TAF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fucose catabolic process (GO:0019317)5.04874731
2L-fucose metabolic process (GO:0042354)5.04874731
3L-fucose catabolic process (GO:0042355)5.04874731
4behavioral response to nicotine (GO:0035095)4.94101979
5protein localization to kinetochore (GO:0034501)4.40084177
6indole-containing compound catabolic process (GO:0042436)4.30996019
7indolalkylamine catabolic process (GO:0046218)4.30996019
8tryptophan catabolic process (GO:0006569)4.30996019
9kynurenine metabolic process (GO:0070189)4.09544014
10mitotic nuclear envelope disassembly (GO:0007077)3.91948362
11protein localization to chromosome, centromeric region (GO:0071459)3.88287547
12DNA deamination (GO:0045006)3.84741885
13DNA unwinding involved in DNA replication (GO:0006268)3.84665801
14maturation of SSU-rRNA (GO:0030490)3.84151831
15formation of translation preinitiation complex (GO:0001731)3.83660896
16tryptophan metabolic process (GO:0006568)3.79457769
17indolalkylamine metabolic process (GO:0006586)3.74698938
18mitotic metaphase plate congression (GO:0007080)3.69554868
19nucleobase biosynthetic process (GO:0046112)3.62823091
20IMP biosynthetic process (GO:0006188)3.62299131
21DNA strand elongation involved in DNA replication (GO:0006271)3.61678640
22membrane disassembly (GO:0030397)3.61517320
23nuclear envelope disassembly (GO:0051081)3.61517320
24DNA replication initiation (GO:0006270)3.58650343
25mitotic chromosome condensation (GO:0007076)3.53312133
26ribosomal small subunit assembly (GO:0000028)3.49283847
27ribosome assembly (GO:0042255)3.48953997
28DNA replication checkpoint (GO:0000076)3.47651511
29replication fork processing (GO:0031297)3.45638776
30DNA strand elongation (GO:0022616)3.44046470
31folic acid-containing compound biosynthetic process (GO:0009396)3.43812698
32purine nucleobase biosynthetic process (GO:0009113)3.42344610
33viral transcription (GO:0019083)3.40930156
34regulation of spindle organization (GO:0090224)3.39290565
35negative regulation of DNA-dependent DNA replication (GO:2000104)3.38524633
36translational termination (GO:0006415)3.38239817
37double-strand break repair via homologous recombination (GO:0000724)3.37589055
38sulfation (GO:0051923)3.37409283
39recombinational repair (GO:0000725)3.36751001
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.32589610
41ribosome biogenesis (GO:0042254)3.32576121
42positive regulation of defense response to virus by host (GO:0002230)3.32022139
43protein K11-linked deubiquitination (GO:0035871)3.30715553
44regulation of hippo signaling (GO:0035330)3.29848112
45water-soluble vitamin biosynthetic process (GO:0042364)3.29136370
46cellular ketone body metabolic process (GO:0046950)3.28496965
47negative regulation of histone methylation (GO:0031061)3.27308246
48nuclear pore organization (GO:0006999)3.27103884
49IMP metabolic process (GO:0046040)3.26263035
50telomere maintenance via semi-conservative replication (GO:0032201)3.24665306
51mitotic sister chromatid segregation (GO:0000070)3.22374238
52metaphase plate congression (GO:0051310)3.17462503
53negative regulation of telomere maintenance (GO:0032205)3.16371519
54positive regulation of chromosome segregation (GO:0051984)3.15916679
55respiratory chain complex IV assembly (GO:0008535)3.15504691
56translational initiation (GO:0006413)3.15010620
57cellular response to exogenous dsRNA (GO:0071360)3.12441097
58translational elongation (GO:0006414)3.11915611
59reciprocal DNA recombination (GO:0035825)3.11692051
60reciprocal meiotic recombination (GO:0007131)3.11692051
61nuclear pore complex assembly (GO:0051292)3.11241921
62regulation of translational termination (GO:0006449)3.11014558
63ribonucleoprotein complex biogenesis (GO:0022613)3.10746288
64signal peptide processing (GO:0006465)3.10055302
65interkinetic nuclear migration (GO:0022027)3.09170616
66cytidine metabolic process (GO:0046087)3.08952227
67cytidine catabolic process (GO:0006216)3.08952227
68cytidine deamination (GO:0009972)3.08952227
69regulation of histone H3-K9 methylation (GO:0051570)3.08000158
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.07880493
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07346000
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.06739102
73ketone body metabolic process (GO:1902224)3.05589909
74regulation of mitotic spindle organization (GO:0060236)3.05264216
75DNA duplex unwinding (GO:0032508)3.04102678
76DNA demethylation (GO:0080111)3.03493046
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.02563812
78DNA replication-dependent nucleosome assembly (GO:0006335)3.02359919
79DNA replication-dependent nucleosome organization (GO:0034723)3.02359919
80DNA geometric change (GO:0032392)3.02303976
81ribosomal large subunit biogenesis (GO:0042273)2.98751413
82regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97820035
83piRNA metabolic process (GO:0034587)2.94380880
84spliceosomal snRNP assembly (GO:0000387)2.93574212
85nuclear envelope organization (GO:0006998)2.93425347
86telomere maintenance via recombination (GO:0000722)2.92958310
87ribosomal small subunit biogenesis (GO:0042274)2.92891229
88protein localization to chromosome (GO:0034502)2.92582776
89sister chromatid segregation (GO:0000819)2.91933067
90cytochrome complex assembly (GO:0017004)2.89081089
91negative regulation of mast cell activation (GO:0033004)2.88097726
92negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.88080582
93negative regulation of translation, ncRNA-mediated (GO:0040033)2.88080582
94regulation of translation, ncRNA-mediated (GO:0045974)2.88080582
95rRNA processing (GO:0006364)2.87909733
96regulation of translation in response to stress (GO:0043555)2.87161582
97regulation of telomere maintenance via telomerase (GO:0032210)2.87014474
98attachment of spindle microtubules to kinetochore (GO:0008608)2.86847291
99detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.84137205
100neural tube formation (GO:0001841)2.81199014
101mitotic G1 DNA damage checkpoint (GO:0031571)2.81056782
102establishment of chromosome localization (GO:0051303)2.80598012
103mitotic recombination (GO:0006312)2.80103537
104telomere maintenance via telomere lengthening (GO:0010833)2.79486984
105rRNA catabolic process (GO:0016075)2.79429195
106oxidative demethylation (GO:0070989)2.79025759
107rRNA metabolic process (GO:0016072)2.78011844
108DNA damage response, signal transduction resulting in transcription (GO:0042772)2.77669562
