TAF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.18121144
2nuclear pore organization (GO:0006999)5.87356512
3mitotic sister chromatid cohesion (GO:0007064)5.23255428
4DNA unwinding involved in DNA replication (GO:0006268)4.80201883
5pore complex assembly (GO:0046931)4.53486480
6protein localization to kinetochore (GO:0034501)4.48192542
7pre-miRNA processing (GO:0031054)4.41293918
8mitotic nuclear envelope disassembly (GO:0007077)4.26455074
9DNA double-strand break processing (GO:0000729)4.21295804
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.19877551
11regulation of RNA export from nucleus (GO:0046831)4.18994077
12mitotic chromosome condensation (GO:0007076)4.11668365
13nuclear envelope disassembly (GO:0051081)4.03458854
14membrane disassembly (GO:0030397)4.03458854
15sister chromatid segregation (GO:0000819)3.90733147
16protein localization to chromosome, centromeric region (GO:0071459)3.87953284
17regulation of histone H3-K9 methylation (GO:0051570)3.85286784
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.84700548
19negative regulation of histone methylation (GO:0031061)3.84268077
20non-recombinational repair (GO:0000726)3.77492018
21double-strand break repair via nonhomologous end joining (GO:0006303)3.77492018
22histone-serine phosphorylation (GO:0035404)3.75182595
23monoubiquitinated protein deubiquitination (GO:0035520)3.69248832
24regulation of spindle organization (GO:0090224)3.66149087
25regulation of sister chromatid cohesion (GO:0007063)3.65737768
26CENP-A containing nucleosome assembly (GO:0034080)3.65737543
27heterochromatin organization (GO:0070828)3.64861277
28chromatin remodeling at centromere (GO:0031055)3.62056595
29DNA geometric change (GO:0032392)3.61379686
30ribosome assembly (GO:0042255)3.60965575
31DNA duplex unwinding (GO:0032508)3.58794065
32DNA replication-dependent nucleosome assembly (GO:0006335)3.58122593
33DNA replication-dependent nucleosome organization (GO:0034723)3.58122593
34positive regulation of chromosome segregation (GO:0051984)3.55056147
35mitotic sister chromatid segregation (GO:0000070)3.54450342
36kinetochore organization (GO:0051383)3.54374281
37mitotic metaphase plate congression (GO:0007080)3.52604349
38gene silencing by RNA (GO:0031047)3.49189518
39dosage compensation (GO:0007549)3.44988324
40regulation of mitotic spindle organization (GO:0060236)3.37462889
41positive regulation of mitotic sister chromatid separation (GO:1901970)3.36093419
42positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.36093419
43positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.36093419
44protein localization to chromosome (GO:0034502)3.31647474
45mitotic spindle organization (GO:0007052)3.31013795
46DNA replication initiation (GO:0006270)3.28583548
47metaphase plate congression (GO:0051310)3.28015806
48regulation of nucleobase-containing compound transport (GO:0032239)3.27767080
49regulation of centriole replication (GO:0046599)3.24293907
50regulation of chromosome segregation (GO:0051983)3.24152077
51chromatin assembly (GO:0031497)3.23089998
52nuclear envelope organization (GO:0006998)3.22414526
53negative regulation of DNA-dependent DNA replication (GO:2000104)3.20582326
54regulation of DNA endoreduplication (GO:0032875)3.17923016
55regulation of centrosome cycle (GO:0046605)3.17770010
56negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.16766085
57attachment of spindle microtubules to kinetochore (GO:0008608)3.16686761
58peptidyl-lysine dimethylation (GO:0018027)3.15511097
59sister chromatid cohesion (GO:0007062)3.12879499
60IMP biosynthetic process (GO:0006188)3.12325687
61telomere maintenance via semi-conservative replication (GO:0032201)3.12318206
62protein prenylation (GO:0018342)3.12188977
63prenylation (GO:0097354)3.12188977
64regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11177993
65DNA replication checkpoint (GO:0000076)3.08576376
66spindle checkpoint (GO:0031577)3.08512912
67spindle assembly checkpoint (GO:0071173)3.08393463
68DNA conformation change (GO:0071103)3.08184563
69negative regulation of DNA repair (GO:0045738)3.07553787
70mitotic recombination (GO:0006312)3.05763612
71meiotic chromosome segregation (GO:0045132)3.05677608
72glucocorticoid receptor signaling pathway (GO:0042921)3.05641070
73chromatin assembly or disassembly (GO:0006333)3.05276300
74histone mRNA catabolic process (GO:0071044)3.04994504
75negative regulation of chromosome segregation (GO:0051985)3.04758611
76histone exchange (GO:0043486)3.03576752
77postreplication repair (GO:0006301)3.03396297
78regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02720083
79DNA ligation (GO:0006266)3.02518783
80replication fork processing (GO:0031297)3.02384172
81DNA topological change (GO:0006265)3.02047843
82mitotic spindle assembly checkpoint (GO:0007094)3.01985093
83mRNA stabilization (GO:0048255)3.01349825
84RNA stabilization (GO:0043489)3.01349825
85mitotic spindle checkpoint (GO:0071174)3.00506883
86DNA strand elongation involved in DNA replication (GO:0006271)2.99885486
87DNA catabolic process, exonucleolytic (GO:0000738)2.99367802
