abnormal_peptide_metabolism1.57794684
38MP0003121_genomic_imprinting1.55812633
39MP0003453_abnormal_keratinocyte_physiol1.50895222
40MP0010771_integument_phenotype1.48217730
41MP0003656_abnormal_erythrocyte_physiolo1.46484553
42MP0005380_embryogenesis_phenotype1.45130673
43MP0001672_abnormal_embryogenesis/_devel1.45130673
44MP0000490_abnormal_crypts_of1.44478224
45MP0003315_abnormal_perineum_morphology1.42690500
46MP0010307_abnormal_tumor_latency1.40540023
47MP0001697_abnormal_embryo_size1.39232774
48MP0003567_abnormal_fetal_cardiomyocyte1.36219316
49MP0000566_synostosis1.34718817
50MP0002210_abnormal_sex_determination1.34438965
51MP0004808_abnormal_hematopoietic_stem1.32789193
52MP0002085_abnormal_embryonic_tissue1.31093341
53MP0005220_abnormal_exocrine_pancreas1.25246263
54MP0001293_anophthalmia1.24810208
55MP0000313_abnormal_cell_death1.24158882
56MP0002084_abnormal_developmental_patter1.23888337
57MP0002938_white_spotting1.23736557
58MP0003763_abnormal_thymus_physiology1.22639428
59MP0003890_abnormal_embryonic-extraembry1.22291272
60MP0002080_prenatal_lethality1.19981048
61MP0003984_embryonic_growth_retardation1.19914995
62MP0001188_hyperpigmentation1.19344450
63MP0002088_abnormal_embryonic_growth/wei1.17388337
64MP0010352_gastrointestinal_tract_polyps1.16084289
65MP0008995_early_reproductive_senescence1.15694142
66MP0003937_abnormal_limbs/digits/tail_de1.14453115
67MP0001145_abnormal_male_reproductive1.11755747
68MP0009333_abnormal_splenocyte_physiolog1.10760446
69MP0002098_abnormal_vibrissa_morphology1.09454328
70MP0002019_abnormal_tumor_incidence1.09404344
71MP0002086_abnormal_extraembryonic_tissu1.08447039
72MP0002095_abnormal_skin_pigmentation1.07923731
73MP0000762_abnormal_tongue_morphology1.07437173
74MP0002166_altered_tumor_susceptibility1.06913091
75MP0004197_abnormal_fetal_growth/weight/1.06623077
76MP0002277_abnormal_respiratory_mucosa1.04943136
77MP0000703_abnormal_thymus_morphology1.04288823
78MP0000367_abnormal_coat/_hair1.03549804
79MP0001929_abnormal_gametogenesis1.03249237
80MP0002102_abnormal_ear_morphology1.01872990
81MP0000653_abnormal_sex_gland1.01369929
82MP0004381_abnormal_hair_follicle0.99270350
83MP0001191_abnormal_skin_condition0.98722767
84MP0002138_abnormal_hepatobiliary_system0.97080487
85MP0000377_abnormal_hair_follicle0.97041710
86MP0004272_abnormal_basement_membrane0.96985482
87MP0000427_abnormal_hair_cycle0.96803883
88MP0001286_abnormal_eye_development0.96555803
89MP0000003_abnormal_adipose_tissue0.95615021
90MP0005397_hematopoietic_system_phenotyp0.91715490
91MP0001545_abnormal_hematopoietic_system0.91715490
92MP0002132_abnormal_respiratory_system0.91669418
93MP0001119_abnormal_female_reproductive0.91560543
94MP0002398_abnormal_bone_marrow0.91459199
95MP0000371_diluted_coat_color0.90855288
96MP0004947_skin_inflammation0.90717133
97MP0005174_abnormal_tail_pigmentation0.90138959
98MP0005075_abnormal_melanosome_morpholog0.87259727
99MP0002722_abnormal_immune_system0.86313676
100MP0004133_heterotaxia0.85160962
101MP0010030_abnormal_orbit_morphology0.84299133
102MP0000689_abnormal_spleen_morphology0.82520574
103MP0005389_reproductive_system_phenotype0.81429995
104MP0003938_abnormal_ear_development0.81157464
105MP0000358_abnormal_cell_content/0.80647669
106MP0009931_abnormal_skin_appearance0.80645228
107MP0001784_abnormal_fluid_regulation0.79999091
108MP0000428_abnormal_craniofacial_morphol0.77601946
109MP0001502_abnormal_circadian_rhythm0.73647212
110MP0001177_atelectasis0.73370968
111MP0002111_abnormal_tail_morphology0.73275973