109synapsis (GO:0007129)2.76992647
110pyrimidine ribonucleoside catabolic process (GO:0046133)2.76447648
111regulation of nuclear cell cycle DNA replication (GO:0033262)2.76319937
112regulation of memory T cell differentiation (GO:0043380)2.76203095
113regulation of histone H3-K27 methylation (GO:0061085)2.75994851
114NAD biosynthetic process (GO:0009435)2.75808938
115negative regulation of RNA splicing (GO:0033119)2.75580803
116regulation of DNA endoreduplication (GO:0032875)2.75547720
117somatic hypermutation of immunoglobulin genes (GO:0016446)2.75323274
118somatic diversification of immune receptors via somatic mutation (GO:0002566)2.75323274
119negative regulation of chromosome segregation (GO:0051985)2.74680681
120preassembly of GPI anchor in ER membrane (GO:0016254)2.74434801
121CENP-A containing nucleosome assembly (GO:0034080)2.73567818
122regulation of chromosome segregation (GO:0051983)2.71134790
123mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.71126627
124mitochondrial respiratory chain complex I assembly (GO:0032981)2.71126627
125NADH dehydrogenase complex assembly (GO:0010257)2.71126627
126positive regulation of gamma-delta T cell activation (GO:0046645)2.70103657
127protein complex biogenesis (GO:0070271)2.69660466
128folic acid metabolic process (GO:0046655)2.69504469
129chromatin remodeling at centromere (GO:0031055)2.69165063
130negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.69143161
131DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.69139572
132DNA replication-independent nucleosome assembly (GO:0006336)2.67502945
133DNA replication-independent nucleosome organization (GO:0034724)2.67502945
134peptidyl-histidine modification (GO:0018202)2.67241755
135RNA splicing, via transesterification reactions (GO:0000375)2.67046214
136negative regulation of mitotic sister chromatid separation (GO:2000816)2.66976233
137negative regulation of mitotic sister chromatid segregation (GO:0033048)2.66976233
138negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.66976233
139negative regulation of sister chromatid segregation (GO:0033046)2.66976233
140RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.66572251
141mRNA splicing, via spliceosome (GO:0000398)2.66572251
142pre-miRNA processing (GO:0031054)2.66504929
143mitotic spindle assembly checkpoint (GO:0007094)2.65457158
144regulation of gene silencing by RNA (GO:0060966)2.65405476
145regulation of posttranscriptional gene silencing (GO:0060147)2.65405476
146regulation of gene silencing by miRNA (GO:0060964)2.65405476
147spindle assembly checkpoint (GO:0071173)2.64694154
148maturation of 5.8S rRNA (GO:0000460)2.64689966
149cellular response to ATP (GO:0071318)2.64133041
150pseudouridine synthesis (GO:0001522)2.63804260
151cellular biogenic amine catabolic process (GO:0042402)2.63468682
152amine catabolic process (GO:0009310)2.63468682
153DNA methylation involved in gamete generation (GO:0043046)2.62611863
154platelet dense granule organization (GO:0060155)2.62193899
155cellular protein complex disassembly (GO:0043624)2.61938881
156nuclear-transcribed mRNA catabolic process (GO:0000956)2.61787667
157spindle checkpoint (GO:0031577)2.60696374
158meiotic chromosome segregation (GO:0045132)2.60352537
159organelle membrane fusion (GO:0090174)2.60238935
160DNA double-strand break processing (GO:0000729)2.59652519
161viral life cycle (GO:0019058)2.59606454
162negative regulation of mRNA processing (GO:0050686)2.59510486
163detection of light stimulus involved in sensory perception (GO:0050962)2.59205676
164detection of light stimulus involved in visual perception (GO:0050908)2.59205676
165multicellular organism reproduction (GO:0032504)2.58039765
166SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.57414684
167mitochondrial respiratory chain complex assembly (GO:0033108)2.57333431
168positive regulation of developmental pigmentation (GO:0048087)2.57139336
169indole-containing compound metabolic process (GO:0042430)2.54320662
170epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.52989479
171response to pheromone (GO:0019236)2.52981478
172maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.52820263
173protein K6-linked ubiquitination (GO:0085020)2.52423865
174replicative senescence (GO:0090399)2.51074048
175fucosylation (GO:0036065)2.47544347
176nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.47515127
177axoneme assembly (GO:0035082)2.47166966
178exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.44484090
179male meiosis I (GO:0007141)2.44289539
180prenylation (GO:0097354)2.43412710
181protein prenylation (GO:0018342)2.43412710
182kidney morphogenesis (GO:0060993)2.41311544
183protein K63-linked deubiquitination (GO:0070536)2.40311117
184negative regulation of execution phase of apoptosis (GO:1900118)2.38614927
185autophagic vacuole fusion (GO:0000046)2.37793852
186phosphatidylinositol acyl-chain remodeling (GO:0036149)2.37444840
187cornea development in camera-type eye (GO:0061303)2.37437121
188regulation of telomere maintenance (GO:0032204)2.36682360
189positive regulation of mRNA catabolic process (GO:0061014)2.35635903
190snRNA transcription (GO:0009301)2.35551690
191establishment of protein localization to Golgi (GO:0072600)2.35458695
192protein K48-linked deubiquitination (GO:0071108)2.35105744
193aromatic amino acid family catabolic process (GO:0009074)2.34133991

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.85501827
2ZNF274_21170338_ChIP-Seq_K562_Hela4.15053709
3* FOXM1_23109430_ChIP-Seq_U2OS_Human4.02986678
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.47516806
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32630733
6VDR_22108803_ChIP-Seq_LS180_Human3.31364265
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.28682527
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91765962
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.86981488
10* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80479291
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.66952272
12MYC_22102868_ChIP-Seq_BL_Human2.62712884
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52637611
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.51022610
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.38508383
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.36075866
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34702541
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33075121
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.26711619
