TAGLN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.89593044
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.89593044
3negative regulation of cell killing (GO:0031342)4.62856642
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.62856642
5antigen processing and presentation of endogenous antigen (GO:0019883)4.52861676
6ribosomal small subunit assembly (GO:0000028)4.44462258
7positive regulation by symbiont of host defense response (GO:0052509)4.18483221
8modulation by symbiont of host defense response (GO:0052031)4.18483221
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.18483221
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.18483221
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.18483221
12modulation by symbiont of host immune response (GO:0052553)4.18483221
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.97756937
14Arp2/3 complex-mediated actin nucleation (GO:0034314)3.92988080
15detection of other organism (GO:0098543)3.89700409
16detection of bacterium (GO:0016045)3.86781301
17negative regulation of erythrocyte differentiation (GO:0045647)3.77575531
18neutrophil activation involved in immune response (GO:0002283)3.69219198
19response to interferon-beta (GO:0035456)3.48103850
20regulation of mast cell degranulation (GO:0043304)3.37497891
21immunoglobulin mediated immune response (GO:0016064)3.29403708
22regulation of B cell receptor signaling pathway (GO:0050855)3.28753988
23viral transcription (GO:0019083)3.24878854
24macrophage activation involved in immune response (GO:0002281)3.14587933
25translational termination (GO:0006415)3.14526965
26detection of external biotic stimulus (GO:0098581)3.14296263
27antigen processing and presentation via MHC class Ib (GO:0002475)3.12808224
28regulation of leukocyte degranulation (GO:0043300)3.10010137
29response to interferon-alpha (GO:0035455)3.08018615
30positive regulation of natural killer cell differentiation (GO:0032825)3.07878726
31regulation of T-helper 1 cell differentiation (GO:0045625)3.06993453
32B cell mediated immunity (GO:0019724)3.04832782
33regulation of myeloid leukocyte mediated immunity (GO:0002886)3.04671902
34regulation of mast cell activation involved in immune response (GO:0033006)3.01758094
35cellular response to type I interferon (GO:0071357)3.01249562
36type I interferon signaling pathway (GO:0060337)3.01249562
37response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.99944676
38response to host (GO:0075136)2.99944676
39response to host defenses (GO:0052200)2.99944676
40response to type I interferon (GO:0034340)2.99852870
41response to peptidoglycan (GO:0032494)2.98885470
42response to host immune response (GO:0052572)2.97053245
43response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.97053245
44cellular extravasation (GO:0045123)2.96631504
45positive regulation of Cdc42 GTPase activity (GO:0043089)2.95170295
46SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.95152527
47actin nucleation (GO:0045010)2.94449564
48myeloid dendritic cell activation (GO:0001773)2.93487260
49negative regulation of interleukin-12 production (GO:0032695)2.92980598
50negative regulation of lymphocyte mediated immunity (GO:0002707)2.92727959
51cellular response to interferon-beta (GO:0035458)2.91127689
52regulation of interferon-beta biosynthetic process (GO:0045357)2.90578951
53leukocyte migration involved in inflammatory response (GO:0002523)2.89092155
54T cell apoptotic process (GO:0070231)2.87468472
55cellular response to zinc ion (GO:0071294)2.87292263
56negative regulation of phagocytosis (GO:0050765)2.87016189
57regulation of gamma-delta T cell activation (GO:0046643)2.86872607
58positive regulation of gamma-delta T cell activation (GO:0046645)2.86553985
59protein targeting to ER (GO:0045047)2.85064764
60myeloid cell activation involved in immune response (GO:0002275)2.84258736
61cotranslational protein targeting to membrane (GO:0006613)2.83427718
62NIK/NF-kappaB signaling (GO:0038061)2.83298507
63response to protozoan (GO:0001562)2.83030415
64negative regulation of leukocyte mediated immunity (GO:0002704)2.81634722
65leukocyte degranulation (GO:0043299)2.81256686
66positive regulation of interferon-alpha production (GO:0032727)2.76060743
67translational elongation (GO:0006414)2.75969533
68regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.75934927
69myeloid dendritic cell differentiation (GO:0043011)2.74735176
70positive regulation of T cell mediated cytotoxicity (GO:0001916)2.74624730
71defense response to protozoan (GO:0042832)2.74356537
72positive regulation of B cell differentiation (GO:0045579)2.72707781
73positive regulation of mast cell activation (GO:0033005)2.71990501
74regulation of platelet aggregation (GO:0090330)2.71472355
75detection of biotic stimulus (GO:0009595)2.70719776
76response to muramyl dipeptide (GO:0032495)2.69375914
77positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68408084
78establishment of protein localization to endoplasmic reticulum (GO:0072599)2.68112036
79negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.67637520
80germinal center formation (GO:0002467)2.67577755
81positive regulation of macrophage differentiation (GO:0045651)2.67008491
82regulation of interleukin-12 biosynthetic process (GO:0045075)2.66883435
83protein localization to endoplasmic reticulum (GO:0070972)2.66505736
84pentose-phosphate shunt (GO:0006098)2.66153423
85neutrophil activation (GO:0042119)2.65583291
86maturation of SSU-rRNA (GO:0030490)2.64707092
87positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.64452797
88negative regulation of stress fiber assembly (GO:0051497)2.64267056
89regulation of gamma-delta T cell differentiation (GO:0045586)2.63667644
90positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.62980970
91detection of molecule of bacterial origin (GO:0032490)2.62673197
92regulation of protein heterodimerization activity (GO:0043497)2.62080451
93telomere maintenance via semi-conservative replication (GO:0032201)2.61693873
94B cell receptor signaling pathway (GO:0050853)2.61281983
95platelet aggregation (GO:0070527)2.60828785
96ribosomal small subunit biogenesis (GO:0042274)2.59979331
97response to interleukin-15 (GO:0070672)2.59625250
98DNA strand elongation involved in DNA replication (GO:0006271)2.59378297
99regulation of interferon-alpha production (GO:0032647)2.59353605
100negative regulation of glycoprotein biosynthetic process (GO:0010561)2.59138961
101granulocyte activation (GO:0036230)2.57983324
102negative regulation of viral genome replication (GO:0045071)2.57552978
103regulation of T cell mediated cytotoxicity (GO:0001914)2.57326361
104natural killer cell mediated cytotoxicity (GO:0042267)2.56830977
105natural killer cell mediated immunity (GO:0002228)2.56830977
106hepatocyte apoptotic process (GO:0097284)2.55378412
107viral life cycle (GO:0019058)2.54995453
108regulation of dendritic cell antigen processing and presentation (GO:0002604)2.54790570
109antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.54474685
110tolerance induction (GO:0002507)2.54032556
111T-helper 1 type immune response (GO:0042088)2.53965508
112regulation of superoxide anion generation (GO:0032928)2.53778617
113membrane raft organization (GO:0031579)2.53286244
114positive regulation of antigen processing and presentation (GO:0002579)2.51423507
115DNA deamination (GO:0045006)2.51277777
116regulation of T-helper 2 cell differentiation (GO:0045628)2.51122883
117regulation of mast cell activation (GO:0033003)2.50876324
118regulation of natural killer cell mediated immunity (GO:0002715)2.50290226
119regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.50290226
120regulation of RIG-I signaling pathway (GO:0039535)2.49968180
121COPI coating of Golgi vesicle (GO:0048205)2.49895228
122Golgi transport vesicle coating (GO:0048200)2.49895228
123lymphocyte apoptotic process (GO:0070227)2.49412910
124interferon-gamma-mediated signaling pathway (GO:0060333)2.48907774
125respiratory burst (GO:0045730)2.48665858
126protein localization to endosome (GO:0036010)2.47536934
127antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.47461563
128G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.47242686
129dendritic cell differentiation (GO:0097028)2.46287293
130DNA strand elongation (GO:0022616)2.46022102
131regulation of necroptotic process (GO:0060544)2.45077406
132negative regulation of innate immune response (GO:0045824)2.44909198
133barbed-end actin filament capping (GO:0051016)2.44628366
134nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.44584451
135angiogenesis involved in wound healing (GO:0060055)2.44037610
136endosome to pigment granule transport (GO:0043485)2.43936844
137endosome to melanosome transport (GO:0035646)2.43936844
138regulation of defense response to virus by virus (GO:0050690)2.42725566
139regulation of B cell differentiation (GO:0045577)2.42519540
140translational initiation (GO:0006413)2.42375601
141positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.42144957
142regulation of regulated secretory pathway (GO:1903305)2.41288640
143lipoxygenase pathway (GO:0019372)2.39871476
144negative regulation of T cell mediated immunity (GO:0002710)2.38490604
145negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.38215307
146positive regulation of isotype switching (GO:0045830)2.38040568
147positive regulation of alpha-beta T cell proliferation (GO:0046641)2.36960123
148regulation of natural killer cell differentiation (GO:0032823)2.36938287
149telomere maintenance via recombination (GO:0000722)2.36062669
150positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.35947648
151leukocyte mediated cytotoxicity (GO:0001909)2.35136162
152cellular protein complex disassembly (GO:0043624)2.34852206
153regulation of type I interferon-mediated signaling pathway (GO:0060338)2.33897300
154positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.33320817
155formation of translation preinitiation complex (GO:0001731)2.32628351
156sequestering of actin monomers (GO:0042989)2.31812900
157definitive hemopoiesis (GO:0060216)2.31606841
158leukocyte aggregation (GO:0070486)2.31532459
159regulation of antigen processing and presentation (GO:0002577)2.31437586
160pinocytosis (GO:0006907)2.30011972
161lipopolysaccharide-mediated signaling pathway (GO:0031663)2.26080767
162regulation of necrotic cell death (GO:0010939)2.25561389
163regulation of alpha-beta T cell proliferation (GO:0046640)2.24613226
164natural killer cell differentiation (GO:0001779)2.23406875
165positive regulation of lamellipodium assembly (GO:0010592)2.22959630
166positive regulation of T-helper cell differentiation (GO:0045624)2.22724243
167positive regulation of interleukin-12 production (GO:0032735)2.21163214
168natural killer cell activation (GO:0030101)2.20738035
169regulation of hypersensitivity (GO:0002883)2.20278732
170leukocyte apoptotic process (GO:0071887)2.19177423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.16583034
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.02671403
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.29573217
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.25781595
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.92748062
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.91429532
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.72735665
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.72074648
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.57916679
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43201241
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.40868755
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.39170771
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.31062891
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.30403858
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29731559
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.25828633
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21170069
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10211289
19SPI1_23547873_ChIP-Seq_NB4_Human2.08634369
20VDR_21846776_ChIP-Seq_THP-1_Human2.06829280
21* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04250491
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.02770584
23IRF8_27001747_Chip-Seq_BMDM_Mouse1.99636289
24MYC_22102868_ChIP-Seq_BL_Human1.96609121
25SCL_19346495_ChIP-Seq_HPC-7_Human1.96057020
26* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94891946
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93323718
28* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92757138
29* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91941971
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.89275157
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86189800
32* LXR_22292898_ChIP-Seq_THP-1_Human1.85463906
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77516008
34* MYB_26560356_Chip-Seq_TH2_Human1.75818007
35* MAF_26560356_Chip-Seq_TH1_Human1.73689059
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73309919
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.70217208
38* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67099705
39VDR_24763502_ChIP-Seq_THP-1_Human1.66497125
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65551786
41* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64731013
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62682084
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.62151654
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61618284
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.61435601
46* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57799721
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56384873
48* RACK7_27058665_Chip-Seq_MCF-7_Human1.56117257
49* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.54265691
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.53639328
51* MYB_26560356_Chip-Seq_TH1_Human1.51518744
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50124151
53* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48183186
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43208264
55* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42982498
56* KDM2B_26808549_Chip-Seq_DND41_Human1.42195086
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40439632
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.39025576
59UTX_26944678_Chip-Seq_JUKART_Human1.38595408
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37972046
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.37967473
62* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37382900
63* NCOR1_26117541_ChIP-Seq_K562_Human1.36830347
64VDR_23849224_ChIP-Seq_CD4+_Human1.35809043
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35513626
66* ELK3_25401928_ChIP-Seq_HUVEC_Human1.34980519
67* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34207304
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31430373
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29889067
70* XRN2_22483619_ChIP-Seq_HELA_Human1.29621697
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28978076
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.27796407
73* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27664811
74* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27362348
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.27315035
76ELK1_19687146_ChIP-ChIP_HELA_Human1.25924698
77GATA1_19941826_ChIP-Seq_K562_Human1.25420827
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25082760
79* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24422267
80* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23619554
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22571380
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22042467
83DCP1A_22483619_ChIP-Seq_HELA_Human1.21629172
84* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19681001
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18603984
86CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17931272
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17500485
88BCL6_27268052_Chip-Seq_Bcells_Human1.16975639
89TCF7_22412390_ChIP-Seq_EML_Mouse1.16649878
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16622474
91BCOR_27268052_Chip-Seq_Bcells_Human1.16172920
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15866951
93* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15861070
94* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15746122
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15107320
96* E2F1_21310950_ChIP-Seq_MCF-7_Human1.14192288
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14044089
98* TFEB_21752829_ChIP-Seq_HELA_Human1.13057346
99GATA1_22025678_ChIP-Seq_K562_Human1.13042483
100* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12680739
101FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11454869
102SPI1_23127762_ChIP-Seq_K562_Human1.10057087
103SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09913357
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09744800
105ELF1_20517297_ChIP-Seq_JURKAT_Human1.09531449
106* MAF_26560356_Chip-Seq_TH2_Human1.08882168
107* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08363405
108SA1_27219007_Chip-Seq_ERYTHROID_Human1.08023215
109* FOXP3_21729870_ChIP-Seq_TREG_Human1.07373912
110STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06984370
111* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06751564
112FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06557745
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05212021
114AR_21909140_ChIP-Seq_LNCAP_Human1.05102413
115* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05036159
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04763657
117* ATF3_27146783_Chip-Seq_COLON_Human1.03757399
118* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03371719
119* PU_27001747_Chip-Seq_BMDM_Mouse1.03177717
120DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03123361
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02897201
122TET1_21451524_ChIP-Seq_MESCs_Mouse1.02659386
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01955295
124P68_20966046_ChIP-Seq_HELA_Human1.01442929
125* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00608853
126STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00562882
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00435740
128GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99960120
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99223626
130RUNX_20019798_ChIP-Seq_JUKART_Human0.98605707
131VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98565138
132SRF_21415370_ChIP-Seq_HL-1_Mouse0.98041437
133GABP_19822575_ChIP-Seq_HepG2_Human0.98006733
134ZNF263_19887448_ChIP-Seq_K562_Human0.97517800
135* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97481680
136Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96687346
137E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96120728
138CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95617647
139CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93165065
140TTF2_22483619_ChIP-Seq_HELA_Human0.92307430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.64238963
2MP0009785_altered_susceptibility_to3.08397040
3MP0000685_abnormal_immune_system2.92331622
4MP0003436_decreased_susceptibility_to2.90065667
5MP0002148_abnormal_hypersensitivity_rea2.72740684
6MP0003191_abnormal_cellular_cholesterol2.56742791
7MP0005671_abnormal_response_to2.54308565
8MP0002396_abnormal_hematopoietic_system2.47716815
9MP0005025_abnormal_response_to2.41120307
10MP0005000_abnormal_immune_tolerance2.40298628
11MP0001790_abnormal_immune_system2.28521018
12MP0005387_immune_system_phenotype2.28521018
13MP0003724_increased_susceptibility_to2.27764189
14MP0002419_abnormal_innate_immunity2.20364769
15MP0002452_abnormal_antigen_presenting2.16780953
16MP0001800_abnormal_humoral_immune2.10968656
17MP0002166_altered_tumor_susceptibility2.09504508
18MP0002723_abnormal_immune_serum2.05774362
19MP0008260_abnormal_autophagy2.04943461
20MP0001819_abnormal_immune_cell2.04173325
21MP0002420_abnormal_adaptive_immunity2.03801993
22MP0009333_abnormal_splenocyte_physiolog1.98054536
23MP0005397_hematopoietic_system_phenotyp1.94702391
24MP0001545_abnormal_hematopoietic_system1.94702391
25MP0003693_abnormal_embryo_hatching1.93053859
26MP0005464_abnormal_platelet_physiology1.91567896
27MP0004808_abnormal_hematopoietic_stem1.91282795
28MP0010352_gastrointestinal_tract_polyps1.88358999
29MP0001853_heart_inflammation1.88090966
30MP0002398_abnormal_bone_marrow1.85137924
31MP0005451_abnormal_body_composition1.84977028
32MP0003763_abnormal_thymus_physiology1.84018208
33MP0002006_tumorigenesis1.83958647
34MP0002405_respiratory_system_inflammati1.83398872
35MP0010155_abnormal_intestine_physiology1.81242804
36MP0003806_abnormal_nucleotide_metabolis1.76899406
37MP0000490_abnormal_crypts_of1.74927639
38MP0006054_spinal_hemorrhage1.73567463
39MP0000716_abnormal_immune_system1.69017860
40MP0003566_abnormal_cell_adhesion1.66993811
41MP0003303_peritoneal_inflammation1.65712606
42MP0000858_altered_metastatic_potential1.65118279
43MP0004947_skin_inflammation1.52906188
44MP0002877_abnormal_melanocyte_morpholog1.52694179
45MP0002722_abnormal_immune_system1.52597283
46MP0002429_abnormal_blood_cell1.52560089
47MP0001845_abnormal_inflammatory_respons1.52342799
48MP0001533_abnormal_skeleton_physiology1.51567709
49MP0000689_abnormal_spleen_morphology1.49920962
50MP0000465_gastrointestinal_hemorrhage1.44932331
51MP0006082_CNS_inflammation1.44193832
52MP0003300_gastrointestinal_ulcer1.36880015
53MP0003075_altered_response_to1.35429784
54MP0003448_altered_tumor_morphology1.35206385
55MP0001873_stomach_inflammation1.33820453
56MP0008007_abnormal_cellular_replicative1.30960077
57MP0000343_altered_response_to1.28708186
58MP0009278_abnormal_bone_marrow1.23683351
59MP0003866_abnormal_defecation1.23374995
60MP0009840_abnormal_foam_cell1.22544017
61MP0004957_abnormal_blastocyst_morpholog1.22462028
62MP0005023_abnormal_wound_healing1.20990262
63MP0003077_abnormal_cell_cycle1.19195866
64MP0008469_abnormal_protein_level1.16911584
65MP0010307_abnormal_tumor_latency1.16422063
66MP0005058_abnormal_lysosome_morphology1.13980779
67MP0003186_abnormal_redox_activity1.13372071
68MP0008438_abnormal_cutaneous_collagen1.13110383
69MP0010094_abnormal_chromosome_stability1.11556608
70MP0001348_abnormal_lacrimal_gland1.11322922
71MP0002019_abnormal_tumor_incidence1.10752339
72MP0000703_abnormal_thymus_morphology1.09995519
73MP0005164_abnormal_response_to1.08686727
74MP0004510_myositis1.06490079
75MP0003279_aneurysm1.06201065
76MP0005083_abnormal_biliary_tract1.06101073
77MP0005166_decreased_susceptibility_to1.04815140
78MP0008057_abnormal_DNA_replication1.04422220
79MP0004782_abnormal_surfactant_physiolog1.02337924
80MP0005174_abnormal_tail_pigmentation1.00616622
81MP0002163_abnormal_gland_morphology1.00048208
82MP0002933_joint_inflammation0.99857954
83MP0003183_abnormal_peptide_metabolism0.97464928
84MP0004883_abnormal_blood_vessel0.96892965
85MP0005165_increased_susceptibility_to0.96009142
86MP0001879_abnormal_lymphatic_vessel0.94499252
87MP0003656_abnormal_erythrocyte_physiolo0.94221296
88MP0002796_impaired_skin_barrier0.94037467
89MP0005076_abnormal_cell_differentiation0.93372797
90MP0003828_pulmonary_edema0.92930314
91MP0005310_abnormal_salivary_gland0.92278187
92MP0001849_ear_inflammation0.91561745
93MP0003111_abnormal_nucleus_morphology0.89563796
94MP0002132_abnormal_respiratory_system0.88979596
95MP0008004_abnormal_stomach_pH0.88667489
96MP0009764_decreased_sensitivity_to0.88465536
97MP0005501_abnormal_skin_physiology0.87841965
98MP0001958_emphysema0.86970831
99MP0003705_abnormal_hypodermis_morpholog0.86718144
100MP0005390_skeleton_phenotype0.84217352
101MP0000249_abnormal_blood_vessel0.82267237
102MP0003795_abnormal_bone_structure0.81549957
103MP0003172_abnormal_lysosome_physiology0.80655585
104MP0003091_abnormal_cell_migration0.80471303
105MP0010368_abnormal_lymphatic_system0.80144106
106MP0000313_abnormal_cell_death0.80057708
107MP0001663_abnormal_digestive_system0.78811651
108MP0002998_abnormal_bone_remodeling0.78130182
109MP0002060_abnormal_skin_morphology0.77817765
110MP0004381_abnormal_hair_follicle0.76863088
111MP0002138_abnormal_hepatobiliary_system0.76115554
112MP0001216_abnormal_epidermal_layer0.75962319
113MP0001915_intracranial_hemorrhage0.74227597
114MP0003045_fibrosis0.72170063
115MP0001851_eye_inflammation0.71747120
116MP0008874_decreased_physiological_sensi0.71665259
117MP0009931_abnormal_skin_appearance0.70921106
118MP0010234_abnormal_vibrissa_follicle0.70657028
119MP0008058_abnormal_DNA_repair0.69529868
120MP0000350_abnormal_cell_proliferation0.69457456
121MP0003943_abnormal_hepatobiliary_system0.69424929
122MP0005621_abnormal_cell_physiology0.68904562
123MP0009763_increased_sensitivity_to0.67354118
124MP0003453_abnormal_keratinocyte_physiol0.65659208
125MP0005275_abnormal_skin_tensile0.63374586
126MP0000477_abnormal_intestine_morphology0.62345105

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.64096623
2Elevated erythrocyte sedimentation rate (HP:0003565)4.57966793
3Thrombocytosis (HP:0001894)4.33581410
4Eczematoid dermatitis (HP:0000976)4.20247363
5Myositis (HP:0100614)4.11980179
6Recurrent bacterial skin infections (HP:0005406)4.10744766
7Chronic otitis media (HP:0000389)3.97208655
8Interstitial pulmonary disease (HP:0006530)3.66461030
9Petechiae (HP:0000967)3.65213062
10Menorrhagia (HP:0000132)3.57235474
11Autoimmune thrombocytopenia (HP:0001973)3.44656047
12Abnormality of macrophages (HP:0004311)3.21698266
13Orchitis (HP:0100796)3.10921348
14Abnormality of cells of the erythroid lineage (HP:0012130)3.05752477
15IgM deficiency (HP:0002850)3.03781531
16Recurrent viral infections (HP:0004429)3.00649131
17Recurrent fungal infections (HP:0002841)2.99778302
18Abnormal number of erythroid precursors (HP:0012131)2.99420114
19Reticulocytopenia (HP:0001896)2.94658909
20Stomatitis (HP:0010280)2.91732745
21Cellulitis (HP:0100658)2.89245324
22Abnormality of T cell physiology (HP:0011840)2.86029055
23Abnormality of the nasal mucosa (HP:0000433)2.85038377
24Aplastic anemia (HP:0001915)2.83471125
25Vacuolated lymphocytes (HP:0001922)2.75064896
26Hepatosplenomegaly (HP:0001433)2.74158492
27Nasal polyposis (HP:0100582)2.72122275
28Mediastinal lymphadenopathy (HP:0100721)2.70666446
29Recurrent bronchitis (HP:0002837)2.65422479
30Vasculitis (HP:0002633)2.63397446
31Recurrent gram-negative bacterial infections (HP:0005420)2.59126827
32Chronic obstructive pulmonary disease (HP:0006510)2.57697138
33Obstructive lung disease (HP:0006536)2.57697138
34Optic neuritis (HP:0100653)2.56677752
35Retrobulbar optic neuritis (HP:0100654)2.56677752
36Vertebral compression fractures (HP:0002953)2.56195863
37Recurrent skin infections (HP:0001581)2.54794971
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.54303046
39Hypergammaglobulinemia (HP:0010702)2.53677889
40Pustule (HP:0200039)2.49910389
41Hypertensive crisis (HP:0100735)2.47131652
42Abnormality of T cells (HP:0002843)2.44150783
43Increased IgM level (HP:0003496)2.43392507
44Encephalitis (HP:0002383)2.41006591
45Basal ganglia calcification (HP:0002135)2.40912079
46Periodontitis (HP:0000704)2.39723974
47Prolonged bleeding time (HP:0003010)2.39701494
48Amyloidosis (HP:0011034)2.38763183
49Spontaneous hematomas (HP:0007420)2.38352924
50Increased serum ferritin (HP:0003281)2.37815753
51Distal lower limb muscle weakness (HP:0009053)2.37466107
52Osteolytic defects of the hand bones (HP:0009699)2.34193318
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.34193318
54Distal lower limb amyotrophy (HP:0008944)2.29642777
55Meningitis (HP:0001287)2.29632306
56Leukocytosis (HP:0001974)2.28435464
57Epistaxis (HP:0000421)2.26680463
58Poor head control (HP:0002421)2.20806912
59Dysostosis multiplex (HP:0000943)2.20464114
60Episodic fever (HP:0001954)2.19792519
61Skin ulcer (HP:0200042)2.18685425
62Polycythemia (HP:0001901)2.18481895
63Arterial thrombosis (HP:0004420)2.18122029
64Osteomyelitis (HP:0002754)2.14990058
65Abnormality of liposaccharide metabolism (HP:0010968)2.14268573
66Abnormality of glycosphingolipid metabolism (HP:0004343)2.14268573
67Abnormality of glycolipid metabolism (HP:0010969)2.14268573
68Abnormal platelet volume (HP:0011876)2.13757650
69Cervical subluxation (HP:0003308)2.12898241
70Pulmonary infiltrates (HP:0002113)2.12023845
71Granulocytopenia (HP:0001913)2.11849419
72Eosinophilia (HP:0001880)2.11056425
73Purpura (HP:0000979)2.10645874
74Abnormality of iron homeostasis (HP:0011031)2.10435365
75Abnormal platelet function (HP:0011869)2.09981838
76Impaired platelet aggregation (HP:0003540)2.09981838
77Reduced antithrombin III activity (HP:0001976)2.09908429
78Increased IgE level (HP:0003212)2.08574564
79Pallor (HP:0000980)2.08072624
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.07872954
81Hemoptysis (HP:0002105)2.07208573
82Gingivitis (HP:0000230)2.06506312
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.06335162
84Bruising susceptibility (HP:0000978)2.05459590
85Amaurosis fugax (HP:0100576)2.04446909
86Broad face (HP:0000283)2.04213707
87Fatigue (HP:0012378)2.02257107
88Abnormality of T cell number (HP:0011839)1.98500268
89Premature rupture of membranes (HP:0001788)1.98279532
90Increased cerebral lipofuscin (HP:0011813)1.97570659
91Chest pain (HP:0100749)1.97215540
92Urticaria (HP:0001025)1.96186849
93Hypertriglyceridemia (HP:0002155)1.95293737
94Colitis (HP:0002583)1.95085094
95Autoimmune hemolytic anemia (HP:0001890)1.94725348
9611 pairs of ribs (HP:0000878)1.93040401
97Lymphopenia (HP:0001888)1.92996428
98IgA deficiency (HP:0002720)1.92348624
99Loss of speech (HP:0002371)1.92066018
100Abnormality of the prostate (HP:0008775)1.91491990
101Hematochezia (HP:0002573)1.90902604
102Peritonitis (HP:0002586)1.90526055
103Beaking of vertebral bodies (HP:0004568)1.89877984
104Chronic mucocutaneous candidiasis (HP:0002728)1.89533733
105Recurrent cutaneous fungal infections (HP:0011370)1.89533733
106Acute myeloid leukemia (HP:0004808)1.88876573
107Increased mean platelet volume (HP:0011877)1.88821649
108Glomerulopathy (HP:0100820)1.88527099
109Increased connective tissue (HP:0009025)1.88026981
110Polygenic inheritance (HP:0010982)1.87089131
111IgG deficiency (HP:0004315)1.86601786
112Gastrointestinal infarctions (HP:0005244)1.86211502
113Dilatation of the ascending aorta (HP:0005111)1.85188467
114Abnormality of eosinophils (HP:0001879)1.84658444
115Skin rash (HP:0000988)1.84161607
116Lymphoma (HP:0002665)1.82159013
117Gingival bleeding (HP:0000225)1.81916097
118Gastrointestinal dysmotility (HP:0002579)1.81836853
119Gastrointestinal stroma tumor (HP:0100723)1.81271948
120Type I transferrin isoform profile (HP:0003642)1.80583464
121Agammaglobulinemia (HP:0004432)1.79285149
122Abnormality of the distal phalanges of the toes (HP:0010182)1.78438117
123Increased density of long bones (HP:0006392)1.77133544
124Keratoconjunctivitis sicca (HP:0001097)1.75725632
125Gastrointestinal inflammation (HP:0004386)1.75218406
126Panhypogammaglobulinemia (HP:0003139)1.74893440
127Myocardial infarction (HP:0001658)1.74791487
128Protrusio acetabuli (HP:0003179)1.73412727
129Abnormality of the pericardium (HP:0001697)1.73364861
130Abnormality of the heme biosynthetic pathway (HP:0010472)1.73047051
131Anorexia (HP:0002039)1.70782809
132Recurrent lower respiratory tract infections (HP:0002783)1.69864747
133Recurrent pneumonia (HP:0006532)1.69704162
134Inflammation of the large intestine (HP:0002037)1.69636756
135Cholecystitis (HP:0001082)1.69243074
136Abnormal gallbladder physiology (HP:0012438)1.69243074
137Keratoconjunctivitis (HP:0001096)1.69125749
138Reduced subcutaneous adipose tissue (HP:0003758)1.68270299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIM23.00455465
2MAP4K12.91838180
3NME22.74868122
4MAP3K142.50860964
5PRPF4B2.45547358
6TBK12.42263704
7JAK32.31666953
8BLK2.15650746
9TYK22.09767479
10KIT2.05473191
11SMG12.02770381
12IRAK42.01313153
13ERN11.93359410
14TESK11.87919176
15RPS6KA41.85132148
16BTK1.85066444
17ZAP701.78703309
18LRRK21.77783581
19TEC1.77220521
20STK101.74721362
21KDR1.70709253
22TGFBR11.67733680
23ACVR1B1.65531385
24IKBKB1.62718800
25MAP2K31.61474310
26FES1.59199726
27FLT31.57433546
28TAOK21.53931306
29IKBKE1.53242115
30TXK1.51070172
31WEE11.46031698
32SCYL21.45070234
33TESK21.39227048
34RPS6KB21.38514652
35EEF2K1.37325563
36TRIB31.35115793
37MST1R1.26728948
38SIK11.26671452
39PIM11.23231767
40PKN21.22808922
41MAP3K11.20726285
42PAK41.19956873
43MST41.19896427
44NEK91.19325732
45IRAK31.12840639
46TIE11.12487049
47TAOK11.12425554
48BRSK21.12295854
49EIF2AK31.12142815
50TNK21.11918455
51EIF2AK11.11358640
52CSF1R1.10625963
53MAP3K131.09768614
54MAP3K111.09761953
55ARAF1.09150373
56SYK1.09026704
57TGFBR21.07167314
58STK161.06999537
59BUB11.03033062
60EPHA21.00764560
61CHUK0.98908520
62TRPM70.96302239
63MAP3K30.95204590
64JAK10.94623590
65MATK0.91614245
66EPHB10.90391882
67KSR20.88599499
68MAPKAPK30.88029670
69TTN0.87586394
70LMTK20.87502681
71FGR0.85701513
72MAP3K80.83800641
73ILK0.83385001
74BMPR20.82598553
75CDC70.82181978
76LCK0.81809936
77JAK20.78680533
78ITK0.78000886
79HCK0.77887156
80PRKD20.77830703
81NEK20.77801021
82TAOK30.77457764
83PRKG20.76977632
84PTK2B0.75953257
85MAPKAPK20.75485023
86NLK0.73487515
87VRK10.71887537
88PDPK10.71411035
89LYN0.71294449
90MAP3K60.69626780
91STK40.69353137
92LIMK10.68803626
93CSK0.67694523
94CDK60.67074237
95CDK70.66979529
96MAP3K120.65798386
97HIPK20.65427530
98IRAK10.65112997
99PTK60.64925326
100PASK0.64226239
101IRAK20.61544271
102CDK40.61419945
103ABL20.60612264
104EIF2AK20.60036362
105MAP3K20.59923564
106MYLK0.59070431
107MOS0.58656774
108RAF10.56931982
109VRK20.55809795
110CDC42BPA0.55384121
111PDK10.54478991
112PTK20.53818990
113AURKB0.52522610
114TSSK60.51947378
115YES10.49998936
116RIPK10.49842650
117RPS6KA60.49215574
118MAPK110.48921908
119DAPK10.47586279
120ATR0.46967380
121STK240.46578731
122BMX0.45991124
123PIK3CG0.45609800
124RIPK40.44774116
125SIK30.44761147
126FGFR40.44453018
127MAP2K20.43880620
128PAK10.43465964
129GRK60.42653323
130MARK20.41756231
131CLK10.41374502
132STK380.39870480
133PRKCD0.39598705
134MAPK120.39278912
135MARK30.38195778
136MAP3K100.37994457

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.82953211
2Ribosome_Homo sapiens_hsa030102.55061063
3Allograft rejection_Homo sapiens_hsa053302.39555869
4Leishmaniasis_Homo sapiens_hsa051402.38864481
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.35545325
6Proteasome_Homo sapiens_hsa030502.14827062
7Graft-versus-host disease_Homo sapiens_hsa053322.08949391
8Antigen processing and presentation_Homo sapiens_hsa046121.95021920
9Legionellosis_Homo sapiens_hsa051341.92868311
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.89721473
11Measles_Homo sapiens_hsa051621.87626164
12Mismatch repair_Homo sapiens_hsa034301.84376246
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.82834022
14Base excision repair_Homo sapiens_hsa034101.75256362
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75248309
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.73043873
17Shigellosis_Homo sapiens_hsa051311.69427859
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66054625
19Herpes simplex infection_Homo sapiens_hsa051681.63478612
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63197605
21Primary immunodeficiency_Homo sapiens_hsa053401.62892829
22Pertussis_Homo sapiens_hsa051331.57767809
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52379140
24Apoptosis_Homo sapiens_hsa042101.47056847
25Hematopoietic cell lineage_Homo sapiens_hsa046401.44836571
26Toxoplasmosis_Homo sapiens_hsa051451.43447909
27Osteoclast differentiation_Homo sapiens_hsa043801.43287594
28Malaria_Homo sapiens_hsa051441.43016673
29Influenza A_Homo sapiens_hsa051641.41172207
30Viral myocarditis_Homo sapiens_hsa054161.39221085
31TNF signaling pathway_Homo sapiens_hsa046681.33957578
32p53 signaling pathway_Homo sapiens_hsa041151.31953536
33Homologous recombination_Homo sapiens_hsa034401.30165911
34Non-small cell lung cancer_Homo sapiens_hsa052231.29728237
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.28411217
36Salmonella infection_Homo sapiens_hsa051321.25341638
37B cell receptor signaling pathway_Homo sapiens_hsa046621.25068469
38Autoimmune thyroid disease_Homo sapiens_hsa053201.24122104
39Type I diabetes mellitus_Homo sapiens_hsa049401.22848754
40Other glycan degradation_Homo sapiens_hsa005111.20188908
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19979129
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.19528753
43Asthma_Homo sapiens_hsa053101.15974645
44Nucleotide excision repair_Homo sapiens_hsa034201.15828586
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14503975
46Tuberculosis_Homo sapiens_hsa051521.14059181
47Hepatitis B_Homo sapiens_hsa051611.13919108
48Endocytosis_Homo sapiens_hsa041441.12119027
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11938891
50Pyrimidine metabolism_Homo sapiens_hsa002401.09608752
51Cell cycle_Homo sapiens_hsa041101.06013730
52Acute myeloid leukemia_Homo sapiens_hsa052211.05663508
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05538396
54Epstein-Barr virus infection_Homo sapiens_hsa051691.04249650
55Spliceosome_Homo sapiens_hsa030401.03964744
56Bladder cancer_Homo sapiens_hsa052191.01909109
57One carbon pool by folate_Homo sapiens_hsa006701.01865110
58Small cell lung cancer_Homo sapiens_hsa052221.01807855
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99348013
60VEGF signaling pathway_Homo sapiens_hsa043700.98030703
61Rheumatoid arthritis_Homo sapiens_hsa053230.90821699
62Chronic myeloid leukemia_Homo sapiens_hsa052200.90509399
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88455160
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88352659
65Viral carcinogenesis_Homo sapiens_hsa052030.87333748
66Platelet activation_Homo sapiens_hsa046110.87310625
67Lysosome_Homo sapiens_hsa041420.85595679
68RNA polymerase_Homo sapiens_hsa030200.85216077
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85104003
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84827066
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83560309
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83381078
73Thyroid cancer_Homo sapiens_hsa052160.81596047
74HTLV-I infection_Homo sapiens_hsa051660.81418466
75Protein export_Homo sapiens_hsa030600.81241283
76Renal cell carcinoma_Homo sapiens_hsa052110.81030374
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.80179911
78Chemokine signaling pathway_Homo sapiens_hsa040620.79650695
79RNA transport_Homo sapiens_hsa030130.78566822
80Phagosome_Homo sapiens_hsa041450.77783471
81Fructose and mannose metabolism_Homo sapiens_hsa000510.74373327
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73575040
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72787468
84Hepatitis C_Homo sapiens_hsa051600.72665836
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71758237
86Notch signaling pathway_Homo sapiens_hsa043300.70966552
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69390421
88Pentose phosphate pathway_Homo sapiens_hsa000300.66493952
89Amoebiasis_Homo sapiens_hsa051460.66051748
90Non-homologous end-joining_Homo sapiens_hsa034500.66023930
91Staphylococcus aureus infection_Homo sapiens_hsa051500.65818111
92T cell receptor signaling pathway_Homo sapiens_hsa046600.65099307
93N-Glycan biosynthesis_Homo sapiens_hsa005100.64515389
94African trypanosomiasis_Homo sapiens_hsa051430.63324648
95Pancreatic cancer_Homo sapiens_hsa052120.62780494
96RNA degradation_Homo sapiens_hsa030180.57397066
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56840047
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.56677792
99Endometrial cancer_Homo sapiens_hsa052130.54976313
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.52233875
101Renin-angiotensin system_Homo sapiens_hsa046140.51620949
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.50559231
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50496729
104HIF-1 signaling pathway_Homo sapiens_hsa040660.50002681
105Vibrio cholerae infection_Homo sapiens_hsa051100.48348685
106Fanconi anemia pathway_Homo sapiens_hsa034600.48334712
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47652751
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.46087026
109Proteoglycans in cancer_Homo sapiens_hsa052050.45813142
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.44564453
111Focal adhesion_Homo sapiens_hsa045100.44544455
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43673479
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42007420
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.41559414
115Galactose metabolism_Homo sapiens_hsa000520.40324985
116MicroRNAs in cancer_Homo sapiens_hsa052060.39468743
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38565739
118Adherens junction_Homo sapiens_hsa045200.38481324
119Prolactin signaling pathway_Homo sapiens_hsa049170.38189533
120Colorectal cancer_Homo sapiens_hsa052100.37379943
121Arachidonic acid metabolism_Homo sapiens_hsa005900.35308127
122Systemic lupus erythematosus_Homo sapiens_hsa053220.33997350
123ECM-receptor interaction_Homo sapiens_hsa045120.33779223
124Choline metabolism in cancer_Homo sapiens_hsa052310.32660058

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