TAF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA methylation (GO:0044030)6.94515495
2doxorubicin metabolic process (GO:0044598)6.85821448
3daunorubicin metabolic process (GO:0044597)6.85821448
4polyketide metabolic process (GO:0030638)6.85821448
5protein localization to kinetochore (GO:0034501)5.72120752
6protein localization to chromosome, centromeric region (GO:0071459)5.25871146
7mitotic sister chromatid segregation (GO:0000070)5.11348426
8regulation of nuclear cell cycle DNA replication (GO:0033262)5.03167017
9DNA replication checkpoint (GO:0000076)4.82935891
10negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.67558308
11histone H4-K12 acetylation (GO:0043983)4.62045324
12mitotic chromosome condensation (GO:0007076)4.61133893
13protein-cofactor linkage (GO:0018065)4.45367772
14centriole replication (GO:0007099)4.45320989
15mitotic metaphase plate congression (GO:0007080)4.30733608
16positive regulation of DNA-dependent DNA replication (GO:2000105)4.28615847
17negative regulation of cell cycle G2/M phase transition (GO:1902750)4.25781114
18sister chromatid segregation (GO:0000819)4.23748249
19aminoglycoside antibiotic metabolic process (GO:0030647)4.19729285
20establishment of protein localization to mitochondrial membrane (GO:0090151)4.18849977
21regulation of telomere maintenance via telomerase (GO:0032210)4.16939841
22nuclear pore complex assembly (GO:0051292)4.14534467
23somite rostral/caudal axis specification (GO:0032525)4.10206589
24DNA replication-dependent nucleosome organization (GO:0034723)4.07941172
25DNA replication-dependent nucleosome assembly (GO:0006335)4.07941172
26positive regulation of histone H3-K4 methylation (GO:0051571)4.05171871
27rRNA transcription (GO:0009303)4.04754110
28regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.04284921
29chaperone-mediated protein transport (GO:0072321)3.87635729
30mitotic sister chromatid cohesion (GO:0007064)3.83392983
31DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.78625324
32regulation of mammary gland epithelial cell proliferation (GO:0033599)3.78391274
33neurofilament cytoskeleton organization (GO:0060052)3.72802206
34notochord development (GO:0030903)3.69200084
35metaphase plate congression (GO:0051310)3.67764794
36negative regulation of translation, ncRNA-mediated (GO:0040033)3.66535059
37regulation of translation, ncRNA-mediated (GO:0045974)3.66535059
38negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.66535059
39heterochromatin organization (GO:0070828)3.64607879
40DNA damage response, signal transduction resulting in transcription (GO:0042772)3.63078088
41regulation of female gonad development (GO:2000194)3.62361365
42chromatin assembly (GO:0031497)3.60557532
43negative regulation of epidermis development (GO:0045683)3.58436039
44RNA destabilization (GO:0050779)3.56863326
45negative regulation of telomere maintenance (GO:0032205)3.53686011
46nuclear pore organization (GO:0006999)3.52822610
47kinetochore assembly (GO:0051382)3.52191363
48regulation of DNA endoreduplication (GO:0032875)3.52124620
49rRNA methylation (GO:0031167)3.51826198
50histone H4-K8 acetylation (GO:0043982)3.50505791
51histone H4-K5 acetylation (GO:0043981)3.50505791
52protein K6-linked ubiquitination (GO:0085020)3.47290575
53kinetochore organization (GO:0051383)3.47072164
54positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.42882976
55chromatin assembly or disassembly (GO:0006333)3.42681054
56regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.42553585
57regulation of mitotic spindle checkpoint (GO:1903504)3.42553585
58negative regulation of telomerase activity (GO:0051974)3.40061461
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.40053533
60multicellular organism reproduction (GO:0032504)3.36686279
61protein K11-linked deubiquitination (GO:0035871)3.36271839
62attachment of spindle microtubules to kinetochore (GO:0008608)3.36183180
63establishment of chromosome localization (GO:0051303)3.34246225
64regulation of double-strand break repair via homologous recombination (GO:0010569)3.34146884
65rRNA modification (GO:0000154)3.32230301
66histone H3-K4 methylation (GO:0051568)3.30118326
67regulation of histone H3-K4 methylation (GO:0051569)3.29465917
68chromatin remodeling at centromere (GO:0031055)3.28880422
69mitotic G2/M transition checkpoint (GO:0044818)3.27825031
70pre-miRNA processing (GO:0031054)3.25553541
71regulation of double-strand break repair (GO:2000779)3.25013886
72retinal cone cell development (GO:0046549)3.24627886
73protein localization to chromosome (GO:0034502)3.24602670
74pore complex assembly (GO:0046931)3.23710596
75pattern specification involved in kidney development (GO:0061004)3.22054946
76regulation of DNA-dependent DNA replication (GO:0090329)3.22043477
77interferon-gamma production (GO:0032609)3.20243992
78negative regulation of DNA-dependent DNA replication (GO:2000104)3.16849421
79ribosome biogenesis (GO:0042254)3.15944427
80negative regulation of epidermal cell differentiation (GO:0045605)3.15557397
81male meiosis (GO:0007140)3.15512059
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14641691
83mitochondrial respiratory chain complex I assembly (GO:0032981)3.14641691
84NADH dehydrogenase complex assembly (GO:0010257)3.14641691
85* maintenance of protein location in nucleus (GO:0051457)3.13914173
86regulation of meiosis I (GO:0060631)3.13460742
87piRNA metabolic process (GO:0034587)3.13089553
88maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12941652
89mRNA stabilization (GO:0048255)3.10255343
90RNA stabilization (GO:0043489)3.10255343
91sister chromatid cohesion (GO:0007062)3.09879595
92intestinal epithelial cell development (GO:0060576)3.04327179
93male meiosis I (GO:0007141)3.03076034
94meiotic chromosome segregation (GO:0045132)3.00618517
95histone H3-K4 trimethylation (GO:0080182)2.98606844
96chromosome segregation (GO:0007059)2.97573559
97female gamete generation (GO:0007292)2.96600078
98regulation of telomere maintenance (GO:0032204)2.96078621