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.23607833
21EWS_26573619_Chip-Seq_HEK293_Human2.20059019
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16484263
23XRN2_22483619_ChIP-Seq_HELA_Human2.15006990
24* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07935521
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.05543739
26IGF1R_20145208_ChIP-Seq_DFB_Human2.04634676
27GABP_17652178_ChIP-ChIP_JURKAT_Human2.01889792
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01801348
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99863476
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99305191
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93603405
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93306389
33ER_23166858_ChIP-Seq_MCF-7_Human1.92357154
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90573862
35GBX2_23144817_ChIP-Seq_PC3_Human1.89772326
36VDR_23849224_ChIP-Seq_CD4+_Human1.88182588
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87813602
38FUS_26573619_Chip-Seq_HEK293_Human1.86823609
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84852885
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84676017
41CIITA_25753668_ChIP-Seq_RAJI_Human1.84135604
42AR_21909140_ChIP-Seq_LNCAP_Human1.81986359
43* VDR_21846776_ChIP-Seq_THP-1_Human1.81443903
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80818758
45FOXP3_21729870_ChIP-Seq_TREG_Human1.77739297
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75761216
47IRF1_19129219_ChIP-ChIP_H3396_Human1.73878876
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72898736
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66755687
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66272715
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.65857457
52GABP_19822575_ChIP-Seq_HepG2_Human1.62300892
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61831181
54MYC_18940864_ChIP-ChIP_HL60_Human1.61470071
55TP53_22573176_ChIP-Seq_HFKS_Human1.59435581
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59253395
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59144067
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56570213
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56559723
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56469096
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56020731
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55172951
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54771669
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53854336
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52609842
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52470787
67* KDM5A_27292631_Chip-Seq_BREAST_Human1.50956252
68* P300_19829295_ChIP-Seq_ESCs_Human1.50114970
69* GATA3_26560356_Chip-Seq_TH2_Human1.49123050
70DCP1A_22483619_ChIP-Seq_HELA_Human1.48476814
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47543007
72TAF15_26573619_Chip-Seq_HEK293_Human1.47380341
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45189397
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45087003
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41880416
76STAT3_23295773_ChIP-Seq_U87_Human1.41848964
77BCAT_22108803_ChIP-Seq_LS180_Human1.40790188
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39773378
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.37813197
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37813197
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36738902
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36310092
83* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36214981
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36135715
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36013661
86TTF2_22483619_ChIP-Seq_HELA_Human1.35719810
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34511368
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33501435
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32580670
90CBP_20019798_ChIP-Seq_JUKART_Human1.32580670
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31304040
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.31254081
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30696274
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29838525
95HOXB7_26014856_ChIP-Seq_BT474_Human1.29614518
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29587634
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29581380
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29434628
99GATA3_21878914_ChIP-Seq_MCF-7_Human1.28987154
100TFEB_21752829_ChIP-Seq_HELA_Human1.28144537
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.27781834
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26903741
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25930174
104SOX2_19829295_ChIP-Seq_ESCs_Human1.25710259
105NANOG_19829295_ChIP-Seq_ESCs_Human1.25710259
106AR_20517297_ChIP-Seq_VCAP_Human1.25536058
107HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25406433
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25092491
109IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25030635
110MAF_26560356_Chip-Seq_TH1_Human1.24572098
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24504993
112KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24504993
113KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24504993
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24366763
115TCF4_23295773_ChIP-Seq_U87_Human1.24298253
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.21923940
117IRF8_21731497_ChIP-ChIP_J774_Mouse1.21528000
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21375310
119SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21319794
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.20951279
121* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20074341
122SPI1_23547873_ChIP-Seq_NB4_Human1.19337716
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18759775
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18689012
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18672923
126YY1_21170310_ChIP-Seq_MESCs_Mouse1.18504084
127* UTX_26944678_Chip-Seq_JUKART_Human1.17969002
128FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17318170
129PRDM14_20953172_ChIP-Seq_ESCs_Human1.16170714
130KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14926683
131NCOR_22424771_ChIP-Seq_293T_Human1.14469348
