ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of action potential (GO:0045760)	8.28990265
2	aggressive behavior (GO:0002118)	7.59792381
3	positive regulation of vascular permeability (GO:0043117)	7.05753339
4	positive regulation of uterine smooth muscle contraction (GO:0070474)	6.98957736
5	urinary tract smooth muscle contraction (GO:0014848)	6.84480528
6	drinking behavior (GO:0042756)	5.57349063
7	regulation of uterine smooth muscle contraction (GO:0070472)	5.37696563
8	regulation of action potential (GO:0098900)	5.35958972
9	positive regulation of digestive system process (GO:0060456)	5.16281169
10	RNA destabilization (GO:0050779)	5.11442260
11	behavioral response to ethanol (GO:0048149)	5.00437256
12	behavioral response to pain (GO:0048266)	4.70957868
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.70674951
14	cilium or flagellum-dependent cell motility (GO:0001539)	4.60270256
15	diterpenoid biosynthetic process (GO:0016102)	4.56672174
16	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	4.03605818
17	terpenoid biosynthetic process (GO:0016114)	3.95603810
18	positive regulation of synaptic transmission, GABAergic (GO:0032230)	3.85422603
19	fusion of sperm to egg plasma membrane (GO:0007342)	3.66272763
20	neural tube formation (GO:0001841)	3.47853485
21	S-adenosylmethionine metabolic process (GO:0046500)	3.41264191
22	retinal cone cell development (GO:0046549)	3.40972133
23	regulation of cilium movement (GO:0003352)	3.40257790
24	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.35602988
25	establishment of protein localization to Golgi (GO:0072600)	3.35139458
26	response to auditory stimulus (GO:0010996)	3.28521627
27	axoneme assembly (GO:0035082)	3.26971358
28	pyrimidine nucleobase catabolic process (GO:0006208)	3.26633241
29	retinal metabolic process (GO:0042574)	3.24796771
30	negative regulation of digestive system process (GO:0060457)	3.21620693
31	cellular ketone body metabolic process (GO:0046950)	3.21316831
32	protein targeting to Golgi (GO:0000042)	3.19496459
33	negative regulation of meiosis (GO:0045835)	3.17655850
34	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.16429836
35	epithelial cilium movement (GO:0003351)	3.07149430
36	lung secretory cell differentiation (GO:0061140)	3.05823076
37	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.04459599
38	plasma membrane fusion (GO:0045026)	3.04328215
39	regulation of digestive system process (GO:0044058)	3.02161805
40	positive regulation of renal sodium excretion (GO:0035815)	2.99069067
41	regulation of energy homeostasis (GO:2000505)	2.96568779
42	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.94844916
43	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.93768026
44	detection of light stimulus involved in sensory perception (GO:0050962)	2.92939989
45	detection of light stimulus involved in visual perception (GO:0050908)	2.92939989
46	negative regulation of heart rate (GO:0010459)	2.89641369
47	positive regulation of vesicle fusion (GO:0031340)	2.87699248
48	behavioral response to nicotine (GO:0035095)	2.83666215
49	GPI anchor metabolic process (GO:0006505)	2.82072307
50	centriole replication (GO:0007099)	2.82032752
51	ketone body metabolic process (GO:1902224)	2.81066309
52	photoreceptor cell maintenance (GO:0045494)	2.80668059
53	response to pain (GO:0048265)	2.79783187
54	intestinal cholesterol absorption (GO:0030299)	2.78589643
55	behavioral defense response (GO:0002209)	2.78343005
56	behavioral fear response (GO:0001662)	2.78343005
57	lens fiber cell development (GO:0070307)	2.75844363
58	protein prenylation (GO:0018342)	2.72784344
59	prenylation (GO:0097354)	2.72784344
60	spermatid nucleus differentiation (GO:0007289)	2.72601257
61	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.71484010
62	cilium movement (GO:0003341)	2.69145723
63	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.68855798
64	regulation of synaptic transmission, GABAergic (GO:0032228)	2.67287506
65	ectoderm development (GO:0007398)	2.66903327
66	nucleobase catabolic process (GO:0046113)	2.65619382
67	nonmotile primary cilium assembly (GO:0035058)	2.65541172
68	single strand break repair (GO:0000012)	2.65047922
69	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.64277025
70	immunoglobulin mediated immune response (GO:0016064)	2.64088344
71	synapsis (GO:0007129)	2.61838987
72	negative regulation of appetite (GO:0032099)	2.60614812