88translesion synthesis (GO:0019985)2.98355457
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97808707
90negative regulation of sister chromatid segregation (GO:0033046)2.97808707
91negative regulation of mitotic sister chromatid separation (GO:2000816)2.97808707
92negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97808707
93telomere maintenance via recombination (GO:0000722)2.97512163
94gene silencing (GO:0016458)2.96719892
95regulation of translational termination (GO:0006449)2.96104656
96ATP-dependent chromatin remodeling (GO:0043044)2.94377652
97establishment of integrated proviral latency (GO:0075713)2.93915854
98somatic hypermutation of immunoglobulin genes (GO:0016446)2.93763828
99somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93763828
100regulation of centrosome duplication (GO:0010824)2.92943434
101regulation of sister chromatid segregation (GO:0033045)2.92674719
102regulation of mitotic sister chromatid separation (GO:0010965)2.92674719
103regulation of mitotic sister chromatid segregation (GO:0033047)2.92674719
104NLS-bearing protein import into nucleus (GO:0006607)2.91752404
105mRNA transport (GO:0051028)2.91227557
106regulation of double-strand break repair (GO:2000779)2.90088689
107regulation of translational fidelity (GO:0006450)2.89734073
108DNA strand elongation (GO:0022616)2.89718542
109chromosome condensation (GO:0030261)2.89203959
110DNA replication-independent nucleosome assembly (GO:0006336)2.89155073
111DNA replication-independent nucleosome organization (GO:0034724)2.89155073
112regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88342893
113establishment of chromosome localization (GO:0051303)2.87507467
114negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87256391
115spindle assembly (GO:0051225)2.87041570
116nucleotide-excision repair, DNA gap filling (GO:0006297)2.85080191
117positive regulation of histone H3-K4 methylation (GO:0051571)2.84877012
118resolution of meiotic recombination intermediates (GO:0000712)2.84773134
119synaptonemal complex assembly (GO:0007130)2.83390214
120DNA packaging (GO:0006323)2.82734072
121piRNA metabolic process (GO:0034587)2.81769444
122chromosome segregation (GO:0007059)2.81709703
123nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.81588259
124histone H3-K9 methylation (GO:0051567)2.80484396
125kinetochore assembly (GO:0051382)2.80090713
126negative regulation of RNA splicing (GO:0033119)2.77925046
127regulation of spindle checkpoint (GO:0090231)2.77038341
128double-strand break repair (GO:0006302)2.76934561
129mitotic G2/M transition checkpoint (GO:0044818)2.75983379
130response to X-ray (GO:0010165)2.75750120
131maturation of 5.8S rRNA (GO:0000460)2.75264657
132mitotic cell cycle (GO:0000278)2.72971047

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.98281986
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.39880456
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.27162602
4* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.37677825
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.35818747
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.96864030
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.96497918
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.94459604
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.86049918
10AR_21909140_ChIP-Seq_LNCAP_Human2.67653239
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.59553912
12MYC_22102868_ChIP-Seq_BL_Human2.46262239
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.36498624
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34496100
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16491085
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.13784080
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09068373
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07125801
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05269451
20EWS_26573619_Chip-Seq_HEK293_Human2.02578196
21E2F7_22180533_ChIP-Seq_HELA_Human10.9774298
22MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96513237
23FUS_26573619_Chip-Seq_HEK293_Human1.92949126
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91826695
25* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88242034
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85553758
27* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80655781
28TAF15_26573619_Chip-Seq_HEK293_Human1.77562613
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75421826
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67789835
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.65957337
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61043762
33ZNF274_21170338_ChIP-Seq_K562_Hela1.60746673
34XRN2_22483619_ChIP-Seq_HELA_Human1.60316832
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60091320
36CIITA_25753668_ChIP-Seq_RAJI_Human1.58461053
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57008570
38* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.51778701
39KDM5A_27292631_Chip-Seq_BREAST_Human1.51704375
40* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51437790
41* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48842656
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45865988
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45288134
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39794133
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36331305
46ELK1_19687146_ChIP-ChIP_HELA_Human1.34590549
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.33144281
48IGF1R_20145208_ChIP-Seq_DFB_Human1.30669913
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29858877
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29240108
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27875798
52MYC_18940864_ChIP-ChIP_HL60_Human1.27674041
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.27613537
54* VDR_23849224_ChIP-Seq_CD4+_Human1.26957260
55* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26811263
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26635054
57* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24721478
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24093703
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23944228
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23508470
61TFEB_21752829_ChIP-Seq_HELA_Human1.23486389
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.23083520
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22435159
64NANOG_21062744_ChIP-ChIP_HESCs_Human1.20307354
65CHD1_26751641_Chip-Seq_LNCaP_Human1.17206475
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17145780
67FOXP3_21729870_ChIP-Seq_TREG_Human1.16887958
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16653917
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.16620030
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16247505
71TTF2_22483619_ChIP-Seq_HELA_Human1.15798491
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15786699
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14698815
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14352113
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13842124
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.13075930
77GABP_19822575_ChIP-Seq_HepG2_Human1.12885008
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11126871
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10796213
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10289106
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09240326
82TCF7_22412390_ChIP-Seq_EML_Mouse1.08068754
83* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07387626
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06770285
85PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05988214
86ETS1_20019798_ChIP-Seq_JURKAT_Human1.05367407
87FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04484444
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04292417
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04243774
90P300_19829295_ChIP-Seq_ESCs_Human1.02981528
91POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01447375
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01281005
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00962800
94DCP1A_22483619_ChIP-Seq_HELA_Human1.00846421
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00485447
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00395319
97VDR_21846776_ChIP-Seq_THP-1_Human0.99379758
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98810801
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98628307
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96981852
101ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95812798
102HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94773422
103FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94472393
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.92963403
105HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92459596
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.91556957
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91530233
108E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90957400
109NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90875223
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90626084
111SRF_21415370_ChIP-Seq_HL-1_Mouse0.89450760
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88168326
113THAP11_20581084_ChIP-Seq_MESCs_Mouse0.87704011
114SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87473087
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85881820
116ELK1_22589737_ChIP-Seq_MCF10A_Human0.85394311
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85126753
118ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84540932
119VDR_22108803_ChIP-Seq_LS180_Human0.84459681
120* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84083809
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83620605
122* BRD4_25478319_ChIP-Seq_HGPS_Human0.83191789
123ER_23166858_ChIP-Seq_MCF-7_Human0.83126184
124KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82490908
125KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82490908
126KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82490908