112MP0000383_abnormal_hair_follicle0.73103014
113MP0000372_irregular_coat_pigmentation0.72890305
114MP0002089_abnormal_postnatal_growth/wei0.72184120
115MP0000432_abnormal_head_morphology0.71781216
116MP0003959_abnormal_lean_body0.71721692
117MP0001853_heart_inflammation0.71478475
118MP0009697_abnormal_copulation0.70806002
119MP0002160_abnormal_reproductive_system0.70781324
120MP0004134_abnormal_chest_morphology0.70463326
121MP0003787_abnormal_imprinting0.70199006
122MP0005408_hypopigmentation0.69309609
123MP0005367_renal/urinary_system_phenotyp0.68584504
124MP0000516_abnormal_urinary_system0.68584504
125MP0008770_decreased_survivor_rate0.67573813
126MP0000733_abnormal_muscle_development0.67407848
127MP0002429_abnormal_blood_cell0.67217304
128MP0005375_adipose_tissue_phenotype0.66206877
129MP0001986_abnormal_taste_sensitivity0.65241241
130MP0002009_preneoplasia0.65106668
131MP0003705_abnormal_hypodermis_morpholog0.64551255
132MP0003936_abnormal_reproductive_system0.63777811
133MP0009250_abnormal_appendicular_skeleto0.63393912
134MP0001919_abnormal_reproductive_system0.62764016
135MP0001243_abnormal_dermal_layer0.62714986
136MP0008789_abnormal_olfactory_epithelium0.62073943
137MP0005379_endocrine/exocrine_gland_phen0.61707306
138MP0002163_abnormal_gland_morphology0.61232951
139MP0000716_abnormal_immune_system0.60746866
140MP0002751_abnormal_autonomic_nervous0.60597175
141MP0002092_abnormal_eye_morphology0.59661855
142MP0005671_abnormal_response_to0.58904640
143MP0000537_abnormal_urethra_morphology0.58881680
144MP0003755_abnormal_palate_morphology0.57734803
145MP0005384_cellular_phenotype0.56940448
146MP0002006_tumorigenesis0.56252847
147MP0005409_darkened_coat_color0.55997812
148MP0001186_pigmentation_phenotype0.55677306
149MP0003119_abnormal_digestive_system0.54077101

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)5.68891944
2Reticulocytopenia (HP:0001896)5.19470616
3Abnormality of cells of the erythroid lineage (HP:0012130)4.79656570
4Birth length less than 3rd percentile (HP:0003561)4.62222557
5Abnormal number of erythroid precursors (HP:0012131)4.28519924
6Chromsome breakage (HP:0040012)4.23440150
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.94751290
8Macrocytic anemia (HP:0001972)3.62222714
9Pallor (HP:0000980)3.58284612
10Breast hypoplasia (HP:0003187)3.25514764
11Abnormality of the preputium (HP:0100587)3.24458024
12Abnormality of the parietal bone (HP:0002696)3.23208161
13Abnormality of chromosome stability (HP:0003220)3.21475034
14Anomalous pulmonary venous return (HP:0010772)3.18858846
15Colon cancer (HP:0003003)3.18342156
16Aplastic anemia (HP:0001915)3.12712699
17Deformed sella turcica (HP:0002681)3.09361222
18Lip pit (HP:0100267)3.08683482
19Oral leukoplakia (HP:0002745)3.07066471
20Meckel diverticulum (HP:0002245)3.04110811
21Slow saccadic eye movements (HP:0000514)2.99682129
22Diastasis recti (HP:0001540)2.99597777
23Patellar aplasia (HP:0006443)2.98724883
24Ectropion (HP:0000656)2.96994252
25Absent thumb (HP:0009777)2.96003642
26Abnormality of the nasal septum (HP:0000419)2.92411940
27Short 4th metacarpal (HP:0010044)2.91457460
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.91457460
29Abnormality of the ileum (HP:0001549)2.90941229
30Supernumerary spleens (HP:0009799)2.89119641
31Aplasia/Hypoplasia of the patella (HP:0006498)2.77509192
32Abnormality of the pulmonary veins (HP:0011718)2.77163338
33Absent radius (HP:0003974)2.76819925
34Myelodysplasia (HP:0002863)2.73473086
35Abnormality of the labia minora (HP:0012880)2.72656207
