TAF6L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.59259984
2proline biosynthetic process (GO:0006561)5.72728330
3DNA deamination (GO:0045006)5.43098729
4viral transcription (GO:0019083)5.34899104
5translational termination (GO:0006415)5.11112505
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.93709750
7regulation of mammary gland epithelial cell proliferation (GO:0033599)4.86287288
8ribosomal small subunit biogenesis (GO:0042274)4.84170191
9cotranslational protein targeting to membrane (GO:0006613)4.81893981
10protein targeting to ER (GO:0045047)4.80616331
11negative regulation of erythrocyte differentiation (GO:0045647)4.68031258
12establishment of protein localization to endoplasmic reticulum (GO:0072599)4.55063860
13protein localization to endoplasmic reticulum (GO:0070972)4.54524914
14snRNA metabolic process (GO:0016073)4.48716428
15translational elongation (GO:0006414)4.48433169
16peptidyl-arginine omega-N-methylation (GO:0035247)4.41158364
17negative regulation of cell size (GO:0045792)4.26426692
18Golgi transport vesicle coating (GO:0048200)4.25562993
19COPI coating of Golgi vesicle (GO:0048205)4.25562993
20maturation of SSU-rRNA (GO:0030490)4.08801609
21telomere maintenance via semi-conservative replication (GO:0032201)4.06317426
22viral life cycle (GO:0019058)4.04893002
23snRNA processing (GO:0016180)4.00460924
24apoptotic process involved in morphogenesis (GO:0060561)4.00300820
25proline metabolic process (GO:0006560)3.92636286
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.90897215
27spliceosomal tri-snRNP complex assembly (GO:0000244)3.89269575
28cellular protein complex disassembly (GO:0043624)3.84510093
29DNA strand elongation involved in DNA replication (GO:0006271)3.82642997
30translational initiation (GO:0006413)3.80839221
31modulation by virus of host process (GO:0019054)3.66672112
32mannose metabolic process (GO:0006013)3.64290603
33DNA strand elongation (GO:0022616)3.64245910
34GDP-mannose metabolic process (GO:0019673)3.63647412
35retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.62443696
36telomere maintenance via recombination (GO:0000722)3.61735993
37negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.61088315
38histone arginine methylation (GO:0034969)3.60186773
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.54227338
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.53483294
41modulation by symbiont of host cellular process (GO:0044068)3.53314361
42regulation of chromatin binding (GO:0035561)3.52190366
43ribosomal large subunit biogenesis (GO:0042273)3.50546915
44pentose-phosphate shunt (GO:0006098)3.45174069
45semaphorin-plexin signaling pathway (GO:0071526)3.43435699
46peptidyl-arginine methylation (GO:0018216)3.42636846
47peptidyl-arginine N-methylation (GO:0035246)3.42636846
48planar cell polarity pathway involved in neural tube closure (GO:0090179)3.40646510
49protein retention in ER lumen (GO:0006621)3.38451355
50protein complex disassembly (GO:0043241)3.35334841
51protein-DNA complex disassembly (GO:0032986)3.33410676
52nucleosome disassembly (GO:0006337)3.33410676
53intracellular estrogen receptor signaling pathway (GO:0030520)3.31773691
54UV protection (GO:0009650)3.30269456
55translation (GO:0006412)3.29868156
56mitotic recombination (GO:0006312)3.28213122
57adherens junction assembly (GO:0034333)3.27337696
58proteasome assembly (GO:0043248)3.27198645
59protein localization to endosome (GO:0036010)3.25739498
60epithelial cell differentiation involved in prostate gland development (GO:0060742)3.24965106
61protein insertion into membrane (GO:0051205)3.23935902
62DNA replication initiation (GO:0006270)3.19809774
63focal adhesion assembly (GO:0048041)3.17751110
64cell-substrate adherens junction assembly (GO:0007045)3.17751110
65macromolecular complex disassembly (GO:0032984)3.17001546
66regulation of translational fidelity (GO:0006450)3.14824135
67protein targeting to membrane (GO:0006612)3.14333804
68regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.12990080
69glucose catabolic process (GO:0006007)3.11612546
70maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.10473545
71activation of Rac GTPase activity (GO:0032863)3.10411628
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.06777596
73antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.06777596
74mitotic chromosome condensation (GO:0007076)3.03332878
753-UTR-mediated mRNA stabilization (GO:0070935)3.03049612
76positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.03023898
77nuclear-transcribed mRNA catabolic process (GO:0000956)3.02043730
78regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.02012714
79regulation of early endosome to late endosome transport (GO:2000641)3.00368507
80nuclear envelope reassembly (GO:0031468)2.98490427
81mitotic nuclear envelope reassembly (GO:0007084)2.98490427
82negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.96794080
83signal peptide processing (GO:0006465)2.95854907
84telomere maintenance via telomere lengthening (GO:0010833)2.93415855
85regulation of glucose import in response to insulin stimulus (GO:2001273)2.92276581
86cellular response to virus (GO:0098586)2.92154942
87ribonucleoprotein complex biogenesis (GO:0022613)2.92033891
88adenine nucleotide transport (GO:0051503)2.90654069
89mRNA catabolic process (GO:0006402)2.90331520
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.88098352
91NADPH regeneration (GO:0006740)2.86402729
92antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.85616420
93nucleotide-excision repair, DNA gap filling (GO:0006297)2.83644793
94folic acid metabolic process (GO:0046655)2.83422946
95maternal placenta development (GO:0001893)2.83172357
96RNA catabolic process (GO:0006401)2.78977992
97modulation by virus of host morphology or physiology (GO:0019048)2.78513437
98regulation of NFAT protein import into nucleus (GO:0051532)2.77470208
99NIK/NF-kappaB signaling (GO:0038061)2.77294929
100neutrophil activation involved in immune response (GO:0002283)2.76870400
101formation of translation preinitiation complex (GO:0001731)2.74883976
102response to interferon-beta (GO:0035456)2.73849344
103positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.73007555
104antigen processing and presentation of endogenous antigen (GO:0019883)2.70358143
105DNA replication checkpoint (GO:0000076)2.69135670
106urea cycle (GO:0000050)2.66431373
107activation of MAPKKK activity (GO:0000185)2.65460849
108regulation of cholesterol biosynthetic process (GO:0045540)2.65172883
