TAF1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus is intronless, and apparently arose in the primate lineage from retrotransposition of the transcript from the multi-exon TAF1 locus on the X chromosome. The gene is expressed in male germ cells, and the product has been shown to function interchangeably with the TAF1 product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.93448048
2response to pheromone (GO:0019236)4.88118122
3sperm motility (GO:0030317)4.27893383
4acrosome reaction (GO:0007340)4.25720116
5DNA deamination (GO:0045006)4.15686767
6regulation of cilium movement (GO:0003352)4.08096404
7fucose catabolic process (GO:0019317)3.97347480
8L-fucose metabolic process (GO:0042354)3.97347480
9L-fucose catabolic process (GO:0042355)3.97347480
10piRNA metabolic process (GO:0034587)3.88858924
11indolalkylamine metabolic process (GO:0006586)3.79449135
12detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.75472849
13tryptophan catabolic process (GO:0006569)3.73405043
14indole-containing compound catabolic process (GO:0042436)3.73405043
15indolalkylamine catabolic process (GO:0046218)3.73405043
16protein polyglutamylation (GO:0018095)3.70711564
17cellular ketone body metabolic process (GO:0046950)3.64251117
18platelet dense granule organization (GO:0060155)3.63205846
19axoneme assembly (GO:0035082)3.52948885
20multicellular organism reproduction (GO:0032504)3.52874684
21epithelial cilium movement (GO:0003351)3.48918287
22tryptophan metabolic process (GO:0006568)3.43016060
23ketone body metabolic process (GO:1902224)3.36579921
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.32832297
25fusion of sperm to egg plasma membrane (GO:0007342)3.23623680
26respiratory chain complex IV assembly (GO:0008535)3.22438719
27water-soluble vitamin biosynthetic process (GO:0042364)3.16982520
28DNA methylation involved in gamete generation (GO:0043046)3.09434076
29spermatid development (GO:0007286)3.08916988
30protein K11-linked deubiquitination (GO:0035871)3.08258318
31cilium or flagellum-dependent cell motility (GO:0001539)3.06141814
32mannosylation (GO:0097502)3.06059083
33detection of light stimulus involved in sensory perception (GO:0050962)3.04209723
34detection of light stimulus involved in visual perception (GO:0050908)3.04209723
35kynurenine metabolic process (GO:0070189)3.01785426
36regulation of action potential (GO:0098900)2.98209036
37auditory receptor cell stereocilium organization (GO:0060088)2.97575415
38proline transport (GO:0015824)2.96848652
39regulation of hexokinase activity (GO:1903299)2.93904124
40regulation of glucokinase activity (GO:0033131)2.93904124
41* male meiosis (GO:0007140)2.92326291
42centriole replication (GO:0007099)2.90221559
43protein-cofactor linkage (GO:0018065)2.88626262
44establishment of protein localization to Golgi (GO:0072600)2.88023869
45cilium morphogenesis (GO:0060271)2.87829529
46G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.87506609
47cilium movement (GO:0003341)2.86887222
48rRNA modification (GO:0000154)2.86527100
49protein complex biogenesis (GO:0070271)2.85961916
50negative regulation of telomere maintenance (GO:0032205)2.85360719
51neuronal action potential (GO:0019228)2.82593799
52alanine transport (GO:0032328)2.81684486
53regulation of microtubule-based movement (GO:0060632)2.81038043
54cytochrome complex assembly (GO:0017004)2.80561805
55cornea development in camera-type eye (GO:0061303)2.80537803
56cilium organization (GO:0044782)2.78152334
57rRNA methylation (GO:0031167)2.77927846
58male meiosis I (GO:0007141)2.77655615
59negative regulation of synaptic transmission, GABAergic (GO:0032229)2.76825732
60positive regulation of fatty acid transport (GO:2000193)2.75681510
61photoreceptor cell maintenance (GO:0045494)2.74805455
62sperm-egg recognition (GO:0035036)2.74697482
63neural tube formation (GO:0001841)2.74284800
64positive regulation of prostaglandin secretion (GO:0032308)2.73974865
65nonmotile primary cilium assembly (GO:0035058)2.73960729
66nephron epithelium morphogenesis (GO:0072088)2.73883705
67nephron tubule morphogenesis (GO:0072078)2.73883705
68negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73763366