99centriole assembly (GO:0098534)2.95599554
100microtubule severing (GO:0051013)2.95254502
101phenol-containing compound catabolic process (GO:0019336)2.94621559
102negative regulation of transcription regulatory region DNA binding (GO:2000678)2.93982036
103replication fork processing (GO:0031297)2.93593264
104DNA methylation involved in gamete generation (GO:0043046)2.93473073
105histone H3 acetylation (GO:0043966)2.92907276
106regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.91973606
107regulation of histone H3-K27 methylation (GO:0061085)2.91058131
108regulation of translation in response to stress (GO:0043555)2.91001142
109mitochondrial respiratory chain complex assembly (GO:0033108)2.90583743
110regulation of histone H3-K9 methylation (GO:0051570)2.90237214
111transcription from mitochondrial promoter (GO:0006390)2.89555435
112protein complex biogenesis (GO:0070271)2.89258638
113DNA alkylation (GO:0006305)2.88573612
114DNA methylation (GO:0006306)2.88573612
115histone H2A monoubiquitination (GO:0035518)2.88145152
116regulation of spindle checkpoint (GO:0090231)2.86762499
117muscle organ morphogenesis (GO:0048644)2.86423646
118viral protein processing (GO:0019082)2.86175231
119meiotic cell cycle (GO:0051321)2.85988771
120regulation of response to osmotic stress (GO:0047484)2.85948542
121regulation of MHC class I biosynthetic process (GO:0045343)2.85396378
122DNA double-strand break processing (GO:0000729)2.85343159
123double-strand break repair via homologous recombination (GO:0000724)2.84393870
124base-excision repair, AP site formation (GO:0006285)2.84369355
125behavioral response to nicotine (GO:0035095)2.83607531
126recombinational repair (GO:0000725)2.82923690
127regulation of histone methylation (GO:0031060)2.81473836
128DNA replication initiation (GO:0006270)2.80531915
129DNA methylation or demethylation (GO:0044728)2.80003732
130intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.79183930
131maturation of 5.8S rRNA (GO:0000460)2.79042586
132transcription elongation from RNA polymerase I promoter (GO:0006362)2.78889144
133DNA replication-independent nucleosome assembly (GO:0006336)2.78744253
134DNA replication-independent nucleosome organization (GO:0034724)2.78744253
135spindle checkpoint (GO:0031577)2.78693442
136histone exchange (GO:0043486)2.78619696
137negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.78332927
138tolerance induction (GO:0002507)2.78083057
139synapsis (GO:0007129)2.77965142
140regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.77773770
141DNA-dependent DNA replication (GO:0006261)2.77623179
142mitotic nuclear envelope disassembly (GO:0007077)2.77474473
143positive regulation of histone methylation (GO:0031062)2.75444624
144primitive streak formation (GO:0090009)2.75212087
145termination of RNA polymerase I transcription (GO:0006363)2.74865318
146histone H4-K16 acetylation (GO:0043984)2.74782131
147inner mitochondrial membrane organization (GO:0007007)2.72911381
148cell fate commitment involved in formation of primary germ layer (GO:0060795)2.71694453
149protein polyglutamylation (GO:0018095)2.69837837
150establishment of protein localization to Golgi (GO:0072600)2.69511711
151CENP-A containing nucleosome assembly (GO:0034080)2.68524572
152regulation of cell cycle G2/M phase transition (GO:1902749)2.67673584
153regulation of cilium movement (GO:0003352)2.66459204
154respiratory chain complex IV assembly (GO:0008535)2.66373867
155somatic hypermutation of immunoglobulin genes (GO:0016446)2.62286304
156somatic diversification of immune receptors via somatic mutation (GO:0002566)2.62286304
157centrosome organization (GO:0051297)2.61081448
158negative regulation of histone methylation (GO:0031061)2.59097452
159DNA modification (GO:0006304)2.57874788
160meiosis I (GO:0007127)2.57211542
161regulation of centriole replication (GO:0046599)2.53953440
162somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.53096488
163isotype switching (GO:0045190)2.53096488
164somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.53096488
165positive regulation of mitotic sister chromatid separation (GO:1901970)2.53048616
166positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.53048616
167positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.53048616
168sleep (GO:0030431)2.52781782
169microtubule organizing center organization (GO:0031023)2.52588199
170pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.50707068
171protein targeting to Golgi (GO:0000042)2.49555035
172exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49404364
173somatic diversification of immunoglobulins (GO:0016445)2.48944170
174DNA catabolic process, exonucleolytic (GO:0000738)2.45618494
175transcription from RNA polymerase III promoter (GO:0006383)2.43988608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.05470076
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.16405548
3EZH2_22144423_ChIP-Seq_EOC_Human6.05611759
4TP63_19390658_ChIP-ChIP_HaCaT_Human5.16927183
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.65766262
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.21777149
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.21777149
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.21777149
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.96962632
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.70156558
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.42480482
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.26130502
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14909139
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.99875703
15ZNF274_21170338_ChIP-Seq_K562_Hela2.47326883
16VDR_22108803_ChIP-Seq_LS180_Human2.37231988
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.34187834
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24137612
19ELK1_19687146_ChIP-ChIP_HELA_Human2.22488625
20IGF1R_20145208_ChIP-Seq_DFB_Human2.18118919
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.13409318
