TALDO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.63753017
2axon ensheathment in central nervous system (GO:0032291)8.63753017
3fatty acid elongation (GO:0030497)7.04951487
4cholesterol biosynthetic process (GO:0006695)5.26166709
5ensheathment of neurons (GO:0007272)4.96299201
6axon ensheathment (GO:0008366)4.96299201
7amyloid precursor protein metabolic process (GO:0042982)4.92063761
8myelination (GO:0042552)4.89546004
9neutrophil activation involved in immune response (GO:0002283)4.85451211
10response to peptidoglycan (GO:0032494)4.73826911
11amyloid precursor protein catabolic process (GO:0042987)4.68969140
12sterol biosynthetic process (GO:0016126)4.67165964
13leukocyte migration involved in inflammatory response (GO:0002523)4.52402389
14positive regulation of gamma-delta T cell activation (GO:0046645)4.47907561
15positive regulation by symbiont of host defense response (GO:0052509)4.41569546
16modulation by symbiont of host defense response (GO:0052031)4.41569546
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.41569546
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.41569546
19positive regulation by organism of defense response of other organism involved in symbiotic interact4.41569546
20modulation by symbiont of host immune response (GO:0052553)4.41569546
21long-chain fatty acid biosynthetic process (GO:0042759)4.40594631
22long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.34009987
23myelin maintenance (GO:0043217)4.28821057
24immunoglobulin mediated immune response (GO:0016064)4.16476744
25isoprenoid biosynthetic process (GO:0008299)4.11734195
26creatine metabolic process (GO:0006600)4.08692701
27long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.05282665
28negative regulation of interleukin-12 production (GO:0032695)3.98088882
29regulation of mast cell degranulation (GO:0043304)3.90135261
30fatty-acyl-CoA biosynthetic process (GO:0046949)3.88759798
31positive regulation of oligodendrocyte differentiation (GO:0048714)3.77199118
32fatty-acyl-CoA metabolic process (GO:0035337)3.76805943
33detection of other organism (GO:0098543)3.75969726
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.74532451
35antigen processing and presentation of endogenous antigen (GO:0019883)3.68661557
36detection of bacterium (GO:0016045)3.66811689
37response to lipoprotein particle (GO:0055094)3.64240950
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.63634063
39negative regulation of erythrocyte differentiation (GO:0045647)3.62736647
40positive regulation of B cell differentiation (GO:0045579)3.59408028
41B cell mediated immunity (GO:0019724)3.53704062
42regulation of mast cell activation involved in immune response (GO:0033006)3.51097229
43negative regulation of cell killing (GO:0031342)3.51064377
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.51064377
45respiratory burst (GO:0045730)3.47642928
46macrophage activation involved in immune response (GO:0002281)3.43440186
47regulation of myeloid leukocyte mediated immunity (GO:0002886)3.40716676
48protein neddylation (GO:0045116)3.40690628
49adhesion of symbiont to host cell (GO:0044650)3.40473820
50virion attachment to host cell (GO:0019062)3.40473820
51regulation of collateral sprouting (GO:0048670)3.40299624
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.37122356
53acyl-CoA biosynthetic process (GO:0071616)3.36515091
54thioester biosynthetic process (GO:0035384)3.36515091
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.36443864
56regulation of leukocyte degranulation (GO:0043300)3.35754262
57regulation of superoxide anion generation (GO:0032928)3.30610545
58GPI anchor biosynthetic process (GO:0006506)3.28675754
59response to host immune response (GO:0052572)3.24019319
60response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.24019319
61positive regulation of mast cell activation (GO:0033005)3.23344883
62L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.20924317
63cellular extravasation (GO:0045123)3.18313595
64leukocyte aggregation (GO:0070486)3.16939931
65positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.16162824
66detection of external biotic stimulus (GO:0098581)3.16159689
67regulation of B cell receptor signaling pathway (GO:0050855)3.14392487
68myeloid cell activation involved in immune response (GO:0002275)3.12769079
69regulation of mast cell activation (GO:0033003)3.08087454
70response to methylmercury (GO:0051597)3.07656337
71regulation of lipoprotein metabolic process (GO:0050746)3.04332603
72lipopolysaccharide-mediated signaling pathway (GO:0031663)3.04125688
73very long-chain fatty acid metabolic process (GO:0000038)3.01007030
74Arp2/3 complex-mediated actin nucleation (GO:0034314)3.00975766
75positive regulation of mast cell degranulation (GO:0043306)3.00654254
76positive regulation of mast cell activation involved in immune response (GO:0033008)3.00654254
77mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.98923313
78substantia nigra development (GO:0021762)2.98726229
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.92873627
80membrane raft organization (GO:0031579)2.92615634
81glycosylceramide metabolic process (GO:0006677)2.92463215
82GPI anchor metabolic process (GO:0006505)2.89927875
83regulation of gamma-delta T cell activation (GO:0046643)2.87935454
84response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.87472839
85response to host (GO:0075136)2.87472839
86response to host defenses (GO:0052200)2.87472839
87response to redox state (GO:0051775)2.87243723
88glycerophospholipid catabolic process (GO:0046475)2.86872611
89signal peptide processing (GO:0006465)2.83326151
90regulation of interferon-beta biosynthetic process (GO:0045357)2.81135556
91aldehyde catabolic process (GO:0046185)2.80966853
