TAGAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.78962059
2regulation of gamma-delta T cell differentiation (GO:0045586)6.77239110
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.54598551
4negative regulation of cell killing (GO:0031342)6.54598551
5regulation of gamma-delta T cell activation (GO:0046643)6.24624594
6regulation of interleukin-12 biosynthetic process (GO:0045075)5.99715201
7regulation of isotype switching to IgG isotypes (GO:0048302)5.74976679
8positive thymic T cell selection (GO:0045059)5.71525300
9negative T cell selection (GO:0043383)5.59027718
10negative thymic T cell selection (GO:0045060)5.50343797
11positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.38789856
12regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.12603481
13interferon-gamma production (GO:0032609)5.01469172
14positive T cell selection (GO:0043368)4.99836838
15positive regulation of isotype switching (GO:0045830)4.85194740
16regulation of B cell receptor signaling pathway (GO:0050855)4.75384120
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.72602248
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.72602248
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.71665048
20positive regulation of immunoglobulin mediated immune response (GO:0002891)4.52217896
21positive regulation of B cell mediated immunity (GO:0002714)4.52217896
22thymic T cell selection (GO:0045061)4.51366246
23antigen processing and presentation of endogenous antigen (GO:0019883)4.46199238
24positive regulation of humoral immune response (GO:0002922)4.44400108
25response to interleukin-15 (GO:0070672)4.41800189
26neutrophil activation involved in immune response (GO:0002283)4.38852268
27T cell migration (GO:0072678)4.38108461
28detection of other organism (GO:0098543)4.36770923
29cellular extravasation (GO:0045123)4.29494803
30positive regulation of DNA recombination (GO:0045911)4.26074145
31NIK/NF-kappaB signaling (GO:0038061)4.25849948
32regulation of alpha-beta T cell proliferation (GO:0046640)4.21868054
33T cell selection (GO:0045058)4.21010572
34macrophage activation involved in immune response (GO:0002281)4.20284636
35detection of bacterium (GO:0016045)4.14749152
36leukocyte aggregation (GO:0070486)4.11963946
37cellular response to interleukin-15 (GO:0071350)4.11437449
38myeloid dendritic cell differentiation (GO:0043011)4.05385540
39negative regulation of interleukin-12 production (GO:0032695)4.02872795
40myeloid dendritic cell activation (GO:0001773)4.00673896
41positive regulation of alpha-beta T cell proliferation (GO:0046641)3.99540103
42regulation of interleukin-2 biosynthetic process (GO:0045076)3.99429073
43regulation of T cell tolerance induction (GO:0002664)3.99208873
44tolerance induction (GO:0002507)3.96211230
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.94933487
46negative regulation of T cell mediated immunity (GO:0002710)3.91391816
47endothelial cell chemotaxis (GO:0035767)3.90521912
48response to peptidoglycan (GO:0032494)3.88036414
49B cell receptor signaling pathway (GO:0050853)3.81783623
50positive regulation of interleukin-2 production (GO:0032743)3.78040486
51detection of external biotic stimulus (GO:0098581)3.73885462
52neutrophil activation (GO:0042119)3.73207609
53immunoglobulin mediated immune response (GO:0016064)3.72273346
54negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.71249409
55negative regulation of leukocyte mediated immunity (GO:0002704)3.70627425
56activated T cell proliferation (GO:0050798)3.70302132
57regulation of immunoglobulin mediated immune response (GO:0002889)3.67650685
58detection of molecule of bacterial origin (GO:0032490)3.67288129
59regulation of isotype switching (GO:0045191)3.64019992
60regulation of regulatory T cell differentiation (GO:0045589)3.63228631
61regulation of B cell mediated immunity (GO:0002712)3.62615007
62regulation of interferon-beta biosynthetic process (GO:0045357)3.62066449
63T cell receptor signaling pathway (GO:0050852)3.55436479
64regulation of immunoglobulin secretion (GO:0051023)3.54645764
65respiratory burst (GO:0045730)3.54518107
66positive regulation of natural killer cell mediated immunity (GO:0002717)3.54077635
67positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.54077635
68positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.52028864
69regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.50724322
70regulation of natural killer cell mediated immunity (GO:0002715)3.50724322
71positive regulation of immunoglobulin production (GO:0002639)3.48653130
72positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.44657843
73microglial cell activation (GO:0001774)3.44169959
74regulation of B cell differentiation (GO:0045577)3.43137423
75response to host immune response (GO:0052572)3.41995987
76response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.41995987
77granulocyte activation (GO:0036230)3.40031024
78regulation of chronic inflammatory response (GO:0002676)3.40026716
79myeloid cell activation involved in immune response (GO:0002275)3.38390017
80positive regulation of T cell cytokine production (GO:0002726)3.35127359
81detection of biotic stimulus (GO:0009595)3.34535906
82CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.32649460
83antigen processing and presentation via MHC class Ib (GO:0002475)3.32528979
84response to muramyl dipeptide (GO:0032495)3.32288110
85positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.30266985
86positive regulation of tolerance induction (GO:0002645)3.29486932
87regulation of immunoglobulin production (GO:0002637)3.29038323
88regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.28742944
89T cell costimulation (GO:0031295)3.28524804
90negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.28342014
91negative regulation of T-helper cell differentiation (GO:0045623)3.28342014
92neutrophil mediated immunity (GO:0002446)3.27119845
93JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.26038748
94positive regulation of B cell differentiation (GO:0045579)3.23139412
95regulation of leukocyte mediated cytotoxicity (GO:0001910)3.22065623
96lymphocyte costimulation (GO:0031294)3.21818545
97antigen receptor-mediated signaling pathway (GO:0050851)3.20800846
98positive regulation of lymphocyte mediated immunity (GO:0002708)3.20071541
99response to type I interferon (GO:0034340)3.18771382
100macrophage activation (GO:0042116)3.18144680
101type I interferon signaling pathway (GO:0060337)3.16070496
102cellular response to type I interferon (GO:0071357)3.16070496
103response to host (GO:0075136)3.15373984
104response to host defenses (GO:0052200)3.15373984
105response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.15373984
106positive regulation of cell killing (GO:0031343)3.14886711
107production of molecular mediator involved in inflammatory response (GO:0002532)3.14731522
108interferon-gamma-mediated signaling pathway (GO:0060333)3.12905571
109natural killer cell activation (GO:0030101)3.12474303
110regulation of cell killing (GO:0031341)3.11222168
111defense response to protozoan (GO:0042832)3.10755389
112germinal center formation (GO:0002467)3.10458821
113regulation of response to interferon-gamma (GO:0060330)3.08841355
114negative regulation of lymphocyte mediated immunity (GO:0002707)3.08593424
115positive regulation of granulocyte differentiation (GO:0030854)3.07474524
116negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.06373180
117T cell proliferation (GO:0042098)3.05978979
118positive regulation of T cell mediated cytotoxicity (GO:0001916)3.05443798
119leukocyte cell-cell adhesion (GO:0007159)3.04640916
120positive regulation of interleukin-12 production (GO:0032735)3.04446132
121regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.03814282
122regulation of interleukin-2 production (GO:0032663)3.03676057
123regulation of mast cell degranulation (GO:0043304)3.01693367
124leukocyte degranulation (GO:0043299)3.01316520
125mast cell activation (GO:0045576)3.01024100
126regulation of tolerance induction (GO:0002643)3.00402830
127B cell mediated immunity (GO:0019724)3.00017954
128myeloid leukocyte mediated immunity (GO:0002444)2.97038132
129negative regulation of erythrocyte differentiation (GO:0045647)2.95703941
130tyrosine phosphorylation of STAT protein (GO:0007260)2.94744603
131regulation of T cell mediated cytotoxicity (GO:0001914)2.94681238
132leukocyte migration involved in inflammatory response (GO:0002523)2.94065285
133lymphocyte migration (GO:0072676)2.93797986
134response to protozoan (GO:0001562)2.93617237
135regulation of T cell chemotaxis (GO:0010819)2.93581322
136positive regulation of T cell chemotaxis (GO:0010820)2.93581322
137regulation of dendritic cell antigen processing and presentation (GO:0002604)2.92182026
138negative regulation of innate immune response (GO:0045824)2.91183663
139modulation by symbiont of host defense response (GO:0052031)2.90618795
140modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.90618795
141modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.90618795