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13076998
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10980281
24TCF3_18692474_ChIP-Seq_MESCs_Mouse2.08694506
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.86922445
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.80839944
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78120786
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77366779
29AR_21909140_ChIP-Seq_LNCAP_Human1.77128943
30NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.74385727
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.73401909
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.71039747
33EWS_26573619_Chip-Seq_HEK293_Human1.69912537
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.66039181
35NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.57682541
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57190966
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56108749
38SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.55797300
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49244687
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49057226
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48887031
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48376671
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.47335936
44TCF3_18692474_ChIP-Seq_MEFs_Mouse1.46262984
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45046329
46IRF1_19129219_ChIP-ChIP_H3396_Human1.44836141
47* GABP_19822575_ChIP-Seq_HepG2_Human1.43892045
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43200070
49TP53_22573176_ChIP-Seq_HFKS_Human1.41683228
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41381680
51SCL_19346495_ChIP-Seq_HPC-7_Human1.38948225
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37175228
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35294793
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35109200
55NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.34834667
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.32815036
57RNF2_27304074_Chip-Seq_NSC_Mouse1.31437131
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30056899
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29992399
60GBX2_23144817_ChIP-Seq_PC3_Human1.29409872
61* CBP_20019798_ChIP-Seq_JUKART_Human1.26304747
62* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26304747
63TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.25577226
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24172581
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.24157046
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24097902
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.21889766
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19451234
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19262827
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18915698
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.17803355
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15962644
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14117566
74* FOXP3_21729870_ChIP-Seq_TREG_Human1.13646430
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13435688
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12964239
77MYC_22102868_ChIP-Seq_BL_Human1.10495622
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09389957
79PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.08782880
80MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08378049
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07406587
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05663033
83BCAT_22108803_ChIP-Seq_LS180_Human1.05514383
84ELK1_22589737_ChIP-Seq_MCF10A_Human1.03801716
85EST1_17652178_ChIP-ChIP_JURKAT_Human1.03746559
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01723611
87ER_23166858_ChIP-Seq_MCF-7_Human1.00889951
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00301626
89NANOG_18692474_ChIP-Seq_MESCs_Mouse0.98179191
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97337039
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97337039
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97027289
93GATA3_26560356_Chip-Seq_TH1_Human0.96620660
94KDM5A_27292631_Chip-Seq_BREAST_Human0.95899606
95* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.95710232
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94918429
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94651465
98STAT3_18555785_ChIP-Seq_MESCs_Mouse0.94489747
99NANOG_20526341_ChIP-Seq_ESCs_Human0.94485136
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93761944
101* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93591059
102GATA3_21878914_ChIP-Seq_MCF-7_Human0.93584891
103CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93050211
104MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92571391
105AR_25329375_ChIP-Seq_VCAP_Human0.91704583
106PRDM14_20953172_ChIP-Seq_ESCs_Human0.91608131
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91328274
108TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91315128
109POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.91150791
110POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90835269
111P300_19829295_ChIP-Seq_ESCs_Human0.90358330
112* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90308974
113* FOXA1_25329375_ChIP-Seq_VCAP_Human0.90308974
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89754390
115FLI1_21867929_ChIP-Seq_TH2_Mouse0.89398520
116MYC_18940864_ChIP-ChIP_HL60_Human0.88992012
117KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88919997
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88486182
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88383168
120NANOG_21062744_ChIP-ChIP_HESCs_Human0.88363398
121CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88138006
122TTF2_22483619_ChIP-Seq_HELA_Human0.87841251
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87820965
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87443600
125HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86604573
126DCP1A_22483619_ChIP-Seq_HELA_Human0.85879968
127GATA3_26560356_Chip-Seq_TH2_Human0.85674635
128HOXB7_26014856_ChIP-Seq_BT474_Human0.85349617
129HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.85164315
130* TCF4_23295773_ChIP-Seq_U87_Human0.85029030
131* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84989867
132* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84664594
133SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84569332
134ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83705256
135VDR_23849224_ChIP-Seq_CD4+_Human0.82553072
136CREB1_15753290_ChIP-ChIP_HEK293T_Human0.82224374
137EZH2_27294783_Chip-Seq_NPCs_Mouse0.81493235
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81008038
139CIITA_25753668_ChIP-Seq_RAJI_Human0.80792131
140SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80328225
141MYB_26560356_Chip-Seq_TH1_Human0.79448239
142KAP1_27257070_Chip-Seq_ESCs_Mouse0.78116106
143MYC_18358816_ChIP-ChIP_MESCs_Mouse0.77090077
144* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76685544
145LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75474090
146SOX2_16153702_ChIP-ChIP_HESCs_Human0.74444367
147CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73313900
148E2F1_17053090_ChIP-ChIP_MCF-7_Human0.73233901
149NANOG_16153702_ChIP-ChIP_HESCs_Human0.72922091
150ZFP281_27345836_Chip-Seq_ESCs_Mouse0.72129455
151SOX2_18555785_ChIP-Seq_MESCs_Mouse0.71336789
152GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69827046
153NELFA_20434984_ChIP-Seq_ESCs_Mouse0.69740628
154NFE2_27457419_Chip-Seq_LIVER_Mouse0.69626601
155ZFX_18555785_Chip-Seq_ESCs_Mouse0.68133083
156TBX3_20139965_ChIP-Seq_ESCs_Mouse0.66819432
157BMI1_23680149_ChIP-Seq_NPCS_Mouse0.66233579
158POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.66047691
159ELK4_26923725_Chip-Seq_MESODERM_Mouse0.65927948
160HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.65660956
161SOX2_18692474_ChIP-Seq_MESCs_Mouse0.65153731

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.84805222
2MP0005257_abnormal_intraocular_pressure3.87393236
3MP0008057_abnormal_DNA_replication3.43602338
4MP0008995_early_reproductive_senescence3.29769622
5MP0003693_abnormal_embryo_hatching3.07570261
6MP0003111_abnormal_nucleus_morphology2.88814959
7MP0003787_abnormal_imprinting2.78728426
8MP0004957_abnormal_blastocyst_morpholog2.77219543
9MP0010094_abnormal_chromosome_stability2.74176609
10MP0003077_abnormal_cell_cycle2.72461769
11MP0003121_genomic_imprinting2.70235301
12MP0004264_abnormal_extraembryonic_tissu2.62888394
13MP0001986_abnormal_taste_sensitivity2.60794383
14MP0003890_abnormal_embryonic-extraembry2.52757450
15MP0002396_abnormal_hematopoietic_system2.32055726
16MP0000566_synostosis2.30807081
17MP0002277_abnormal_respiratory_mucosa2.20976272
18MP0008877_abnormal_DNA_methylation2.13295650
19MP0008007_abnormal_cellular_replicative2.08049823
20MP0008058_abnormal_DNA_repair2.03792289
21MP0005394_taste/olfaction_phenotype1.96046575
22MP0005499_abnormal_olfactory_system1.96046575
23MP0003011_delayed_dark_adaptation1.95641509
24MP0005075_abnormal_melanosome_morpholog1.90426285
25MP0003123_paternal_imprinting1.85416740
26MP0001849_ear_inflammation1.78897574
27MP0002163_abnormal_gland_morphology1.78585793
28MP0004142_abnormal_muscle_tone1.74524327
29MP0005380_embryogenesis_phenotype1.73393016
30MP0001672_abnormal_embryogenesis/_devel1.73393016
31MP0000350_abnormal_cell_proliferation1.71057828
32MP0002160_abnormal_reproductive_system1.64324737
33MP0003718_maternal_effect1.61880088
34MP0005389_reproductive_system_phenotype1.58757289
35MP0000015_abnormal_ear_pigmentation1.56881810
36MP0003937_abnormal_limbs/digits/tail_de1.56497396
37MP0003984_embryonic_growth_retardation1.55764513
38MP0009046_muscle_twitch1.54778443
39MP0006276_abnormal_autonomic_nervous1.54546443
40MP0003938_abnormal_ear_development1.53790691
41MP0002088_abnormal_embryonic_growth/wei1.52050519
42MP0002653_abnormal_ependyma_morphology1.49340471
43MP0006072_abnormal_retinal_apoptosis1.47324614
44MP0003122_maternal_imprinting1.44044229
45MP0002085_abnormal_embryonic_tissue1.42561932
46MP0001968_abnormal_touch/_nociception1.41072168
47MP0003315_abnormal_perineum_morphology1.40781315
48MP0003755_abnormal_palate_morphology1.38588583
49MP0001919_abnormal_reproductive_system1.37893443
50MP0005646_abnormal_pituitary_gland1.37672441
51MP0008932_abnormal_embryonic_tissue1.36610266
52MP0002084_abnormal_developmental_patter1.34137046
53MP0005310_abnormal_salivary_gland1.34004180
54MP0000490_abnormal_crypts_of1.33590711
55MP0000569_abnormal_digit_pigmentation1.31006588
56MP0005451_abnormal_body_composition1.30929600
57MP0000678_abnormal_parathyroid_gland1.30522939
58MP0006036_abnormal_mitochondrial_physio1.30210578
59MP0002102_abnormal_ear_morphology1.29353344
60MP0000432_abnormal_head_morphology1.27430891
61MP0003646_muscle_fatigue1.25706965
62MP0005551_abnormal_eye_electrophysiolog1.24427854
63MP0002876_abnormal_thyroid_physiology1.24304220
64MP0002272_abnormal_nervous_system1.24132104
65MP0002234_abnormal_pharynx_morphology1.23700936
66MP0002254_reproductive_system_inflammat1.22003071
67MP0000049_abnormal_middle_ear1.21164858
68MP0001730_embryonic_growth_arrest1.20074691
69MP0002233_abnormal_nose_morphology1.19190885
70MP0002249_abnormal_larynx_morphology1.18113274
71MP0002210_abnormal_sex_determination1.17153538
72MP0005174_abnormal_tail_pigmentation1.15548782
73MP0003698_abnormal_male_reproductive1.13122205
74MP0005395_other_phenotype1.13038721
75MP0001119_abnormal_female_reproductive1.12809577
76MP0002932_abnormal_joint_morphology1.12475605
77MP0003786_premature_aging1.12393889
78MP0004885_abnormal_endolymph1.10906926
79MP0008789_abnormal_olfactory_epithelium1.09366345
80MP0001697_abnormal_embryo_size1.09121984
81MP0000313_abnormal_cell_death1.09075476
82MP0005671_abnormal_response_to1.08806172
83MP0003935_abnormal_craniofacial_develop1.08677172
