TAF5L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.71536274
2folic acid-containing compound biosynthetic process (GO:0009396)4.54886027
3ribosomal small subunit assembly (GO:0000028)4.44187285
4protein localization to kinetochore (GO:0034501)4.40112858
5nuclear pore organization (GO:0006999)4.35197702
6DNA replication initiation (GO:0006270)4.32417024
7maturation of SSU-rRNA (GO:0030490)4.23815847
8nuclear pore complex assembly (GO:0051292)4.13570017
9IMP biosynthetic process (GO:0006188)4.13454493
10mitotic nuclear envelope disassembly (GO:0007077)4.13296571
11DNA strand elongation involved in DNA replication (GO:0006271)4.02433991
12regulation of nucleobase-containing compound transport (GO:0032239)3.95755187
13formation of translation preinitiation complex (GO:0001731)3.93839038
14membrane disassembly (GO:0030397)3.84734429
15nuclear envelope disassembly (GO:0051081)3.84734429
16viral transcription (GO:0019083)3.84706079
17nucleobase biosynthetic process (GO:0046112)3.84266369
18DNA strand elongation (GO:0022616)3.84073497
19histone H3-K36 demethylation (GO:0070544)3.84056448
20translational termination (GO:0006415)3.79711001
21protein localization to chromosome, centromeric region (GO:0071459)3.78648120
22DNA replication-dependent nucleosome assembly (GO:0006335)3.77686276
23DNA replication-dependent nucleosome organization (GO:0034723)3.77686276
24telomere maintenance via semi-conservative replication (GO:0032201)3.65067375
25IMP metabolic process (GO:0046040)3.64025827
26DNA replication checkpoint (GO:0000076)3.59683641
27mRNA stabilization (GO:0048255)3.59657064
28RNA stabilization (GO:0043489)3.59657064
29regulation of histone H3-K27 methylation (GO:0061085)3.59180044
30negative regulation of erythrocyte differentiation (GO:0045647)3.59017865
31DNA duplex unwinding (GO:0032508)3.53993644
32translational elongation (GO:0006414)3.53972679
33DNA geometric change (GO:0032392)3.50338934
34purine nucleobase biosynthetic process (GO:0009113)3.45395189
35ribosome biogenesis (GO:0042254)3.45257750
36translational initiation (GO:0006413)3.45229613
37cellular protein complex localization (GO:0034629)3.43704093
38regulation of NFAT protein import into nucleus (GO:0051532)3.43321103
39ribosome assembly (GO:0042255)3.42750800
403-UTR-mediated mRNA stabilization (GO:0070935)3.41960089
41nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.41768243
42regulation of chromatin binding (GO:0035561)3.38643544
43regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34818659
44ribosomal large subunit biogenesis (GO:0042273)3.31669737
45ribonucleoprotein complex biogenesis (GO:0022613)3.30076782
46protein localization to endosome (GO:0036010)3.26989467
47regulation of histone H3-K9 methylation (GO:0051570)3.25548290
48mitotic metaphase plate congression (GO:0007080)3.23013204
49regulation of translational fidelity (GO:0006450)3.22272711
50embryonic process involved in female pregnancy (GO:0060136)3.20492100
51telomere maintenance via recombination (GO:0000722)3.19672631
52heterochromatin organization (GO:0070828)3.19059115
53ribosomal small subunit biogenesis (GO:0042274)3.18414242
54negative regulation of histone methylation (GO:0031061)3.17797767
55mitotic sister chromatid cohesion (GO:0007064)3.16993803
56pre-miRNA processing (GO:0031054)3.16412101
57negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.13709010
58mitotic sister chromatid segregation (GO:0000070)3.13512708
59mitotic chromosome condensation (GO:0007076)3.10991188
60mitotic recombination (GO:0006312)3.08661499
61nuclear envelope organization (GO:0006998)3.07921215
62pore complex assembly (GO:0046931)3.05262911
63regulation of spindle organization (GO:0090224)3.04949712
64spliceosomal tri-snRNP complex assembly (GO:0000244)3.04732660
65chromatin assembly or disassembly (GO:0006333)3.03048671
66regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01190784
67dosage compensation (GO:0007549)3.01126934
68chromatin remodeling at centromere (GO:0031055)3.00964194
69SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.00162529
70DNA replication-independent nucleosome organization (GO:0034724)2.99425727
71DNA replication-independent nucleosome assembly (GO:0006336)2.99425727
72sister chromatid segregation (GO:0000819)2.98499165
73protein complex localization (GO:0031503)2.97879062
74positive regulation of chromosome segregation (GO:0051984)2.97616777
75chromatin assembly (GO:0031497)2.97431376
76negative regulation of RNA splicing (GO:0033119)2.96600247
77translesion synthesis (GO:0019985)2.95074686
78regulation of gene silencing by RNA (GO:0060966)2.94805563
79regulation of posttranscriptional gene silencing (GO:0060147)2.94805563
80regulation of gene silencing by miRNA (GO:0060964)2.94805563
81regulation of translational termination (GO:0006449)2.94402413
82CENP-A containing nucleosome assembly (GO:0034080)2.93923333
83rRNA processing (GO:0006364)2.93551519
84cellular protein complex disassembly (GO:0043624)2.91015373
85viral life cycle (GO:0019058)2.90760796
86chromosome condensation (GO:0030261)2.90374693
87regulation of mammary gland epithelial cell proliferation (GO:0033599)2.90067372
88protein targeting to ER (GO:0045047)2.89876459
89regulation of sister chromatid cohesion (GO:0007063)2.89038537
90rRNA metabolic process (GO:0016072)2.88485639
91mitotic G1 DNA damage checkpoint (GO:0031571)2.88122934
92cotranslational protein targeting to membrane (GO:0006613)2.87903606
93metaphase plate congression (GO:0051310)2.87759196