3611 pairs of ribs (HP:0000878)2.69736132
37Carpal bone hypoplasia (HP:0001498)2.69580613
38Rough bone trabeculation (HP:0100670)2.68846436
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.68206154
40Milia (HP:0001056)2.67370757
41Poikiloderma (HP:0001029)2.62396940
42Hypoplastic pelvis (HP:0008839)2.62025668
43Increased hepatocellular lipid droplets (HP:0006565)2.59389815
44Aplasia involving forearm bones (HP:0009822)2.57602192
45Absent forearm bone (HP:0003953)2.57602192
46Impulsivity (HP:0100710)2.56983887
47Parakeratosis (HP:0001036)2.54468050
48Short phalanx of the thumb (HP:0009660)2.50680112
49Premature graying of hair (HP:0002216)2.49724905
50Abnormality of the sella turcica (HP:0002679)2.49525319
51Sparse lateral eyebrow (HP:0005338)2.47186710
52Basal cell carcinoma (HP:0002671)2.46833271
53Vertebral fusion (HP:0002948)2.45110021
54Abnormal lung lobation (HP:0002101)2.44310677
55Volvulus (HP:0002580)2.41558839
56Neoplasm of the heart (HP:0100544)2.41027891
57Triphalangeal thumb (HP:0001199)2.40812993
58Skin pits (HP:0100276)2.40444478
59Wide intermamillary distance (HP:0006610)2.40331693
60Medulloblastoma (HP:0002885)2.38543490
61Abnormality of the pons (HP:0007361)2.36871049
62Vertebral arch anomaly (HP:0008438)2.36698117
63Aplasia/Hypoplasia of the sacrum (HP:0008517)2.36214408
64Duplicated collecting system (HP:0000081)2.36131012
65Impaired smooth pursuit (HP:0007772)2.33969902
66Small intestinal stenosis (HP:0012848)2.33312790
67Duodenal stenosis (HP:0100867)2.33312790
68Broad ribs (HP:0000885)2.33110234
69Congenital ichthyosiform erythroderma (HP:0007431)2.32585429
70Hamartoma (HP:0010566)2.30930876
71Stenosis of the external auditory canal (HP:0000402)2.26595072
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.25665201
73Bone marrow hypocellularity (HP:0005528)2.25588952
74Horseshoe kidney (HP:0000085)2.25204245
75Selective tooth agenesis (HP:0001592)2.23485244
76Abnormal auditory evoked potentials (HP:0006958)2.19047223
77Palmoplantar hyperkeratosis (HP:0000972)2.15080713
78Abnormal number of incisors (HP:0011064)2.14837682
79Ectopic kidney (HP:0000086)2.14244023
80Asplenia (HP:0001746)2.14117518
81Erythroderma (HP:0001019)2.14003799
82Abnormality of the renal collecting system (HP:0004742)2.13606753
83Abnormal trabecular bone morphology (HP:0100671)2.12992933
84Cellular immunodeficiency (HP:0005374)2.12464827
85Palmar hyperkeratosis (HP:0010765)2.12254511
86Neoplasm of the oral cavity (HP:0100649)2.12097249
87Hypoplasia of the pons (HP:0012110)2.11173434
88Squamous cell carcinoma (HP:0002860)2.10897715
89Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.09838063
90Thoracolumbar scoliosis (HP:0002944)2.09464605
91Nephroblastoma (Wilms tumor) (HP:0002667)2.08963899
92Entropion (HP:0000621)2.08879652
93Increased IgE level (HP:0003212)2.08524992
94Cleft eyelid (HP:0000625)2.08232751
95Aortic regurgitation (HP:0001659)2.08032401
96Short thumb (HP:0009778)2.07403374
97Short chin (HP:0000331)2.07240483
98Neoplasm of striated muscle (HP:0009728)2.06912673
99Thrombocytosis (HP:0001894)2.06271530
100Exertional dyspnea (HP:0002875)2.05755718
101Sloping forehead (HP:0000340)2.04549101
102Agnosia (HP:0010524)2.01444873
103Lipid accumulation in hepatocytes (HP:0006561)2.01037766
104Genetic anticipation (HP:0003743)2.00178155
105Tracheoesophageal fistula (HP:0002575)1.99635726
106Cerebral hypomyelination (HP:0006808)1.99418034
107Abnormality of the 4th metacarpal (HP:0010012)1.98678514
108Glossoptosis (HP:0000162)1.98010951
109Down-sloping shoulders (HP:0200021)1.97604847