127EZH2_27294783_Chip-Seq_NPCs_Mouse0.81651390
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81553970
129STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81252831
130GABP_17652178_ChIP-ChIP_JURKAT_Human0.80855503
131FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80573765
132KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80474301
133CBP_20019798_ChIP-Seq_JUKART_Human0.80257823
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80257823
135CLOCK_20551151_ChIP-Seq_293T_Human0.80206357
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80144687
137HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79849150
138* STAT3_23295773_ChIP-Seq_U87_Human0.78859016
139* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78575653
140MYB_26560356_Chip-Seq_TH1_Human0.78273920
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.77710148
142GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77519029
143UTX_26944678_Chip-Seq_JUKART_Human0.77397628
144ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.77305474
145KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.77019478

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.84750502
2MP0008057_abnormal_DNA_replication3.64140614
3MP0009697_abnormal_copulation3.56335259
4MP0003111_abnormal_nucleus_morphology3.48296312
5MP0008877_abnormal_DNA_methylation3.08130798
6MP0003077_abnormal_cell_cycle3.04496335
7MP0003693_abnormal_embryo_hatching2.94949729
8MP0010352_gastrointestinal_tract_polyps2.88891865
9MP0003123_paternal_imprinting2.81461439
10MP0004957_abnormal_blastocyst_morpholog2.74632026
11MP0005076_abnormal_cell_differentiation2.57946633
12MP0008007_abnormal_cellular_replicative2.37515085
13MP0001730_embryonic_growth_arrest2.36900817
14MP0000569_abnormal_digit_pigmentation2.24838485
15MP0003121_genomic_imprinting2.20603484
16MP0008058_abnormal_DNA_repair2.15463723
17MP0010307_abnormal_tumor_latency2.12095546
18MP0000350_abnormal_cell_proliferation2.09593751
19MP0003950_abnormal_plasma_membrane2.08113380
20MP0004197_abnormal_fetal_growth/weight/2.05636808
21MP0003705_abnormal_hypodermis_morpholog1.97043093
22MP0002396_abnormal_hematopoietic_system1.95263922
23MP0005380_embryogenesis_phenotype1.94938377
24MP0001672_abnormal_embryogenesis/_devel1.94938377
25MP0003984_embryonic_growth_retardation1.87773210
26MP0000537_abnormal_urethra_morphology1.87169457
27MP0002084_abnormal_developmental_patter1.85102887
28MP0002088_abnormal_embryonic_growth/wei1.84679206
29MP0001697_abnormal_embryo_size1.80541533
30MP0004808_abnormal_hematopoietic_stem1.78671340
31MP0002085_abnormal_embryonic_tissue1.75530155
32MP0010030_abnormal_orbit_morphology1.75421560
33MP0008932_abnormal_embryonic_tissue1.69694062
34MP0003890_abnormal_embryonic-extraembry1.68738839
35MP0003718_maternal_effect1.68125958
36MP0002086_abnormal_extraembryonic_tissu1.67850451
37MP0009053_abnormal_anal_canal1.66871380
38MP0001293_anophthalmia1.61569345
39MP0002080_prenatal_lethality1.50818834
40MP0003567_abnormal_fetal_cardiomyocyte1.50681925
41MP0000733_abnormal_muscle_development1.42853025
42MP0003221_abnormal_cardiomyocyte_apopto1.37199648
43MP0000647_abnormal_sebaceous_gland1.36641166
44MP0003941_abnormal_skin_development1.36447679
45MP0002210_abnormal_sex_determination1.36359671
46MP0000372_irregular_coat_pigmentation1.35986614
47MP0000428_abnormal_craniofacial_morphol1.34808686
48MP0010678_abnormal_skin_adnexa1.34587511
49MP0003937_abnormal_limbs/digits/tail_de1.33289015
50MP0009703_decreased_birth_body1.32836526
51MP0010234_abnormal_vibrissa_follicle1.31048478
52MP0003115_abnormal_respiratory_system1.26278057
53MP0009278_abnormal_bone_marrow1.24216428
54MP0002234_abnormal_pharynx_morphology1.24002815
55MP0000383_abnormal_hair_follicle1.23641651
56MP0000427_abnormal_hair_cycle1.22197705
57MP0003935_abnormal_craniofacial_develop1.21044799
58MP0009672_abnormal_birth_weight1.17984398
59MP0005623_abnormal_meninges_morphology1.14837882
60MP0006054_spinal_hemorrhage1.14721722
61MP0003786_premature_aging1.13677695
62MP0001145_abnormal_male_reproductive1.12990790
63MP0001915_intracranial_hemorrhage1.09613675
64MP0003119_abnormal_digestive_system1.09358511
65MP0000313_abnormal_cell_death1.09193768
66MP0000432_abnormal_head_morphology1.08661268
67MP0002925_abnormal_cardiovascular_devel1.08059529
68MP0003787_abnormal_imprinting1.07522784
69MP0002092_abnormal_eye_morphology1.07407650
70MP0004233_abnormal_muscle_weight1.06262429
71MP0003385_abnormal_body_wall1.05908087
72MP0001929_abnormal_gametogenesis1.04642605
73MP0002233_abnormal_nose_morphology1.02571406
74MP0000516_abnormal_urinary_system1.02307677
75MP0005367_renal/urinary_system_phenotyp1.02307677
76MP0006292_abnormal_olfactory_placode1.00217069
77MP0002697_abnormal_eye_size1.00011136
78MP0005187_abnormal_penis_morphology0.99697272
79MP0003755_abnormal_palate_morphology0.98701452
80MP0002019_abnormal_tumor_incidence0.98520520
81MP0008995_early_reproductive_senescence0.98366198
82MP0003566_abnormal_cell_adhesion0.97940331
83MP0000358_abnormal_cell_content/0.97699977
84MP0000653_abnormal_sex_gland0.95724650
