TAF9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16. In human, TAF9 and AK6 (GeneID: 102157402) are two distinct genes that share 5' exons. A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)8.74056349
2cilium or flagellum-dependent cell motility (GO:0001539)8.68256809
3fusion of sperm to egg plasma membrane (GO:0007342)8.61790738
4sperm-egg recognition (GO:0035036)8.01443890
5axonemal dynein complex assembly (GO:0070286)7.75739195
6binding of sperm to zona pellucida (GO:0007339)7.70442689
7acrosome assembly (GO:0001675)7.50497066
8piRNA metabolic process (GO:0034587)7.26962087
9acrosome reaction (GO:0007340)7.25961381
10motile cilium assembly (GO:0044458)7.24184575
11cell-cell recognition (GO:0009988)7.14507778
12multicellular organism reproduction (GO:0032504)6.92732848
13epithelial cilium movement (GO:0003351)6.77385203
14spermatid development (GO:0007286)6.77104979
15cell wall macromolecule catabolic process (GO:0016998)6.65679990
16cell wall macromolecule metabolic process (GO:0044036)6.65679990
17male meiosis (GO:0007140)6.51243882
18plasma membrane fusion (GO:0045026)6.42292783
19synaptonemal complex organization (GO:0070193)6.17635006
20regulation of cilium movement (GO:0003352)6.14523650
21synaptonemal complex assembly (GO:0007130)5.97495660
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.86699799
23cilium movement (GO:0003341)5.68267496
24proteasome assembly (GO:0043248)5.64804579
25reproduction (GO:0000003)5.62652967
26microtubule depolymerization (GO:0007019)5.36071847
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.15483261
28single fertilization (GO:0007338)4.94054677
29male meiosis I (GO:0007141)4.90437964
30DNA methylation involved in gamete generation (GO:0043046)4.88404753
31chromosome organization involved in meiosis (GO:0070192)4.64695709
32spermatogenesis (GO:0007283)4.59627699
33male gamete generation (GO:0048232)4.59054355
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.56989871
35meiotic nuclear division (GO:0007126)4.48308742
36ribosome assembly (GO:0042255)4.46546873
37meiosis I (GO:0007127)4.41149700
38cullin deneddylation (GO:0010388)4.40560313
39negative regulation of inclusion body assembly (GO:0090084)4.39946921
40ATP synthesis coupled proton transport (GO:0015986)4.38138216
41energy coupled proton transport, down electrochemical gradient (GO:0015985)4.38138216
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.37561786
43fertilization (GO:0009566)4.35326721
44chaperone-mediated protein transport (GO:0072321)4.28626742
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.25943636
46gamete generation (GO:0007276)4.24828413
47chromosome condensation (GO:0030261)4.19579816
48protein neddylation (GO:0045116)4.15396099
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.15132496
50negative regulation of ligase activity (GO:0051352)4.15132496
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.10624404
52establishment of integrated proviral latency (GO:0075713)4.09500478
53DNA packaging (GO:0006323)4.09155027
54protein deneddylation (GO:0000338)4.08781187
55establishment of protein localization to mitochondrial membrane (GO:0090151)4.08268939
56meiotic cell cycle (GO:0051321)4.07122716
57sperm capacitation (GO:0048240)3.98918968
58rRNA modification (GO:0000154)3.94952759
59DNA double-strand break processing (GO:0000729)3.90493669
60regulation of cellular amino acid metabolic process (GO:0006521)3.89283810
61germ cell development (GO:0007281)3.88212031
62transcription elongation from RNA polymerase III promoter (GO:0006385)3.80758266
63termination of RNA polymerase III transcription (GO:0006386)3.80758266
64protein localization to chromosome, centromeric region (GO:0071459)3.80207272
65mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.79080987
66cellular process involved in reproduction in multicellular organism (GO:0022412)3.77572106
67purine nucleobase biosynthetic process (GO:0009113)3.76705760
68regulation of inclusion body assembly (GO:0090083)3.75428739
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.73716346
70positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.72723995
71monoubiquitinated protein deubiquitination (GO:0035520)3.72192385
72signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.71559379
73signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.71559379
74signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.71559379
75IMP biosynthetic process (GO:0006188)3.70647202
76mitotic sister chromatid cohesion (GO:0007064)3.68580792
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.68268259
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.67852984
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.67852984
80histone exchange (GO:0043486)3.66356528
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.63449271
82seminiferous tubule development (GO:0072520)3.63422739
83respiratory chain complex IV assembly (GO:0008535)3.59969586
84signal transduction involved in DNA integrity checkpoint (GO:0072401)3.58918452
85signal transduction involved in DNA damage checkpoint (GO:0072422)3.58918452
86respiratory electron transport chain (GO:0022904)3.57445248
87positive regulation of ligase activity (GO:0051351)3.56997092
88regulation of spindle checkpoint (GO:0090231)3.55191658
89signal transduction involved in cell cycle checkpoint (GO:0072395)3.53425268
90protein targeting to mitochondrion (GO:0006626)3.52427149
91protein complex biogenesis (GO:0070271)3.51588539
92mitochondrial respiratory chain complex assembly (GO:0033108)3.51301210
93regulation of mitotic spindle checkpoint (GO:1903504)3.51046948
94regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.51046948
95DNA replication checkpoint (GO:0000076)3.49836014
96electron transport chain (GO:0022900)3.48805920
97meiotic cell cycle process (GO:1903046)3.47502118