73	negative regulation of response to food (GO:0032096)	2.60614812
74	eating behavior (GO:0042755)	2.59749143
75	protein localization to Golgi apparatus (GO:0034067)	2.59394854
76	positive regulation of growth hormone secretion (GO:0060124)	2.58724852
77	cornea development in camera-type eye (GO:0061303)	2.58516068
78	regulation of hexokinase activity (GO:1903299)	2.57535743
79	regulation of glucokinase activity (GO:0033131)	2.57535743
80	neuronal action potential (GO:0019228)	2.57297835
81	multicellular organismal response to stress (GO:0033555)	2.56852238
82	positive regulation of amino acid transport (GO:0051957)	2.56619141
83	L-methionine salvage (GO:0071267)	2.56481656
84	L-methionine biosynthetic process (GO:0071265)	2.56481656
85	amino acid salvage (GO:0043102)	2.56481656
86	histone H2A acetylation (GO:0043968)	2.56378507
87	righting reflex (GO:0060013)	2.54527552
88	regulation of renal sodium excretion (GO:0035813)	2.53708788
89	relaxation of smooth muscle (GO:0044557)	2.52219644
90	negative regulation of meiotic cell cycle (GO:0051447)	2.48533003
91	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.47889429
92	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.47498254
93	organelle disassembly (GO:1903008)	2.47132965
94	phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200)	2.45467373
95	adult feeding behavior (GO:0008343)	2.44056924
96	intraciliary transport (GO:0042073)	2.42650317
97	prostate gland growth (GO:0060736)	2.42160206
98	respiratory chain complex IV assembly (GO:0008535)	2.39907564
99	somite development (GO:0061053)	2.39805489
100	tachykinin receptor signaling pathway (GO:0007217)	10.4529432

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.99101390
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.31358658
3	VDR_22108803_ChIP-Seq_LS180_Human	3.11369711
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.96820311
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.86833145
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.75749844
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.62607716
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.58227201
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.36774977
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.36650698
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.33099726
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.29682066
13	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.24050352
14	CBP_20019798_ChIP-Seq_JUKART_Human	2.24050352
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.17915000
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.15725377
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.14797505
18	FUS_26573619_Chip-Seq_HEK293_Human	2.11010808
19	EWS_26573619_Chip-Seq_HEK293_Human	2.09951110
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.08002274
21	P300_19829295_ChIP-Seq_ESCs_Human	2.07590012
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.06483922
23	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.03980697
24	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.84042708
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.83341620
26	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.82831978
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.72610410
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70970300
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.67238601
30	AR_25329375_ChIP-Seq_VCAP_Human	1.67188646
31	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.66979588
32	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.63282688
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62732336
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.59299893
35	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.58932698
36	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.54273431
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52932742
38	STAT3_23295773_ChIP-Seq_U87_Human	1.49903489
39	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.48739705
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.46916535
41	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.46328874
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45478153
43	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.44615711
44	RNF2_27304074_Chip-Seq_NSC_Mouse	1.43252296