109pentose metabolic process (GO:0019321)2.64141296
110regulation of histone H3-K27 methylation (GO:0061085)2.62721812
111negative regulation of viral release from host cell (GO:1902187)2.62306930
112activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.62069038
113embryonic process involved in female pregnancy (GO:0060136)2.60150723
114mRNA stabilization (GO:0048255)2.59855251
115RNA stabilization (GO:0043489)2.59855251
116glutamine family amino acid biosynthetic process (GO:0009084)2.59515541
117Arp2/3 complex-mediated actin nucleation (GO:0034314)2.58769250
118DNA unwinding involved in DNA replication (GO:0006268)2.57788686
119positive regulation of nuclease activity (GO:0032075)2.57485727
120leukocyte aggregation (GO:0070486)2.57199524
121immunoglobulin mediated immune response (GO:0016064)2.57113912
122adenosine receptor signaling pathway (GO:0001973)2.57089605
123rRNA transcription (GO:0009303)2.56510978
124heterochromatin organization (GO:0070828)2.55600960
125cellular response to interferon-beta (GO:0035458)2.55553901
126rRNA processing (GO:0006364)2.55114673
127L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55110187
128exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53317624
129stress fiber assembly (GO:0043149)2.53208743
130protein complex localization (GO:0031503)2.53164382
131regulation of protein heterodimerization activity (GO:0043497)2.52362241
132activation of JUN kinase activity (GO:0007257)2.52065728
133L-serine metabolic process (GO:0006563)2.51575291
134regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.51417645
135apoptotic process involved in development (GO:1902742)2.51180261
136NADH metabolic process (GO:0006734)2.50852305
137negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.49991360
138negative regulation of fatty acid biosynthetic process (GO:0045717)2.49644988
139barbed-end actin filament capping (GO:0051016)2.49188602
140pseudouridine synthesis (GO:0001522)2.49168720
141CENP-A containing nucleosome assembly (GO:0034080)2.49114326
142tricarboxylic acid metabolic process (GO:0072350)2.48810132
143negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.47425196
144negative regulation of myotube differentiation (GO:0010832)2.46901451
145glucose 6-phosphate metabolic process (GO:0051156)2.46839920
146cell-cell junction maintenance (GO:0045217)2.46823008
147regulation of cholesterol metabolic process (GO:0090181)2.46778938
148positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.46621708
149rRNA metabolic process (GO:0016072)2.46448420
150mitochondrial fusion (GO:0008053)2.46399054
151monosaccharide biosynthetic process (GO:0046364)2.46267004
152regulation of type I interferon-mediated signaling pathway (GO:0060338)2.45676849
153DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.45253379
154positive regulation of B cell differentiation (GO:0045579)2.44767105
155nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.44368365
156endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.44328315
157purine ribonucleotide transport (GO:0015868)2.43268925
158signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.42958780
159intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.42958780
160pinocytosis (GO:0006907)2.42464790
161signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.40756429
162signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.40756429
163signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.40756429
164DNA duplex unwinding (GO:0032508)2.40611597
165iron-sulfur cluster assembly (GO:0016226)2.39816382
166metallo-sulfur cluster assembly (GO:0031163)2.39816382
167pteridine-containing compound biosynthetic process (GO:0042559)2.39630412
168basement membrane organization (GO:0071711)2.39524539
169B cell mediated immunity (GO:0019724)2.39479339
170telomere organization (GO:0032200)2.38709234
171telomere maintenance (GO:0000723)2.38240453
172chromatin remodeling at centromere (GO:0031055)2.36858290
173transcription-coupled nucleotide-excision repair (GO:0006283)2.35432920
174cellular component biogenesis (GO:0044085)2.35146644
175transcription elongation from RNA polymerase III promoter (GO:0006385)2.34587037
176termination of RNA polymerase III transcription (GO:0006386)2.34587037
177regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.34327037
178positive regulation of gamma-delta T cell activation (GO:0046645)2.33219781
179signal transduction involved in DNA integrity checkpoint (GO:0072401)2.32070120
180signal transduction involved in DNA damage checkpoint (GO:0072422)2.32070120
181platelet dense granule organization (GO:0060155)2.30741178
182T cell apoptotic process (GO:0070231)2.30164358
183negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.30041245
184negative regulation of ligase activity (GO:0051352)2.30041245
185somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.29021820
186somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.29021820
187isotype switching (GO:0045190)2.29021820
188respiratory burst (GO:0045730)2.28994069
189antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.28775701
190heme biosynthetic process (GO:0006783)2.28716994
191positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.27466153
192regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.27096314
193signal transduction involved in cell cycle checkpoint (GO:0072395)2.26507582
194positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.25837558
195pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.25376348
196deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.24806302
197defense response to protozoan (GO:0042832)2.23582037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.79805826
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34090838
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.18248822
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09136633
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.89587532
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.79971677
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77659523
8LXR_22292898_ChIP-Seq_THP-1_Human2.72603360
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65025449
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.63878882
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.62110121
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.56361012
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.46051702
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35352210
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.34579183