84MP0009250_abnormal_appendicular_skeleto1.08026275
85MP0002086_abnormal_extraembryonic_tissu1.06668803
86MP0000427_abnormal_hair_cycle1.06624056
87MP0002095_abnormal_skin_pigmentation1.06614743
88MP0004924_abnormal_behavior1.06376268
89MP0005386_behavior/neurological_phenoty1.06376268
90MP0009745_abnormal_behavioral_response1.05065261
91MP0002736_abnormal_nociception_after1.04458806
92MP0000428_abnormal_craniofacial_morphol1.04410938
93MP0002114_abnormal_axial_skeleton1.04000649
94MP0005248_abnormal_Harderian_gland1.03644122
95MP0001293_anophthalmia1.02611874
96MP0002116_abnormal_craniofacial_bone1.02499521
97MP0010030_abnormal_orbit_morphology1.02047286
98MP0005410_abnormal_fertilization1.01946248
99MP0001929_abnormal_gametogenesis1.01815301
100MP0005187_abnormal_penis_morphology1.01502400
101MP0001346_abnormal_lacrimal_gland1.01217932
102MP0001529_abnormal_vocalization0.99735537
103MP0002928_abnormal_bile_duct0.99333709
104MP0001145_abnormal_male_reproductive0.98920221
105MP0002138_abnormal_hepatobiliary_system0.98612149
106MP0000631_abnormal_neuroendocrine_gland0.97976665
107MP0003136_yellow_coat_color0.95732082
108MP0005084_abnormal_gallbladder_morpholo0.95708077
109MP0001286_abnormal_eye_development0.94710343
110MP0000653_abnormal_sex_gland0.94186910
111MP0004381_abnormal_hair_follicle0.92661782
112MP0003699_abnormal_female_reproductive0.92519698
113MP0010352_gastrointestinal_tract_polyps0.92363741
114MP0001984_abnormal_olfaction0.92018907
115MP0001486_abnormal_startle_reflex0.91106044
116MP0003763_abnormal_thymus_physiology0.89516758
117MP0001324_abnormal_eye_pigmentation0.88990281
118MP0003880_abnormal_central_pattern0.88657285
119MP0002161_abnormal_fertility/fecundity0.88331696
120MP0004742_abnormal_vestibular_system0.88089143
121MP0002019_abnormal_tumor_incidence0.87881312
122MP0005379_endocrine/exocrine_gland_phen0.87262058
123MP0002127_abnormal_cardiovascular_syste0.85511498
124MP0002332_abnormal_exercise_endurance0.85218109
125MP0006035_abnormal_mitochondrial_morpho0.84333194
126MP0001853_heart_inflammation0.82957077
127MP0005197_abnormal_uvea_morphology0.82460550
128MP0002132_abnormal_respiratory_system0.80503521
129MP0001501_abnormal_sleep_pattern0.79841733
130MP0004185_abnormal_adipocyte_glucose0.79732075
131MP0001905_abnormal_dopamine_level0.78882946
132MP0002938_white_spotting0.78653825
133MP0002092_abnormal_eye_morphology0.77753902
134MP0005253_abnormal_eye_physiology0.77183904
135MP0005645_abnormal_hypothalamus_physiol0.76673775
136MP0002735_abnormal_chemical_nociception0.76630079
137MP0002557_abnormal_social/conspecific_i0.76266388
138MP0008961_abnormal_basal_metabolism0.75414089
139MP0002109_abnormal_limb_morphology0.75155170
140MP0000613_abnormal_salivary_gland0.74892600
141MP0002080_prenatal_lethality0.74117572
142MP0003186_abnormal_redox_activity0.70605318
143MP0001502_abnormal_circadian_rhythm0.70099715
144MP0002925_abnormal_cardiovascular_devel0.70025171
145MP0008872_abnormal_physiological_respon0.69836692
146MP0003195_calcinosis0.67575240
147MP0004808_abnormal_hematopoietic_stem0.66945128
148MP0003656_abnormal_erythrocyte_physiolo0.65836763
149MP0000703_abnormal_thymus_morphology0.65576852
150MP0000689_abnormal_spleen_morphology0.65344118
151MP0002398_abnormal_bone_marrow0.64973185
152MP0000716_abnormal_immune_system0.64670441
153MP0002064_seizures0.64241841
154MP0004134_abnormal_chest_morphology0.64205307
155MP0002572_abnormal_emotion/affect_behav0.63714279
156MP0000858_altered_metastatic_potential0.63594817
157MP0001188_hyperpigmentation0.63407330
158MP0000762_abnormal_tongue_morphology0.63183938
159MP0001944_abnormal_pancreas_morphology0.63113458
160MP0005508_abnormal_skeleton_morphology0.63059461
161MP0003861_abnormal_nervous_system0.62889471
162MP0001800_abnormal_humoral_immune0.62560780
163MP0000383_abnormal_hair_follicle0.60886541
164MP0003828_pulmonary_edema0.59332890
165MP0002722_abnormal_immune_system0.57576754

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.17136909
2Chromsome breakage (HP:0040012)5.99415909
3Bilateral microphthalmos (HP:0007633)4.07386634
4Oligodactyly (hands) (HP:0001180)4.01302715
5Hypochromic microcytic anemia (HP:0004840)3.89850764
6Rib fusion (HP:0000902)3.82984371
7Duplicated collecting system (HP:0000081)3.67355515
8Abnormality of the renal collecting system (HP:0004742)3.64427586
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.61346320
10Meckel diverticulum (HP:0002245)3.59878707
11Nephroblastoma (Wilms tumor) (HP:0002667)3.58421417
12Impulsivity (HP:0100710)3.43944784
13Abnormality of DNA repair (HP:0003254)3.40302093
14Abnormality of the ileum (HP:0001549)3.35071374
15Abnormality of the preputium (HP:0100587)3.34227954
16Embryonal renal neoplasm (HP:0011794)3.29780844
17Abnormality of B cell number (HP:0010975)3.29201348
18Abnormality of the phalanges of the hallux (HP:0010057)3.25279087
19Shawl scrotum (HP:0000049)3.15744591
20Pendular nystagmus (HP:0012043)3.14480811
21Abnormality of chromosome stability (HP:0003220)3.09171564
22Reticulocytopenia (HP:0001896)3.04769192
23Absent thumb (HP:0009777)3.00761627
24Renal cortical cysts (HP:0000803)2.95348366
25Rhabdomyosarcoma (HP:0002859)2.88572094
26Ectopic kidney (HP:0000086)2.87835022
27Aplasia/Hypoplasia of the fovea (HP:0008060)2.86989415
28Hypoplasia of the fovea (HP:0007750)2.86989415
29Patellar aplasia (HP:0006443)2.86269065
30Ependymoma (HP:0002888)2.85195979
31Volvulus (HP:0002580)2.80389302
32Abnormal lung lobation (HP:0002101)2.77390326
33Small intestinal stenosis (HP:0012848)2.75693041
34Duodenal stenosis (HP:0100867)2.75693041
35Abnormality of the intervertebral disk (HP:0005108)2.74973052
36Increased hepatocellular lipid droplets (HP:0006565)2.71954409
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.68274501
38Intestinal fistula (HP:0100819)2.68239958
39Hepatoblastoma (HP:0002884)2.67943701
40Anomalous pulmonary venous return (HP:0010772)2.65766489
41Horseshoe kidney (HP:0000085)2.65707599
42Oligodactyly (HP:0012165)2.64960557
43Short tibia (HP:0005736)2.62486690