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.43023428
46	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.42313235
47	TCF4_23295773_ChIP-Seq_U87_Human	1.39757535
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38837805
49	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38678808
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.36851389
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.36851389
52	TCF4_22108803_ChIP-Seq_LS180_Human	1.36388371
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.36160229
54	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35998258
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35360159
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.34894136
57	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.34456197
58	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34302422
59	TP53_16413492_ChIP-PET_HCT116_Human	1.34273183
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33829141
61	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.33475410
62	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.32977642
63	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31780196
64	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.27776829
65	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.27684288
66	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26863132
67	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.24722687
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24137378
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.22571535
70	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.22237237
71	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21839444
72	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.21382861
73	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13506123
74	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13128256
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11574030
76	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.09560569
77	VDR_23849224_ChIP-Seq_CD4+_Human	1.08682136
78	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.07615556
79	CDX2_22108803_ChIP-Seq_LS180_Human	1.07420346
80	RXR_22108803_ChIP-Seq_LS180_Human	1.02149953
81	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01716149
82	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.01505928
83	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01334732
84	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.00657992
85	REST_21632747_ChIP-Seq_MESCs_Mouse	1.00003831
86	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.99924796
87	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99713615
88	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.99503326
89	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.99503326
90	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.99205793
91	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.99205793
92	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97306321
93	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96523324
94	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96506470
95	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.94093798
96	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.93887286
97	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.93815119
98	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.93332823
99	P300_18555785_Chip-Seq_ESCs_Mouse	0.93328602
100	ETV1_20927104_ChIP-Seq_GIST48_Human	0.92230360

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001529_abnormal_vocalization	3.96360211
2	MP0002736_abnormal_nociception_after	3.80942697
3	MP0000569_abnormal_digit_pigmentation	3.75680140
4	MP0002277_abnormal_respiratory_mucosa	3.61849314
5	MP0003195_calcinosis	3.40505587
6	MP0005645_abnormal_hypothalamus_physiol	3.16430424
7	MP0002735_abnormal_chemical_nociception	3.15489141
8	MP0001968_abnormal_touch/_nociception	3.14064591
9	MP0008877_abnormal_DNA_methylation	3.00064670
10	MP0002139_abnormal_hepatobiliary_system	2.96671587
11	MP0003646_muscle_fatigue	2.89713873
12	MP0003787_abnormal_imprinting	2.66061813
13	MP0008995_early_reproductive_senescence	2.02410618
14	MP0009780_abnormal_chondrocyte_physiolo	1.99423373
15	MP0002734_abnormal_mechanical_nocicepti	1.95647324
16	MP0008872_abnormal_physiological_respon	1.87070820
17	MP0002876_abnormal_thyroid_physiology	1.85903009