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.33468811
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.27939922
18TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.24918224
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23566545
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.22651456
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22556494
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21182408
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.20654709
24VDR_23849224_ChIP-Seq_CD4+_Human2.19245859
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16763737
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.12155706
27KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08238443
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06720822
29RACK7_27058665_Chip-Seq_MCF-7_Human2.04986813
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03199196
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99973868
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.98230648
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97531323
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97136704
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.95757144
36XRN2_22483619_ChIP-Seq_HELA_Human1.92720835
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92541534
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92472291
39P68_20966046_ChIP-Seq_HELA_Human1.90250905
40KDM2B_26808549_Chip-Seq_DND41_Human1.88865469
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88304624
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.88016926
43FOXP3_21729870_ChIP-Seq_TREG_Human1.87042983
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.84679079
45TCF7_22412390_ChIP-Seq_EML_Mouse1.81642189
46* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79847620
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77358675
48* SPI1_23547873_ChIP-Seq_NB4_Human1.76613155
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.76536607
50DCP1A_22483619_ChIP-Seq_HELA_Human1.76370358
51ZNF263_19887448_ChIP-Seq_K562_Human1.74232717
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73875179
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72934474
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.72656095
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69403348
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.69357226
57* SRF_21415370_ChIP-Seq_HL-1_Mouse1.69054092
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66379245
59VDR_21846776_ChIP-Seq_THP-1_Human1.65448407
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64646221
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64311428
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61281499
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.60983934
64* GABP_19822575_ChIP-Seq_HepG2_Human1.60377441
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60327169
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.60101148
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.58362684
68GATA1_22025678_ChIP-Seq_K562_Human1.57668863
69ELK1_19687146_ChIP-ChIP_HELA_Human1.57016996
70SCL_19346495_ChIP-Seq_HPC-7_Human1.56967251
71* SA1_27219007_Chip-Seq_ERYTHROID_Human1.52925453
72TTF2_22483619_ChIP-Seq_HELA_Human1.48878563
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48501205
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.47498109
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46004713
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45798259
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43740105
78KDM2B_26808549_Chip-Seq_K562_Human1.42929864
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.42583738
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42377901
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42117946
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.40753617
83SMC4_20622854_ChIP-Seq_HELA_Human1.38812480
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38351789
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38234413
86MYC_22102868_ChIP-Seq_BL_Human1.38162096
87* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36386752
88* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34508758
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34284074
90* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34244875
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34195672
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.33344334
93E2F1_21310950_ChIP-Seq_MCF-7_Human1.33256574
94GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32516086
95BCOR_27268052_Chip-Seq_Bcells_Human1.32057729
96* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31956341
97CREB1_26743006_Chip-Seq_LNCaP_Human1.31152196
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31078122
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30905454
100CIITA_25753668_ChIP-Seq_RAJI_Human1.30614351
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28967530
102SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28472667
103NCOR1_26117541_ChIP-Seq_K562_Human1.27174558
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25620470
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25535496
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.24257041
107MYB_26560356_Chip-Seq_TH2_Human1.23306677
108BCL6_27268052_Chip-Seq_Bcells_Human1.22861189
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22679350
110KDM2B_26808549_Chip-Seq_JURKAT_Human1.22227484
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21805005
112RUNX1_22412390_ChIP-Seq_EML_Mouse1.21005183
113BP1_19119308_ChIP-ChIP_Hs578T_Human1.20692001
114ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20619952
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19844848
116NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19018696
117VDR_24763502_ChIP-Seq_THP-1_Human1.18508732
118MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.18247083
119MAF_26560356_Chip-Seq_TH1_Human1.18072012
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17235703
121* CTCF_21964334_Chip-Seq_Bcells_Human1.16933968
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16887977
123POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16681722
124* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15319621
125P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15306877
126KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14862390
127* TFEB_21752829_ChIP-Seq_HELA_Human1.14615049
128NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14450356
129* RARA_24833708_ChIP-Seq_LIVER_Mouse1.13719523
130ATF3_27146783_Chip-Seq_COLON_Human1.13567234
131DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12724701
132CTCF_26484167_Chip-Seq_Bcells_Mouse1.12615713
133PHF8_20622854_ChIP-Seq_HELA_Human1.12448938
134GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11431867
135PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11425213
136IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10952287
137* FOXP1_21924763_ChIP-Seq_HESCs_Human1.10635110
138TP53_22127205_ChIP-Seq_IMR90_Human1.10406730
139PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09813667
140ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09777341
141CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09236864
142TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09134545
143RARB_24833708_ChIP-Seq_LIVER_Mouse1.09134305
144FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08979446
145SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08743631
146IRF8_27001747_Chip-Seq_BMDM_Mouse1.08723505
147DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08157931
148BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07911168
149CTCF_27219007_Chip-Seq_Bcells_Human1.07778272
150TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07773182
151MYB_26560356_Chip-Seq_TH1_Human1.07680692
152* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07596782
153MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07083763
154TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07025812
155SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06980807
156ETS1_21867929_ChIP-Seq_TH2_Mouse1.06793097
157MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06768196
158BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06615123
159LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05223544
160LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04128144
161CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03515654
162KDM5A_27292631_Chip-Seq_BREAST_Human1.02295797
163ELK1_22589737_ChIP-Seq_MCF10A_Human1.01139174
164UTX_26944678_Chip-Seq_JUKART_Human1.00988734
165AR_21909140_ChIP-Seq_LNCAP_Human0.99209845
166E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98385268
167FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97803191
168HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97649823
169MAF_26560356_Chip-Seq_TH2_Human0.93250638

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.23808290
2MP0005451_abnormal_body_composition4.04135744
3MP0001835_abnormal_antigen_presentation3.35735835
4MP0005076_abnormal_cell_differentiation3.12420751
5MP0003693_abnormal_embryo_hatching3.10400134
6MP0004185_abnormal_adipocyte_glucose2.76164272
7MP0005671_abnormal_response_to2.73173491
8MP0009785_altered_susceptibility_to2.63035655
9MP0000685_abnormal_immune_system2.56861328
10MP0008260_abnormal_autophagy2.50289155
11MP0002396_abnormal_hematopoietic_system2.45935068
12MP0003303_peritoneal_inflammation2.43930035
13MP0000751_myopathy2.42516479
14MP0004233_abnormal_muscle_weight2.36216395
15MP0001849_ear_inflammation2.34202378
16MP0003436_decreased_susceptibility_to2.32777426
17MP0005000_abnormal_immune_tolerance2.28920972
18MP0004858_abnormal_nervous_system2.26506235
19MP0003763_abnormal_thymus_physiology2.21784134
20MP0005025_abnormal_response_to2.21189676
21MP0002148_abnormal_hypersensitivity_rea2.20033504
22MP0009333_abnormal_splenocyte_physiolog2.19422823
23MP0003453_abnormal_keratinocyte_physiol2.14076882
24MP0001800_abnormal_humoral_immune2.12165185
25MP0004957_abnormal_blastocyst_morpholog2.09866284
26MP0002452_abnormal_antigen_presenting2.08322991
27MP0000490_abnormal_crypts_of2.07445791
28MP0002723_abnormal_immune_serum2.04434502
29MP0003724_increased_susceptibility_to2.03017518
30MP0010094_abnormal_chromosome_stability2.00646440
31MP0002420_abnormal_adaptive_immunity1.98167987
32MP0002419_abnormal_innate_immunity1.98053833
33MP0001819_abnormal_immune_cell1.96318110
34MP0001790_abnormal_immune_system1.95516874
35MP0005387_immune_system_phenotype1.95516874
36MP0002398_abnormal_bone_marrow1.94099574
37MP0000747_muscle_weakness1.91293530
38MP0003077_abnormal_cell_cycle1.91140297
39MP0008058_abnormal_DNA_repair1.86914432
40MP0008057_abnormal_DNA_replication1.82209866
41MP0005501_abnormal_skin_physiology1.81670094
42MP0001853_heart_inflammation1.81038583
43MP0002166_altered_tumor_susceptibility1.79930810
44MP0002405_respiratory_system_inflammati1.77948574
45MP0003186_abnormal_redox_activity1.77934718
46MP0005171_absent_coat_pigmentation1.74770659
47MP0006054_spinal_hemorrhage1.73257173
48MP0000003_abnormal_adipose_tissue1.73226752
49MP0000716_abnormal_immune_system1.72655079
50MP0000689_abnormal_spleen_morphology1.72430550
51MP0003111_abnormal_nucleus_morphology1.72342041
52MP0001545_abnormal_hematopoietic_system1.72162577
53MP0005397_hematopoietic_system_phenotyp1.72162577
54MP0010155_abnormal_intestine_physiology1.71378888
55MP0005666_abnormal_adipose_tissue1.70371464
56MP0002722_abnormal_immune_system1.69974335
57MP0005464_abnormal_platelet_physiology1.67858588
58MP0008007_abnormal_cellular_replicative1.65533357
59MP0010234_abnormal_vibrissa_follicle1.64224838
60MP0002429_abnormal_blood_cell1.61432117
61MP0002089_abnormal_postnatal_growth/wei1.55128522
62MP0005174_abnormal_tail_pigmentation1.54540174
63MP0005075_abnormal_melanosome_morpholog1.53824527
64MP0005375_adipose_tissue_phenotype1.51453622
65MP0002249_abnormal_larynx_morphology1.51371148
66MP0002006_tumorigenesis1.49499854
67MP0002132_abnormal_respiratory_system1.47705903
68MP0000750_abnormal_muscle_regeneration1.47528775
69MP0005058_abnormal_lysosome_morphology1.46395153
70MP0000858_altered_metastatic_potential1.46230419
71MP0001346_abnormal_lacrimal_gland1.45142813
72MP0000465_gastrointestinal_hemorrhage1.44490108
73MP0001845_abnormal_inflammatory_respons1.44430653
74MP0003656_abnormal_erythrocyte_physiolo1.42760486
75MP0000733_abnormal_muscle_development1.42675917
76MP0010030_abnormal_orbit_morphology1.42065442
77MP0002796_impaired_skin_barrier1.41771591
78MP0004808_abnormal_hematopoietic_stem1.41178323
79MP0010352_gastrointestinal_tract_polyps1.41037057
80MP0001873_stomach_inflammation1.40138751
81MP0009379_abnormal_foot_pigmentation1.37824349
82MP0006082_CNS_inflammation1.37528093
83MP0005409_darkened_coat_color1.35819425
84MP0005257_abnormal_intraocular_pressure1.35224972
85MP0004147_increased_porphyrin_level1.34883785
86MP0000759_abnormal_skeletal_muscle1.34780285