94telomere maintenance via telomere lengthening (GO:0010833)2.87319930
95DNA synthesis involved in DNA repair (GO:0000731)2.87238962
96somatic diversification of immune receptors via somatic mutation (GO:0002566)2.86373246
97somatic hypermutation of immunoglobulin genes (GO:0016446)2.86373246
98protein export from nucleus (GO:0006611)2.85897819
99DNA deamination (GO:0045006)2.85170604
100DNA conformation change (GO:0071103)2.83442551
101regulation of histone methylation (GO:0031060)2.83397138
102nuclear-transcribed mRNA catabolic process (GO:0000956)2.81168375
103regulation of helicase activity (GO:0051095)2.79189233
104regulation of RNA export from nucleus (GO:0046831)2.78773598
105histone H2B ubiquitination (GO:0033523)2.77714675
106establishment of protein localization to endoplasmic reticulum (GO:0072599)2.76790563
107protein complex disassembly (GO:0043241)2.75277518
108protein localization to chromosome (GO:0034502)2.74115107
109RNA catabolic process (GO:0006401)2.73823833
110histone H2A monoubiquitination (GO:0035518)2.73249982
111attachment of spindle microtubules to kinetochore (GO:0008608)2.72303485
112histone lysine demethylation (GO:0070076)2.70030443
113snRNA metabolic process (GO:0016073)2.69951916
114protein localization to endoplasmic reticulum (GO:0070972)2.69918990
115negative regulation of DNA repair (GO:0045738)2.69881556
116nucleotide-excision repair, DNA gap filling (GO:0006297)2.68364839
117negative regulation of mRNA processing (GO:0050686)2.68292752
118snRNA processing (GO:0016180)2.68188252
119mRNA catabolic process (GO:0006402)2.67913768
120folic acid metabolic process (GO:0046655)2.66448465
121trophectodermal cell differentiation (GO:0001829)2.65130959
122protein localization to microtubule (GO:0035372)2.64986876
123mRNA splicing, via spliceosome (GO:0000398)2.63171347
124RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.63171347
125histone demethylation (GO:0016577)2.60046748
126glucocorticoid receptor signaling pathway (GO:0042921)2.59550234
127response to muramyl dipeptide (GO:0032495)2.59203140
128histone phosphorylation (GO:0016572)2.58045677
129regulation of mitotic spindle organization (GO:0060236)2.57713595
130positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.56651636
131cell-substrate adherens junction assembly (GO:0007045)2.55970477
132focal adhesion assembly (GO:0048041)2.55970477
133DNA packaging (GO:0006323)2.54353177
134N-terminal protein amino acid acetylation (GO:0006474)2.54074617
135positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.53849167
136adherens junction assembly (GO:0034333)2.53397419
137regulation of histone H3-K4 methylation (GO:0051569)2.51879424
138regulation of early endosome to late endosome transport (GO:2000641)2.51126523
139positive regulation of gamma-delta T cell activation (GO:0046645)2.49532994
140apoptotic process involved in morphogenesis (GO:0060561)2.48614457
141positive regulation of DNA-templated transcription, initiation (GO:2000144)2.45968527
142positive regulation of DNA-dependent DNA replication (GO:2000105)2.45813895
143peptidyl-lysine dimethylation (GO:0018027)2.44713776
144response to laminar fluid shear stress (GO:0034616)2.43760299
145regulation of mRNA stability (GO:0043488)2.40451564
146regulation of RNA stability (GO:0043487)2.40340761
147activation of Rac GTPase activity (GO:0032863)2.40195637
148DNA topological change (GO:0006265)2.38751478
149histone H3-K9 demethylation (GO:0033169)2.38079359
150establishment of chromosome localization (GO:0051303)2.37536434
151regulation of DNA damage checkpoint (GO:2000001)2.34945179
152mRNA transport (GO:0051028)2.32388389
153negative regulation of histone modification (GO:0031057)2.29860506
154pinocytosis (GO:0006907)2.29319711
155cell-substrate junction assembly (GO:0007044)2.29304472
156negative regulation of mRNA metabolic process (GO:1903312)2.28228517
157peptidyl-threonine modification (GO:0018210)2.23926540
158Golgi transport vesicle coating (GO:0048200)2.23871779
159COPI coating of Golgi vesicle (GO:0048205)2.23871779
160establishment of mitotic spindle localization (GO:0040001)2.23527549
161corticosteroid receptor signaling pathway (GO:0031958)2.23085067
162regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.21656861

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.23700990
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.89176963
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.83768362
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45666492
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.15502387
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.99646454
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81816729
8MYC_22102868_ChIP-Seq_BL_Human2.74560803
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66276539
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45584481
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35987960
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.22404171
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04063218
14XRN2_22483619_ChIP-Seq_HELA_Human1.98740057
15ETS1_20019798_ChIP-Seq_JURKAT_Human1.89652395
16EST1_17652178_ChIP-ChIP_JURKAT_Human1.85698135
17E2F1_21310950_ChIP-Seq_MCF-7_Human1.82115505
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80401998
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.80176614
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80167598
21* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75903347
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75614442
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72920893
24* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72311363
25CIITA_25753668_ChIP-Seq_RAJI_Human1.71117333
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71075537
27* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70857694
28AR_21909140_ChIP-Seq_LNCAP_Human1.70702299
29VDR_23849224_ChIP-Seq_CD4+_Human1.70325154
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68934643
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.68333710
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65789759
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64513069
34* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64081647
35KDM2B_26808549_Chip-Seq_DND41_Human1.63672245
36* FOXP3_21729870_ChIP-Seq_TREG_Human1.63565300
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60643693
38VDR_21846776_ChIP-Seq_THP-1_Human1.59815029
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59403740
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.58726828
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58715250
42VDR_24763502_ChIP-Seq_THP-1_Human1.56789806
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55739147
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54434122
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53172326
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52932750
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52635749
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51473795
49GABP_19822575_ChIP-Seq_HepG2_Human1.50521456
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50511398
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49183492
52KDM5A_27292631_Chip-Seq_BREAST_Human1.47169272
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.43388484
54DCP1A_22483619_ChIP-Seq_HELA_Human1.40410413
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39022632
56TTF2_22483619_ChIP-Seq_HELA_Human1.38541899
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38354779
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37810135
59* RACK7_27058665_Chip-Seq_MCF-7_Human1.37461301
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35203037
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34875638
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34402633
63CLOCK_20551151_ChIP-Seq_293T_Human1.33801952
64* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33313854
65NCOR1_26117541_ChIP-Seq_K562_Human1.31154657
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30481346
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29445143
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.26527143
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26320644
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25420595
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25416346
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24520127
73* TCF7_22412390_ChIP-Seq_EML_Mouse1.24467354
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23890880
75* CHD1_26751641_Chip-Seq_LNCaP_Human1.23450952
76PKCTHETA_26484144_Chip-Seq_BREAST_Human1.23394326
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23271608
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22785937
79MAF_26560356_Chip-Seq_TH2_Human1.21958861
80TFEB_21752829_ChIP-Seq_HELA_Human1.21597250
81* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21306647
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20768872
83ATF3_27146783_Chip-Seq_COLON_Human1.17698157
84* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16724921
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16464317
86LXR_22292898_ChIP-Seq_THP-1_Human1.15759448
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15274159
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14613165
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14256055
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14124809
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13914116
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13483998
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12359365
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12156873
95MAF_26560356_Chip-Seq_TH1_Human1.12039515
96* KDM2B_26808549_Chip-Seq_K562_Human1.11648273
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11598874
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11598874
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11598874
100UTX_26944678_Chip-Seq_JUKART_Human1.10735422
101ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10486723
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10372734
103SCL_19346495_ChIP-Seq_HPC-7_Human1.10368791
104* TP63_19390658_ChIP-ChIP_HaCaT_Human1.10275569
105FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08904739
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08318731
107ELK1_19687146_ChIP-ChIP_HELA_Human1.07511550
108ZNF263_19887448_ChIP-Seq_K562_Human1.06970986
109YY1_21170310_ChIP-Seq_MESCs_Mouse1.06456475
110* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05569003
111* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05099346
112STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04953965
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04744160
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03956456
115* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03896176
116FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03737659
117* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02983222
118STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02928227
119STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02642802
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02409151
121SPI1_23547873_ChIP-Seq_NB4_Human1.02150265
122TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01564686
123NANOG_21062744_ChIP-ChIP_HESCs_Human1.00221898
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99857110
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99843587
126MYB_26560356_Chip-Seq_TH2_Human0.99527383
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99302373
128* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98962392
129* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98962392
130* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98538360
131* UBF1/2_26484160_Chip-Seq_HMECs_Human0.98507923
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98050393
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96803252
134MYB_26560356_Chip-Seq_TH1_Human0.96491770
135CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96267659
136RUNX1_22412390_ChIP-Seq_EML_Mouse0.96175705
137SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95199144
138GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94474680
139MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92509147
140ELK3_25401928_ChIP-Seq_HUVEC_Human0.91695854
141GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89998269
142KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89572427
143RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88178209
144ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87655300

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.28663084
2MP0004957_abnormal_blastocyst_morpholog3.80870143
3MP0010094_abnormal_chromosome_stability3.74196763
4MP0003111_abnormal_nucleus_morphology3.62324087
5MP0008057_abnormal_DNA_replication3.59954878
6MP0003077_abnormal_cell_cycle3.40074877
7MP0010352_gastrointestinal_tract_polyps3.00685558
8MP0002396_abnormal_hematopoietic_system2.84915572
9MP0005451_abnormal_body_composition2.54649821
10MP0004185_abnormal_adipocyte_glucose2.40005320
11MP0008058_abnormal_DNA_repair2.39493190
12MP0008007_abnormal_cellular_replicative2.36327317
13MP0001730_embryonic_growth_arrest2.26398991
14MP0004808_abnormal_hematopoietic_stem2.22536655
15MP0000350_abnormal_cell_proliferation2.22467005
16MP0002009_preneoplasia2.21853376
17MP0010307_abnormal_tumor_latency2.18825610
18MP0010234_abnormal_vibrissa_follicle2.16298985
19MP0000490_abnormal_crypts_of2.11633721
20MP0009278_abnormal_bone_marrow1.92818877
21MP0005397_hematopoietic_system_phenotyp1.92613676
22MP0001545_abnormal_hematopoietic_system1.92613676
23MP0003123_paternal_imprinting1.88687253
24MP0003763_abnormal_thymus_physiology1.86232005
25MP0008932_abnormal_embryonic_tissue1.77047193
26MP0004233_abnormal_muscle_weight1.76612237
27MP0003091_abnormal_cell_migration1.72986018
28MP0001672_abnormal_embryogenesis/_devel1.71826932
29MP0005380_embryogenesis_phenotype1.71826932
30MP0002086_abnormal_extraembryonic_tissu1.69812697
31MP0001697_abnormal_embryo_size1.67545157
32MP0005076_abnormal_cell_differentiation1.66542838
33MP0003453_abnormal_keratinocyte_physiol1.64215885
34MP0003984_embryonic_growth_retardation1.61623746
35MP0005623_abnormal_meninges_morphology1.60124772
36MP0000703_abnormal_thymus_morphology1.59765419
37MP0002088_abnormal_embryonic_growth/wei1.59510918
38MP0002080_prenatal_lethality1.59132505
39MP0002398_abnormal_bone_marrow1.58391083
40MP0004197_abnormal_fetal_growth/weight/1.57754173
41MP0002019_abnormal_tumor_incidence1.56444835
42MP0000685_abnormal_immune_system1.55223542
43MP0002084_abnormal_developmental_patter1.51921547
44MP0003786_premature_aging1.48835706
45MP0002877_abnormal_melanocyte_morpholog1.47047953
46MP0002085_abnormal_embryonic_tissue1.45711634
47MP0006054_spinal_hemorrhage1.43461553
48MP0002722_abnormal_immune_system1.42841082
49MP0000313_abnormal_cell_death1.42840839
50MP0003303_peritoneal_inflammation1.42202215
51MP0005409_darkened_coat_color1.37986406
52MP0008877_abnormal_DNA_methylation1.37742416
53MP0002796_impaired_skin_barrier1.36832256
54MP0009333_abnormal_splenocyte_physiolog1.36258904
55MP0000689_abnormal_spleen_morphology1.35453897
56MP0003656_abnormal_erythrocyte_physiolo1.34751047
57MP0004947_skin_inflammation1.28678798
58MP0003705_abnormal_hypodermis_morpholog1.28414019
59MP0005666_abnormal_adipose_tissue1.23781680
60MP0003567_abnormal_fetal_cardiomyocyte1.21504257
61MP0003191_abnormal_cellular_cholesterol1.19412163
62MP0003828_pulmonary_edema1.18205631
63MP0003566_abnormal_cell_adhesion1.16743784
64MP0005375_adipose_tissue_phenotype1.16158680
65MP0005501_abnormal_skin_physiology1.15141844
66MP0002429_abnormal_blood_cell1.14709311
67MP0005058_abnormal_lysosome_morphology1.13252321
68MP0000858_altered_metastatic_potential1.12479183
69MP0000003_abnormal_adipose_tissue1.10037612
70MP0003806_abnormal_nucleotide_metabolis1.09623749
71MP0002653_abnormal_ependyma_morphology1.08981541
72MP0001800_abnormal_humoral_immune1.08578940
73MP0000716_abnormal_immune_system1.06506881
74MP0003221_abnormal_cardiomyocyte_apopto1.06102627
75MP0005023_abnormal_wound_healing1.05721595
76MP0001346_abnormal_lacrimal_gland1.05609404
77MP0001293_anophthalmia1.05427479
78MP0008260_abnormal_autophagy1.04266006