44Neoplasm of striated muscle (HP:0009728)2.62272987
45Mitochondrial inheritance (HP:0001427)2.58967990
46Aplasia/Hypoplasia of the patella (HP:0006498)2.57471115
47Lip pit (HP:0100267)2.57084388
48Medulloblastoma (HP:0002885)2.55481085
49Supernumerary spleens (HP:0009799)2.54216507
50Breast hypoplasia (HP:0003187)2.51246549
51B lymphocytopenia (HP:0010976)2.50919146
52Sloping forehead (HP:0000340)2.49976533
53Increased CSF lactate (HP:0002490)2.49728602
54Lipid accumulation in hepatocytes (HP:0006561)2.49563669
55Myelodysplasia (HP:0002863)2.48812836
56Clubbing of toes (HP:0100760)2.46039008
57Aplastic anemia (HP:0001915)2.41449321
58Median cleft lip (HP:0000161)2.40015508
59Abnormality of the fovea (HP:0000493)2.38783620
60Papillary thyroid carcinoma (HP:0002895)2.38248315
61Abnormality of the renal cortex (HP:0011035)2.37831328
62Birth length less than 3rd percentile (HP:0003561)2.37489372
63Stomach cancer (HP:0012126)2.36386290
64Pancreatic fibrosis (HP:0100732)2.35814386
65Rectal fistula (HP:0100590)2.35402536
66Rectovaginal fistula (HP:0000143)2.35402536
67Pancytopenia (HP:0001876)2.32260766
68Hepatocellular necrosis (HP:0001404)2.30982010
69Abnormality of chromosome segregation (HP:0002916)2.30526094
70Abnormality of the labia minora (HP:0012880)2.28517098
71Abnormality of the duodenum (HP:0002246)2.27559260
72Abnormality of the distal phalanx of the thumb (HP:0009617)2.26980043
73Abnormality of the pulmonary veins (HP:0011718)2.25499809
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24635949
75Abnormality of alanine metabolism (HP:0010916)2.24635949
76Hyperalaninemia (HP:0003348)2.24635949
77IgG deficiency (HP:0004315)2.23971806
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23759074
79Acute necrotizing encephalopathy (HP:0006965)2.22462382
80Flat capital femoral epiphysis (HP:0003370)2.21672172
81Multiple enchondromatosis (HP:0005701)2.21195288
82Medial flaring of the eyebrow (HP:0010747)2.21081749
83Abnormality of the fingertips (HP:0001211)2.20747870
84Protruding tongue (HP:0010808)2.20126898
85Neutropenia (HP:0001875)2.19948742
86Hypergonadotropic hypogonadism (HP:0000815)2.19906009
87Thyroid-stimulating hormone excess (HP:0002925)2.18171612
88Periauricular skin pits (HP:0100277)2.17323894
89Preauricular pit (HP:0004467)2.17323894
90Short thumb (HP:0009778)2.16841688
91Oral leukoplakia (HP:0002745)2.15332743
92Bifid tongue (HP:0010297)2.14834865
93Adrenal hypoplasia (HP:0000835)2.13813402
94Pancreatic cysts (HP:0001737)2.12850830
95Nephronophthisis (HP:0000090)2.12262270
96Abnormality of the carotid arteries (HP:0005344)2.11956954
97Methylmalonic acidemia (HP:0002912)2.11297303
98Nasolacrimal duct obstruction (HP:0000579)2.10164601
99Triphalangeal thumb (HP:0001199)2.08875108
100Hepatic necrosis (HP:0002605)2.08192664
101Aplasia/Hypoplasia of the sternum (HP:0006714)2.05153089
102Abnormal mitochondria in muscle tissue (HP:0008316)2.04935865
103Bone marrow hypocellularity (HP:0005528)2.02009867
104Capillary hemangiomas (HP:0005306)2.01190383
105Astrocytoma (HP:0009592)2.00587807
106Abnormality of the astrocytes (HP:0100707)2.00587807
107Premature ovarian failure (HP:0008209)2.00104125
108Septo-optic dysplasia (HP:0100842)1.99520832
109Severe visual impairment (HP:0001141)1.98588280
110Renal Fanconi syndrome (HP:0001994)1.96297529
111Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96243135
112Prostate neoplasm (HP:0100787)1.95294752
113Aplasia/hypoplasia of the humerus (HP:0006507)1.94696881
114Prominent nose (HP:0000448)1.94287883
115Embryonal neoplasm (HP:0002898)1.94141698
116Neoplasm of the oral cavity (HP:0100649)1.93392306
117Supernumerary ribs (HP:0005815)1.93344053
118Facial hemangioma (HP:0000329)1.92134545
119Supernumerary bones of the axial skeleton (HP:0009144)1.91588049
120Skin pits (HP:0100276)1.90656515
121Progressive macrocephaly (HP:0004481)1.90152305
122Ureteral duplication (HP:0000073)1.89841330
123Severe combined immunodeficiency (HP:0004430)1.88293057
124Short humerus (HP:0005792)1.84261902
125IgM deficiency (HP:0002850)1.83713764
126Combined immunodeficiency (HP:0005387)1.83617089
127Short middle phalanx of the 5th finger (HP:0004220)1.81791870
128Tracheoesophageal fistula (HP:0002575)1.81631436
129Molar tooth sign on MRI (HP:0002419)1.81428284
130Abnormality of midbrain morphology (HP:0002418)1.81428284
131Abnormality of the renal medulla (HP:0100957)1.81017695
132Horizontal nystagmus (HP:0000666)1.80705104
133Vaginal fistula (HP:0004320)1.80322495
134Duplication of thumb phalanx (HP:0009942)1.79929244
135Increased serum lactate (HP:0002151)1.79804309
136Astigmatism (HP:0000483)1.79724324
137Hypoplastic iliac wings (HP:0002866)1.78522073
138Aganglionic megacolon (HP:0002251)1.77801937
139Cheilitis (HP:0100825)1.77593398
140Increased intramyocellular lipid droplets (HP:0012240)1.77039883
141Abnormality of small intestinal villus morphology (HP:0011472)1.76396030
142Villous atrophy (HP:0011473)1.76396030
143Partial duplication of thumb phalanx (HP:0009944)1.75550600
144Aplasia/Hypoplasia of the tongue (HP:0010295)1.74118314
1453-Methylglutaconic aciduria (HP:0003535)1.73670668
146Absent radius (HP:0003974)1.73337486
147Increased circulating renin level (HP:0000848)1.73325983
148Absent septum pellucidum (HP:0001331)1.73119842
149Hypochromic anemia (HP:0001931)1.71949523
150Congenital stationary night blindness (HP:0007642)1.71891676
151Truncal obesity (HP:0001956)1.71068888
152Acute encephalopathy (HP:0006846)1.69290965
153Glioma (HP:0009733)1.69268475
154Cystic hygroma (HP:0000476)1.68604597
155Gait imbalance (HP:0002141)1.68372104
156Abnormality of eosinophils (HP:0001879)1.68204869
157Congenital primary aphakia (HP:0007707)1.68035894
158Short 5th finger (HP:0009237)1.67990015
159Abnormality of the prostate (HP:0008775)1.67679232
160Posterior subcapsular cataract (HP:0007787)1.65561087
161Atresia of the external auditory canal (HP:0000413)1.64922760
162Abnormality of pyrimidine metabolism (HP:0004353)1.64614491