142positive regulation by organism of defense response of other organism involved in symbiotic interact2.90618795
143modulation by symbiont of host immune response (GO:0052553)2.90618795
144positive regulation by symbiont of host defense response (GO:0052509)2.90618795
145negative regulation of adaptive immune response (GO:0002820)2.89302712

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.67925538
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.83463425
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.60974451
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.08275456
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.99759279
6* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.98054818
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.96980466
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.84087120
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.50963057
10NOTCH1_21737748_ChIP-Seq_TLL_Human3.38943081
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.38889475
12* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.27507482
13* RUNX_20019798_ChIP-Seq_JUKART_Human3.25217332
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.20611875
15MYC_22102868_ChIP-Seq_BL_Human3.16428985
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.16412401
17* IRF8_27001747_Chip-Seq_BMDM_Mouse3.08521703
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.98107832
19* MYB_26560356_Chip-Seq_TH2_Human2.89331848
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.83275252
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70345517
22MAF_26560356_Chip-Seq_TH1_Human2.58676488
23MYB_26560356_Chip-Seq_TH1_Human2.49984111
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.44240809
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.29707983
26UTX_26944678_Chip-Seq_JUKART_Human2.13126712
27E2F7_22180533_ChIP-Seq_HELA_Human2.06865660
28VDR_21846776_ChIP-Seq_THP-1_Human2.05204725
29* SPI1_23547873_ChIP-Seq_NB4_Human1.94661808
30SCL_19346495_ChIP-Seq_HPC-7_Human1.93340023
31* TCF7_22412390_ChIP-Seq_EML_Mouse1.93145966
32* RUNX1_22412390_ChIP-Seq_EML_Mouse1.91860891
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89102211
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88483269
35VDR_24763502_ChIP-Seq_THP-1_Human1.88366449
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83987909
37* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83251270
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.82834486
39GATA3_27048872_Chip-Seq_THYMUS_Human1.82080509
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81643760
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75079307
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70362847
43MAF_26560356_Chip-Seq_TH2_Human1.65204057
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59500954
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52497321
46PU_27001747_Chip-Seq_BMDM_Mouse1.49253934
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49075926
48SPI1_23127762_ChIP-Seq_K562_Human1.48507566
49* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47415451
50KDM2B_26808549_Chip-Seq_DND41_Human1.46220897
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37406363
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37137640
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33394010
54GATA3_26560356_Chip-Seq_TH2_Human1.26789224
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26598560
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24948333
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23769971
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22394273
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17601024
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16283106
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13894167
62VDR_24787735_ChIP-Seq_THP-1_Human1.12434435
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11880993
64* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10693438
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.09482036
66* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07717478
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07245897
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05705764
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04487379
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02829604
71* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01620809
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99251278
73KDM2B_26808549_Chip-Seq_JURKAT_Human0.98698611
74GATA2_21666600_ChIP-Seq_HMVEC_Human0.97714774
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97560438
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96671586
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93533587
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93250486
79SMAD_19615063_ChIP-ChIP_OVARY_Human0.92279333
80* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91807720
81EGR1_19032775_ChIP-ChIP_M12_Human0.90256055
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90250770
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89656034
84STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87996996
85* BCL6_27268052_Chip-Seq_Bcells_Human0.87677716
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86239853
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84967287
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84902397
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84203204
90GATA1_22025678_ChIP-Seq_K562_Human0.84151402
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82344291
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80250437
93* BCOR_27268052_Chip-Seq_Bcells_Human0.79825390
94VDR_23849224_ChIP-Seq_CD4+_Human0.79509630
95NCOR1_26117541_ChIP-Seq_K562_Human0.78931228
96IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76882311
97CIITA_25753668_ChIP-Seq_RAJI_Human0.73480421
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.70990071
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.69383985
100GATA1_19941827_ChIP-Seq_MEL_Mouse0.69319196
101RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67764280
102GATA2_19941826_ChIP-Seq_K562_Human0.65633614
103* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64588677
104ELK1_19687146_ChIP-ChIP_HELA_Human0.63557350
105* SMRT_27268052_Chip-Seq_Bcells_Human0.62164814
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61975187
107GATA1_19941826_ChIP-Seq_K562_Human0.58743865
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.57508985
109ETS1_22383799_ChIP-Seq_G1ME_Mouse0.57020734
110FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.56298922
111FOXM1_23109430_ChIP-Seq_U2OS_Human0.55833629

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.15352253
2MP0001835_abnormal_antigen_presentation4.09677588
3MP0005671_abnormal_response_to4.02358951
4MP0006082_CNS_inflammation3.62437237
5MP0000685_abnormal_immune_system3.54244404
6MP0003436_decreased_susceptibility_to3.49294827
7MP0005000_abnormal_immune_tolerance3.22414031
8MP0001800_abnormal_humoral_immune3.18159217
9MP0009785_altered_susceptibility_to3.09485944
10MP0001790_abnormal_immune_system2.98350884
11MP0005387_immune_system_phenotype2.98350884
12MP0002723_abnormal_immune_serum2.85298163
13MP0002452_abnormal_antigen_presenting2.76255873
14MP0002405_respiratory_system_inflammati2.74914513
15MP0003303_peritoneal_inflammation2.71663967
16MP0002420_abnormal_adaptive_immunity2.65384051
17MP0002148_abnormal_hypersensitivity_rea2.64783553
18MP0001819_abnormal_immune_cell2.64107293
19MP0004510_myositis2.61935243
20MP0005025_abnormal_response_to2.57121668
21MP0003300_gastrointestinal_ulcer2.45960052
22MP0002419_abnormal_innate_immunity2.45148986
23MP0003724_increased_susceptibility_to2.40066092
24MP0009333_abnormal_splenocyte_physiolog2.39888083
25MP0002398_abnormal_bone_marrow2.39696129
26MP0001853_heart_inflammation2.32144827
27MP0002166_altered_tumor_susceptibility2.26527042
28MP0000716_abnormal_immune_system2.18467973
29MP0010155_abnormal_intestine_physiology2.03597027
30MP0002006_tumorigenesis2.02716558
31MP0000689_abnormal_spleen_morphology1.99406700
32MP0004947_skin_inflammation1.98591854
33MP0001873_stomach_inflammation1.93197066
34MP0005464_abnormal_platelet_physiology1.92538470
35MP0002722_abnormal_immune_system1.91316620
36MP0000703_abnormal_thymus_morphology1.90570942
37MP0003866_abnormal_defecation1.87346681
38MP0002396_abnormal_hematopoietic_system1.87042474
39MP0001845_abnormal_inflammatory_respons1.83705138
40MP0002429_abnormal_blood_cell1.77126187
41MP0008260_abnormal_autophagy1.73581269
42MP0001533_abnormal_skeleton_physiology1.72079045
43MP0004808_abnormal_hematopoietic_stem1.68716882
44MP0000465_gastrointestinal_hemorrhage1.60116034
45MP0002933_joint_inflammation1.46319982
46MP0000858_altered_metastatic_potential1.42601802
47MP0002138_abnormal_hepatobiliary_system1.40926343
48MP0001851_eye_inflammation1.36674602
49MP0002998_abnormal_bone_remodeling1.33972458
50MP0008469_abnormal_protein_level1.32400539
51MP0005310_abnormal_salivary_gland1.31980167
52MP0005451_abnormal_body_composition1.29503585
53MP0003172_abnormal_lysosome_physiology1.24761868
54MP0003448_altered_tumor_morphology1.21503391
55MP0003045_fibrosis1.17124200
56MP0008057_abnormal_DNA_replication1.16213779
57MP0000604_amyloidosis1.07946042
58MP0002132_abnormal_respiratory_system1.05646936
59MP0005397_hematopoietic_system_phenotyp1.05031334
60MP0001545_abnormal_hematopoietic_system1.05031334
61MP0009278_abnormal_bone_marrow1.02724474
62MP0005166_decreased_susceptibility_to1.02606860
63MP0003191_abnormal_cellular_cholesterol1.00568871
64MP0005058_abnormal_lysosome_morphology0.99515615
65MP0009764_decreased_sensitivity_to0.98207122
66MP0005164_abnormal_response_to0.96349382
67MP0000490_abnormal_crypts_of0.92828471
68MP0003075_altered_response_to0.87798336
69MP0010307_abnormal_tumor_latency0.86916743
70MP0002019_abnormal_tumor_incidence0.82266762
71MP0003656_abnormal_erythrocyte_physiolo0.81035318
72MP0005390_skeleton_phenotype0.80037286
73MP0008004_abnormal_stomach_pH0.78557654
74MP0008961_abnormal_basal_metabolism0.78353634
75MP0008007_abnormal_cellular_replicative0.78317001
76MP0005423_abnormal_somatic_nervous0.76574220
77MP0003795_abnormal_bone_structure0.73195534
78MP0002277_abnormal_respiratory_mucosa0.72783896
79MP0010352_gastrointestinal_tract_polyps0.71893223
80MP0000015_abnormal_ear_pigmentation0.71657835
81MP0009763_increased_sensitivity_to0.70262344
82MP0005076_abnormal_cell_differentiation0.70199260
83MP0001986_abnormal_taste_sensitivity0.70192391
84MP0004130_abnormal_muscle_cell0.69790078
85MP0005023_abnormal_wound_healing0.67816805
86MP0000249_abnormal_blood_vessel0.66895543
87MP0000609_abnormal_liver_physiology0.64921626
88MP0003453_abnormal_keratinocyte_physiol0.62648319
89MP0002136_abnormal_kidney_physiology0.61125382
90MP0003221_abnormal_cardiomyocyte_apopto0.59452000
91MP0000343_altered_response_to0.58276029
92MP0002254_reproductive_system_inflammat0.57259514
93MP0005075_abnormal_melanosome_morpholog0.55550012
94MP0008874_decreased_physiological_sensi0.54752647
95MP0002009_preneoplasia0.53829229
96MP0003183_abnormal_peptide_metabolism0.53798709
97MP0009765_abnormal_xenobiotic_induced0.52150978
98MP0003077_abnormal_cell_cycle0.52128327
99MP0002928_abnormal_bile_duct0.52008785
100MP0004782_abnormal_surfactant_physiolog0.51518616
101MP0004484_altered_response_of0.50773745
102MP0000569_abnormal_digit_pigmentation0.50773597
103MP0008873_increased_physiological_sensi0.49575113
104MP0003690_abnormal_glial_cell0.48900024
105MP0009840_abnormal_foam_cell0.47995367
106MP0002693_abnormal_pancreas_physiology0.46563446
107MP0004883_abnormal_blood_vessel0.46463269
108MP0001663_abnormal_digestive_system0.46279628
109MP0005381_digestive/alimentary_phenotyp0.45846184
110MP0003828_pulmonary_edema0.45242411
111MP0004381_abnormal_hair_follicle0.44792848
112MP0003091_abnormal_cell_migration0.43936771
113MP0001881_abnormal_mammary_gland0.42988419
114MP0005376_homeostasis/metabolism_phenot0.40121771

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)7.05219393
2Eczematoid dermatitis (HP:0000976)5.70903329
3T lymphocytopenia (HP:0005403)5.61222700
4Elevated erythrocyte sedimentation rate (HP:0003565)5.51900918
5Abnormality of T cell number (HP:0011839)5.48719710
6Recurrent fungal infections (HP:0002841)4.44406495
7Recurrent abscess formation (HP:0002722)4.40487827
8Abnormality of T cells (HP:0002843)4.29180168
9Myositis (HP:0100614)4.09832896
10Severe combined immunodeficiency (HP:0004430)4.07935871
11Recurrent viral infections (HP:0004429)4.06476766
12Mediastinal lymphadenopathy (HP:0100721)4.04527141
13Chronic diarrhea (HP:0002028)3.99458201
14Nasal polyposis (HP:0100582)3.99099699
15Recurrent bacterial skin infections (HP:0005406)3.92234771
16Increased IgM level (HP:0003496)3.89307025
17Combined immunodeficiency (HP:0005387)3.79518289
18Retrobulbar optic neuritis (HP:0100654)3.68439379
19Optic neuritis (HP:0100653)3.68439379
20Recurrent bronchitis (HP:0002837)3.65355623
21Chronic otitis media (HP:0000389)3.49412903
22Panhypogammaglobulinemia (HP:0003139)3.48992504
23IgG deficiency (HP:0004315)3.48861093
24IgM deficiency (HP:0002850)3.48304904
25Systemic lupus erythematosus (HP:0002725)3.48152597
26Orchitis (HP:0100796)3.47796829
27Recurrent cutaneous fungal infections (HP:0011370)3.46609560
28Chronic mucocutaneous candidiasis (HP:0002728)3.46609560
29Abnormality of the nasal mucosa (HP:0000433)3.33132420
30Vasculitis (HP:0002633)3.29997474
31Gastrointestinal infarctions (HP:0005244)3.23040944
32Leukocytosis (HP:0001974)3.21532147
33Pulmonary infiltrates (HP:0002113)3.19871689
34Autoimmune thrombocytopenia (HP:0001973)3.18914988
35Arterial thrombosis (HP:0004420)3.17820444
36IgA deficiency (HP:0002720)3.16388336
37Abnormality of eosinophils (HP:0001879)3.15603526
38Pustule (HP:0200039)3.14923319
39Abnormal delayed hypersensitivity skin test (HP:0002963)3.11085060
40Recurrent skin infections (HP:0001581)3.10298362
41Abnormality of T cell physiology (HP:0011840)3.08510747
42Urticaria (HP:0001025)3.06428727
43Prolonged bleeding time (HP:0003010)3.06373338
44Eosinophilia (HP:0001880)2.96691619
45Thyroiditis (HP:0100646)2.94404081
46Thrombocytosis (HP:0001894)2.89462918
47Joint swelling (HP:0001386)2.81591297
48Meningitis (HP:0001287)2.80398001
49Chronic obstructive pulmonary disease (HP:0006510)2.79883265
50Obstructive lung disease (HP:0006536)2.79883265
51Hypochromic anemia (HP:0001931)2.79066479
52Lymphopenia (HP:0001888)2.77344427
53Episodic fever (HP:0001954)2.77208724
54Abnormality of the fingertips (HP:0001211)2.76420805
55Hypochromic microcytic anemia (HP:0004840)2.75861538
56Gingivitis (HP:0000230)2.74077663
57Recurrent gram-negative bacterial infections (HP:0005420)2.72934864
58Abnormality of cells of the lymphoid lineage (HP:0012140)2.71485884
59Increased density of long bones (HP:0006392)2.71315375
60Hemoptysis (HP:0002105)2.70294341
61Abnormality of B cell number (HP:0010975)2.69010141
62B lymphocytopenia (HP:0010976)2.69010141
63Inflammation of the large intestine (HP:0002037)2.66659300
64Anorexia (HP:0002039)2.64891522
65Spontaneous hematomas (HP:0007420)2.64656597
66Glomerulonephritis (HP:0000099)2.61728104
67Gangrene (HP:0100758)2.56359166
68Gastrointestinal inflammation (HP:0004386)2.52708215
69Keratoconjunctivitis sicca (HP:0001097)2.51085974
70Hypergammaglobulinemia (HP:0010702)2.50815793
71Granulocytopenia (HP:0001913)2.49982844
72Persistence of primary teeth (HP:0006335)2.44010493
73Abnormality of the pleura (HP:0002103)2.42856486
74Chest pain (HP:0100749)2.42433129
75Lymphoma (HP:0002665)2.42225116
76Colitis (HP:0002583)2.42085888
77Peritonitis (HP:0002586)2.39221520
78Arterial tortuosity (HP:0005116)2.38507929
79Periodontitis (HP:0000704)2.37271931
80Sepsis (HP:0100806)2.36915395
81Agammaglobulinemia (HP:0004432)2.35981772
82Abnormality of the prostate (HP:0008775)2.34841217
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.31989682
84Amaurosis fugax (HP:0100576)2.31614990
85Recurrent sinusitis (HP:0011108)2.31259775
86Keratoconjunctivitis (HP:0001096)2.30571848
87Verrucae (HP:0200043)2.29599665
88Papilloma (HP:0012740)2.29599665
89Epistaxis (HP:0000421)2.29461312
90Abnormality of macrophages (HP:0004311)2.29244377
91Increased IgE level (HP:0003212)2.24335401
92Glomerulopathy (HP:0100820)2.24110851
93Encephalitis (HP:0002383)2.23262473
94Aortic aneurysm (HP:0004942)2.21881931
95Microcytic anemia (HP:0001935)2.21136009
96Slow saccadic eye movements (HP:0000514)2.21098716
97Abnormality of glycolipid metabolism (HP:0010969)2.19332912
98Abnormality of liposaccharide metabolism (HP:0010968)2.19332912
99Abnormality of glycosphingolipid metabolism (HP:0004343)2.19332912
100Stomach cancer (HP:0012126)2.19057104
101Autoimmune hemolytic anemia (HP:0001890)2.18474352
102Viral hepatitis (HP:0006562)2.18015695
103Fatigue (HP:0012378)2.15998869
104Keratitis (HP:0000491)2.14636180
105Gastrointestinal stroma tumor (HP:0100723)2.12777252
106Acute hepatic failure (HP:0006554)2.12515224
107Petechiae (HP:0000967)2.10785648
108Cellulitis (HP:0100658)2.09589967
109Abnormality of the peritoneum (HP:0002585)2.09511096
110Hematochezia (HP:0002573)2.09131017
111Myocardial infarction (HP:0001658)2.08423880
112Spondylolisthesis (HP:0003302)2.06344522
113Amyloidosis (HP:0011034)2.04923162
114Gingival bleeding (HP:0000225)2.02958672
115Vascular tortuosity (HP:0004948)2.01494590
116Skin ulcer (HP:0200042)2.00940832
117Bronchitis (HP:0012387)1.99904728
118Pulmonary embolism (HP:0002204)1.99124277
119Basal ganglia calcification (HP:0002135)1.97880483
120Hepatosplenomegaly (HP:0001433)1.97491224
121Emphysema (HP:0002097)1.96855636
122Osteomyelitis (HP:0002754)1.96808046
123Skin rash (HP:0000988)1.96648191
124Abnormality of the endocardium (HP:0004306)1.95938190
125Interstitial pulmonary disease (HP:0006530)1.94355949
126Vertigo (HP:0002321)1.93335368
127Restrictive lung disease (HP:0002091)1.93151558
128Papilledema (HP:0001085)1.92322665
129Polyneuropathy (HP:0001271)1.90064861

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.55099836
2TXK5.25737248
3MAP3K143.46309687
4ITK3.17859747
5JAK33.08817569
6ZAP703.00521099
7TGFBR22.91557397
8TYK22.87411761
9IKBKE2.45803524
10STK102.41628758
11IKBKB2.31369109
12PRPF4B2.28927816
13TBK12.25873608
14TEC1.96649846
15CSK1.96064080
16TNK21.94294816
17JAK11.92221287
18IRAK41.89466394
19CHUK1.85423341
20FGFR41.84489474
21LCK1.63157156
22BTK1.58887146
23HCK1.56196675
24NLK1.53034204
25TSSK61.52004940
26PIM21.47588978
27BLK1.45372722
28FGFR31.41638299
29IRAK31.37523523
30MAP3K101.37395033
31SYK1.36712481
32PIM11.33851065
33MAP2K31.31991441
34GRK61.27887705
35MAP3K131.27215047
36RPS6KA41.24857869
37KIT1.23064520
38MAP3K11.22927971
39EEF2K1.20070492
40CSF1R1.19649137
41FGR1.19351088
42EPHB11.10999666
43RIPK41.08748709
44MARK31.07941974
45IRAK21.04497191
46MST41.04088330
47MAPK151.02772272
48JAK21.01901381
49CDK121.00304332
50GRK70.94498251
51LYN0.92914766
52CLK10.91082071
53KSR20.88051086
54YES10.85598437
55CAMKK20.85575319
56MATK0.83950807
57PIK3CG0.83100059
58MARK20.82696751
59RPS6KA50.81524043
60EPHA30.81489388
61MAP3K110.78397311
62TESK20.77875356
63PRKCQ0.75510472
64TAOK10.74320057
65PRKD20.73111173
66MAP3K30.72241857
67MELK0.71550719
68CAMKK10.71547752
69FES0.70349865
70SIK20.66943913
71NME20.65633788
72MAP3K60.65025223
73IRAK10.62686283
74MAPK70.59595467
75FYN0.59316824
76SIK30.58448469
77ERN10.57933115
78PRKCH0.57832943
79NEK90.56204532
80MAP3K70.54211432
81MAP3K20.53268313
82LRRK20.53003846
83CDK190.51706979
84DYRK1B0.51365044
85ALK0.50729978
86RPS6KA10.48923345
87PDPK10.48720602
88CDK90.47092210
89SMG10.46950848
90RPS6KL10.46623327
91RPS6KC10.46623327
92PDK10.46536935
93CDC42BPA0.45457328
94RAF10.44896486
95BRD40.44790102
96MAPKAPK20.44198956
97SGK30.43788161
98MAP2K20.41711920
99STK110.40572394
100IGF1R0.38852749
101SGK20.38248997
102PDGFRB0.37926051
103INSR0.37894279
104MAP2K60.37891040
105PTK2B0.36989092
106RET0.36935429
107CDK40.35827375
108TAOK30.34478682
109MAPK120.34405891
110MAPK110.34115147
111EIF2AK20.33138448
112PTK60.33124470
113GSK3A0.32693345
114EGFR0.32402367
115PKN20.31957538
116TGFBR10.31421638
117ABL10.30934248
118BMPR20.30702137
119MAP3K80.30422840
120RPS6KA60.29709728
121HIPK20.27900701
122FLT30.26488754
123TRIB30.25671234
124TAOK20.24992415
125PAK20.24426264
126MAP3K50.23956096
127MAPK40.21972941
128STK40.21476066
129CDK60.21129231
130MAPK30.21118633
131TRPM70.20510382
132PASK0.19167446

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.44253644
2Allograft rejection_Homo sapiens_hsa053303.39119697
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.27157289
4Graft-versus-host disease_Homo sapiens_hsa053323.22502891
5NF-kappa B signaling pathway_Homo sapiens_hsa040643.04209871
6T cell receptor signaling pathway_Homo sapiens_hsa046602.90745073
7Leishmaniasis_Homo sapiens_hsa051402.66403890
8Measles_Homo sapiens_hsa051622.57285630
9Osteoclast differentiation_Homo sapiens_hsa043802.55983892
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.45944446
11Type I diabetes mellitus_Homo sapiens_hsa049402.21803198
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.18464865
13Antigen processing and presentation_Homo sapiens_hsa046122.13363985
14Autoimmune thyroid disease_Homo sapiens_hsa053201.99082355
15B cell receptor signaling pathway_Homo sapiens_hsa046621.94984826
16Asthma_Homo sapiens_hsa053101.93895408
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91916829
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.88676531
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.83616058
20Staphylococcus aureus infection_Homo sapiens_hsa051501.81068821
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79412708
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.78720668
23Legionellosis_Homo sapiens_hsa051341.75271250
24TNF signaling pathway_Homo sapiens_hsa046681.74623755
25Hematopoietic cell lineage_Homo sapiens_hsa046401.73064272
26Toxoplasmosis_Homo sapiens_hsa051451.72729301
27Herpes simplex infection_Homo sapiens_hsa051681.71460322
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.68679799
29Influenza A_Homo sapiens_hsa051641.52580522
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47385479
31Pertussis_Homo sapiens_hsa051331.47288727
32Hepatitis B_Homo sapiens_hsa051611.46687843
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37921348
34Chemokine signaling pathway_Homo sapiens_hsa040621.37777933
35Malaria_Homo sapiens_hsa051441.37140971
36Acute myeloid leukemia_Homo sapiens_hsa052211.33766306
37Viral myocarditis_Homo sapiens_hsa054161.30247744
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29116312
39Tuberculosis_Homo sapiens_hsa051521.26688400
40Apoptosis_Homo sapiens_hsa042101.20620121
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14897969
42Rheumatoid arthritis_Homo sapiens_hsa053231.13308225
43Chronic myeloid leukemia_Homo sapiens_hsa052201.12411198
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10515389
45Salmonella infection_Homo sapiens_hsa051321.08000677
46Shigellosis_Homo sapiens_hsa051311.01269235
47Prolactin signaling pathway_Homo sapiens_hsa049170.98897044
48HTLV-I infection_Homo sapiens_hsa051660.96794728
49Epstein-Barr virus infection_Homo sapiens_hsa051690.96118013
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95126642
51Pancreatic cancer_Homo sapiens_hsa052120.91848915
52Other glycan degradation_Homo sapiens_hsa005110.90249558
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.87086630
54Hepatitis C_Homo sapiens_hsa051600.86284591
55African trypanosomiasis_Homo sapiens_hsa051430.82466729
56Viral carcinogenesis_Homo sapiens_hsa052030.78556281
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.76625261
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.71990606
59Prion diseases_Homo sapiens_hsa050200.70077253
60Colorectal cancer_Homo sapiens_hsa052100.68803517
61Platelet activation_Homo sapiens_hsa046110.68755909
62Small cell lung cancer_Homo sapiens_hsa052220.63828093
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63561203
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63144027
65Choline metabolism in cancer_Homo sapiens_hsa052310.61243424
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.60784766
67MAPK signaling pathway_Homo sapiens_hsa040100.59494869
68Dorso-ventral axis formation_Homo sapiens_hsa043200.57907593
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53962066
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53366903
71Regulation of autophagy_Homo sapiens_hsa041400.53318631
72Lysosome_Homo sapiens_hsa041420.50967313
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.50695130
74VEGF signaling pathway_Homo sapiens_hsa043700.48491669
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46876812
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45047129
77GnRH signaling pathway_Homo sapiens_hsa049120.43868940
78FoxO signaling pathway_Homo sapiens_hsa040680.42444001
79Notch signaling pathway_Homo sapiens_hsa043300.41996855
80Amoebiasis_Homo sapiens_hsa051460.41876461
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41810136
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39636215
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38520661
84ErbB signaling pathway_Homo sapiens_hsa040120.37967865
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37516561
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.37075639
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34852900
88Endocytosis_Homo sapiens_hsa041440.32139984
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.32054913
90Rap1 signaling pathway_Homo sapiens_hsa040150.30593489
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30017371
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29068997
93HIF-1 signaling pathway_Homo sapiens_hsa040660.28963871
94Insulin resistance_Homo sapiens_hsa049310.28848103
95p53 signaling pathway_Homo sapiens_hsa041150.27745675
96Ras signaling pathway_Homo sapiens_hsa040140.27484640
97Long-term potentiation_Homo sapiens_hsa047200.27100422
98Prostate cancer_Homo sapiens_hsa052150.25218675
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25121643
100Non-small cell lung cancer_Homo sapiens_hsa052230.24382854
101Renal cell carcinoma_Homo sapiens_hsa052110.24088999
102Spliceosome_Homo sapiens_hsa030400.23304242
103Non-homologous end-joining_Homo sapiens_hsa034500.21284160
104MicroRNAs in cancer_Homo sapiens_hsa052060.21016178
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20352574
106RNA degradation_Homo sapiens_hsa030180.18005147
107Type II diabetes mellitus_Homo sapiens_hsa049300.17793190
108mTOR signaling pathway_Homo sapiens_hsa041500.17277555
109Pathways in cancer_Homo sapiens_hsa052000.16331133
110Thyroid cancer_Homo sapiens_hsa052160.15694058
111Systemic lupus erythematosus_Homo sapiens_hsa053220.15421216
112Inositol phosphate metabolism_Homo sapiens_hsa005620.14774573
113Phagosome_Homo sapiens_hsa041450.14427637
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.12491781
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11420326
116Endometrial cancer_Homo sapiens_hsa052130.10905573

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