TAGLN2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.83706079
2Arp2/3 complex-mediated actin nucleation (GO:0034314)4.79654797
3DNA deamination (GO:0045006)4.52926029
4cytidine metabolic process (GO:0046087)4.38060624
5cytidine catabolic process (GO:0006216)4.38060624
6cytidine deamination (GO:0009972)4.38060624
7positive regulation of gamma-delta T cell activation (GO:0046645)4.27212149
8regulation of B cell receptor signaling pathway (GO:0050855)4.23900740
9positive regulation of granulocyte differentiation (GO:0030854)4.21466878
10negative regulation of T cell apoptotic process (GO:0070233)4.20942494
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.19138075
12actin nucleation (GO:0045010)4.17883727
13positive regulation of natural killer cell mediated immunity (GO:0002717)4.17125619
14regulation of regulatory T cell differentiation (GO:0045589)4.03028829
15positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.98043754
16regulation of natural killer cell mediated immunity (GO:0002715)3.83174472
17regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.83174472
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.79329292
19positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.71422127
20pyrimidine ribonucleoside catabolic process (GO:0046133)3.70647493
21positive regulation of T cell mediated cytotoxicity (GO:0001916)3.67735503
22positive regulation of B cell differentiation (GO:0045579)3.65766209
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.62606189
24regulation of T cell mediated cytotoxicity (GO:0001914)3.55680726
25regulation of leukocyte mediated cytotoxicity (GO:0001910)3.53374705
26neutrophil activation involved in immune response (GO:0002283)3.45721912
27thrombin receptor signaling pathway (GO:0070493)3.43647590
28negative regulation of stress fiber assembly (GO:0051497)3.37989260
29antigen processing and presentation of endogenous antigen (GO:0019883)3.35176762
30positive thymic T cell selection (GO:0045059)3.33435458
31negative regulation of cell killing (GO:0031342)3.23363922
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.23363922
33positive regulation of cell killing (GO:0031343)3.21771963
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.20504952
35regulation of gamma-delta T cell differentiation (GO:0045586)3.19039793
36positive regulation of tolerance induction (GO:0002645)3.14591250
37regulation of cell killing (GO:0031341)3.12720189
38positive regulation of alpha-beta T cell proliferation (GO:0046641)3.12608637
39negative regulation of interleukin-12 production (GO:0032695)3.12556041
40regulation of T cell apoptotic process (GO:0070232)3.12434683
41negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.10987300
42negative regulation of T-helper cell differentiation (GO:0045623)3.10987300
43G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.10840401
44negative regulation of lymphocyte apoptotic process (GO:0070229)3.06043985
45cellular response to interleukin-15 (GO:0071350)3.06005384
46regulation of B cell differentiation (GO:0045577)3.04516529
47regulation of alpha-beta T cell proliferation (GO:0046640)3.01116008
48negative regulation of nitric oxide biosynthetic process (GO:0045019)3.00803675
49mast cell activation (GO:0045576)3.00145500
50positive T cell selection (GO:0043368)2.99516427
51negative T cell selection (GO:0043383)2.98675547
52regulation of gamma-delta T cell activation (GO:0046643)2.97351044
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.94345031
54regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.89325344
55response to interleukin-15 (GO:0070672)2.88775504
56positive regulation of interleukin-10 production (GO:0032733)2.88140665
57protein neddylation (GO:0045116)2.87627597
58negative thymic T cell selection (GO:0045060)2.87531333
59immunoglobulin mediated immune response (GO:0016064)2.86299081
60purinergic nucleotide receptor signaling pathway (GO:0035590)2.85877700
61pyrimidine nucleoside catabolic process (GO:0046135)2.84956415
62negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.84182441
63regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.83920167
64B cell mediated immunity (GO:0019724)2.83197625