18	MP0005253_abnormal_eye_physiology	1.81813639
19	MP0005394_taste/olfaction_phenotype	1.77650772
20	MP0005499_abnormal_olfactory_system	1.77650772
21	MP0001764_abnormal_homeostasis	1.73075230
22	MP0009046_muscle_twitch	1.73031701
23	MP0008789_abnormal_olfactory_epithelium	1.72762891
24	MP0002272_abnormal_nervous_system	1.69602390
25	MP0001970_abnormal_pain_threshold	1.62415979
26	MP0006276_abnormal_autonomic_nervous	1.57573387
27	MP0002102_abnormal_ear_morphology	1.57107908
28	MP0004142_abnormal_muscle_tone	1.55056627
29	MP0003011_delayed_dark_adaptation	1.54961790
30	MP0001984_abnormal_olfaction	1.54423138
31	MP0005551_abnormal_eye_electrophysiolog	1.54288700
32	MP0009745_abnormal_behavioral_response	1.50872423
33	MP0005410_abnormal_fertilization	1.50376451
34	MP0005085_abnormal_gallbladder_physiolo	1.49438286
35	MP0001542_abnormal_bone_strength	1.49292236
36	MP0002933_joint_inflammation	1.46924807
37	MP0006054_spinal_hemorrhage	1.41527444
38	MP0000372_irregular_coat_pigmentation	1.41287300
39	MP0004147_increased_porphyrin_level	1.32772646
40	MP0005646_abnormal_pituitary_gland	1.29700372
41	MP0002638_abnormal_pupillary_reflex	1.25973553
42	MP0002163_abnormal_gland_morphology	1.23372315
43	MP0001501_abnormal_sleep_pattern	1.23240172
44	MP0005386_behavior/neurological_phenoty	1.23117325
45	MP0004924_abnormal_behavior	1.23117325
46	MP0003045_fibrosis	1.22556320
47	MP0002234_abnormal_pharynx_morphology	1.22155586
48	MP0006072_abnormal_retinal_apoptosis	1.22130493
49	MP0008057_abnormal_DNA_replication	1.19852893
50	MP0003880_abnormal_central_pattern	1.17258232
51	MP0004145_abnormal_muscle_electrophysio	1.16074085
52	MP0003122_maternal_imprinting	1.09117791
53	MP0003633_abnormal_nervous_system	1.07646469
54	MP0002572_abnormal_emotion/affect_behav	1.06910723
55	MP0005084_abnormal_gallbladder_morpholo	1.05956629
56	MP0001502_abnormal_circadian_rhythm	1.03110985
57	MP0000778_abnormal_nervous_system	1.01748524
58	MP0005535_abnormal_body_temperature	0.99959614
59	MP0003631_nervous_system_phenotype	0.98434284
60	MP0002067_abnormal_sensory_capabilities	0.95497539
61	MP0003186_abnormal_redox_activity	0.95358617
62	MP0002751_abnormal_autonomic_nervous	0.95038725
63	MP0004885_abnormal_endolymph	0.94151955
64	MP0002168_other_aberrant_phenotype	0.93872020
65	MP0001440_abnormal_grooming_behavior	0.93170125
66	MP0000230_abnormal_systemic_arterial	0.90076136
67	MP0001666_abnormal_nutrient_absorption	0.89412308
68	MP0003121_genomic_imprinting	0.89305888
69	MP0009697_abnormal_copulation	0.87372056
70	MP0002090_abnormal_vision	0.87226271
71	MP0001486_abnormal_startle_reflex	0.85674422
72	MP0009764_decreased_sensitivity_to	0.84173061
73	MP0002938_white_spotting	0.83768922
74	MP0003698_abnormal_male_reproductive	0.81500724
75	MP0004043_abnormal_pH_regulation	0.80865568
76	MP0003221_abnormal_cardiomyocyte_apopto	0.80420165
77	MP0002233_abnormal_nose_morphology	0.80220890
78	MP0005389_reproductive_system_phenotype	0.79749693
79	MP0004883_abnormal_blood_vessel	0.79693855
80	MP0002557_abnormal_social/conspecific_i	0.79668962
81	MP0008875_abnormal_xenobiotic_pharmacok	0.79108829
82	MP0002064_seizures	0.78800169
83	MP0002160_abnormal_reproductive_system	0.78764596
84	MP0002733_abnormal_thermal_nociception	0.75865350
85	MP0004133_heterotaxia	0.75772117
86	MP0003786_premature_aging	0.75184162
87	MP0005195_abnormal_posterior_eye	0.73961319
88	MP0005376_homeostasis/metabolism_phenot	0.73790456
89	MP0004270_analgesia	0.71412461
90	MP0003632_abnormal_nervous_system	0.71044752
91	MP0003635_abnormal_synaptic_transmissio	0.71040489
92	MP0008058_abnormal_DNA_repair	0.70790749
93	MP0001929_abnormal_gametogenesis	0.70617082
94	MP0010329_abnormal_lipoprotein_level	0.70498665
95	MP0003315_abnormal_perineum_morphology	0.70207574
96	MP0008775_abnormal_heart_ventricle	0.67236437
97	MP0008961_abnormal_basal_metabolism	0.66973313
98	MP0005395_other_phenotype	0.66322713
99	MP0005379_endocrine/exocrine_gland_phen	0.65736257
100	MP0004484_altered_response_of	0.64718479

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Thyroiditis (HP:0100646)	4.22456636
2	Increased hepatocellular lipid droplets (HP:0006565)	4.17858164
3	Lipid accumulation in hepatocytes (HP:0006561)	4.00704583
4	Medial flaring of the eyebrow (HP:0010747)	3.75559718
5	Hypoproteinemia (HP:0003075)	3.61117827
6	Gait imbalance (HP:0002141)	3.34580176