110Dry hair (HP:0011359)1.97144443
111Embryonal renal neoplasm (HP:0011794)1.97099455
112Abnormality of the duodenum (HP:0002246)1.95786322
113Congenital, generalized hypertrichosis (HP:0004540)1.95601647
114Neoplasm of the pancreas (HP:0002894)1.93552191
115Abnormality of DNA repair (HP:0003254)1.93154721
116Hypoplasia of the radius (HP:0002984)1.92912895
117Hemivertebrae (HP:0002937)1.92720781
118Abnormality of the distal phalanx of the thumb (HP:0009617)1.92459016
119Clubbing of toes (HP:0100760)1.91711126
120Abnormality of the labia majora (HP:0012881)1.91587546
121Abnormality of ocular smooth pursuit (HP:0000617)1.91228879
122Ureteral duplication (HP:0000073)1.90926947
123Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90713110
124Lymphoma (HP:0002665)1.90013455
125Aplasia/Hypoplasia of the spleen (HP:0010451)1.89689171
126Atresia of the external auditory canal (HP:0000413)1.89192449
127Abnormality of the epiphyses of the hand (HP:0005924)1.88929258
128Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.88127273
129Respiratory difficulties (HP:0002880)1.85896763
130Aplasia/Hypoplasia of the sternum (HP:0006714)1.85757767
131Facial hemangioma (HP:0000329)1.85713660
132Erythema (HP:0010783)1.85664039
133Small hand (HP:0200055)1.85002747
134Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.84480351
135Ependymoma (HP:0002888)1.82825645
136Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81962547
137Abnormal spermatogenesis (HP:0008669)1.80204712
138Fair hair (HP:0002286)1.79584725
139Plantar hyperkeratosis (HP:0007556)1.79390017
140Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78817759
141Spinal cord lesions (HP:0100561)1.78585473
142Syringomyelia (HP:0003396)1.78585473
143Corneal erosion (HP:0200020)1.78408653
144Increased number of teeth (HP:0011069)1.78087579
145Flat acetabular roof (HP:0003180)1.77851508
146Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.77189672
147Acute myeloid leukemia (HP:0004808)1.76389091
148Facial cleft (HP:0002006)1.75876038
149Abnormality of the odontoid process (HP:0003310)1.75257641
150Thick nail (HP:0001805)1.74930099
151Abnormality of the carotid arteries (HP:0005344)1.74867320
152Pancytopenia (HP:0001876)1.74830506
153Trismus (HP:0000211)1.74271729
154Woolly hair (HP:0002224)1.73846696
155Amaurosis fugax (HP:0100576)1.73133017
156Acute necrotizing encephalopathy (HP:0006965)1.72216451
157Secondary amenorrhea (HP:0000869)1.71664405
158Rhabdomyosarcoma (HP:0002859)1.71258385
159Acute lymphatic leukemia (HP:0006721)1.70299554
160Abnormality of the anterior horn cell (HP:0006802)1.69286535
161Degeneration of anterior horn cells (HP:0002398)1.69286535
162Depressed nasal ridge (HP:0000457)1.69032696
163Renal Fanconi syndrome (HP:0001994)1.68759357
164Abnormal hemoglobin (HP:0011902)1.67064347
165Proximal placement of thumb (HP:0009623)1.66978354
1663-Methylglutaconic aciduria (HP:0003535)1.66702193
167Aplasia/Hypoplasia of the earlobes (HP:0009906)1.66132134
168Prominent nose (HP:0000448)1.65969263
169Prostate neoplasm (HP:0100787)1.65284005
170Sparse eyelashes (HP:0000653)1.65187289

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.20652984
2WEE14.05797993
3SRPK13.88139969
4CDC73.83886292
5BUB13.51325486
6NME22.91521006
7VRK12.78781883
8EIF2AK12.62249078
9STK162.51784014
10PLK42.50025218
11MKNK12.45085852
12PDK22.34990229
13ACVR1B2.28124203
14BRSK22.24966495
15TLK12.20168422
16TTK2.20060370
17NEK22.15820144
18MKNK22.11314859
19ZAK2.08518760
20PLK11.96053352
21PLK31.88174895
22AURKB1.87572688
