TAF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.99330870
2mitotic chromosome condensation (GO:0007076)4.75461143
3pre-miRNA processing (GO:0031054)4.71787824
4nuclear pore complex assembly (GO:0051292)4.52767961
5nuclear pore organization (GO:0006999)4.48163230
6antigen processing and presentation via MHC class Ib (GO:0002475)4.46374492
7protein localization to kinetochore (GO:0034501)4.43874209
8negative regulation of histone methylation (GO:0031061)4.34254363
9mitotic metaphase plate congression (GO:0007080)4.17686564
10protein localization to chromosome, centromeric region (GO:0071459)4.15203432
11histone H3-K36 demethylation (GO:0070544)4.07283614
12regulation of sister chromatid cohesion (GO:0007063)3.90171179
13DNA topological change (GO:0006265)3.87549627
14DNA strand renaturation (GO:0000733)3.85019460
15mitotic nuclear envelope disassembly (GO:0007077)3.76393205
16negative regulation of granulocyte differentiation (GO:0030853)3.72038041
17metaphase plate congression (GO:0051310)3.69392387
18regulation of NFAT protein import into nucleus (GO:0051532)3.65170203
19mitotic sister chromatid segregation (GO:0000070)3.61250099
20regulation of chromatin binding (GO:0035561)3.58945854
21DNA unwinding involved in DNA replication (GO:0006268)3.58627326
22regulation of RNA export from nucleus (GO:0046831)3.57573470
23DNA packaging (GO:0006323)3.56882104
24sister chromatid segregation (GO:0000819)3.55396108
25nuclear envelope disassembly (GO:0051081)3.51954062
26membrane disassembly (GO:0030397)3.51954062
27cytoplasmic mRNA processing body assembly (GO:0033962)3.43855254
28pore complex assembly (GO:0046931)3.42955640
29mRNA stabilization (GO:0048255)3.42880467
30RNA stabilization (GO:0043489)3.42880467
31regulation of spindle organization (GO:0090224)3.41573512
32histone H2A monoubiquitination (GO:0035518)3.40587467
33heterochromatin organization (GO:0070828)3.40158481
34positive thymic T cell selection (GO:0045059)3.40107388
35DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.37358968
363-UTR-mediated mRNA stabilization (GO:0070935)3.36902942
37positive regulation of mitotic sister chromatid separation (GO:1901970)3.35557585
38positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.35557585
39positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.35557585
40regulation of histone H3-K9 methylation (GO:0051570)3.32250132
41kinetochore organization (GO:0051383)3.30969726
42attachment of spindle microtubules to kinetochore (GO:0008608)3.27357820
43positive regulation of chromosome segregation (GO:0051984)3.26917351
44positive regulation of protein export from nucleus (GO:0046827)3.26544839
45protein localization to chromosome (GO:0034502)3.24872070
46regulation of histone H3-K27 methylation (GO:0061085)3.23576752
47establishment of chromosome localization (GO:0051303)3.23325988
48dosage compensation (GO:0007549)3.23286905
49positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.22517949
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.22058270
51determination of adult lifespan (GO:0008340)3.19620506
52negative regulation of erythrocyte differentiation (GO:0045647)3.19541066
53regulation of mitotic spindle organization (GO:0060236)3.18792328
54negative regulation of cell killing (GO:0031342)3.18467311
55negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.18467311
56histone H3-K9 demethylation (GO:0033169)3.17527407
57protein-DNA complex disassembly (GO:0032986)3.14787652
58nucleosome disassembly (GO:0006337)3.14787652
59positive regulation of gamma-delta T cell activation (GO:0046645)3.12603105
60regulation of gamma-delta T cell differentiation (GO:0045586)3.10656150
61DNA damage response, signal transduction resulting in transcription (GO:0042772)3.06383555
62DNA duplex unwinding (GO:0032508)3.06026275
63sister chromatid cohesion (GO:0007062)3.05757521
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04534272
65DNA geometric change (GO:0032392)3.03876777
66monoubiquitinated protein deubiquitination (GO:0035520)3.00006090
67histone lysine demethylation (GO:0070076)2.99437561
68histone H3-K4 methylation (GO:0051568)2.98085137
69positive regulation by symbiont of host defense response (GO:0052509)2.96911753
70modulation by symbiont of host defense response (GO:0052031)2.96911753
71modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.96911753
72modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.96911753
73positive regulation by organism of defense response of other organism involved in symbiotic interact2.96911753
74modulation by symbiont of host immune response (GO:0052553)2.96911753
75meiotic chromosome segregation (GO:0045132)2.95660466
76regulation of hippo signaling (GO:0035330)2.95065025
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93059139
78peptidyl-lysine trimethylation (GO:0018023)2.92633463
79nuclear envelope organization (GO:0006998)2.92220117
80spliceosomal tri-snRNP complex assembly (GO:0000244)2.91544276
81activation of Rac GTPase activity (GO:0032863)2.88680606
82DNA replication checkpoint (GO:0000076)2.87582689
83gene silencing by RNA (GO:0031047)2.86970073
84antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.85474772
85cellular response to epidermal growth factor stimulus (GO:0071364)2.84822772