85MP0000490_abnormal_crypts_of0.93118083
86MP0005397_hematopoietic_system_phenotyp0.92184427
87MP0001545_abnormal_hematopoietic_system0.92184427
88MP0002938_white_spotting0.92138353
89MP0005408_hypopigmentation0.91018185
90MP0002111_abnormal_tail_morphology0.90772056
91MP0008789_abnormal_olfactory_epithelium0.90547845
92MP0005023_abnormal_wound_healing0.89937674
93MP0001119_abnormal_female_reproductive0.89639551
94MP0002877_abnormal_melanocyte_morpholog0.89022337
95MP0003122_maternal_imprinting0.88876190
96MP0001661_extended_life_span0.88793395
97MP0002102_abnormal_ear_morphology0.88772037
98MP0001286_abnormal_eye_development0.88178598
99MP0003091_abnormal_cell_migration0.87271430
100MP0003861_abnormal_nervous_system0.86764780
101MP0005395_other_phenotype0.86337900
102MP0005248_abnormal_Harderian_gland0.86028727
103MP0000703_abnormal_thymus_morphology0.85894082
104MP0001853_heart_inflammation0.85891013
105MP0002653_abnormal_ependyma_morphology0.82905915
106MP0005621_abnormal_cell_physiology0.82733269
107MP0006035_abnormal_mitochondrial_morpho0.82091543
108MP0002282_abnormal_trachea_morphology0.81838017
109MP0003942_abnormal_urinary_system0.81339356
110MP0002177_abnormal_outer_ear0.79712736
111MP0002114_abnormal_axial_skeleton0.78619384
112MP0003943_abnormal_hepatobiliary_system0.78499338
113MP0001529_abnormal_vocalization0.78233985
114MP0000266_abnormal_heart_morphology0.77768114
115MP0000015_abnormal_ear_pigmentation0.77432936
116MP0005384_cellular_phenotype0.76418227
117MP0001879_abnormal_lymphatic_vessel0.76325023
118MP0002116_abnormal_craniofacial_bone0.75306850
119MP0002932_abnormal_joint_morphology0.74842310
120MP0002009_preneoplasia0.74306316
121MP0002109_abnormal_limb_morphology0.74141717
122MP0001346_abnormal_lacrimal_gland0.73956160
123MP0009250_abnormal_appendicular_skeleto0.73945424
124MP0000377_abnormal_hair_follicle0.73206015
125MP0002163_abnormal_gland_morphology0.72730641
126MP0002751_abnormal_autonomic_nervous0.72449091
127MP0001177_atelectasis0.72004458
128MP0000534_abnormal_ureter_morphology0.71888843
129MP0001849_ear_inflammation0.70980171
130MP0002166_altered_tumor_susceptibility0.70269838
131MP0002006_tumorigenesis0.70262420
132MP0005503_abnormal_tendon_morphology0.69233349
133MP0003699_abnormal_female_reproductive0.68017203
134MP0010630_abnormal_cardiac_muscle0.67993364
135MP0003300_gastrointestinal_ulcer0.66405872
136MP0005174_abnormal_tail_pigmentation0.66053806
137MP0003315_abnormal_perineum_morphology0.65161717
138MP0001784_abnormal_fluid_regulation0.64580581

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)4.01990280
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.01990280
3Volvulus (HP:0002580)3.93334156
4Increased nuchal translucency (HP:0010880)3.24003097
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.18921729
6Abnormality of the ileum (HP:0001549)3.11706409
7Deviation of the thumb (HP:0009603)3.00304449
8Abnormality of the preputium (HP:0100587)2.98788912
9Abnormality of the 4th metacarpal (HP:0010012)2.95859675
10Proximal placement of thumb (HP:0009623)2.89836409
11Selective tooth agenesis (HP:0001592)2.86495717
12Small intestinal stenosis (HP:0012848)2.75971801
13Duodenal stenosis (HP:0100867)2.75971801
14Ependymoma (HP:0002888)2.61545208
15Medulloblastoma (HP:0002885)2.60581725
16Long eyelashes (HP:0000527)2.60331552
17Ectopic kidney (HP:0000086)2.59110487
18Cortical dysplasia (HP:0002539)2.56569734
19Myelodysplasia (HP:0002863)2.54064316
20Astrocytoma (HP:0009592)2.52438665
21Abnormality of the astrocytes (HP:0100707)2.52438665
22Abnormality of the duodenum (HP:0002246)2.48540446
23Long clavicles (HP:0000890)2.42788782
24Abnormality of the fingertips (HP:0001211)2.41895797
25Colon cancer (HP:0003003)2.41249858
26Microvesicular hepatic steatosis (HP:0001414)2.39580578
27Hyperacusis (HP:0010780)2.38998279
28Trigonocephaly (HP:0000243)2.35208168
29Sloping forehead (HP:0000340)2.34278937
30Chromsome breakage (HP:0040012)2.30536420
31Abnormality of the labia minora (HP:0012880)2.28836968
32Renal duplication (HP:0000075)2.26170666
33Birth length less than 3rd percentile (HP:0003561)2.25214628
34Cystic hygroma (HP:0000476)2.23350947
35Intestinal atresia (HP:0011100)2.23061145
36Facial hemangioma (HP:0000329)2.20134503
37Abnormal number of incisors (HP:0011064)2.20101568
38Glioma (HP:0009733)2.18268047
39Ankle contracture (HP:0006466)2.17589496
40Absent radius (HP:0003974)2.15113969
41Shallow orbits (HP:0000586)2.13950037
42Broad palm (HP:0001169)2.13858275
43Prominent nose (HP:0000448)2.13850355
44Rhabdomyosarcoma (HP:0002859)2.13630901
45Skull defect (HP:0001362)2.11571571
46Broad thumb (HP:0011304)2.08606109
47Deep philtrum (HP:0002002)2.08413399
48Thyroid carcinoma (HP:0002890)2.08057593
49Aplasia involving forearm bones (HP:0009822)2.07301636
50Absent forearm bone (HP:0003953)2.07301636
51Curly hair (HP:0002212)2.06040656
52Syringomyelia (HP:0003396)2.05199063
53Spinal cord lesions (HP:0100561)2.05199063
54Abnormality of the anterior horn cell (HP:0006802)2.04613951
55Degeneration of anterior horn cells (HP:0002398)2.04613951