7	Thyroid-stimulating hormone excess (HP:0002925)	3.31436985
8	Severe combined immunodeficiency (HP:0004430)	3.26694380
9	Pancreatic cysts (HP:0001737)	3.11314849
10	Absent speech (HP:0001344)	3.04143231
11	Congenital stationary night blindness (HP:0007642)	2.98899009
12	Fibular aplasia (HP:0002990)	2.88371951
13	Congenital primary aphakia (HP:0007707)	2.88243949
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.85726739
15	Mitochondrial inheritance (HP:0001427)	2.82126667
16	Type II lissencephaly (HP:0007260)	2.78749841
17	Renal Fanconi syndrome (HP:0001994)	2.72162248
18	Polyphagia (HP:0002591)	2.71820756
19	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.66061616
20	Increased CSF lactate (HP:0002490)	2.58449085
21	Abnormal number of erythroid precursors (HP:0012131)	2.58340874
22	Abnormality of midbrain morphology (HP:0002418)	2.49480533
23	Molar tooth sign on MRI (HP:0002419)	2.49480533
24	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.49122243
25	Abnormality of renal resorption (HP:0011038)	2.47338986
26	Exertional dyspnea (HP:0002875)	2.46416671
27	Focal motor seizures (HP:0011153)	2.44918038
28	Abnormality of B cell number (HP:0010975)	2.44473088
29	Nephrogenic diabetes insipidus (HP:0009806)	2.42743651
30	Cerebellar dysplasia (HP:0007033)	2.42513569
31	Chronic sinusitis (HP:0011109)	2.41293605
32	B lymphocytopenia (HP:0010976)	2.40208358
33	Congenital, generalized hypertrichosis (HP:0004540)	2.36625044
34	Respiratory difficulties (HP:0002880)	2.36431204
35	Methylmalonic acidemia (HP:0002912)	2.34837170
36	Hypothermia (HP:0002045)	2.33791029
37	Pancreatic fibrosis (HP:0100732)	2.33244274
38	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.32801297
39	Increased intramyocellular lipid droplets (HP:0012240)	2.31927627
40	Constricted visual fields (HP:0001133)	2.30695904
41	Abnormality of the renal medulla (HP:0100957)	2.30612065
42	Combined immunodeficiency (HP:0005387)	2.29261074
43	Abnormality of the renal cortex (HP:0011035)	2.27863429
44	Abolished electroretinogram (ERG) (HP:0000550)	2.27773846
45	Hepatocellular necrosis (HP:0001404)	2.27318647
46	True hermaphroditism (HP:0010459)	2.24847275
47	Nephronophthisis (HP:0000090)	2.23593707
48	Dyschromatopsia (HP:0007641)	2.23589100
49	Abnormal respiratory motile cilium morphology (HP:0005938)	2.22982503
50	Abnormal respiratory epithelium morphology (HP:0012253)	2.22982503
51	Gaze-evoked nystagmus (HP:0000640)	2.22647586
52	Abnormality of cells of the erythroid lineage (HP:0012130)	2.19361375
53	Testicular atrophy (HP:0000029)	2.15820129
54	Broad-based gait (HP:0002136)	2.15027556
55	Intestinal atresia (HP:0011100)	2.14112797
56	Short foot (HP:0001773)	2.12644459
57	Abnormal ciliary motility (HP:0012262)	2.11931303
58	Abnormal hair whorl (HP:0010721)	2.11621808
59	Renal cortical cysts (HP:0000803)	2.11432012
60	Vaginal atresia (HP:0000148)	2.10019809
61	Hepatic necrosis (HP:0002605)	2.08488332
62	Attenuation of retinal blood vessels (HP:0007843)	2.08159027
63	Hypoplasia of the thymus (HP:0000778)	2.05939792
64	Abnormality of the pons (HP:0007361)	2.05733475
65	Genital tract atresia (HP:0001827)	2.05504766
66	3-Methylglutaconic aciduria (HP:0003535)	2.05184483
67	Bony spicule pigmentary retinopathy (HP:0007737)	2.05107706
68	Abnormal rod and cone electroretinograms (HP:0008323)	2.03558324
69	Abnormality of binocular vision (HP:0011514)	2.02163217
70	Diplopia (HP:0000651)	2.02163217
71	Hypoplasia of the pons (HP:0012110)	2.01915299
72	Facial diplegia (HP:0001349)	2.01521762
73	Facial cleft (HP:0002006)	2.00947359
74	Increased serum lactate (HP:0002151)	1.99460651
75	Hypoplasia of the uterus (HP:0000013)	1.95852736
76	Postaxial foot polydactyly (HP:0001830)	1.91371445
77	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.87899438
78	Short tibia (HP:0005736)	1.87496986
79	Postaxial hand polydactyly (HP:0001162)	1.86987346
80	Long clavicles (HP:0000890)	1.83928899
81	Increased muscle lipid content (HP:0009058)	1.83813480
82	Poikilocytosis (HP:0004447)	1.83685662
83	Acute necrotizing encephalopathy (HP:0006965)	1.82817937
84	Decreased central vision (HP:0007663)	1.82531350
85	Progressive inability to walk (HP:0002505)	1.81461367
86	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.80619413
87	Progressive macrocephaly (HP:0004481)	1.79400218
88	Hyperkalemia (HP:0002153)	1.77639553
89	Dyskinesia (HP:0100660)	1.76933974