98chaperone-mediated protein complex assembly (GO:0051131)3.43650466
99mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43115435
100mitochondrial respiratory chain complex I assembly (GO:0032981)3.43115435
101NADH dehydrogenase complex assembly (GO:0010257)3.43115435
102ventricular system development (GO:0021591)3.42645831
103ribosomal large subunit biogenesis (GO:0042273)3.42074726
104rRNA methylation (GO:0031167)3.41858126
105DNA catabolic process, exonucleolytic (GO:0000738)3.41401110
106regulation of ubiquitin-protein transferase activity (GO:0051438)3.41183848
107regulation of mitochondrial translation (GO:0070129)3.40225146
108DNA replication-dependent nucleosome assembly (GO:0006335)3.37251429
109DNA replication-dependent nucleosome organization (GO:0034723)3.37251429
110regulation of microtubule-based movement (GO:0060632)3.36044870
111organic cation transport (GO:0015695)3.34344300
112microtubule severing (GO:0051013)3.34130848
113formation of translation preinitiation complex (GO:0001731)3.33988420
114nuclear pore complex assembly (GO:0051292)3.33951306
115GTP biosynthetic process (GO:0006183)3.33304443
116regulation of centriole replication (GO:0046599)3.32307145
117mitotic metaphase plate congression (GO:0007080)3.32289121
118nucleobase biosynthetic process (GO:0046112)3.31580413
119regulation of helicase activity (GO:0051095)3.30668004
120DNA replication-independent nucleosome organization (GO:0034724)3.30503971
121DNA replication-independent nucleosome assembly (GO:0006336)3.30503971
122DNA deamination (GO:0045006)3.30028380
123multicellular organismal reproductive process (GO:0048609)3.29714937
124regulation of ligase activity (GO:0051340)3.29282470
125pseudouridine synthesis (GO:0001522)3.23879519
126protein localization to mitochondrion (GO:0070585)3.22858105
127histone mRNA metabolic process (GO:0008334)3.22047463
128establishment of viral latency (GO:0019043)3.20835064
129protein localization to cilium (GO:0061512)3.20602847
130oxidative phosphorylation (GO:0006119)3.20468511
131spermatid nucleus differentiation (GO:0007289)3.20154740
132establishment of protein localization to mitochondrion (GO:0072655)3.19684556
133synapsis (GO:0007129)3.19027152
134peptidyl-histidine modification (GO:0018202)3.16172137
135maturation of 5.8S rRNA (GO:0000460)3.14236260
136cytochrome complex assembly (GO:0017004)3.13249598
137intraciliary transport (GO:0042073)3.13073652
138IMP metabolic process (GO:0046040)3.12933448
139UTP biosynthetic process (GO:0006228)3.11407323
140water-soluble vitamin biosynthetic process (GO:0042364)3.11074237
141spliceosomal snRNP assembly (GO:0000387)3.10286727
142tRNA aminoacylation for protein translation (GO:0006418)3.09012501
143tRNA aminoacylation (GO:0043039)3.08208229
144amino acid activation (GO:0043038)3.08208229
145cell recognition (GO:0008037)3.07567002
146metaphase plate congression (GO:0051310)3.06745094
147protein refolding (GO:0042026)3.06571922
148centriole assembly (GO:0098534)3.04324673
149G1/S transition of mitotic cell cycle (GO:0000082)3.04242829
150cell cycle G1/S phase transition (GO:0044843)3.04242829
151single strand break repair (GO:0000012)3.03907583
152pteridine-containing compound biosynthetic process (GO:0042559)3.02999683
153mitochondrial RNA metabolic process (GO:0000959)3.02853232
154glycerol ether metabolic process (GO:0006662)3.02357165
155nuclear pore organization (GO:0006999)3.02181073
156DNA ligation (GO:0006266)3.01407228
157RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00077226
158tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00077226
159mitotic sister chromatid segregation (GO:0000070)2.99968818
160folic acid-containing compound biosynthetic process (GO:0009396)2.99414628
161chromatin remodeling at centromere (GO:0031055)2.99014429
162ribosomal small subunit assembly (GO:0000028)2.98936427
163rRNA processing (GO:0006364)2.98508591
164DNA strand elongation involved in DNA replication (GO:0006271)2.98438252
165nucleoside diphosphate phosphorylation (GO:0006165)2.98293805
166negative regulation of DNA-dependent DNA replication (GO:2000104)2.96698033
167transcription from mitochondrial promoter (GO:0006390)2.96621647
168DNA replication initiation (GO:0006270)2.96181113
169negative regulation of protein ubiquitination (GO:0031397)2.95568098
170calcium ion-dependent exocytosis (GO:0017156)2.95260482
171mitotic spindle checkpoint (GO:0071174)2.94186015
172guanosine-containing compound biosynthetic process (GO:1901070)2.94008741
173spindle checkpoint (GO:0031577)2.93827534
174negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93516349
175gene silencing by RNA (GO:0031047)2.93139634
176regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.91221764
177translesion synthesis (GO:0019985)2.89367109
178DNA strand elongation (GO:0022616)2.87671192
179microtubule polymerization or depolymerization (GO:0031109)2.87607588
180sequestering of actin monomers (GO:0042989)2.86850042
181ether metabolic process (GO:0018904)2.85221209
182protein polyglutamylation (GO:0018095)2.85115881
183histone H2A acetylation (GO:0043968)2.82997798
184chromosome organization (GO:0051276)2.81989207
185centriole replication (GO:0007099)2.79824283
186sister chromatid cohesion (GO:0007062)2.79436539
187attachment of spindle microtubules to kinetochore (GO:0008608)2.78874740
188nucleus organization (GO:0006997)2.77885060
189regulation of histone H3-K9 methylation (GO:0051570)2.77303637
190meiotic chromosome segregation (GO:0045132)2.77076277
191telomere maintenance via semi-conservative replication (GO:0032201)2.76810702
192regulation of centrosome cycle (GO:0046605)2.72867807
193pore complex assembly (GO:0046931)2.72810842
194CENP-A containing nucleosome assembly (GO:0034080)2.71736254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.64970292
