TAF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.84446078
2COPI coating of Golgi vesicle (GO:0048205)4.77308642
3Golgi transport vesicle coating (GO:0048200)4.77308642
4telomere maintenance via semi-conservative replication (GO:0032201)4.77057622
5DNA strand elongation (GO:0022616)4.65096437
6DNA replication initiation (GO:0006270)4.60409946
7protein retention in ER lumen (GO:0006621)4.49911186
8proline biosynthetic process (GO:0006561)4.47253541
9planar cell polarity pathway involved in neural tube closure (GO:0090179)4.41076486
10peptidyl-arginine omega-N-methylation (GO:0035247)4.38566694
11telomere maintenance via recombination (GO:0000722)4.30686862
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.27771526
13DNA replication checkpoint (GO:0000076)4.22530773
14DNA deamination (GO:0045006)4.11865926
15mitotic recombination (GO:0006312)4.09432995
16regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.98344277
17regulation of mammary gland epithelial cell proliferation (GO:0033599)3.98005088
18regulation of translational fidelity (GO:0006450)3.95323573
19protein-DNA complex disassembly (GO:0032986)3.87341943
20nucleosome disassembly (GO:0006337)3.87341943
21protein localization to kinetochore (GO:0034501)3.85714590
22telomere maintenance via telomere lengthening (GO:0010833)3.84935471
23heterochromatin organization (GO:0070828)3.83909909
24spliceosomal tri-snRNP complex assembly (GO:0000244)3.81608097
25histone arginine methylation (GO:0034969)3.81416552
26ribosomal small subunit assembly (GO:0000028)3.81337679
27retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.80526527
28DNA unwinding involved in DNA replication (GO:0006268)3.80145470
29DNA replication-dependent nucleosome assembly (GO:0006335)3.78404416
30DNA replication-dependent nucleosome organization (GO:0034723)3.78404416
31pentose-phosphate shunt (GO:0006098)3.74449561
32CENP-A containing nucleosome assembly (GO:0034080)3.74124206
33mitotic metaphase plate congression (GO:0007080)3.74050089
34chromatin remodeling at centromere (GO:0031055)3.73412553
35nucleotide-excision repair, DNA gap filling (GO:0006297)3.66540456
36peptidyl-arginine methylation (GO:0018216)3.65294803
37peptidyl-arginine N-methylation (GO:0035246)3.65294803
38negative regulation of cell size (GO:0045792)3.64624002
39adherens junction assembly (GO:0034333)3.64281489
40kinetochore organization (GO:0051383)3.63489411
41kinetochore assembly (GO:0051382)3.55344091
42protein maturation by protein folding (GO:0022417)3.54086425
43mitotic sister chromatid segregation (GO:0000070)3.47942239
44apoptotic process involved in morphogenesis (GO:0060561)3.47440424
45intra-S DNA damage checkpoint (GO:0031573)3.47387977
46protein localization to chromosome, centromeric region (GO:0071459)3.46439863
47DNA replication-independent nucleosome organization (GO:0034724)3.44213041
48DNA replication-independent nucleosome assembly (GO:0006336)3.44213041
49meiotic chromosome segregation (GO:0045132)3.44024680
50maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.43375056
51cell-substrate adherens junction assembly (GO:0007045)3.39252451
52focal adhesion assembly (GO:0048041)3.39252451
53attachment of spindle microtubules to kinetochore (GO:0008608)3.39026394
54metaphase plate congression (GO:0051310)3.38466405
55mitotic nuclear envelope disassembly (GO:0007077)3.37745120
56somatic diversification of immune receptors via somatic mutation (GO:0002566)3.37215028
57somatic hypermutation of immunoglobulin genes (GO:0016446)3.37215028
58negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.36768907
59IMP biosynthetic process (GO:0006188)3.36750819
60nucleobase biosynthetic process (GO:0046112)3.35281915
61glucose catabolic process (GO:0006007)3.30304823
62nuclear envelope reassembly (GO:0031468)3.29655827
63mitotic nuclear envelope reassembly (GO:0007084)3.29655827
64negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.27234509
65NADPH regeneration (GO:0006740)3.26919220
66transcription-coupled nucleotide-excision repair (GO:0006283)3.25098161
67regulation of nuclear cell cycle DNA replication (GO:0033262)3.24597134
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.23870522
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.23870522
70mismatch repair (GO:0006298)3.23824515
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23637777
72deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.22459738
73convergent extension (GO:0060026)3.22038029
74telomere maintenance (GO:0000723)3.21339886
75maturation of SSU-rRNA (GO:0030490)3.20189781
76intracellular estrogen receptor signaling pathway (GO:0030520)3.19560668
77regulation of double-strand break repair via homologous recombination (GO:0010569)3.19363402
78spliceosomal snRNP assembly (GO:0000387)3.18750307
79telomere organization (GO:0032200)3.18308416
80mitotic chromosome condensation (GO:0007076)3.17902277
81ribosome biogenesis (GO:0042254)3.15912233
82purine nucleobase biosynthetic process (GO:0009113)3.15747932
83semaphorin-plexin signaling pathway (GO:0071526)3.14813828
84rRNA modification (GO:0000154)3.14094715
85histone exchange (GO:0043486)3.13946706
86protein complex localization (GO:0031503)3.13603913
87replication fork processing (GO:0031297)3.12175537
88establishment of chromosome localization (GO:0051303)3.12157038
89negative regulation of chromosome segregation (GO:0051985)3.10705915
90negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.10117036
91negative regulation of sister chromatid segregation (GO:0033046)3.10117036
92negative regulation of mitotic sister chromatid separation (GO:2000816)3.10117036
93negative regulation of mitotic sister chromatid segregation (GO:0033048)3.10117036
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06936913
95formation of translation preinitiation complex (GO:0001731)3.06480929
96proline metabolic process (GO:0006560)3.06472169
97glucose 6-phosphate metabolic process (GO:0051156)3.05291285
98protein targeting to plasma membrane (GO:0072661)3.04224027
99negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.03030212
100sister chromatid segregation (GO:0000819)3.02999268
101activation of Rac GTPase activity (GO:0032863)3.02301312
102maternal placenta development (GO:0001893)3.02196120
103viral mRNA export from host cell nucleus (GO:0046784)3.02014062