69indole-containing compound metabolic process (GO:0042430)2.73093887
70adaptation of signaling pathway (GO:0023058)2.71894891
71protein targeting to Golgi (GO:0000042)2.71852189
72cilium assembly (GO:0042384)2.70307861
73mitochondrial respiratory chain complex I assembly (GO:0032981)2.69979625
74NADH dehydrogenase complex assembly (GO:0010257)2.69979625
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.69979625
76protein localization to cilium (GO:0061512)2.69302155
77plasma membrane fusion (GO:0045026)2.65392768
78preassembly of GPI anchor in ER membrane (GO:0016254)2.65332903
79organic cation transport (GO:0015695)2.64143908
80gamma-aminobutyric acid transport (GO:0015812)2.62613358
81cellular biogenic amine catabolic process (GO:0042402)2.62309377
82amine catabolic process (GO:0009310)2.62309377
83mitochondrial respiratory chain complex assembly (GO:0033108)2.62063156
84calcium ion-dependent exocytosis (GO:0017156)2.61491217
85seminiferous tubule development (GO:0072520)2.59191949
86S-adenosylmethionine metabolic process (GO:0046500)2.58763899
87reflex (GO:0060004)2.56503041
88cAMP catabolic process (GO:0006198)2.55008878
89axonemal dynein complex assembly (GO:0070286)2.54526378
90inner ear receptor stereocilium organization (GO:0060122)2.54099541
91ubiquinone biosynthetic process (GO:0006744)2.52359064
92retinal cone cell development (GO:0046549)2.47674998
93single strand break repair (GO:0000012)2.44934375
94microtubule depolymerization (GO:0007019)2.44827111
95synaptic transmission, cholinergic (GO:0007271)2.44230473
96spinal cord motor neuron differentiation (GO:0021522)2.43840894
97kidney morphogenesis (GO:0060993)2.43783555
98behavioral response to ethanol (GO:0048149)2.43469029
99GPI anchor metabolic process (GO:0006505)2.43214490
100rRNA catabolic process (GO:0016075)2.42926722

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.01872447
2GBX2_23144817_ChIP-Seq_PC3_Human3.07467376
3VDR_22108803_ChIP-Seq_LS180_Human3.05423523
4IGF1R_20145208_ChIP-Seq_DFB_Human2.90094149
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75229987
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.38753095
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38470630
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.34943263
9EZH2_22144423_ChIP-Seq_EOC_Human2.32498843
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29322042
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.27501749
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.26425187
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22805122
14FUS_26573619_Chip-Seq_HEK293_Human2.16914317
15P300_19829295_ChIP-Seq_ESCs_Human2.04404977
16ER_23166858_ChIP-Seq_MCF-7_Human2.03987897
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92366136
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.87016041
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85076211
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84281201
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.82781176
22CBP_20019798_ChIP-Seq_JUKART_Human1.74331731
23IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.74331731
24TAF15_26573619_Chip-Seq_HEK293_Human1.73360494
25EWS_26573619_Chip-Seq_HEK293_Human1.72429182
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68800738
27TP53_22573176_ChIP-Seq_HFKS_Human1.65707394
28BCAT_22108803_ChIP-Seq_LS180_Human1.63160947
29NANOG_19829295_ChIP-Seq_ESCs_Human1.59395179
30SOX2_19829295_ChIP-Seq_ESCs_Human1.59395179
31SMAD4_21799915_ChIP-Seq_A2780_Human1.53699511
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48858715
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48654411
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47103596
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46652683
36STAT3_23295773_ChIP-Seq_U87_Human1.44611947
37AR_25329375_ChIP-Seq_VCAP_Human1.44391084
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41823379
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40137251
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40137251
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39410902
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39298302