2E2F7_22180533_ChIP-Seq_HELA_Human5.38636382
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.24130594
4E2F4_17652178_ChIP-ChIP_JURKAT_Human2.94215712
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.93688695
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72749013
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66108039
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42358704
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41593739
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.37265599
11* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.36062552
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35418772
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.35160249
14EZH2_22144423_ChIP-Seq_EOC_Human2.18015719
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.16534646
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.15512921
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07664722
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07104093
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99578265
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98631819
21* ETS1_20019798_ChIP-Seq_JURKAT_Human1.90810803
22* VDR_23849224_ChIP-Seq_CD4+_Human1.86620360
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77242962
24ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72005526
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69288013
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66005741
27* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60504586
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59624697
29MYC_18940864_ChIP-ChIP_HL60_Human1.57491466
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56419858
31* FOXP3_21729870_ChIP-Seq_TREG_Human1.55886389
32GABP_19822575_ChIP-Seq_HepG2_Human1.54745375
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51923057
34DCP1A_22483619_ChIP-Seq_HELA_Human1.49359421
35XRN2_22483619_ChIP-Seq_HELA_Human1.48516245
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.47852337
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46435158
38EWS_26573619_Chip-Seq_HEK293_Human1.45948830
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45290363
40AR_21909140_ChIP-Seq_LNCAP_Human1.40073139
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39284356
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.38777258
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.38191667
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.34487433
45FUS_26573619_Chip-Seq_HEK293_Human1.31779570
46* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31353211
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30794331
48ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.30346593
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.30038016
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30004918
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29576362
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28965022
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26699971
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25712154
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24859780
56TTF2_22483619_ChIP-Seq_HELA_Human1.24605409
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22009370
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21926688
59SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20696238
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19568892
61* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16915662
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16278625
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15425257
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.14980218
65KAP1_22055183_ChIP-Seq_ESCs_Mouse1.14387740
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.14247332
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.11579637
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10522084
69GATA3_21867929_ChIP-Seq_CD8_Mouse1.07796781
70IGF1R_20145208_ChIP-Seq_DFB_Human1.07037733
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06682049
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.05409111
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05286220
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04578725
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04343833
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03576046
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02637373
78ELK1_19687146_ChIP-ChIP_HELA_Human1.02607024
79TFEB_21752829_ChIP-Seq_HELA_Human1.02473457
80FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00967792
81SOX2_22085726_ChIP-Seq_NPCs_Mouse1.00585629
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99718018
83KDM5A_27292631_Chip-Seq_BREAST_Human0.98382282
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98310023
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97075981
86HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96226645
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95478901
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94702078
89ZNF274_21170338_ChIP-Seq_K562_Hela0.94494477
90VDR_22108803_ChIP-Seq_LS180_Human0.93206941
91YY1_22570637_ChIP-Seq_MALME-3M_Human0.92810547
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92207152
93FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91664765
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90910747
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90554794
96SOX17_20123909_ChIP-Seq_XEN_Mouse0.89988327
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89756991
98E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88895014
99ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87217409
100STAT1_17558387_ChIP-Seq_HELA_Human0.86996479
101STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86696947
102POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85637506
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85398766
104EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85149514
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84923043
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84579335
107CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84161036
108ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83178746
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.82711100
110ELK4_26923725_Chip-Seq_MESODERM_Mouse0.82583410
111ERG_20517297_ChIP-Seq_VCAP_Human0.82577454
112SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82343485
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81643554
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81184151
115ELF5_23300383_ChIP-Seq_T47D_Human0.80868635
116* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80860568
117MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.80709035
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80603107
119SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80041245
120WDR5_24793694_ChIP-Seq_LNCAP_Human0.79493250
121E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.78836898
122CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.78660578
123PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78425760
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78269344
125FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76976618
126TP53_22573176_ChIP-Seq_HFKS_Human0.75734944
127P300_19829295_ChIP-Seq_ESCs_Human0.74026322
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71371980
129SALL4_22934838_ChIP-ChIP_CD34+_Human0.71274420
130TAF15_26573619_Chip-Seq_HEK293_Human0.70766363
131SOX2_18555785_ChIP-Seq_MESCs_Mouse0.69780963
132FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.69180925

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.69656208
2MP0001929_abnormal_gametogenesis4.64517690
3MP0003698_abnormal_male_reproductive4.58629226
4MP0010094_abnormal_chromosome_stability3.59238010
5MP0003806_abnormal_nucleotide_metabolis3.53981917
6MP0008057_abnormal_DNA_replication3.51540223
7MP0002210_abnormal_sex_determination3.46069590
8MP0003693_abnormal_embryo_hatching3.27060847
9MP0008058_abnormal_DNA_repair3.11182991
10MP0003111_abnormal_nucleus_morphology3.04475600
11MP0009697_abnormal_copulation2.97923087
12MP0001145_abnormal_male_reproductive2.86952687
13MP0003077_abnormal_cell_cycle2.75911146
14MP0003186_abnormal_redox_activity2.63514106
15MP0002161_abnormal_fertility/fecundity2.60615696
16MP0008007_abnormal_cellular_replicative2.52476764
17MP0000653_abnormal_sex_gland2.52332064
18MP0003941_abnormal_skin_development2.47152101
19MP0004957_abnormal_blastocyst_morpholog2.46238922
20MP0002160_abnormal_reproductive_system2.10146872
21MP0005410_abnormal_fertilization11.0367296
22MP0006072_abnormal_retinal_apoptosis1.97634540
23MP0003786_premature_aging1.95840027
24MP0002653_abnormal_ependyma_morphology1.93359220
25MP0005084_abnormal_gallbladder_morpholo1.90261389
26MP0004147_increased_porphyrin_level1.72092565
27MP0008932_abnormal_embryonic_tissue1.58052518
28MP0000372_irregular_coat_pigmentation1.55281666
29MP0004808_abnormal_hematopoietic_stem1.53934293
30MP0010307_abnormal_tumor_latency1.51015511
31MP0001545_abnormal_hematopoietic_system1.50974451
32MP0005397_hematopoietic_system_phenotyp1.50974451
33MP0003195_calcinosis1.49071122
34MP0003646_muscle_fatigue1.47890214
35MP0003890_abnormal_embryonic-extraembry1.47079777
36MP0002938_white_spotting1.43005192
37MP0006292_abnormal_olfactory_placode1.40690435
38MP0003567_abnormal_fetal_cardiomyocyte1.36646547
39MP0001730_embryonic_growth_arrest1.32130671
40MP0002396_abnormal_hematopoietic_system1.26366292
41MP0005389_reproductive_system_phenotype1.25694331
42MP0008995_early_reproductive_senescence1.25489452
43MP0002090_abnormal_vision1.22691448
44MP0004215_abnormal_myocardial_fiber1.21444654
45MP0002837_dystrophic_cardiac_calcinosis1.21416192
46MP0000350_abnormal_cell_proliferation1.19180842
47MP0003011_delayed_dark_adaptation1.10018362
48MP0008789_abnormal_olfactory_epithelium1.09556543
49MP0000313_abnormal_cell_death1.09086155
50MP0005253_abnormal_eye_physiology1.06934500
51MP0003787_abnormal_imprinting1.04421329
52MP0008872_abnormal_physiological_respon1.04305891
53MP0001188_hyperpigmentation1.03965907
54MP0000358_abnormal_cell_content/1.03708232
55MP0003123_paternal_imprinting1.00854870
56MP0003763_abnormal_thymus_physiology0.98734865
57MP0005395_other_phenotype0.96691888
58MP0005332_abnormal_amino_acid0.95113130
59MP0000647_abnormal_sebaceous_gland0.91960446
60MP0002019_abnormal_tumor_incidence0.91668008
61MP0002398_abnormal_bone_marrow0.89748651
62MP0001697_abnormal_embryo_size0.88870978
63MP0005408_hypopigmentation0.88573012
64MP0001119_abnormal_female_reproductive0.87763189
65MP0005379_endocrine/exocrine_gland_phen0.86328134
66MP0002282_abnormal_trachea_morphology0.86158065
67MP0000015_abnormal_ear_pigmentation0.85313804
68MP0002080_prenatal_lethality0.85051734
69MP0001672_abnormal_embryogenesis/_devel0.84413390
70MP0005380_embryogenesis_phenotype0.84413390
71MP0000490_abnormal_crypts_of0.84177845
72MP0000703_abnormal_thymus_morphology0.82511742
73MP0006036_abnormal_mitochondrial_physio0.81896824
74MP0003121_genomic_imprinting0.81549105
75MP0003718_maternal_effect0.80208888
76MP0002102_abnormal_ear_morphology0.78626995
77MP0009046_muscle_twitch0.77462576
78MP0003950_abnormal_plasma_membrane0.76574369
79MP0001984_abnormal_olfaction0.76330227
80MP0005551_abnormal_eye_electrophysiolog0.74813906
81MP0009379_abnormal_foot_pigmentation0.74154145
82MP0001881_abnormal_mammary_gland0.72526638
83MP0003984_embryonic_growth_retardation0.71683227
84MP0003122_maternal_imprinting0.69929893