87MP0000703_abnormal_thymus_morphology1.34441324
88MP0000537_abnormal_urethra_morphology1.33280607
89MP0001348_abnormal_lacrimal_gland1.33093023
90MP0001730_embryonic_growth_arrest1.32597597
91MP0000678_abnormal_parathyroid_gland1.32104114
92MP0003866_abnormal_defecation1.29143247
93MP0008469_abnormal_protein_level1.26766392
94MP0002019_abnormal_tumor_incidence1.26164656
95MP0008932_abnormal_embryonic_tissue1.22397931
96MP0009672_abnormal_birth_weight1.20777541
97MP0005330_cardiomyopathy1.19683672
98MP0002254_reproductive_system_inflammat1.18966648
99MP0004947_skin_inflammation1.18929069
100MP0001661_extended_life_span1.17613618
101MP0003806_abnormal_nucleotide_metabolis1.17271096
102MP0004087_abnormal_muscle_fiber1.16538547
103MP0003566_abnormal_cell_adhesion1.13494233
104MP0003091_abnormal_cell_migration1.11606473
105MP0000313_abnormal_cell_death1.11159923
106MP0001533_abnormal_skeleton_physiology1.10881029
107MP0002933_joint_inflammation1.10376886
108MP0002080_prenatal_lethality1.08232267
109MP0003329_amyloid_beta_deposits1.07158946
110MP0002095_abnormal_skin_pigmentation1.04550516
111MP0004130_abnormal_muscle_cell1.01160573
112MP0009931_abnormal_skin_appearance1.00057399
113MP0005621_abnormal_cell_physiology0.98730028
114MP0003786_premature_aging0.98617508
115MP0004510_myositis0.95022236
116MP0005083_abnormal_biliary_tract0.93383638
117MP0005310_abnormal_salivary_gland0.92740849
118MP0003221_abnormal_cardiomyocyte_apopto0.90214157
119MP0010630_abnormal_cardiac_muscle0.88054306
120MP0005623_abnormal_meninges_morphology0.87878754
121MP0000681_abnormal_thyroid_gland0.86703559
122MP0003300_gastrointestinal_ulcer0.85074343
123MP0010307_abnormal_tumor_latency0.84321558
124MP0000343_altered_response_to0.83231316
125MP0000350_abnormal_cell_proliferation0.82661703
126MP0002060_abnormal_skin_morphology0.81832537
127MP0000015_abnormal_ear_pigmentation0.81579938
128MP0003448_altered_tumor_morphology0.80352142
129MP0001216_abnormal_epidermal_layer0.79816975
130MP0001986_abnormal_taste_sensitivity0.79463394
131MP0009764_decreased_sensitivity_to0.79453322
132MP0003191_abnormal_cellular_cholesterol0.78800951
133MP0005380_embryogenesis_phenotype0.78249379
134MP0001672_abnormal_embryogenesis/_devel0.78249379
135MP0009840_abnormal_foam_cell0.78218602
136MP0003984_embryonic_growth_retardation0.77011205
137MP0009763_increased_sensitivity_to0.75989994
138MP0006036_abnormal_mitochondrial_physio0.73398337
139MP0000477_abnormal_intestine_morphology0.72342081
140MP0004197_abnormal_fetal_growth/weight/0.71422476
141MP0009278_abnormal_bone_marrow0.71153306
142MP0002009_preneoplasia0.71041125
143MP0002970_abnormal_white_adipose0.70953382
144MP0005384_cellular_phenotype0.70486778
145MP0004782_abnormal_surfactant_physiolog0.70390228
146MP0002086_abnormal_extraembryonic_tissu0.69658851
147MP0002098_abnormal_vibrissa_morphology0.69656681
148MP0002088_abnormal_embryonic_growth/wei0.68663139
149MP0005023_abnormal_wound_healing0.68208245
150MP0000372_irregular_coat_pigmentation0.68092965
151MP0002075_abnormal_coat/hair_pigmentati0.67925175
152MP0005379_endocrine/exocrine_gland_phen0.67264452
153MP0002269_muscular_atrophy0.66697652
154MP0003943_abnormal_hepatobiliary_system0.66501142
155MP0001764_abnormal_homeostasis0.66363858
156MP0000377_abnormal_hair_follicle0.63975097
157MP0008438_abnormal_cutaneous_collagen0.63663110
158MP0009643_abnormal_urine_homeostasis0.62472848
159MP0003634_abnormal_glial_cell0.62415735
160MP0002877_abnormal_melanocyte_morpholog0.62362757
161MP0003172_abnormal_lysosome_physiology0.61906697
162MP0002693_abnormal_pancreas_physiology0.61119412
163MP0001663_abnormal_digestive_system0.60912831
164MP0005408_hypopigmentation0.59004162
165MP0005084_abnormal_gallbladder_morpholo0.58925555
166MP0003795_abnormal_bone_structure0.58724751
167MP0004381_abnormal_hair_follicle0.58446841

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.45281512
2Abnormal number of erythroid precursors (HP:0012131)5.44793911
3Reticulocytopenia (HP:0001896)4.77613076
4Recurrent abscess formation (HP:0002722)4.40248098
5Ulnar bowing (HP:0003031)3.98684156
6Recurrent bacterial skin infections (HP:0005406)3.90110273
7Myopathic facies (HP:0002058)3.66104675
8Thrombocytosis (HP:0001894)3.56349643
9IgM deficiency (HP:0002850)3.49560076
10Aplastic anemia (HP:0001915)3.49550061
11Chronic otitis media (HP:0000389)3.37887574
12Pallor (HP:0000980)3.36544448
13Hyperacusis (HP:0010780)3.35110542
14Petechiae (HP:0000967)3.34523089
15Vacuolated lymphocytes (HP:0001922)3.29614357
16Macrocytic anemia (HP:0001972)3.26862066
17Hemorrhage of the eye (HP:0011885)3.24307515
18Type I transferrin isoform profile (HP:0003642)3.17343503
19Elevated erythrocyte sedimentation rate (HP:0003565)3.17168583
20Vertebral compression fractures (HP:0002953)3.06328614
21Abnormality of the heme biosynthetic pathway (HP:0010472)3.01952765
22Broad distal phalanx of finger (HP:0009836)2.97810674
23Turricephaly (HP:0000262)2.91771822
24Eczematoid dermatitis (HP:0000976)2.88896500
25Testicular atrophy (HP:0000029)2.85090897
26Abnormality of T cell physiology (HP:0011840)2.83115733
27Thin bony cortex (HP:0002753)2.80376414
28Achilles tendon contracture (HP:0001771)2.79956415
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.79806656
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.79806656
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.78781935
32Abnormal protein N-linked glycosylation (HP:0012347)2.78781935
33Abnormal protein glycosylation (HP:0012346)2.78781935
34Abnormal glycosylation (HP:0012345)2.78781935
35Centrally nucleated skeletal muscle fibers (HP:0003687)2.74022354
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.73941718
37Myositis (HP:0100614)2.71365182
38Pustule (HP:0200039)2.70633885
39Stridor (HP:0010307)2.67087929
40Poor head control (HP:0002421)2.65139837
41Upper limb amyotrophy (HP:0009129)2.64148290
42Distal upper limb amyotrophy (HP:0007149)2.64148290
43Exercise-induced myalgia (HP:0003738)2.60404470
44Ragged-red muscle fibers (HP:0003200)2.59746335
4511 pairs of ribs (HP:0000878)2.59343260
46Abnormality of macrophages (HP:0004311)2.57941290
47Reduced antithrombin III activity (HP:0001976)2.54249108
48Birth length less than 3rd percentile (HP:0003561)2.52235373
49Recurrent bronchitis (HP:0002837)2.52073718
50Increased connective tissue (HP:0009025)2.50748413
51Distal lower limb amyotrophy (HP:0008944)2.50347392
52Exertional dyspnea (HP:0002875)2.50032209
53Progressive muscle weakness (HP:0003323)2.47154803
54Abnormality of the Achilles tendon (HP:0005109)2.46455283