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.37341525
44KLF5_20875108_ChIP-Seq_MESCs_Mouse1.37222945
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36445379
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.34522580
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34105187
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.33925115
49TCF4_23295773_ChIP-Seq_U87_Human1.33585756
50TCF4_22108803_ChIP-Seq_LS180_Human1.33077925
51IRF1_19129219_ChIP-ChIP_H3396_Human1.32420092
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.32393401
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31890880
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30968011
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30876470
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.30213859
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.30026080
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30026080
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29942372
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29087375
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28513685
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27351815
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27335650
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26986597
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.26156062
66MYC_18940864_ChIP-ChIP_HL60_Human1.25466125
67RUNX2_22187159_ChIP-Seq_PCA_Human1.25202412
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.24377958
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23996150
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.19574677
71AR_20517297_ChIP-Seq_VCAP_Human1.19158286
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18576386
73NCOR_22424771_ChIP-Seq_293T_Human1.18446869
74REST_21632747_ChIP-Seq_MESCs_Mouse1.17255770
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.16024692
76* MYC_19829295_ChIP-Seq_ESCs_Human1.14979878
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.13993253
78HOXB7_26014856_ChIP-Seq_BT474_Human1.13610658
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.10391590
80ERA_21632823_ChIP-Seq_H3396_Human1.10180585
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10083750
82CDX2_22108803_ChIP-Seq_LS180_Human1.10076980
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.08960837
84NANOG_20526341_ChIP-Seq_ESCs_Human1.08827040
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08496973
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.07885726
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06576261
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.05791532
89FOXH1_21741376_ChIP-Seq_EPCs_Human1.05677920
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04954025
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02290545
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01387586
93RNF2_27304074_Chip-Seq_NSC_Mouse1.01237332
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01210236
95P53_22387025_ChIP-Seq_ESCs_Mouse1.00099595
96STAT3_18555785_Chip-Seq_ESCs_Mouse0.98705759
97ELK1_19687146_ChIP-ChIP_HELA_Human0.96754770
98TAF2_19829295_ChIP-Seq_ESCs_Human0.95182449
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94907116
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94705140

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.35825615
2MP0005410_abnormal_fertilization2.94785147
3MP0003195_calcinosis2.90707416
4MP0002102_abnormal_ear_morphology2.73944547
5MP0005551_abnormal_eye_electrophysiolog2.60402950
6MP0001501_abnormal_sleep_pattern2.29011253
7MP0001968_abnormal_touch/_nociception2.15962740
8MP0000569_abnormal_digit_pigmentation2.14720345
9MP0003787_abnormal_imprinting2.14663241
10MP0000372_irregular_coat_pigmentation2.13417668
11MP0003646_muscle_fatigue2.12313292
12MP0009046_muscle_twitch2.08581113
13MP0006072_abnormal_retinal_apoptosis2.08429917
14MP0002837_dystrophic_cardiac_calcinosis2.05483133
15MP0005253_abnormal_eye_physiology1.90912708
16MP0002876_abnormal_thyroid_physiology1.80680832
17MP0001986_abnormal_taste_sensitivity1.80678703
18MP0006276_abnormal_autonomic_nervous1.79491579