56Cutaneous melanoma (HP:0012056)2.03668155
57Clubbing of toes (HP:0100760)2.02859238
58Metaphyseal cupping (HP:0003021)2.02651263
59Patellar aplasia (HP:0006443)2.02203001
60Limited elbow extension (HP:0001377)2.00804778
61Insidious onset (HP:0003587)1.99732863
62Termporal pattern (HP:0011008)1.99732863
63Truncal obesity (HP:0001956)1.96309589
64Tubulointerstitial nephritis (HP:0001970)1.96295656
65Atresia of the external auditory canal (HP:0000413)1.96276724
66Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95508644
67Heterotopia (HP:0002282)1.95098719
68Impulsivity (HP:0100710)1.94698948
69Renovascular hypertension (HP:0100817)1.94596661
70Abnormality of chromosome segregation (HP:0002916)1.93531070
71Missing ribs (HP:0000921)1.93425768
72Neoplasm of striated muscle (HP:0009728)1.90631844
73Cutis marmorata (HP:0000965)1.90181673
74Abnormality of chromosome stability (HP:0003220)1.89067388
75Broad phalanges of the hand (HP:0009768)1.87861249
76Aplasia/Hypoplasia of the patella (HP:0006498)1.87724107
77Capillary hemangiomas (HP:0005306)1.87558956
78Supernumerary ribs (HP:0005815)1.86818556
79Microglossia (HP:0000171)1.86083931
80Freckling (HP:0001480)1.85694156
81Urethral obstruction (HP:0000796)1.85545583
82Absent frontal sinuses (HP:0002688)1.85532532
83Basal cell carcinoma (HP:0002671)1.85347877
84Neoplasm of the colon (HP:0100273)1.85292490
85Neoplasm of the oral cavity (HP:0100649)1.85101727
86Aplasia/Hypoplasia of the sternum (HP:0006714)1.84508952
87Subacute progressive viral hepatitis (HP:0006572)1.84124372
88Low anterior hairline (HP:0000294)1.82966396
89Gastrointestinal carcinoma (HP:0002672)1.82146877
90Malignant gastrointestinal tract tumors (HP:0006749)1.82146877
91Choanal atresia (HP:0000453)1.81637107
92Embryonal renal neoplasm (HP:0011794)1.81300318
93Obsessive-compulsive behavior (HP:0000722)1.81124035
94Hypoplastic labia majora (HP:0000059)1.80882129
95Sandal gap (HP:0001852)1.80694222
96Dislocated radial head (HP:0003083)1.79714109
97Narrow palate (HP:0000189)1.78966942
98Abnormality of the calcaneus (HP:0008364)1.78774119
99Broad phalanx (HP:0006009)1.75079868
100Ulnar bowing (HP:0003031)1.74702299
101Abnormality of the distal phalanx of the thumb (HP:0009617)1.74344118
102Broad finger (HP:0001500)1.73787431
103Short humerus (HP:0005792)1.73295292
104Oligodactyly (HP:0012165)1.73005384
105Neoplasm of the adrenal gland (HP:0100631)1.72300070
106Cafe-au-lait spot (HP:0000957)1.72292539
107Blepharitis (HP:0000498)1.72239454
108Abnormality of the carotid arteries (HP:0005344)1.72047487
109Overlapping toe (HP:0001845)1.71687677
110Nephroblastoma (Wilms tumor) (HP:0002667)1.71623866
111Papillary thyroid carcinoma (HP:0002895)1.71614627
112Small hand (HP:0200055)1.70764335
113High pitched voice (HP:0001620)1.70741235
114Mesomelia (HP:0003027)1.70263304
115Poikiloderma (HP:0001029)1.70096477
116Cerebral aneurysm (HP:0004944)1.70065644
117Bowel diverticulosis (HP:0005222)1.69916254
118Abnormality of the radial head (HP:0003995)1.68817075
119Abnormality of the phalanges of the hallux (HP:0010057)1.67740794
120Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.67354944
121B lymphocytopenia (HP:0010976)1.67285800
122Meckel diverticulum (HP:0002245)1.67122658
123Breast carcinoma (HP:0003002)1.67099575
124Abnormality of the lower motor neuron (HP:0002366)1.67092392
125Broad long bones (HP:0005622)1.66291844
126Biliary tract neoplasm (HP:0100574)1.66212648
127Macroorchidism (HP:0000053)1.65306049
128Triphalangeal thumb (HP:0001199)1.65273680
129Abnormality of the labia majora (HP:0012881)1.64832276
130Increased density of long bones (HP:0006392)1.64471007
131Neoplasm of the adrenal cortex (HP:0100641)1.64166361
132Low posterior hairline (HP:0002162)1.63983254
133Overriding aorta (HP:0002623)1.63660517
134Arteriovenous malformation (HP:0100026)1.63285631
135Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.63111952
136Acute myeloid leukemia (HP:0004808)1.62670353
137Abnormal lung lobation (HP:0002101)1.61864489
138Pelvic girdle muscle weakness (HP:0003749)1.61811831
139Rectal prolapse (HP:0002035)1.61611131
140Fibular aplasia (HP:0002990)1.61062336
141Aplasia/hypoplasia of the humerus (HP:0006507)1.60658169
142Entropion (HP:0000621)1.60485089
143Short thumb (HP:0009778)1.58630972
144Abnormality of pyrimidine metabolism (HP:0004353)1.58203601
145Anal stenosis (HP:0002025)1.57521494
146Squamous cell carcinoma (HP:0002860)1.56538731
147Neoplasm of the small intestine (HP:0100833)1.54892683
148Abnormality of the pons (HP:0007361)1.54182413
149Postnatal growth retardation (HP:0008897)1.51638540
150Ovarian neoplasm (HP:0100615)1.51275949
151Duplicated collecting system (HP:0000081)1.50668476
152Radioulnar synostosis (HP:0002974)1.49408906
153Hypoplasia of the pons (HP:0012110)1.49406560
154Oligodactyly (hands) (HP:0001180)1.49019210
155Abnormal hair whorl (HP:0010721)1.47424472
156Abnormality of methionine metabolism (HP:0010901)1.47116310
157Astigmatism (HP:0000483)1.47014042
158Bifid tongue (HP:0010297)1.46249816
159Gaze-evoked nystagmus (HP:0000640)1.44971270
160Central scotoma (HP:0000603)1.41765862