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14051047
133FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13048056
134POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12105708
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12105708
136MYB_26560356_Chip-Seq_TH1_Human1.11491366
137FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11203606
138HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10347078
139EZH2_22144423_ChIP-Seq_EOC_Human1.09029797
140ELK1_19687146_ChIP-ChIP_HELA_Human1.08922820
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08860763
142MYB_26560356_Chip-Seq_TH2_Human1.08860753
143ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08132407
144ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07640073
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07458284
146TCF4_22108803_ChIP-Seq_LS180_Human1.07087242
147* TCF7_22412390_ChIP-Seq_EML_Mouse1.06142340
148AR_25329375_ChIP-Seq_VCAP_Human1.05414271
149CRX_20693478_ChIP-Seq_RETINA_Mouse1.04316341
150GATA3_26560356_Chip-Seq_TH1_Human1.03746406
151SMAD4_21741376_ChIP-Seq_EPCs_Human1.02766347
152BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02328435
153PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02227162
154POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01713948
155MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01639111
156SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00922533
157ELK3_25401928_ChIP-Seq_HUVEC_Human1.00680534
158RUNX_20019798_ChIP-Seq_JUKART_Human1.00250041
159GATA1_22025678_ChIP-Seq_K562_Human1.00206389
160SCL_19346495_ChIP-Seq_HPC-7_Human0.99981571
161FLI1_21867929_ChIP-Seq_TH2_Mouse0.99394009
162GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99280203
163* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98954120
164E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98886696
165STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97799211
166NANOG_21062744_ChIP-ChIP_HESCs_Human0.97437225
167ERA_21632823_ChIP-Seq_H3396_Human0.97185430
168* MAF_26560356_Chip-Seq_TH2_Human0.96621459
169CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96529618
170RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95843720
171AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95696035
172* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95325958
173CDX2_22108803_ChIP-Seq_LS180_Human0.95213842
174* RUNX1_22412390_ChIP-Seq_EML_Mouse0.94089056
175* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94070786
176PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93692621
177KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93258496
178SMAD4_21799915_ChIP-Seq_A2780_Human0.92944026
179MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91638172
180* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91331740
181* SRF_21415370_ChIP-Seq_HL-1_Mouse0.90930053
182KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90680804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.28981698
2MP0003111_abnormal_nucleus_morphology3.94596300
3MP0010094_abnormal_chromosome_stability3.69730865
4MP0003195_calcinosis3.62189178
5MP0003077_abnormal_cell_cycle3.60298541
6MP0003646_muscle_fatigue3.48013317
7* MP0004957_abnormal_blastocyst_morpholog3.41049004
8MP0000569_abnormal_digit_pigmentation3.20426209
9MP0008057_abnormal_DNA_replication3.18493089
10MP0002396_abnormal_hematopoietic_system2.89194158
11MP0008058_abnormal_DNA_repair2.76824006
12MP0003763_abnormal_thymus_physiology2.42132545
13MP0002837_dystrophic_cardiac_calcinosis2.37017705
14MP0000685_abnormal_immune_system2.21914447
15MP0008007_abnormal_cellular_replicative2.20438313
16MP0005174_abnormal_tail_pigmentation2.20420548
17MP0001730_embryonic_growth_arrest2.17355226
18MP0000350_abnormal_cell_proliferation2.16283740
19MP0002876_abnormal_thyroid_physiology2.03826980
20MP0004043_abnormal_pH_regulation2.02881168
21MP0005551_abnormal_eye_electrophysiolog1.92740707
22MP0006292_abnormal_olfactory_placode1.91804928
23MP0001986_abnormal_taste_sensitivity1.90642459
24MP0002398_abnormal_bone_marrow1.89986107
25MP0002102_abnormal_ear_morphology1.88224809
26MP0005645_abnormal_hypothalamus_physiol1.87825981
27MP0003786_premature_aging1.86734027
28MP0004808_abnormal_hematopoietic_stem1.81212254
29MP0008875_abnormal_xenobiotic_pharmacok1.78515329
30MP0000490_abnormal_crypts_of1.77589447
31MP0009333_abnormal_splenocyte_physiolog1.76721472
32MP0002722_abnormal_immune_system1.74468241
33MP0000703_abnormal_thymus_morphology1.74159316
34MP0000689_abnormal_spleen_morphology1.73766405
35MP0008932_abnormal_embryonic_tissue1.73598679
36MP0001545_abnormal_hematopoietic_system1.72982810
37MP0005397_hematopoietic_system_phenotyp1.72982810
38MP0008872_abnormal_physiological_respon1.72245604
39MP0000427_abnormal_hair_cycle1.71372810
40MP0010352_gastrointestinal_tract_polyps1.69885670
41MP0002019_abnormal_tumor_incidence1.69325578
42MP0000372_irregular_coat_pigmentation1.69175112
43MP0003718_maternal_effect1.68803633
44MP0001800_abnormal_humoral_immune1.68628553
45MP0010307_abnormal_tumor_latency1.64935080
46MP0001697_abnormal_embryo_size1.62661850
47MP0001672_abnormal_embryogenesis/_devel1.60131444
48MP0005380_embryogenesis_phenotype1.60131444
49MP0004147_increased_porphyrin_level1.55227399
50MP0005671_abnormal_response_to1.53775068
51MP0000313_abnormal_cell_death1.52984208
52* MP0002080_prenatal_lethality1.52679273
53MP0009278_abnormal_bone_marrow1.49987598
54MP0003984_embryonic_growth_retardation1.48466360
55MP0003787_abnormal_imprinting1.47616561
56MP0000716_abnormal_immune_system1.45269863
57MP0002088_abnormal_embryonic_growth/wei1.44872492
58MP0002429_abnormal_blood_cell1.43468116
59MP0002095_abnormal_skin_pigmentation1.43291005
60MP0006072_abnormal_retinal_apoptosis1.41021211
61MP0001485_abnormal_pinna_reflex1.39500828
62MP0008961_abnormal_basal_metabolism1.39152779
63MP0002086_abnormal_extraembryonic_tissu1.38841938
64* MP0002085_abnormal_embryonic_tissue1.37170735
65MP0005076_abnormal_cell_differentiation1.36526512
66MP0002163_abnormal_gland_morphology1.36173810
67MP0004142_abnormal_muscle_tone1.35646845
68MP0005253_abnormal_eye_physiology1.35561645
69MP0003136_yellow_coat_color1.34297214
70MP0002938_white_spotting1.34021670
71MP0002420_abnormal_adaptive_immunity1.31631201
72MP0002452_abnormal_antigen_presenting1.29770975
73MP0001819_abnormal_immune_cell1.29529676
74MP0002084_abnormal_developmental_patter1.29482879
75MP0003123_paternal_imprinting1.29399220