85MP0003937_abnormal_limbs/digits/tail_de0.68484025
86MP0002132_abnormal_respiratory_system0.66833072
87MP0000689_abnormal_spleen_morphology0.66675461
88MP0005266_abnormal_metabolism0.66483535
89MP0002088_abnormal_embryonic_growth/wei0.66383785
90MP0006035_abnormal_mitochondrial_morpho0.65355784
91MP0008875_abnormal_xenobiotic_pharmacok0.64886764
92MP0001727_abnormal_embryo_implantation0.64775900
93MP0008873_increased_physiological_sensi0.64481430
94MP0002722_abnormal_immune_system0.64409534
95MP0002085_abnormal_embryonic_tissue0.63426229
96MP0002084_abnormal_developmental_patter0.63244151
97MP0003315_abnormal_perineum_morphology0.63196296
98MP0001529_abnormal_vocalization0.62963274
99MP0009333_abnormal_splenocyte_physiolog0.62750308
100MP0005670_abnormal_white_adipose0.62452802
101MP0005075_abnormal_melanosome_morpholog0.61810637
102MP0009672_abnormal_birth_weight0.60522736
103MP0002429_abnormal_blood_cell0.60474895
104MP0002405_respiratory_system_inflammati0.59654788
105MP0001835_abnormal_antigen_presentation0.58234757
106MP0003119_abnormal_digestive_system0.57410430
107MP0003699_abnormal_female_reproductive0.56791103
108MP0005645_abnormal_hypothalamus_physiol0.56738707
109MP0005220_abnormal_exocrine_pancreas0.56642445
110MP0005394_taste/olfaction_phenotype0.56379237
111MP0005499_abnormal_olfactory_system0.56379237
112MP0000716_abnormal_immune_system0.55767853
113MP0005187_abnormal_penis_morphology0.54761669
114MP0000516_abnormal_urinary_system0.54530509
115MP0005174_abnormal_tail_pigmentation0.53977059
116MP0002095_abnormal_skin_pigmentation0.53531710
117MP0001293_anophthalmia0.53059822
118MP0005671_abnormal_response_to0.51969968
119MP0006054_spinal_hemorrhage0.51819842
120MP0001919_abnormal_reproductive_system0.50639726
121MP0004197_abnormal_fetal_growth/weight/0.50495926
122MP0001986_abnormal_taste_sensitivity0.48657122
123MP0004233_abnormal_muscle_weight0.48048169
124MP0002420_abnormal_adaptive_immunity0.46887418
125MP0001764_abnormal_homeostasis0.46428780
126MP0001819_abnormal_immune_cell0.45545056
127MP0005384_cellular_phenotype0.45060558
128MP0005623_abnormal_meninges_morphology0.44677452
129MP0009278_abnormal_bone_marrow0.43075010
130MP0005647_abnormal_sex_gland0.42874527
131MP0002723_abnormal_immune_serum0.42668530
132MP0002163_abnormal_gland_morphology0.42080514
133MP0003943_abnormal_hepatobiliary_system0.41716716
134MP0003115_abnormal_respiratory_system0.41127361
135MP0000858_altered_metastatic_potential0.41056880
136MP0002736_abnormal_nociception_after0.40665950
137MP0002086_abnormal_extraembryonic_tissu0.40402524
138MP0005636_abnormal_mineral_homeostasis0.39864505
139MP0001765_abnormal_ion_homeostasis0.36798778
140MP0001800_abnormal_humoral_immune0.36722194
141MP0001853_heart_inflammation0.36189203
142MP0002452_abnormal_antigen_presenting0.35678036
143MP0005646_abnormal_pituitary_gland0.34670864
144MP0002169_no_abnormal_phenotype0.33692835

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.88831313
2Abnormal respiratory epithelium morphology (HP:0012253)7.87839718
3Abnormal respiratory motile cilium morphology (HP:0005938)7.87839718
4Rhinitis (HP:0012384)6.83472847
5Abnormal ciliary motility (HP:0012262)6.29064015
6Chronic bronchitis (HP:0004469)6.23381171
7Infertility (HP:0000789)5.59557317
8Nasal polyposis (HP:0100582)5.31090393
9Acute necrotizing encephalopathy (HP:0006965)4.93942682
10Acute encephalopathy (HP:0006846)4.63841003
11Abnormal mitochondria in muscle tissue (HP:0008316)4.38582675
12Nephronophthisis (HP:0000090)4.24221585
13Increased hepatocellular lipid droplets (HP:0006565)4.23741937
14Progressive macrocephaly (HP:0004481)4.20891533
15Mitochondrial inheritance (HP:0001427)4.20588223
16Abnormality of the nasal mucosa (HP:0000433)4.17453573
17Increased CSF lactate (HP:0002490)4.15561516
18Bronchitis (HP:0012387)4.13440674
19Bronchiectasis (HP:0002110)4.12903968
20Lipid accumulation in hepatocytes (HP:0006561)3.81725260
21Hepatocellular necrosis (HP:0001404)3.72534685
22Abnormal spermatogenesis (HP:0008669)3.58806135
23Cerebral edema (HP:0002181)3.55788251
24Renal Fanconi syndrome (HP:0001994)3.50393770
25Hepatic necrosis (HP:0002605)3.49014525
26Abnormality of methionine metabolism (HP:0010901)3.20145434
27Methylmalonic acidemia (HP:0002912)3.17101427
28Increased serum lactate (HP:0002151)3.09627457
29Abnormality of the renal medulla (HP:0100957)3.07700111
30Male infertility (HP:0003251)3.07542843
31Abnormality of the anterior horn cell (HP:0006802)3.03153375
32Degeneration of anterior horn cells (HP:0002398)3.03153375
33Recurrent sinusitis (HP:0011108)3.01605621
34Hypoplasia of the capital femoral epiphysis (HP:0003090)2.99600712
35Decreased activity of mitochondrial respiratory chain (HP:0008972)2.96254987
36Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.96254987
37Recurrent otitis media (HP:0000403)2.95424528
38Impulsivity (HP:0100710)2.94604852
39Lactic acidosis (HP:0003128)2.94000708
40Type I transferrin isoform profile (HP:0003642)2.93071151
41Gonadotropin excess (HP:0000837)2.92766600
42Abnormality of midbrain morphology (HP:0002418)2.90976642
43Molar tooth sign on MRI (HP:0002419)2.90976642
44Increased serum pyruvate (HP:0003542)2.85877168
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81053146
46Abnormality of alanine metabolism (HP:0010916)2.81053146
47Hyperalaninemia (HP:0003348)2.81053146
48Medial flaring of the eyebrow (HP:0010747)2.78154743
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.73591674
50Recurrent bronchitis (HP:0002837)2.73480342
51Exertional dyspnea (HP:0002875)2.72768052
52Colon cancer (HP:0003003)2.71338587
53Abnormality of serum amino acid levels (HP:0003112)2.70871445
54Methylmalonic aciduria (HP:0012120)2.66518411
55Abnormality of glycolysis (HP:0004366)2.64177818
56Abnormality of the labia minora (HP:0012880)2.62222084