55Hepatocellular necrosis (HP:0001404)2.45598198
56Recurrent skin infections (HP:0001581)2.44490631
57Reticulocytosis (HP:0001923)2.43006960
58Hepatic necrosis (HP:0002605)2.42138439
59Abnormality of the thoracic spine (HP:0100711)2.41842513
603-Methylglutaconic aciduria (HP:0003535)2.40173352
61Oral leukoplakia (HP:0002745)2.39989551
62Abnormality of T cells (HP:0002843)2.35985786
63Biconcave vertebral bodies (HP:0004586)2.35038218
64Agnosia (HP:0010524)2.29502711
65Lymphoma (HP:0002665)2.28470742
66Distal lower limb muscle weakness (HP:0009053)2.28090443
67IgG deficiency (HP:0004315)2.27195645
68Recurrent viral infections (HP:0004429)2.26287956
69Increased hepatocellular lipid droplets (HP:0006565)2.24583666
70Difficulty climbing stairs (HP:0003551)2.24409382
71Increased cerebral lipofuscin (HP:0011813)2.23897031
72Obstructive lung disease (HP:0006536)2.19794759
73Chronic obstructive pulmonary disease (HP:0006510)2.19794759
74Long palpebral fissure (HP:0000637)2.18698664
75Poikiloderma (HP:0001029)2.17879454
76Mediastinal lymphadenopathy (HP:0100721)2.16996172
77Cholelithiasis (HP:0001081)2.12144595
78Thoracic kyphosis (HP:0002942)2.11232438
79Lipid accumulation in hepatocytes (HP:0006561)2.11126544
80Meningitis (HP:0001287)2.11013545
81Pancytopenia (HP:0001876)2.10858997
82Dysostosis multiplex (HP:0000943)2.09294569
83Insomnia (HP:0100785)2.09239691
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06253440
85Abnormality of polysaccharide metabolism (HP:0011012)2.06253440
86Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06253440
87J-shaped sella turcica (HP:0002680)2.06251124
88Recurrent fungal infections (HP:0002841)2.05181576
89Mitochondrial inheritance (HP:0001427)2.05154491
90Hypertensive crisis (HP:0100735)2.05047181
91Cervical subluxation (HP:0003308)2.05030885
92Squamous cell carcinoma (HP:0002860)2.03651802
93Mucopolysacchariduria (HP:0008155)2.02320329
94Urinary glycosaminoglycan excretion (HP:0003541)2.02320329
95Hand muscle atrophy (HP:0009130)2.01488293
96Microvesicular hepatic steatosis (HP:0001414)2.00657163
97Cerebral aneurysm (HP:0004944)1.99356712
98Bulbar palsy (HP:0001283)1.98473017
99Polygenic inheritance (HP:0010982)1.98200700
100Hepatosplenomegaly (HP:0001433)1.97938076
101Abnormality of cells of the lymphoid lineage (HP:0012140)1.97864343
102Increased neuronal autofluorescent lipopigment (HP:0002074)1.97509582
103Abnormality of reticulocytes (HP:0004312)1.97186148
104Neutropenia (HP:0001875)1.96772298
105Lymphopenia (HP:0001888)1.96436833
106Prolonged bleeding time (HP:0003010)1.96122221
107Thin ribs (HP:0000883)1.95431131
108Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.94595093
109Microretrognathia (HP:0000308)1.93613849
110Abnormal gallbladder physiology (HP:0012438)1.93304774
111Cholecystitis (HP:0001082)1.93304774
112Rough bone trabeculation (HP:0100670)1.92925345
113Bowed forearm bones (HP:0003956)1.92484156
114Bowing of the arm (HP:0006488)1.92484156
115Nasal polyposis (HP:0100582)1.91659946
116Annular pancreas (HP:0001734)1.91359202
117Increased intramyocellular lipid droplets (HP:0012240)1.90711441
118Vaginal fistula (HP:0004320)1.89970805
119Pulmonary fibrosis (HP:0002206)1.88851289
120Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88355713
121Abnormality of B cell number (HP:0010975)1.88099020
122B lymphocytopenia (HP:0010976)1.88099020
123Cellulitis (HP:0100658)1.87673463
124Epistaxis (HP:0000421)1.86819212
125Increased serum ferritin (HP:0003281)1.86146434
126Amaurosis fugax (HP:0100576)1.85927040
127Progressive external ophthalmoplegia (HP:0000590)1.85844171
128Vasculitis (HP:0002633)1.85686537
129Panhypogammaglobulinemia (HP:0003139)1.85120183
130Increased IgM level (HP:0003496)1.84936282
131Colitis (HP:0002583)1.84162636
132Joint stiffness (HP:0001387)1.84100340
133Stomatitis (HP:0010280)1.83758058
134Flat acetabular roof (HP:0003180)1.83326391
135Increased serum lactate (HP:0002151)1.82936672
136Bone marrow hypocellularity (HP:0005528)1.82500421
137Generalized aminoaciduria (HP:0002909)1.82312126
138Abnormality of the fingertips (HP:0001211)1.81330413
139Granulocytopenia (HP:0001913)1.81307298
140Pointed chin (HP:0000307)1.81009540
141Purpura (HP:0000979)1.79852939
142Easy fatigability (HP:0003388)1.79087852
143Neuronal loss in central nervous system (HP:0002529)1.78466026
144Progressive neurologic deterioration (HP:0002344)1.78304769
145Ankle clonus (HP:0011448)1.78237889
146Abnormality of glycolipid metabolism (HP:0010969)1.77976185
147Abnormality of liposaccharide metabolism (HP:0010968)1.77976185
148Abnormality of glycosphingolipid metabolism (HP:0004343)1.77976185
149Obstructive sleep apnea (HP:0002870)1.77860392
150Autoimmune hemolytic anemia (HP:0001890)1.77835663
151Renal Fanconi syndrome (HP:0001994)1.77601225
152Nuclear cataract (HP:0100018)1.77184935
153Germ cell neoplasia (HP:0100728)1.76974446
154Protrusio acetabuli (HP:0003179)1.76858451
155Recurrent pneumonia (HP:0006532)1.76581870
156Premature graying of hair (HP:0002216)1.76245296
157Rectal prolapse (HP:0002035)1.75790222
158Premature skin wrinkling (HP:0100678)1.75698283
159Gastrointestinal inflammation (HP:0004386)1.75648782
160Basal ganglia calcification (HP:0002135)1.75483786
161Recurrent gram-negative bacterial infections (HP:0005420)1.75127163
162Flared metaphyses (HP:0003015)1.75096451
163Increased CSF lactate (HP:0002490)1.74686841
164Microcytic anemia (HP:0001935)1.74442742
165Diaphragmatic weakness (HP:0009113)1.74165774
166Nausea (HP:0002018)1.73848051
167Inflammation of the large intestine (HP:0002037)1.73797522
168Colon cancer (HP:0003003)1.73575043
169Pseudobulbar signs (HP:0002200)1.73483130
170Abnormality of T cell number (HP:0011839)1.73355832
171Increased muscle lipid content (HP:0009058)1.73314014
172T lymphocytopenia (HP:0005403)1.73001134
173Loss of speech (HP:0002371)1.72484070
174Bowel incontinence (HP:0002607)1.72442560
175Back pain (HP:0003418)1.72225728
176Increased variability in muscle fiber diameter (HP:0003557)1.71875349
177Shallow orbits (HP:0000586)1.71246294
178Broad face (HP:0000283)1.70998209
179Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.70595034
180Abnormality of the gallbladder (HP:0005264)1.69685547
181Elbow flexion contracture (HP:0002987)1.69395986
182Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69038556
183External ophthalmoplegia (HP:0000544)1.69020572
184Abnormal large intestine physiology (HP:0012700)1.67730257
185Emphysema (HP:0002097)1.66619389
186Dysmetric saccades (HP:0000641)1.66398991