19MP0008872_abnormal_physiological_respon1.78614125
20MP0002736_abnormal_nociception_after1.78582458
21MP0004043_abnormal_pH_regulation1.76565137
22MP0001984_abnormal_olfaction1.75297662
23MP0005645_abnormal_hypothalamus_physiol1.74778544
24MP0003011_delayed_dark_adaptation1.74026661
25MP0002272_abnormal_nervous_system1.69271860
26MP0009745_abnormal_behavioral_response1.67294197
27MP0000427_abnormal_hair_cycle1.67182603
28MP0005084_abnormal_gallbladder_morpholo1.64071613
29MP0004885_abnormal_endolymph1.63052808
30MP0004147_increased_porphyrin_level1.62098548
31MP0003880_abnormal_central_pattern1.62023106
32MP0002638_abnormal_pupillary_reflex1.60956605
33MP0008875_abnormal_xenobiotic_pharmacok1.55203703
34MP0002234_abnormal_pharynx_morphology1.54350377
35MP0004142_abnormal_muscle_tone1.50218606
36MP0003698_abnormal_male_reproductive1.47478636
37MP0000631_abnormal_neuroendocrine_gland1.43764002
38MP0005646_abnormal_pituitary_gland1.42171187
39MP0001486_abnormal_startle_reflex1.34875237
40MP0003878_abnormal_ear_physiology1.30339149
41MP0005377_hearing/vestibular/ear_phenot1.30339149
42MP0003718_maternal_effect1.29829136
43MP0004133_heterotaxia1.29688625
44MP0002938_white_spotting1.28263158
45MP0002572_abnormal_emotion/affect_behav1.26588567
46MP0001929_abnormal_gametogenesis1.26318952
47MP0002557_abnormal_social/conspecific_i1.25324460
48MP0006292_abnormal_olfactory_placode1.23926867
49MP0008995_early_reproductive_senescence1.23008210
50MP0001529_abnormal_vocalization1.22413865
51MP0004742_abnormal_vestibular_system1.22014385
52MP0001485_abnormal_pinna_reflex1.19911682
53MP0002653_abnormal_ependyma_morphology1.18784238
54MP0005075_abnormal_melanosome_morpholog1.16489589
55MP0002160_abnormal_reproductive_system1.15468014
56MP0005379_endocrine/exocrine_gland_phen1.14676364
57MP0002064_seizures1.14331353
58MP0004924_abnormal_behavior1.13792437
59MP0005386_behavior/neurological_phenoty1.13792437
60MP0005389_reproductive_system_phenotype1.12831842
61MP0002909_abnormal_adrenal_gland1.12396591
62MP0001905_abnormal_dopamine_level1.10790335
63MP0008789_abnormal_olfactory_epithelium1.08639202
64MP0001502_abnormal_circadian_rhythm1.07688809
65MP0002733_abnormal_thermal_nociception1.07062438
66MP0010386_abnormal_urinary_bladder1.04866786
67MP0000383_abnormal_hair_follicle1.04793421
68MP0005174_abnormal_tail_pigmentation1.04038450
69MP0002067_abnormal_sensory_capabilities0.99925985
70MP0001970_abnormal_pain_threshold0.98805575
71MP0002254_reproductive_system_inflammat0.97616960
72MP0003121_genomic_imprinting0.96502694
73MP0002163_abnormal_gland_morphology0.95862359
74MP0001919_abnormal_reproductive_system0.95843242
75MP0002928_abnormal_bile_duct0.95808763
76MP0002229_neurodegeneration0.95401253
77MP0005195_abnormal_posterior_eye0.94807512
78MP0002735_abnormal_chemical_nociception0.93619338
79MP0003283_abnormal_digestive_organ0.92315191
80MP0008058_abnormal_DNA_repair0.91241669
81MP0005670_abnormal_white_adipose0.89328761
82MP0001963_abnormal_hearing_physiology0.87984081
83MP0002210_abnormal_sex_determination0.87744535
84MP0000230_abnormal_systemic_arterial0.87719327
85MP0003635_abnormal_synaptic_transmissio0.85307844
86MP0009780_abnormal_chondrocyte_physiolo0.84149167
87MP0005367_renal/urinary_system_phenotyp0.83844245
88MP0000516_abnormal_urinary_system0.83844245
89MP0002734_abnormal_mechanical_nocicepti0.83434906
90MP0002095_abnormal_skin_pigmentation0.83075714
91MP0002752_abnormal_somatic_nervous0.82506525
92MP0005394_taste/olfaction_phenotype0.81919326
93MP0005499_abnormal_olfactory_system0.81919326
94MP0001764_abnormal_homeostasis0.81409502
95MP0004145_abnormal_muscle_electrophysio0.81002408
96MP0000026_abnormal_inner_ear0.80444315
97MP0002751_abnormal_autonomic_nervous0.80010773
98MP0002063_abnormal_learning/memory/cond0.79781191
99MP0000653_abnormal_sex_gland0.79754812
100MP0002277_abnormal_respiratory_mucosa0.79563625

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.15897422
2Molar tooth sign on MRI (HP:0002419)3.90700723
3Abnormality of midbrain morphology (HP:0002418)3.90700723
4Pancreatic fibrosis (HP:0100732)3.86932150
5Congenital stationary night blindness (HP:0007642)3.85716975