86embryonic camera-type eye morphogenesis (GO:0048596)2.84212700
87chromatin assembly or disassembly (GO:0006333)2.83346709
88peptidyl-lysine methylation (GO:0018022)2.83156052
89regulation of mRNA stability (GO:0043488)2.81742742
90regulation of posttranscriptional gene silencing (GO:0060147)2.81214198
91regulation of gene silencing by miRNA (GO:0060964)2.81214198
92regulation of gene silencing by RNA (GO:0060966)2.81214198
93chromatin assembly (GO:0031497)2.80780035
94regulation of mammary gland epithelial cell proliferation (GO:0033599)2.79610605
95regulation of nucleobase-containing compound transport (GO:0032239)2.79467485
96regulation of gamma-delta T cell activation (GO:0046643)2.79295321
97regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78097334
98positive regulation of histone deacetylation (GO:0031065)2.77019192
99G1 DNA damage checkpoint (GO:0044783)2.76801148
100positive regulation of Cdc42 GTPase activity (GO:0043089)2.76400973
101RNA localization (GO:0006403)2.76321832
102histone demethylation (GO:0016577)2.75920863
103response to UV-C (GO:0010225)2.75888020
104gene silencing (GO:0016458)2.75770119
105kinetochore assembly (GO:0051382)2.74885188
106embryonic eye morphogenesis (GO:0048048)2.72917387
107regulation of RNA stability (GO:0043487)2.72706133
108nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.72587676
109regulation of DNA methylation (GO:0044030)2.72531301
110chromosome condensation (GO:0030261)2.72291127
111histone mRNA catabolic process (GO:0071044)2.72268529
112TOR signaling (GO:0031929)2.72036636
113histone H4-K12 acetylation (GO:0043983)2.71648878
114negative regulation of gene expression, epigenetic (GO:0045814)2.70922049
115apoptotic process involved in morphogenesis (GO:0060561)2.70243549
116negative regulation of catenin import into nucleus (GO:0035414)2.70202569
117V(D)J recombination (GO:0033151)2.69278021
118coronary vasculature morphogenesis (GO:0060977)2.68766245
119response to epidermal growth factor (GO:0070849)2.68757904
120trophectodermal cell differentiation (GO:0001829)2.66565617
121phosphatidylinositol dephosphorylation (GO:0046856)2.66388967
122hepatocyte apoptotic process (GO:0097284)2.65767039
123positive regulation of gene expression, epigenetic (GO:0045815)2.65545170
124DNA conformation change (GO:0071103)2.65504598
125regulation of chromosome segregation (GO:0051983)2.65192290
126negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.64572931
127maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63643354
128glucocorticoid receptor signaling pathway (GO:0042921)2.62387861
129folic acid-containing compound biosynthetic process (GO:0009396)2.62279942
130thymic T cell selection (GO:0045061)2.60379784
131intracellular estrogen receptor signaling pathway (GO:0030520)2.59745195
132N-terminal protein amino acid acetylation (GO:0006474)2.59322316
133positive T cell selection (GO:0043368)2.59005753
134histone lysine methylation (GO:0034968)2.57838096
135focal adhesion assembly (GO:0048041)2.57807793
136cell-substrate adherens junction assembly (GO:0007045)2.57807793
137regulation of DNA endoreduplication (GO:0032875)2.57705722
138regulation of somitogenesis (GO:0014807)2.57034132
139DNA replication initiation (GO:0006270)2.56863532
140peptidyl-lysine dimethylation (GO:0018027)2.56682556
141negative regulation of histone modification (GO:0031057)2.56598861
142regulation of histone H3-K4 methylation (GO:0051569)2.56382451
143histone H4-K16 acetylation (GO:0043984)2.55941300
144mitotic G1 DNA damage checkpoint (GO:0031571)2.55842997
145corticosteroid receptor signaling pathway (GO:0031958)2.54144877
146embryonic process involved in female pregnancy (GO:0060136)2.53809165
147regulation of histone methylation (GO:0031060)2.52982936
148chromosome segregation (GO:0007059)2.52835851
149negative regulation of RNA splicing (GO:0033119)2.52362613
150chromatin silencing (GO:0006342)2.52013181
151regulation of translational termination (GO:0006449)2.51804399
152regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.51489386
153DNA synthesis involved in DNA repair (GO:0000731)2.51104834
154adherens junction assembly (GO:0034333)2.49891613
155regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.49360569
156positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.49013281
157spindle checkpoint (GO:0031577)2.48999072
158histone H3-K4 trimethylation (GO:0080182)2.48157068
159planar cell polarity pathway involved in neural tube closure (GO:0090179)2.46626045
160regulation of monocyte differentiation (GO:0045655)2.45683962

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.23488137
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.65038817
3MYC_22102868_ChIP-Seq_BL_Human3.67962110
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.64877676
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.19589711
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11824091
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.98516237
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.92048341
9VDR_21846776_ChIP-Seq_THP-1_Human2.29905256
10TCF7_22412390_ChIP-Seq_EML_Mouse2.21376101
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13787210
12* E2F1_21310950_ChIP-Seq_MCF-7_Human2.13240937