187Abnormal gallbladder morphology (HP:0012437)1.65489809
188Intestinal fistula (HP:0100819)1.65190886
189Spinal cord lesions (HP:0100561)1.63917369
190Syringomyelia (HP:0003396)1.63917369
191Breast hypoplasia (HP:0003187)1.63665773
192Disproportionate tall stature (HP:0001519)1.61519368
193Mitral regurgitation (HP:0001653)1.61308128
194Abnormality of skeletal muscle fiber size (HP:0012084)1.60589572
195Generalized amyotrophy (HP:0003700)1.59720304
196Choanal stenosis (HP:0000452)1.59473545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.09799648
2SMG14.24608666
3NME23.30145324
4ICK2.98844617
5SIK12.80546519
6CDK122.74706201
7PRPF4B2.67405132
8MAP4K12.54601327
9STK162.52079209
10PIM22.44534347
11EIF2AK12.40678363
12TLK12.39102845
13WEE12.29640962
14TESK22.13516589
15VRK12.10496578
16BUB12.08525355
17ACVR1B1.96780185
18TEC1.86310882
19TTN1.85006686
20BLK1.82023214
21KDR1.81783637
22KIT1.79468993
23BTK1.76853792
24IRAK31.75324792
25EIF2AK31.73682165
26IRAK41.73640187
27ZAP701.73094792
28TBK11.68226560
29FLT31.60139344
30TYK21.56211205
31DYRK31.53946199
32MAP2K31.52294544
33IKBKB1.48392905
34PASK1.46555863
35RPS6KB21.46218439
36BRSK21.45759714
37RPS6KA41.42578508
38TXK1.37702069
39CDC71.34882683
40MST41.34877698
41FGFR41.31651349
42LRRK21.31304901
43RIPK11.31196989
44MAP3K141.29904771
45IKBKE1.29846482
46JAK31.25501056
47MAP3K111.25222289
48PKN21.24785963
49VRK21.22671005
50CLK11.22546211
51STK101.21430201
52TESK11.18871895
53PIM11.18701611
54PRKD31.18308767
55MAPKAPK31.16200598
56SRPK11.15347215
57TAOK21.14123780
58ERN11.13456287
59EPHA21.10299458
60RPS6KA21.09622507
61MTOR1.09040865
62PBK1.08589206
63STK41.02634379
64CDK71.02032440
65PDPK10.98701950
66MAPK110.98265281
67CSF1R0.96979602
68PLK40.96432807
69NEK20.96231771
70RPS6KL10.95972612
71RPS6KC10.95972612
72AURKB0.94580460
73LYN0.94541803
74IRAK20.93761014
75SYK0.93516272
76RPS6KA50.92901586
77NLK0.92400234
78MAP3K100.90440647
79BCKDK0.90410208
80MAP3K30.88993095
81ATR0.88595124
82ITK0.87163151
83EIF2AK20.81568801
84BMX0.80201149
85LCK0.79969683
86BRAF0.79272027
87TGFBR20.79086275
88MAP2K20.77936159
89MAPK150.77153549
90PRKD20.75948543
91TGFBR10.75864130
92SCYL20.75613358
93PDGFRA0.74947789
94PTK60.73889173
95MAP3K80.73270747
96TAOK10.73213060
97MARK20.71144686
98MAP2K60.71131119
99MATK0.70272349
100CDK90.70177579
101PIK3CG0.69848050
102SIK20.69242504
103CCNB10.68292119
104CAMK1D0.68250723
105PLK10.67625866
106BRSK10.66507252
107MAP3K10.66289702
108CDK80.65434479
109ZAK0.65131913
110MAP3K130.64531345
111ILK0.64159605
112GRK60.63146236
113MAPKAPK50.62722482
114CDK60.61925372
115AKT20.60689132
116TNK20.59908732
117PAK40.58320366
118MKNK10.56983569
119CDK40.56638563
120MST1R0.55968130
121MAPK120.55005123
122CDK190.54362692
123CDC42BPA0.54120098
124IRAK10.52993479
125CHUK0.51908579
126EEF2K0.51613108
127KSR20.51491202
128CHEK20.49172116
129TRPM70.48249957
130NEK90.47840397
131DAPK30.47038294
132TAOK30.46914746
133RPS6KA60.46717184
134ARAF0.46337517
135PRKG20.45963070
136PDK10.45818615
137MAP3K90.45804805
138CSK0.45492637
139CSNK2A10.44173227
140AURKA0.43817646
141MAP3K120.43527310
142MAPKAPK20.42434329
143HIPK20.41558914
144MAP3K60.40940532
145RPS6KA10.40664551
146LMTK20.40661702
147MUSK0.39152201
148CDK11A0.37913666
149PAK10.37664102
150TYRO30.37588038
151BRD40.36570521
152DAPK10.35623785
153DYRK1B0.35159842
154CDK150.34595091
155MAPK40.32650858
156CHEK10.32262278
157DDR20.31313488
158PRKD10.30797092
159PTK20.30487119
160LATS20.30117433
161CDK20.28454476
162RIPK40.27136910

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.52464655
2DNA replication_Homo sapiens_hsa030304.03896623
3Mismatch repair_Homo sapiens_hsa034303.09771544
4Proteasome_Homo sapiens_hsa030502.82101620
5Protein export_Homo sapiens_hsa030602.60899027
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.57795067
7Base excision repair_Homo sapiens_hsa034102.54976677
8Homologous recombination_Homo sapiens_hsa034402.46604937
9RNA polymerase_Homo sapiens_hsa030202.31808156
10Fructose and mannose metabolism_Homo sapiens_hsa000512.22015868
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.19021616
12Biosynthesis of amino acids_Homo sapiens_hsa012302.15108670
13Pyrimidine metabolism_Homo sapiens_hsa002402.14495057
14Bladder cancer_Homo sapiens_hsa052192.11040249
15Nucleotide excision repair_Homo sapiens_hsa034202.08783187
16Spliceosome_Homo sapiens_hsa030402.04673392
17Notch signaling pathway_Homo sapiens_hsa043301.87019592
18Chronic myeloid leukemia_Homo sapiens_hsa052201.81786520
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.73536066
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73154048
21Primary immunodeficiency_Homo sapiens_hsa053401.72347926
22Non-small cell lung cancer_Homo sapiens_hsa052231.68577064
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66775600
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.65296843
25Folate biosynthesis_Homo sapiens_hsa007901.64118634
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.60873131
27Non-homologous end-joining_Homo sapiens_hsa034501.54528740
28VEGF signaling pathway_Homo sapiens_hsa043701.49706802
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48000387
30Other glycan degradation_Homo sapiens_hsa005111.46380480
31Fanconi anemia pathway_Homo sapiens_hsa034601.44768609
32Antigen processing and presentation_Homo sapiens_hsa046121.44229425
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.42880230
34One carbon pool by folate_Homo sapiens_hsa006701.41152416
35Cell cycle_Homo sapiens_hsa041101.33108725
36Carbon metabolism_Homo sapiens_hsa012001.31697648
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31213209
38Pancreatic cancer_Homo sapiens_hsa052121.30220625
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.29063198
40Legionellosis_Homo sapiens_hsa051341.28230950
41RNA transport_Homo sapiens_hsa030131.26653939
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.26563701
43Lysine degradation_Homo sapiens_hsa003101.26225975
44mTOR signaling pathway_Homo sapiens_hsa041501.25568899
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.24954920
46* Herpes simplex infection_Homo sapiens_hsa051681.23884213
47Alcoholism_Homo sapiens_hsa050341.22266657
48Leishmaniasis_Homo sapiens_hsa051401.21809012
49Systemic lupus erythematosus_Homo sapiens_hsa053221.20796989
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.19213576
51Allograft rejection_Homo sapiens_hsa053301.18631928
52RNA degradation_Homo sapiens_hsa030181.18442819
53* Basal transcription factors_Homo sapiens_hsa030221.17790714