76MP0005389_reproductive_system_phenotype1.28709831
77MP0000015_abnormal_ear_pigmentation1.27302433
78MP0008995_early_reproductive_senescence1.25821618
79MP0002723_abnormal_immune_serum1.24786928
80MP0001919_abnormal_reproductive_system1.23882589
81MP0001968_abnormal_touch/_nociception1.20755065
82MP0003566_abnormal_cell_adhesion1.17889510
83MP0004130_abnormal_muscle_cell1.17433195
84MP0002653_abnormal_ependyma_morphology1.14875509
85MP0000631_abnormal_neuroendocrine_gland1.12002616
86MP0001835_abnormal_antigen_presentation1.11228585
87MP0004197_abnormal_fetal_growth/weight/1.09812503
88MP0002693_abnormal_pancreas_physiology1.08227536
89MP0002638_abnormal_pupillary_reflex1.07553914
90MP0005387_immune_system_phenotype1.07139511
91MP0001790_abnormal_immune_system1.07139511
92MP0005084_abnormal_gallbladder_morpholo1.06955070
93MP0002405_respiratory_system_inflammati1.06548490
94MP0001873_stomach_inflammation1.06325477
95MP0004145_abnormal_muscle_electrophysio1.05179549
96MP0005075_abnormal_melanosome_morpholog1.04848463
97MP0001324_abnormal_eye_pigmentation1.04605005
98MP0005379_endocrine/exocrine_gland_phen1.03537160
99MP0005621_abnormal_cell_physiology1.02765467
100MP0008877_abnormal_DNA_methylation1.02410320
101MP0000383_abnormal_hair_follicle1.02319293
102MP0004947_skin_inflammation1.01477653
103MP0008775_abnormal_heart_ventricle1.00683984
104MP0002160_abnormal_reproductive_system0.99955103
105MP0002009_preneoplasia0.99579504
106MP0004381_abnormal_hair_follicle0.99507681
107MP0002277_abnormal_respiratory_mucosa0.98187286
108MP0003567_abnormal_fetal_cardiomyocyte0.98125325
109MP0002138_abnormal_hepatobiliary_system0.97005709
110MP0005310_abnormal_salivary_gland0.96479814
111MP0003252_abnormal_bile_duct0.95760959
112MP0000465_gastrointestinal_hemorrhage0.94587974
113MP0001293_anophthalmia0.94303653
114MP0010155_abnormal_intestine_physiology0.93987367
115MP0005083_abnormal_biliary_tract0.93547294
116MP0002148_abnormal_hypersensitivity_rea0.93516363
117MP0001501_abnormal_sleep_pattern0.93460271
118MP0005167_abnormal_blood-brain_barrier0.93199319
119MP0009046_muscle_twitch0.92940618
120MP0005000_abnormal_immune_tolerance0.92821797
121MP0005332_abnormal_amino_acid0.92743778
122MP0002928_abnormal_bile_duct0.92199252
123MP0001915_intracranial_hemorrhage0.91455027
124MP0000858_altered_metastatic_potential0.91407934
125MP0005266_abnormal_metabolism0.91221612
126MP0000371_diluted_coat_color0.91201261
127MP0005025_abnormal_response_to0.91188019
128MP0005646_abnormal_pituitary_gland0.91085524
129MP0004133_heterotaxia0.90821224
130MP0005023_abnormal_wound_healing0.90746185
131MP0004885_abnormal_endolymph0.90087908
132MP0005384_cellular_phenotype0.89700959
133MP0003950_abnormal_plasma_membrane0.89394831
134MP0003806_abnormal_nucleotide_metabolis0.88081152
135MP0003866_abnormal_defecation0.88024464
136MP0002166_altered_tumor_susceptibility0.87945867
137MP0009764_decreased_sensitivity_to0.87751738
138MP0001853_heart_inflammation0.87482437
139MP0001764_abnormal_homeostasis0.86506402
140MP0002210_abnormal_sex_determination0.85178292
141MP0009840_abnormal_foam_cell0.82236868
142MP0000477_abnormal_intestine_morphology0.81718606
143MP0010329_abnormal_lipoprotein_level0.80866667
144MP0003943_abnormal_hepatobiliary_system0.80763945
145MP0003724_increased_susceptibility_to0.79506615
146MP0003221_abnormal_cardiomyocyte_apopto0.79034914
147MP0001145_abnormal_male_reproductive0.78690918
148MP0001849_ear_inflammation0.78543511
149MP0004264_abnormal_extraembryonic_tissu0.78439462
150MP0005464_abnormal_platelet_physiology0.77959516
151MP0003436_decreased_susceptibility_to0.77772997
152MP0000230_abnormal_systemic_arterial0.77725185
153MP0003705_abnormal_hypodermis_morpholog0.76855721
154MP0006036_abnormal_mitochondrial_physio0.76702192
155MP0005085_abnormal_gallbladder_physiolo0.75697155
156MP0005195_abnormal_posterior_eye0.73159325
157MP0001119_abnormal_female_reproductive0.72503398
158MP0005410_abnormal_fertilization0.72488916
159MP0001929_abnormal_gametogenesis0.71494105
160MP0000358_abnormal_cell_content/0.71191861
161MP0000428_abnormal_craniofacial_morphol0.67250188
162MP0003303_peritoneal_inflammation0.66643173
163MP0000653_abnormal_sex_gland0.66427260
164MP0000733_abnormal_muscle_development0.65372228
165MP0006054_spinal_hemorrhage0.64847402
166MP0010030_abnormal_orbit_morphology0.64163702
167MP0008260_abnormal_autophagy0.63970695
168MP0001845_abnormal_inflammatory_respons0.62776501
169MP0009672_abnormal_birth_weight0.61746647
170MP0009785_altered_susceptibility_to0.61243953
171MP0003448_altered_tumor_morphology0.60520569

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.73151732
2Pancreatic fibrosis (HP:0100732)3.90352367
3Molar tooth sign on MRI (HP:0002419)3.73712006
4Abnormality of midbrain morphology (HP:0002418)3.73712006
5True hermaphroditism (HP:0010459)3.62656308
6Congenital stationary night blindness (HP:0007642)3.61313055
7Birth length less than 3rd percentile (HP:0003561)3.56935345
8IgM deficiency (HP:0002850)3.49724845
9Nephronophthisis (HP:0000090)3.31677689
10Selective tooth agenesis (HP:0001592)3.25351113
11Abnormality of the renal cortex (HP:0011035)3.24842122
12Ependymoma (HP:0002888)3.20665226
13Reticulocytopenia (HP:0001896)3.04274423
14Attenuation of retinal blood vessels (HP:0007843)2.97433996
15Abnormality of the renal medulla (HP:0100957)2.93395406
16Breast hypoplasia (HP:0003187)2.93088732
17Premature ovarian failure (HP:0008209)2.88709002
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88518493
19Abnormality of alanine metabolism (HP:0010916)2.88518493
20Hyperalaninemia (HP:0003348)2.88518493
21Tubular atrophy (HP:0000092)2.86498366
22Carpal bone hypoplasia (HP:0001498)2.85410532
23Patellar aplasia (HP:0006443)2.75799803
24Medulloblastoma (HP:0002885)2.73511020
25Large for gestational age (HP:0001520)2.72647804
26Cerebral hypomyelination (HP:0006808)2.70625449
27Abnormality of the fingertips (HP:0001211)2.70602577
28Abnormality of cells of the erythroid lineage (HP:0012130)2.66802114
29T lymphocytopenia (HP:0005403)2.66212386
30Rhabdomyosarcoma (HP:0002859)2.66206410
31Basal cell carcinoma (HP:0002671)2.66002966
32Oral leukoplakia (HP:0002745)2.65849143
33Cystic liver disease (HP:0006706)2.65423280
34Thrombocytosis (HP:0001894)2.65000180
35Pendular nystagmus (HP:0012043)2.64591961
36Abolished electroretinogram (ERG) (HP:0000550)2.61793526
37Abnormality of T cells (HP:0002843)2.59519350
38Aplastic anemia (HP:0001915)2.58976705