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08420449
14AR_21909140_ChIP-Seq_LNCAP_Human2.04157327
15MYC_18555785_ChIP-Seq_MESCs_Mouse1.99506368
16TP63_17297297_ChIP-ChIP_HaCaT_Human1.94145100
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93098102
18* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.90783821
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86507981
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85960776
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85693286
22LXR_22292898_ChIP-Seq_THP-1_Human1.83398020
23MAF_26560356_Chip-Seq_TH1_Human1.78910412
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77221586
25KDM2B_26808549_Chip-Seq_K562_Human1.75763593
26KDM2B_26808549_Chip-Seq_DND41_Human1.75180678
27* UTX_26944678_Chip-Seq_JUKART_Human1.74215287
28* CIITA_25753668_ChIP-Seq_RAJI_Human1.73838266
29SCL_19346495_ChIP-Seq_HPC-7_Human1.73678809
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73617375
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69705827
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62123561
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61625905
34MYB_26560356_Chip-Seq_TH1_Human1.58281553
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56859903
36RUNX1_27514584_Chip-Seq_MCF-7_Human1.55463041
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54671142
38MYB_26560356_Chip-Seq_TH2_Human1.52919511
39KDM5A_27292631_Chip-Seq_BREAST_Human1.48566780
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46368028
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46123071
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45488154
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43702056
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42281168
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.39206765
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.38570107
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.37688921
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36839534
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36054821
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35854066
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34568412
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34565112
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.34276326
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34013001
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33121371
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32872917
57CREB1_26743006_Chip-Seq_LNCaP_Human1.27945513
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27055387
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27038295
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25916421
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25916421
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25916421
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25485387
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.24869126
65VDR_24763502_ChIP-Seq_THP-1_Human1.24809303
66SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.24766168
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24083588
68NCOR1_26117541_ChIP-Seq_K562_Human1.23583662
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23581302
70* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23398983
71* SMC4_20622854_ChIP-Seq_HELA_Human1.23252644
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22826531
73MAF_26560356_Chip-Seq_TH2_Human1.22638342
74* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22445209
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.20811900
76NANOG_21062744_ChIP-ChIP_HESCs_Human1.19748105
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19350379
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18450879
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16744902
80P68_20966046_ChIP-Seq_HELA_Human1.16560500
81ATF3_27146783_Chip-Seq_COLON_Human1.15669015
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15068903
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13947707
84XRN2_22483619_ChIP-Seq_HELA_Human1.13151714
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.12702644
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12692098
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12622022
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10966501
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10106870
90SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09442991
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05865261
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04865098
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04809796
94* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04738043
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04735105
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04679150
97GATA6_25053715_ChIP-Seq_YYC3_Human1.03746209
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03704873
99SPI1_23547873_ChIP-Seq_NB4_Human1.02904997
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02775241
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02614120
102CHD1_26751641_Chip-Seq_LNCaP_Human1.02271835
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99139748
104NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98789416
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98059971
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96721464
107GATA1_19941827_ChIP-Seq_MEL_Mouse0.96640904
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96006172
109CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95589560
110ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94082402
111TET1_21451524_ChIP-Seq_MESCs_Mouse0.93856029
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93583534
113* RUNX_20019798_ChIP-Seq_JUKART_Human0.92597424
114SA1_27219007_Chip-Seq_ERYTHROID_Human0.92195401
115CLOCK_20551151_ChIP-Seq_293T_Human0.92058351
116ZNF263_19887448_ChIP-Seq_K562_Human0.91849841
117GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91248436
118ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91210683
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91202705
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91184445
121TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89436875
122FOXP3_21729870_ChIP-Seq_TREG_Human0.89251951
123MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88643921
124TFEB_21752829_ChIP-Seq_HELA_Human0.87976096
125P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87908471
126FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87864171
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87292186
128SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86561500
129* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85899283
130TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85056948
131VDR_23849224_ChIP-Seq_CD4+_Human0.85032547
132DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84510128
133RACK7_27058665_Chip-Seq_MCF-7_Human0.84395007
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84213614
135SPI1_23127762_ChIP-Seq_K562_Human0.83701372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.60344610
2MP0010094_abnormal_chromosome_stability3.08200981
3MP0003111_abnormal_nucleus_morphology3.07574034
4MP0003077_abnormal_cell_cycle2.99395020
5MP0002396_abnormal_hematopoietic_system2.82870091
6MP0004957_abnormal_blastocyst_morpholog2.73758460
7MP0005076_abnormal_cell_differentiation2.67173594
8MP0005377_hearing/vestibular/ear_phenot2.66988932
9MP0003878_abnormal_ear_physiology2.66988932
10MP0008057_abnormal_DNA_replication2.47772169
11MP0010352_gastrointestinal_tract_polyps2.46801222
12MP0000678_abnormal_parathyroid_gland2.27479649
13MP0010307_abnormal_tumor_latency2.21583080
14MP0010234_abnormal_vibrissa_follicle2.18788507
15MP0003705_abnormal_hypodermis_morpholog2.14720155
16MP0009278_abnormal_bone_marrow2.07131098
17MP0003763_abnormal_thymus_physiology2.05801323
18MP0000350_abnormal_cell_proliferation2.04530098
19MP0008007_abnormal_cellular_replicative1.97887050
20MP0004185_abnormal_adipocyte_glucose1.96864250
21MP0001730_embryonic_growth_arrest1.95709642
22MP0001545_abnormal_hematopoietic_system1.94454654
23MP0005397_hematopoietic_system_phenotyp1.94454654
24MP0004808_abnormal_hematopoietic_stem1.91556516
25MP0002249_abnormal_larynx_morphology1.84227065
26MP0005409_darkened_coat_color1.82725119
27MP0000490_abnormal_crypts_of1.82338929
28MP0000566_synostosis1.81143455
29MP0004233_abnormal_muscle_weight1.77844728
30MP0003300_gastrointestinal_ulcer1.74608185
31MP0001672_abnormal_embryogenesis/_devel1.74363729
32MP0005380_embryogenesis_phenotype1.74363729
33MP0004381_abnormal_hair_follicle1.69983777
34MP0002089_abnormal_postnatal_growth/wei1.68420161
35MP0001348_abnormal_lacrimal_gland1.68157803
36MP0002796_impaired_skin_barrier1.67641979
37MP0002398_abnormal_bone_marrow1.65764603
38MP0003984_embryonic_growth_retardation1.63687808
39MP0002088_abnormal_embryonic_growth/wei1.61076324
40MP0002086_abnormal_extraembryonic_tissu1.58163430
41MP0004264_abnormal_extraembryonic_tissu1.58151528
42MP0001697_abnormal_embryo_size1.56531924
43MP0003303_peritoneal_inflammation1.54191452
44MP0000703_abnormal_thymus_morphology1.50310947
45MP0002019_abnormal_tumor_incidence1.48771413
46MP0008058_abnormal_DNA_repair1.48531087
47MP0002084_abnormal_developmental_patter1.45451770
48MP0001800_abnormal_humoral_immune1.40910973
49MP0002085_abnormal_embryonic_tissue1.39312092
50MP0002166_altered_tumor_susceptibility1.35852984
51MP0002722_abnormal_immune_system1.34576318
52MP0008961_abnormal_basal_metabolism1.31538700
53MP0003567_abnormal_fetal_cardiomyocyte1.30823370
54MP0009333_abnormal_splenocyte_physiolog1.30451090
55MP0000689_abnormal_spleen_morphology1.30127452
56MP0002080_prenatal_lethality1.28259050
57MP0004197_abnormal_fetal_growth/weight/1.27853718
58MP0001873_stomach_inflammation1.27459436
59MP0002098_abnormal_vibrissa_morphology1.25974226
60MP0004510_myositis1.25032245
61MP0001849_ear_inflammation1.24942989
62MP0003890_abnormal_embryonic-extraembry1.23383272
63MP0000716_abnormal_immune_system1.18936418
64MP0003566_abnormal_cell_adhesion1.17426259
65MP0000685_abnormal_immune_system1.17391466
66MP0002405_respiratory_system_inflammati1.16123652
67MP0000313_abnormal_cell_death1.15697955
68MP0008877_abnormal_DNA_methylation1.15461891
69MP0002006_tumorigenesis1.14555672
70MP0009672_abnormal_birth_weight1.13707050
71MP0000428_abnormal_craniofacial_morphol1.13223007