104spindle assembly checkpoint (GO:0071173)3.00876359
105rRNA methylation (GO:0031167)2.99751071
106base-excision repair (GO:0006284)2.98473804
107membrane disassembly (GO:0030397)2.97571515
108nuclear envelope disassembly (GO:0051081)2.97571515
109DNA ligation (GO:0006266)2.97492998
110mitotic spindle assembly checkpoint (GO:0007094)2.96600777
111cytoskeletal anchoring at plasma membrane (GO:0007016)2.94916756
112nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94775706
113synaptic vesicle docking involved in exocytosis (GO:0016081)2.94662548
114regulation of early endosome to late endosome transport (GO:2000641)2.94099753
115IMP metabolic process (GO:0046040)2.93952363
116spindle checkpoint (GO:0031577)2.93862965
117histone H2A acetylation (GO:0043968)2.92191798
118snRNA metabolic process (GO:0016073)2.91201474
119basement membrane organization (GO:0071711)2.88716657
120establishment of viral latency (GO:0019043)2.87154233
121nuclear pore organization (GO:0006999)2.86942381
122regulation of chromosome segregation (GO:0051983)2.86549701
123L-serine metabolic process (GO:0006563)2.86036155
124positive regulation of DNA-dependent DNA replication (GO:2000105)2.86034211
125spliceosomal complex assembly (GO:0000245)2.86001352
126establishment of integrated proviral latency (GO:0075713)2.83877356
127anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.83850894
128DNA-dependent DNA replication (GO:0006261)2.81064604
129DNA catabolic process, exonucleolytic (GO:0000738)2.81027669
130regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80997007
131DNA replication (GO:0006260)2.80888680
132protein K6-linked ubiquitination (GO:0085020)2.80680744
133mitotic spindle checkpoint (GO:0071174)2.80671177
134cullin deneddylation (GO:0010388)2.80124240
135termination of RNA polymerase III transcription (GO:0006386)2.79682311
136transcription elongation from RNA polymerase III promoter (GO:0006385)2.79682311
137microtubule depolymerization (GO:0007019)2.79524011
138rRNA processing (GO:0006364)2.79303972
139cellular protein complex localization (GO:0034629)2.79177078
140positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.79065987
141maturation of 5.8S rRNA (GO:0000460)2.78432636
142ribonucleoprotein complex biogenesis (GO:0022613)2.78396736
143adenine nucleotide transport (GO:0051503)2.78146258
144postreplication repair (GO:0006301)2.78115970
145translesion synthesis (GO:0019985)2.78092033
146regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77852630
147DNA duplex unwinding (GO:0032508)2.77399279
148regulation of sister chromatid segregation (GO:0033045)2.76623021
149regulation of mitotic sister chromatid separation (GO:0010965)2.76623021
150regulation of mitotic sister chromatid segregation (GO:0033047)2.76623021
151DNA geometric change (GO:0032392)2.76300636
152positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.75784080
153Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.75668449
154regulation of chromatin binding (GO:0035561)2.75367385
155activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.72577399
156establishment of apical/basal cell polarity (GO:0035089)2.71678076
157positive regulation of nuclease activity (GO:0032075)2.71228645
158mitotic G1 DNA damage checkpoint (GO:0031571)2.69480269
159mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.65690280
160cellular response to epidermal growth factor stimulus (GO:0071364)2.61655982
161modulation by virus of host morphology or physiology (GO:0019048)2.60768572
162regulation of mitotic spindle organization (GO:0060236)2.60374350
163negative regulation of mRNA processing (GO:0050686)2.59688518
164protein export from nucleus (GO:0006611)2.57991677
165regulation of establishment of planar polarity (GO:0090175)2.56849193
166barbed-end actin filament capping (GO:0051016)2.53859052
167cell migration in hindbrain (GO:0021535)2.53089487
168UV protection (GO:0009650)2.50128738
169protein insertion into membrane (GO:0051205)2.49454300
170positive regulation of synapse maturation (GO:0090129)2.49231237
171snRNA processing (GO:0016180)2.48312790
172cell-substrate junction assembly (GO:0007044)2.48132040
173negative regulation of microtubule polymerization (GO:0031115)2.48062277
174negative regulation of mRNA metabolic process (GO:1903312)2.47211950
175glucocorticoid receptor signaling pathway (GO:0042921)2.46420208
1763-UTR-mediated mRNA stabilization (GO:0070935)2.46194522
177glycolytic process (GO:0006096)2.44001615
178RNA localization (GO:0006403)2.43519504
179cochlea morphogenesis (GO:0090103)2.43316866
180neural tube development (GO:0021915)2.39921781
181regulation of nuclease activity (GO:0032069)2.39896969
182regulation of glucose import in response to insulin stimulus (GO:2001273)2.39086434
183epithelial cell-cell adhesion (GO:0090136)2.37777820
184endoplasmic reticulum unfolded protein response (GO:0030968)2.37586639
185atrioventricular valve morphogenesis (GO:0003181)2.37043795
186cell-cell junction maintenance (GO:0045217)2.36410697
187negative regulation of DNA-templated transcription, elongation (GO:0032785)2.36076486
188paraxial mesoderm development (GO:0048339)2.35178388
189protein localization to endosome (GO:0036010)2.34422649
190peptidyl-arginine modification (GO:0018195)2.33176081
191modulation by virus of host process (GO:0019054)2.33077817
192regulation of RNA export from nucleus (GO:0046831)2.32637810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.83897291
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.16066758
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.98853130
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.92122275
5* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61575454
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.56309395
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16112739
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08176286
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.06320704
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.95483592
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.88174356
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.78682287
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.78556915
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77982581
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72596027
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.68485124