163Poor coordination (HP:0002370)1.64308165
164Hyperventilation (HP:0002883)1.63540349
165Aplasia involving forearm bones (HP:0009822)1.63109247
166Absent forearm bone (HP:0003953)1.63109247
167Abnormality of the pubic bones (HP:0003172)1.61869245
168Hypoplasia of the pons (HP:0012110)1.61315853
169Reduced antithrombin III activity (HP:0001976)1.61205830
170Abnormality of the pons (HP:0007361)1.60939306
171Abnormal rod and cone electroretinograms (HP:0008323)1.60799912
172Type II lissencephaly (HP:0007260)1.60084327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.14102488
2TTK3.32312716
3CDC73.31925825
4MAP4K13.18787013
5CDK83.07069223
6GRK53.05545118
7LATS12.64462436
8TAOK32.59425055
9CHEK22.52821991
10PLK42.48781168
11ARAF2.31556618
12CDK72.29214154
13MAP3K92.16258612
14GRK62.14965795
15STK102.12469404
16STK38L2.07204527
17ADRBK22.01987563
18LATS22.01796330
19GRK11.86593667
20MST41.74769327
21MAP3K61.72429862
22PLK11.56393598
23NEK21.55787628
24PIM21.55537107
25TNIK1.54584363
26MOS1.50406852
27MARK31.50345081
28TAOK11.49221172
29CSF1R1.48566590
30SRPK11.46444270
31GRK71.44995815
32NUAK11.42396207
33STK31.33225197
34CHEK11.24952105
35TYRO31.23203051
36TGFBR21.22064742
37TSSK61.20727663
38MARK21.19800697
39PRKD21.18061168
40TLK11.14738004
41NME11.14472153
42AKT31.13791626
43MKNK21.12145711
44FRK1.11304244
45BMPR1B1.10359401
46MAPK131.09869986
47IKBKE1.08906285
48ERBB41.08351437
49VRK21.07560932
50AURKB1.06014737
51MATK1.04110008
52MAPK70.99600688
53HIPK20.99282130
54ERN10.99010560
55WNK30.98426071
56ATM0.96439830
57MUSK0.96177018
58MAPK150.95479911
59WNK10.94949426
60BUB10.94535963
61CAMK40.92728208
62MAP2K20.87122922
63PNCK0.86680249
64DMPK0.86470888
65PINK10.84558052
66CDK20.84327828
67TEC0.83995061
68CDK40.82273431
69BRSK20.81771220
70WNK40.80990288
71ATR0.76390772
72MELK0.76016672
73PRPF4B0.72833635
74STK380.69681720
75EIF2AK20.69529524
76IKBKB0.68860671
77CDK90.68361894
78BRAF0.67412758
79VRK10.65445242
80CASK0.63931723
81CSNK1G10.59891881
82BCKDK0.59652846
83CDK30.57313677
84PDK20.57008836
85PRKCQ0.56994839
86NEK60.56463909
87* CDK10.55340645
88STK160.54394143
89INSRR0.53562413
90PKN10.53038213
91WEE10.51930027
92PRKCG0.51806168
93STK40.51496457
94DYRK20.51194467
95MAP3K130.50004288
96AKT20.49990196
97BMPR20.48586903
98PRKG20.48585476
99TNK20.48496982
100NLK0.48472038
101SGK10.47648100
102* MAPK140.47636366
103CAMK10.47577601
104CHUK0.47135017
105AURKA0.47123979
106MKNK10.46266869
107PLK30.45704979
108PRKG10.43966832
109MAP2K40.43599092
110ADRBK10.42655468
111TXK0.41914755
112PRKCI0.41755241
113PIM10.40779181
114STK390.40440255
115BRSK10.39105692
116NTRK20.38911925
117ITK0.38708222
118BRD40.38399741
119SGK20.38172235
120* GSK3B0.37727884
121MAPKAPK30.37396801
122EIF2AK10.37278540
123NEK10.36778710
124DYRK30.36626932
125CSNK2A20.36421098
126MAP3K50.35418459
127ABL20.35292501
128RPS6KA40.35122485
129CSK0.34664765
130* CSNK1E0.34143385
131MAPK110.33785056
132SYK0.33034067
133MAP3K40.32877744
134PIK3CA0.32744588
135CSNK2A10.32725065
136TRIM280.32332043
137KIT0.31174646
138PAK40.30045677
139AKT10.29641985
140FGFR30.29249414
141ABL10.29068933
142* MAPK100.29037335
143SIK30.28499889
144TESK20.28209277
145MAP2K70.26733928
146ACVR1B0.26671235
147MAPKAPK20.25378901
148ZAK0.25130665
149MAPK10.24821996
150MAP3K80.24793450
151RAF10.23552611
152STK240.23542784

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.51993536
2Fanconi anemia pathway_Homo sapiens_hsa034603.03776300
3Homologous recombination_Homo sapiens_hsa034402.92729606
4Cell cycle_Homo sapiens_hsa041102.77129702
5Vitamin B6 metabolism_Homo sapiens_hsa007502.68784929
6Oxidative phosphorylation_Homo sapiens_hsa001902.62459574
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.59439038
8* Basal transcription factors_Homo sapiens_hsa030222.58101425
9RNA degradation_Homo sapiens_hsa030182.52481670
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.34576551
11Protein export_Homo sapiens_hsa030602.34570187
12DNA replication_Homo sapiens_hsa030302.26243588
13Mismatch repair_Homo sapiens_hsa034302.25932382
14RNA transport_Homo sapiens_hsa030132.24606273
15Proteasome_Homo sapiens_hsa030502.21940977
16RNA polymerase_Homo sapiens_hsa030202.19303329
17Parkinsons disease_Homo sapiens_hsa050122.18464582
18Phototransduction_Homo sapiens_hsa047441.95670184
19mRNA surveillance pathway_Homo sapiens_hsa030151.92456519
20Spliceosome_Homo sapiens_hsa030401.85208768
21Base excision repair_Homo sapiens_hsa034101.80997276
22p53 signaling pathway_Homo sapiens_hsa041151.61744267
23Non-homologous end-joining_Homo sapiens_hsa034501.61655983
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57320410
25Linoleic acid metabolism_Homo sapiens_hsa005911.52936667
26Huntingtons disease_Homo sapiens_hsa050161.52844402
27Arachidonic acid metabolism_Homo sapiens_hsa005901.49569518
28Regulation of autophagy_Homo sapiens_hsa041401.44721734
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43505481
30Nicotine addiction_Homo sapiens_hsa050331.40319688
31Nucleotide excision repair_Homo sapiens_hsa034201.40179486
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39675301
33Ovarian steroidogenesis_Homo sapiens_hsa049131.34845949
34Cardiac muscle contraction_Homo sapiens_hsa042601.33321365
35Pancreatic cancer_Homo sapiens_hsa052121.29647321
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29622116
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25148235
38Thyroid cancer_Homo sapiens_hsa052161.24507243
39MicroRNAs in cancer_Homo sapiens_hsa052061.24482395
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22431429
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19405443
42Selenocompound metabolism_Homo sapiens_hsa004501.15542378
43* Herpes simplex infection_Homo sapiens_hsa051681.12004733
44Alzheimers disease_Homo sapiens_hsa050101.09135079
45Pyrimidine metabolism_Homo sapiens_hsa002401.07023463
46Primary immunodeficiency_Homo sapiens_hsa053401.06080955
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04217858
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01996245