72MP0002429_abnormal_blood_cell1.11616728
73MP0002420_abnormal_adaptive_immunity1.11516097
74MP0002877_abnormal_melanocyte_morpholog1.11098539
75MP0005023_abnormal_wound_healing1.10935538
76MP0001819_abnormal_immune_cell1.09706332
77MP0005501_abnormal_skin_physiology1.09662858
78MP0010155_abnormal_intestine_physiology1.09429278
79MP0000537_abnormal_urethra_morphology1.09173625
80MP0001915_intracranial_hemorrhage1.09041198
81MP0002653_abnormal_ependyma_morphology1.07977243
82MP0002452_abnormal_antigen_presenting1.07292692
83MP0010678_abnormal_skin_adnexa1.07253144
84MP0005671_abnormal_response_to1.06028675
85MP0005387_immune_system_phenotype1.05299595
86MP0001790_abnormal_immune_system1.05299595
87MP0005257_abnormal_intraocular_pressure1.04612491
88MP0002925_abnormal_cardiovascular_devel1.01310905
89MP0000733_abnormal_muscle_development0.99484532
90MP0003866_abnormal_defecation0.98178357
91MP0002723_abnormal_immune_serum0.97692942
92MP0003453_abnormal_keratinocyte_physiol0.97040664
93MP0005375_adipose_tissue_phenotype0.95782848
94MP0009703_decreased_birth_body0.95617567
95MP0000383_abnormal_hair_follicle0.95220648
96MP0003115_abnormal_respiratory_system0.94441170
97MP0005621_abnormal_cell_physiology0.90406596
98MP0002092_abnormal_eye_morphology0.89558386
99MP0000477_abnormal_intestine_morphology0.88752947
100MP0003123_paternal_imprinting0.88389936
101MP0008932_abnormal_embryonic_tissue0.88001335
102MP0003699_abnormal_female_reproductive0.87644097
103MP0006292_abnormal_olfactory_placode0.86351351
104MP0003787_abnormal_imprinting0.85351882
105MP0000858_altered_metastatic_potential0.84823812
106MP0010630_abnormal_cardiac_muscle0.84810744
107MP0001835_abnormal_antigen_presentation0.83761465
108MP0004947_skin_inflammation0.81851876
109MP0003656_abnormal_erythrocyte_physiolo0.81818017
110MP0000377_abnormal_hair_follicle0.81174669
111MP0005666_abnormal_adipose_tissue0.80459674
112MP0005410_abnormal_fertilization0.78285048
113MP0003183_abnormal_peptide_metabolism0.77752177
114MP0003718_maternal_effect0.77500521
115MP0005451_abnormal_body_composition0.77201346
116MP0003119_abnormal_digestive_system0.76528199
117MP0003121_genomic_imprinting0.76481850
118MP0000465_gastrointestinal_hemorrhage0.76073401
119MP0003221_abnormal_cardiomyocyte_apopto0.75880151
120MP0003935_abnormal_craniofacial_develop0.75530970
121MP0001851_eye_inflammation0.75502398
122MP0005310_abnormal_salivary_gland0.75359685
123MP0001346_abnormal_lacrimal_gland0.74910252
124MP0000266_abnormal_heart_morphology0.74357837
125MP0003436_decreased_susceptibility_to0.73526829
126MP0003786_premature_aging0.71199443
127MP0003942_abnormal_urinary_system0.70402986
128MP0001929_abnormal_gametogenesis0.69765457
129MP0002009_preneoplasia0.69223053
130MP0005464_abnormal_platelet_physiology0.69205905
131MP0001216_abnormal_epidermal_layer0.69177600

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.91048282
2Volvulus (HP:0002580)3.31670941
3Achilles tendon contracture (HP:0001771)2.98274411
4Flat acetabular roof (HP:0003180)2.96135102
5T lymphocytopenia (HP:0005403)2.84904526
6Thrombocytosis (HP:0001894)2.82710041
7Abnormality of the Achilles tendon (HP:0005109)2.77428207
8Ependymoma (HP:0002888)2.74324412
9Prominent nose (HP:0000448)2.74039287
10Nasal polyposis (HP:0100582)2.67604057
11Self-mutilation (HP:0000742)2.59156394
12Basal cell carcinoma (HP:0002671)2.58931021
13Medulloblastoma (HP:0002885)2.58830805
14Obstructive sleep apnea (HP:0002870)2.57425999
15Deep philtrum (HP:0002002)2.56093914
16Long eyelashes (HP:0000527)2.53304284
17Abnormality of T cell number (HP:0011839)2.51558646
18Asymmetry of the thorax (HP:0001555)2.49018446
19Chronic otitis media (HP:0000389)2.48680688
20Deep palmar crease (HP:0006191)2.47786694
21Deep venous thrombosis (HP:0002625)2.44692996
22Myelodysplasia (HP:0002863)2.41616832
23Deviation of the thumb (HP:0009603)2.40920606
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.40196482
25Acute myeloid leukemia (HP:0004808)2.37347641
26Increased nuchal translucency (HP:0010880)2.37309592
27Proximal placement of thumb (HP:0009623)2.37059443
28Chromsome breakage (HP:0040012)2.35737566
29IgM deficiency (HP:0002850)2.35672076
30Abnormality of the distal phalanx of the thumb (HP:0009617)2.35600073
31Abnormality of the columella (HP:0009929)2.33684001
32Recurrent viral infections (HP:0004429)2.33153493
33Patellar dislocation (HP:0002999)2.32779246
34Facial hemangioma (HP:0000329)2.32031466
35Birth length less than 3rd percentile (HP:0003561)2.27712508
36Subacute progressive viral hepatitis (HP:0006572)2.26264374
37Increased density of long bones (HP:0006392)2.22108303
38Pustule (HP:0200039)2.21231290
39Heterotopia (HP:0002282)2.18686504
40Broad face (HP:0000283)2.18684851
41Rhabdomyosarcoma (HP:0002859)2.17496079
42Combined immunodeficiency (HP:0005387)2.17251927
43Short 4th metacarpal (HP:0010044)2.15476143
44Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.15476143
45High pitched voice (HP:0001620)2.15274953
46Biliary tract neoplasm (HP:0100574)2.15234354
47Ectopic kidney (HP:0000086)2.14633226
48Dislocated radial head (HP:0003083)2.14340593
49Trismus (HP:0000211)2.13305808
50Cafe-au-lait spot (HP:0000957)2.12058470
51Cutis marmorata (HP:0000965)2.10732902
52Septate vagina (HP:0001153)2.10212115