23TSSK61.83846933
24DYRK31.83239960
25EIF2AK31.78546221
26CDK71.69617685
27ATR1.63365751
28RPS6KB21.62012859
29CHEK21.54603427
30PBK1.53561940
31MAP3K41.51365048
32NEK91.48332458
33MST41.43622267
34FRK1.43088904
35WNK11.42185581
36TAF11.33650161
37PASK1.29784095
38EIF2AK21.26966893
39MST1R1.24587351
40CHEK11.22767188
41SGK21.20296321
42RPS6KA41.19295757
43WNK41.18390159
44EPHA21.16124811
45MAP2K41.08562953
46AURKA1.08091805
47PNCK1.07901600
48CDK121.07446923
49MAP2K71.06488284
50ATM1.06399497
51STK41.05399020
52TGFBR10.97728321
53BRSK10.95634714
54NME10.95607333
55RPS6KA50.94897035
56CDK80.92265672
57DAPK30.91856227
58NUAK10.88774973
59BRD40.87636154
60PIM10.87563452
61CSNK2A20.87179001
62PDGFRB0.86098070
63SGK30.83345645
64CCNB10.82815893
65CDK40.82583570
66CDK20.82576344
67MAP3K20.81785132
68MAP3K80.81532162
69STK100.80258140
70CSNK2A10.80235254
71TXK0.79705930
72GRK70.79544622
73FGFR10.78163957
74CAMK40.78110039
75CAMK1D0.77640494
76MELK0.75413381
77IRAK40.74553523
78NEK10.73187239
79STK30.70263820
80CDK10.70220346
81STK38L0.69320183
82SGK2230.68311319
83SGK4940.68311319
84MAP3K90.67460412
85STK390.66059923
86TEC0.66036308
87DYRK20.65478775
88BMPR20.64715683
89CDK30.63813401
90MAP2K30.61867462
91PKN10.61410317
92NEK60.60233344
93SCYL20.58943894
94YES10.56585241
95IRAK20.56164068
96MAP3K100.55702306
97MTOR0.55576708
98MAP4K10.54914759
99ADRBK10.54906006
100CLK10.53712544
101MAP3K60.52189740
102RPS6KA60.52033394
103IKBKB0.51661245
104SGK10.51202506
105CAMKK20.50961022
106PRKCI0.50386149
107MAPK150.49244525
108TESK20.49185799
109TGFBR20.48045095
110LATS20.47508304
111IRAK30.44457062
112LATS10.44392031
113MAPK110.43827230
114IKBKE0.43371293
115BMPR1B0.42748676
116RPS6KL10.42365763
117RPS6KC10.42365763
118MET0.41852145
119CAMK1G0.41466241
120PIM20.40752944
121PAK10.40439300
122CSNK1E0.40023189
123GRK10.39924715
124ABL20.38774813
125PRKDC0.37659823
126RPS6KB10.37434723
127AKT30.36676997
128ALK0.36343324
129INSRR0.36246060
130MAP3K140.36245408
131BTK0.32389512
132CDK60.31069698
133BRAF0.30426808
134BCR0.29284991
135MAPK140.28854393
136ADRBK20.28313438
137STK240.27725060
138AKT20.27577413
139CSNK1G30.27538563
140CDK90.27410349
141LYN0.26690830
142CSNK1G10.25900528
143AKT10.23762850
144LCK0.23677868
145CSNK1D0.23188766
146CHUK0.23177648
147MUSK0.21222996
148TRPM70.21065816
149ERBB30.19342537
150NLK0.19128909

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.77843334
2DNA replication_Homo sapiens_hsa030303.98016499
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.92819082
4RNA polymerase_Homo sapiens_hsa030203.91492630
5Mismatch repair_Homo sapiens_hsa034303.75430869
6Spliceosome_Homo sapiens_hsa030403.39270992
7Homologous recombination_Homo sapiens_hsa034403.14957905
8Proteasome_Homo sapiens_hsa030503.07227632
9RNA transport_Homo sapiens_hsa030132.95608576
10Nucleotide excision repair_Homo sapiens_hsa034202.82679547
11Fanconi anemia pathway_Homo sapiens_hsa034602.61087335
12Pyrimidine metabolism_Homo sapiens_hsa002402.48479578
13Base excision repair_Homo sapiens_hsa034102.43985726
14Basal transcription factors_Homo sapiens_hsa030222.39406139
15Cell cycle_Homo sapiens_hsa041102.39185686
16Non-homologous end-joining_Homo sapiens_hsa034502.38385040
17RNA degradation_Homo sapiens_hsa030182.22417383
18One carbon pool by folate_Homo sapiens_hsa006701.89091498
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.76079469
20mRNA surveillance pathway_Homo sapiens_hsa030151.75793341
21Systemic lupus erythematosus_Homo sapiens_hsa053221.57120017