79MP0001915_intracranial_hemorrhage1.04135029
80MP0010155_abnormal_intestine_physiology1.02540418
81MP0001873_stomach_inflammation1.01740414
82MP0001348_abnormal_lacrimal_gland1.01518429
83MP0003436_decreased_susceptibility_to1.01482295
84MP0004264_abnormal_extraembryonic_tissu0.99591930
85MP0001853_heart_inflammation0.97695470
86MP0000537_abnormal_urethra_morphology0.97500067
87MP0003300_gastrointestinal_ulcer0.95021887
88MP0001216_abnormal_epidermal_layer0.94464280
89MP0000678_abnormal_parathyroid_gland0.92733996
90MP0000477_abnormal_intestine_morphology0.92271017
91MP0003121_genomic_imprinting0.91486977
92MP0002166_altered_tumor_susceptibility0.91052631
93MP0005671_abnormal_response_to0.89530250
94MP0002420_abnormal_adaptive_immunity0.89200553
95MP0002405_respiratory_system_inflammati0.88855113
96MP0001849_ear_inflammation0.88783034
97MP0001819_abnormal_immune_cell0.87769575
98MP0009840_abnormal_foam_cell0.87464115
99MP0005621_abnormal_cell_physiology0.85885862
100MP0000465_gastrointestinal_hemorrhage0.85874838
101MP0002060_abnormal_skin_morphology0.85805408
102MP0002452_abnormal_antigen_presenting0.84465264
103MP0002210_abnormal_sex_determination0.84008574
104MP0003866_abnormal_defecation0.82190238
105MP0001145_abnormal_male_reproductive0.81640744
106MP0003718_maternal_effect0.81511611
107MP0003941_abnormal_skin_development0.81268310
108MP0005384_cellular_phenotype0.80136316
109MP0001835_abnormal_antigen_presentation0.79731269
110MP0009115_abnormal_fat_cell0.79582978
111MP0002998_abnormal_bone_remodeling0.79444149
112MP0003448_altered_tumor_morphology0.78828695
113MP0002132_abnormal_respiratory_system0.78661269
114MP0000358_abnormal_cell_content/0.78000736
115MP0005000_abnormal_immune_tolerance0.77450709
116MP0002723_abnormal_immune_serum0.77049931
117MP0000371_diluted_coat_color0.76076295
118MP0009672_abnormal_birth_weight0.75834199
119MP0010630_abnormal_cardiac_muscle0.73953789
120MP0001929_abnormal_gametogenesis0.73253960
121MP0009703_decreased_birth_body0.72918552
122MP0002970_abnormal_white_adipose0.72316840
123MP0003950_abnormal_plasma_membrane0.72300566
124MP0005464_abnormal_platelet_physiology0.70757079
125MP0005075_abnormal_melanosome_morpholog0.68899982
126MP0000428_abnormal_craniofacial_morphol0.68365530
127MP0008770_decreased_survivor_rate0.68275005
128MP0000733_abnormal_muscle_development0.66374596
129MP0002006_tumorigenesis0.66125731
130MP0002092_abnormal_eye_morphology0.65432138
131MP0003890_abnormal_embryonic-extraembry0.65399659
132MP0003119_abnormal_digestive_system0.65276832
133MP0009053_abnormal_anal_canal0.64048267
134MP0002925_abnormal_cardiovascular_devel0.63383860
135MP0002075_abnormal_coat/hair_pigmentati0.63101977

Predicted human phenotypes

RankGene SetZ-score
1Selective tooth agenesis (HP:0001592)4.49456787
2Abnormality of cells of the erythroid lineage (HP:0012130)3.75748096
3Ependymoma (HP:0002888)3.71798087
4Birth length less than 3rd percentile (HP:0003561)3.63831207
5Reticulocytopenia (HP:0001896)3.54319056
6Abnormal number of erythroid precursors (HP:0012131)3.44166101
7Thrombocytosis (HP:0001894)3.29088159
8Dysmetric saccades (HP:0000641)3.15219905
9Aplastic anemia (HP:0001915)3.14559055
10Ankyloglossia (HP:0010296)3.03663513
11Colon cancer (HP:0003003)3.03170440
12Basal cell carcinoma (HP:0002671)2.98323325
13Medulloblastoma (HP:0002885)2.86399331
14Rhabdomyosarcoma (HP:0002859)2.69157005
15Prominent nose (HP:0000448)2.65484668
16Distal lower limb amyotrophy (HP:0008944)2.65003176
17Myelodysplasia (HP:0002863)2.64015151
18Volvulus (HP:0002580)2.61533978
19Proximal placement of thumb (HP:0009623)2.60379527
20Abnormality of oral frenula (HP:0000190)2.59912215
21Deep philtrum (HP:0002002)2.58423531
22Sparse lateral eyebrow (HP:0005338)2.57029506
23Progressive muscle weakness (HP:0003323)2.53693540
24Deviation of the thumb (HP:0009603)2.53410278
2511 pairs of ribs (HP:0000878)2.49614048
26Pallor (HP:0000980)2.48438542
27Abnormality of the astrocytes (HP:0100707)2.44858451
28Astrocytoma (HP:0009592)2.44858451
29Missing ribs (HP:0000921)2.44246837
30Agnosia (HP:0010524)2.43910409
31Abnormality of the distal phalanx of the thumb (HP:0009617)2.42847110
32Syringomyelia (HP:0003396)2.40415647
33Spinal cord lesions (HP:0100561)2.40415647
34Chromsome breakage (HP:0040012)2.37101189
35Oral leukoplakia (HP:0002745)2.36284490
36IgM deficiency (HP:0002850)2.36054276
37Septate vagina (HP:0001153)2.35331012
38High pitched voice (HP:0001620)2.35258455
39Breast hypoplasia (HP:0003187)2.33453189
40Fatigue (HP:0012378)2.31663635
41Progressive external ophthalmoplegia (HP:0000590)2.29042913
42Increased nuchal translucency (HP:0010880)2.29023818
43Abnormal number of incisors (HP:0011064)2.28556579
44Abnormality of chromosome stability (HP:0003220)2.28019638
45Degeneration of anterior horn cells (HP:0002398)2.24673364
46Abnormality of the anterior horn cell (HP:0006802)2.24673364
47Amaurosis fugax (HP:0100576)2.24476466
48Patellar aplasia (HP:0006443)2.22876011
49Abnormality of the phalanges of the hallux (HP:0010057)2.22585281
50Impulsivity (HP:0100710)2.22214634
51Neoplasm of the oral cavity (HP:0100649)2.21617474
52Absent thumb (HP:0009777)2.21604206
53Flat acetabular roof (HP:0003180)2.21043498
54Macrocytic anemia (HP:0001972)2.20519121
55Long palpebral fissure (HP:0000637)2.20121772
56Neonatal hypoglycemia (HP:0001998)2.18794824
57Centrally nucleated skeletal muscle fibers (HP:0003687)2.18572162
58Deep palmar crease (HP:0006191)2.18456384
59Neoplasm of striated muscle (HP:0009728)2.17833996
60Poikiloderma (HP:0001029)2.16853056
61Abnormality of the labia minora (HP:0012880)2.16323863
62Neoplasm of the pancreas (HP:0002894)2.15159232
63Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14874944
64Persistence of primary teeth (HP:0006335)2.14025247
65Abnormality of the distal phalanges of the toes (HP:0010182)2.13961300
66Short middle phalanx of the 5th finger (HP:0004220)2.13321594
67Carpal bone hypoplasia (HP:0001498)2.12496002
68Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10266275
69Ulnar bowing (HP:0003031)2.08049116
70Multiple enchondromatosis (HP:0005701)2.04735648
71Aplasia/Hypoplasia of the patella (HP:0006498)2.03419244
72Disproportionate tall stature (HP:0001519)2.03192864
73Lymphoma (HP:0002665)2.02294053
74Capillary hemangiomas (HP:0005306)2.01040103
75Squamous cell carcinoma (HP:0002860)2.00609525
76Glioma (HP:0009733)1.99578216
77Cafe-au-lait spot (HP:0000957)1.99235278
78Abnormality of T cells (HP:0002843)1.97333112
79Facial hemangioma (HP:0000329)1.97258396
80Slow saccadic eye movements (HP:0000514)1.97200189
81Long eyelashes (HP:0000527)1.96990791
82High anterior hairline (HP:0009890)1.96300356
83Biliary tract neoplasm (HP:0100574)1.96124131
84Abnormality of the fingertips (HP:0001211)1.94995383
85Asymmetry of the thorax (HP:0001555)1.94433422
86Broad palm (HP:0001169)1.94301049
87Rough bone trabeculation (HP:0100670)1.92797038
88Recurrent viral infections (HP:0004429)1.92700680
89Abnormality of T cell physiology (HP:0011840)1.92253562
90Subacute progressive viral hepatitis (HP:0006572)1.91425745
91Increased connective tissue (HP:0009025)1.91176311
92Heterotopia (HP:0002282)1.89959028
93Atresia of the external auditory canal (HP:0000413)1.88290535
94Achilles tendon contracture (HP:0001771)1.88222876
95Lip pit (HP:0100267)1.87978209
96Abnormality of reticulocytes (HP:0004312)1.86764356
97Renal cell carcinoma (HP:0005584)1.86591511
98Colitis (HP:0002583)1.85390669
99Short 4th metacarpal (HP:0010044)1.84422799
100Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84422799
101Spastic diplegia (HP:0001264)1.84125569
102Adenoma sebaceum (HP:0009720)1.83852889
103Angiofibromas (HP:0010615)1.83852889
104Increased density of long bones (HP:0006392)1.83705300
105Leiomyosarcoma (HP:0100243)1.83177417
106Uterine leiomyosarcoma (HP:0002891)1.83177417
107Asplenia (HP:0001746)1.82883780
108Aplasia/Hypoplasia of the uvula (HP:0010293)1.82822304
109Abnormal delayed hypersensitivity skin test (HP:0002963)1.82755005
110Abnormality of the thoracic spine (HP:0100711)1.82236648
111Premature ovarian failure (HP:0008209)1.81713329
112T lymphocytopenia (HP:0005403)1.81003761
113Acute lymphatic leukemia (HP:0006721)1.80805147
114Broad face (HP:0000283)1.80638987
115Microretrognathia (HP:0000308)1.79967484
116Panhypogammaglobulinemia (HP:0003139)1.79252397
117Premature graying of hair (HP:0002216)1.79215288
118Sandal gap (HP:0001852)1.78909846
119Acute myeloid leukemia (HP:0004808)1.78542416
120Hypoplasia of the pons (HP:0012110)1.77741692
121Termporal pattern (HP:0011008)1.76990238
122Insidious onset (HP:0003587)1.76990238
123Meckel diverticulum (HP:0002245)1.76534503
124Short 5th finger (HP:0009237)1.75892577
125Viral hepatitis (HP:0006562)1.74406166
126Overlapping toe (HP:0001845)1.73894136
127Pelvic girdle muscle weakness (HP:0003749)1.73243913
128Supernumerary spleens (HP:0009799)1.73211523
129Abnormality of the ileum (HP:0001549)1.72959770
130Bone marrow hypocellularity (HP:0005528)1.72840835
131Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.72689304
132Hyperacusis (HP:0010780)1.72482688
133Skin tags (HP:0010609)1.72210002
134Absent radius (HP:0003974)1.71606998
135Abnormality of chromosome segregation (HP:0002916)1.70901637
136Abnormality of the preputium (HP:0100587)1.70855527
137Abnormality of the calcaneus (HP:0008364)1.70522952
138Progressive hearing impairment (HP:0001730)1.70520108
139Osteolytic defects of the hand bones (HP:0009699)1.69875524
140Osteolytic defects of the phalanges of the hand (HP:0009771)1.69875524
141Hypercortisolism (HP:0001578)1.69222782
142Lower limb amyotrophy (HP:0007210)1.68593947
143Abnormal foot bone ossification (HP:0010675)1.67650609
144Aplasia/Hypoplasia of the spleen (HP:0010451)1.67002798
145Dislocated radial head (HP:0003083)1.66625331
146Bowel incontinence (HP:0002607)1.66566093
147Advanced eruption of teeth (HP:0006288)1.66563084
148Cellulitis (HP:0100658)1.65936194
149Trismus (HP:0000211)1.65180025
150Gastrointestinal carcinoma (HP:0002672)1.65046697
151Malignant gastrointestinal tract tumors (HP:0006749)1.65046697
152Myocardial infarction (HP:0001658)1.64914825
153Nasal polyposis (HP:0100582)1.64863933
154Abnormal large intestine physiology (HP:0012700)1.64815850
155Abnormality of the salivary glands (HP:0010286)1.64245303
156Blepharitis (HP:0000498)1.63956589
157Abnormality of T cell number (HP:0011839)1.63839213
158Abnormality of nail color (HP:0100643)1.63773507
159Abnormality of DNA repair (HP:0003254)1.63628969
160Abnormality of the columella (HP:0009929)1.62864364
161Vertebral compression fractures (HP:0002953)1.60711820
162Gastrointestinal inflammation (HP:0004386)1.58411459
163Cubitus valgus (HP:0002967)1.56765350
164Abnormality of the Achilles tendon (HP:0005109)1.56753528
165Relative macrocephaly (HP:0004482)1.55202007
166Natal tooth (HP:0000695)1.53808356
167Aplasia/Hypoplasia of the sacrum (HP:0008517)1.53047367