90	Abnormality of eosinophils (HP:0001879)	1.76907863
91	Abnormality of the pubic bones (HP:0003172)	1.75942318
92	Abnormality of the alveolar ridges (HP:0006477)	1.75155108
93	Inability to walk (HP:0002540)	1.75094213
94	Absent/shortened dynein arms (HP:0200106)	1.74925197
95	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.74925197
96	Febrile seizures (HP:0002373)	1.74699731
97	Rimmed vacuoles (HP:0003805)	1.74498589
98	Abnormal respiratory motile cilium physiology (HP:0012261)	1.72932984
99	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.72228059
100	Hemiparesis (HP:0001269)	1.72027472

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.04769711
2	MAPK13	3.95339973
3	BRSK2	2.84314804
4	BMPR1B	2.60874363
5	BMPR2	2.59323806
6	WNK4	2.44866959
7	BCR	2.28449925
8	TNIK	2.08861383
9	DAPK2	2.08587649
10	WNK3	1.99516688
11	CASK	1.95267242
12	ZAK	1.90910251
13	MAP3K4	1.87891498
14	MKNK2	1.85057976
15	NTRK3	1.74148688
16	PNCK	1.60816102
17	MARK1	1.59832781
18	FLT3	1.58659420
19	PLK2	1.57917274
20	BCKDK	1.54519697
21	ACVR1B	1.50838642
22	CAMKK2	1.40149379
23	MKNK1	1.38319603
24	GRK1	1.37677321
25	MAP4K2	1.36893274
26	EIF2AK3	1.32950282
27	GRK6	1.24864592
28	KIT	1.24621114
29	ERBB3	1.21346433
30	DYRK3	1.20647504
31	STK39	1.18799833
32	TEC	1.15635412
33	WNK1	1.12866324
34	NUAK1	1.12688826
35	ADRBK2	1.11209561
36	MAP3K12	1.10890711
37	PRKCE	1.09825257
38	TRPM7	1.07978133
39	TAOK3	1.07428678
40	PHKG2	1.01960134
41	PHKG1	1.01960134
42	SGK2	0.96193961
43	PRKCG	0.92636761
44	OXSR1	0.91775095
45	STK16	0.91172344
46	DYRK2	0.90765753
47	PAK3	0.89921117
48	ADRBK1	0.88453046
49	MAP2K7	0.88045574
50	CDK19	0.85773660
51	WEE1	0.85511670
52	CSF1R	0.76814169
53	CLK1	0.76512697
54	INSRR	0.75164414
55	TRIM28	0.75124297
56	CSNK1G2	0.69860784
57	PTK2B	0.69697728
58	SCYL2	0.67865217
59	CSNK1A1L	0.67419971
60	PKN1	0.66712671
61	EPHA4	0.65566042
62	SYK	0.65090849
63	STK11	0.63860200
64	CSNK1G1	0.62059137
65	NEK9	0.61331324
66	SGK494	0.60539871
67	SGK223	0.60539871
68	MAP3K2	0.58763642
69	TGFBR1	0.56128884
70	CSNK1G3	0.55616295
71	PINK1	0.54707777
72	PLK4	0.52908718
73	MST4	0.52827655
74	BRD4	0.52643419
75	PRKG1	0.52544461
76	PLK3	0.52238252
77	SGK1	0.51080532
78	MAP2K4	0.49779626
79	BRSK1	0.46772175
80	RPS6KA5	0.45939569
81	CAMK1	0.45635141
82	CAMK2A	0.45514068
83	VRK1	0.44947696
84	ERBB2	0.43877956
85	NLK	0.42243788
86	RPS6KA4	0.41909941
87	PIK3CG	0.41595326
88	CSNK1A1	0.41121525
89	AKT3	0.39239672
90	PRKCQ	0.37819045
91	CAMK1G	0.36934303
92	OBSCN	0.35300340
93	MINK1	0.34609660
94	GSK3A	0.34490134
95	CSNK1D	0.32508282
96	DYRK1A	0.31737124
97	PIK3CA	0.31621501
98	PRKACA	0.31584344
99	CAMK2D	0.31328089
100	BTK	0.30504626

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.53692595
2	Allograft rejection_Homo sapiens_hsa05330	3.75351660
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.69475774
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.63484486
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.63186567
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.45104371
7	Nitrogen metabolism_Homo sapiens_hsa00910	3.26480782
8	Non-homologous end-joining_Homo sapiens_hsa03450	3.01072942
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.26624797
10	Protein export_Homo sapiens_hsa03060	2.04149282
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.84454700
12	ABC transporters_Homo sapiens_hsa02010	1.84374230
13	Phototransduction_Homo sapiens_hsa04744	1.73086918
14	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.66690908
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.62532923
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.61025780
17	Parkinsons disease_Homo sapiens_hsa05012	1.60242235
18	Viral myocarditis_Homo sapiens_hsa05416	1.59890032
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.58305780
20	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.56764355
21	Butanoate metabolism_Homo sapiens_hsa00650	1.55597742
22	Huntingtons disease_Homo sapiens_hsa05016	1.55305331
23	Circadian rhythm_Homo sapiens_hsa04710	1.49162832
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.46484516
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.45018689
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.42062864
27	Antigen processing and presentation_Homo sapiens_hsa04612	1.37039687
28	Regulation of autophagy_Homo sapiens_hsa04140	1.32073595
29	Taste transduction_Homo sapiens_hsa04742	1.31976873