39Colon cancer (HP:0003003)2.57942599
40Secondary amenorrhea (HP:0000869)2.57293503
41Myelodysplasia (HP:0002863)2.54210119
42Aplasia/Hypoplasia of the patella (HP:0006498)2.52807143
43Type II lissencephaly (HP:0007260)2.51136963
44Abnormality of T cell number (HP:0011839)2.49824286
45Genetic anticipation (HP:0003743)2.49525712
46Abnormal drinking behavior (HP:0030082)2.49272640
47Polydipsia (HP:0001959)2.49272640
48Medial flaring of the eyebrow (HP:0010747)2.48749210
49Clumsiness (HP:0002312)2.48546546
50Stomatitis (HP:0010280)2.45505663
51Gaze-evoked nystagmus (HP:0000640)2.44243250
52Impulsivity (HP:0100710)2.44193970
53Multiple enchondromatosis (HP:0005701)2.43777078
54Abnormal number of erythroid precursors (HP:0012131)2.41904455
55Absent radius (HP:0003974)2.41607427
56Hyperventilation (HP:0002883)2.41198066
57Combined immunodeficiency (HP:0005387)2.40233677
58Protruding tongue (HP:0010808)2.39927108
59Amaurosis fugax (HP:0100576)2.39717559
60Fair hair (HP:0002286)2.36827708
61Abnormality of the pons (HP:0007361)2.34349036
62Recurrent bronchitis (HP:0002837)2.33933594
63Furrowed tongue (HP:0000221)2.33672557
64Neoplasm of striated muscle (HP:0009728)2.33161695
65Chronic hepatic failure (HP:0100626)2.32889507
66Lymphoma (HP:0002665)2.32852738
67Progressive inability to walk (HP:0002505)2.32129882
68Abnormal rod and cone electroretinograms (HP:0008323)2.31795560
69Pustule (HP:0200039)2.30023775
70Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.28146384
71Thyroiditis (HP:0100646)2.27124479
72IgG deficiency (HP:0004315)2.26788006
73Chromsome breakage (HP:0040012)2.26012990
74Sclerocornea (HP:0000647)2.25618493
75Recurrent viral infections (HP:0004429)2.25287691
76Abnormality of T cell physiology (HP:0011840)2.24897947
77Abnormality of cells of the lymphoid lineage (HP:0012140)2.24070147
78Abnormality of the anterior horn cell (HP:0006802)2.23903444
79Degeneration of anterior horn cells (HP:0002398)2.23903444
80Abnormality of the renal collecting system (HP:0004742)2.23585727
81Duplicated collecting system (HP:0000081)2.22763911
82Cellular immunodeficiency (HP:0005374)2.22388574
83Stomach cancer (HP:0012126)2.21769260
84Absent forearm bone (HP:0003953)2.19406023
85Aplasia involving forearm bones (HP:0009822)2.19406023
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19338109
87Renal cortical cysts (HP:0000803)2.18872559
88Rough bone trabeculation (HP:0100670)2.18748290
89Increased nuchal translucency (HP:0010880)2.18075871
90Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15128282
91Inability to walk (HP:0002540)2.14709775
92Lymphopenia (HP:0001888)2.13422103
93Hypoplasia of the pons (HP:0012110)2.13333872
94Proximal placement of thumb (HP:0009623)2.12903731
95Bile duct proliferation (HP:0001408)2.11040866
96Abnormal biliary tract physiology (HP:0012439)2.11040866
97Abnormality of chromosome stability (HP:0003220)2.10107930
98Congenital hepatic fibrosis (HP:0002612)2.08993670
99Gonadotropin excess (HP:0000837)2.08917180
100Absent thumb (HP:0009777)2.07529372
101Abnormality of the labia minora (HP:0012880)2.07512282
102Aplasia/Hypoplasia of the tongue (HP:0010295)2.06476946
103Congenital, generalized hypertrichosis (HP:0004540)2.06036961
104Facial hemangioma (HP:0000329)2.05644853
105Neoplasm of the oral cavity (HP:0100649)2.05190589
106Progressive cerebellar ataxia (HP:0002073)2.05102282
107Neoplasm of the pancreas (HP:0002894)2.04981232
108Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03367664
109Decreased circulating renin level (HP:0003351)2.03363170
110Chronic otitis media (HP:0000389)2.03314900
111Agnosia (HP:0010524)2.03116643
112Abnormality of the ileum (HP:0001549)2.02656664
113Meckel diverticulum (HP:0002245)2.02196974
114Macrocytic anemia (HP:0001972)2.00722802
115Clubbing of toes (HP:0100760)1.99577086
116Decreased central vision (HP:0007663)1.99178485
117Entropion (HP:0000621)1.98652575
118Poikiloderma (HP:0001029)1.98621865
119Abnormal delayed hypersensitivity skin test (HP:0002963)1.98297660
120Panhypogammaglobulinemia (HP:0003139)1.98293264
121Anencephaly (HP:0002323)1.98199663
122Granulocytopenia (HP:0001913)1.97979144
123Severe combined immunodeficiency (HP:0004430)1.97174646
124Deviation of the thumb (HP:0009603)1.96856413
125Abnormality of the preputium (HP:0100587)1.96003028
126Sloping forehead (HP:0000340)1.95976711
127Methylmalonic acidemia (HP:0002912)1.95698856
128Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95529070
129Skin tags (HP:0010609)1.94977976
130Chorioretinal atrophy (HP:0000533)1.94908185
131Prominent nose (HP:0000448)1.94632382
132Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92801765
133Microretrognathia (HP:0000308)1.92510315
134Leukopenia (HP:0001882)1.92221457
135Preauricular skin tag (HP:0000384)1.91932496
136Aplasia/Hypoplasia of the tibia (HP:0005772)1.91701659
137Ketoacidosis (HP:0001993)1.91148859
138Methylmalonic aciduria (HP:0012120)1.89797218
139Heterotopia (HP:0002282)1.89101815
140Abnormality of B cell number (HP:0010975)1.88994596
141B lymphocytopenia (HP:0010976)1.88994596
142Generalized hypopigmentation of hair (HP:0011358)1.88482253
143Increased neuronal autofluorescent lipopigment (HP:0002074)1.88346959
144Polyuria (HP:0000103)1.87879077
145Aplasia/Hypoplasia of the uvula (HP:0010293)1.87784344
146Cerebellar dysplasia (HP:0007033)1.87479653
147Pallor (HP:0000980)1.86559617
148Depressed nasal tip (HP:0000437)1.85998752
149Bone marrow hypocellularity (HP:0005528)1.85887040
150Severe muscular hypotonia (HP:0006829)1.85607166
151Neoplasm of the adrenal cortex (HP:0100641)1.85604489
152Trismus (HP:0000211)1.85593927
153CNS hypomyelination (HP:0003429)1.85437654
154Male pseudohermaphroditism (HP:0000037)1.85390702
155Ketosis (HP:0001946)1.85253046
156Progressive muscle weakness (HP:0003323)1.83864643
157Acute lymphatic leukemia (HP:0006721)1.83108533
158Cellulitis (HP:0100658)1.82809774
159Abnormality of DNA repair (HP:0003254)1.82510991
160Ectopic kidney (HP:0000086)1.82326621
161Constricted visual fields (HP:0001133)1.81621473
162Cafe-au-lait spot (HP:0000957)1.81073903
163Increased CSF lactate (HP:0002490)1.80763546
164Increased corneal curvature (HP:0100692)1.80652009
165Keratoconus (HP:0000563)1.80652009
166Premature graying of hair (HP:0002216)1.80393682
167Supernumerary spleens (HP:0009799)1.79907607
168Aplasia/Hypoplasia of the spleen (HP:0010451)1.79294695
169Bony spicule pigmentary retinopathy (HP:0007737)1.78385374