168Abnormality of the left ventricular outflow tract (HP:0011103)1.52357216
169Subaortic stenosis (HP:0001682)1.52357216
170Macroorchidism (HP:0000053)1.52225311
171Thoracic kyphosis (HP:0002942)1.51088336
172Cerebral aneurysm (HP:0004944)1.51067231
173IgA deficiency (HP:0002720)1.50796322
174Abnormality of the radial head (HP:0003995)1.50198879
175Germ cell neoplasia (HP:0100728)1.48739562
176Transitional cell carcinoma of the bladder (HP:0006740)1.47997666
177Recurrent bacterial skin infections (HP:0005406)1.47916978
178Patellar dislocation (HP:0002999)1.47782352
179Urethral obstruction (HP:0000796)1.47419481
180Obstructive sleep apnea (HP:0002870)1.46636599

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.98812724
2PRPF4B3.72023866
3EEF2K3.52928755
4WEE13.40332465
5SMG12.96040925
6CDK122.73985182
7NEK22.72622704
8IRAK32.63810662
9BUB12.58684444
10PKN22.47861652
11MAP3K102.35639317
12FLT32.32022854
13RPS6KB22.25753470
14MAP4K12.12954654
15STK102.11296173
16PASK1.94783236
17MAP3K131.89848288
18CDK41.87853672
19TTK1.87640651
20RPS6KA41.81268549
21MAP3K141.78376465
22DYRK31.73299049
23TSSK61.70841215
24EIF2AK11.70114563
25TRIB31.68105766
26KSR21.64384559
27NME21.57550732
28CDK71.56479151
29SCYL21.55729869
30MAP3K81.52772221
31NEK11.49827341
32ATR1.48266044
33TGFBR11.46839202
34BRSK21.44419763
35SIK11.41675034
36ACVR1B1.41267135
37PLK11.40569650
38MAP3K91.40408244
39EPHA21.37386820
40LRRK21.34723673
41CDK61.32717495
42ALK1.30946089
43LATS21.25367690
44CAMK1G1.23806029
45AURKB1.23774329
46PAK41.22299199
47STK241.20442013
48PIM11.15278230
49RIPK11.12570447
50CHEK11.12068561
51BRD41.12045005
52SRPK11.07534528
53EIF2AK31.04347140
54GRK61.03852568
55CHEK21.02439968
56IRAK41.01682340
57RIPK41.01125634
58ZAP701.00813224
59TAOK20.97519946
60STK40.95768160
61STK30.94533758
62BTK0.93086088
63TLK10.91231812
64MTOR0.90810141
65TESK20.90078954
66CDK80.89864296
67CLK10.89678486
68JAK30.89127892
69BRAF0.87885714
70MAP2K30.85609270
71VRK10.84198914
72NEK90.83899389
73CDK20.82982380
74ATM0.80466415
75PTK60.78144145
76ARAF0.77365743
77MAPKAPK30.76160233
78CSF1R0.75828936
79TYK20.75535424
80DMPK0.75419019
81IRAK20.75171759
82CDC42BPA0.71851604
83LATS10.70187264
84KIT0.69752290
85MKNK10.69138724
86MARK20.68756941
87MOS0.68586640
88MAP3K110.67879501
89ICK0.67488956
90PLK30.67088318
91MAP3K10.67013252
92MELK0.62939724
93MARK30.62827413
94BLK0.62719059
95CDK90.61964457
96MKNK20.60823028
97PDGFRB0.60551590
98PDPK10.59448145
99BRSK10.59324846
100AURKA0.58730770
101MAP2K20.58307668
102MST1R0.55952073
103YES10.55677935
104TYRO30.55386984
105PLK40.54878709
106KSR10.54295245
107CSNK2A20.54270934
108PAK20.53100146
109MAP3K20.52445279
110CAMK1D0.50824550
111MAPK110.49923216
112JAK10.49453734
113PIM20.48948234
114MATK0.48801694
115TAOK10.48215376
116BMX0.47231250
117TTN0.46370836
118FGFR40.44638815
119ITK0.43881412
120PTK20.43314039
121TRPM70.42915543
122CDK10.41951810
123TBK10.40510010
124RPS6KC10.40308782
125RPS6KL10.40308782
126PRKCI0.39732342
127RPS6KA50.39543736
128KDR0.39446398
129MAP3K30.37149760
130PAK10.36808773
131HIPK20.36173328
132RAF10.35649524
133CSNK2A10.34442763
134PDGFRA0.33414064
135IKBKB0.33099273
136STK160.33050114
137ERN10.32251537
138TEC0.32212850
139CHUK0.31987266
140CSK0.31502060
141AKT20.30259333
142MAPK10.30092296
143ILK0.29777550
144RPS6KA10.29238214

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.47736426
2Mismatch repair_Homo sapiens_hsa034303.64098851
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35237679
4RNA transport_Homo sapiens_hsa030132.98356259
5One carbon pool by folate_Homo sapiens_hsa006702.87855049
6Spliceosome_Homo sapiens_hsa030402.83749259
7Ribosome_Homo sapiens_hsa030102.83616507
8Cell cycle_Homo sapiens_hsa041102.67971393
9Base excision repair_Homo sapiens_hsa034102.58819967
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40029456
11Nucleotide excision repair_Homo sapiens_hsa034202.38961566
12RNA polymerase_Homo sapiens_hsa030202.26799154
13Homologous recombination_Homo sapiens_hsa034402.19572528
14Non-homologous end-joining_Homo sapiens_hsa034501.87418948
15Pyrimidine metabolism_Homo sapiens_hsa002401.82577225
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82368918
17mRNA surveillance pathway_Homo sapiens_hsa030151.81301313
18RNA degradation_Homo sapiens_hsa030181.66486268
19p53 signaling pathway_Homo sapiens_hsa041151.65628237
20Fanconi anemia pathway_Homo sapiens_hsa034601.61323072
21Renal cell carcinoma_Homo sapiens_hsa052111.59201096
22Antigen processing and presentation_Homo sapiens_hsa046121.52460597
23Viral carcinogenesis_Homo sapiens_hsa052031.38918143
24Primary immunodeficiency_Homo sapiens_hsa053401.33339205
25* Herpes simplex infection_Homo sapiens_hsa051681.29186302
26Proteasome_Homo sapiens_hsa030501.28695509
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28068211
28VEGF signaling pathway_Homo sapiens_hsa043701.27906271
29Systemic lupus erythematosus_Homo sapiens_hsa053221.26359484
30* Basal transcription factors_Homo sapiens_hsa030221.23878574
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21533555
32Epstein-Barr virus infection_Homo sapiens_hsa051691.19913352
33ErbB signaling pathway_Homo sapiens_hsa040121.15741020
34Glioma_Homo sapiens_hsa052141.10508893
35Thyroid cancer_Homo sapiens_hsa052161.09033419
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07403365
37Chronic myeloid leukemia_Homo sapiens_hsa052201.06111457
38Small cell lung cancer_Homo sapiens_hsa052221.05345787
39Acute myeloid leukemia_Homo sapiens_hsa052211.04682504