53Colon cancer (HP:0003003)2.09231125
54Neoplasm of striated muscle (HP:0009728)2.08295766
55Macroorchidism (HP:0000053)2.08214731
56Broad palm (HP:0001169)2.07982210
57Urethral obstruction (HP:0000796)2.07700273
58Malignant gastrointestinal tract tumors (HP:0006749)2.07272420
59Gastrointestinal carcinoma (HP:0002672)2.07272420
60Squamous cell carcinoma (HP:0002860)2.06431892
61Patellar aplasia (HP:0006443)2.05691906
62Abnormal platelet volume (HP:0011876)2.05059590
63Abnormality of the radial head (HP:0003995)2.03878331
64Long palpebral fissure (HP:0000637)2.03520840
65Panhypogammaglobulinemia (HP:0003139)2.02876393
66Abnormality of T cells (HP:0002843)2.02215338
67Ankyloglossia (HP:0010296)2.01775708
68Hyperacusis (HP:0010780)2.00014410
69Rectal prolapse (HP:0002035)1.99834502
70Rib fusion (HP:0000902)1.99647368
71Abnormality of chromosome stability (HP:0003220)1.98548986
72Bowel incontinence (HP:0002607)1.97842850
73Recurrent fungal infections (HP:0002841)1.97533208
74Anal stenosis (HP:0002025)1.97068292
75Abnormality of the astrocytes (HP:0100707)1.96487530
76Astrocytoma (HP:0009592)1.96487530
77Polycythemia (HP:0001901)1.96254385
78Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94844588
79Ulnar bowing (HP:0003031)1.93965687
80Gastrointestinal inflammation (HP:0004386)1.93219535
81Disproportionate tall stature (HP:0001519)1.93088637
82Neoplasm of the oral cavity (HP:0100649)1.90649307
83Inflammation of the large intestine (HP:0002037)1.90624396
84Selective tooth agenesis (HP:0001592)1.88941352
85Truncal obesity (HP:0001956)1.88487598
86Abnormality of the nasal mucosa (HP:0000433)1.87916868
87Micronodular cirrhosis (HP:0001413)1.86464316
88Germ cell neoplasia (HP:0100728)1.86205178
89Poikiloderma (HP:0001029)1.85828157
90Skull defect (HP:0001362)1.85540546
91Abnormality of the aortic arch (HP:0012303)1.85474646
92Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.84287414
93Abnormality of the phalanges of the hallux (HP:0010057)1.83481254
94Aplasia/Hypoplasia of the patella (HP:0006498)1.82976761
95Increased mean platelet volume (HP:0011877)1.82818144
96Blepharitis (HP:0000498)1.82530356
97Amaurosis fugax (HP:0100576)1.82107253
98Colitis (HP:0002583)1.81810768
99Lip pit (HP:0100267)1.81173356
100Obsessive-compulsive behavior (HP:0000722)1.80118656
101Nephroblastoma (Wilms tumor) (HP:0002667)1.78906355
102Skin tags (HP:0010609)1.77812617
103Hematochezia (HP:0002573)1.77705026
104Abnormality of chromosome segregation (HP:0002916)1.77316765
105Abnormality of the nasal septum (HP:0000419)1.76741557
106Abnormal large intestine physiology (HP:0012700)1.76590674
107Depressed nasal tip (HP:0000437)1.76177723
108Acute lymphatic leukemia (HP:0006721)1.76136362
109Sandal gap (HP:0001852)1.76107805
110Abnormality of the salivary glands (HP:0010286)1.75117137
111Transitional cell carcinoma of the bladder (HP:0006740)1.75111228
112Thyroiditis (HP:0100646)1.74863412
113Supernumerary ribs (HP:0005815)1.74670215
114Arterial thrombosis (HP:0004420)1.73969164
115Midline defect of the nose (HP:0004122)1.73694198
116Glioma (HP:0009733)1.72903438
117Seborrheic dermatitis (HP:0001051)1.72831834
118Abnormality of B cell number (HP:0010975)1.71544892
119B lymphocytopenia (HP:0010976)1.71544892
120Cellulitis (HP:0100658)1.71372104
121Low anterior hairline (HP:0000294)1.71339418
122Abnormality of cochlea (HP:0000375)1.71245868
123Impulsivity (HP:0100710)1.70976614
124Embryonal neoplasm (HP:0002898)1.70337391
125Syringomyelia (HP:0003396)1.70193919
126Spinal cord lesions (HP:0100561)1.70193919
127Abnormal delayed hypersensitivity skin test (HP:0002963)1.69268179
128Papillary thyroid carcinoma (HP:0002895)1.69111562
129Severe combined immunodeficiency (HP:0004430)1.69034176
130High anterior hairline (HP:0009890)1.68790148
131Shawl scrotum (HP:0000049)1.68431356
132Leiomyosarcoma (HP:0100243)1.68042598
133Uterine leiomyosarcoma (HP:0002891)1.68042598
134Trigonocephaly (HP:0000243)1.67838920
135Abnormal vertebral ossification (HP:0100569)1.67279892
13611 pairs of ribs (HP:0000878)1.67017071
137Abnormal number of incisors (HP:0011064)1.66375795
138Atresia of the external auditory canal (HP:0000413)1.66340258
139Abnormality of the thoracic spine (HP:0100711)1.65822900
140Limited elbow extension (HP:0001377)1.65605971
141Progressive muscle weakness (HP:0003323)1.65433409
142Autoimmune thrombocytopenia (HP:0001973)1.65383597
143Overlapping toe (HP:0001845)1.65135950
144Dysmetric saccades (HP:0000641)1.64967350
145Chest pain (HP:0100749)1.64467764
146Esophageal atresia (HP:0002032)1.63416300
147Absent thumb (HP:0009777)1.63281734
148Enlarged penis (HP:0000040)1.63262171
149Carpal bone hypoplasia (HP:0001498)1.62625774
150Lymphoma (HP:0002665)1.61972762
151Prolonged bleeding time (HP:0003010)1.61683944
152Metaphyseal cupping (HP:0003021)1.61513830
153Abnormal foot bone ossification (HP:0010675)1.61416039
154Broad thumb (HP:0011304)1.61028501
155Slow saccadic eye movements (HP:0000514)1.59491338
156Oligodactyly (HP:0012165)1.59356453
157Nasolacrimal duct obstruction (HP:0000579)1.59208629
158Embryonal renal neoplasm (HP:0011794)1.58249870
159Capillary hemangiomas (HP:0005306)1.57350353
160Bilateral sensorineural hearing impairment (HP:0008619)1.56404464