170Hypoproteinemia (HP:0003075)1.75976048
171Recurrent fungal infections (HP:0002841)1.75562058
172Tracheoesophageal fistula (HP:0002575)1.73486670
173Lissencephaly (HP:0001339)1.73451944
174Abnormality of the salivary glands (HP:0010286)1.72842554
175Concave nail (HP:0001598)1.72695534
176Asplenia (HP:0001746)1.72686658
177Hypothermia (HP:0002045)1.71738326
178Papilloma (HP:0012740)1.70923957
179Verrucae (HP:0200043)1.70923957
180Pulmonary fibrosis (HP:0002206)1.69978298
181Small intestinal stenosis (HP:0012848)1.69934687
182Duodenal stenosis (HP:0100867)1.69934687
183Tachypnea (HP:0002789)1.69687582
184IgA deficiency (HP:0002720)1.69332203
185Volvulus (HP:0002580)1.68907374
186Congenital primary aphakia (HP:0007707)1.67975868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.13499600
2BUB14.31668110
3BMPR1B3.62975791
4WEE13.59456989
5ZAK3.34061939
6ADRBK23.25339557
7STK103.12463634
8MAP4K12.84330742
9EEF2K2.79282930
10CDC72.71090257
11NEK22.70841504
12MAPKAPK32.56119090
13WNK42.51495343
14TAOK32.44003814
15CDK122.43173238
16NUAK12.39767087
17MAP3K102.32133411
18GRK12.08411189
19EIF2AK11.91757609
20WNK31.87068415
21FLT31.85683448
22TTK1.76224683
23RPS6KA41.73637580
24MAP4K21.72351113
25RPS6KB21.71884992
26INSRR1.71167004
27LRRK21.58300804
28BRSK21.57717294
29NME21.56605433
30TSSK61.54633585
31CDK41.54195314
32MAP3K81.51581248
33TLK11.50620451
34DYRK31.49669160
35STK391.48081604
36PINK11.47988022
37TRIB31.46571324
38TESK21.45714508
39PLK11.45709054
40JAK31.42851572
41GRK61.40692201
42ACVR1B1.39980421
43PKN21.34142232
44BTK1.31933071
45CDK71.29459649
46ADRBK11.29354833
47ZAP701.27412265
48AURKB1.24912000
49SRPK11.24749692
50ATR1.23332245
51PIM11.21778474
52PLK41.20502618
53CAMKK21.17527602
54MAPK131.16021623
55OXSR11.15814415
56CSF1R1.11333121
57KIT1.08799531
58VRK21.08624925
59PAK41.05702785
60MAP2K61.05126080
61NEK11.03686026
62TAF11.02343689
63STK41.01711389
64DAPK20.94981436
65EIF2AK30.92357137
66ERN10.90548246
67MST40.90347180
68CHEK10.90081760
69BRSK10.89558965
70FGFR40.88169993
71ITK0.88091521
72TRPM70.86953290
73MUSK0.85639848
74ALK0.85482356
75TNK20.84651512
76IRAK10.84425703
77CHEK20.83323317
78PRKCQ0.82206345
79TYK20.81833381
80MAP2K30.81783344
81AURKA0.81395236
82EPHA20.80697009
83TEC0.79792480
84BCKDK0.79562234
85BRD40.78957665
86PASK0.78694177
87TXK0.75973280
88VRK10.74387765
89MKNK20.73689731
90PTK2B0.73107940
91MKNK10.72879473
92TRIM280.70854600
93MAP3K40.68835967
94TGFBR10.68796203
95CDK20.68437051
96PIK3CA0.67211372
97PAK30.65039831
98MELK0.63447557
99WNK10.60885311
100FGFR20.60521062
101PRKAA20.59737803
102CHUK0.59720843
103MTOR0.59506292
104SYK0.59428655
105TGFBR20.58160868
106MATK0.58067737
107MARK30.57884313
108LCK0.57545639
109CDK60.56401836
110STK160.56081026
111MAPK110.56022367
112CAMK1D0.55772575
113HIPK20.54859131
114ATM0.53509378
115STK110.52994795
116IKBKE0.52616880
117RPS6KA50.52589546
118CDK80.50266720
119AKT20.48616229
120OBSCN0.48506456
121FGFR30.47057169
122BLK0.46701180
123STK240.45424470
124STK30.45293115
125PLK30.44861501
126IKBKB0.43965549
127NLK0.43865833
128KDR0.43712118
129CSK0.43545271
130RPS6KA60.43391795
131TIE10.42542810
132TAOK10.42235575
133CSNK2A20.42192087
134PAK10.41278531
135CDK10.41145543
136PRKCE0.39913063
137MAP3K70.39890624
138EPHA30.37580016
139CAMK10.37541831
140MAPKAPK20.36875717
141EIF2AK20.36628795
142LYN0.36477344
143HCK0.35421598
144STK38L0.34696392
145MAP3K110.33434352
146PRKAA10.33157968
147PHKG20.32312398
148PHKG10.32312398
149TTN0.32137274
150PKN10.32022511
151PRKCI0.31319016
152DAPK10.31172342
153TNIK0.30774487
154CLK10.29237466

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.96479283
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.45634813
3Mismatch repair_Homo sapiens_hsa034303.17370957
4Spliceosome_Homo sapiens_hsa030403.12604101
5Base excision repair_Homo sapiens_hsa034103.10281967
6RNA transport_Homo sapiens_hsa030132.99121983
7RNA polymerase_Homo sapiens_hsa030202.91419633
8Ribosome_Homo sapiens_hsa030102.83539428
9Phototransduction_Homo sapiens_hsa047442.58707287
10Cell cycle_Homo sapiens_hsa041102.56198443
11Linoleic acid metabolism_Homo sapiens_hsa005912.53639809
12Nitrogen metabolism_Homo sapiens_hsa009102.53560658
13One carbon pool by folate_Homo sapiens_hsa006702.39781028
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.38599868
15Nucleotide excision repair_Homo sapiens_hsa034202.38161266
16Homologous recombination_Homo sapiens_hsa034402.37014521
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.31514977
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13228400
19Butanoate metabolism_Homo sapiens_hsa006502.04343374
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.03731260
21Pyrimidine metabolism_Homo sapiens_hsa002402.03487996
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94304584
23Primary immunodeficiency_Homo sapiens_hsa053401.91484818
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90307223
25Tryptophan metabolism_Homo sapiens_hsa003801.88406096
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.81760269
27mRNA surveillance pathway_Homo sapiens_hsa030151.80576588
28RNA degradation_Homo sapiens_hsa030181.78994703
29Non-homologous end-joining_Homo sapiens_hsa034501.73988894
30Proteasome_Homo sapiens_hsa030501.73779203
31* Basal transcription factors_Homo sapiens_hsa030221.68992595
32Ether lipid metabolism_Homo sapiens_hsa005651.67720814
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65756670
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64882123
35Fanconi anemia pathway_Homo sapiens_hsa034601.63516398
36p53 signaling pathway_Homo sapiens_hsa041151.60375806
37Antigen processing and presentation_Homo sapiens_hsa046121.45362454
38Epstein-Barr virus infection_Homo sapiens_hsa051691.45344357
39Vitamin B6 metabolism_Homo sapiens_hsa007501.44838871
40Herpes simplex infection_Homo sapiens_hsa051681.44232725
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41877425
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41817594
43Protein export_Homo sapiens_hsa030601.41043936
44Propanoate metabolism_Homo sapiens_hsa006401.40342305
45ABC transporters_Homo sapiens_hsa020101.32966044
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.28637539
47Oxidative phosphorylation_Homo sapiens_hsa001901.28490705
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22683037
49Viral carcinogenesis_Homo sapiens_hsa052031.21554586
50Graft-versus-host disease_Homo sapiens_hsa053321.19867830
51Pentose phosphate pathway_Homo sapiens_hsa000301.12783983