40TNF signaling pathway_Homo sapiens_hsa046681.02694312
41Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02548303
42Insulin signaling pathway_Homo sapiens_hsa049101.02440071
43HTLV-I infection_Homo sapiens_hsa051661.01558815
44Other glycan degradation_Homo sapiens_hsa005110.98897552
45Inositol phosphate metabolism_Homo sapiens_hsa005620.98336031
46Selenocompound metabolism_Homo sapiens_hsa004500.97654898
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96051504
48Hepatitis C_Homo sapiens_hsa051600.96009699
49Colorectal cancer_Homo sapiens_hsa052100.94300712
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93142843
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91825484
52Biosynthesis of amino acids_Homo sapiens_hsa012300.91589162
53MicroRNAs in cancer_Homo sapiens_hsa052060.88581866
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87178665
55Prion diseases_Homo sapiens_hsa050200.86531164
56Hepatitis B_Homo sapiens_hsa051610.83831103
57Dorso-ventral axis formation_Homo sapiens_hsa043200.83270680
58Pentose phosphate pathway_Homo sapiens_hsa000300.81673005
59mTOR signaling pathway_Homo sapiens_hsa041500.81409800
60Purine metabolism_Homo sapiens_hsa002300.81261183
61Sulfur relay system_Homo sapiens_hsa041220.80916963
62Apoptosis_Homo sapiens_hsa042100.79640908
63Measles_Homo sapiens_hsa051620.78864598
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78454236
65B cell receptor signaling pathway_Homo sapiens_hsa046620.77759806
66Choline metabolism in cancer_Homo sapiens_hsa052310.76350429
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.75998062
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.75030976
69Legionellosis_Homo sapiens_hsa051340.74767015
70Focal adhesion_Homo sapiens_hsa045100.74341926
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.74314495
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.72203086
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70693765
74Notch signaling pathway_Homo sapiens_hsa043300.70687425
75Oocyte meiosis_Homo sapiens_hsa041140.70637252
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70322445
77T cell receptor signaling pathway_Homo sapiens_hsa046600.69607940
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.68721851
79Folate biosynthesis_Homo sapiens_hsa007900.68671533
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.67926962
81Estrogen signaling pathway_Homo sapiens_hsa049150.67278079
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.67116204
83Insulin resistance_Homo sapiens_hsa049310.65792487
84Shigellosis_Homo sapiens_hsa051310.63464383
85Lysine degradation_Homo sapiens_hsa003100.63169829
86Pancreatic cancer_Homo sapiens_hsa052120.62944469
87AMPK signaling pathway_Homo sapiens_hsa041520.62107229
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.62052220
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61796356
90Non-small cell lung cancer_Homo sapiens_hsa052230.60509118
91GnRH signaling pathway_Homo sapiens_hsa049120.60013828
92Tuberculosis_Homo sapiens_hsa051520.58411512
93Bladder cancer_Homo sapiens_hsa052190.57678708
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57499382
95N-Glycan biosynthesis_Homo sapiens_hsa005100.56636575
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54656430
97Melanoma_Homo sapiens_hsa052180.54402732
98Toxoplasmosis_Homo sapiens_hsa051450.53602283
99Amoebiasis_Homo sapiens_hsa051460.53105977
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52285988
101Influenza A_Homo sapiens_hsa051640.51929885
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.51261106
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51207199
104Chemokine signaling pathway_Homo sapiens_hsa040620.50581124
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50464865
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49027517
107Hematopoietic cell lineage_Homo sapiens_hsa046400.48148338
108TGF-beta signaling pathway_Homo sapiens_hsa043500.46939706
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45827576
110Pathways in cancer_Homo sapiens_hsa052000.45659769
111Vitamin B6 metabolism_Homo sapiens_hsa007500.44711726
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44636185
113HIF-1 signaling pathway_Homo sapiens_hsa040660.44519036
114Hippo signaling pathway_Homo sapiens_hsa043900.44457105
115Alcoholism_Homo sapiens_hsa050340.44297892
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42745282
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42701969
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42545654
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.41754325
120FoxO signaling pathway_Homo sapiens_hsa040680.40042804
121Viral myocarditis_Homo sapiens_hsa054160.39659690
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39399821
123Endometrial cancer_Homo sapiens_hsa052130.39107278
124Prolactin signaling pathway_Homo sapiens_hsa049170.37040632
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.36802160
126Adherens junction_Homo sapiens_hsa045200.34672044
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34240232
128Carbon metabolism_Homo sapiens_hsa012000.34138089
129Prostate cancer_Homo sapiens_hsa052150.32478915
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.31725602
131Osteoclast differentiation_Homo sapiens_hsa043800.31007091
132Leishmaniasis_Homo sapiens_hsa051400.30490851
133Proteoglycans in cancer_Homo sapiens_hsa052050.30484832

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