65negative regulation of thymocyte apoptotic process (GO:0070244)2.81748200
66defense response to protozoan (GO:0042832)2.80573763
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.80138092
68positive regulation of interleukin-17 production (GO:0032740)2.79418227
69negative regulation of actin filament bundle assembly (GO:0032232)2.79339595
70antigen receptor-mediated signaling pathway (GO:0050851)2.78616217
71neutrophil activation (GO:0042119)2.75773233
72regulation of chronic inflammatory response (GO:0002676)2.75525162
73regulation of interleukin-17 production (GO:0032660)2.75064753
74positive regulation of T cell mediated immunity (GO:0002711)2.72677453
75response to interferon-beta (GO:0035456)2.71780196
76regulation of granulocyte differentiation (GO:0030852)2.70572985
77interferon-gamma production (GO:0032609)2.68101436
78T cell receptor signaling pathway (GO:0050852)2.66819717
79cytolysis (GO:0019835)2.65656746
80T cell migration (GO:0072678)2.65525746
81positive regulation of lymphocyte mediated immunity (GO:0002708)2.65161205
82negative regulation of interleukin-17 production (GO:0032700)2.62939320
83regulation of T cell tolerance induction (GO:0002664)2.62687298
84NIK/NF-kappaB signaling (GO:0038061)2.62590711
85regulation of tolerance induction (GO:0002643)2.61605073
86positive regulation of interleukin-4 production (GO:0032753)2.61454069
87positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.60001081
88myeloid dendritic cell activation (GO:0001773)2.59557900
89antigen processing and presentation via MHC class Ib (GO:0002475)2.59307344
90regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.59294641
91regulation of T cell receptor signaling pathway (GO:0050856)2.58268990
92B cell receptor signaling pathway (GO:0050853)2.58166696
93positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.57327027
94lymphocyte costimulation (GO:0031294)2.55307582
95regulation of T cell mediated immunity (GO:0002709)2.55013920
96regulation of lymphocyte apoptotic process (GO:0070228)2.53995675
97positive regulation of interleukin-1 beta secretion (GO:0050718)2.53553187
98mature B cell differentiation involved in immune response (GO:0002313)2.53227485
99purine nucleotide salvage (GO:0032261)2.51978325
100positive regulation of isotype switching (GO:0045830)2.51678527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.92958698
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.31990189
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.26177311
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.17125350
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.04081794
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.00067883
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.28684233
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.24325012
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.19322394
10MYB_26560356_Chip-Seq_TH2_Human2.88822298
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.88526831
12LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.72072059
13SCL_19346495_ChIP-Seq_HPC-7_Human2.70340364
14RUNX_20019798_ChIP-Seq_JUKART_Human2.68234369
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.63430671
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.29757987
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.26606196
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14681119
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.13622534
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10740073
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.97327849
22MYB_26560356_Chip-Seq_TH1_Human1.96926737
23GATA3_27048872_Chip-Seq_THYMUS_Human1.95610245
24GATA3_26560356_Chip-Seq_TH2_Human1.93828427
25SPI1_23547873_ChIP-Seq_NB4_Human1.89218851
26LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.85818944
27GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.84735396
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.75421652
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72275578
30UTX_26944678_Chip-Seq_JUKART_Human1.70959271
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68816895
32VDR_23849224_ChIP-Seq_CD4+_Human1.68703349
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66566969