161Supernumerary bones of the axial skeleton (HP:0009144)1.55974936
162Wide nose (HP:0000445)1.54841864
163Abnormality of the lacrimal duct (HP:0011481)1.53833505
164Viral hepatitis (HP:0006562)1.53665386
165Supernumerary nipples (HP:0002558)1.53648405
166Aplasia/Hypoplasia of the thymus (HP:0010515)1.52638141
167Attention deficit hyperactivity disorder (HP:0007018)1.50598984
168Hypertriglyceridemia (HP:0002155)1.48152402
169Renal cell carcinoma (HP:0005584)1.47710954
170Sparse lateral eyebrow (HP:0005338)1.47628849

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.71680981
2CDC73.48015516
3SMG13.26391999
4EEF2K2.91494220
5NEK22.75056881
6PRPF4B2.72919646
7MAP4K12.66819512
8STK102.58291605
9TRIB32.54634856
10MAP3K102.53072532
11PKN22.42243706
12LATS12.39848992
13CDK42.05382189
14FGFR41.82417637
15STK31.81588587
16TTK1.81466603
17WNK41.81029396
18BRD41.68374916
19IRAK31.61595904
20TAOK31.59051739
21CDK61.56722339
22CDK91.50267540
23STK391.43336287
24MELK1.41160772
25RPS6KA41.39883712
26WEE11.38452458
27MAP3K61.36577043
28CAMK1D1.33770056
29MAP2K31.30348393
30TAOK11.26544590
31RPS6KB21.25425404
32ALK1.24830842
33MAP3K81.24807172
34MAP3K91.24735158
35CHEK21.23926425
36PIM11.23612125
37MOS1.23148021
38DMPK1.22108165
39MAP3K131.17970681
40CDK71.16716318
41TYK21.15157762
42MTOR1.12827067
43ATR1.11507543
44CHEK11.09197301
45WNK11.08716835
46MAP3K71.07517514
47BRSK11.05526055
48ERN11.05202494
49JAK31.00974777
50AURKB0.99916740
51PLK40.99645110
52BRAF0.98937131
53GRK60.95642160
54LRRK20.93546533
55ACVR1B0.92971530
56LATS20.91947456
57PTK20.90700603
58PLK10.89743250
59STK40.88930571
60CAMK1G0.87433811
61ATM0.86155484
62PTK60.85006104
63BTK0.84778989
64IRAK40.84235488
65RIPK40.83280627
66SIK20.81700003
67CSK0.80384725
68TYRO30.76574719
69CDK20.75146500
70STK240.73783482
71ITK0.73568782
72HIPK20.73038468
73KSR20.72688595
74EPHA20.72438619
75ZAP700.71259406
76PDK10.70372896
77PRKD20.70359218
78PDPK10.69903987
79BUB10.68767370
80IRAK20.68747558
81MAP3K10.68282150
82MARK30.65926199
83CHUK0.65237659
84YES10.64490511
85RPS6KC10.64277530
86RPS6KL10.64277530
87BRSK20.63794980
88CSF1R0.62902588
89HCK0.62810979
90BMX0.61276803
91ICK0.61222127
92TAF10.60769109
93CDC42BPA0.60321377
94TTN0.59569428
95FGFR30.58452188
96MAP3K30.58207818
97MAPK110.54727699
98RPS6KA20.54339196
99MST1R0.53931223
100MAP2K20.53108736
101AURKA0.52420781
102CLK10.52284644
103MAP3K20.51834498
104MKNK20.51544672
105MAPK100.50527840
106SGK30.50328535
107TGFBR20.49952774
108DYRK30.49802787
109MET0.48843180
110RET0.48686647
111JAK10.48599796
112CDK80.48484736
113MAPKAPK20.48417175
114JAK20.48252193
115STK38L0.48005612
116PDGFRB0.47149116
117FGFR10.46760258
118SIK10.45605190
119TGFBR10.45503822
120PAK40.44828300
121MARK20.44235589
122MAP3K140.43341675
123CDK10.42773267
124NME20.42077575
125RPS6KA60.41856397
126NEK10.41623680
127CSNK1D0.40933192
128RAF10.40125981
129MAP3K50.39780497
130KSR10.39776722
131PDGFRA0.38860286
132TAOK20.38703800
133GSK3B0.38691201
134SRPK10.38197559
135NEK60.37912114
136RPS6KA10.36744773
137RIPK10.36364693
138LCK0.35660030
139PASK0.35257995

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.60916574
2DNA replication_Homo sapiens_hsa030302.51276924
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.30216300
4RNA transport_Homo sapiens_hsa030132.18574978
5Mismatch repair_Homo sapiens_hsa034302.13940252
6Spliceosome_Homo sapiens_hsa030402.04989875
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90813707
8mRNA surveillance pathway_Homo sapiens_hsa030151.84461216
9Lysine degradation_Homo sapiens_hsa003101.82009852
10Primary immunodeficiency_Homo sapiens_hsa053401.80968241
11Base excision repair_Homo sapiens_hsa034101.75354738
12RNA degradation_Homo sapiens_hsa030181.73615128
13Chronic myeloid leukemia_Homo sapiens_hsa052201.72298314
14Homologous recombination_Homo sapiens_hsa034401.72295729
15p53 signaling pathway_Homo sapiens_hsa041151.68763940
16B cell receptor signaling pathway_Homo sapiens_hsa046621.60021357
17* Herpes simplex infection_Homo sapiens_hsa051681.56725423
18Fanconi anemia pathway_Homo sapiens_hsa034601.51883363
19MicroRNAs in cancer_Homo sapiens_hsa052061.50343134
20Small cell lung cancer_Homo sapiens_hsa052221.49933675
21Pancreatic cancer_Homo sapiens_hsa052121.47763228
22Inositol phosphate metabolism_Homo sapiens_hsa005621.47173418
23Acute myeloid leukemia_Homo sapiens_hsa052211.41541887
24Non-homologous end-joining_Homo sapiens_hsa034501.40662613
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.39984388
26One carbon pool by folate_Homo sapiens_hsa006701.35619849
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.34634017
28ErbB signaling pathway_Homo sapiens_hsa040121.33596300
29Adherens junction_Homo sapiens_hsa045201.31553315
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31076600
31mTOR signaling pathway_Homo sapiens_hsa041501.29304908
32Non-small cell lung cancer_Homo sapiens_hsa052231.27598461
33HTLV-I infection_Homo sapiens_hsa051661.27458367
34Notch signaling pathway_Homo sapiens_hsa043301.26445189
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.26356224
36Insulin signaling pathway_Homo sapiens_hsa049101.26263366
37Thyroid cancer_Homo sapiens_hsa052161.23654009
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23602025
39Colorectal cancer_Homo sapiens_hsa052101.21289931
