TAGLN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.61261081
2pyrimidine nucleobase catabolic process (GO:0006208)5.60774050
3neuron cell-cell adhesion (GO:0007158)5.56619176
4vocalization behavior (GO:0071625)5.08825989
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.04608666
6glutamate secretion (GO:0014047)5.03555074
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.93383987
8nucleobase catabolic process (GO:0046113)4.65781650
9regulation of synaptic vesicle exocytosis (GO:2000300)4.56980980
10protein localization to synapse (GO:0035418)4.55050882
11dendritic spine morphogenesis (GO:0060997)4.45897959
12establishment of mitochondrion localization (GO:0051654)4.39414836
13regulation of glutamate receptor signaling pathway (GO:1900449)4.38987111
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.36069645
15neuronal action potential propagation (GO:0019227)4.34971054
16neuronal ion channel clustering (GO:0045161)4.31492073
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.23496400
18neurotransmitter secretion (GO:0007269)4.22209908
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.18517638
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.14772553
21presynaptic membrane assembly (GO:0097105)4.04260626
22regulation of synaptic vesicle transport (GO:1902803)4.00773608
23neuron-neuron synaptic transmission (GO:0007270)3.96791062
24dopamine transport (GO:0015872)3.94741187
25behavioral response to nicotine (GO:0035095)3.93433228
26synaptic vesicle maturation (GO:0016188)3.93234626
27presynaptic membrane organization (GO:0097090)3.89731502
28locomotory exploration behavior (GO:0035641)3.86085744
29energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.84427160
30ATP hydrolysis coupled proton transport (GO:0015991)3.84427160
31neurotransmitter-gated ion channel clustering (GO:0072578)3.84165705
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.82909504
33neuron recognition (GO:0008038)3.82907927
34negative regulation of synaptic transmission, GABAergic (GO:0032229)3.80547867
35glutamate receptor signaling pathway (GO:0007215)3.73173925
36response to histamine (GO:0034776)3.73083241
37postsynaptic membrane organization (GO:0001941)3.69770749
38neuromuscular synaptic transmission (GO:0007274)3.69644600
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.68727709
40synaptic transmission, glutamatergic (GO:0035249)3.67844972
41dopamine biosynthetic process (GO:0042416)3.67788568
42neurotransmitter transport (GO:0006836)3.66677816
43positive regulation of synapse assembly (GO:0051965)3.66317348
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60381341
45mitochondrion transport along microtubule (GO:0047497)3.53603452
46establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.53603452
47transferrin transport (GO:0033572)3.52363003
48exploration behavior (GO:0035640)3.52296765
49behavioral response to cocaine (GO:0048148)3.51904235
50substrate-independent telencephalic tangential migration (GO:0021826)3.51004560
51substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.51004560
52regulation of neurotransmitter levels (GO:0001505)3.50122139
53positive regulation of dendritic spine morphogenesis (GO:0061003)3.49860986
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44228986
55cerebellar granule cell differentiation (GO:0021707)3.43199828
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.42891386
57regulation of glutamate secretion (GO:0014048)3.42720852
58negative regulation of microtubule polymerization (GO:0031115)3.41044068
59axonal fasciculation (GO:0007413)3.40277089
60cellular potassium ion homeostasis (GO:0030007)3.38200555
61regulation of synapse structural plasticity (GO:0051823)3.36877483
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36107582
63catecholamine transport (GO:0051937)3.35685062
64layer formation in cerebral cortex (GO:0021819)3.34924915
65regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34794839
66synaptic vesicle endocytosis (GO:0048488)3.34384811
67proline transport (GO:0015824)3.32991874
68regulation of dopamine metabolic process (GO:0042053)3.32946566
69regulation of catecholamine metabolic process (GO:0042069)3.32946566
70synaptic transmission, dopaminergic (GO:0001963)3.31971160
71neurofilament cytoskeleton organization (GO:0060052)3.31778073
72regulation of postsynaptic membrane potential (GO:0060078)3.31298854
73regulation of neuronal synaptic plasticity (GO:0048168)3.31239508
74positive regulation of synapse maturation (GO:0090129)3.30614006
75axon ensheathment in central nervous system (GO:0032291)3.29890210