30	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.27043904
31	Nicotine addiction_Homo sapiens_hsa05033	1.24784396
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.24731152
33	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.23411703
34	Olfactory transduction_Homo sapiens_hsa04740	1.22266846
35	Homologous recombination_Homo sapiens_hsa03440	1.14975525
36	Alzheimers disease_Homo sapiens_hsa05010	1.14219316
37	RNA degradation_Homo sapiens_hsa03018	1.11268760
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.07550826
39	Fat digestion and absorption_Homo sapiens_hsa04975	1.06607291
40	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.02724608
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.02391394
42	Propanoate metabolism_Homo sapiens_hsa00640	1.00074284
43	Cardiac muscle contraction_Homo sapiens_hsa04260	0.98599003
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93275158
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.92274251
46	Leishmaniasis_Homo sapiens_hsa05140	0.90346110
47	Peroxisome_Homo sapiens_hsa04146	0.86408796
48	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.83374229
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74770609
50	Ribosome_Homo sapiens_hsa03010	0.73998304
51	Caffeine metabolism_Homo sapiens_hsa00232	0.73921741
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73529499
53	RNA polymerase_Homo sapiens_hsa03020	0.71322453
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.70307341
55	Circadian entrainment_Homo sapiens_hsa04713	0.68404636
56	Glutamatergic synapse_Homo sapiens_hsa04724	0.64664170
57	Morphine addiction_Homo sapiens_hsa05032	0.64283536
58	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.61413787
59	Basal transcription factors_Homo sapiens_hsa03022	0.61078305
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.60803490
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.60470054
62	GABAergic synapse_Homo sapiens_hsa04727	0.54068357
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52463979
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52260299
65	Calcium signaling pathway_Homo sapiens_hsa04020	0.51347213
66	Primary immunodeficiency_Homo sapiens_hsa05340	0.48652643
67	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.45348032
68	Long-term depression_Homo sapiens_hsa04730	0.43256595
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42966988
70	Mineral absorption_Homo sapiens_hsa04978	0.42512695
71	Tyrosine metabolism_Homo sapiens_hsa00350	0.41279584
72	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.40164085
73	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.37576452
74	Steroid biosynthesis_Homo sapiens_hsa00100	0.37249472
75	RNA transport_Homo sapiens_hsa03013	0.36644285
76	Retinol metabolism_Homo sapiens_hsa00830	0.36003594
77	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.35688844
78	Phagosome_Homo sapiens_hsa04145	0.35184403
79	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.35058567
80	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33919922
81	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.32513337
82	Insulin secretion_Homo sapiens_hsa04911	0.32406961
83	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.31924352
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.31258421
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.30995173
86	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.30853300
87	Tuberculosis_Homo sapiens_hsa05152	0.29760737
88	Fanconi anemia pathway_Homo sapiens_hsa03460	0.27620329
89	p53 signaling pathway_Homo sapiens_hsa04115	0.26209764
90	Salivary secretion_Homo sapiens_hsa04970	0.25935903
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.24985030
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.24963424
93	Toxoplasmosis_Homo sapiens_hsa05145	0.24471196
94	Metabolic pathways_Homo sapiens_hsa01100	0.22869395
95	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.22746716
96	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.19394183
97	Collecting duct acid secretion_Homo sapiens_hsa04966	0.18289331
98	Fatty acid degradation_Homo sapiens_hsa00071	0.18199990
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.17980661
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.15480071

TAF9BP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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