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61490926
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41874023
19LXR_22292898_ChIP-Seq_THP-1_Human2.41342260
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35047381
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29092582
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.28541409
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.25014789
24XRN2_22483619_ChIP-Seq_HELA_Human2.24770702
25* FOXP3_21729870_ChIP-Seq_TREG_Human2.24411651
26VDR_23849224_ChIP-Seq_CD4+_Human2.23284763
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20082979
28TP63_19390658_ChIP-ChIP_HaCaT_Human2.19889912
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19301240
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.18406350
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17601945
32* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15263410
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.07042342
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05802190
35* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02750258
36* E2F1_21310950_ChIP-Seq_MCF-7_Human2.00199661
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00150322
38RACK7_27058665_Chip-Seq_MCF-7_Human1.99586168
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99510037
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.98863453
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.93328185
42DCP1A_22483619_ChIP-Seq_HELA_Human1.91265864
43ZNF263_19887448_ChIP-Seq_K562_Human1.89739601
44GABP_19822575_ChIP-Seq_HepG2_Human1.88066213
45* CIITA_25753668_ChIP-Seq_RAJI_Human1.87057150
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86945664
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.84459340
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81613744
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80769612
50* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79792157
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79225305
52* TTF2_22483619_ChIP-Seq_HELA_Human1.78644594
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76955498
54* TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75963014
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72650770
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.69675209
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69419975
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67433818
59KDM2B_26808549_Chip-Seq_DND41_Human1.65150912
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64733424
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.63129591
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62479172
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62156525
64P68_20966046_ChIP-Seq_HELA_Human1.60734119
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59940837
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59071623
67AR_21909140_ChIP-Seq_LNCAP_Human1.57639061
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57162608
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56749087
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55772323
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54247687
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.53724382
73TCF7_22412390_ChIP-Seq_EML_Mouse1.53537932
74KDM2B_26808549_Chip-Seq_K562_Human1.52250230
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49270122
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48150109
77ELK1_19687146_ChIP-ChIP_HELA_Human1.45409138
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43161998
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42979980
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42940537
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.40545131
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39811109
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39590513
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39255362
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37988774
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37520822
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34828405
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.32815952
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32497090
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32368991
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32248177
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30970685
93SMC4_20622854_ChIP-Seq_HELA_Human1.30581582
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29955098
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29165715
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27955074
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27743049
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25297967
99CREB1_26743006_Chip-Seq_LNCaP_Human1.25238435
100MYC_22102868_ChIP-Seq_BL_Human1.23739011
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23510091
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21767768
103CLOCK_20551151_ChIP-Seq_293T_Human1.20892999
104SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20883591
105KDM5A_27292631_Chip-Seq_BREAST_Human1.20647562
106* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.20001935
107MYC_18940864_ChIP-ChIP_HL60_Human1.17910840
108ELF1_20517297_ChIP-Seq_JURKAT_Human1.17798876
109ATF3_27146783_Chip-Seq_COLON_Human1.15271129
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14602490
111NCOR1_26117541_ChIP-Seq_K562_Human1.14015358
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13783306
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13780390
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12727053
115KDM2B_26808549_Chip-Seq_JURKAT_Human1.12324354
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12205436
117PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11827122
118TP53_22127205_ChIP-Seq_IMR90_Human1.11578286
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11334487
120SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10472260
121ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10361835
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09962715
123FOXP1_21924763_ChIP-Seq_HESCs_Human1.09638937
124* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09539502