57Respiratory failure (HP:0002878)2.60304532
58Abnormal glycosylation (HP:0012345)2.59511873
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.59511873
60Abnormal protein N-linked glycosylation (HP:0012347)2.59511873
61Abnormal protein glycosylation (HP:0012346)2.59511873
62Reduced antithrombin III activity (HP:0001976)2.59377756
63Tubulointerstitial nephritis (HP:0001970)2.55160789
64Increased intramyocellular lipid droplets (HP:0012240)2.53998270
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.47938566
66Microvesicular hepatic steatosis (HP:0001414)2.46629004
673-Methylglutaconic aciduria (HP:0003535)2.44897752
68Amyotrophic lateral sclerosis (HP:0007354)2.43723143
69Lethargy (HP:0001254)2.43338155
70Respiratory difficulties (HP:0002880)2.41331572
71Exercise intolerance (HP:0003546)2.41075164
72Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.36414833
73Absent epiphyses (HP:0010577)2.36414833
74Azoospermia (HP:0000027)2.36292247
75Leukodystrophy (HP:0002415)2.34477287
76Macrocytic anemia (HP:0001972)2.33981295
77Multiple enchondromatosis (HP:0005701)2.32073413
7811 pairs of ribs (HP:0000878)2.31374605
79Megaloblastic anemia (HP:0001889)2.31341335
80Hyperglycinemia (HP:0002154)2.31087385
81Abnormality of the lower motor neuron (HP:0002366)2.29604203
82Pancreatic fibrosis (HP:0100732)2.29337800
83Pancreatic islet-cell hyperplasia (HP:0004510)2.26484687
84Abnormal lung lobation (HP:0002101)2.24405321
85Postaxial foot polydactyly (HP:0001830)2.22438420
86Reticulocytopenia (HP:0001896)2.20196805
87Tubular atrophy (HP:0000092)2.17920880
88Cerebral hypomyelination (HP:0006808)2.17910215
89Optic disc pallor (HP:0000543)2.17671071
90CNS demyelination (HP:0007305)2.17244389
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15220955
92Facial cleft (HP:0002006)2.12882424
93Hypoglycemic coma (HP:0001325)2.12008255
94Fibular hypoplasia (HP:0003038)2.06949457
95Pancytopenia (HP:0001876)2.06407990
96Sloping forehead (HP:0000340)2.06269140
97Abnormal number of erythroid precursors (HP:0012131)2.06118752
98Abnormality of renal resorption (HP:0011038)2.05658529
99True hermaphroditism (HP:0010459)2.02441649
100Abnormality of cells of the erythroid lineage (HP:0012130)2.02205815
101Neoplasm of the adrenal gland (HP:0100631)2.01795322
102Hypoglycemic seizures (HP:0002173)2.01149051
103Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.8797089
104Dynein arm defect of respiratory motile cilia (HP:0012255)10.6247471
105Absent/shortened dynein arms (HP:0200106)10.6247471
106Abnormality of the preputium (HP:0100587)1.99837186
107Oculomotor apraxia (HP:0000657)1.99123802
108Birth length less than 3rd percentile (HP:0003561)1.98613718
109Abnormality of sulfur amino acid metabolism (HP:0004339)1.98508593
110Hyperinsulinemic hypoglycemia (HP:0000825)1.98099123
111Supernumerary spleens (HP:0009799)1.97962795
112Abnormality of urine glucose concentration (HP:0011016)1.95637614
113Glycosuria (HP:0003076)1.95637614
114Abnormality of homocysteine metabolism (HP:0010919)1.94740080
115Homocystinuria (HP:0002156)1.94740080
116Generalized aminoaciduria (HP:0002909)1.92454809
117Increased muscle lipid content (HP:0009058)1.91916688
118Abnormality of the vitamin B12 metabolism (HP:0004341)1.91620304
119Abnormality of vitamin B metabolism (HP:0004340)1.90884106
120Hypothermia (HP:0002045)1.89816187
121Abnormality of the duodenum (HP:0002246)1.89789308
122Aplasia/Hypoplasia of the uvula (HP:0010293)1.87690176
123Selective tooth agenesis (HP:0001592)1.87061081
124Sensory axonal neuropathy (HP:0003390)1.86436538
125Pancreatic cysts (HP:0001737)1.84487502
126Postnatal microcephaly (HP:0005484)1.83717474
127Oral leukoplakia (HP:0002745)1.83493175
128Volvulus (HP:0002580)1.82872335
129Chronic sinusitis (HP:0011109)1.82785687
130Abnormality of chromosome stability (HP:0003220)1.82256754
131Tubulointerstitial abnormality (HP:0001969)1.82234961
132Abnormality of glycine metabolism (HP:0010895)1.80814161
133Abnormality of serine family amino acid metabolism (HP:0010894)1.80814161
134Meckel diverticulum (HP:0002245)1.80508813
135Stenosis of the external auditory canal (HP:0000402)1.79314453
136Congenital, generalized hypertrichosis (HP:0004540)1.78025246
137X-linked dominant inheritance (HP:0001423)1.77755432
138Atrophy/Degeneration involving motor neurons (HP:0007373)1.77692730
139Congenital hepatic fibrosis (HP:0002612)1.76930250
140Congenital primary aphakia (HP:0007707)1.76129061
141Hyperglycinuria (HP:0003108)1.75382491
142Impaired proprioception (HP:0010831)1.73242522
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.71819694
144Abnormality of the ileum (HP:0001549)1.71736123
145Chromsome breakage (HP:0040012)1.71702225
146Sparse eyelashes (HP:0000653)1.70098960
147Short ribs (HP:0000773)1.67724067
148Chromosomal breakage induced by crosslinking agents (HP:0003221)1.67430473
149Aplastic anemia (HP:0001915)1.67243987
150Gait imbalance (HP:0002141)1.65154413
151Nephrogenic diabetes insipidus (HP:0009806)1.63438945
152Median cleft lip (HP:0000161)1.62425055
153Cystic liver disease (HP:0006706)1.60400346
154Small intestinal stenosis (HP:0012848)1.58613316
155Duodenal stenosis (HP:0100867)1.58613316
156Postaxial hand polydactyly (HP:0001162)1.57752266
157Cleft eyelid (HP:0000625)1.56801558
158Carpal bone hypoplasia (HP:0001498)1.52974353
159Myelodysplasia (HP:0002863)1.52697565
160Agnosia (HP:0010524)1.51469813
161Type 2 muscle fiber atrophy (HP:0003554)1.51438470
162Upper motor neuron abnormality (HP:0002127)1.48169002
163Broad distal phalanx of finger (HP:0009836)1.47338565
164Ectopic kidney (HP:0000086)1.47229178
165Absent thumb (HP:0009777)1.45233075
166Anencephaly (HP:0002323)1.44049719
167Bone marrow hypocellularity (HP:0005528)1.40735964
168Muscle fiber atrophy (HP:0100295)1.38791187