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61885418
35SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60063797
36MAF_26560356_Chip-Seq_TH1_Human1.56598668
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53004464
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47593660
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44877017
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42738767
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.42518208
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39827500
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.39651932
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.39501474
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.33087131
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28900809
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28638255
48SPI1_23127762_ChIP-Seq_K562_Human1.28079157
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27634637
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.27382554
51BCL6_27268052_Chip-Seq_Bcells_Human1.24520089
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23780085
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22352209
54FOXP3_21729870_ChIP-Seq_TREG_Human1.17688203
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17428513
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15891474
57HTT_18923047_ChIP-ChIP_STHdh_Human1.15332459
58FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13717126
59VDR_22108803_ChIP-Seq_LS180_Human1.12840222
60MAF_26560356_Chip-Seq_TH2_Human1.12566240
61CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12218803
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11645550
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11189543
64GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09660910
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09374858
66SPI1_20517297_ChIP-Seq_HL60_Human1.08186572
67TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07007945
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04233223
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04117201
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.03720123
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.03081436
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02523578
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01818106
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00193327
75AR_20517297_ChIP-Seq_VCAP_Human0.99453232
76PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98196843
77TP53_22573176_ChIP-Seq_HFKS_Human0.97444322
78GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97261470
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95470771
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93495345
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92707837
82GATA1_22025678_ChIP-Seq_K562_Human0.91797932
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91322108
84P300_27268052_Chip-Seq_Bcells_Human0.91309862
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91077525
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90374674
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89343274
88GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88575986
89NANOG_20526341_ChIP-Seq_ESCs_Human0.88133833
90GATA3_26560356_Chip-Seq_TH1_Human0.87884725
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.86750186
92VDR_24787735_ChIP-Seq_THP-1_Human0.86303879
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.85226402
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85140573
95VDR_24763502_ChIP-Seq_THP-1_Human0.85115979
96TAF2_19829295_ChIP-Seq_ESCs_Human0.84973368
97GATA1_19941826_ChIP-Seq_K562_Human0.84181945
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.83843611
99GATA1_19941827_ChIP-Seq_MEL_Mouse0.83760875
100CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82445997

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.19416816
2MP0005671_abnormal_response_to4.11941521
3MP0005464_abnormal_platelet_physiology3.89911125
4MP0003724_increased_susceptibility_to3.33507587
5MP0009785_altered_susceptibility_to3.13403357
6MP0005000_abnormal_immune_tolerance2.91855734
7MP0003763_abnormal_thymus_physiology2.84530559
8MP0002148_abnormal_hypersensitivity_rea2.76360027
9MP0001800_abnormal_humoral_immune2.74210572
10MP0005387_immune_system_phenotype2.54218912
11MP0001790_abnormal_immune_system2.54218912
12MP0002723_abnormal_immune_serum2.50718549
13MP0003806_abnormal_nucleotide_metabolis2.49407630
14MP0000685_abnormal_immune_system2.43909298
15MP0009333_abnormal_splenocyte_physiolog2.42038605
16MP0003436_decreased_susceptibility_to2.35260154
17MP0005025_abnormal_response_to2.33406396
18MP0002420_abnormal_adaptive_immunity2.32983194
19MP0002166_altered_tumor_susceptibility2.30389821
20MP0001819_abnormal_immune_cell2.29461482
21MP0002452_abnormal_antigen_presenting2.29361055
22MP0003866_abnormal_defecation2.06262929
23MP0010155_abnormal_intestine_physiology2.00284344
24MP0002398_abnormal_bone_marrow1.95513810
25MP0002419_abnormal_innate_immunity1.88727123
26MP0002006_tumorigenesis1.83164853
27MP0001873_stomach_inflammation1.81890764
28MP0000716_abnormal_immune_system1.81679913
29MP0008004_abnormal_stomach_pH1.66339170
30MP0000689_abnormal_spleen_morphology1.64072901
31MP0001845_abnormal_inflammatory_respons1.63607524
32MP0002722_abnormal_immune_system1.57570662
33MP0002429_abnormal_blood_cell1.56054546
34MP0006082_CNS_inflammation1.55238106
35MP0009764_decreased_sensitivity_to1.55169991
36MP0001533_abnormal_skeleton_physiology1.53590187
37MP0008872_abnormal_physiological_respon1.51489340
38MP0002405_respiratory_system_inflammati1.49056942
39MP0008875_abnormal_xenobiotic_pharmacok1.43532069
40MP0004947_skin_inflammation1.42548224
41MP0000703_abnormal_thymus_morphology1.38088622
42MP0003303_peritoneal_inflammation1.37844907
43MP0003183_abnormal_peptide_metabolism1.29190747
44MP0005075_abnormal_melanosome_morpholog1.28683321
45MP0002933_joint_inflammation1.26798712
46MP0003045_fibrosis1.26217907
47MP0005646_abnormal_pituitary_gland1.23179951
48MP0003448_altered_tumor_morphology1.20599269
49MP0008469_abnormal_protein_level1.18895360
50MP0000465_gastrointestinal_hemorrhage1.18368074
51MP0009763_increased_sensitivity_to1.10749711
52MP0005084_abnormal_gallbladder_morpholo1.10221801
53MP0005310_abnormal_salivary_gland1.09462800
54MP0005451_abnormal_body_composition1.09161780
55MP0003646_muscle_fatigue1.08392404
56MP0002277_abnormal_respiratory_mucosa1.07193253
57MP0000372_irregular_coat_pigmentation1.04020632
58MP0004381_abnormal_hair_follicle1.02076962
59MP0000343_altered_response_to1.00078374
60MP0004147_increased_porphyrin_level0.99339007
61MP0005167_abnormal_blood-brain_barrier0.99099699
62MP0001663_abnormal_digestive_system0.98540024
63MP0003300_gastrointestinal_ulcer0.96931861
64MP0002163_abnormal_gland_morphology0.96063649
65MP0000858_altered_metastatic_potential0.94844790
66MP0005166_decreased_susceptibility_to0.92294677
67MP0002396_abnormal_hematopoietic_system0.92118209
68MP0001545_abnormal_hematopoietic_system0.91071367
69MP0005397_hematopoietic_system_phenotyp0.91071367
70MP0005083_abnormal_biliary_tract0.89655182
71MP0005379_endocrine/exocrine_gland_phen0.89321527
72MP0005410_abnormal_fertilization0.88053625
73MP0002019_abnormal_tumor_incidence0.86014500
74MP0009278_abnormal_bone_marrow0.85841914
75MP0002138_abnormal_hepatobiliary_system0.83197269
76MP0002102_abnormal_ear_morphology0.82809962
77MP0008873_increased_physiological_sensi0.81196681
78MP0009765_abnormal_xenobiotic_induced0.80247443
79MP0001968_abnormal_touch/_nociception0.80161149
80MP0000230_abnormal_systemic_arterial0.76259939
81MP0004808_abnormal_hematopoietic_stem0.73275194
82MP0000249_abnormal_blood_vessel0.73171969
83MP0003638_abnormal_response/metabolism_0.72713607
84MP0001905_abnormal_dopamine_level0.72392920
85MP0001853_heart_inflammation0.70891369
86MP0003191_abnormal_cellular_cholesterol0.70658944
87MP0004484_altered_response_of0.67098192
88MP0003075_altered_response_to0.66452389
89MP0005584_abnormal_enzyme/coenzyme_acti0.65971247
90MP0005390_skeleton_phenotype0.65486800
91MP0003878_abnormal_ear_physiology0.65233391
92MP0005377_hearing/vestibular/ear_phenot0.65233391
93MP0006072_abnormal_retinal_apoptosis0.64450708
94MP0000490_abnormal_crypts_of0.62090137
95MP0004142_abnormal_muscle_tone0.61876102
96MP0005165_increased_susceptibility_to0.61836577
97MP0001919_abnormal_reproductive_system0.61013063
98MP0001765_abnormal_ion_homeostasis0.59912691
99MP0005645_abnormal_hypothalamus_physiol0.59819773
100MP0003656_abnormal_erythrocyte_physiolo0.59393455

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.10601000
2Elevated erythrocyte sedimentation rate (HP:0003565)4.96147697
3Prolonged bleeding time (HP:0003010)4.95060725
4Aplastic anemia (HP:0001915)4.65607038
5IgG deficiency (HP:0004315)4.21078272
6Increased IgM level (HP:0003496)4.18061413
7Petechiae (HP:0000967)4.08599093
8Epistaxis (HP:0000421)3.61584539
9Hypoproteinemia (HP:0003075)3.52035253
10Increased hepatocellular lipid droplets (HP:0006565)3.38102184
11Encephalitis (HP:0002383)3.36798660
12T lymphocytopenia (HP:0005403)3.36381996
13Purpura (HP:0000979)3.32506646
14Myositis (HP:0100614)3.32114859
15Menorrhagia (HP:0000132)3.31637834
16Exertional dyspnea (HP:0002875)3.30944648
17Abnormality of T cell number (HP:0011839)3.26344337
183-Methylglutaconic aciduria (HP:0003535)3.23429014
19Increased intramyocellular lipid droplets (HP:0012240)3.21250896
20Abnormality of T cells (HP:0002843)3.07412869
21Optic neuritis (HP:0100653)3.06126845
22Retrobulbar optic neuritis (HP:0100654)3.06126845
23Lipid accumulation in hepatocytes (HP:0006561)3.02935084
24Absent rod-and cone-mediated responses on ERG (HP:0007688)3.01448927
25Abnormal platelet volume (HP:0011876)2.99242633
26Mitochondrial inheritance (HP:0001427)2.91456724
27Abnormal delayed hypersensitivity skin test (HP:0002963)2.87958933
28Renal Fanconi syndrome (HP:0001994)2.87887095
29Increased mean platelet volume (HP:0011877)2.86195175
30Gingival bleeding (HP:0000225)2.85813592
31Recurrent cutaneous fungal infections (HP:0011370)2.85538841
32Chronic mucocutaneous candidiasis (HP:0002728)2.85538841
33Abnormality of T cell physiology (HP:0011840)2.80606337
34Orchitis (HP:0100796)2.80305834
35Recurrent fungal infections (HP:0002841)2.79554693
36Increased muscle lipid content (HP:0009058)2.79327042
37Autoimmune hemolytic anemia (HP:0001890)2.78586228
38Panhypogammaglobulinemia (HP:0003139)2.78459785
39Keratoconjunctivitis sicca (HP:0001097)2.66026500
40Leukocytosis (HP:0001974)2.64355058
41IgM deficiency (HP:0002850)2.62156923
42Keratoconjunctivitis (HP:0001096)2.59958450
43Meningitis (HP:0001287)2.57433379
44Severe combined immunodeficiency (HP:0004430)2.56190428
45Joint swelling (HP:0001386)2.52987810
46Eosinophilia (HP:0001880)2.52776078
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52181911
48Abnormality of eosinophils (HP:0001879)2.51559564
49Abnormal rod and cone electroretinograms (HP:0008323)2.50696084
50Abnormal mitochondria in muscle tissue (HP:0008316)2.50383124
51Acute necrotizing encephalopathy (HP:0006965)2.49808579
52Obstructive lung disease (HP:0006536)2.48916587
53Chronic obstructive pulmonary disease (HP:0006510)2.48916587
54Recurrent bacterial skin infections (HP:0005406)2.45364813
55Attenuation of retinal blood vessels (HP:0007843)2.45075969
56Vasculitis (HP:0002633)2.44808901
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.44243237
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.44243237
59Hepatocellular necrosis (HP:0001404)2.41131866
60Recurrent bronchitis (HP:0002837)2.40603455
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38828839
62Abnormality of macrophages (HP:0004311)2.38137386
63Abnormality of the prostate (HP:0008775)2.37027702
64Acute hepatic failure (HP:0006554)2.36661124
65Pancytopenia (HP:0001876)2.31117059
66Recurrent viral infections (HP:0004429)2.30713988
67Hepatic necrosis (HP:0002605)2.30078454
68B lymphocytopenia (HP:0010976)2.28472194
69Arterial thrombosis (HP:0004420)2.27692270
70Granulocytopenia (HP:0001913)2.27474638
71Increased CSF lactate (HP:0002490)2.25371512
72Abnormality of B cell number (HP:0010975)2.23783183
73Generalized aminoaciduria (HP:0002909)2.23089441
74Recurrent abscess formation (HP:0002722)2.22732670
75Agammaglobulinemia (HP:0004432)2.21715560
76Recurrent skin infections (HP:0001581)2.19334565
77Pulmonary infiltrates (HP:0002113)2.16942758
78Spontaneous hematomas (HP:0007420)2.15445219
79Hypergammaglobulinemia (HP:0010702)2.10580268
80Abnormal platelet function (HP:0011869)2.09668336
81Impaired platelet aggregation (HP:0003540)2.09668336
82Hemoptysis (HP:0002105)2.05275247
83Progressive macrocephaly (HP:0004481)2.04004383
84Chest pain (HP:0100749)2.03908084
85Thyroiditis (HP:0100646)2.03490974
86Eczematoid dermatitis (HP:0000976)2.03232230
87Decreased central vision (HP:0007663)2.02302671
88Chronic diarrhea (HP:0002028)1.98376208
89Pustule (HP:0200039)1.98179506
90Acute encephalopathy (HP:0006846)1.97992576
91Constricted visual fields (HP:0001133)1.96710060
92Abolished electroretinogram (ERG) (HP:0000550)1.96430338
93Episodic fever (HP:0001954)1.94399684
94Tinnitus (HP:0000360)1.92956071
95Keratitis (HP:0000491)1.92630875
96Lymphoma (HP:0002665)1.90385421
97Cerebral palsy (HP:0100021)1.88364218
98Abnormal pupillary function (HP:0007686)1.88030467
99Combined immunodeficiency (HP:0005387)1.87930721
100Lymphopenia (HP:0001888)1.86703697

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.07990895
2TXK3.93748702
3TESK23.64863378
4TAOK33.27181809
5TEC2.74604766
6BCKDK2.63975655
7RIPK42.56728567
8MAP4K12.53788877
9FES2.52569418
10TIE12.39813378
11MST42.35087987
12MYLK2.21384592
13ITK2.21258080
14MAP3K122.19226217
15ZAP702.14430548
16BTK2.08629551
17SYK2.08028905
18INSRR2.01728541
19BLK1.89753979
20TLK11.87960591
21ADRBK21.85986785
22GRK61.75665292
23EIF2AK11.73263907
24IKBKB1.65835545
25CSF1R1.53136230
26NUAK11.49861443
27KIT1.38362366
28CSK1.35937203
29BMPR21.35581896
30IKBKE1.31641138
31LYN1.30410370
32VRK21.29408201
33JAK31.23678570
34GRK11.23515187
35IRAK41.23011570
36MAP4K21.22245069
37ZAK1.21476354
38SCYL21.20774812
39LCK1.20331953
40HCK1.18784117
41TESK11.17750168
42CDK191.14833043
43MATK1.04808624
44MAP3K111.00628267
45MAP2K60.97939869
46CAMKK20.93283796
47DAPK10.91265720
48PIM10.90844999
49PTK2B0.90220568
50TNK20.87906792
51MAPKAPK30.87313414
52PIK3CG0.83126143
53GRK50.81951200
54TBK10.77988154
55FRK0.75972556
56BMX0.75253884
57VRK10.73486198
58MARK30.73118545
59LIMK10.71318020
60ADRBK10.71082619
61FGR0.70817965
62PRKCQ0.68173498
63IRAK10.66833673
64EPHA30.66350185
65MAP2K30.66062768
66RPS6KA50.61016692
67JAK10.58639773
68ILK0.58367747
69NME10.56288213
70MAP3K140.52360881
71FLT30.50768718
72RPS6KA40.49782073
73TYK20.48347836
74PIM20.47518315
75CAMKK10.45905070
76DAPK30.43499826
77IGF1R0.42812357
78HIPK20.42242225
79JAK20.38673234
80PAK10.37898902
81FYN0.36450836
82PASK0.34813598
83EPHB10.34177941
84SIK30.34075742
85TGFBR20.33214171
86LRRK20.32744677
87GRK70.31784873
88EIF2AK30.31340426
89OXSR10.28213428
90NLK0.27262961
91MAPKAPK20.26958833
92TAOK20.25632807
93ERBB20.25313834
94WNK40.24947991
95ABL10.24176582
96DAPK20.23320979
97RPS6KA60.23168129
98TRPM70.22528067
99STK38L0.21582204
100PRKCA0.20510221

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.12179924
2Allograft rejection_Homo sapiens_hsa053303.60931482
3Autoimmune thyroid disease_Homo sapiens_hsa053203.36107223
4Graft-versus-host disease_Homo sapiens_hsa053322.90746874
5Proteasome_Homo sapiens_hsa030502.87202863
6Hematopoietic cell lineage_Homo sapiens_hsa046402.69315066
7Asthma_Homo sapiens_hsa053102.62451356
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.54198167
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.44479383
10Type I diabetes mellitus_Homo sapiens_hsa049402.42509523
11Antigen processing and presentation_Homo sapiens_hsa046122.09787862
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.09352237
13T cell receptor signaling pathway_Homo sapiens_hsa046601.96793154
14Platelet activation_Homo sapiens_hsa046111.90515717
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89234327
16Oxidative phosphorylation_Homo sapiens_hsa001901.87919218
17Leishmaniasis_Homo sapiens_hsa051401.70936385
18Parkinsons disease_Homo sapiens_hsa050121.70304055
19Measles_Homo sapiens_hsa051621.68918720
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.68380347
21Rheumatoid arthritis_Homo sapiens_hsa053231.67487743
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.50580430
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48909983
24Malaria_Homo sapiens_hsa051441.47914832
25Ribosome_Homo sapiens_hsa030101.45432897
26Staphylococcus aureus infection_Homo sapiens_hsa051501.41356263
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38976465
28Protein export_Homo sapiens_hsa030601.38938972
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36439928
30Caffeine metabolism_Homo sapiens_hsa002321.34683871
31Shigellosis_Homo sapiens_hsa051311.32507165
32Phototransduction_Homo sapiens_hsa047441.31369165
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27692423
34Viral myocarditis_Homo sapiens_hsa054161.27223146
35Arachidonic acid metabolism_Homo sapiens_hsa005901.20721011
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15513187
37Systemic lupus erythematosus_Homo sapiens_hsa053221.14975931
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09465396
39Herpes simplex infection_Homo sapiens_hsa051681.05724462
40RNA polymerase_Homo sapiens_hsa030201.05375609
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04652541
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04415854
43Sulfur metabolism_Homo sapiens_hsa009201.01772928
44Osteoclast differentiation_Homo sapiens_hsa043801.00346788
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.99482011
46Alzheimers disease_Homo sapiens_hsa050100.99155881
47Linoleic acid metabolism_Homo sapiens_hsa005910.98840962
48B cell receptor signaling pathway_Homo sapiens_hsa046620.96533222
49Legionellosis_Homo sapiens_hsa051340.95482574
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94604528
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92263422
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85905392
53Chemokine signaling pathway_Homo sapiens_hsa040620.84835281
54Tuberculosis_Homo sapiens_hsa051520.80719887
55Huntingtons disease_Homo sapiens_hsa050160.76812693
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75766075
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74104822
58Nitrogen metabolism_Homo sapiens_hsa009100.72589690
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72116293
60Collecting duct acid secretion_Homo sapiens_hsa049660.69568119
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68104958
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66324387
63Regulation of autophagy_Homo sapiens_hsa041400.64545952
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.62125305
65Pyrimidine metabolism_Homo sapiens_hsa002400.62098373
66Olfactory transduction_Homo sapiens_hsa047400.61957996
67Pertussis_Homo sapiens_hsa051330.61663929
68Phagosome_Homo sapiens_hsa041450.61132659
69Influenza A_Homo sapiens_hsa051640.60470114
70Purine metabolism_Homo sapiens_hsa002300.57957097
71Toxoplasmosis_Homo sapiens_hsa051450.57952647
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55382435
73Chemical carcinogenesis_Homo sapiens_hsa052040.54772314
74Basal transcription factors_Homo sapiens_hsa030220.53954017
75Salmonella infection_Homo sapiens_hsa051320.52729597
76Selenocompound metabolism_Homo sapiens_hsa004500.52416832
77Nucleotide excision repair_Homo sapiens_hsa034200.50195940
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.48298907
79TNF signaling pathway_Homo sapiens_hsa046680.44545691
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.42693715
81Peroxisome_Homo sapiens_hsa041460.42454397
82Epstein-Barr virus infection_Homo sapiens_hsa051690.42332382
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41133209
84African trypanosomiasis_Homo sapiens_hsa051430.41048585
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40970553
86One carbon pool by folate_Homo sapiens_hsa006700.39844258
87Apoptosis_Homo sapiens_hsa042100.39091420
88Cardiac muscle contraction_Homo sapiens_hsa042600.38769155
89Mismatch repair_Homo sapiens_hsa034300.38545362
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.36842094
91Fanconi anemia pathway_Homo sapiens_hsa034600.36400998
92RNA degradation_Homo sapiens_hsa030180.35414943
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.33809058
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32222122
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32070356
96Taste transduction_Homo sapiens_hsa047420.29273049
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28740695
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27207829
99Serotonergic synapse_Homo sapiens_hsa047260.27150389
100Viral carcinogenesis_Homo sapiens_hsa052030.26848368

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