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08779736
126SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08776596
127* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07172500
128DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07169820
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06726313
130RARA_24833708_ChIP-Seq_LIVER_Mouse1.06388345
131ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04746345
132RARB_24833708_ChIP-Seq_LIVER_Mouse1.01569240
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01440386
134* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01429822
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01101688
136BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00129471
137MAF_26560356_Chip-Seq_TH2_Human0.99691025
138CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99497219
139MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99179757
140IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89140392
141KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88243127
142KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88243127
143KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88243127
144SPI1_23547873_ChIP-Seq_NB4_Human0.88057758
145TFEB_21752829_ChIP-Seq_HELA_Human0.87364627
146CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86594787
147KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86072407
148SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85255205
149CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83839980
150* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81633511
151STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81595586
152IRF1_19129219_ChIP-ChIP_H3396_Human0.81128564
153CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79420756
154NANOG_21062744_ChIP-ChIP_HESCs_Human0.77958224
155POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75651340
156* YY1_22570637_ChIP-Seq_MALME-3M_Human0.73037686
157CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72898232
158VDR_21846776_ChIP-Seq_THP-1_Human0.70632494
159EGR1_19374776_ChIP-ChIP_THP-1_Human0.70404473
160NANOG_16153702_ChIP-ChIP_HESCs_Human0.69753938
161CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.68900529
162RBPJ_22232070_ChIP-Seq_NCS_Mouse0.68657141
163NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.67902185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.78702441
2MP0010094_abnormal_chromosome_stability4.59227906
3MP0003705_abnormal_hypodermis_morpholog4.40981503
4MP0003111_abnormal_nucleus_morphology4.00287222
5MP0008057_abnormal_DNA_replication3.94128584
6MP0008058_abnormal_DNA_repair3.87822516
7MP0003077_abnormal_cell_cycle3.67239818
8MP0004957_abnormal_blastocyst_morpholog3.66213087
9MP0008007_abnormal_cellular_replicative3.04682970
10MP0008877_abnormal_DNA_methylation2.94388817
11MP0006292_abnormal_olfactory_placode2.77020078
12MP0004858_abnormal_nervous_system2.73963574
13MP0001849_ear_inflammation2.72114000
14MP0008438_abnormal_cutaneous_collagen2.71955815
15MP0008932_abnormal_embryonic_tissue2.56189840
16MP0003786_premature_aging2.38136200
17MP0005076_abnormal_cell_differentiation2.38002609
18MP0000751_myopathy2.23610963
19MP0004233_abnormal_muscle_weight2.21142373
20MP0004859_abnormal_synaptic_plasticity2.19202599
21MP0003123_paternal_imprinting2.17093480
22MP0002396_abnormal_hematopoietic_system2.11311656
23MP0001348_abnormal_lacrimal_gland2.09054835
24MP0003566_abnormal_cell_adhesion2.07936774
25MP0003121_genomic_imprinting2.04418646
26MP0005623_abnormal_meninges_morphology1.93742610
27MP0009672_abnormal_birth_weight1.88537902
28MP0004272_abnormal_basement_membrane1.84751825
29MP0005257_abnormal_intraocular_pressure1.82553447
30MP0008260_abnormal_autophagy1.78788563
31MP0000350_abnormal_cell_proliferation1.70582533
32MP0001730_embryonic_growth_arrest1.68294048
33MP0010030_abnormal_orbit_morphology1.67661099
34MP0002653_abnormal_ependyma_morphology1.66963051
35MP0002089_abnormal_postnatal_growth/wei1.59968140
36MP0009278_abnormal_bone_marrow1.59901018
37MP0004808_abnormal_hematopoietic_stem1.59660313
38MP0002210_abnormal_sex_determination1.59132792
39MP0005451_abnormal_body_composition1.57736100
40MP0000490_abnormal_crypts_of1.55967985
41MP0003763_abnormal_thymus_physiology1.48499198
42MP0000566_synostosis1.46194601
43MP0005171_absent_coat_pigmentation1.46029779
44MP0005058_abnormal_lysosome_morphology1.44948496
45MP0001672_abnormal_embryogenesis/_devel1.44669792
46MP0005380_embryogenesis_phenotype1.44669792
47MP0004185_abnormal_adipocyte_glucose1.44139376
48MP0000313_abnormal_cell_death1.42925862
49MP0001929_abnormal_gametogenesis1.42440207
50MP0005501_abnormal_skin_physiology1.41064393
51MP0002102_abnormal_ear_morphology1.39942772
52MP0003942_abnormal_urinary_system1.39169399
53MP0003315_abnormal_perineum_morphology1.39099226
54MP0000003_abnormal_adipose_tissue1.38908955
55MP0000534_abnormal_ureter_morphology1.38837965
56MP0000678_abnormal_parathyroid_gland1.36734185
57MP0001697_abnormal_embryo_size1.34957805
58MP0008995_early_reproductive_senescence1.34897839
59MP0003718_maternal_effect1.29618038
60MP0001145_abnormal_male_reproductive1.28676875
61MP0003984_embryonic_growth_retardation1.27466662
62MP0002085_abnormal_embryonic_tissue1.25035454
63MP0002019_abnormal_tumor_incidence1.24934070
64MP0002132_abnormal_respiratory_system1.22580524
65MP0002088_abnormal_embryonic_growth/wei1.22544280
66MP0000733_abnormal_muscle_development1.22395665
67MP0003122_maternal_imprinting1.21246208
68MP0002080_prenatal_lethality1.20903822
69MP0000703_abnormal_thymus_morphology1.20016450
70MP0000049_abnormal_middle_ear1.19776898
71MP0003115_abnormal_respiratory_system1.18250369
72MP0009053_abnormal_anal_canal1.18041221
73MP0001346_abnormal_lacrimal_gland1.17948057
74MP0009333_abnormal_splenocyte_physiolog1.12993743
75MP0008789_abnormal_olfactory_epithelium1.12938218
76MP0000750_abnormal_muscle_regeneration1.12051975
77MP0000653_abnormal_sex_gland1.11551828
78MP0005508_abnormal_skeleton_morphology1.11309254
79MP0005075_abnormal_melanosome_morpholog1.10863049
80MP0003385_abnormal_body_wall1.08607513
81MP0002160_abnormal_reproductive_system1.08249876
82MP0002060_abnormal_skin_morphology1.07797803
83MP0000747_muscle_weakness1.07509239
84MP0009697_abnormal_copulation1.06855451
85MP0000759_abnormal_skeletal_muscle1.06180429