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.92464167
2CDK124.48411978
3TRIM282.92680504
4NEK22.79471481
5WEE12.68039086
6MST42.58723825
7PBK2.56384711
8TAF12.51630737
9BCR2.33571940
10LATS12.24161862
11BRD42.24054947
12MAP3K102.09731660
13MST1R2.06024712
14EEF2K2.03447204
15PKN22.01803306
16STK31.89274082
17ATR1.78466861
18TTK1.77637420
19TRIB31.74837624
20MKNK11.72207533
21CDK41.63173394
22PLK31.62635642
23MAP3K91.59501521
24SIK31.58003746
25PASK1.57455554
26PLK11.57164122
27BUB11.57154327
28SRPK11.55054723
29SCYL21.54835969
30BRSK21.53904289
31ACVR1B1.53639021
32CHEK11.52604950
33CDK61.50920960
34EIF2AK11.43632014
35MTOR1.41370265
36CDK71.39126169
37ICK1.37398849
38STK101.36076251
39CHEK21.35568460
40AURKB1.32631366
41FRK1.31206843
42TNIK1.31152711
43MKNK21.30228213
44NEK11.29894878
45MET1.26549068
46ALK1.24730471
47ATM1.22579325
48TGFBR11.22408041
49MAP4K21.18698943
50TTN1.13911365
51PDGFRA1.13641363
52STK391.12207496
53MELK1.10698568
54RPS6KA41.10275776
55CASK1.10093479
56CDK21.08904071
57TSSK61.08726873
58FGFR11.07836646
59WNK31.07751855
60EIF2AK21.07425885
61PNCK1.07236923
62STK38L1.05221846
63RPS6KB21.04760434
64PAK41.04675554
65MAP3K41.01748399
66BMPR1B1.01132327
67STK40.97498370
68ZAK0.96094714
69ERBB40.93442934
70MAP3K80.93316227
71CDK90.93238779
72LATS20.91830435
73PLK20.90555870
74DDR20.90262595
75* CDK10.87942109
76CAMK1D0.87392140
77BMX0.85605622
78CAMK1G0.85552360
79KSR10.85432600
80BRSK10.83399110
81YES10.80989248
82BMPR20.80732457
83PTK60.80007042
84DYRK30.77760917
85PLK40.77744871
86NEK90.77252555
87PDK30.76863234
88PDK40.76863234
89MAP3K120.75519614
90PDGFRB0.75110217
91NUAK10.75067318
92LRRK20.73098066
93PIM10.71362257
94TYRO30.71282707
95PAK20.70465902
96CSNK1G10.63417755
97CSNK1D0.63114424
98CDK30.57867760
99DMPK0.57011264
100FGFR20.56833264
101CSNK1E0.56239133
102CCNB10.56078917
103PRKDC0.55177036
104* MAPK140.53552838
105RIPK10.52110766
106TEC0.51483237
107STK240.50278669
108FGFR30.49383880
109EIF2AK30.48574750
110EPHA20.47817893
111AKT20.47314590
112RPS6KB10.47142608
113* GSK3B0.46404862
114TESK10.46073091
115CSNK1A1L0.44069060
116MAPK10.43659580
117CDK80.42523347
118MARK30.42005650
119RAF10.41743874
120CLK10.41054193
121AURKA0.39073751
122ERBB30.38649110
123MAPK100.38177262
124MAP2K70.37895822
125* CSNK2A20.35849144
126MAPK80.35405166
127AKT10.35277523
128CSNK1G30.35191507
129PIK3CG0.33854475
130VRK10.33295644
131AKT30.33170688
132EGFR0.30793544
133MINK10.28977224
134CSNK2A10.28449450
135CSNK1G20.26928402
136MUSK0.26777645
137STK160.26312774

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.26109945
2Cell cycle_Homo sapiens_hsa041103.15860366
3RNA transport_Homo sapiens_hsa030132.98698481
4Mismatch repair_Homo sapiens_hsa034302.91271010
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84683317
6Protein export_Homo sapiens_hsa030602.84617320
7Proteasome_Homo sapiens_hsa030502.59952766
8Spliceosome_Homo sapiens_hsa030402.51817174
9mRNA surveillance pathway_Homo sapiens_hsa030152.46511638
10Base excision repair_Homo sapiens_hsa034102.17251415
11One carbon pool by folate_Homo sapiens_hsa006702.00925144
12Nucleotide excision repair_Homo sapiens_hsa034201.94482226
13Homologous recombination_Homo sapiens_hsa034401.90781181
14Fanconi anemia pathway_Homo sapiens_hsa034601.90533507
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87248451
16RNA degradation_Homo sapiens_hsa030181.78779698
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74407091
18p53 signaling pathway_Homo sapiens_hsa041151.74295345
19Non-homologous end-joining_Homo sapiens_hsa034501.73021185
20MicroRNAs in cancer_Homo sapiens_hsa052061.70863377
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.70635926
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52276436
23Viral carcinogenesis_Homo sapiens_hsa052031.51482159
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.48782928
25Oocyte meiosis_Homo sapiens_hsa041141.47449750
26Adherens junction_Homo sapiens_hsa045201.44139666
27Small cell lung cancer_Homo sapiens_hsa052221.42469538
28* Basal transcription factors_Homo sapiens_hsa030221.39337774
29Colorectal cancer_Homo sapiens_hsa052101.38277480
30Chronic myeloid leukemia_Homo sapiens_hsa052201.36790395
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.35853513
32Lysine degradation_Homo sapiens_hsa003101.35536093
33Hippo signaling pathway_Homo sapiens_hsa043901.34070835
34HTLV-I infection_Homo sapiens_hsa051661.30386291
35Basal cell carcinoma_Homo sapiens_hsa052171.27479331
36Propanoate metabolism_Homo sapiens_hsa006401.25527138
37Systemic lupus erythematosus_Homo sapiens_hsa053221.22558125
38Thyroid cancer_Homo sapiens_hsa052161.21660032
39mTOR signaling pathway_Homo sapiens_hsa041501.21494103
40RNA polymerase_Homo sapiens_hsa030201.20052008
41TGF-beta signaling pathway_Homo sapiens_hsa043501.18762066
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17785236
43Epstein-Barr virus infection_Homo sapiens_hsa051691.14080228
44Steroid biosynthesis_Homo sapiens_hsa001001.13648960
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11283248