40T cell receptor signaling pathway_Homo sapiens_hsa046601.21058037
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20636013
42Antigen processing and presentation_Homo sapiens_hsa046121.19880877
43Nucleotide excision repair_Homo sapiens_hsa034201.17981807
44Measles_Homo sapiens_hsa051621.15312860
45Hepatitis B_Homo sapiens_hsa051611.11976372
46Viral carcinogenesis_Homo sapiens_hsa052031.11092403
47Leishmaniasis_Homo sapiens_hsa051401.08071937
48Epstein-Barr virus infection_Homo sapiens_hsa051691.08022565
49Osteoclast differentiation_Homo sapiens_hsa043801.07775028
50Toxoplasmosis_Homo sapiens_hsa051451.06467586
51Influenza A_Homo sapiens_hsa051641.01885795
52Viral myocarditis_Homo sapiens_hsa054161.00658498
53Dorso-ventral axis formation_Homo sapiens_hsa043200.99247020
54Endometrial cancer_Homo sapiens_hsa052130.98645318
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98305535
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98114412
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.95865220
58Prostate cancer_Homo sapiens_hsa052150.94188858
59FoxO signaling pathway_Homo sapiens_hsa040680.94162662
60Bladder cancer_Homo sapiens_hsa052190.93291448
61Selenocompound metabolism_Homo sapiens_hsa004500.93248116
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91813754
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91617710
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90959030
65Hematopoietic cell lineage_Homo sapiens_hsa046400.89092244
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88940968
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.88097360
68Oocyte meiosis_Homo sapiens_hsa041140.87710086
69VEGF signaling pathway_Homo sapiens_hsa043700.87283475
70Apoptosis_Homo sapiens_hsa042100.86570201
71Shigellosis_Homo sapiens_hsa051310.85156176
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85111865
73Pentose phosphate pathway_Homo sapiens_hsa000300.82837072
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.79223560
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.78878379
76* Basal transcription factors_Homo sapiens_hsa030220.77455128
77ABC transporters_Homo sapiens_hsa020100.76191140
78Fatty acid biosynthesis_Homo sapiens_hsa000610.75549058
79Prolactin signaling pathway_Homo sapiens_hsa049170.75532319
80Insulin resistance_Homo sapiens_hsa049310.74951141
81Estrogen signaling pathway_Homo sapiens_hsa049150.74626029
82Proteoglycans in cancer_Homo sapiens_hsa052050.74278664
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74155109
84Wnt signaling pathway_Homo sapiens_hsa043100.73246842
85Hippo signaling pathway_Homo sapiens_hsa043900.73020883
86TGF-beta signaling pathway_Homo sapiens_hsa043500.72563212
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72188707
88Pathways in cancer_Homo sapiens_hsa052000.71475646
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71035751
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69686560
91Platelet activation_Homo sapiens_hsa046110.69127727
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68432958
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67044545
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.66408285
95Sulfur relay system_Homo sapiens_hsa041220.66311398
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.66119524
97Type II diabetes mellitus_Homo sapiens_hsa049300.66058264
98Renal cell carcinoma_Homo sapiens_hsa052110.65720945
99Chemokine signaling pathway_Homo sapiens_hsa040620.64992331
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.64698110
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62398794
102RNA polymerase_Homo sapiens_hsa030200.61432777
103Prion diseases_Homo sapiens_hsa050200.61060732
104Basal cell carcinoma_Homo sapiens_hsa052170.60920673
105GnRH signaling pathway_Homo sapiens_hsa049120.60909105
106TNF signaling pathway_Homo sapiens_hsa046680.60399082
107Other glycan degradation_Homo sapiens_hsa005110.58560470
108Long-term potentiation_Homo sapiens_hsa047200.57687590
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56938894
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56932962
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.56868565
112Fructose and mannose metabolism_Homo sapiens_hsa000510.56852771
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56297504
114Melanoma_Homo sapiens_hsa052180.56096337
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55000326
116HIF-1 signaling pathway_Homo sapiens_hsa040660.52343866
117Thyroid hormone synthesis_Homo sapiens_hsa049180.51436601
118Hepatitis C_Homo sapiens_hsa051600.51289705
119Endocytosis_Homo sapiens_hsa041440.50812483
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50113433
121Choline metabolism in cancer_Homo sapiens_hsa052310.49801659
122Tight junction_Homo sapiens_hsa045300.49735464
123Pyrimidine metabolism_Homo sapiens_hsa002400.49172721
124AMPK signaling pathway_Homo sapiens_hsa041520.49095059
125Glioma_Homo sapiens_hsa052140.48551321
126MAPK signaling pathway_Homo sapiens_hsa040100.47160041
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44175048
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42273404
129Focal adhesion_Homo sapiens_hsa045100.40567300

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