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54731177
23Protein export_Homo sapiens_hsa030601.48351715
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46035007
25p53 signaling pathway_Homo sapiens_hsa041151.45384579
26Purine metabolism_Homo sapiens_hsa002301.42646465
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41507880
28Selenocompound metabolism_Homo sapiens_hsa004501.26444364
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.25057462
30Epstein-Barr virus infection_Homo sapiens_hsa051691.17611912
31Huntingtons disease_Homo sapiens_hsa050161.12422448
32Oxidative phosphorylation_Homo sapiens_hsa001901.06574609
33Dorso-ventral axis formation_Homo sapiens_hsa043201.04540123
34Parkinsons disease_Homo sapiens_hsa050121.01018678
35FoxO signaling pathway_Homo sapiens_hsa040681.00856439
36Circadian rhythm_Homo sapiens_hsa047100.98259493
37Melanoma_Homo sapiens_hsa052180.98099783
38Herpes simplex infection_Homo sapiens_hsa051680.96502597
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92372590
40Bladder cancer_Homo sapiens_hsa052190.88868598
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84350052
42Viral carcinogenesis_Homo sapiens_hsa052030.84306693
43mTOR signaling pathway_Homo sapiens_hsa041500.79753522
44Primary immunodeficiency_Homo sapiens_hsa053400.79383038
45B cell receptor signaling pathway_Homo sapiens_hsa046620.78585428
46ErbB signaling pathway_Homo sapiens_hsa040120.77745147
47Antigen processing and presentation_Homo sapiens_hsa046120.77105956
48MAPK signaling pathway_Homo sapiens_hsa040100.76569942
49Vitamin digestion and absorption_Homo sapiens_hsa049770.72876127
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70000974
51Oocyte meiosis_Homo sapiens_hsa041140.69150725
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68894828
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66098357
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63802006
55TNF signaling pathway_Homo sapiens_hsa046680.63592020
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63581469
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63545145
58Chronic myeloid leukemia_Homo sapiens_hsa052200.63529836
59Alcoholism_Homo sapiens_hsa050340.63138112
60Taste transduction_Homo sapiens_hsa047420.62022369
61MicroRNAs in cancer_Homo sapiens_hsa052060.61893615
62HTLV-I infection_Homo sapiens_hsa051660.61434868
63Allograft rejection_Homo sapiens_hsa053300.60833401
64Inositol phosphate metabolism_Homo sapiens_hsa005620.60396259
65Ovarian steroidogenesis_Homo sapiens_hsa049130.60001671
66Non-small cell lung cancer_Homo sapiens_hsa052230.59148552
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.56940832
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56565279
69GnRH signaling pathway_Homo sapiens_hsa049120.55978238
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.55587467
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55161298
72TGF-beta signaling pathway_Homo sapiens_hsa043500.53376907
73Hematopoietic cell lineage_Homo sapiens_hsa046400.52990007
74Alzheimers disease_Homo sapiens_hsa050100.52942080
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52870310
76Pancreatic cancer_Homo sapiens_hsa052120.52622941
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.51414853
78Lysine degradation_Homo sapiens_hsa003100.50303774
79Prolactin signaling pathway_Homo sapiens_hsa049170.50292432
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49974897
81Vitamin B6 metabolism_Homo sapiens_hsa007500.48829579
82Asthma_Homo sapiens_hsa053100.48431416