46Herpes simplex infection_Homo sapiens_hsa051681.10250325
47Proteoglycans in cancer_Homo sapiens_hsa052051.09830827
48Endometrial cancer_Homo sapiens_hsa052131.06989829
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02851029
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99769974
51Non-small cell lung cancer_Homo sapiens_hsa052230.98292566
52Prostate cancer_Homo sapiens_hsa052150.97919617
53Pancreatic cancer_Homo sapiens_hsa052120.96187124
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95936695
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.95025955
56Focal adhesion_Homo sapiens_hsa045100.93291376
57Hedgehog signaling pathway_Homo sapiens_hsa043400.92981386
58Notch signaling pathway_Homo sapiens_hsa043300.90717778
59Viral myocarditis_Homo sapiens_hsa054160.90357310
60Pyruvate metabolism_Homo sapiens_hsa006200.87825825
61Pyrimidine metabolism_Homo sapiens_hsa002400.85694782
62Hepatitis B_Homo sapiens_hsa051610.83635799
63Dorso-ventral axis formation_Homo sapiens_hsa043200.82688751
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80445834
65Pathways in cancer_Homo sapiens_hsa052000.80386508
66Wnt signaling pathway_Homo sapiens_hsa043100.79780276
67Antigen processing and presentation_Homo sapiens_hsa046120.79244768
68FoxO signaling pathway_Homo sapiens_hsa040680.73986621
69Glioma_Homo sapiens_hsa052140.73366810
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72844649
71Bladder cancer_Homo sapiens_hsa052190.71915658
72Renal cell carcinoma_Homo sapiens_hsa052110.71678533
73Circadian rhythm_Homo sapiens_hsa047100.71538362
74Acute myeloid leukemia_Homo sapiens_hsa052210.70247681
75ECM-receptor interaction_Homo sapiens_hsa045120.69329540
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.69284541
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67885528
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66778828
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66551133
80B cell receptor signaling pathway_Homo sapiens_hsa046620.63464008
81Alcoholism_Homo sapiens_hsa050340.61975375
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61212494
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60277653
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60248785
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59706139
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.59334786
87Tight junction_Homo sapiens_hsa045300.59107098
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58444491
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57846725
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57615463
91Apoptosis_Homo sapiens_hsa042100.57457531
92HIF-1 signaling pathway_Homo sapiens_hsa040660.57357890
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57141523
94Shigellosis_Homo sapiens_hsa051310.56515153
95Melanoma_Homo sapiens_hsa052180.55928237
96T cell receptor signaling pathway_Homo sapiens_hsa046600.55003798
97VEGF signaling pathway_Homo sapiens_hsa043700.53754403
98Selenocompound metabolism_Homo sapiens_hsa004500.53631154
99Measles_Homo sapiens_hsa051620.50937241
100Fatty acid biosynthesis_Homo sapiens_hsa000610.49810877
101AMPK signaling pathway_Homo sapiens_hsa041520.47614508
102Platelet activation_Homo sapiens_hsa046110.46420517
103Vitamin B6 metabolism_Homo sapiens_hsa007500.46065782
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44935364
105Influenza A_Homo sapiens_hsa051640.44183001
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.44063053
107Toxoplasmosis_Homo sapiens_hsa051450.42201481
108ErbB signaling pathway_Homo sapiens_hsa040120.41145816
109Legionellosis_Homo sapiens_hsa051340.40619618
110Purine metabolism_Homo sapiens_hsa002300.39720966
111Insulin signaling pathway_Homo sapiens_hsa049100.38182995
112N-Glycan biosynthesis_Homo sapiens_hsa005100.38092289
113Glucagon signaling pathway_Homo sapiens_hsa049220.38028703
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.37594929
115Insulin resistance_Homo sapiens_hsa049310.36878133
116Estrogen signaling pathway_Homo sapiens_hsa049150.35554500
117Inositol phosphate metabolism_Homo sapiens_hsa005620.35129727
118Biosynthesis of amino acids_Homo sapiens_hsa012300.33838041
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31696395
120Sphingolipid metabolism_Homo sapiens_hsa006000.29518455
121Folate biosynthesis_Homo sapiens_hsa007900.28939986
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28605638
123Butanoate metabolism_Homo sapiens_hsa006500.25556659
124Sulfur metabolism_Homo sapiens_hsa009200.23910310
125beta-Alanine metabolism_Homo sapiens_hsa004100.23830758
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23437466
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22783224
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21535797
129Fatty acid elongation_Homo sapiens_hsa000620.19951619
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18400336
131Metabolic pathways_Homo sapiens_hsa011000.18285687
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.11976654
133Caffeine metabolism_Homo sapiens_hsa002320.11439150

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