92adhesion of symbiont to host (GO:0044406)2.80547506
93energy coupled proton transport, down electrochemical gradient (GO:0015985)2.80530623
94ATP synthesis coupled proton transport (GO:0015986)2.80530623
95positive regulation of pseudopodium assembly (GO:0031274)2.80461857
96detection of molecule of bacterial origin (GO:0032490)2.79530694
97neutrophil activation (GO:0042119)2.79274680
98regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.79133642
99regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.78887016
100positive regulation of antigen processing and presentation (GO:0002579)2.78171592
101import into cell (GO:0098657)2.78026717
102positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.76581667
103positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.74544260
104pinocytosis (GO:0006907)2.74450519
105regulation of B cell apoptotic process (GO:0002902)2.74345996
106positive regulation of interleukin-17 production (GO:0032740)2.74321391
107detection of biotic stimulus (GO:0009595)2.73970559
108nucleotide transmembrane transport (GO:1901679)2.73167298
109microglial cell activation (GO:0001774)2.72888921
110positive regulation of toll-like receptor signaling pathway (GO:0034123)2.72815917
111regulation of antigen processing and presentation (GO:0002577)2.71753240
112regulation of regulated secretory pathway (GO:1903305)2.71354179
113negative regulation of acute inflammatory response (GO:0002674)2.70839220
114negative regulation of chemokine production (GO:0032682)2.69931721
115negative regulation of phagocytosis (GO:0050765)2.69707947
116response to protozoan (GO:0001562)2.68419635
117defense response to protozoan (GO:0042832)2.68147205
118macrophage activation (GO:0042116)2.67485798
119amino sugar catabolic process (GO:0046348)2.67464648
120negative regulation of neurotransmitter secretion (GO:0046929)2.66899589
121cellular response to thyroid hormone stimulus (GO:0097067)2.66097333
122regulation of B cell differentiation (GO:0045577)2.65217123
123positive regulation of actin filament depolymerization (GO:0030836)2.65036728
124oligodendrocyte differentiation (GO:0048709)2.64603052
125triglyceride biosynthetic process (GO:0019432)2.64583786
126NIK/NF-kappaB signaling (GO:0038061)2.62179729
127heme transport (GO:0015886)2.61766543
128mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.61694832
129negative regulation of myeloid cell apoptotic process (GO:0033033)2.61099920
130regulation of metalloenzyme activity (GO:0048552)2.61056725
131membrane protein ectodomain proteolysis (GO:0006509)2.60401611
132astrocyte development (GO:0014002)2.59063845
133negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.58094149
134deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.57884165
135positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.57384284
136negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.57313049
137response to interferon-beta (GO:0035456)2.55536339
138negative regulation of innate immune response (GO:0045824)2.54887424
139granulocyte activation (GO:0036230)2.54386013
140negative regulation of cytokine production involved in immune response (GO:0002719)2.54037477
141low-density lipoprotein particle clearance (GO:0034383)2.53991093
142protoporphyrinogen IX metabolic process (GO:0046501)2.53719357
143peptidyl-cysteine modification (GO:0018198)2.53679941
144mature B cell differentiation involved in immune response (GO:0002313)2.53454452
145mannosylation (GO:0097502)2.53066275
146positive regulation of cellular amine metabolic process (GO:0033240)2.52740152
147protoporphyrinogen IX biosynthetic process (GO:0006782)2.52715536
148nuclear envelope reassembly (GO:0031468)2.52424684
149mitotic nuclear envelope reassembly (GO:0007084)2.52424684
150regulation of dendritic cell antigen processing and presentation (GO:0002604)2.52057927
151interferon-gamma-mediated signaling pathway (GO:0060333)2.51668960
152regulation of gamma-delta T cell differentiation (GO:0045586)2.50989454
153acyl-CoA metabolic process (GO:0006637)2.50513251
154thioester metabolic process (GO:0035383)2.50513251
155negative regulation of leukocyte mediated immunity (GO:0002704)2.50321069
156purine nucleotide salvage (GO:0032261)2.49711732
157preassembly of GPI anchor in ER membrane (GO:0016254)2.49551673
158glutathione derivative biosynthetic process (GO:1901687)2.47728164
159glutathione derivative metabolic process (GO:1901685)2.47728164
160tissue regeneration (GO:0042246)2.47562828
161heme metabolic process (GO:0042168)2.47479079
162L-methionine salvage (GO:0071267)2.47235367
163L-methionine biosynthetic process (GO:0071265)2.47235367
164amino acid salvage (GO:0043102)2.47235367
165alcohol biosynthetic process (GO:0046165)2.47052085
166positive regulation of leukocyte degranulation (GO:0043302)2.47045921
167negative regulation of B cell apoptotic process (GO:0002903)2.46765841
168heme biosynthetic process (GO:0006783)2.45956993
169positive regulation of monocyte chemotaxis (GO:0090026)2.45162193
170phagosome maturation (GO:0090382)2.44896383
171purine deoxyribonucleotide catabolic process (GO:0009155)2.44624226
172antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.44618494
173myeloid cell homeostasis (GO:0002262)2.43812035
174L-serine metabolic process (GO:0006563)2.43727013
175positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.43603481
176respiratory electron transport chain (GO:0022904)2.42657516
177acylglycerol biosynthetic process (GO:0046463)2.42482033
178neutral lipid biosynthetic process (GO:0046460)2.42482033
179phosphatidylserine acyl-chain remodeling (GO:0036150)2.41742578
180B cell receptor signaling pathway (GO:0050853)2.41637097
181antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.41147424
182response to muramyl dipeptide (GO:0032495)2.41051787
183regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.40952018
184ethanol metabolic process (GO:0006067)2.40730619
185regulation of pseudopodium assembly (GO:0031272)2.40417686
186positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.40192163
187superoxide anion generation (GO:0042554)2.39690691
188negative regulation of interleukin-6 production (GO:0032715)2.39159744
189leukocyte degranulation (GO:0043299)2.38979953
190lipoxygenase pathway (GO:0019372)2.38597184
191fatty acid biosynthetic process (GO:0006633)2.38461579
192response to thyroid hormone (GO:0097066)2.37629797
193negative regulation of lymphocyte mediated immunity (GO:0002707)2.37280039

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.30955550
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.67823760
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.22106955
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.19401653
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.95182530
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.92176587
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.75698952
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.73153077
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69477865
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.63248515
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.36136876
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33928664
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32464190
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.30465790
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.24331197
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24168494
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18198720
18* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16669983
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08638913
20MYC_22102868_ChIP-Seq_BL_Human2.00722690
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96588476
22IRF8_27001747_Chip-Seq_BMDM_Mouse1.94572471
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.93448165
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.88544438
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82945653
26* SPI1_23547873_ChIP-Seq_NB4_Human1.82448936
27PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.82178671
28* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.81264129
29* SPI1_23127762_ChIP-Seq_K562_Human1.80656044
30* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80574022
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79616770
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78838141
33MAF_26560356_Chip-Seq_TH1_Human1.73764356
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68121335
35UTX_26944678_Chip-Seq_JUKART_Human1.65872521
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.65740796
37E2F7_22180533_ChIP-Seq_HELA_Human1.64329782
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.60334444
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58213513
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.57578207
41VDR_21846776_ChIP-Seq_THP-1_Human1.56565981
42* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54432834
43* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52763062
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51973953
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50627434
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49936345
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.48812382
48VDR_24763502_ChIP-Seq_THP-1_Human1.47833768
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47605957
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47410096
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45751752
52LXR_22292898_ChIP-Seq_THP-1_Human1.41334408
53* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39440783
54VDR_23849224_ChIP-Seq_CD4+_Human1.38151719
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35991041
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.35790188
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35703523
58FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34188585
59* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33887644
60* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33842524
61MYB_26560356_Chip-Seq_TH1_Human1.33666371
62BCL6_27268052_Chip-Seq_Bcells_Human1.33121655
63* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32683379
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29018884
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27958906
66NCOR1_26117541_ChIP-Seq_K562_Human1.27506614
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26553231
68DCP1A_22483619_ChIP-Seq_HELA_Human1.26063074
69STAT1_20625510_ChIP-Seq_HELA_Human1.25867023
70* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25104628
71* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24826877
72* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24721747
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24569892
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24220614
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.22731995
76* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21787490
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21761541
78SCL_19346495_ChIP-Seq_HPC-7_Human1.21742919
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20288107
80* RUNX1_22412390_ChIP-Seq_EML_Mouse1.18943076
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15881815
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15482835
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14173625
84TCF7_22412390_ChIP-Seq_EML_Mouse1.13633434
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13494278
86STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10611544
87SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10185046
88XRN2_22483619_ChIP-Seq_HELA_Human1.09380131
89TFEB_21752829_ChIP-Seq_HELA_Human1.08887554
90* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08051859
91GATA1_19941826_ChIP-Seq_K562_Human1.06106383
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05953538
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04605401
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04229256
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04134729
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02670069
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02424678
98* P68_20966046_ChIP-Seq_HELA_Human1.02234658
99CIITA_25753668_ChIP-Seq_RAJI_Human1.01783051
100P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00322608
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00102221
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99635901
103MYC_18555785_ChIP-Seq_MESCs_Mouse0.99624536
104ELK1_19687146_ChIP-ChIP_HELA_Human0.98754495
105CTCF_26484167_Chip-Seq_Bcells_Mouse0.98572319
106* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98130762
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97952774
108CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97925016
109YY1_21170310_ChIP-Seq_MESCs_Mouse0.97419735
110SPI1_20517297_ChIP-Seq_HL60_Human0.97257224
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96887208
112* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96852323
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96759369
114BCOR_27268052_Chip-Seq_Bcells_Human0.95854903
115GATA1_22025678_ChIP-Seq_K562_Human0.95818239
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95506914
117GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95306049
118ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94404293
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.92599588
120MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90767474
121GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90289038
122PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90217131
123MYB_26560356_Chip-Seq_TH2_Human0.89884172
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89788319
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86738567
126EOMES_21245162_ChIP-Seq_HESCs_Human0.86491198
127FOXP3_21729870_ChIP-Seq_TREG_Human0.86326854
128SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86082839
129EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85851325
130CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84774177
131MAF_26560356_Chip-Seq_TH2_Human0.82787628
132* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82269085
133NANOG_20526341_ChIP-Seq_ESCs_Human0.81726251
134NELFA_20434984_ChIP-Seq_ESCs_Mouse0.81656755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.04686830
2MP0005058_abnormal_lysosome_morphology3.71440125
3MP0003950_abnormal_plasma_membrane3.37438100
4MP0003690_abnormal_glial_cell2.94701552
5MP0003656_abnormal_erythrocyte_physiolo2.66751271
6MP0009278_abnormal_bone_marrow2.64942155
7MP0003186_abnormal_redox_activity2.61300890
8MP0005397_hematopoietic_system_phenotyp2.58086457
9MP0001545_abnormal_hematopoietic_system2.58086457
10MP0009785_altered_susceptibility_to2.53376649
11MP0009840_abnormal_foam_cell2.39115371
12MP0006082_CNS_inflammation2.37714643
13MP0005451_abnormal_body_composition2.37278966
14MP0002419_abnormal_innate_immunity2.34210563
15MP0004147_increased_porphyrin_level2.31341560
16MP0002148_abnormal_hypersensitivity_rea2.22203982
17MP0001835_abnormal_antigen_presentation2.20964116
18MP0003436_decreased_susceptibility_to2.18380723
19MP0005025_abnormal_response_to2.17054485
20MP0003724_increased_susceptibility_to2.13665621
21MP0008260_abnormal_autophagy2.12092185
22MP0005000_abnormal_immune_tolerance2.04740085
23* MP0003806_abnormal_nucleotide_metabolis1.91034102
24MP0003329_amyloid_beta_deposits1.86150583
25MP0001529_abnormal_vocalization1.85018269
26MP0009764_decreased_sensitivity_to1.77132192
27MP0003191_abnormal_cellular_cholesterol1.74668107
28MP0003300_gastrointestinal_ulcer1.69758630
29MP0002396_abnormal_hematopoietic_system1.67409989
30MP0000604_amyloidosis1.67113730
31MP0009333_abnormal_splenocyte_physiolog1.63707186
32MP0003634_abnormal_glial_cell1.62356234
33MP0002723_abnormal_immune_serum1.56282832
34MP0000465_gastrointestinal_hemorrhage1.56088485
35MP0001905_abnormal_dopamine_level1.55865175
36MP0003136_yellow_coat_color1.55384659
37MP0000858_altered_metastatic_potential1.55243296
38MP0001661_extended_life_span1.54160690
39MP0003303_peritoneal_inflammation1.54077125
40MP0004185_abnormal_adipocyte_glucose1.53840752
41MP0000685_abnormal_immune_system1.53162311
42MP0002452_abnormal_antigen_presenting1.52386491
43MP0003172_abnormal_lysosome_physiology1.48417410
44MP0002420_abnormal_adaptive_immunity1.48392812
45MP0005387_immune_system_phenotype1.47618537
46MP0001790_abnormal_immune_system1.47618537
47MP0001819_abnormal_immune_cell1.47588455
48MP0002722_abnormal_immune_system1.46867666
49MP0004742_abnormal_vestibular_system1.44976035
50MP0005671_abnormal_response_to1.44498595
51MP0001533_abnormal_skeleton_physiology1.43819279
52MP0000343_altered_response_to1.42501794
53MP0003763_abnormal_thymus_physiology1.41571081
54MP0001851_eye_inflammation1.40650078
55MP0008438_abnormal_cutaneous_collagen1.36160541
56MP0004043_abnormal_pH_regulation1.33502132
57MP0010678_abnormal_skin_adnexa1.33460768
58MP0000383_abnormal_hair_follicle1.30803917
59MP0001800_abnormal_humoral_immune1.30588828
60MP0005464_abnormal_platelet_physiology1.30552866
61MP0001485_abnormal_pinna_reflex1.25677350
62MP0006036_abnormal_mitochondrial_physio1.25225822
63MP0003075_altered_response_to1.23939338
64MP0004381_abnormal_hair_follicle1.22520095
65MP0005171_absent_coat_pigmentation1.20768165
66MP0005408_hypopigmentation1.18860983
67MP0002405_respiratory_system_inflammati1.17132921
68MP0005584_abnormal_enzyme/coenzyme_acti1.16480772
69MP0002933_joint_inflammation1.16475910
70MP0001845_abnormal_inflammatory_respons1.16375559
71MP0008469_abnormal_protein_level1.15902123
72MP0004808_abnormal_hematopoietic_stem1.14922601
73MP0003828_pulmonary_edema1.14918377
74MP0008004_abnormal_stomach_pH1.10737445
75MP0000015_abnormal_ear_pigmentation1.09392609
76MP0003632_abnormal_nervous_system1.09115883
77MP0003453_abnormal_keratinocyte_physiol1.07171223
78MP0000462_abnormal_digestive_system1.06226745
79MP0000716_abnormal_immune_system1.05693736
80MP0003011_delayed_dark_adaptation1.03183827
81MP0005310_abnormal_salivary_gland1.03150460
82MP0002998_abnormal_bone_remodeling1.03077687
83MP0004142_abnormal_muscle_tone1.02698586
84MP0003195_calcinosis1.01124228
85MP0005166_decreased_susceptibility_to1.00926953
86MP0002139_abnormal_hepatobiliary_system1.00613836
87MP0010155_abnormal_intestine_physiology0.99782099
88MP0005164_abnormal_response_to0.98843139
89MP0000703_abnormal_thymus_morphology0.98294392
90MP0009765_abnormal_xenobiotic_induced0.97757675
91MP0002229_neurodegeneration0.97586967
92MP0004510_myositis0.96078873
93MP0004947_skin_inflammation0.95927951
94MP0005381_digestive/alimentary_phenotyp0.95865593
95MP0001727_abnormal_embryo_implantation0.93550330
96MP0008873_increased_physiological_sensi0.93295605
97MP0002019_abnormal_tumor_incidence0.92878209
98MP0002118_abnormal_lipid_homeostasis0.92876744
99MP0002429_abnormal_blood_cell0.92242209
100MP0004885_abnormal_endolymph0.91483847
101MP0005319_abnormal_enzyme/_coenzyme0.91419433
102MP0009643_abnormal_urine_homeostasis0.90875775
103MP0002277_abnormal_respiratory_mucosa0.90564587
104MP0005083_abnormal_biliary_tract0.90467679
105MP0001853_heart_inflammation0.89455232
106MP0001663_abnormal_digestive_system0.88827666
107MP0000689_abnormal_spleen_morphology0.87163894
108MP0009763_increased_sensitivity_to0.86614842
109MP0001666_abnormal_nutrient_absorption0.85635845
110MP0005165_increased_susceptibility_to0.85516784
111MP0002132_abnormal_respiratory_system0.85312549
112MP0001873_stomach_inflammation0.85246623
113MP0003448_altered_tumor_morphology0.84537081
114MP0004134_abnormal_chest_morphology0.84392160
115MP0005409_darkened_coat_color0.83776417
116MP0003183_abnormal_peptide_metabolism0.81456891
117MP0003866_abnormal_defecation0.81371783
118MP0002398_abnormal_bone_marrow0.80494174
119MP0005390_skeleton_phenotype0.79839081
120MP0004883_abnormal_blood_vessel0.79679158
121MP0006035_abnormal_mitochondrial_morpho0.77528419
122MP0000490_abnormal_crypts_of0.76445382
123MP0001764_abnormal_homeostasis0.74196402
124MP0005075_abnormal_melanosome_morpholog0.72736231
125MP0000372_irregular_coat_pigmentation0.72683586
126MP0005636_abnormal_mineral_homeostasis0.72658407
127MP0005332_abnormal_amino_acid0.70962023
128MP0002295_abnormal_pulmonary_circulatio0.70729356
129MP0000647_abnormal_sebaceous_gland0.70303476
130MP0000609_abnormal_liver_physiology0.70035161
131MP0000313_abnormal_cell_death0.69813727
132MP0002877_abnormal_melanocyte_morpholog0.69539910
133MP0008874_decreased_physiological_sensi0.65665753
134MP0003795_abnormal_bone_structure0.65359363
135MP0002254_reproductive_system_inflammat0.64566840
136MP0008007_abnormal_cellular_replicative0.59584225
137MP0005084_abnormal_gallbladder_morpholo0.59033098

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)4.57240895
2Increased serum pyruvate (HP:0003542)4.57240895
3Parakeratosis (HP:0001036)4.50337685
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.47530246
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.47530246
6Neurofibrillary tangles (HP:0002185)4.15647309
7Cerebral hypomyelination (HP:0006808)4.02117158
8Myositis (HP:0100614)4.00478018
9Abnormality of macrophages (HP:0004311)3.95434700
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.95370583
11Recurrent abscess formation (HP:0002722)3.81118627
12Vacuolated lymphocytes (HP:0001922)3.77009656
13Prolonged bleeding time (HP:0003010)3.59555193
14Mediastinal lymphadenopathy (HP:0100721)3.55765230
15Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.50775107
16Congenital ichthyosiform erythroderma (HP:0007431)3.45859488
17Orchitis (HP:0100796)3.35790513
18Recurrent bacterial skin infections (HP:0005406)3.33396860
19* Hepatosplenomegaly (HP:0001433)3.30957218
20Sensory axonal neuropathy (HP:0003390)3.28111599
21Axonal loss (HP:0003447)3.20108774
22Recurrent fungal infections (HP:0002841)3.15839697
23Increased neuronal autofluorescent lipopigment (HP:0002074)3.04222337
24Peripheral hypomyelination (HP:0007182)3.01433559
25Meningitis (HP:0001287)2.97967508
26Leukodystrophy (HP:0002415)2.97373814
27Epistaxis (HP:0000421)2.97267720
28Eczematoid dermatitis (HP:0000976)2.96494596
29Spastic paraparesis (HP:0002313)2.91470874
30Renal Fanconi syndrome (HP:0001994)2.88181432
31Retrobulbar optic neuritis (HP:0100654)2.84314805
32Optic neuritis (HP:0100653)2.84314805
33Hepatocellular necrosis (HP:0001404)2.83849727
34Cellulitis (HP:0100658)2.82715111
35Hypertensive crisis (HP:0100735)2.79036529
36Stridor (HP:0010307)2.78561188
37Increased cerebral lipofuscin (HP:0011813)2.76937049
38Hepatic necrosis (HP:0002605)2.71683086
39Abnormality of the corticospinal tract (HP:0002492)2.69045734
403-Methylglutaconic aciduria (HP:0003535)2.65485676
41Acute necrotizing encephalopathy (HP:0006965)2.65445123
42Abnormality of transition element cation homeostasis (HP:0011030)2.65053295
43Cerebral inclusion bodies (HP:0100314)2.62451181
44Mitochondrial inheritance (HP:0001427)2.62199981
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.59664490
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.56411027
47Recurrent viral infections (HP:0004429)2.55665574
48Encephalitis (HP:0002383)2.55422550
49Recurrent skin infections (HP:0001581)2.55346213
50Systemic lupus erythematosus (HP:0002725)2.54915434
51Cerebral hemorrhage (HP:0001342)2.54299021
52Segmental peripheral demyelination/remyelination (HP:0003481)2.53358303
53Increased IgM level (HP:0003496)2.52864861
54Spontaneous hematomas (HP:0007420)2.48091988
55Thrombocytosis (HP:0001894)2.46308911
56Acute encephalopathy (HP:0006846)2.46278125
57Gingivitis (HP:0000230)2.46069383
58Loss of speech (HP:0002371)2.42787513
59Increased IgE level (HP:0003212)2.42034238
60Obstructive lung disease (HP:0006536)2.41575886
61Chronic obstructive pulmonary disease (HP:0006510)2.41575886
62Onion bulb formation (HP:0003383)2.39857766
63Gastrointestinal infarctions (HP:0005244)2.39678782
64Elevated erythrocyte sedimentation rate (HP:0003565)2.38754214
65CNS hypomyelination (HP:0003429)2.36155774
66Stomatitis (HP:0010280)2.35961889
67Premature skin wrinkling (HP:0100678)2.35609426
68Chronic mucocutaneous candidiasis (HP:0002728)2.34436109
69Recurrent cutaneous fungal infections (HP:0011370)2.34436109
70Autoimmune thrombocytopenia (HP:0001973)2.33367437
71Petechiae (HP:0000967)2.31624089
72Gingival bleeding (HP:0000225)2.31523600
73Increased serum ferritin (HP:0003281)2.31418247
74Abnormal mitochondria in muscle tissue (HP:0008316)2.31074121
75Increased hepatocellular lipid droplets (HP:0006565)2.30136772
76Purpura (HP:0000979)2.29256378
77Prolonged neonatal jaundice (HP:0006579)2.27650303
78Abnormal auditory evoked potentials (HP:0006958)2.27101143
79Vasculitis (HP:0002633)2.26818189
80Lipid accumulation in hepatocytes (HP:0006561)2.24958958
81Panhypogammaglobulinemia (HP:0003139)2.24512586
82Ileus (HP:0002595)2.24237129
83Chest pain (HP:0100749)2.23433209
84Granulocytopenia (HP:0001913)2.20410963
85Anorexia (HP:0002039)2.19139983
86Recurrent gram-negative bacterial infections (HP:0005420)2.18526415
87Respiratory failure (HP:0002878)2.18340457
88Polycythemia (HP:0001901)2.18119325
89Hypochromic microcytic anemia (HP:0004840)2.17723065
90Progressive neurologic deterioration (HP:0002344)2.17452132
91Increased CSF lactate (HP:0002490)2.16853295
92Paralysis (HP:0003470)2.15730494
93Abnormal platelet volume (HP:0011876)2.14750640
94Abnormal gallbladder physiology (HP:0012438)2.13194157
95Cholecystitis (HP:0001082)2.13194157
96Chronic otitis media (HP:0000389)2.12721790
97Microcytic anemia (HP:0001935)2.12239645
98Postnatal microcephaly (HP:0005484)2.10493669
99Slow saccadic eye movements (HP:0000514)2.09818944
100Hypochromic anemia (HP:0001931)2.07875658
101Pustule (HP:0200039)2.07625041
102Keratoconjunctivitis sicca (HP:0001097)2.06795528
103Osteomyelitis (HP:0002754)2.06351452
104Pulmonary infiltrates (HP:0002113)2.05616122
105Dysostosis multiplex (HP:0000943)2.05612826
106Gastrointestinal inflammation (HP:0004386)2.05512956
107Autoamputation (HP:0001218)2.04989528
108Hypergammaglobulinemia (HP:0010702)2.04131403
109Ragged-red muscle fibers (HP:0003200)2.03763506
110Impaired platelet aggregation (HP:0003540)2.03200701
111Abnormal platelet function (HP:0011869)2.03200701
112Arterial thrombosis (HP:0004420)2.02796969
113Leukocytosis (HP:0001974)2.00611775
114Disinhibition (HP:0000734)2.00257143
115Increased muscle lipid content (HP:0009058)1.99355417
116Abnormality of liposaccharide metabolism (HP:0010968)1.98859523
117Abnormality of glycosphingolipid metabolism (HP:0004343)1.98859523
118Abnormality of glycolipid metabolism (HP:0010969)1.98859523
119Erythroderma (HP:0001019)1.97155747
120Paraparesis (HP:0002385)1.97091487
121Progressive macrocephaly (HP:0004481)1.96413835
122Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95375545
123Abnormality of polysaccharide metabolism (HP:0011012)1.95375545
124Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95375545
125Inflammation of the large intestine (HP:0002037)1.95301225
126Supranuclear gaze palsy (HP:0000605)1.93567430
127Hemoptysis (HP:0002105)1.92633410
128Patchy hypopigmentation of hair (HP:0011365)1.92376885
129Microvesicular hepatic steatosis (HP:0001414)1.90079217
130Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89871899
131Agammaglobulinemia (HP:0004432)1.89835297
132Exertional dyspnea (HP:0002875)1.88804790
133Morphological abnormality of the inner ear (HP:0011390)1.87921097
134Abnormality of T cell physiology (HP:0011840)1.87780171
135Splenomegaly (HP:0001744)1.87596402
136Methylmalonic acidemia (HP:0002912)1.87572347
137Abnormality of iron homeostasis (HP:0011031)1.87547930
138Abnormality of T cells (HP:0002843)1.86937534
139Increased intramyocellular lipid droplets (HP:0012240)1.86021441
140Abnormality of fatty-acid metabolism (HP:0004359)1.85883971
141Skin rash (HP:0000988)1.84087747
142Akinesia (HP:0002304)1.83676348
143Autoimmune hemolytic anemia (HP:0001890)1.83621474
144Urticaria (HP:0001025)1.83357828
145Keratoconjunctivitis (HP:0001096)1.83218935
146Amaurosis fugax (HP:0100576)1.82546751
147Skin ulcer (HP:0200042)1.82174185
148Myocardial infarction (HP:0001658)1.81991750
149Nausea (HP:0002018)1.81741396
150Acute hepatic failure (HP:0006554)1.80977947
151Abnormality of cells of the erythroid lineage (HP:0012130)1.80937546
152Upper motor neuron abnormality (HP:0002127)1.80549460
153Amyloidosis (HP:0011034)1.77567507
154Abnormality of renal resorption (HP:0011038)1.77489685
155Hypoplastic pelvis (HP:0008839)1.76514466
156Hypomagnesemia (HP:0002917)1.76402249
157Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75540374
158Metabolic alkalosis (HP:0200114)1.75351680
159Abnormality of the heme biosynthetic pathway (HP:0010472)1.75319414
160Poor head control (HP:0002421)1.75067066
161Peripheral demyelination (HP:0011096)1.74666201
162Abnormal number of erythroid precursors (HP:0012131)1.74595338
163Methylmalonic aciduria (HP:0012120)1.74191694
164Increased serum lactate (HP:0002151)1.73551542
165Episodic fever (HP:0001954)1.72901729
166Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71967467
167Dicarboxylic aciduria (HP:0003215)1.71967467
168Duplicated collecting system (HP:0000081)1.71622541
169Gastrointestinal stroma tumor (HP:0100723)1.70954269
170Hypokalemic alkalosis (HP:0001949)1.70833874

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.04712801
2PBK4.28295501
3EPHB14.19202668
4RIPK44.09696511
5OXSR13.48747829
6TESK23.40612706
7MST43.17465763
8MAP3K112.95971229
9MAP2K32.88302531
10VRK22.26297695
11MAPKAPK52.21786668
12MET2.17989733
13BLK2.13364743
14LIMK12.12508581
15CLK12.10899479
16TAOK22.02656433
17BCR1.99865239
18IRAK41.96882842
19MAP3K31.91950395
20BUB11.87099178
21NME21.84209871
22PKN11.83600418
23GRK61.76014533
24FGR1.73913960
25JAK31.68842093
26WNK41.66657649
27CDK191.66100628
28SMG11.65973810
29CSNK1G31.53923116
30TNK21.53124312
31TAOK11.52496829
32BCKDK1.46166315
33STK161.40423539
34MAP4K11.32578649
35MAP3K11.29551419
36EIF2AK11.27494367
37MAP2K21.27178987
38SCYL21.25295575
39STK101.22067043
40CSNK1A1L1.20893100
41BMPR21.20456258
42PIM21.20385978
43CSK1.15749068
44CSF1R1.12119991
45TRPM71.09479865
46TXK1.07059979
47CSNK1G11.06078731
48ROCK21.04048343
49EIF2AK31.02778009
50DYRK21.01867220
51ARAF1.01643755
52GRK71.01608020
53LRRK21.00335986
54BTK0.95580441
55TBK10.95504203
56STK40.95161366
57MARK30.87828831
58KIT0.87633771
59ABL20.85471926
60RPS6KA50.85457890
61MAP3K80.84883636
62JAK20.83858296
63TESK10.82383585
64TLK10.82268942
65PAK10.81930094
66BMX0.80804303
67UHMK10.79927320
68TGFBR20.78389921
69SIK30.77833466
70VRK10.75873212
71ITK0.74983823
72DAPK10.74060317
73TEC0.73340005
74CSNK1G20.72102817
75CAMK2B0.71828725
76PIM10.69046662
77NEK60.68794182
78CAMK2D0.67786006
79WNK10.66947538
80MAP3K50.66700595
81IKBKB0.65912614
82MAP3K130.65802792
83PRKCQ0.64674889
84LCK0.63097014
85TNIK0.62739470
86LYN0.62678225
87MST1R0.59797900
88KDR0.59277482
89ERN10.58053490
90TYK20.57318784
91TAOK30.57076908
92PDPK10.55886302
93ICK0.54763738
94ILK0.54476385
95FGFR20.53102838
96WEE10.51778515
97MAP3K140.51551882
98PRPF4B0.50942578
99MATK0.50121832
100PRKG20.49491808
101MAPKAPK20.46473581
102RAF10.45449539
103RPS6KC10.45405067
104RPS6KL10.45405067
105IKBKE0.44940396
106IRAK20.44377951
107CDK140.44152503
108CAMK2G0.44113692
109PDK20.43424960
110PRKCD0.42155132
111FES0.41944255
112PAK40.41782637
113ZAP700.40916624
114SYK0.39369433
115FYN0.39171421
116CCNB10.38919005
117NTRK10.38650080
118PRKD10.37969793
119GSK3A0.37491891
120PRKD20.37199469
121DAPK30.36569528
122IRAK30.36320371
123PDK10.35530332
124MAPKAPK30.35237478
125TRIB30.34156295
126RPS6KA60.33936025
127AURKA0.33052938
128NUAK10.32753067
129ALK0.32554104
130MOS0.32257251
131MAP2K60.32128391
132DYRK30.31883606
133IRAK10.31479173
134CDK150.31226240
135PIK3CG0.31110632
136MAP3K120.30996561
137PTK60.30778386
138CDK40.30649954
139HCK0.30639114
140CDK11A0.30575658
141ABL10.30323861
142PIK3CA0.29188012
143BMPR1B0.28484744
144GRK10.26138077

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.63455909
2Steroid biosynthesis_Homo sapiens_hsa001004.34625065
3Fatty acid elongation_Homo sapiens_hsa000624.02303390
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.81285861
5Proteasome_Homo sapiens_hsa030502.50013823
6Protein export_Homo sapiens_hsa030602.46946121
7Oxidative phosphorylation_Homo sapiens_hsa001902.45550746
8Osteoclast differentiation_Homo sapiens_hsa043802.39244309
9Sulfur metabolism_Homo sapiens_hsa009202.23278433
10Ether lipid metabolism_Homo sapiens_hsa005652.22338463
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14141235
12Antigen processing and presentation_Homo sapiens_hsa046121.96854822
13Vitamin B6 metabolism_Homo sapiens_hsa007501.93926345
14Parkinsons disease_Homo sapiens_hsa050121.93906553
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89762237
16Histidine metabolism_Homo sapiens_hsa003401.86816659
17Ribosome_Homo sapiens_hsa030101.86305977
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.86124419
19Glutathione metabolism_Homo sapiens_hsa004801.81034405
20Primary immunodeficiency_Homo sapiens_hsa053401.79764278
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.74816454
22Type I diabetes mellitus_Homo sapiens_hsa049401.72957210
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53601921
24Folate biosynthesis_Homo sapiens_hsa007901.53510262
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52816772
26Lysosome_Homo sapiens_hsa041421.48984212
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47769252
28B cell receptor signaling pathway_Homo sapiens_hsa046621.44732284
29Herpes simplex infection_Homo sapiens_hsa051681.44351984
30Alzheimers disease_Homo sapiens_hsa050101.43549657
31Sphingolipid metabolism_Homo sapiens_hsa006001.42156788
32Viral myocarditis_Homo sapiens_hsa054161.40832204
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39032212
34RNA polymerase_Homo sapiens_hsa030201.35743343
35Linoleic acid metabolism_Homo sapiens_hsa005911.35399422
36Base excision repair_Homo sapiens_hsa034101.34389184
37Influenza A_Homo sapiens_hsa051641.32018135
38Acute myeloid leukemia_Homo sapiens_hsa052211.31814242
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25854824
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24514330
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20038107
42Toxoplasmosis_Homo sapiens_hsa051451.17980160
43Propanoate metabolism_Homo sapiens_hsa006401.16388623
44Measles_Homo sapiens_hsa051621.15046047
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14277357
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13802755
47Arachidonic acid metabolism_Homo sapiens_hsa005901.10112068
48Fatty acid metabolism_Homo sapiens_hsa012121.08658495
49African trypanosomiasis_Homo sapiens_hsa051431.06597091
50Other glycan degradation_Homo sapiens_hsa005111.06453083
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.06035762
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05476987
53Arginine and proline metabolism_Homo sapiens_hsa003301.04548481
54Phagosome_Homo sapiens_hsa041451.01644222
55Huntingtons disease_Homo sapiens_hsa050161.01106514
56Peroxisome_Homo sapiens_hsa041461.00447002
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99746254
58Platelet activation_Homo sapiens_hsa046110.97674585
59TNF signaling pathway_Homo sapiens_hsa046680.96781910
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96664925
61Butanoate metabolism_Homo sapiens_hsa006500.96544296
62Epstein-Barr virus infection_Homo sapiens_hsa051690.96276412
63Staphylococcus aureus infection_Homo sapiens_hsa051500.95348278
64Chemokine signaling pathway_Homo sapiens_hsa040620.94070419
65DNA replication_Homo sapiens_hsa030300.94041106
66Apoptosis_Homo sapiens_hsa042100.93317812
67Galactose metabolism_Homo sapiens_hsa000520.93084288
68Malaria_Homo sapiens_hsa051440.91419097
69Rheumatoid arthritis_Homo sapiens_hsa053230.86924030
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85318194
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82714609
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82324687
73Fructose and mannose metabolism_Homo sapiens_hsa000510.79577702
74Leishmaniasis_Homo sapiens_hsa051400.79259146
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77668975
76Shigellosis_Homo sapiens_hsa051310.77116956
77Sulfur relay system_Homo sapiens_hsa041220.76209552
78Hepatitis B_Homo sapiens_hsa051610.75474526
79Pertussis_Homo sapiens_hsa051330.75045510
80* Metabolic pathways_Homo sapiens_hsa011000.72618178
81Pyruvate metabolism_Homo sapiens_hsa006200.71384580
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71000207
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.70808674
84Chemical carcinogenesis_Homo sapiens_hsa052040.69645690
85Asthma_Homo sapiens_hsa053100.69417241
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.68223163
87Caffeine metabolism_Homo sapiens_hsa002320.66180642
88Salmonella infection_Homo sapiens_hsa051320.65900419
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65516789
90Autoimmune thyroid disease_Homo sapiens_hsa053200.64083999
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63224862
92Graft-versus-host disease_Homo sapiens_hsa053320.63105534
93Hepatitis C_Homo sapiens_hsa051600.62874369
94beta-Alanine metabolism_Homo sapiens_hsa004100.62583956
95Mineral absorption_Homo sapiens_hsa049780.61627538
96Fat digestion and absorption_Homo sapiens_hsa049750.60994520
97Bladder cancer_Homo sapiens_hsa052190.60518507
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59913914
99Pyrimidine metabolism_Homo sapiens_hsa002400.57557197
100Mismatch repair_Homo sapiens_hsa034300.57134068
101Fatty acid degradation_Homo sapiens_hsa000710.55502162
102Viral carcinogenesis_Homo sapiens_hsa052030.55271684
103Homologous recombination_Homo sapiens_hsa034400.52651938
104Hematopoietic cell lineage_Homo sapiens_hsa046400.51352777
105Vitamin digestion and absorption_Homo sapiens_hsa049770.51039858
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.50113004
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49479996
108Vibrio cholerae infection_Homo sapiens_hsa051100.47552883
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47034130
110Allograft rejection_Homo sapiens_hsa053300.46418267
111Retinol metabolism_Homo sapiens_hsa008300.46103372
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46098966
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.45786880
114HTLV-I infection_Homo sapiens_hsa051660.45765299
115Pancreatic cancer_Homo sapiens_hsa052120.45738332
116* Pentose phosphate pathway_Homo sapiens_hsa000300.45637675
117Glycerolipid metabolism_Homo sapiens_hsa005610.45128852
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44635377
119Legionellosis_Homo sapiens_hsa051340.44548885
120Non-homologous end-joining_Homo sapiens_hsa034500.43892309
121T cell receptor signaling pathway_Homo sapiens_hsa046600.43777459
122Collecting duct acid secretion_Homo sapiens_hsa049660.41673051
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.41019848
124Regulation of autophagy_Homo sapiens_hsa041400.39105619
125Tuberculosis_Homo sapiens_hsa051520.38664264
126Non-small cell lung cancer_Homo sapiens_hsa052230.38088062
127Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37894065
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.37541636
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37103617
130Nucleotide excision repair_Homo sapiens_hsa034200.36770244
131Spliceosome_Homo sapiens_hsa030400.36648847
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36378893
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36355996
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35950410
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.35893031
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.35079779
137* Carbon metabolism_Homo sapiens_hsa012000.34837059
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.34762081
139Endocytosis_Homo sapiens_hsa041440.33787132
140Systemic lupus erythematosus_Homo sapiens_hsa053220.33705729
141Chronic myeloid leukemia_Homo sapiens_hsa052200.33703958
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33516653
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33406328
144Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32460368
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.32104816
146PPAR signaling pathway_Homo sapiens_hsa033200.31849333

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