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17129202
55Hematopoietic cell lineage_Homo sapiens_hsa046401.16676893
56Prion diseases_Homo sapiens_hsa050201.15082678
57Measles_Homo sapiens_hsa051621.14360245
58AMPK signaling pathway_Homo sapiens_hsa041521.12897580
59Endometrial cancer_Homo sapiens_hsa052131.12043743
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11460750
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10843250
62Insulin signaling pathway_Homo sapiens_hsa049101.08860192
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08824300
64p53 signaling pathway_Homo sapiens_hsa041151.06707476
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05500929
66Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03486801
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03439497
68Graft-versus-host disease_Homo sapiens_hsa053321.01676711
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01639975
70Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00375028
71N-Glycan biosynthesis_Homo sapiens_hsa005100.99633159
72Oxidative phosphorylation_Homo sapiens_hsa001900.98693764
73Parkinsons disease_Homo sapiens_hsa050120.97420952
74Purine metabolism_Homo sapiens_hsa002300.97290301
75Asthma_Homo sapiens_hsa053100.96311837
76Arginine biosynthesis_Homo sapiens_hsa002200.95951806
77Thyroid cancer_Homo sapiens_hsa052160.95673501
78Sulfur relay system_Homo sapiens_hsa041220.94547620
79Epstein-Barr virus infection_Homo sapiens_hsa051690.92911665
80Pentose phosphate pathway_Homo sapiens_hsa000300.90301620
81Apoptosis_Homo sapiens_hsa042100.88486575
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.88315575
83Glioma_Homo sapiens_hsa052140.86678344
84Phenylalanine metabolism_Homo sapiens_hsa003600.86547420
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86453474
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.85083234
87Shigellosis_Homo sapiens_hsa051310.81073758
88Malaria_Homo sapiens_hsa051440.81022049
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.80323538
90Pertussis_Homo sapiens_hsa051330.80123534
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79372023
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78767276
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78396156
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75226913
95Lysosome_Homo sapiens_hsa041420.75104593
96Hepatitis C_Homo sapiens_hsa051600.74956399
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.73868322
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73433103
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72812784
100Inositol phosphate metabolism_Homo sapiens_hsa005620.71316744
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71256648
102Huntingtons disease_Homo sapiens_hsa050160.71171748
103B cell receptor signaling pathway_Homo sapiens_hsa046620.71091412
104ErbB signaling pathway_Homo sapiens_hsa040120.70432220
105Colorectal cancer_Homo sapiens_hsa052100.69917018
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69815885
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67630463
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66619633
109MicroRNAs in cancer_Homo sapiens_hsa052060.66381757
110Renal cell carcinoma_Homo sapiens_hsa052110.66313958
111Glutathione metabolism_Homo sapiens_hsa004800.65813359
112Viral carcinogenesis_Homo sapiens_hsa052030.64751924
113Insulin resistance_Homo sapiens_hsa049310.64593231
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.63669539
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62605097
116Influenza A_Homo sapiens_hsa051640.62019861
117Prostate cancer_Homo sapiens_hsa052150.60910294
118Osteoclast differentiation_Homo sapiens_hsa043800.60034049
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59288928
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.58558700
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58332782
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57267749
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57192086
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56796808
125Pyruvate metabolism_Homo sapiens_hsa006200.55879966
126Endocytosis_Homo sapiens_hsa041440.54607167
127Arachidonic acid metabolism_Homo sapiens_hsa005900.54541260
128GnRH signaling pathway_Homo sapiens_hsa049120.53702313
129Hepatitis B_Homo sapiens_hsa051610.53483041
130Autoimmune thyroid disease_Homo sapiens_hsa053200.53424138
131Selenocompound metabolism_Homo sapiens_hsa004500.52791097
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52709422
133Glucagon signaling pathway_Homo sapiens_hsa049220.52679347
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52174932
135mRNA surveillance pathway_Homo sapiens_hsa030150.52035003
136Vitamin B6 metabolism_Homo sapiens_hsa007500.50248072
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50036839
138Sphingolipid metabolism_Homo sapiens_hsa006000.49975466
139Toxoplasmosis_Homo sapiens_hsa051450.49319549
140Tuberculosis_Homo sapiens_hsa051520.49205226
141Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47519964
142Staphylococcus aureus infection_Homo sapiens_hsa051500.46370253
143Vibrio cholerae infection_Homo sapiens_hsa051100.46274129
144Salmonella infection_Homo sapiens_hsa051320.45440641
145HTLV-I infection_Homo sapiens_hsa051660.45289444
146Alzheimers disease_Homo sapiens_hsa050100.44999926
147Sulfur metabolism_Homo sapiens_hsa009200.44941057
148Choline metabolism in cancer_Homo sapiens_hsa052310.44208409
149Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43857031
150Fatty acid metabolism_Homo sapiens_hsa012120.43794312
151T cell receptor signaling pathway_Homo sapiens_hsa046600.42653072
152Phospholipase D signaling pathway_Homo sapiens_hsa040720.42579589
153Acute myeloid leukemia_Homo sapiens_hsa052210.41461924
154Leukocyte transendothelial migration_Homo sapiens_hsa046700.40373575
155Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37806973
156TNF signaling pathway_Homo sapiens_hsa046680.37649599
157Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37137880
158Galactose metabolism_Homo sapiens_hsa000520.37116955
159Metabolic pathways_Homo sapiens_hsa011000.36658235
160Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35401176
161Small cell lung cancer_Homo sapiens_hsa052220.33852420
162Fatty acid elongation_Homo sapiens_hsa000620.31575116
163Regulation of autophagy_Homo sapiens_hsa041400.31308414
164Viral myocarditis_Homo sapiens_hsa054160.29957771
165Rheumatoid arthritis_Homo sapiens_hsa053230.29320231

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