86MP0003890_abnormal_embryonic-extraembry1.05932785
87MP0005621_abnormal_cell_physiology1.05463318
88MP0002398_abnormal_bone_marrow1.04689216
89MP0002938_white_spotting1.02892316
90MP0003329_amyloid_beta_deposits1.01931253
91MP0003861_abnormal_nervous_system1.01495224
92MP0002697_abnormal_eye_size1.00989926
93MP0002084_abnormal_developmental_patter0.99306332
94MP0002796_impaired_skin_barrier0.99156634
95MP0003698_abnormal_male_reproductive0.99142582
96MP0009384_cardiac_valve_regurgitation0.96781421
97MP0010630_abnormal_cardiac_muscle0.96773864
98MP0002086_abnormal_extraembryonic_tissu0.96258043
99MP0001293_anophthalmia0.96168065
100MP0002722_abnormal_immune_system0.95245983
101MP0003787_abnormal_imprinting0.95204796
102MP0010307_abnormal_tumor_latency0.94172065
103MP0001119_abnormal_female_reproductive0.93947862
104MP0001299_abnormal_eye_distance/0.93893288
105MP0005410_abnormal_fertilization0.93763868
106MP0004197_abnormal_fetal_growth/weight/0.93375857
107MP0002254_reproductive_system_inflammat0.91777401
108MP0000689_abnormal_spleen_morphology0.91150543
109MP0002116_abnormal_craniofacial_bone0.91029975
110MP0003567_abnormal_fetal_cardiomyocyte0.90585625
111MP0000467_abnormal_esophagus_morphology0.90407741
112MP0002127_abnormal_cardiovascular_syste0.89876250
113MP0004087_abnormal_muscle_fiber0.89681808
114MP0000462_abnormal_digestive_system0.89099686
115MP0002877_abnormal_melanocyte_morpholog0.88997189
116MP0003091_abnormal_cell_migration0.88387710
117MP0010234_abnormal_vibrissa_follicle0.86832322
118MP0003453_abnormal_keratinocyte_physiol0.86751755
119MP0001986_abnormal_taste_sensitivity0.86265452
120MP0005384_cellular_phenotype0.85816604
121MP0003119_abnormal_digestive_system0.85291380
122MP0005397_hematopoietic_system_phenotyp0.84979859
123MP0001545_abnormal_hematopoietic_system0.84979859
124MP0002932_abnormal_joint_morphology0.84952533
125MP0000428_abnormal_craniofacial_morphol0.84799842
126MP0005503_abnormal_tendon_morphology0.83515852
127MP0005389_reproductive_system_phenotype0.83208334
128MP0005409_darkened_coat_color0.82337556
129MP0000613_abnormal_salivary_gland0.81427744
130MP0005330_cardiomyopathy0.79983254
131MP0000537_abnormal_urethra_morphology0.79887965
132MP0002114_abnormal_axial_skeleton0.79283605
133MP0005375_adipose_tissue_phenotype0.79210346
134MP0006072_abnormal_retinal_apoptosis0.79090227
135MP0005671_abnormal_response_to0.78048737
136MP0002429_abnormal_blood_cell0.78016147
137MP0005499_abnormal_olfactory_system0.76660447
138MP0005394_taste/olfaction_phenotype0.76660447
139MP0000762_abnormal_tongue_morphology0.76646159
140MP0009703_decreased_birth_body0.76541569
141MP0001958_emphysema0.76337390
142MP0002249_abnormal_larynx_morphology0.76023717
143MP0003172_abnormal_lysosome_physiology0.75896316
144MP0003279_aneurysm0.74821830
145MP0003943_abnormal_hepatobiliary_system0.73994990
146MP0000432_abnormal_head_morphology0.72850121
147MP0001727_abnormal_embryo_implantation0.72400562
148MP0000579_abnormal_nail_morphology0.71762008
149MP0002092_abnormal_eye_morphology0.71405524
150MP0004133_heterotaxia0.71172162
151MP0001340_abnormal_eyelid_morphology0.71000089
152MP0000358_abnormal_cell_content/0.70928035
153MP0002751_abnormal_autonomic_nervous0.70510374
154MP0001919_abnormal_reproductive_system0.70358989
155MP0003221_abnormal_cardiomyocyte_apopto0.70051728
156MP0002925_abnormal_cardiovascular_devel0.69030182
157MP0003937_abnormal_limbs/digits/tail_de0.68835590
158MP0002163_abnormal_gland_morphology0.67478665
159MP0000716_abnormal_immune_system0.65735178
160MP0001853_heart_inflammation0.64911303
161MP0004264_abnormal_extraembryonic_tissu0.64292304
162MP0001286_abnormal_eye_development0.63963519
163MP0002405_respiratory_system_inflammati0.63760242
164MP0003186_abnormal_redox_activity0.63110172
165MP0002161_abnormal_fertility/fecundity0.63009450
166MP0002111_abnormal_tail_morphology0.62950912
167MP0003941_abnormal_skin_development0.62448205
168MP0005379_endocrine/exocrine_gland_phen0.61702587
169MP0002095_abnormal_skin_pigmentation0.61298385
170MP0002234_abnormal_pharynx_morphology0.60772322

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.30101371
2Chromsome breakage (HP:0040012)5.10560647
3Hyperacusis (HP:0010780)4.77257798
4Premature rupture of membranes (HP:0001788)3.91406901
5Birth length less than 3rd percentile (HP:0003561)3.82563894
6Protrusio acetabuli (HP:0003179)3.65111602
7Insomnia (HP:0100785)3.64965220
8Meckel diverticulum (HP:0002245)3.57737805
9Abnormality of the ileum (HP:0001549)3.50195165
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.46460833
11Abnormality of the preputium (HP:0100587)3.39170154
12Abnormality of chromosome stability (HP:0003220)3.36393416
13Aplastic anemia (HP:0001915)3.31531284
14Shallow orbits (HP:0000586)3.29298566
15Reticulocytopenia (HP:0001896)3.28042396
16Abnormality of the anterior horn cell (HP:0006802)3.23606213
17Degeneration of anterior horn cells (HP:0002398)3.23606213
18Upper limb amyotrophy (HP:0009129)3.15443780
19Distal upper limb amyotrophy (HP:0007149)3.15443780
20Ependymoma (HP:0002888)3.12325528
21Ulnar bowing (HP:0003031)3.11491483
22Abnormal gallbladder physiology (HP:0012438)3.09051860
23Cholecystitis (HP:0001082)3.09051860
24Breast hypoplasia (HP:0003187)3.07616803
25Patellar aplasia (HP:0006443)3.07076413
26Broad distal phalanx of finger (HP:0009836)2.99686343
27Nephroblastoma (Wilms tumor) (HP:0002667)2.96818736
28Medulloblastoma (HP:0002885)2.95281173
29Type I transferrin isoform profile (HP:0003642)2.92783010
30Overriding aorta (HP:0002623)2.91913199
31Distal lower limb amyotrophy (HP:0008944)2.89733640
32Small intestinal stenosis (HP:0012848)2.89433943
33Duodenal stenosis (HP:0100867)2.89433943
34Aplasia/Hypoplasia of the patella (HP:0006498)2.86143229
35Broad face (HP:0000283)2.84758635
3611 pairs of ribs (HP:0000878)2.84261798
37Elfin facies (HP:0004428)2.80354434
38Embryonal renal neoplasm (HP:0011794)2.76359770
39Vertebral compression fractures (HP:0002953)2.72148982
40Myelodysplasia (HP:0002863)2.68527304
41Bone marrow hypocellularity (HP:0005528)2.68144712
42Increased connective tissue (HP:0009025)2.67660411
43Long palpebral fissure (HP:0000637)2.67066246
44Hand muscle atrophy (HP:0009130)2.66207142
45Type 2 muscle fiber atrophy (HP:0003554)2.64965325
46Spinal rigidity (HP:0003306)2.64767950
47Achilles tendon contracture (HP:0001771)2.62801672