6Nephronophthisis (HP:0000090)3.71234637
7True hermaphroditism (HP:0010459)3.57668724
8Type II lissencephaly (HP:0007260)3.57332991
9Abnormality of the renal cortex (HP:0011035)3.39673740
10Attenuation of retinal blood vessels (HP:0007843)3.35905514
11Chronic hepatic failure (HP:0100626)3.27793863
12Abnormality of the renal medulla (HP:0100957)3.23365678
13Abnormal rod and cone electroretinograms (HP:0008323)3.07257816
14Hypothermia (HP:0002045)2.93131831
15Tubular atrophy (HP:0000092)2.91077642
16Medial flaring of the eyebrow (HP:0010747)2.85768555
17Hyperventilation (HP:0002883)2.78537909
18Inability to walk (HP:0002540)2.72104509
19Polydipsia (HP:0001959)2.71554902
20Abnormal drinking behavior (HP:0030082)2.71554902
21Cystic liver disease (HP:0006706)2.71031787
22Dynein arm defect of respiratory motile cilia (HP:0012255)2.68593031
23Absent/shortened dynein arms (HP:0200106)2.68593031
24Renal cortical cysts (HP:0000803)2.64241379
25Abnormality of the labia minora (HP:0012880)2.59000280
26Acute necrotizing encephalopathy (HP:0006965)2.55261974
27Pendular nystagmus (HP:0012043)2.55188471
28Abolished electroretinogram (ERG) (HP:0000550)2.48305591
29Bony spicule pigmentary retinopathy (HP:0007737)2.48266657
30Progressive inability to walk (HP:0002505)2.48137198
31Lissencephaly (HP:0001339)2.45877299
32Retinal dysplasia (HP:0007973)2.44696659
333-Methylglutaconic aciduria (HP:0003535)2.42922696
34Mitochondrial inheritance (HP:0001427)2.39452478
35Acute encephalopathy (HP:0006846)2.38771519
36Keratoconus (HP:0000563)2.37931277
37Increased corneal curvature (HP:0100692)2.37931277
38Progressive macrocephaly (HP:0004481)2.36527203
39Hypomagnesemia (HP:0002917)2.31150225
40Increased CSF lactate (HP:0002490)2.30375606
41Abnormal biliary tract physiology (HP:0012439)2.27822697
42Bile duct proliferation (HP:0001408)2.27822697
43Polyuria (HP:0000103)2.25461623
44Gait imbalance (HP:0002141)2.25120466
45Optic disc pallor (HP:0000543)2.24398293
46Large for gestational age (HP:0001520)2.22784494
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22055206
48Aplasia/Hypoplasia of the fovea (HP:0008060)2.22028623
49Hypoplasia of the fovea (HP:0007750)2.22028623
50Aplasia/Hypoplasia of the tongue (HP:0010295)2.18235692
51Congenital primary aphakia (HP:0007707)2.17785355
52Progressive cerebellar ataxia (HP:0002073)2.17778633
53Male pseudohermaphroditism (HP:0000037)2.17770077
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17061787
55Decreased central vision (HP:0007663)2.16972314
56Cerebellar dysplasia (HP:0007033)2.16709851
57Gaze-evoked nystagmus (HP:0000640)2.14838814
58Ketoacidosis (HP:0001993)2.09995454
59Sclerocornea (HP:0000647)2.09384532
60Optic nerve hypoplasia (HP:0000609)2.08959202
61Hepatocellular necrosis (HP:0001404)2.07134435
62Febrile seizures (HP:0002373)2.06482340
63Abnormal mitochondria in muscle tissue (HP:0008316)2.06317260
64Hepatic necrosis (HP:0002605)2.05583265
65Broad-based gait (HP:0002136)2.05578007
66Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04996117
67Nephrogenic diabetes insipidus (HP:0009806)2.04157778
68Aplasia/hypoplasia of the uterus (HP:0008684)2.03659042
69Anencephaly (HP:0002323)2.01987183
70Postaxial foot polydactyly (HP:0001830)2.00103940
71Aplasia/Hypoplasia of the tibia (HP:0005772)2.00092043
72Abnormal ciliary motility (HP:0012262)1.99007175
73Abnormality of macular pigmentation (HP:0008002)1.96826900
74Abnormal respiratory motile cilium morphology (HP:0005938)1.96518366
75Abnormal respiratory epithelium morphology (HP:0012253)1.96518366
76Limb dystonia (HP:0002451)1.95017158
77Genital tract atresia (HP:0001827)1.93492233
78Congenital sensorineural hearing impairment (HP:0008527)1.91957244
79Intestinal atresia (HP:0011100)1.91454576
80Ketosis (HP:0001946)1.90776989
81Tubulointerstitial nephritis (HP:0001970)1.89337606
82Pachygyria (HP:0001302)1.88825301
83Furrowed tongue (HP:0000221)1.88454709
84Type 2 muscle fiber atrophy (HP:0003554)1.88267113
85Lipid accumulation in hepatocytes (HP:0006561)1.87835991
86Congenital hepatic fibrosis (HP:0002612)1.87580758
87Hemiparesis (HP:0001269)1.87578844
88Occipital encephalocele (HP:0002085)1.87186121