83Measles_Homo sapiens_hsa051620.46733156
84Small cell lung cancer_Homo sapiens_hsa052220.46029888
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45760952
86Autoimmune thyroid disease_Homo sapiens_hsa053200.45683351
87ABC transporters_Homo sapiens_hsa020100.45342512
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44718627
89Graft-versus-host disease_Homo sapiens_hsa053320.44602678
90Arachidonic acid metabolism_Homo sapiens_hsa005900.44438215
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43021783
92Renal cell carcinoma_Homo sapiens_hsa052110.42787724
93Basal cell carcinoma_Homo sapiens_hsa052170.39745739
94Hepatitis C_Homo sapiens_hsa051600.39223612
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38869824
96Folate biosynthesis_Homo sapiens_hsa007900.38042924
97Pancreatic secretion_Homo sapiens_hsa049720.37756426
98Glutathione metabolism_Homo sapiens_hsa004800.37684954
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37118568
100Glioma_Homo sapiens_hsa052140.36904995
101Thyroid cancer_Homo sapiens_hsa052160.36839367
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36069813
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34928941
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34898138
105Platelet activation_Homo sapiens_hsa046110.34743665
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33123131
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31871789
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.31158885
109Pentose phosphate pathway_Homo sapiens_hsa000300.30472589
110Apoptosis_Homo sapiens_hsa042100.28987021
111Notch signaling pathway_Homo sapiens_hsa043300.28872289
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28861398
113Legionellosis_Homo sapiens_hsa051340.28638226
114Choline metabolism in cancer_Homo sapiens_hsa052310.28383715
115Hepatitis B_Homo sapiens_hsa051610.27020746
116VEGF signaling pathway_Homo sapiens_hsa043700.26792124
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26038697
118Pathways in cancer_Homo sapiens_hsa052000.25729404
119Proteoglycans in cancer_Homo sapiens_hsa052050.25711568
120Toxoplasmosis_Homo sapiens_hsa051450.25251842
121Hippo signaling pathway_Homo sapiens_hsa043900.23866441
122Influenza A_Homo sapiens_hsa051640.23764074
123Wnt signaling pathway_Homo sapiens_hsa043100.22135295
124Metabolic pathways_Homo sapiens_hsa011000.20521433
125Hedgehog signaling pathway_Homo sapiens_hsa043400.20403936
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.20016102
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.18316200
128Colorectal cancer_Homo sapiens_hsa052100.18216742
129Prostate cancer_Homo sapiens_hsa052150.17193375
130T cell receptor signaling pathway_Homo sapiens_hsa046600.16061288
131Linoleic acid metabolism_Homo sapiens_hsa005910.13880587
132Type I diabetes mellitus_Homo sapiens_hsa049400.12101611
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12033840
134Phototransduction_Homo sapiens_hsa047440.11465268
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10951455
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.09500319
137Sphingolipid metabolism_Homo sapiens_hsa006000.09435849
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08593331
139Shigellosis_Homo sapiens_hsa051310.08241510
140HIF-1 signaling pathway_Homo sapiens_hsa040660.07354691
141Ether lipid metabolism_Homo sapiens_hsa005650.06875415
142Sulfur relay system_Homo sapiens_hsa041220.05807305
143N-Glycan biosynthesis_Homo sapiens_hsa005100.05588931

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