48Obstructive sleep apnea (HP:0002870)2.60645670
49Duplicated collecting system (HP:0000081)2.60114113
50Renal duplication (HP:0000075)2.56764329
51Lower limb amyotrophy (HP:0007210)2.55333847
52Abnormal lung lobation (HP:0002101)2.54619925
53Biconcave vertebral bodies (HP:0004586)2.53991135
54Absent thumb (HP:0009777)2.51570938
55Selective tooth agenesis (HP:0001592)2.51472666
56Muscle fiber atrophy (HP:0100295)2.48868310
57Centrally nucleated skeletal muscle fibers (HP:0003687)2.48835268
58Ectopic kidney (HP:0000086)2.48284553
59Abnormality of the renal collecting system (HP:0004742)2.47532223
60Impulsivity (HP:0100710)2.47024777
61Abnormal number of erythroid precursors (HP:0012131)2.45682559
62Supernumerary spleens (HP:0009799)2.45087665
63Hypoplasia of the capital femoral epiphysis (HP:0003090)2.44886721
64Pointed chin (HP:0000307)2.42287982
65Disproportionate tall stature (HP:0001519)2.41549709
66Ankle contracture (HP:0006466)2.41397277
67Abnormality of the duodenum (HP:0002246)2.41361272
68Abnormality of dentin (HP:0010299)2.40827180
69Bladder diverticulum (HP:0000015)2.40778814
70Stridor (HP:0010307)2.40548932
71Distal lower limb muscle weakness (HP:0009053)2.39907645
72Oral leukoplakia (HP:0002745)2.36840033
73Clubbing of toes (HP:0100760)2.36760507
74Abnormality of DNA repair (HP:0003254)2.36642308
75Sloping forehead (HP:0000340)2.36567349
76Premature graying of hair (HP:0002216)2.34366153
77Abnormality of the carotid arteries (HP:0005344)2.33924592
78Abnormality of cells of the erythroid lineage (HP:0012130)2.33480044
79Difficulty climbing stairs (HP:0003551)2.31898681
80Turricephaly (HP:0000262)2.30771128
81Myopathic facies (HP:0002058)2.25462120
82Reticulocytosis (HP:0001923)2.25408786
83Abnormality of the Achilles tendon (HP:0005109)2.24600428
84Absent radius (HP:0003974)2.22433321
85Triphalangeal thumb (HP:0001199)2.21425728
86Cerebral aneurysm (HP:0004944)2.20363621
87Abnormal number of incisors (HP:0011064)2.19002106
88Patellar dislocation (HP:0002999)2.18321590
89Volvulus (HP:0002580)2.11431753
90Carpal bone hypoplasia (HP:0001498)2.10677987
91Premature skin wrinkling (HP:0100678)2.10432240
92Cervical subluxation (HP:0003308)2.10170399
93High anterior hairline (HP:0009890)2.09403884
94Flat cornea (HP:0007720)2.08372818
95Bowel diverticulosis (HP:0005222)2.08301705
96Renovascular hypertension (HP:0100817)2.08207775
97Fragile skin (HP:0001030)2.06697083
98Trismus (HP:0000211)2.06168965
99Thrombocytosis (HP:0001894)2.05104517
100Increased variability in muscle fiber diameter (HP:0003557)2.03955103
101Generalized amyotrophy (HP:0003700)2.03627551
102Optic nerve coloboma (HP:0000588)2.02880037
103Arnold-Chiari malformation (HP:0002308)2.02124528
104Absent forearm bone (HP:0003953)2.01605555
105Aplasia involving forearm bones (HP:0009822)2.01605555
106Mitral regurgitation (HP:0001653)1.99135179
107Asymmetry of the thorax (HP:0001555)1.97581400
108Colon cancer (HP:0003003)1.96246271
109Tracheoesophageal fistula (HP:0002575)1.95474296
110Thin ribs (HP:0000883)1.94925511
111Abnormality of skeletal muscle fiber size (HP:0012084)1.94501612
112J-shaped sella turcica (HP:0002680)1.94385431
113Pancytopenia (HP:0001876)1.94053910
114Mildly elevated creatine phosphokinase (HP:0008180)1.93544472
115Annular pancreas (HP:0001734)1.92578997
116Short nail (HP:0001799)1.92574525
117Testicular atrophy (HP:0000029)1.91851309
118Increased nuchal translucency (HP:0010880)1.91794975
119Genu recurvatum (HP:0002816)1.89603239
120Short thumb (HP:0009778)1.89557000
121Cerebral hypomyelination (HP:0006808)1.89368768
122Rib fusion (HP:0000902)1.87890175
123Back pain (HP:0003418)1.87135152
124Truncus arteriosus (HP:0001660)1.87135091
125Precocious puberty (HP:0000826)1.87132943
126Facial cleft (HP:0002006)1.85760677
127Agnosia (HP:0010524)1.84294216
128Rough bone trabeculation (HP:0100670)1.83360799
129Bronchomalacia (HP:0002780)1.83113851
130IgM deficiency (HP:0002850)1.82228997
131Amaurosis fugax (HP:0100576)1.81988737
132Abnormality of the labia minora (HP:0012880)1.81918224
133Neoplasm of the pancreas (HP:0002894)1.81848896
134Aplasia/Hypoplasia of the sternum (HP:0006714)1.81085251
135Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80841079
136Pendular nystagmus (HP:0012043)1.80149112
137Blue sclerae (HP:0000592)1.78733146
138Glioma (HP:0009733)1.78510682
139Urethral obstruction (HP:0000796)1.77822607
140Wormian bones (HP:0002645)1.77106149
141Atelectasis (HP:0100750)1.77066613
142Trigonocephaly (HP:0000243)1.76929537
143Abnormality of the umbilical cord (HP:0010881)1.74458589
144Adducted thumb (HP:0001181)1.74435120
145Microretrognathia (HP:0000308)1.74268860
146Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73707933
147Abnormal protein N-linked glycosylation (HP:0012347)1.73707933
148Abnormal protein glycosylation (HP:0012346)1.73707933
149Abnormal glycosylation (HP:0012345)1.73707933
150Abnormality of reticulocytes (HP:0004312)1.73549181
151Reduced antithrombin III activity (HP:0001976)1.73073690
152Hypercalcemia (HP:0003072)1.72569754
153True hermaphroditism (HP:0010459)1.71918400
154Cleft eyelid (HP:0000625)1.71277093
155Hyperthyroidism (HP:0000836)1.71157340
156Hypoventilation (HP:0002791)1.70706944
157Missing ribs (HP:0000921)1.69909621
158Absent epiphyses (HP:0010577)1.69831304
159Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.69831304
160Deviation of the thumb (HP:0009603)1.69716537
161Proximal placement of thumb (HP:0009623)1.69232275
162Lymphoma (HP:0002665)1.68614819
163Rhabdomyosarcoma (HP:0002859)1.68152336
164Advanced eruption of teeth (HP:0006288)1.67989373
165Midface retrusion (HP:0011800)1.67095601
166Elbow flexion contracture (HP:0002987)1.67065647
167Hypoplasia of the radius (HP:0002984)1.66063192
168Acute lymphatic leukemia (HP:0006721)1.65730384
169Abnormality of the heme biosynthetic pathway (HP:0010472)1.65725434
170Cholelithiasis (HP:0001081)1.65621559
171Abdominal situs inversus (HP:0003363)1.65037003
172Abnormality of abdominal situs (HP:0011620)1.65037003
173Abnormality of the calcaneus (HP:0008364)1.65026425
174Congenital hip dislocation (HP:0001374)1.64434477
175Astrocytoma (HP:0009592)1.64239818
176Abnormality of the astrocytes (HP:0100707)1.64239818
177Abnormal spermatogenesis (HP:0008669)1.63729017
178Deviation of the hallux (HP:0010051)1.63195693
179Pancreatic cysts (HP:0001737)1.62669820