49Collecting duct acid secretion_Homo sapiens_hsa049661.00317779
50Morphine addiction_Homo sapiens_hsa050320.98823556
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.97024413
52Olfactory transduction_Homo sapiens_hsa047400.95455360
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.92712715
54Ether lipid metabolism_Homo sapiens_hsa005650.90268384
55Colorectal cancer_Homo sapiens_hsa052100.89588007
56Non-small cell lung cancer_Homo sapiens_hsa052230.85022301
57Choline metabolism in cancer_Homo sapiens_hsa052310.83982761
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83495025
59Notch signaling pathway_Homo sapiens_hsa043300.82361332
60mTOR signaling pathway_Homo sapiens_hsa041500.82139831
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81723199
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81052618
63Acute myeloid leukemia_Homo sapiens_hsa052210.79963857
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79572318
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79440540
66HTLV-I infection_Homo sapiens_hsa051660.77834420
67TGF-beta signaling pathway_Homo sapiens_hsa043500.77536247
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.77404481
69One carbon pool by folate_Homo sapiens_hsa006700.77040808
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.76768292
71Butanoate metabolism_Homo sapiens_hsa006500.74531453
72Wnt signaling pathway_Homo sapiens_hsa043100.74374908
73Pathways in cancer_Homo sapiens_hsa052000.73999251
74Hematopoietic cell lineage_Homo sapiens_hsa046400.73336808
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.73244643
76Folate biosynthesis_Homo sapiens_hsa007900.73099053
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72896920
78Small cell lung cancer_Homo sapiens_hsa052220.72599957
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71078508
80Oocyte meiosis_Homo sapiens_hsa041140.70683259
81Caffeine metabolism_Homo sapiens_hsa002320.69280793
82GABAergic synapse_Homo sapiens_hsa047270.68753488
83Purine metabolism_Homo sapiens_hsa002300.68668187
84Basal cell carcinoma_Homo sapiens_hsa052170.68506742
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66888636
86Prostate cancer_Homo sapiens_hsa052150.64989112
87Fatty acid elongation_Homo sapiens_hsa000620.64444742
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64239929
89Other glycan degradation_Homo sapiens_hsa005110.63941964
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62166609
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61877935
92Propanoate metabolism_Homo sapiens_hsa006400.60343560
93Hepatitis B_Homo sapiens_hsa051610.60234357
94Prolactin signaling pathway_Homo sapiens_hsa049170.60229478
95Inositol phosphate metabolism_Homo sapiens_hsa005620.59613545
96Chronic myeloid leukemia_Homo sapiens_hsa052200.58650205
97Viral carcinogenesis_Homo sapiens_hsa052030.57721795
98Adherens junction_Homo sapiens_hsa045200.57340831
99T cell receptor signaling pathway_Homo sapiens_hsa046600.57319554
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.56890574
101Ras signaling pathway_Homo sapiens_hsa040140.55993538
102Autoimmune thyroid disease_Homo sapiens_hsa053200.55795135
103Melanoma_Homo sapiens_hsa052180.54720941
104Measles_Homo sapiens_hsa051620.54380819
105Hippo signaling pathway_Homo sapiens_hsa043900.54190465
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50702452
107Apoptosis_Homo sapiens_hsa042100.50164531
108Influenza A_Homo sapiens_hsa051640.49342162
109Lysine degradation_Homo sapiens_hsa003100.49332914
110Dorso-ventral axis formation_Homo sapiens_hsa043200.49120802
111Renal cell carcinoma_Homo sapiens_hsa052110.48141777
112Endometrial cancer_Homo sapiens_hsa052130.47381841
113Serotonergic synapse_Homo sapiens_hsa047260.47242894
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46980495
115Fructose and mannose metabolism_Homo sapiens_hsa000510.46926333
116Hedgehog signaling pathway_Homo sapiens_hsa043400.46496896
117Epstein-Barr virus infection_Homo sapiens_hsa051690.46356091
118Ribosome_Homo sapiens_hsa030100.46193682
119Circadian rhythm_Homo sapiens_hsa047100.44365748
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41702652
121Rap1 signaling pathway_Homo sapiens_hsa040150.41168312
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40521921
123VEGF signaling pathway_Homo sapiens_hsa043700.40174263
124B cell receptor signaling pathway_Homo sapiens_hsa046620.40162697
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39793985
126Bladder cancer_Homo sapiens_hsa052190.38148175
127FoxO signaling pathway_Homo sapiens_hsa040680.36280139
128MAPK signaling pathway_Homo sapiens_hsa040100.35422929
129ErbB signaling pathway_Homo sapiens_hsa040120.35206155
130Taste transduction_Homo sapiens_hsa047420.34641995
131TNF signaling pathway_Homo sapiens_hsa046680.34001621
132Steroid biosynthesis_Homo sapiens_hsa001000.33992537
133Circadian entrainment_Homo sapiens_hsa047130.32851156
134Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32792439
135Metabolic pathways_Homo sapiens_hsa011000.31572695
136Calcium signaling pathway_Homo sapiens_hsa040200.31520390
137Sulfur metabolism_Homo sapiens_hsa009200.31205777
138Amphetamine addiction_Homo sapiens_hsa050310.29165430
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27377882
140Nitrogen metabolism_Homo sapiens_hsa009100.26339735
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25721902
142cAMP signaling pathway_Homo sapiens_hsa040240.24945328
143Synaptic vesicle cycle_Homo sapiens_hsa047210.23761254
144Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23223255
145Insulin secretion_Homo sapiens_hsa049110.22946613
146Dopaminergic synapse_Homo sapiens_hsa047280.20284534
147Type I diabetes mellitus_Homo sapiens_hsa049400.20107608
148Oxytocin signaling pathway_Homo sapiens_hsa049210.19483402
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.18418019
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15573545

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