169Stage 5 chronic kidney disease (HP:0003774)1.38571548
170Nephroblastoma (Wilms tumor) (HP:0002667)1.37992372
171Renal dysplasia (HP:0000110)1.37811814
172Breast carcinoma (HP:0003002)1.36716310
173Short femoral neck (HP:0100864)1.36494324
174Abnormality of the renal cortex (HP:0011035)1.36305819
175Poor coordination (HP:0002370)1.36218422
176Preaxial hand polydactyly (HP:0001177)1.33303417
177Sclerocornea (HP:0000647)1.33207792
178Personality changes (HP:0000751)1.32651077
179Pulmonary fibrosis (HP:0002206)1.32473151
180Abnormality of dentin (HP:0010299)1.31352863
181Clubbing of toes (HP:0100760)1.31311597
182Microglossia (HP:0000171)1.29933873
183Constricted visual fields (HP:0001133)1.29756683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.97952153
2PDK46.97952153
3TESK14.91183323
4PDK24.43670272
5MST43.29593399
6CDC73.09189982
7PBK3.08582521
8VRK22.98951034
9PRKD32.88041969
10NEK22.87975229
11BUB12.77020153
12WEE12.74670124
13TRIM282.41066872
14CCNB12.40690633
15NUAK12.10974063
16ICK2.09970682
17PNCK1.99614496
18MAP3K121.91486201
19EIF2AK11.85493000
20DYRK31.79615646
21PLK41.78217825
22PASK1.76332345
23MAP4K21.66917400
24STK161.62489148
25PTK2B1.58270239
26TAF11.50957958
27NME11.50910105
28WNK31.45744521
29BRSK21.44322492
30TTK1.34112467
31EIF2AK31.32098996
32TESK21.31801112
33ACVR1B1.31759400
34SRPK11.31479643
35VRK11.23971824
36ATR1.23379039
37PLK11.20608214
38TNIK1.16474962
39CHEK21.14634477
40ERBB31.09404045
41BCR1.08982746
42CSNK1G11.04876220
43CSNK1G31.02997162
44BRSK10.99655220
45SCYL20.98989336
46CHEK10.93200253
47CSNK1G20.93127902
48BCKDK0.88428428
49WNK40.86810932
50AURKB0.86693184
51PLK30.81867299
52DYRK1B0.80254417
53TSSK60.78355147
54CSNK1A1L0.71430644
55AURKA0.70889174
56FRK0.69175091
57STK30.68071553
58MAP4K10.67257424
59ATM0.66455237
60RPS6KA40.65801954
61GRK10.64919469
62MKNK10.64790271
63CDK70.64063669
64OXSR10.61989804
65CLK10.60226251
66ALK0.58758654
67PIM20.57396733
68PAK10.56771236
69STK100.55970618
70TLK10.55397433
71NME20.53034474
72BMPR20.51088038
73STK380.50999090
74BMPR1B0.50508984
75CDK40.48744312
76MKNK20.48547066
77NEK10.48496647
78FLT30.48251990
79ERBB40.48238498
80MAPK150.48044210
81CSNK2A10.47295231
82INSRR0.47242734
83CDK80.47114945
84BRAF0.47052877
85PIM10.46677671
86ZAP700.46591574
87ZAK0.44857332
88STK390.44074068
89EEF2K0.42662254
90PDK10.42464825
91MYLK0.41036344
92LIMK10.40832640
93CSNK1E0.40304527
94CDK20.39674684
95MAP3K40.38301282
96CSNK2A20.37688541
97MUSK0.36927735
98TGFBR10.36798877
99STK40.35778729
100ADRBK20.35752591
101PAK40.35159989
102DAPK10.34949251
103IRAK10.34713121
104MAP3K100.34188339
105ILK0.33056041
106MAP2K60.32511301
107CDK10.32462195
108CDK190.32432500
109ABL20.30940298
110PRKCI0.30440240
111CDK60.30299003
112STK240.30041484
113CSNK1A10.28521144
114EIF2AK20.27970767
115MINK10.27269879
116MAP3K50.27006265
117YES10.25996557
118MAP2K70.25449076
119RPS6KB10.24316447
120CDK30.21822454
121MAP3K60.20943247
122KIT0.20443441
123MAP3K80.18045958
124MAPKAPK50.17532547
125BTK0.17324644
126CDK180.17310710
127TEC0.16913574
128TXK0.16070876
129RPS6KB20.15706582
130STK38L0.15552998
131SYK0.15514522
132PLK20.15419564
133CSF1R0.15174277
134CDK11A0.15129610
135RPS6KA50.14929715
136CDK150.14902153
137PRKCG0.14115455
138MARK30.11633066
139IRAK40.08612570
140DYRK20.08244070

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.31177848
2Proteasome_Homo sapiens_hsa030503.46709172
3Mismatch repair_Homo sapiens_hsa034303.29351871
4Fanconi anemia pathway_Homo sapiens_hsa034603.02897691
5RNA transport_Homo sapiens_hsa030133.00228584
6Vitamin B6 metabolism_Homo sapiens_hsa007502.94197542
7Homologous recombination_Homo sapiens_hsa034402.89955634
8Spliceosome_Homo sapiens_hsa030402.86906410
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.76361832
10* Basal transcription factors_Homo sapiens_hsa030222.72951557
11Base excision repair_Homo sapiens_hsa034102.65888199
12RNA polymerase_Homo sapiens_hsa030202.58767289
13Pyrimidine metabolism_Homo sapiens_hsa002402.52158670
14Cell cycle_Homo sapiens_hsa041102.49255286
15Nucleotide excision repair_Homo sapiens_hsa034202.47630506
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.06707859
17Ribosome_Homo sapiens_hsa030101.95840019
18RNA degradation_Homo sapiens_hsa030181.95078293
19mRNA surveillance pathway_Homo sapiens_hsa030151.91897192
20Huntingtons disease_Homo sapiens_hsa050161.90467039
21Purine metabolism_Homo sapiens_hsa002301.85712158
22Pyruvate metabolism_Homo sapiens_hsa006201.76798029
23Non-homologous end-joining_Homo sapiens_hsa034501.73253928
24Oocyte meiosis_Homo sapiens_hsa041141.69626960
25Fatty acid elongation_Homo sapiens_hsa000621.67379676
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64146317
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58564271
28Pentose phosphate pathway_Homo sapiens_hsa000301.45197099
29Systemic lupus erythematosus_Homo sapiens_hsa053221.45188177
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40799937
31Antigen processing and presentation_Homo sapiens_hsa046121.40025822
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.34332626
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34269888
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34032446
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29283806
36Protein export_Homo sapiens_hsa030601.27544834
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27158227
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26028908
39Selenocompound metabolism_Homo sapiens_hsa004501.25566853
40Epstein-Barr virus infection_Homo sapiens_hsa051691.22568852
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.19529900
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14885165
43p53 signaling pathway_Homo sapiens_hsa041151.14652412
44Oxidative phosphorylation_Homo sapiens_hsa001901.12935406
45Folate biosynthesis_Homo sapiens_hsa007901.12799118