89Abnormality of the fovea (HP:0000493)1.84727413
90Congenital, generalized hypertrichosis (HP:0004540)1.84386647
91Abnormal urine output (HP:0012590)1.83852190
92Absent speech (HP:0001344)1.81797249
93Vaginal atresia (HP:0000148)1.77705714
94Abnormal respiratory motile cilium physiology (HP:0012261)1.75230916
95Short tibia (HP:0005736)1.74743061
96Disproportionate short-trunk short stature (HP:0003521)1.73141670
97Tubulointerstitial abnormality (HP:0001969)1.73088917
98Increased hepatocellular lipid droplets (HP:0006565)1.71612262
99Tachypnea (HP:0002789)1.71421545
100Chorioretinal atrophy (HP:0000533)1.70717416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.79728861
2FRK4.72289343
3PINK13.13985146
4TAOK32.74743146
5ADRBK22.73357075
6WNK32.56324646
7NUAK12.46479004
8INSRR2.30999119
9GRK12.30188032
10BMPR1B2.17594686
11ZAK2.07869671
12TLK11.86692495
13TRIM281.77543627
14MAPK131.69344886
15WNK41.64801566
16STK38L1.56790010
17PLK41.46590665
18MAP3K41.46053970
19CASK1.42187585
20TXK1.40443315
21PLK21.36752523
22VRK21.33047791
23OXSR11.29766789
24DYRK21.26886170
25MUSK1.22053078
26TNIK1.20831918
27PAK31.19489890
28PHKG21.18435274
29PHKG11.18435274
30BCKDK1.18217525
31DAPK21.17745738
32EIF2AK31.13845845
33MARK11.13285936
34MAP3K121.11476012
35FGFR21.09231056
36MAP2K71.07379238
37CAMKK21.04290943
38CSNK1G31.03847139
39BCR1.03411006
40CSNK1G11.03378957
41CSNK1G21.01733608
42ACVR1B1.00850503
43PRKCE0.98486749
44VRK10.96136908
45NEK20.94700593
46PRKCG0.85888217
47STK390.82056504
48ADRBK10.80789357
49AKT30.80775060
50PTK2B0.80221155
51BRSK20.80046971
52CSNK1A1L0.78200191
53MAPKAPK50.75938982
54TIE10.75762825
55MST40.72972335
56ERBB30.71675002
57MARK30.69626037
58MKNK20.68638159
59EPHA40.66827698
60NTRK30.64445078
61STK380.62239648
62NTRK20.60849099
63PLK30.58998142
64CAMK2A0.58225427
65PRKCQ0.57245994
66TAF10.56319643
67EIF2AK10.54127273
68PKN10.53812225
69RPS6KA50.53092389
70SIK20.52939915
71CSNK1A10.51099137
72MAP2K60.49471163
73PIK3CG0.48264031
74PNCK0.47978983
75CAMK10.46267879
76NEK10.46170862
77PIK3CA0.45061494
78PRKACA0.44427052
79OBSCN0.44314770
80FER0.43793979
81PRKAA20.43281703
82PRKCI0.42613230
83PRKG10.41788791
84MINK10.41470526
85KIT0.41235190
86TGFBR10.37282454
87PRKAA10.36742825
88IKBKB0.36356318
89PRKCZ0.35917162
90MKNK10.35892722
91NLK0.35020217
92PRKCA0.34917799
93STK110.34035649
94CCNB10.32809424
95MAPKAPK30.32655534
96STK160.31942415
97STK30.30491470
98EIF2AK20.30332114
99NME10.28739223
100CAMK1G0.28736441

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.90457809
2Phototransduction_Homo sapiens_hsa047442.80728269
3Butanoate metabolism_Homo sapiens_hsa006502.66396883
4Linoleic acid metabolism_Homo sapiens_hsa005912.53988589
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.38224916
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.34109432
7Protein export_Homo sapiens_hsa030602.33367274
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.33270837
9Oxidative phosphorylation_Homo sapiens_hsa001902.30527017
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23227274
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21032510
12Nitrogen metabolism_Homo sapiens_hsa009102.15589004
13Nicotine addiction_Homo sapiens_hsa050332.03626597
14Selenocompound metabolism_Homo sapiens_hsa004501.98928203
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.90079805
16Tryptophan metabolism_Homo sapiens_hsa003801.82500450
17Caffeine metabolism_Homo sapiens_hsa002321.77024582
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76375121
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74686519
20Propanoate metabolism_Homo sapiens_hsa006401.69234639
21* Basal transcription factors_Homo sapiens_hsa030221.67310657
22Parkinsons disease_Homo sapiens_hsa050121.67076609
23Ether lipid metabolism_Homo sapiens_hsa005651.62270448
24Homologous recombination_Homo sapiens_hsa034401.55766985
25Olfactory transduction_Homo sapiens_hsa047401.49310154
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48386138
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46540742
28RNA polymerase_Homo sapiens_hsa030201.45348800
29Fanconi anemia pathway_Homo sapiens_hsa034601.44790187