180Intestinal atresia (HP:0011100)1.60877197
181Bowel incontinence (HP:0002607)1.59825435
182Horseshoe kidney (HP:0000085)1.59511894
183Progressive muscle weakness (HP:0003323)1.59269854
184Atresia of the external auditory canal (HP:0000413)1.58817068
185Asplenia (HP:0001746)1.58475904
186Megalocornea (HP:0000485)1.58031421
187Broad metatarsal (HP:0001783)1.57705830
188Hallux valgus (HP:0001822)1.57193688
189Cafe-au-lait spot (HP:0000957)1.56512757
190Spina bifida occulta (HP:0003298)1.55968128
191Abnormality of the tricuspid valve (HP:0001702)1.55848383
192Partial duplication of thumb phalanx (HP:0009944)1.54405669
193Duplication of thumb phalanx (HP:0009942)1.54174062
194Pseudobulbar signs (HP:0002200)1.53648423
195Natal tooth (HP:0000695)1.51788117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.69252537
2STK164.42303376
3BUB14.21648082
4SMG14.01383838
5CDC73.79753373
6WEE13.49273800
7SIK13.04419677
8ICK2.81733080
9VRK12.52870901
10SRPK12.51661019
11CCNB12.48384448
12ZAK2.30714977
13VRK22.29531603
14EIF2AK12.26356275
15NEK22.25995953
16TLK12.23870047
17PRPF4B2.20938933
18BRSK22.17698642
19TTK2.12099351
20PLK42.10577267
21PASK2.04835737
22PLK12.02659991
23ERN11.98397844
24ACVR1B1.92975817
25ATR1.92539737
26MAP3K101.91285327
27CDK71.89724542
28IRAK31.83394141
29TSSK61.83191073
30TTN1.75194531
31PRKD31.73836650
32LMTK21.66264398
33MKNK11.65562405
34CDK121.64007597
35CDK81.63097438
36EIF2AK31.60686520
37PKN21.59697109
38NEK11.57937197
39NME21.57793735
40BRSK11.55392224
41GRK11.50049795
42FGFR41.50003563
43AURKB1.46367555
44CHEK21.40404510
45NTRK11.39719055
46PLK31.38227973
47PTK21.37917295
48TGFBR11.34821478
49PDGFRA1.31870471
50BMX1.31024755
51LIMK11.30262086
52RIPK11.26679369
53KDR1.26552433
54BRD41.24169994
55LATS21.23428640
56TXK1.20787937
57ARAF1.20631662
58MTOR1.16587001
59MKNK21.12821480
60AURKA1.11688293
61DYRK31.09010091
62RPS6KB21.06646312
63AKT31.05457406
64CHEK11.02810584
65PTK61.02180157
66EIF2AK20.99309152
67STK38L0.98623308
68MST1R0.98087434
69MAP4K10.97820783
70SIK20.91329479
71CDK40.89726896
72KSR20.89347699
73TYRO30.88807928
74ATM0.88455621
75MUSK0.83059403
76MAP2K20.81333771
77MARK20.80938868
78MET0.79305627
79BRAF0.78704536
80STK40.78654956
81TESK10.78641126
82PAK60.78388183
83ILK0.75223894
84MAP3K90.75014613
85MAP3K110.74829669
86EPHB10.74188510
87PAK40.74121174
88BTK0.73957519
89CDK11A0.73325397
90RPS6KA40.71799093
91LRRK20.70963389
92BMPR1B0.69719137
93CDK20.69347698
94STK100.69317742
95CDK150.68595937
96PIM10.68321762
97RPS6KA20.68297359
98CSNK2A10.65762564
99MAP3K80.65203277
100CDK180.63882953
101MAP2K30.62707636
102KIT0.62648832
103IRAK40.62647631
104FLT30.62375351
105PAK20.62288460
106MAP2K60.61532749
107SIK30.60187357
108CLK10.58447861
109CDK10.57093612
110SCYL20.57089132
111RPS6KA50.56872893
112DAPK10.55889245
113CDK140.55841038
114PRKCI0.55648750
115EPHA20.54819495
116HIPK20.53969242
117TESK20.53130050
118PIM20.52252302
119OBSCN0.51587210
120TEC0.50948679
121CDK190.49763933
122CSNK2A20.49294587
123PDPK10.49228190
124PAK10.49139181
125CDK30.46983854
126CAMKK10.45288700
127EEF2K0.45197295
128UHMK10.44023316
129ALK0.43928355
130MYLK0.43625416
131MAPK110.43476082
132MAP3K10.42738224
133TAOK20.41438083
134STK380.41315288
135PRKG20.40597148
136ERBB40.39512032
137BCKDK0.39288745
138IRAK20.37741892
139CDC42BPA0.37534244
140MELK0.36524492
141JAK30.36465616
142PDK30.35757204
143PDK40.35757204
144DYRK1B0.35681549
145NEK60.35570935
146YES10.35313456
147EPHB20.35179178
148MAPKAPK30.33796614
149RPS6KC10.32994631
150RPS6KL10.32994631
151RPS6KB10.32188423
152RPS6KA60.31904586
153ADRBK20.28862290
154CHUK0.27828229
155CDK90.27441667
156DYRK20.27101962
157AKT20.25966675
158STK240.25879234
159PRKD20.25830149
160NME10.24365049
161LYN0.24348108

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.15615779
2Mismatch repair_Homo sapiens_hsa034304.45758741
3Homologous recombination_Homo sapiens_hsa034403.56426135
4Base excision repair_Homo sapiens_hsa034103.53003964
5RNA polymerase_Homo sapiens_hsa030203.23753630
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10789368
7Fanconi anemia pathway_Homo sapiens_hsa034603.01864545
8Spliceosome_Homo sapiens_hsa030403.01637662
9Nucleotide excision repair_Homo sapiens_hsa034203.00415400
10Cell cycle_Homo sapiens_hsa041102.81226093
11Proteasome_Homo sapiens_hsa030502.73327488
12RNA transport_Homo sapiens_hsa030132.64883465
13Pyrimidine metabolism_Homo sapiens_hsa002402.63135494
14Ribosome_Homo sapiens_hsa030102.62180530
15Non-homologous end-joining_Homo sapiens_hsa034502.37552512
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.29823376
17RNA degradation_Homo sapiens_hsa030182.17550809
18Central carbon metabolism in cancer_Homo sapiens_hsa052302.16826068
19* Basal transcription factors_Homo sapiens_hsa030222.14604267
20One carbon pool by folate_Homo sapiens_hsa006702.00652585
21mRNA surveillance pathway_Homo sapiens_hsa030151.90330724
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.86285802
23Chronic myeloid leukemia_Homo sapiens_hsa052201.77679482
24Bladder cancer_Homo sapiens_hsa052191.63694404
25p53 signaling pathway_Homo sapiens_hsa041151.60094333
26Purine metabolism_Homo sapiens_hsa002301.59193508
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.55643436
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53494918
29Endometrial cancer_Homo sapiens_hsa052131.48524077
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.47797870
31Non-small cell lung cancer_Homo sapiens_hsa052231.43297036
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33974300
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32285134
34Acute myeloid leukemia_Homo sapiens_hsa052211.28918431
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26908974
36Glioma_Homo sapiens_hsa052141.26494612
37VEGF signaling pathway_Homo sapiens_hsa043701.24349347
38Primary immunodeficiency_Homo sapiens_hsa053401.21531147
39Vibrio cholerae infection_Homo sapiens_hsa051101.13541448
40Insulin signaling pathway_Homo sapiens_hsa049101.13523525
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10461033
42Epstein-Barr virus infection_Homo sapiens_hsa051691.05856291
43ErbB signaling pathway_Homo sapiens_hsa040121.04161349
44Pancreatic cancer_Homo sapiens_hsa052121.04106320
45AMPK signaling pathway_Homo sapiens_hsa041521.01878050
46Focal adhesion_Homo sapiens_hsa045101.00016476