76central nervous system myelination (GO:0022010)3.29890210
77long-term synaptic potentiation (GO:0060291)3.28588292
78cerebellar Purkinje cell differentiation (GO:0021702)3.28117139
79dendrite morphogenesis (GO:0048813)3.28115925
80central nervous system projection neuron axonogenesis (GO:0021952)3.27926243
81regulation of dendritic spine morphogenesis (GO:0061001)3.27044319
82adult walking behavior (GO:0007628)3.26982192
83ferric iron transport (GO:0015682)3.26871097
84trivalent inorganic cation transport (GO:0072512)3.26871097
85regulation of long-term neuronal synaptic plasticity (GO:0048169)3.26542837
86G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25812841
87positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25586203
88regulation of neurotransmitter secretion (GO:0046928)3.23605930
89positive regulation of neurotransmitter transport (GO:0051590)3.21645704
90regulation of synaptic transmission, glutamatergic (GO:0051966)3.21228398
91auditory behavior (GO:0031223)3.20159459
92negative regulation of dendrite morphogenesis (GO:0050774)3.20029327
93regulation of vesicle fusion (GO:0031338)3.19988602
94cell migration in hindbrain (GO:0021535)3.19394275
95energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19003445
96ATP synthesis coupled proton transport (GO:0015986)3.19003445
97synaptic vesicle transport (GO:0048489)3.18975614
98establishment of synaptic vesicle localization (GO:0097480)3.18975614
99mating behavior (GO:0007617)3.18839270
100chaperone-mediated protein transport (GO:0072321)3.17970158
101regulation of protein kinase A signaling (GO:0010738)3.17576817
102transmission of nerve impulse (GO:0019226)3.16502125
103mechanosensory behavior (GO:0007638)3.14694986
104regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.13161097
105positive regulation of dendritic spine development (GO:0060999)3.12890707
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11994165
107response to cocaine (GO:0042220)3.11497265
108neurotransmitter uptake (GO:0001504)3.11379605
109dendritic spine organization (GO:0097061)3.10557993
110opioid receptor signaling pathway (GO:0038003)3.10079276
111regulation of neurotransmitter transport (GO:0051588)3.08702782
112positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07405912
113regulation of voltage-gated calcium channel activity (GO:1901385)3.06411257
114synapse assembly (GO:0007416)3.05622014
115positive regulation of neurotransmitter secretion (GO:0001956)3.04851818
116negative regulation of dendrite development (GO:2000171)3.01010085
117regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00278681
118membrane depolarization during action potential (GO:0086010)2.98785663
119gamma-aminobutyric acid transport (GO:0015812)2.98234069
120sodium ion export (GO:0071436)2.96944637
121negative regulation of neurotransmitter transport (GO:0051589)2.96834576
122response to auditory stimulus (GO:0010996)2.96524204
123regulation of synapse assembly (GO:0051963)2.96517767
124membrane depolarization (GO:0051899)2.96431520
125synaptic transmission (GO:0007268)2.96108950
126positive regulation of membrane potential (GO:0045838)2.95502852
127synapse organization (GO:0050808)2.95479769
128behavioral defense response (GO:0002209)2.93937913
129behavioral fear response (GO:0001662)2.93937913
130acidic amino acid transport (GO:0015800)2.92212957
131negative regulation of axonogenesis (GO:0050771)2.89485958
132retinal ganglion cell axon guidance (GO:0031290)2.87410036
133cerebral cortex radially oriented cell migration (GO:0021799)2.85769632

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.88803035
2GBX2_23144817_ChIP-Seq_PC3_Human4.13932700
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21752672
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07110556
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01762262
6TAF15_26573619_Chip-Seq_HEK293_Human2.94825035
7REST_21632747_ChIP-Seq_MESCs_Mouse2.72817835
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.70361747
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64400302
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.64012462
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61211227
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60760646
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60760646
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59300879
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56922055
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.43312290
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33739369
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31424909
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31230892
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.27450699
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.24757425
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20811350
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14894985
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11527547
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10058584
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09086265
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.07662349
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05847626
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.04076006
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.94624595
31P300_19829295_ChIP-Seq_ESCs_Human1.78646365
32DROSHA_22980978_ChIP-Seq_HELA_Human1.76810975
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75992595
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.74523906
35SMAD4_21799915_ChIP-Seq_A2780_Human1.73866838
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71806148
37AR_21572438_ChIP-Seq_LNCaP_Human1.67975460
38VDR_22108803_ChIP-Seq_LS180_Human1.66390554
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65035262
40IGF1R_20145208_ChIP-Seq_DFB_Human1.63143410
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59392577
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57109938
43RNF2_27304074_Chip-Seq_NSC_Mouse1.55019039
44ZNF274_21170338_ChIP-Seq_K562_Hela1.49532831
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48393321
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46944019
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46317727
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44107801
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.43326399
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41197882
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41117031
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41064589
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.39832656
54FUS_26573619_Chip-Seq_HEK293_Human1.38393055
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38095444
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.37562950
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37217395
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.35855427
59AR_25329375_ChIP-Seq_VCAP_Human1.34818278
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32327482
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31972197
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31629537
63* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29427261
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.25829632
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23848877
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23512009
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19783380
68ER_23166858_ChIP-Seq_MCF-7_Human1.19644923
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.13177840
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11957437
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.10065279
72RUNX2_22187159_ChIP-Seq_PCA_Human1.09454966
73JUN_21703547_ChIP-Seq_K562_Human1.08870127
74STAT3_23295773_ChIP-Seq_U87_Human1.08117745
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07261019
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06444141
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.06086749
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05540114
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04990938
80TCF4_23295773_ChIP-Seq_U87_Human1.04756101
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03574725
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.01280567
83BCAT_22108803_ChIP-Seq_LS180_Human1.00763223
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.00067176
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99912794
86ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99845483
87P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98648942
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98312499
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98282482
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98260039
91TP53_20018659_ChIP-ChIP_R1E_Mouse0.97263468
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95772173
93* AR_19668381_ChIP-Seq_PC3_Human0.95673792
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94963695
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94963695
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.93420676
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92963508
98CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92300709
99EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92031465
100SOX9_26525672_Chip-Seq_HEART_Mouse0.91830634
101KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91406954
102DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90985649
103EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89191609
104TP53_18474530_ChIP-ChIP_U2OS_Human0.87567748
105CTCF_27219007_Chip-Seq_Bcells_Human0.87130081
106RING1B_27294783_Chip-Seq_NPCs_Mouse0.87091311
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87021594
108WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86512108
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86313874
110KDM2B_26808549_Chip-Seq_REH_Human0.86167691
111EWS_26573619_Chip-Seq_HEK293_Human0.86102452
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.85934443
113YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85819092
114NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85798229
115STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84833448
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84071159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.58112912
2MP0004859_abnormal_synaptic_plasticity4.60580556
3MP0003635_abnormal_synaptic_transmissio3.65927429
4MP0001968_abnormal_touch/_nociception3.25098988
5MP0009046_muscle_twitch3.24835304
6MP0009745_abnormal_behavioral_response3.23606267
7MP0006276_abnormal_autonomic_nervous3.09393422
8MP0002064_seizures3.08200864
9MP0004270_analgesia2.99495828
10MP0002063_abnormal_learning/memory/cond2.98231389
11MP0002736_abnormal_nociception_after2.84676019
12MP0002572_abnormal_emotion/affect_behav2.80402824
13MP0001529_abnormal_vocalization2.79290802
14MP0002734_abnormal_mechanical_nocicepti2.57747471
15MP0002735_abnormal_chemical_nociception2.55475632
16MP0001905_abnormal_dopamine_level2.48891397
17MP0001440_abnormal_grooming_behavior2.48689423
18MP0002272_abnormal_nervous_system2.48184745
19MP0005423_abnormal_somatic_nervous2.48072753
20MP0002822_catalepsy2.34477168
21MP0001486_abnormal_startle_reflex2.33063975
22MP0001501_abnormal_sleep_pattern2.27117729
23MP0003122_maternal_imprinting2.21259172
24MP0002067_abnormal_sensory_capabilities2.17882176
25MP0002733_abnormal_thermal_nociception2.14660655
26MP0001970_abnormal_pain_threshold2.04573750
27MP0005386_behavior/neurological_phenoty2.01395043
28MP0004924_abnormal_behavior2.01395043
29MP0002184_abnormal_innervation1.95832906
30MP0000778_abnormal_nervous_system1.90889584
31MP0002557_abnormal_social/conspecific_i1.81281469
32MP0005646_abnormal_pituitary_gland1.81078283
33MP0001984_abnormal_olfaction1.75968836
34MP0004142_abnormal_muscle_tone1.68141985
35MP0004858_abnormal_nervous_system1.52383418
36MP0005645_abnormal_hypothalamus_physiol1.51449620
37MP0004811_abnormal_neuron_physiology1.51039352
38MP0001188_hyperpigmentation1.50169397
39MP0008569_lethality_at_weaning1.48691743
40MP0001502_abnormal_circadian_rhythm1.47655414
41MP0003787_abnormal_imprinting1.46400008
42MP0003879_abnormal_hair_cell1.41912110
43MP0000955_abnormal_spinal_cord1.40773958
44MP0002837_dystrophic_cardiac_calcinosis1.39127191
45MP0002066_abnormal_motor_capabilities/c1.37280840
46MP0002882_abnormal_neuron_morphology1.36134732
47MP0002909_abnormal_adrenal_gland1.32119539
48MP0009780_abnormal_chondrocyte_physiolo1.30395940
49MP0003329_amyloid_beta_deposits1.30058211
50MP0003123_paternal_imprinting1.25170313
51MP0000751_myopathy1.22970314
52MP0008872_abnormal_physiological_respon1.19874454
53MP0008789_abnormal_olfactory_epithelium1.17948047
54MP0004742_abnormal_vestibular_system1.16358905
55MP0010386_abnormal_urinary_bladder1.16032531
56MP0004133_heterotaxia1.10358546
57MP0002876_abnormal_thyroid_physiology1.09879511
58MP0008877_abnormal_DNA_methylation1.08912051
59MP0002638_abnormal_pupillary_reflex1.06846932
60MP0002152_abnormal_brain_morphology1.02822857
61MP0000631_abnormal_neuroendocrine_gland1.02320437
62MP0005551_abnormal_eye_electrophysiolog0.99470532
63MP0003633_abnormal_nervous_system0.99391394
64MP0001664_abnormal_digestion0.95836745
65MP0005499_abnormal_olfactory_system0.95104995
66MP0005394_taste/olfaction_phenotype0.95104995
67MP0001963_abnormal_hearing_physiology0.94731462
68MP0003861_abnormal_nervous_system0.93197207
69MP0003183_abnormal_peptide_metabolism0.93005853
70MP0003631_nervous_system_phenotype0.92881925
71MP0002069_abnormal_eating/drinking_beha0.92363802
72MP0002229_neurodegeneration0.92239487
73MP0005535_abnormal_body_temperature0.92045939
74MP0003011_delayed_dark_adaptation0.90485617
75MP0002752_abnormal_somatic_nervous0.89850842
76MP0004145_abnormal_muscle_electrophysio0.89068062
77MP0003938_abnormal_ear_development0.87653946
78MP0002751_abnormal_autonomic_nervous0.85433811
79MP0004885_abnormal_endolymph0.81529600
80MP0005187_abnormal_penis_morphology0.80182812
81MP0003121_genomic_imprinting0.80179203
82MP0004085_abnormal_heartbeat0.77717020
83MP0001177_atelectasis0.73078382
84MP0008874_decreased_physiological_sensi0.72376757
85MP0000013_abnormal_adipose_tissue0.71034765
86MP0006035_abnormal_mitochondrial_morpho0.70422516
87MP0004215_abnormal_myocardial_fiber0.69692659
88MP0002332_abnormal_exercise_endurance0.68994257
89MP0006072_abnormal_retinal_apoptosis0.68739462
90MP0000026_abnormal_inner_ear0.68509278
91MP0005409_darkened_coat_color0.67452064
92MP0003119_abnormal_digestive_system0.67132106
93MP0003632_abnormal_nervous_system0.66022095
94MP0003634_abnormal_glial_cell0.65858482
95MP0001943_abnormal_respiration0.65236040
96MP0003890_abnormal_embryonic-extraembry0.64784342
97MP0000566_synostosis0.64690141
98MP0002928_abnormal_bile_duct0.63752330
99MP0005195_abnormal_posterior_eye0.63652814
100MP0000538_abnormal_urinary_bladder0.63387188
101MP0005171_absent_coat_pigmentation0.63160375
102MP0000920_abnormal_myelination0.62861770
103MP0003690_abnormal_glial_cell0.62492356
104MP0005167_abnormal_blood-brain_barrier0.62431004
105MP0002234_abnormal_pharynx_morphology0.62293716
106MP0001986_abnormal_taste_sensitivity0.62001651
107MP0002090_abnormal_vision0.60140338
108MP0005379_endocrine/exocrine_gland_phen0.59732344
109MP0008995_early_reproductive_senescence0.58692266
110MP0000049_abnormal_middle_ear0.58135658
111MP0002653_abnormal_ependyma_morphology0.57879930
112MP0003137_abnormal_impulse_conducting0.56943389
113MP0002163_abnormal_gland_morphology0.56618799
114MP0001485_abnormal_pinna_reflex0.56248636
115MP0002081_perinatal_lethality0.55814297
116MP0000569_abnormal_digit_pigmentation0.54437681
117MP0002102_abnormal_ear_morphology0.54368459
118MP0005253_abnormal_eye_physiology0.53205108
119MP0006292_abnormal_olfactory_placode0.51649803
120MP0002082_postnatal_lethality0.51200873
121MP0010770_preweaning_lethality0.51200873

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.05102771
2Myokymia (HP:0002411)5.66394249
3Focal seizures (HP:0007359)5.02966016
4Limb dystonia (HP:0002451)4.98041753
5Atonic seizures (HP:0010819)4.97837276
6Epileptic encephalopathy (HP:0200134)4.87306587
7Visual hallucinations (HP:0002367)4.67432935
8Febrile seizures (HP:0002373)4.47807353
9Progressive cerebellar ataxia (HP:0002073)4.11014599
10Absence seizures (HP:0002121)3.95820344
11Pheochromocytoma (HP:0002666)3.85196352
12Acute necrotizing encephalopathy (HP:0006965)3.74517369
13Hyperventilation (HP:0002883)3.73678646
14Dialeptic seizures (HP:0011146)3.65794629
15Failure to thrive in infancy (HP:0001531)3.59845275
16Neuroendocrine neoplasm (HP:0100634)3.58273519
17Abnormal hair whorl (HP:0010721)3.50067316
18Abnormal mitochondria in muscle tissue (HP:0008316)3.48471241
19Generalized tonic-clonic seizures (HP:0002069)3.47123821
20Progressive macrocephaly (HP:0004481)3.34083332
21Polyphagia (HP:0002591)3.23397417
22Broad-based gait (HP:0002136)3.15930860
23Amblyopia (HP:0000646)3.10628519
24Mitochondrial inheritance (HP:0001427)3.03921600
25Abnormal eating behavior (HP:0100738)3.03517784
26Hypothermia (HP:0002045)2.91738882
27Truncal ataxia (HP:0002078)2.82270408
28Gait imbalance (HP:0002141)2.81447534
29Acute encephalopathy (HP:0006846)2.81094775
30Poor suck (HP:0002033)2.77515412
31Gaze-evoked nystagmus (HP:0000640)2.74634109
32Retinal dysplasia (HP:0007973)2.70878874
33Torticollis (HP:0000473)2.70618569
34Anxiety (HP:0000739)2.70046888
35Impaired vibration sensation in the lower limbs (HP:0002166)2.67724207
36Hypoventilation (HP:0002791)2.58877138
37Amyotrophic lateral sclerosis (HP:0007354)2.58333795
38Degeneration of the lateral corticospinal tracts (HP:0002314)2.54003279
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.54003279
40Medial flaring of the eyebrow (HP:0010747)2.53858301
41Congenital primary aphakia (HP:0007707)2.52982528
42Action tremor (HP:0002345)2.51183361
43Status epilepticus (HP:0002133)2.50057765
44Lissencephaly (HP:0001339)2.49768600
45Epileptiform EEG discharges (HP:0011182)2.48135005
46Increased CSF lactate (HP:0002490)2.47623229
47Cerebral hypomyelination (HP:0006808)2.47265421
48Supranuclear gaze palsy (HP:0000605)2.44757901
49Progressive inability to walk (HP:0002505)2.42758095
50Peripheral hypomyelination (HP:0007182)2.41754894
51Spastic tetraplegia (HP:0002510)2.40076078
52Cortical dysplasia (HP:0002539)2.38931534
53Nephrogenic diabetes insipidus (HP:0009806)2.37895942
54Abnormality of the labia minora (HP:0012880)2.36817780
55Esotropia (HP:0000565)2.36557233
56Mutism (HP:0002300)2.34291891
57Depression (HP:0000716)2.32004170
58Intention tremor (HP:0002080)2.31602053
59Specific learning disability (HP:0001328)2.31210306
60EEG with generalized epileptiform discharges (HP:0011198)2.30968018
61Hepatocellular necrosis (HP:0001404)2.30469745
62Narrow nasal bridge (HP:0000446)2.30009327
63Optic disc pallor (HP:0000543)2.29296780
64Dysdiadochokinesis (HP:0002075)2.29234378
65Genital tract atresia (HP:0001827)2.28335912
66Oligomenorrhea (HP:0000876)2.27491782
67Fetal akinesia sequence (HP:0001989)2.26524433
68Hepatoblastoma (HP:0002884)2.25937292
69Vaginal atresia (HP:0000148)2.24998762
70Ankle clonus (HP:0011448)2.23264750
71Drooling (HP:0002307)2.22936730
72Excessive salivation (HP:0003781)2.22936730
73Morphological abnormality of the pyramidal tract (HP:0002062)2.22447204
74Poor eye contact (HP:0000817)2.22395051
75Insidious onset (HP:0003587)2.20421247
76Termporal pattern (HP:0011008)2.20421247
77Delusions (HP:0000746)2.20183440
78Lower limb muscle weakness (HP:0007340)2.18589618
79Dysmetria (HP:0001310)2.17987574
80Pachygyria (HP:0001302)2.17888971
81Inability to walk (HP:0002540)2.17418134
82Hypsarrhythmia (HP:0002521)2.15552771
83Craniofacial dystonia (HP:0012179)2.10959738
84Bradykinesia (HP:0002067)2.09033218
85Abnormality of binocular vision (HP:0011514)2.08281056
86Diplopia (HP:0000651)2.08281056
87Postural instability (HP:0002172)2.05978636
88Cerebral inclusion bodies (HP:0100314)2.05263363
89Abnormality of the lower motor neuron (HP:0002366)2.02766886
90Neurofibrillary tangles (HP:0002185)2.02763348
91Hypoplasia of the corpus callosum (HP:0002079)2.00650739
92Split foot (HP:0001839)2.00461959
93Hyperthyroidism (HP:0000836)2.00230629
94Urinary bladder sphincter dysfunction (HP:0002839)2.00034681
95Spastic gait (HP:0002064)1.98935892
96Neoplasm of the peripheral nervous system (HP:0100007)1.98478964
97Abnormal social behavior (HP:0012433)1.97987560
98Impaired social interactions (HP:0000735)1.97987560
99Hemiparesis (HP:0001269)1.97599947
100Urinary urgency (HP:0000012)1.97106293
101Abnormality of the corticospinal tract (HP:0002492)1.96919172
102CNS hypomyelination (HP:0003429)1.93524589
103Scanning speech (HP:0002168)1.92979530
104Ulnar claw (HP:0001178)1.89657169
105Psychosis (HP:0000709)1.88952655
106Incomplete penetrance (HP:0003829)1.88650446
107Megalencephaly (HP:0001355)1.86179041
108Increased serum pyruvate (HP:0003542)1.85977158
109Abnormality of glycolysis (HP:0004366)1.85977158
110Leukodystrophy (HP:0002415)1.85715150
111Sleep apnea (HP:0010535)1.85172132
112Postural tremor (HP:0002174)1.84576706
113Protruding tongue (HP:0010808)1.84048806
114Delayed gross motor development (HP:0002194)1.83724019
115Hypoplasia of the brainstem (HP:0002365)1.83627763
116Aplasia/Hypoplasia of the brainstem (HP:0007362)1.83627763
117Agitation (HP:0000713)1.82928369
118Impaired smooth pursuit (HP:0007772)1.82602408
119Muscular hypotonia of the trunk (HP:0008936)1.80789116
120Poor coordination (HP:0002370)1.80485139
121Hemiplegia (HP:0002301)1.80397791
122Genetic anticipation (HP:0003743)1.79504762
123Generalized hypotonia (HP:0001290)1.79492294
124Focal dystonia (HP:0004373)1.79439051
125Akinesia (HP:0002304)1.78379782
126Absent speech (HP:0001344)1.78045859
127Oligodactyly (hands) (HP:0001180)1.77824557
128Gait ataxia (HP:0002066)1.76430703
129Nephronophthisis (HP:0000090)1.76279979
130Type II lissencephaly (HP:0007260)1.76182917
131Impaired pain sensation (HP:0007328)1.75358466
132Abnormality of pain sensation (HP:0010832)1.75358466
133Anomalous pulmonary venous return (HP:0010772)1.74950366
134Clonus (HP:0002169)1.74855125
135Molar tooth sign on MRI (HP:0002419)1.73723278
136Abnormality of midbrain morphology (HP:0002418)1.73723278
137Impaired vibratory sensation (HP:0002495)1.73499966
138Pancreatic fibrosis (HP:0100732)1.72176850
139Papilledema (HP:0001085)1.70725673

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.72166718
2MAP3K124.08712191
3NTRK33.71001000
4MAP3K43.28570799
5MAP2K73.13926151
6EPHA43.01630556
7MAP3K92.71462273
8MARK12.55541508
9MINK12.46697133
10CDK192.35626958
11GRK52.23554741
12MAP2K42.15852373
13PLK22.14469102
14DAPK22.01462628
15NTRK21.98002679
16PINK11.96254800
17PNCK1.92987174
18MAPK131.70897196
19SIK31.64876591
20DAPK11.64045773
21ARAF1.63961663
22OXSR11.39781366
23NME11.36795973
24KSR11.35366423
25CDK51.27590340
26MAP4K21.24519292
27TNIK1.23888497
28PRPF4B1.23334004
29CAMKK21.22585412
30PRKCG1.21111398
31PAK61.19675031
32TRIM281.19392492
33PRKD31.16267336
34RIPK41.14122114
35CAMK2A1.13977459
36CCNB11.10810046
37AKT31.08449331
38UHMK11.07915965
39PTK2B1.05754726
40NTRK11.04383054
41ADRBK21.04066175
42KSR21.03060800
43TSSK61.02603335
44CDK181.00917611
45BCR1.00618804
46MAPKAPK51.00569851
47DYRK1B0.99739824
48CAMK2B0.98081641
49CSNK1A1L0.97891211
50GRK70.97798518
51ADRBK10.96221109
52SGK2230.95341917
53SGK4940.95341917
54FGR0.93583183
55SIK20.92329004
56CDK150.92080190
57CDK140.91051936
58CSNK1G20.90565194
59PHKG20.83493570
60PHKG10.83493570
61CAMKK10.82181670
62PKN10.80917852
63FES0.80475619
64CDK11A0.79833572
65GRK60.78883599
66SGK20.78231748
67DYRK1A0.77878836
68BMPR1B0.76669563
69BRAF0.75683398
70DYRK30.75445754
71EPHA30.73895399
72ERBB30.72315674
73CSNK1G30.72275995
74MARK20.71460865
75MYLK0.70169483
76PRKCH0.67973333
77LATS20.65111391
78PRKCE0.63611850
79WNK30.63524068
80GRK10.62796418
81TYRO30.62327066
82BMPR20.62295583
83TNK20.61694058
84CAMK2D0.60504388
85CAMK2G0.58937654
86LMTK20.57679698
87LIMK10.57258399
88RET0.56988221
89EPHB20.56869419
90FER0.56358270
91CAMK10.55730893
92MAP3K130.52011654
93DAPK30.50217416
94MUSK0.50092589
95STK390.49668833
96BCKDK0.49166576
97PAK30.47211343
98ROCK20.45074080
99STK110.43727718
100PDK30.42779352
101PDK40.42779352
102CSNK1E0.42662915
103RPS6KA30.41739912
104ERBB20.41694214
105SGK10.40673969
106STK380.40648602
107MAP2K10.40216890
108FGFR20.40049592
109WNK40.39616105
110CAMK40.39553687
111PRKACA0.39480922
112MAP3K60.38650188
113CSNK1A10.36094195
114CSNK1D0.35613965
115CSNK1G10.35453709
116PRKG10.34777799
117PRKAA10.34711089
118PRKCZ0.33994078
119SGK30.33609445
120MAP3K110.33538965
121MAPK100.33148436
122MAP3K20.31859141
123CAMK1G0.31690004
124FYN0.30701863
125DYRK20.30322117
126MAPK120.30176273
127RAF10.30033227
128PRKCA0.29668786
129MAPK80.28797309
130TESK10.28420460
131INSRR0.25648575

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.14642733
2Nicotine addiction_Homo sapiens_hsa050334.10182528
3Collecting duct acid secretion_Homo sapiens_hsa049663.28435220
4Oxidative phosphorylation_Homo sapiens_hsa001903.26855620
5Parkinsons disease_Homo sapiens_hsa050122.67401929
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63376169
7Amphetamine addiction_Homo sapiens_hsa050312.49461015
8GABAergic synapse_Homo sapiens_hsa047272.45331449
9Olfactory transduction_Homo sapiens_hsa047402.33052147
10Circadian entrainment_Homo sapiens_hsa047132.29483766
11Morphine addiction_Homo sapiens_hsa050322.25170037
12Long-term potentiation_Homo sapiens_hsa047202.22990925
13Alzheimers disease_Homo sapiens_hsa050102.18093885
14Glutamatergic synapse_Homo sapiens_hsa047242.17973287
15Dopaminergic synapse_Homo sapiens_hsa047282.16977192
16Taste transduction_Homo sapiens_hsa047422.02881665
17Cocaine addiction_Homo sapiens_hsa050302.00969297
18Vibrio cholerae infection_Homo sapiens_hsa051101.99525010
19Serotonergic synapse_Homo sapiens_hsa047261.86756179
20Salivary secretion_Homo sapiens_hsa049701.78774925
21Cardiac muscle contraction_Homo sapiens_hsa042601.76906483
22Huntingtons disease_Homo sapiens_hsa050161.74960664
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73263427
24Insulin secretion_Homo sapiens_hsa049111.69725865
25Cholinergic synapse_Homo sapiens_hsa047251.66802579
26Long-term depression_Homo sapiens_hsa047301.64262411
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60183903
28Renin secretion_Homo sapiens_hsa049241.56461286
29Gastric acid secretion_Homo sapiens_hsa049711.49092521
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49051595
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.46310967
32Calcium signaling pathway_Homo sapiens_hsa040201.45243985
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33477164
34Oxytocin signaling pathway_Homo sapiens_hsa049211.29623917
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27734470
36Gap junction_Homo sapiens_hsa045401.22092902
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17851116
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17802251
39Phototransduction_Homo sapiens_hsa047441.13997817
40GnRH signaling pathway_Homo sapiens_hsa049121.09954013
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03085744
42Rheumatoid arthritis_Homo sapiens_hsa053230.95768923
43Axon guidance_Homo sapiens_hsa043600.95426766
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90415885
45cAMP signaling pathway_Homo sapiens_hsa040240.85235625
46Butanoate metabolism_Homo sapiens_hsa006500.83749398
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83078663
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81691398
49Melanogenesis_Homo sapiens_hsa049160.80880643
50Estrogen signaling pathway_Homo sapiens_hsa049150.80481168
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78024049
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77968709
53ErbB signaling pathway_Homo sapiens_hsa040120.71839536
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70114104
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69775539
56Phagosome_Homo sapiens_hsa041450.69433375
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.67169617
58Alcoholism_Homo sapiens_hsa050340.65070759
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64267952
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63658574
61Oocyte meiosis_Homo sapiens_hsa041140.63639783
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62251978
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61825565
64Glioma_Homo sapiens_hsa052140.61064830
65Pyruvate metabolism_Homo sapiens_hsa006200.60270945
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57374886
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54504524
68Type II diabetes mellitus_Homo sapiens_hsa049300.54388386
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50799042
70Pancreatic secretion_Homo sapiens_hsa049720.50398041
71Hedgehog signaling pathway_Homo sapiens_hsa043400.50175409
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49678246
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48758852
74Steroid biosynthesis_Homo sapiens_hsa001000.47675110
75Glucagon signaling pathway_Homo sapiens_hsa049220.47520293
76Hippo signaling pathway_Homo sapiens_hsa043900.47307233
77Circadian rhythm_Homo sapiens_hsa047100.46692088
78MAPK signaling pathway_Homo sapiens_hsa040100.46301834
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46077138
80Thyroid hormone synthesis_Homo sapiens_hsa049180.45432457
81Dilated cardiomyopathy_Homo sapiens_hsa054140.45049633
82Ether lipid metabolism_Homo sapiens_hsa005650.43339815
83Bile secretion_Homo sapiens_hsa049760.42391068
84Protein export_Homo sapiens_hsa030600.39468005
85Type I diabetes mellitus_Homo sapiens_hsa049400.38363138
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36928292
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.36921382
88African trypanosomiasis_Homo sapiens_hsa051430.36645134
89Ras signaling pathway_Homo sapiens_hsa040140.34859913
90Dorso-ventral axis formation_Homo sapiens_hsa043200.34155401
91Phenylalanine metabolism_Homo sapiens_hsa003600.33211310
92Inositol phosphate metabolism_Homo sapiens_hsa005620.33186976
93Regulation of autophagy_Homo sapiens_hsa041400.32027121
94Proteasome_Homo sapiens_hsa030500.30978146
95Tyrosine metabolism_Homo sapiens_hsa003500.28189938
96AMPK signaling pathway_Homo sapiens_hsa041520.27671548
97Choline metabolism in cancer_Homo sapiens_hsa052310.27648634
98Basal cell carcinoma_Homo sapiens_hsa052170.26405713
99Wnt signaling pathway_Homo sapiens_hsa043100.26360090
100Vitamin B6 metabolism_Homo sapiens_hsa007500.26211771
101Endocytosis_Homo sapiens_hsa041440.26065219
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.25895911
103Tight junction_Homo sapiens_hsa045300.25466602
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24967732
105Arginine and proline metabolism_Homo sapiens_hsa003300.24820274
106Ovarian steroidogenesis_Homo sapiens_hsa049130.24614062
107Rap1 signaling pathway_Homo sapiens_hsa040150.23046375
108Prion diseases_Homo sapiens_hsa050200.22519784
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22053381
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20599264
111Insulin signaling pathway_Homo sapiens_hsa049100.18815223
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18372933
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18016908
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17271688
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.17213711
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16448847
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.15758223
118Melanoma_Homo sapiens_hsa052180.15673409
119Renal cell carcinoma_Homo sapiens_hsa052110.15521757
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.15248224

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