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09493670
53Notch signaling pathway_Homo sapiens_hsa043301.08572598
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05666831
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05372017
56B cell receptor signaling pathway_Homo sapiens_hsa046621.05181682
57Purine metabolism_Homo sapiens_hsa002301.03302100
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02436755
59HTLV-I infection_Homo sapiens_hsa051661.01445927
60Asthma_Homo sapiens_hsa053101.00172079
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.99415836
62Autoimmune thyroid disease_Homo sapiens_hsa053200.97854221
63Allograft rejection_Homo sapiens_hsa053300.97122446
64Measles_Homo sapiens_hsa051620.97106931
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.96614540
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95374226
67Olfactory transduction_Homo sapiens_hsa047400.93424682
68Arachidonic acid metabolism_Homo sapiens_hsa005900.93333380
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.93323232
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92791996
71Biosynthesis of amino acids_Homo sapiens_hsa012300.90597150
72Sulfur relay system_Homo sapiens_hsa041220.89760045
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89527494
74Glycerolipid metabolism_Homo sapiens_hsa005610.89323052
75Type I diabetes mellitus_Homo sapiens_hsa049400.88886109
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88101826
77Apoptosis_Homo sapiens_hsa042100.88067143
78Taste transduction_Homo sapiens_hsa047420.84713966
79Ovarian steroidogenesis_Homo sapiens_hsa049130.84007711
80Parkinsons disease_Homo sapiens_hsa050120.83112298
81Systemic lupus erythematosus_Homo sapiens_hsa053220.82796948
82Chemical carcinogenesis_Homo sapiens_hsa052040.82446422
83MicroRNAs in cancer_Homo sapiens_hsa052060.80966419
84Acute myeloid leukemia_Homo sapiens_hsa052210.80539604
85Thyroid cancer_Homo sapiens_hsa052160.80228089
86Oocyte meiosis_Homo sapiens_hsa041140.78870490
87Peroxisome_Homo sapiens_hsa041460.77250549
88T cell receptor signaling pathway_Homo sapiens_hsa046600.76747418
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76272067
90Small cell lung cancer_Homo sapiens_hsa052220.75661374
91Chronic myeloid leukemia_Homo sapiens_hsa052200.73905805
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73647531
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73489474
94Shigellosis_Homo sapiens_hsa051310.70588830
95Dorso-ventral axis formation_Homo sapiens_hsa043200.69506566
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69471758
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.68729902
98Folate biosynthesis_Homo sapiens_hsa007900.66186647
99Retinol metabolism_Homo sapiens_hsa008300.66111835
100Hepatitis B_Homo sapiens_hsa051610.65260841
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64645205
102Hematopoietic cell lineage_Homo sapiens_hsa046400.64333424
103Huntingtons disease_Homo sapiens_hsa050160.63839624
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.63590652
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63158311
106Selenocompound metabolism_Homo sapiens_hsa004500.61048404
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59977062
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59832914
109Legionellosis_Homo sapiens_hsa051340.59823139
110Influenza A_Homo sapiens_hsa051640.57398790
111Fructose and mannose metabolism_Homo sapiens_hsa000510.57282263
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.56970445
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.56576362
114Colorectal cancer_Homo sapiens_hsa052100.56202065
115mTOR signaling pathway_Homo sapiens_hsa041500.54754109
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53036762
117Morphine addiction_Homo sapiens_hsa050320.51755570
118Lysine degradation_Homo sapiens_hsa003100.48158151
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48151878
120Serotonergic synapse_Homo sapiens_hsa047260.47935684
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.47929994
122Calcium signaling pathway_Homo sapiens_hsa040200.47464820
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46940647
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46895516
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.46653638
126Metabolic pathways_Homo sapiens_hsa011000.45801024
127Viral myocarditis_Homo sapiens_hsa054160.45543394
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44304346
129Bladder cancer_Homo sapiens_hsa052190.43562740
130Pancreatic cancer_Homo sapiens_hsa052120.43179634
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42417690
132Leishmaniasis_Homo sapiens_hsa051400.41622704
133Regulation of autophagy_Homo sapiens_hsa041400.41468696
134Osteoclast differentiation_Homo sapiens_hsa043800.41345926
135Vitamin digestion and absorption_Homo sapiens_hsa049770.40490893
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38735811
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38163705
138Non-small cell lung cancer_Homo sapiens_hsa052230.37970639
139HIF-1 signaling pathway_Homo sapiens_hsa040660.37332120
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.37237210
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36843655
142Pathways in cancer_Homo sapiens_hsa052000.35196914
143Alzheimers disease_Homo sapiens_hsa050100.35153643
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34879163
145Basal cell carcinoma_Homo sapiens_hsa052170.34113556
146Carbon metabolism_Homo sapiens_hsa012000.33831444
147Salivary secretion_Homo sapiens_hsa049700.33577544
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32445454
149beta-Alanine metabolism_Homo sapiens_hsa004100.32360273
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32085657
151Insulin secretion_Homo sapiens_hsa049110.31296161
152Nicotine addiction_Homo sapiens_hsa050330.30251285
153FoxO signaling pathway_Homo sapiens_hsa040680.30170659
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28940945
155VEGF signaling pathway_Homo sapiens_hsa043700.28552164
156Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28218018
157Other glycan degradation_Homo sapiens_hsa005110.27412243
158Toxoplasmosis_Homo sapiens_hsa051450.27352137
159Hippo signaling pathway_Homo sapiens_hsa043900.26626596
160Platelet activation_Homo sapiens_hsa046110.25001098
161Caffeine metabolism_Homo sapiens_hsa002320.23850635

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