30Proteasome_Homo sapiens_hsa030501.35470457
31Taste transduction_Homo sapiens_hsa047421.31901441
32Regulation of autophagy_Homo sapiens_hsa041401.19707777
33Cardiac muscle contraction_Homo sapiens_hsa042601.17823409
34Morphine addiction_Homo sapiens_hsa050321.16801634
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16499374
36Peroxisome_Homo sapiens_hsa041461.15824592
37Huntingtons disease_Homo sapiens_hsa050161.14854230
38ABC transporters_Homo sapiens_hsa020101.13699377
39RNA degradation_Homo sapiens_hsa030181.11031695
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.06253578
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03682280
42Arachidonic acid metabolism_Homo sapiens_hsa005901.00942391
43Alzheimers disease_Homo sapiens_hsa050101.00068941
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99237556
45Chemical carcinogenesis_Homo sapiens_hsa052040.99090235
46One carbon pool by folate_Homo sapiens_hsa006700.98512677
47Salivary secretion_Homo sapiens_hsa049700.97243710
48Retinol metabolism_Homo sapiens_hsa008300.96726591
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96713827
50Insulin secretion_Homo sapiens_hsa049110.92966572
51Circadian rhythm_Homo sapiens_hsa047100.92417687
52GABAergic synapse_Homo sapiens_hsa047270.91321247
53Collecting duct acid secretion_Homo sapiens_hsa049660.88656143
54Non-homologous end-joining_Homo sapiens_hsa034500.84010257
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83403723
56Purine metabolism_Homo sapiens_hsa002300.82952145
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82816758
58Circadian entrainment_Homo sapiens_hsa047130.81959963
59Fat digestion and absorption_Homo sapiens_hsa049750.80214600
60Steroid biosynthesis_Homo sapiens_hsa001000.80139694
61Serotonergic synapse_Homo sapiens_hsa047260.77593776
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.76350109
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74927253
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74004892
65Metabolic pathways_Homo sapiens_hsa011000.73459357
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73300969
67Ovarian steroidogenesis_Homo sapiens_hsa049130.72811838
68Fatty acid elongation_Homo sapiens_hsa000620.71913126
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.71642556
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69610117
71Type I diabetes mellitus_Homo sapiens_hsa049400.69555395
72Sulfur metabolism_Homo sapiens_hsa009200.69383412
73beta-Alanine metabolism_Homo sapiens_hsa004100.66634052
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.65386030
75Glutamatergic synapse_Homo sapiens_hsa047240.64880518
76Vitamin B6 metabolism_Homo sapiens_hsa007500.60005440
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.57320876
78Fatty acid biosynthesis_Homo sapiens_hsa000610.56747413
79Glycerolipid metabolism_Homo sapiens_hsa005610.56459840
80Calcium signaling pathway_Homo sapiens_hsa040200.55567709
81Fatty acid degradation_Homo sapiens_hsa000710.55443365
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54542616
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53611378
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51934792
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51147391
86Histidine metabolism_Homo sapiens_hsa003400.50847203
87Mineral absorption_Homo sapiens_hsa049780.50099555
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.47973221
89Fatty acid metabolism_Homo sapiens_hsa012120.45651776
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43053256
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42971327
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42862275
93Pyrimidine metabolism_Homo sapiens_hsa002400.41354855
94Arginine and proline metabolism_Homo sapiens_hsa003300.41104737
95Hedgehog signaling pathway_Homo sapiens_hsa043400.40981243
96Nucleotide excision repair_Homo sapiens_hsa034200.36517976
97Synaptic vesicle cycle_Homo sapiens_hsa047210.34555068
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33918826
99Sphingolipid metabolism_Homo sapiens_hsa006000.32635858
100Long-term depression_Homo sapiens_hsa047300.32075744

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