46Glucagon signaling pathway_Homo sapiens_hsa049221.09430185
47Parkinsons disease_Homo sapiens_hsa050121.07688130
48Sulfur metabolism_Homo sapiens_hsa009200.97519290
49Steroid biosynthesis_Homo sapiens_hsa001000.96915320
50Linoleic acid metabolism_Homo sapiens_hsa005910.96288925
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96214749
52Viral carcinogenesis_Homo sapiens_hsa052030.90991028
53Legionellosis_Homo sapiens_hsa051340.87712487
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87213609
55Alcoholism_Homo sapiens_hsa050340.86585887
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86361233
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83786003
58Butanoate metabolism_Homo sapiens_hsa006500.82579342
59One carbon pool by folate_Homo sapiens_hsa006700.82464057
60N-Glycan biosynthesis_Homo sapiens_hsa005100.82384860
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81585720
62Fatty acid biosynthesis_Homo sapiens_hsa000610.78507544
63Peroxisome_Homo sapiens_hsa041460.77131968
64Fatty acid metabolism_Homo sapiens_hsa012120.76764811
65Regulation of autophagy_Homo sapiens_hsa041400.76310131
66Herpes simplex infection_Homo sapiens_hsa051680.74504967
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73428302
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69608824
69Carbon metabolism_Homo sapiens_hsa012000.64519063
70Fructose and mannose metabolism_Homo sapiens_hsa000510.62895629
71Biosynthesis of amino acids_Homo sapiens_hsa012300.62038153
72Collecting duct acid secretion_Homo sapiens_hsa049660.60501562
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60296920
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59760485
75Alzheimers disease_Homo sapiens_hsa050100.58654912
76Amphetamine addiction_Homo sapiens_hsa050310.56022159
77Glutathione metabolism_Homo sapiens_hsa004800.55407859
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54504229
79HTLV-I infection_Homo sapiens_hsa051660.53402358
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.53356721
81Fatty acid degradation_Homo sapiens_hsa000710.52470436
82Propanoate metabolism_Homo sapiens_hsa006400.52420691
83Cardiac muscle contraction_Homo sapiens_hsa042600.52207502
84Nitrogen metabolism_Homo sapiens_hsa009100.49066384
85Arginine and proline metabolism_Homo sapiens_hsa003300.48710756
86Measles_Homo sapiens_hsa051620.46883109
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45931398
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.45399158
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45067845
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.44439240
91Phototransduction_Homo sapiens_hsa047440.41419380
92Vitamin digestion and absorption_Homo sapiens_hsa049770.40081599
93beta-Alanine metabolism_Homo sapiens_hsa004100.38292500
94Primary immunodeficiency_Homo sapiens_hsa053400.38142642
95Tryptophan metabolism_Homo sapiens_hsa003800.37265536
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37191448
97Arachidonic acid metabolism_Homo sapiens_hsa005900.36453671
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35815963
99Shigellosis_Homo sapiens_hsa051310.35518743
100Metabolic pathways_Homo sapiens_hsa011000.34993165
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34518407
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32431028
103Influenza A_Homo sapiens_hsa051640.31430755
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31196125
105Dorso-ventral axis formation_Homo sapiens_hsa043200.30077402
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.30015919
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.28560510
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27759057
109Asthma_Homo sapiens_hsa053100.27408442
110Chemical carcinogenesis_Homo sapiens_hsa052040.26509924
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26328690
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24460196
113Ether lipid metabolism_Homo sapiens_hsa005650.24207015
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24023260
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20063116
116Glycerolipid metabolism_Homo sapiens_hsa005610.19295298
117B cell receptor signaling pathway_Homo sapiens_hsa046620.19249858
118TGF-beta signaling pathway_Homo sapiens_hsa043500.19161230
119Sulfur relay system_Homo sapiens_hsa041220.19085965
120Phagosome_Homo sapiens_hsa041450.18690108
121Renin-angiotensin system_Homo sapiens_hsa046140.18318105
122Retinol metabolism_Homo sapiens_hsa008300.17372834
123Arginine biosynthesis_Homo sapiens_hsa002200.16561059
124Caffeine metabolism_Homo sapiens_hsa002320.16551947
125Hepatitis B_Homo sapiens_hsa051610.15301691
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15128714
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14794494
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14586861
129Vibrio cholerae infection_Homo sapiens_hsa051100.14211330
130T cell receptor signaling pathway_Homo sapiens_hsa046600.14152831
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13985496
132Fat digestion and absorption_Homo sapiens_hsa049750.13228762
133Tyrosine metabolism_Homo sapiens_hsa003500.12193630
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11172809
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.08697111
136Hematopoietic cell lineage_Homo sapiens_hsa046400.07948653
137Long-term potentiation_Homo sapiens_hsa047200.07188936
138HIF-1 signaling pathway_Homo sapiens_hsa040660.06379869
139VEGF signaling pathway_Homo sapiens_hsa043700.06156439
140Allograft rejection_Homo sapiens_hsa053300.05894452
141Hedgehog signaling pathway_Homo sapiens_hsa043400.05743235
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.05415925
143Other glycan degradation_Homo sapiens_hsa005110.04693819

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »