TAGLN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)7.08886395
2collagen fibril organization (GO:0030199)5.68333239
3wound healing, spreading of epidermal cells (GO:0035313)5.65409434
4sequestering of extracellular ligand from receptor (GO:0035581)5.55120252
5cell adhesion mediated by integrin (GO:0033627)5.28431767
6positive regulation of endothelial cell apoptotic process (GO:2000353)5.26687171
7endodermal cell differentiation (GO:0035987)5.14796846
8skin morphogenesis (GO:0043589)4.74978476
9protein heterotrimerization (GO:0070208)4.72543388
10wound healing, spreading of cells (GO:0044319)4.70785005
11negative regulation of fatty acid transport (GO:2000192)4.47983981
12cell migration involved in heart development (GO:0060973)4.38547082
13epithelial cell-cell adhesion (GO:0090136)4.21024035
14extracellular matrix assembly (GO:0085029)4.19038810
15endocardial cushion development (GO:0003197)4.10936350
16regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.10131974
17actin filament depolymerization (GO:0030042)4.06165214
18type B pancreatic cell proliferation (GO:0044342)3.98340724
19stress fiber assembly (GO:0043149)3.88281113
20cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.84997437
21regulation of plasminogen activation (GO:0010755)3.83648939
22protein localization to cell surface (GO:0034394)3.83084231
23apoptotic cell clearance (GO:0043277)3.76536556
24positive regulation of epithelial to mesenchymal transition (GO:0010718)3.76266850
25bone trabecula formation (GO:0060346)3.72931780
26basement membrane organization (GO:0071711)3.65206757
27peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.64484281
28platelet aggregation (GO:0070527)3.63023985
29peptidyl-proline hydroxylation (GO:0019511)3.62334993
30collagen metabolic process (GO:0032963)3.59359300
31extracellular fibril organization (GO:0043206)3.57943334
32positive regulation of blood vessel endothelial cell migration (GO:0043536)3.56832133
33craniofacial suture morphogenesis (GO:0097094)3.56076932
34negative regulation of smooth muscle cell migration (GO:0014912)3.54328223
35negative regulation of fibrinolysis (GO:0051918)3.53172990
36maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.50732852
37cell-substrate junction assembly (GO:0007044)3.50088098
38regulation of tight junction assembly (GO:2000810)3.48607757
39neuron projection extension involved in neuron projection guidance (GO:1902284)3.47874606
40axon extension involved in axon guidance (GO:0048846)3.47874606
41regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.47771395
42negative regulation of chondrocyte differentiation (GO:0032331)3.46712591
43mesodermal cell differentiation (GO:0048333)3.46266878
44barbed-end actin filament capping (GO:0051016)3.46188991
45collagen catabolic process (GO:0030574)3.44796439
46fibril organization (GO:0097435)3.44296751
47dermatan sulfate biosynthetic process (GO:0030208)3.43897257
48positive regulation of macrophage activation (GO:0043032)3.43188702
49adhesion of symbiont to host cell (GO:0044650)3.38914465
50virion attachment to host cell (GO:0019062)3.38914465
51adherens junction assembly (GO:0034333)3.37256335
52multicellular organismal macromolecule metabolic process (GO:0044259)3.36821926
53vascular endothelial growth factor signaling pathway (GO:0038084)3.34138189
54plasma membrane repair (GO:0001778)3.33865098
55protein retention in ER lumen (GO:0006621)3.33576875
56positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)3.32960491
57planar cell polarity pathway involved in neural tube closure (GO:0090179)3.32912161
58substrate-dependent cell migration (GO:0006929)3.31674991
59cellular response to vitamin (GO:0071295)3.31642652
60negative regulation of focal adhesion assembly (GO:0051895)3.28488741
61negative regulation of cell junction assembly (GO:1901889)3.28488741
62negative regulation of adherens junction organization (GO:1903392)3.28488741
63mesenchymal-epithelial cell signaling (GO:0060638)3.27804241
64substrate adhesion-dependent cell spreading (GO:0034446)3.24024446
65regulation of G0 to G1 transition (GO:0070316)3.22484323
66dermatan sulfate metabolic process (GO:0030205)3.21050259
67cellular response to vitamin D (GO:0071305)3.20233034
68extracellular matrix disassembly (GO:0022617)3.20146542
69multicellular organismal catabolic process (GO:0044243)3.18430186
70retina vasculature morphogenesis in camera-type eye (GO:0061299)3.17651218
71multicellular organismal metabolic process (GO:0044236)3.17629325
72COPI coating of Golgi vesicle (GO:0048205)3.16238467
73Golgi transport vesicle coating (GO:0048200)3.16238467
74hemidesmosome assembly (GO:0031581)3.15917143
75protein hydroxylation (GO:0018126)3.14674859
76fibroblast migration (GO:0010761)3.12524667
77cranial suture morphogenesis (GO:0060363)3.12173857
78glomerular basement membrane development (GO:0032836)3.10111652
79platelet degranulation (GO:0002576)3.09109549
80regulation of integrin-mediated signaling pathway (GO:2001044)3.08996715
81regulation of SMAD protein import into nucleus (GO:0060390)3.08834291
82regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.08640238
83cell migration involved in sprouting angiogenesis (GO:0002042)3.07173647
84chondrocyte development (GO:0002063)3.04925615
85negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.04723683
86tooth mineralization (GO:0034505)3.01821748
87metanephric mesenchyme development (GO:0072075)3.01498138
88hippo signaling (GO:0035329)2.99948516
89hypotonic response (GO:0006971)2.98412450
90cellular response to interferon-alpha (GO:0035457)2.96850652
91adhesion of symbiont to host (GO:0044406)2.96257341
92positive regulation of collagen biosynthetic process (GO:0032967)2.94971681
93renal filtration (GO:0097205)2.91620213
94cell-substrate adherens junction assembly (GO:0007045)2.90304719
95focal adhesion assembly (GO:0048041)2.90304719
96vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.89452307
97keratan sulfate catabolic process (GO:0042340)2.88222686
98positive regulation of SMAD protein import into nucleus (GO:0060391)2.87102979
99positive regulation of collagen metabolic process (GO:0010714)2.86872759
100positive regulation of cartilage development (GO:0061036)2.86611088
101heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.86498502
102venous blood vessel morphogenesis (GO:0048845)2.84294716
103smooth muscle tissue development (GO:0048745)2.83606091
104extracellular negative regulation of signal transduction (GO:1900116)2.82679267
105extracellular regulation of signal transduction (GO:1900115)2.82679267
106regulation of collagen metabolic process (GO:0010712)2.82108573
107kidney mesenchyme development (GO:0072074)2.82032454
108positive regulation of osteoblast proliferation (GO:0033690)2.80984989
109extracellular matrix organization (GO:0030198)2.80191663
110negative regulation of anoikis (GO:2000811)2.79593931
111extracellular structure organization (GO:0043062)2.78910144
112negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.78908629
113regulation of hippo signaling (GO:0035330)2.78760729
114atrioventricular valve morphogenesis (GO:0003181)2.75889844
115actin-myosin filament sliding (GO:0033275)2.75740377
116muscle filament sliding (GO:0030049)2.75740377
117paraxial mesoderm development (GO:0048339)2.75654145
118endothelial cell morphogenesis (GO:0001886)2.74033352
119negative regulation of BMP signaling pathway (GO:0030514)2.73778249
120response to fluid shear stress (GO:0034405)2.72918233
121positive regulation of actin filament depolymerization (GO:0030836)2.72385134
122wound healing (GO:0042060)2.71803654
123actin-mediated cell contraction (GO:0070252)2.71780949
124lymphangiogenesis (GO:0001946)2.71064435
125chondroitin sulfate biosynthetic process (GO:0030206)2.70366941
126negative regulation of cartilage development (GO:0061037)2.69887173
127cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.68560724
128trabecula formation (GO:0060343)2.67948995
129regulation of osteoblast proliferation (GO:0033688)2.67046887
130sprouting angiogenesis (GO:0002040)2.65340268
131muscle cell migration (GO:0014812)2.63040264
132cell-substrate adhesion (GO:0031589)2.61776601
133Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.60245334
134positive regulation of axon extension (GO:0045773)2.58662807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.23338093
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.15164973
3RARG_19884340_ChIP-ChIP_MEFs_Mouse5.27880063
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.79018754
5CLOCK_20551151_ChIP-Seq_293T_Human3.49319866
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.05157212
7RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.98470607
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.80365508
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.73815562
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72029220
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.51057266
12CJUN_26792858_Chip-Seq_BT549_Human2.44553914
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.26216585
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.23707682
15CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.20915284
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.20668751
17SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.19030365
18SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.19030365
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.15323139
20BRD4_25478319_ChIP-Seq_HGPS_Human2.08469927
21SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.05553991
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.03913539
23WT1_19549856_ChIP-ChIP_CCG9911_Human2.02423536
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.99175236
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.96053397
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.94571355
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.94512841
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.89954724
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89258463
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87690852
31CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.82373376
32ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.81506842
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.72436673
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70620732
35* SOX2_20726797_ChIP-Seq_SW620_Human1.70162588
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69988568
37JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69899101
38ATF3_27146783_Chip-Seq_COLON_Human1.67897776
39MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.65860010
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.65423501
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.65423501
42TP53_22127205_ChIP-Seq_IMR90_Human1.62419121
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.62407582
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62227804
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56882068
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56882068
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.56115041
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55658561
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55526793
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.54356868
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53841555
52SMC1_22415368_ChIP-Seq_MEFs_Mouse1.53773565
53* RACK7_27058665_Chip-Seq_MCF-7_Human1.51841405
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50676705
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50218475
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49014899
57JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48293408
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.48163230
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.47405350
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44222800
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39927354
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37588169
63UBF1/2_26484160_Chip-Seq_HMECs_Human1.37139227
64TP53_23651856_ChIP-Seq_MEFs_Mouse1.36541283
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35135381
66NFIB_24661679_ChIP-Seq_LUNG_Mouse1.33454211
67TP53_16413492_ChIP-PET_HCT116_Human1.32890712
68TP53_18474530_ChIP-ChIP_U2OS_Human1.32613452
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.32117803
70TBX20_22328084_ChIP-Seq_HEART_Mouse1.27478959
71TBX20_22080862_ChIP-Seq_HEART_Mouse1.27478959
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.27454387
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24840193
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24656998
75MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21364933
76P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19553912
77SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18567863
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18216660
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18158954
80NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17589187
81EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.17058647
82* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.15960367
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15665561
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14755204
85KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10227469
86KDM2B_26808549_Chip-Seq_K562_Human1.09384052
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07492443
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05514458
89JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04895574
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04124884
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03728987
92* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02896117
93RNF2_27304074_Chip-Seq_ESCs_Mouse1.02139828
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02094629
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01657134
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.01347200
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00501071
98ESR1_20079471_ChIP-ChIP_T-47D_Human0.99435184
99KLF5_25053715_ChIP-Seq_YYC3_Human0.98784454
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97810597
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97355458
102SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97076040
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96939960
104SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96349314
105LXR_22292898_ChIP-Seq_THP-1_Human0.94973431
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94617941
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92500008
108TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92471414
109RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92445120
110TET1_21490601_ChIP-Seq_MESCs_Mouse0.91498614
111SA1_22415368_ChIP-Seq_MEFs_Mouse0.89842922
112ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89450903
113NFI_21473784_ChIP-Seq_ESCs_Mouse0.88516065
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87330491
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85932481
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84476465
117EED_16625203_ChIP-ChIP_MESCs_Mouse0.84385419
118DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83847363
119CSB_26484114_Chip-Seq_FIBROBLAST_Human0.82661651
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81414430
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.79748567
122RUNX1_27514584_Chip-Seq_MCF-7_Human0.78841069
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78271319
124GATA3_24758297_ChIP-Seq_MCF-7_Human0.76205746

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.78665133
2MP0005275_abnormal_skin_tensile4.06224009
3MP0003705_abnormal_hypodermis_morpholog3.90091074
4MP0003279_aneurysm3.79807355
5MP0005503_abnormal_tendon_morphology3.47581021
6MP0003566_abnormal_cell_adhesion3.21259880
7MP0005623_abnormal_meninges_morphology3.10711639
8MP0001958_emphysema2.89924794
9MP0006054_spinal_hemorrhage2.87269150
10MP0004272_abnormal_basement_membrane2.86564207
11MP0010352_gastrointestinal_tract_polyps2.72085933
12MP0009384_cardiac_valve_regurgitation2.65501908
13MP0000516_abnormal_urinary_system2.45567611
14MP0005367_renal/urinary_system_phenotyp2.45567611
15MP0005023_abnormal_wound_healing2.33853095
16MP0000013_abnormal_adipose_tissue2.26136084
17MP0003091_abnormal_cell_migration2.09868847
18MP0010030_abnormal_orbit_morphology1.98090831
19MP0005257_abnormal_intraocular_pressure1.89198310
20MP0002295_abnormal_pulmonary_circulatio1.88377339
21MP0003385_abnormal_body_wall1.85116176
22MP0005508_abnormal_skeleton_morphology1.82032698
23MP0001542_abnormal_bone_strength1.79558155
24MP0010386_abnormal_urinary_bladder1.71401595
25MP0000767_abnormal_smooth_muscle1.66139869
26MP0003941_abnormal_skin_development1.65977484
27MP0009053_abnormal_anal_canal1.58388622
28MP0002060_abnormal_skin_morphology1.57418654
29MP0000534_abnormal_ureter_morphology1.55789063
30MP0009250_abnormal_appendicular_skeleto1.53581169
31MP0002254_reproductive_system_inflammat1.52093262
32MP0004084_abnormal_cardiac_muscle1.48514994
33MP0010368_abnormal_lymphatic_system1.45538205
34MP0003045_fibrosis1.42322959
35MP0004858_abnormal_nervous_system1.39758328
36MP0001348_abnormal_lacrimal_gland1.37419359
37MP0000750_abnormal_muscle_regeneration1.37414303
38MP0001243_abnormal_dermal_layer1.33927438
39MP0000733_abnormal_muscle_development1.31927519
40MP0005330_cardiomyopathy1.28585004
41MP0001299_abnormal_eye_distance/1.25858337
42MP0003942_abnormal_urinary_system1.21359944
43MP0002877_abnormal_melanocyte_morpholog1.20904325
44MP0000537_abnormal_urethra_morphology1.20829026
45MP0009780_abnormal_chondrocyte_physiolo1.19597135
46MP0000749_muscle_degeneration1.18109471
47MP0005164_abnormal_response_to1.17244757
48MP0002896_abnormal_bone_mineralization1.15760559
49MP0002282_abnormal_trachea_morphology1.14232941
50MP0003950_abnormal_plasma_membrane1.12573021
51MP0005595_abnormal_vascular_smooth1.10319251
52MP0006138_congestive_heart_failure1.08601154
53MP0005390_skeleton_phenotype1.08534637
54MP0000003_abnormal_adipose_tissue1.07149699
55MP0005620_abnormal_muscle_contractility1.07066860
56MP0001849_ear_inflammation1.06052368
57MP0000163_abnormal_cartilage_morphology1.04147637
58MP0008004_abnormal_stomach_pH1.00645523
59MP0002128_abnormal_blood_circulation0.99065143
60MP0001614_abnormal_blood_vessel0.98450301
61MP0003115_abnormal_respiratory_system0.98154554
62MP0004087_abnormal_muscle_fiber0.97850509
63MP0000858_altered_metastatic_potential0.95969712
64MP0002168_other_aberrant_phenotype0.95328066
65MP0003755_abnormal_palate_morphology0.94420260
66MP0004036_abnormal_muscle_relaxation0.93082487
67MP0002115_abnormal_skeleton_extremities0.92743557
68MP0001879_abnormal_lymphatic_vessel0.92211055
69MP0003283_abnormal_digestive_organ0.90148523
70MP0002108_abnormal_muscle_morphology0.88969630
71MP0002113_abnormal_skeleton_development0.88274924
72MP0002932_abnormal_joint_morphology0.86743117
73MP0004134_abnormal_chest_morphology0.85556570
74MP0003300_gastrointestinal_ulcer0.85060899
75MP0001533_abnormal_skeleton_physiology0.84563703
76MP0002925_abnormal_cardiovascular_devel0.84202611
77MP0000538_abnormal_urinary_bladder0.83177121
78MP0002972_abnormal_cardiac_muscle0.82831910
79MP0008775_abnormal_heart_ventricle0.80999239
80MP0010630_abnormal_cardiac_muscle0.79779974
81MP0000462_abnormal_digestive_system0.78795550
82MP0000751_myopathy0.78707221
83MP0002133_abnormal_respiratory_system0.77996553
84MP0005388_respiratory_system_phenotype0.77996553
85MP0004883_abnormal_blood_vessel0.76840305
86MP0000428_abnormal_craniofacial_morphol0.76658690
87MP0002089_abnormal_postnatal_growth/wei0.75858420
88MP0003448_altered_tumor_morphology0.74655038
89MP0001915_intracranial_hemorrhage0.74366400
90MP0005171_absent_coat_pigmentation0.73368663
91MP0005197_abnormal_uvea_morphology0.72616829
92MP0000049_abnormal_middle_ear0.72286882
93MP0001175_abnormal_lung_morphology0.71790956
94MP0000759_abnormal_skeletal_muscle0.69543222
95MP0003935_abnormal_craniofacial_develop0.69531798
96MP0005084_abnormal_gallbladder_morpholo0.68971769
97MP0005375_adipose_tissue_phenotype0.68684936
98MP0001544_abnormal_cardiovascular_syste0.68409072
99MP0005385_cardiovascular_system_phenoty0.68409072
100MP0003828_pulmonary_edema0.68385276
101MP0000249_abnormal_blood_vessel0.68206057
102MP0002933_joint_inflammation0.67983064
103MP0005193_abnormal_anterior_eye0.66060216
104MP0002111_abnormal_tail_morphology0.65999168
105MP0003795_abnormal_bone_structure0.65838777
106MP0000343_altered_response_to0.65283813
107MP0002998_abnormal_bone_remodeling0.65267728
108MP0000432_abnormal_head_morphology0.64893334
109MP0000266_abnormal_heart_morphology0.63974205
110MP0000467_abnormal_esophagus_morphology0.63837036
111MP0001756_abnormal_urination0.63347187
112MP0000230_abnormal_systemic_arterial0.63106500
113MP0000762_abnormal_tongue_morphology0.62574982
114MP0002114_abnormal_axial_skeleton0.59645344
115MP0005165_increased_susceptibility_to0.58813099
116MP0002116_abnormal_craniofacial_bone0.57101094
117MP0005409_darkened_coat_color0.56272161
118MP0005369_muscle_phenotype0.55330314
119MP0002127_abnormal_cardiovascular_syste0.53346517

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.86333441
2Protrusio acetabuli (HP:0003179)7.44371111
3Aortic dissection (HP:0002647)6.96857223
4Aortic aneurysm (HP:0004942)6.85596182
5Cerebral aneurysm (HP:0004944)4.95041138
6Peritonitis (HP:0002586)4.54233616
7Dilatation of the ascending aorta (HP:0005111)4.21602981
8Shallow orbits (HP:0000586)4.18437162
9Atrophic scars (HP:0001075)4.13223151
10Ankle contracture (HP:0006466)3.90568957
11Soft skin (HP:0000977)3.88219259
12Abnormality of dentin (HP:0010299)3.87366395
13Fragile skin (HP:0001030)3.51987846
14Wormian bones (HP:0002645)3.40979179
15Increased density of long bones (HP:0006392)3.31936738
16Cervical subluxation (HP:0003308)3.30858976
17Bladder diverticulum (HP:0000015)3.26992700
18Vertebral compression fractures (HP:0002953)3.18957222
19Blue sclerae (HP:0000592)3.16513446
20Spinal rigidity (HP:0003306)3.16421837
21Gastrointestinal dysmotility (HP:0002579)3.14618071
22Mitral valve prolapse (HP:0001634)3.13335003
23Aneurysm (HP:0002617)3.12088946
24Type 1 muscle fiber predominance (HP:0003803)3.11051852
25Biconcave vertebral bodies (HP:0004586)3.07119829
26Broad metatarsal (HP:0001783)3.04538121
27Right ventricular cardiomyopathy (HP:0011663)2.97303362
28Vascular tortuosity (HP:0004948)2.93443197
29Increased connective tissue (HP:0009025)2.92975362
30Wrist flexion contracture (HP:0001239)2.91860908
31Genu recurvatum (HP:0002816)2.89435480
32Scapular winging (HP:0003691)2.81825836
33Slender build (HP:0001533)2.81170434
34Aortic regurgitation (HP:0001659)2.79816249
35Neonatal short-limb short stature (HP:0008921)2.73402391
36Abnormality of the calcaneus (HP:0008364)2.69392559
37Radial bowing (HP:0002986)2.66132617
38Camptodactyly of toe (HP:0001836)2.65882981
39Mesomelia (HP:0003027)2.63731044
40Elbow flexion contracture (HP:0002987)2.63248766
41Abnormal delivery (HP:0001787)2.62653677
42Short nail (HP:0001799)2.62464621
43Ulnar bowing (HP:0003031)2.57276510
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.55411491
45Osteolytic defects of the hand bones (HP:0009699)2.55411491
46Round ear (HP:0100830)2.46892243
47Arterial tortuosity (HP:0005116)2.42993101
48Broad face (HP:0000283)2.40420976
49Bowel diverticulosis (HP:0005222)2.38954088
50Abnormality of the acetabulum (HP:0003170)2.38179036
51Aortic valve stenosis (HP:0001650)2.37529764
52Hyperextensible skin (HP:0000974)2.32176311
53Infantile muscular hypotonia (HP:0008947)2.31650408
54Hypoventilation (HP:0002791)2.31041192
55Overgrowth (HP:0001548)2.28268349
56Mitral regurgitation (HP:0001653)2.27083076
57Tarsal synostosis (HP:0008368)2.24728917
58Facial diplegia (HP:0001349)2.23428352
59Wide anterior fontanel (HP:0000260)2.20472598
60Increased mean platelet volume (HP:0011877)2.19051992
61Bowing of the arm (HP:0006488)2.17969747
62Bowed forearm bones (HP:0003956)2.17969747
63Disproportionate tall stature (HP:0001519)2.15313426
64Short hallux (HP:0010109)2.13340681
65Mildly elevated creatine phosphokinase (HP:0008180)2.13013043
66Malnutrition (HP:0004395)2.12459829
67Increased variability in muscle fiber diameter (HP:0003557)2.11894430
68Distal upper limb amyotrophy (HP:0007149)2.11436379
69Upper limb amyotrophy (HP:0009129)2.11436379
70Coronal craniosynostosis (HP:0004440)2.10178474
71Knee flexion contracture (HP:0006380)2.09832886
72Mild short stature (HP:0003502)2.09708868
73Spondylolisthesis (HP:0003302)2.07658458
74Tibial bowing (HP:0002982)2.06745375
75Pulmonary artery stenosis (HP:0004415)2.04986700
76Flexion contracture of toe (HP:0005830)2.03034771
77Joint contractures involving the joints of the feet (HP:0100492)2.03034771
78Thin bony cortex (HP:0002753)2.02554798
79Persistence of primary teeth (HP:0006335)2.00937391
80Ectopia lentis (HP:0001083)1.99085913
81Nonimmune hydrops fetalis (HP:0001790)1.98599454
82Absent frontal sinuses (HP:0002688)1.98106066
83Synostosis involving bones of the feet (HP:0009140)1.97099053
84Synostosis involving bones of the lower limbs (HP:0009138)1.97099053
85Calcaneovalgus deformity (HP:0001848)1.95715868
86Hypoplasia of the iris (HP:0007676)1.95315620
87Hyporeflexia of lower limbs (HP:0002600)1.95061513
88Aplasia/Hypoplasia of the hallux (HP:0008362)1.95031914
89Abnormality of the peritoneum (HP:0002585)1.93990826
90Difficulty climbing stairs (HP:0003551)1.93704027
91Neoplasm of the heart (HP:0100544)1.92581262
92Long toe (HP:0010511)1.92496876
93Follicular hyperkeratosis (HP:0007502)1.91093916
94Mitral stenosis (HP:0001718)1.90812129
95Muscle fiber splitting (HP:0003555)1.90771566
96Deviation of the hallux (HP:0010051)1.89502462
97Bicuspid aortic valve (HP:0001647)1.89357129
98Distal lower limb amyotrophy (HP:0008944)1.89264975
99Breech presentation (HP:0001623)1.88468985
100Abnormality of skeletal muscle fiber size (HP:0012084)1.88189992
101Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.88011405
102Short 4th metacarpal (HP:0010044)1.88011405
103Hip contracture (HP:0003273)1.86897951
104Premature skin wrinkling (HP:0100678)1.86684345
105Osteoarthritis (HP:0002758)1.86070171
106Inguinal hernia (HP:0000023)1.86047131
107Joint laxity (HP:0001388)1.85125225
108Fused cervical vertebrae (HP:0002949)1.83682380
109Renal duplication (HP:0000075)1.83415808
110Broad ribs (HP:0000885)1.83393312
111Limited hip movement (HP:0008800)1.81931564
112Buphthalmos (HP:0000557)1.81718898
113Abnormal platelet volume (HP:0011876)1.81715195
114Broad long bones (HP:0005622)1.80828852
115Hallux valgus (HP:0001822)1.80787427
116Chondrocalcinosis (HP:0000934)1.79917858
117Joint stiffness (HP:0001387)1.79004492
118Arachnodactyly (HP:0001166)1.78328378
119Selective tooth agenesis (HP:0001592)1.77444968
120Hydroureter (HP:0000072)1.75735577
121Generalized amyotrophy (HP:0003700)1.72994396
122Venous insufficiency (HP:0005293)1.71953741
123Venous abnormality (HP:0002624)1.71860692
124Ulnar deviation of the wrist (HP:0003049)1.69515820
125Deformed tarsal bones (HP:0008119)1.69130927
126Thin ribs (HP:0000883)1.69107470
127Delayed cranial suture closure (HP:0000270)1.68621234
128Bradycardia (HP:0001662)1.67588415
129Natal tooth (HP:0000695)1.66687723
130Redundant skin (HP:0001582)1.66153490

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK6.41381734
2TTN5.44487126
3TESK13.32355336
4TRIB33.30011011
5PAK23.18647943
6LIMK12.80184465
7DDR22.76386947
8DMPK2.71393356
9PIK3CG2.61267572
10LATS22.41885050
11PDGFRA2.41656126
12EPHB22.23094276
13PIK3CA2.20996936
14LATS12.12404705
15ERN12.11723704
16PKN21.98423527
17PTK21.78112309
18DAPK31.77867370
19PTK2B1.74700635
20PIM21.73388432
21CDC42BPA1.69310875
22PAK31.65350838
23EPHA21.61419099
24TRPM71.52980996
25ILK1.48894669
26STK38L1.47982048
27MAPKAPK31.42048760
28LRRK21.39899642
29ROCK11.32516500
30RIPK11.32033087
31FER1.29292214
32STK381.25809321
33BMX1.17161853
34MAP3K61.14788814
35PAK11.14362604
36PTK61.13346122
37TESK21.12456427
38MET1.10548779
39NUAK10.96970755
40MUSK0.90857760
41FRK0.90825608
42TIE10.84266309
43EEF2K0.81383321
44STK30.79597205
45MAPK70.78468835
46PAK40.77276947
47EPHA30.76846484
48GRK70.76220866
49KIT0.75817032
50MAP2K10.73914042
51SIK10.73786490
52MAP3K30.72865638
53FGFR40.69451592
54ROCK20.69300654
55MOS0.68229275
56RPS6KB20.66315571
57PDGFRB0.66182048
58GSK3A0.66169465
59STK100.65679375
60PRKG20.65580958
61TGFBR20.65426280
62FGFR10.63252303
63LMTK20.63186471
64MTOR0.60786916
65RPS6KA40.60630956
66ICK0.57033958
67INSR0.55508931
68KDR0.55319410
69ADRBK10.55084390
70ZAK0.54733724
71NTRK10.53940504
72ERBB30.53798855
73MAP3K70.53259202
74MARK20.53228615
75WNK10.52061506
76MAP3K120.50580674
77SMG10.50502005
78TAOK10.50093382
79MAP2K30.48634140
80MINK10.48323784
81PAK60.47075619
82MAP3K80.46215838
83NEK90.45803007
84PRKD10.45042964
85AKT30.44921614
86ABL20.44397109
87MELK0.42982394
88RPS6KA20.42429482
89CLK10.41955188
90MAPKAPK20.41592621
91MAPK40.39047263
92MST1R0.38369946
93ARAF0.37347030
94MAP3K100.35914103
95OBSCN0.35822023
96FLT30.34832240
97CDK140.33681505
98SCYL20.33552138
99PDK20.33436807
100RET0.32931344
101CAMK2G0.32807610
102EPHB10.32698270
103STK240.32353524
104SRC0.32331307
105PRKCH0.32210850
106EGFR0.30814299
107TAOK20.30673281
108RAF10.29822842
109JAK10.28646796
110DYRK1B0.27834590
111CAMK2D0.27652000
112FYN0.27339706
113CDK150.27145297
114CDK60.26186302
115PRKCE0.26117539
116CAMK2B0.26041445
117KSR20.24017252
118CAMK10.23958242
119ZAP700.23866324
120ERBB40.23189546
121PRKD20.23184558
122CDK180.23003418
123CDK11A0.21595205
124NME20.21395622
125RPS6KL10.20266540
126RPS6KC10.20266540
127NEK10.18743454
128PRKD30.16961751
129MAPKAPK50.16415258
130RPS6KA60.15754081

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.98433936
2Focal adhesion_Homo sapiens_hsa045103.63818749
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.17350703
4Bladder cancer_Homo sapiens_hsa052193.01711565
5Dilated cardiomyopathy_Homo sapiens_hsa054142.89065248
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.69700178
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.65463345
8Proteoglycans in cancer_Homo sapiens_hsa052052.62323951
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.49239048
10Amoebiasis_Homo sapiens_hsa051462.42080918
11TGF-beta signaling pathway_Homo sapiens_hsa043502.40168059
12Adherens junction_Homo sapiens_hsa045202.32421256
13Hippo signaling pathway_Homo sapiens_hsa043902.18556025
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.15162347
15Vascular smooth muscle contraction_Homo sapiens_hsa042701.98189358
16Regulation of actin cytoskeleton_Homo sapiens_hsa048101.97910767
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.94086191
18Tight junction_Homo sapiens_hsa045301.87499317
19Small cell lung cancer_Homo sapiens_hsa052221.80116451
20Protein digestion and absorption_Homo sapiens_hsa049741.77688729
21MicroRNAs in cancer_Homo sapiens_hsa052061.72452005
22Malaria_Homo sapiens_hsa051441.72427709
23Shigellosis_Homo sapiens_hsa051311.69922749
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.56655611
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.53991756
26p53 signaling pathway_Homo sapiens_hsa041151.48617379
27Chronic myeloid leukemia_Homo sapiens_hsa052201.46794586
28PI3K-Akt signaling pathway_Homo sapiens_hsa041511.43542808
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35052749
30Platelet activation_Homo sapiens_hsa046111.26628587
31Basal cell carcinoma_Homo sapiens_hsa052171.17425234
32Melanoma_Homo sapiens_hsa052181.14909808
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12433924
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08500988
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08015179
36HIF-1 signaling pathway_Homo sapiens_hsa040661.05968156
37Rap1 signaling pathway_Homo sapiens_hsa040151.05214356
38Salmonella infection_Homo sapiens_hsa051320.99544976
39Prion diseases_Homo sapiens_hsa050200.98793780
40Viral myocarditis_Homo sapiens_hsa054160.97952265
41Other glycan degradation_Homo sapiens_hsa005110.95440075
42Phagosome_Homo sapiens_hsa041450.93467727
43Pancreatic cancer_Homo sapiens_hsa052120.91237057
44Pathways in cancer_Homo sapiens_hsa052000.91107578
45Hedgehog signaling pathway_Homo sapiens_hsa043400.86387997
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83112825
47Glioma_Homo sapiens_hsa052140.82270327
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81671047
49Prostate cancer_Homo sapiens_hsa052150.80078616
50TNF signaling pathway_Homo sapiens_hsa046680.80024730
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77766060
52HTLV-I infection_Homo sapiens_hsa051660.77653410
53Toxoplasmosis_Homo sapiens_hsa051450.75800973
54Notch signaling pathway_Homo sapiens_hsa043300.74324328
55Apoptosis_Homo sapiens_hsa042100.71893822
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71669838
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.70648164
58Wnt signaling pathway_Homo sapiens_hsa043100.68501249
59Gap junction_Homo sapiens_hsa045400.68336150
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67403908
61N-Glycan biosynthesis_Homo sapiens_hsa005100.66855999
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66531121
63Axon guidance_Homo sapiens_hsa043600.64178846
64Oxytocin signaling pathway_Homo sapiens_hsa049210.64047407
65Leishmaniasis_Homo sapiens_hsa051400.62725591
66VEGF signaling pathway_Homo sapiens_hsa043700.62410696
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61934513
68Renal cell carcinoma_Homo sapiens_hsa052110.61639123
69Renin secretion_Homo sapiens_hsa049240.61043035
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59779847
71Thyroid hormone synthesis_Homo sapiens_hsa049180.59358712
72Endocytosis_Homo sapiens_hsa041440.58901250
73Melanogenesis_Homo sapiens_hsa049160.57946768
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57865241
75Vibrio cholerae infection_Homo sapiens_hsa051100.57096380
76Pertussis_Homo sapiens_hsa051330.56611439
77Cocaine addiction_Homo sapiens_hsa050300.54608664
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53454905
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.52209341
80Endometrial cancer_Homo sapiens_hsa052130.51913379
81Viral carcinogenesis_Homo sapiens_hsa052030.51851378
82Thyroid cancer_Homo sapiens_hsa052160.51628263
83Colorectal cancer_Homo sapiens_hsa052100.51307886
84Cardiac muscle contraction_Homo sapiens_hsa042600.50718832
85cAMP signaling pathway_Homo sapiens_hsa040240.49578031
86Renin-angiotensin system_Homo sapiens_hsa046140.46468943
87Hepatitis B_Homo sapiens_hsa051610.46024836
88Gastric acid secretion_Homo sapiens_hsa049710.45804604
89Estrogen signaling pathway_Homo sapiens_hsa049150.45193063
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44617102
91FoxO signaling pathway_Homo sapiens_hsa040680.44537425
92GnRH signaling pathway_Homo sapiens_hsa049120.43567980
93Ras signaling pathway_Homo sapiens_hsa040140.43442752
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.43092301
95Glutathione metabolism_Homo sapiens_hsa004800.40609975
96Lysosome_Homo sapiens_hsa041420.40473608
97Sulfur metabolism_Homo sapiens_hsa009200.40017130
98ErbB signaling pathway_Homo sapiens_hsa040120.38939504
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35899378
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35836278
101Glucagon signaling pathway_Homo sapiens_hsa049220.35218977
102Complement and coagulation cascades_Homo sapiens_hsa046100.35097857
103Arachidonic acid metabolism_Homo sapiens_hsa005900.34443298
104Calcium signaling pathway_Homo sapiens_hsa040200.33363239
105AMPK signaling pathway_Homo sapiens_hsa041520.33003964
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.31059925
107Protein export_Homo sapiens_hsa030600.30662396
108Insulin resistance_Homo sapiens_hsa049310.29862175
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29724003
110Dorso-ventral axis formation_Homo sapiens_hsa043200.29701140
111MAPK signaling pathway_Homo sapiens_hsa040100.29630537
112mTOR signaling pathway_Homo sapiens_hsa041500.29586525
113Insulin signaling pathway_Homo sapiens_hsa049100.28437538
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.27146247
115Ovarian steroidogenesis_Homo sapiens_hsa049130.27120940
116Galactose metabolism_Homo sapiens_hsa000520.24697542

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