47Synaptic vesicle cycle_Homo sapiens_hsa047210.99943370
48Adherens junction_Homo sapiens_hsa045200.99186405
49Prion diseases_Homo sapiens_hsa050200.98598851
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98219254
51Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95414150
52* Herpes simplex infection_Homo sapiens_hsa051680.94613375
53Melanogenesis_Homo sapiens_hsa049160.93625826
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93569457
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.91719046
56Protein export_Homo sapiens_hsa030600.87201300
57mTOR signaling pathway_Homo sapiens_hsa041500.86333264
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85991579
59Proteoglycans in cancer_Homo sapiens_hsa052050.85433718
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.84664172
61Systemic lupus erythematosus_Homo sapiens_hsa053220.82855917
62Oocyte meiosis_Homo sapiens_hsa041140.82671947
63Renal cell carcinoma_Homo sapiens_hsa052110.81518522
64Prostate cancer_Homo sapiens_hsa052150.80541746
65ECM-receptor interaction_Homo sapiens_hsa045120.79532865
66Antigen processing and presentation_Homo sapiens_hsa046120.79277723
67Folate biosynthesis_Homo sapiens_hsa007900.77617348
68Axon guidance_Homo sapiens_hsa043600.76448531
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75274159
70HTLV-I infection_Homo sapiens_hsa051660.74603382
71N-Glycan biosynthesis_Homo sapiens_hsa005100.74415961
72Viral carcinogenesis_Homo sapiens_hsa052030.73892622
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72487577
74Endocytosis_Homo sapiens_hsa041440.71689833
75Estrogen signaling pathway_Homo sapiens_hsa049150.71505574
76Huntingtons disease_Homo sapiens_hsa050160.67770976
77Tight junction_Homo sapiens_hsa045300.67237548
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65170084
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64943616
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.64528074
81Fructose and mannose metabolism_Homo sapiens_hsa000510.64513796
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63571607
83Glucagon signaling pathway_Homo sapiens_hsa049220.62718660
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62578994
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61332200
86Inositol phosphate metabolism_Homo sapiens_hsa005620.60542776
87Selenocompound metabolism_Homo sapiens_hsa004500.59371052
88Basal cell carcinoma_Homo sapiens_hsa052170.57433772
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.57263679
90Melanoma_Homo sapiens_hsa052180.57229500
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56476019
92Choline metabolism in cancer_Homo sapiens_hsa052310.56213463
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55853318
94GnRH signaling pathway_Homo sapiens_hsa049120.55754063
95Long-term potentiation_Homo sapiens_hsa047200.55056775
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55042562
97Notch signaling pathway_Homo sapiens_hsa043300.54901295
98Galactose metabolism_Homo sapiens_hsa000520.54065455
99Gap junction_Homo sapiens_hsa045400.52995616
100Measles_Homo sapiens_hsa051620.52671246
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52051573
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50680685
103Dilated cardiomyopathy_Homo sapiens_hsa054140.49229136
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49157126
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48989635
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.48442420
107Pentose phosphate pathway_Homo sapiens_hsa000300.47941242
108Vitamin B6 metabolism_Homo sapiens_hsa007500.47684019
109Biosynthesis of amino acids_Homo sapiens_hsa012300.47087517
110Parkinsons disease_Homo sapiens_hsa050120.46625745
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.45426450
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43246808
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.41819704
114Legionellosis_Homo sapiens_hsa051340.41491795
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39963609
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.37014683
117Arachidonic acid metabolism_Homo sapiens_hsa005900.36467109
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35387605
119Apoptosis_Homo sapiens_hsa042100.33666607
120Sulfur relay system_Homo sapiens_hsa041220.33152202
121Hematopoietic cell lineage_Homo sapiens_hsa046400.32533530
122Hippo signaling pathway_Homo sapiens_hsa043900.32247491
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32193621
124MicroRNAs in cancer_Homo sapiens_hsa052060.32060815
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31228685
126Alcoholism_Homo sapiens_hsa050340.31225459
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30685253
128Thyroid cancer_Homo sapiens_hsa052160.27847480
129Glutathione metabolism_Homo sapiens_hsa004800.27707912
130Metabolic pathways_Homo sapiens_hsa011000.27498864
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26624073
132Other glycan degradation_Homo sapiens_hsa005110.26446318
133Allograft rejection_Homo sapiens_hsa053300.25259057
134Hedgehog signaling pathway_Homo sapiens_hsa043400.25243079
135Hepatitis B_Homo sapiens_hsa051610.24968978
136Carbon metabolism_Homo sapiens_hsa012000.24923059
137Oxidative phosphorylation_Homo sapiens_hsa001900.24809238
138Influenza A_Homo sapiens_hsa051640.24456710
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24091242
140Autoimmune thyroid disease_Homo sapiens_hsa053200.22736263
141Regulation of autophagy_Homo sapiens_hsa041400.22141644
142Small cell lung cancer_Homo sapiens_hsa052220.22092219
143Wnt signaling pathway_Homo sapiens_hsa043100.21707047
144Circadian rhythm_Homo sapiens_hsa047100.21705532
145Pathways in cancer_Homo sapiens_hsa052000.20909045
146SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18642773
147Colorectal cancer_Homo sapiens_hsa052100.18168237
148TGF-beta signaling pathway_Homo sapiens_hsa043500.17780108
149Viral myocarditis_Homo sapiens_hsa054160.14881070
150Lysine degradation_Homo sapiens_hsa003100.14080830
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13833772
152Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.13448607
153Maturity onset diabetes of the young_Homo sapiens_hsa049500.11984378
154HIF-1 signaling pathway_Homo sapiens_hsa040660.11929833
155Shigellosis_Homo sapiens_hsa051310.11648473

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »