TANGO6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.91795516
2rRNA catabolic process (GO:0016075)5.05109364
3fucose catabolic process (GO:0019317)4.68374931
4L-fucose metabolic process (GO:0042354)4.68374931
5L-fucose catabolic process (GO:0042355)4.68374931
6DNA unwinding involved in DNA replication (GO:0006268)4.65071660
7folic acid-containing compound biosynthetic process (GO:0009396)4.63222160
8nucleobase biosynthetic process (GO:0046112)4.59269784
9IMP biosynthetic process (GO:0006188)4.57931204
10meiotic chromosome segregation (GO:0045132)4.47471990
11maturation of SSU-rRNA (GO:0030490)4.39674044
12indole-containing compound catabolic process (GO:0042436)4.39593001
13indolalkylamine catabolic process (GO:0046218)4.39593001
14tryptophan catabolic process (GO:0006569)4.39593001
15kynurenine metabolic process (GO:0070189)4.34298749
16DNA replication initiation (GO:0006270)4.33431038
17nuclear pore organization (GO:0006999)4.29975057
18protein K11-linked deubiquitination (GO:0035871)4.21783161
19regulation of gene silencing by RNA (GO:0060966)4.15918886
20regulation of posttranscriptional gene silencing (GO:0060147)4.15918886
21regulation of gene silencing by miRNA (GO:0060964)4.15918886
22exogenous drug catabolic process (GO:0042738)4.15424274
23DNA strand elongation involved in DNA replication (GO:0006271)4.14266469
24ribosomal small subunit assembly (GO:0000028)4.14259975
25protein localization to kinetochore (GO:0034501)4.13219210
26mitotic nuclear envelope disassembly (GO:0007077)3.98920265
27IMP metabolic process (GO:0046040)3.96731220
28reciprocal DNA recombination (GO:0035825)3.96677258
29reciprocal meiotic recombination (GO:0007131)3.96677258
30organic cation transport (GO:0015695)3.92076352
31DNA strand elongation (GO:0022616)3.90959809
32drug catabolic process (GO:0042737)3.89529558
33nuclear pore complex assembly (GO:0051292)3.88487948
34DNA replication checkpoint (GO:0000076)3.87324302
35indolalkylamine metabolic process (GO:0006586)3.86507312
36pre-miRNA processing (GO:0031054)3.84133889
37regulation of hippo signaling (GO:0035330)3.82713624
38purine nucleobase biosynthetic process (GO:0009113)3.80336859
39formation of translation preinitiation complex (GO:0001731)3.78339382
40RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.76598704
41telomere maintenance via semi-conservative replication (GO:0032201)3.73776063
42oxidative demethylation (GO:0070989)3.72670567
43ribosomal large subunit biogenesis (GO:0042273)3.71651148
44tryptophan metabolic process (GO:0006568)3.69745818
45regulation of meiosis I (GO:0060631)3.65695213
46ribosome biogenesis (GO:0042254)3.65372197
47membrane disassembly (GO:0030397)3.64021143
48nuclear envelope disassembly (GO:0051081)3.64021143
49detection of light stimulus involved in visual perception (GO:0050908)3.63750191
50detection of light stimulus involved in sensory perception (GO:0050962)3.63750191
51DNA replication-dependent nucleosome organization (GO:0034723)3.62564258
52DNA replication-dependent nucleosome assembly (GO:0006335)3.62564258
53cornea development in camera-type eye (GO:0061303)3.60571482
54viral transcription (GO:0019083)3.58401898
55translational termination (GO:0006415)3.58216812
56DNA duplex unwinding (GO:0032508)3.58120630
57DNA geometric change (GO:0032392)3.57542059
58ribonucleoprotein complex biogenesis (GO:0022613)3.55905112
59negative regulation of telomere maintenance (GO:0032205)3.54871866
60mitotic metaphase plate congression (GO:0007080)3.54778794
61histone-serine phosphorylation (GO:0035404)3.49622404
62ribosomal small subunit biogenesis (GO:0042274)3.44523986
63ncRNA catabolic process (GO:0034661)3.42398315
64heterochromatin organization (GO:0070828)3.40331500
65translational elongation (GO:0006414)3.36266542
66mitochondrial DNA replication (GO:0006264)3.36152258
67mitochondrial DNA metabolic process (GO:0032042)3.34170108
68detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.33574592
69regulation of translational fidelity (GO:0006450)3.33367732
70ribosome assembly (GO:0042255)3.32775866
71protein localization to chromosome, centromeric region (GO:0071459)3.32567152
72telomere maintenance via recombination (GO:0000722)3.30593878
73cellular ketone body metabolic process (GO:0046950)3.29873409
74neural tube formation (GO:0001841)3.28224992
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26956414
76translational initiation (GO:0006413)3.24731948
77synapsis (GO:0007129)3.22511351
78mitotic recombination (GO:0006312)3.22354251
79metaphase plate congression (GO:0051310)3.21900591
80sulfation (GO:0051923)3.21346817
81replication fork processing (GO:0031297)3.20857110
82ketone body metabolic process (GO:1902224)3.20573575
83protein polyglutamylation (GO:0018095)3.18848214
84telomere maintenance via telomere lengthening (GO:0010833)3.18562275
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.16920458
86chromatin remodeling at centromere (GO:0031055)3.16363689
87nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.16134340
88positive regulation of meiosis (GO:0045836)3.15734000
89coenzyme catabolic process (GO:0009109)3.14994032
90C4-dicarboxylate transport (GO:0015740)3.14648344
91drug transmembrane transport (GO:0006855)3.14093932
92response to pheromone (GO:0019236)3.13791315
93resolution of meiotic recombination intermediates (GO:0000712)3.12648423
94maturation of 5.8S rRNA (GO:0000460)3.12015406
95snRNA metabolic process (GO:0016073)3.10832057
96snRNA processing (GO:0016180)3.09025868
97mitochondrial RNA metabolic process (GO:0000959)3.08305820
98dopamine transport (GO:0015872)3.03994390
99nucleoside salvage (GO:0043174)3.02451741
100rRNA processing (GO:0006364)3.02228200
101pore complex assembly (GO:0046931)3.01780587
102protein K6-linked ubiquitination (GO:0085020)3.01642312
103spliceosomal snRNP assembly (GO:0000387)3.01509345
104regulation of translation, ncRNA-mediated (GO:0045974)3.00730651
105negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.00730651
106negative regulation of translation, ncRNA-mediated (GO:0040033)3.00730651
107CENP-A containing nucleosome assembly (GO:0034080)3.00698163
108tetrahydrofolate metabolic process (GO:0046653)2.98827421
109regulation of nuclear cell cycle DNA replication (GO:0033262)2.98658042
110fucosylation (GO:0036065)2.96681844
111somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96592694
112somatic hypermutation of immunoglobulin genes (GO:0016446)2.96592694
113aromatic amino acid family catabolic process (GO:0009074)2.96408934
114negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.95928157
115regulation of hexokinase activity (GO:1903299)2.95788504
116regulation of glucokinase activity (GO:0033131)2.95788504
117water-soluble vitamin biosynthetic process (GO:0042364)2.95697323
118piRNA metabolic process (GO:0034587)2.95374215
119nucleotide-excision repair, DNA gap filling (GO:0006297)2.95340690
120negative regulation of reactive oxygen species metabolic process (GO:2000378)2.93990760
121rRNA metabolic process (GO:0016072)2.93431197
122negative regulation of mast cell activation (GO:0033004)2.93404449
123kidney morphogenesis (GO:0060993)2.92763139
124positive regulation of defense response to virus by host (GO:0002230)2.92450087
125UDP-N-acetylglucosamine metabolic process (GO:0006047)2.92159322
126cAMP catabolic process (GO:0006198)2.92000534
127folic acid metabolic process (GO:0046655)2.91926238
128paraxial mesoderm development (GO:0048339)2.90464877
129ubiquinone biosynthetic process (GO:0006744)2.90256002
130positive regulation of meiotic cell cycle (GO:0051446)2.89538303
131mitotic sister chromatid segregation (GO:0000070)2.88574226
132regulation of spindle organization (GO:0090224)2.87819349
133regulation of telomere maintenance (GO:0032204)2.87660054
134DNA replication-independent nucleosome assembly (GO:0006336)2.85019557
135DNA replication-independent nucleosome organization (GO:0034724)2.85019557
136gamma-aminobutyric acid transport (GO:0015812)2.84261750
137regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.81019036
138positive regulation of chromosome segregation (GO:0051984)2.80031950
139DNA deamination (GO:0045006)2.78935392
140DNA conformation change (GO:0071103)2.78600698
141activated T cell proliferation (GO:0050798)2.78054968
142RNA splicing, via transesterification reactions (GO:0000375)2.77939806
143SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.77517511
144telomere organization (GO:0032200)2.77075419
145replicative senescence (GO:0090399)2.76926126
146establishment of chromosome localization (GO:0051303)2.76578738
147RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.76522063
148mRNA splicing, via spliceosome (GO:0000398)2.76522063
149histone H3-K9 methylation (GO:0051567)2.75480541
150pyrimidine-containing compound salvage (GO:0008655)2.75049417
151pyrimidine nucleoside salvage (GO:0043097)2.75049417
152telomere maintenance (GO:0000723)2.74775352
153glycine metabolic process (GO:0006544)2.74512827
154pteridine-containing compound biosynthetic process (GO:0042559)2.73665675
155spliceosomal tri-snRNP complex assembly (GO:0000244)2.73416408
156chromatin assembly or disassembly (GO:0006333)2.73050148
157pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.72698761
158cellular protein complex disassembly (GO:0043624)2.72641555
159spliceosomal complex assembly (GO:0000245)2.72349642
160chromatin assembly (GO:0031497)2.71733172
161nuclear envelope organization (GO:0006998)2.71595245
162viral life cycle (GO:0019058)2.70177944
163detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.69577075
164neurotransmitter metabolic process (GO:0042133)2.69431313
165mitotic chromosome condensation (GO:0007076)2.69040971
166double-strand break repair via homologous recombination (GO:0000724)2.68742203
167kinetochore organization (GO:0051383)2.68676706
168protein targeting to ER (GO:0045047)2.68601852
169negative regulation of mRNA processing (GO:0050686)2.68113971
170recombinational repair (GO:0000725)2.68055076
171regulation of centrosome cycle (GO:0046605)2.67438337
172pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.67205494
173amine catabolic process (GO:0009310)2.65012767
174cellular biogenic amine catabolic process (GO:0042402)2.65012767
175macroautophagy (GO:0016236)2.63757954
176negative regulation of transcription regulatory region DNA binding (GO:2000678)2.62705815
177methionine biosynthetic process (GO:0009086)2.61787619
178DNA methylation involved in gamete generation (GO:0043046)2.59804191
179indole-containing compound metabolic process (GO:0042430)2.59635010
180reflex (GO:0060004)2.58781154
181aromatic amino acid family metabolic process (GO:0009072)2.57999654
182ubiquinone metabolic process (GO:0006743)2.55896533
183protein K63-linked deubiquitination (GO:0070536)2.54388909
184quaternary ammonium group transport (GO:0015697)2.53305864
185positive regulation of fatty acid oxidation (GO:0046321)2.52857433
186regulation of action potential (GO:0098900)2.42908267
187DNA double-strand break processing (GO:0000729)2.42385320
188cyclic nucleotide catabolic process (GO:0009214)2.40869969
189L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.39577894
190cellular response to exogenous dsRNA (GO:0071360)2.37082034
191adaptation of signaling pathway (GO:0023058)2.35555226
192L-methionine biosynthetic process (GO:0071265)2.34667912

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.73958598
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.11954220
3ZNF274_21170338_ChIP-Seq_K562_Hela3.98124186
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.77004211
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39819351
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.31242874
7GBX2_23144817_ChIP-Seq_PC3_Human3.06727727
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98052690
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79984437
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78134236
11VDR_22108803_ChIP-Seq_LS180_Human2.71246694
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70495888
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63485273
14IGF1R_20145208_ChIP-Seq_DFB_Human2.49058064
15EZH2_22144423_ChIP-Seq_EOC_Human2.44125911
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.37625815
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35255358
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35062097
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.34629479
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30318475
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.25891255
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24728490
23XRN2_22483619_ChIP-Seq_HELA_Human2.18524431
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17989151
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16113779
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13094249
27EWS_26573619_Chip-Seq_HEK293_Human2.12024317
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10784442
29CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10635446
30IRF1_19129219_ChIP-ChIP_H3396_Human2.09379224
31EGR1_19374776_ChIP-ChIP_THP-1_Human2.09340534
32FUS_26573619_Chip-Seq_HEK293_Human2.07112607
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06944686
34POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02510726
35MYC_22102868_ChIP-Seq_BL_Human1.99486689
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.98462946
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98290227
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97732345
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94601242
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.94056616
41ER_23166858_ChIP-Seq_MCF-7_Human1.91513781
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91432716
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90219629
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89181835
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.88658350
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88391137
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82850337
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82206818
49AR_21909140_ChIP-Seq_LNCAP_Human1.81934357
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79053112
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78815094
52CBP_20019798_ChIP-Seq_JUKART_Human1.78573714
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.78573714
54KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.78215260
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.78215260
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.78215260
57VDR_23849224_ChIP-Seq_CD4+_Human1.77423833
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75870635
59P300_19829295_ChIP-Seq_ESCs_Human1.75000997
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73332177
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73203813
62FOXP3_21729870_ChIP-Seq_TREG_Human1.72799602
63* CIITA_25753668_ChIP-Seq_RAJI_Human1.72746616
64STAT3_23295773_ChIP-Seq_U87_Human1.72140391
65TAF15_26573619_Chip-Seq_HEK293_Human1.71972480
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.68320596
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.67931148
68TTF2_22483619_ChIP-Seq_HELA_Human1.66228713
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64502968
70DCP1A_22483619_ChIP-Seq_HELA_Human1.64335861
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61716728
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60767990
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60616003
74TCF4_23295773_ChIP-Seq_U87_Human1.57560449
75GABP_19822575_ChIP-Seq_HepG2_Human1.53104850
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.52902334
77BCAT_22108803_ChIP-Seq_LS180_Human1.51895578
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50691459
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49838604
80TP53_22573176_ChIP-Seq_HFKS_Human1.49171642
81SMAD4_21799915_ChIP-Seq_A2780_Human1.47865728
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47330592
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47199811
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46991756
85MYC_18940864_ChIP-ChIP_HL60_Human1.45243703
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44887047
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44441692
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43401599
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38184089
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37472696
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37255326
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36396757
93AR_21572438_ChIP-Seq_LNCaP_Human1.35495950
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33340563
95TP63_19390658_ChIP-ChIP_HaCaT_Human1.32040685
96KDM5A_27292631_Chip-Seq_BREAST_Human1.29543268
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29430360
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29401616
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28023774
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.27797774
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27410069
102AR_25329375_ChIP-Seq_VCAP_Human1.26626418
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.24249918
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23960863
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23848943
106RUNX2_22187159_ChIP-Seq_PCA_Human1.23738559
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23596231
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23294385
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23294385
110EZH2_27294783_Chip-Seq_NPCs_Mouse1.23072078
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22835771
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21861595
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21552097
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21315312
115ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21028307
116SOX2_19829295_ChIP-Seq_ESCs_Human1.20458238
117NANOG_19829295_ChIP-Seq_ESCs_Human1.20458238
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20444376
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20047016
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20002958
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19455172
122TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19232699
123TCF4_22108803_ChIP-Seq_LS180_Human1.19112868
124ELK1_19687146_ChIP-ChIP_HELA_Human1.18468627
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16969795
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16826361
127KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16475375
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15903231
129RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15673692
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15130296
131PRDM14_20953172_ChIP-Seq_ESCs_Human1.14811006
132TP53_16413492_ChIP-PET_HCT116_Human1.14465930
133NOTCH1_21737748_ChIP-Seq_TLL_Human1.14332945
134VDR_21846776_ChIP-Seq_THP-1_Human1.12767152
135SMAD4_21741376_ChIP-Seq_EPCs_Human1.11474176
136NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11341157
137FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11327287
138PIAS1_25552417_ChIP-Seq_VCAP_Human1.10826656
139FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10245076
140TFEB_21752829_ChIP-Seq_HELA_Human1.09940089
141ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09362235
142SRF_21415370_ChIP-Seq_HL-1_Mouse1.08850166
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08566431
144KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08169456
145FLI1_21867929_ChIP-Seq_TH2_Mouse1.07015734
146AR_20517297_ChIP-Seq_VCAP_Human1.06977611
147SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06612629
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06211128
149HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05416098
150FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02934673
151FOXA1_25329375_ChIP-Seq_VCAP_Human1.02934673
152STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02672364
153ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02620249
154ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02162532
155HOXB7_26014856_ChIP-Seq_BT474_Human1.01941553
156GATA3_21878914_ChIP-Seq_MCF-7_Human1.01911867
157FOXH1_21741376_ChIP-Seq_EPCs_Human1.01587270
158GATA3_26560356_Chip-Seq_TH2_Human1.00941949
159SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00921081
160PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00565631
161CRX_20693478_ChIP-Seq_RETINA_Mouse1.00559569
162ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99254438
163NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99066558
164NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98651144
165JUN_21703547_ChIP-Seq_K562_Human0.98313124
166CDX2_22108803_ChIP-Seq_LS180_Human0.98308328
167E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97992851
168NANOG_20526341_ChIP-Seq_ESCs_Human0.97962683
169MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97527312
170NANOG_18555785_Chip-Seq_ESCs_Mouse0.97352959
171BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97336099
172CBX2_27304074_Chip-Seq_ESCs_Mouse0.96609043
173SMAD3_21741376_ChIP-Seq_EPCs_Human0.96511709
174AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96048878
175PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94912485
176TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94612849
177NCOR_22424771_ChIP-Seq_293T_Human0.93586673
178CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92126262
179SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89099510
180FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88976896
181NANOG_21062744_ChIP-ChIP_HESCs_Human0.88642617
182CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86957452
183NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86894846
184CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86627048
185TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85994349
186OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83945134
187CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83813713
188HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83511191
189TP63_17297297_ChIP-ChIP_HaCaT_Human0.82282486
190NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82151799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.06128137
2MP0010094_abnormal_chromosome_stability4.04674153
3MP0004957_abnormal_blastocyst_morpholog3.83367960
4MP0003111_abnormal_nucleus_morphology3.69371211
5MP0003693_abnormal_embryo_hatching3.66529194
6MP0003077_abnormal_cell_cycle3.24810066
7MP0008057_abnormal_DNA_replication3.17178494
8MP0003787_abnormal_imprinting2.85865698
9MP0003136_yellow_coat_color2.77518726
10MP0002837_dystrophic_cardiac_calcinosis2.64611487
11MP0003195_calcinosis2.56277598
12MP0008058_abnormal_DNA_repair2.44184013
13MP0003806_abnormal_nucleotide_metabolis2.42714522
14MP0010352_gastrointestinal_tract_polyps2.36668895
15MP0008875_abnormal_xenobiotic_pharmacok2.31604908
16MP0001730_embryonic_growth_arrest2.27730329
17MP0008007_abnormal_cellular_replicative2.23586627
18MP0002876_abnormal_thyroid_physiology2.23308673
19MP0002102_abnormal_ear_morphology2.20316233
20MP0002396_abnormal_hematopoietic_system2.20315813
21MP0005551_abnormal_eye_electrophysiolog2.19061356
22MP0000350_abnormal_cell_proliferation2.16762452
23MP0008932_abnormal_embryonic_tissue2.12898210
24MP0010030_abnormal_orbit_morphology2.09889572
25MP0000372_irregular_coat_pigmentation2.08602399
26MP0006292_abnormal_olfactory_placode2.03317833
27MP0002160_abnormal_reproductive_system2.00524517
28MP0002163_abnormal_gland_morphology1.98099155
29MP0005380_embryogenesis_phenotype1.95520912
30MP0001672_abnormal_embryogenesis/_devel1.95520912
31MP0005174_abnormal_tail_pigmentation1.88682571
32MP0003984_embryonic_growth_retardation1.87996508
33MP0002088_abnormal_embryonic_growth/wei1.86181235
34MP0005085_abnormal_gallbladder_physiolo1.81674064
35MP0003567_abnormal_fetal_cardiomyocyte1.73484726
36MP0000427_abnormal_hair_cycle1.70842431
37MP0005389_reproductive_system_phenotype1.70701119
38MP0002138_abnormal_hepatobiliary_system1.70196842
39MP0004145_abnormal_muscle_electrophysio1.69663542
40MP0005645_abnormal_hypothalamus_physiol1.68992342
41MP0001697_abnormal_embryo_size1.68815769
42MP0001968_abnormal_touch/_nociception1.67244505
43MP0003123_paternal_imprinting1.64783394
44MP0000015_abnormal_ear_pigmentation1.64643977
45MP0002080_prenatal_lethality1.63196454
46MP0008872_abnormal_physiological_respon1.62925265
47MP0003705_abnormal_hypodermis_morpholog1.58283271
48MP0002086_abnormal_extraembryonic_tissu1.57351259
49MP0002085_abnormal_embryonic_tissue1.55506700
50MP0003252_abnormal_bile_duct1.55022358
51MP0010307_abnormal_tumor_latency1.53724961
52MP0004197_abnormal_fetal_growth/weight/1.53511537
53MP0004142_abnormal_muscle_tone1.53130339
54MP0003566_abnormal_cell_adhesion1.51641731
55MP0004233_abnormal_muscle_weight1.51560881
56MP0001986_abnormal_taste_sensitivity1.49024787
57MP0004808_abnormal_hematopoietic_stem1.48378360
58MP0002084_abnormal_developmental_patter1.46947817
59MP0009745_abnormal_behavioral_response1.46444707
60MP0005076_abnormal_cell_differentiation1.45209762
61MP0009840_abnormal_foam_cell1.43509827
62MP0001919_abnormal_reproductive_system1.42358783
63MP0002653_abnormal_ependyma_morphology1.42343154
64MP0003941_abnormal_skin_development1.42219276
65MP0009046_muscle_twitch1.40734137
66MP0008877_abnormal_DNA_methylation1.35379509
67MP0005253_abnormal_eye_physiology1.34440051
68MP0005023_abnormal_wound_healing1.31507546
69MP0004130_abnormal_muscle_cell1.31309874
70MP0002928_abnormal_bile_duct1.31059145
71MP0003786_premature_aging1.29208876
72MP0005187_abnormal_penis_morphology1.28797403
73MP0002234_abnormal_pharynx_morphology1.28219114
74MP0005410_abnormal_fertilization1.27816814
75MP0003656_abnormal_erythrocyte_physiolo1.25913901
76MP0005360_urolithiasis1.25471721
77MP0004043_abnormal_pH_regulation1.25237070
78MP0002095_abnormal_skin_pigmentation1.24524662
79MP0010630_abnormal_cardiac_muscle1.23360652
80MP0000313_abnormal_cell_death1.21896019
81MP0009697_abnormal_copulation1.21581282
82MP0004084_abnormal_cardiac_muscle1.21315059
83MP0003221_abnormal_cardiomyocyte_apopto1.20920069
84MP0001501_abnormal_sleep_pattern1.19370222
85MP0001915_intracranial_hemorrhage1.19262919
86MP0006035_abnormal_mitochondrial_morpho1.18608806
87MP0005075_abnormal_melanosome_morpholog1.17416015
88MP0002938_white_spotting1.17190180
89MP0004381_abnormal_hair_follicle1.15880085
90MP0008775_abnormal_heart_ventricle1.15534883
91MP0001984_abnormal_olfaction1.15457830
92MP0002736_abnormal_nociception_after1.15028475
93MP0000490_abnormal_crypts_of1.14507246
94MP0001661_extended_life_span1.14447690
95MP0002019_abnormal_tumor_incidence1.13414506
96MP0002132_abnormal_respiratory_system1.12088520
97MP0001764_abnormal_homeostasis1.12036710
98MP0003646_muscle_fatigue1.11419351
99MP0005646_abnormal_pituitary_gland1.09915784
100MP0005379_endocrine/exocrine_gland_phen1.09302252
101MP0002272_abnormal_nervous_system1.07393818
102MP0009672_abnormal_birth_weight1.07209373
103MP0003698_abnormal_male_reproductive1.06969998
104MP0003011_delayed_dark_adaptation1.06851134
105MP0005171_absent_coat_pigmentation1.02587687
106MP0006276_abnormal_autonomic_nervous1.02574323
107MP0002269_muscular_atrophy1.01612889
108MP0001929_abnormal_gametogenesis1.00909221
109MP0004885_abnormal_endolymph1.00496897
110MP0002638_abnormal_pupillary_reflex0.99988944
111MP0001485_abnormal_pinna_reflex0.99287908
112MP0001849_ear_inflammation0.99171768
113MP0001293_anophthalmia0.99039571
114MP0004133_heterotaxia0.97408972
115MP0005167_abnormal_blood-brain_barrier0.97150825
116MP0006072_abnormal_retinal_apoptosis0.97145568
117MP0005266_abnormal_metabolism0.96628931
118MP0000703_abnormal_thymus_morphology0.95686320
119MP0005397_hematopoietic_system_phenotyp0.95215287
120MP0001545_abnormal_hematopoietic_system0.95215287
121MP0000631_abnormal_neuroendocrine_gland0.94479388
122MP0002733_abnormal_thermal_nociception0.93091876
123MP0000428_abnormal_craniofacial_morphol0.91390614
124MP0003186_abnormal_redox_activity0.91329129
125MP0005386_behavior/neurological_phenoty0.91198320
126MP0004924_abnormal_behavior0.91198320
127MP0003121_genomic_imprinting0.89375766
128MP0004087_abnormal_muscle_fiber0.89345561
129MP0005195_abnormal_posterior_eye0.89111501
130MP0010386_abnormal_urinary_bladder0.88038043
131MP0009053_abnormal_anal_canal0.87777299
132MP0009333_abnormal_splenocyte_physiolog0.87001815
133MP0003279_aneurysm0.86775374
134MP0000358_abnormal_cell_content/0.86740021
135MP0000750_abnormal_muscle_regeneration0.86629455
136MP0002111_abnormal_tail_morphology0.85144109
137MP0001324_abnormal_eye_pigmentation0.85028169
138MP0003828_pulmonary_edema0.84518324
139MP0000266_abnormal_heart_morphology0.84292130
140MP0005365_abnormal_bile_salt0.83080974
141MP0005310_abnormal_salivary_gland0.83026123
142MP0006036_abnormal_mitochondrial_physio0.82513499
143MP0004742_abnormal_vestibular_system0.82380653
144MP0002925_abnormal_cardiovascular_devel0.81802281
145MP0005332_abnormal_amino_acid0.80954411
146MP0004134_abnormal_chest_morphology0.80929787
147MP0000230_abnormal_systemic_arterial0.79011025
148MP0002693_abnormal_pancreas_physiology0.78696929
149MP0003718_maternal_effect0.78564994
150MP0009703_decreased_birth_body0.78294118
151MP0005395_other_phenotype0.77204891
152MP0003119_abnormal_digestive_system0.76623299
153MP0002557_abnormal_social/conspecific_i0.76332814
154MP0002722_abnormal_immune_system0.76017262
155MP0003763_abnormal_thymus_physiology0.75926402
156MP0002067_abnormal_sensory_capabilities0.75372522
157MP0005330_cardiomyopathy0.73639595
158MP0009278_abnormal_bone_marrow0.73162885
159MP0004484_altered_response_of0.72554897
160MP0000749_muscle_degeneration0.72250299
161MP0002127_abnormal_cardiovascular_syste0.71802992
162MP0010329_abnormal_lipoprotein_level0.70079501
163MP0000371_diluted_coat_color0.69752803
164MP0001970_abnormal_pain_threshold0.69625849
165MP0000733_abnormal_muscle_development0.69418767
166MP0000653_abnormal_sex_gland0.69319689
167MP0005376_homeostasis/metabolism_phenot0.67909557
168MP0000858_altered_metastatic_potential0.67873079
169MP0005384_cellular_phenotype0.67660401
170MP0002092_abnormal_eye_morphology0.66656211
171MP0005621_abnormal_cell_physiology0.66357688
172MP0003890_abnormal_embryonic-extraembry0.65422597
173MP0006138_congestive_heart_failure0.64558839
174MP0000689_abnormal_spleen_morphology0.63117637
175MP0005385_cardiovascular_system_phenoty0.62593693
176MP0001544_abnormal_cardiovascular_syste0.62593693
177MP0002398_abnormal_bone_marrow0.62245787
178MP0002210_abnormal_sex_determination0.62034768
179MP0008770_decreased_survivor_rate0.61180375
180MP0002128_abnormal_blood_circulation0.60117578
181MP0005623_abnormal_meninges_morphology0.59935164
182MP0003937_abnormal_limbs/digits/tail_de0.59526084
183MP0000598_abnormal_liver_morphology0.58663403
184MP0001286_abnormal_eye_development0.58387139
185MP0004036_abnormal_muscle_relaxation0.58019942

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.27971242
2Reticulocytopenia (HP:0001896)4.10144141
3Congenital stationary night blindness (HP:0007642)3.96839661
4Pancreatic cysts (HP:0001737)3.90062999
5Pancreatic fibrosis (HP:0100732)3.67449063
6Abnormality of midbrain morphology (HP:0002418)3.66030262
7Molar tooth sign on MRI (HP:0002419)3.66030262
8Selective tooth agenesis (HP:0001592)3.64396809
9Inability to walk (HP:0002540)3.55913476
10Chronic hepatic failure (HP:0100626)3.55839288
11Progressive inability to walk (HP:0002505)3.55599535
12Lissencephaly (HP:0001339)3.45861158
13Ragged-red muscle fibers (HP:0003200)3.38603096
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.35853221
15Abnormality of the renal cortex (HP:0011035)3.35109337
16Aplasia/Hypoplasia of the fovea (HP:0008060)3.34022088
17Hypoplasia of the fovea (HP:0007750)3.34022088
18Cerebellar dysplasia (HP:0007033)3.32704368
19Hyperventilation (HP:0002883)3.32580341
20Chromsome breakage (HP:0040012)3.30197787
21Ependymoma (HP:0002888)3.29767704
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.24786898
23Abnormality of alanine metabolism (HP:0010916)3.24786898
24Hyperalaninemia (HP:0003348)3.24786898
25Protruding tongue (HP:0010808)3.23821595
26Attenuation of retinal blood vessels (HP:0007843)3.22084778
27True hermaphroditism (HP:0010459)3.21144288
28Abnormality of cells of the erythroid lineage (HP:0012130)3.14477807
29Abnormal rod and cone electroretinograms (HP:0008323)3.14445982
30Abnormal biliary tract physiology (HP:0012439)3.12782813
31Bile duct proliferation (HP:0001408)3.12782813
32Birth length less than 3rd percentile (HP:0003561)3.11676075
33Nephronophthisis (HP:0000090)3.04888490
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98432646
35Colon cancer (HP:0003003)2.97392709
36Tubular atrophy (HP:0000092)2.95570194
37Clumsiness (HP:0002312)2.93486957
38Abnormal number of erythroid precursors (HP:0012131)2.89078173
39Medulloblastoma (HP:0002885)2.85318453
40Pallor (HP:0000980)2.83142185
41Multiple enchondromatosis (HP:0005701)2.77182774
42Abnormality of the renal medulla (HP:0100957)2.72299450
43Abnormality of the pons (HP:0007361)2.70705375
44Pseudobulbar signs (HP:0002200)2.68626483
45Rhabdomyosarcoma (HP:0002859)2.68032220
46Degeneration of anterior horn cells (HP:0002398)2.65320791
47Abnormality of the anterior horn cell (HP:0006802)2.65320791
48Breast hypoplasia (HP:0003187)2.64568317
49Gaze-evoked nystagmus (HP:0000640)2.63684006
50Abnormality of the fovea (HP:0000493)2.60798838
51Abnormal number of incisors (HP:0011064)2.60509765
52Abnormality of chromosome stability (HP:0003220)2.59975305
53Hypoplasia of the pons (HP:0012110)2.57159702
54Thrombocytosis (HP:0001894)2.55462142
55Abnormality of DNA repair (HP:0003254)2.55048238
56Patellar aplasia (HP:0006443)2.54698050
57Oral leukoplakia (HP:0002745)2.54200688
58Retinal dysplasia (HP:0007973)2.52123610
5911 pairs of ribs (HP:0000878)2.49687028
60Abnormality of pyrimidine metabolism (HP:0004353)2.49297766
61Pendular nystagmus (HP:0012043)2.48029694
62Bilateral microphthalmos (HP:0007633)2.45315621
63Fair hair (HP:0002286)2.44035272
64Decreased central vision (HP:0007663)2.43851971
65Pachygyria (HP:0001302)2.42248478
66Absent speech (HP:0001344)2.42069438
67Aplasia/Hypoplasia of the patella (HP:0006498)2.39335684
68Deviation of the thumb (HP:0009603)2.38441716
69Proximal placement of thumb (HP:0009623)2.37854803
70Meckel diverticulum (HP:0002245)2.37343962
71Renal cortical cysts (HP:0000803)2.36976073
72Missing ribs (HP:0000921)2.36842171
73Increased corneal curvature (HP:0100692)2.34433713
74Keratoconus (HP:0000563)2.34433713
75Abnormality of the ileum (HP:0001549)2.29669834
76Neoplasm of the oral cavity (HP:0100649)2.27575069
77Macrocytic anemia (HP:0001972)2.26753281
78Medial flaring of the eyebrow (HP:0010747)2.26289706
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.25854224
80Neoplasm of the pancreas (HP:0002894)2.23195117
81Abnormality of the preputium (HP:0100587)2.21283336
82Trismus (HP:0000211)2.18786284
83Agnosia (HP:0010524)2.18070752
84Squamous cell carcinoma (HP:0002860)2.17818069
85Broad-based gait (HP:0002136)2.17792582
86Abnormality of the labia minora (HP:0012880)2.17363745
87Large for gestational age (HP:0001520)2.16982149
88Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14707953
89Short 4th metacarpal (HP:0010044)2.14707953
90Aplasia/Hypoplasia of the macula (HP:0008059)2.14631222
91Supernumerary bones of the axial skeleton (HP:0009144)2.14472830
92Neoplasm of striated muscle (HP:0009728)2.14250860
93Cystic liver disease (HP:0006706)2.13337715
94Increased serum pyruvate (HP:0003542)2.12723547
95Abnormality of glycolysis (HP:0004366)2.12723547
96Supernumerary spleens (HP:0009799)2.11751373
97Aplastic anemia (HP:0001915)2.11637982
98Abolished electroretinogram (ERG) (HP:0000550)2.10717239
99Severe muscular hypotonia (HP:0006829)2.10191543
100Carpal bone hypoplasia (HP:0001498)2.10055618
101Myelodysplasia (HP:0002863)2.09761641
102Abnormality of the renal collecting system (HP:0004742)2.09174187
103Abnormal lung lobation (HP:0002101)2.08851890
104Basal cell carcinoma (HP:0002671)2.08834624
105Generalized hypopigmentation of hair (HP:0011358)2.08479073
106Hypoplastic iliac wings (HP:0002866)2.07680736
107Sclerocornea (HP:0000647)2.07544306
108Progressive cerebellar ataxia (HP:0002073)2.05556559
109Abnormal drinking behavior (HP:0030082)2.05502912
110Polydipsia (HP:0001959)2.05502912
111Male pseudohermaphroditism (HP:0000037)2.04810476
112Congenital hepatic fibrosis (HP:0002612)2.03912967
113Skull defect (HP:0001362)2.03527111
114Absent radius (HP:0003974)2.03397613
115Duplicated collecting system (HP:0000081)2.02620247
116Impulsivity (HP:0100710)2.01356207
117Absent thumb (HP:0009777)2.00823523
118Abnormality of the astrocytes (HP:0100707)2.00417408
119Astrocytoma (HP:0009592)2.00417408
120Increased connective tissue (HP:0009025)1.99532348
121Spastic diplegia (HP:0001264)1.98967296
122Disproportionate short-trunk short stature (HP:0003521)1.98876058
123Abnormality of reticulocytes (HP:0004312)1.98687783
124Rhabdomyolysis (HP:0003201)1.98660049
125Ectopic kidney (HP:0000086)1.98615829
126Bony spicule pigmentary retinopathy (HP:0007737)1.98384358
127Bone marrow hypocellularity (HP:0005528)1.98197324
128Optic nerve hypoplasia (HP:0000609)1.95427718
129Small intestinal stenosis (HP:0012848)1.95269517
130Duodenal stenosis (HP:0100867)1.95269517
131Chorioretinal atrophy (HP:0000533)1.94985217
132Aplasia/Hypoplasia affecting the retina (HP:0008061)1.94845348
133Cellular immunodeficiency (HP:0005374)1.93650581
134Aplasia cutis congenita (HP:0001057)1.93620041
135Hyperglycinuria (HP:0003108)1.93512411
136Conjugated hyperbilirubinemia (HP:0002908)1.92728912
137Biliary tract neoplasm (HP:0100574)1.90724872
138Ketosis (HP:0001946)1.89878385
139Aplasia/Hypoplasia of the uvula (HP:0010293)1.89294787
140Genetic anticipation (HP:0003743)1.88048744
141Unilateral renal agenesis (HP:0000122)1.87603362
142Volvulus (HP:0002580)1.86285606
143Widely spaced teeth (HP:0000687)1.85683551
144IgG deficiency (HP:0004315)1.85478587
145Anencephaly (HP:0002323)1.85443874
1463-Methylglutaconic aciduria (HP:0003535)1.84684871
147Dandy-Walker malformation (HP:0001305)1.84560783
148Absent forearm bone (HP:0003953)1.83969069
149Aplasia involving forearm bones (HP:0009822)1.83969069
150Glioma (HP:0009733)1.82683418
151Rough bone trabeculation (HP:0100670)1.82582684
152Microretrognathia (HP:0000308)1.82375273
153Atresia of the external auditory canal (HP:0000413)1.82061395
154Febrile seizures (HP:0002373)1.81957498
155Drooling (HP:0002307)1.81687351
156Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81069945
157Aplasia/hypoplasia of the humerus (HP:0006507)1.80329441
158Generalized amyotrophy (HP:0003700)1.78283575
159Small hand (HP:0200055)1.77061345
160Premature graying of hair (HP:0002216)1.76626067
161Abnormality of lateral ventricle (HP:0030047)1.76350415
162Short thumb (HP:0009778)1.76349497
163Astigmatism (HP:0000483)1.76341374
164Bulbous nose (HP:0000414)1.76019207
165Tracheoesophageal fistula (HP:0002575)1.75844091
166Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75660136
167Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75660136
168High pitched voice (HP:0001620)1.74957907
169Aplasia/Hypoplasia of the sternum (HP:0006714)1.72025826
170Exercise-induced muscle cramps (HP:0003710)1.71481571
171Sparse lateral eyebrow (HP:0005338)1.71210741
172Abnormality of the 4th metacarpal (HP:0010012)1.71210156
173Aplasia/Hypoplasia of the tibia (HP:0005772)1.71157681
174Short chin (HP:0000331)1.71069997
175Adenoma sebaceum (HP:0009720)1.70306892
176Angiofibromas (HP:0010615)1.70306892
177Clubbing of toes (HP:0100760)1.69875459
178Nephrogenic diabetes insipidus (HP:0009806)1.69839653
179Shawl scrotum (HP:0000049)1.69814722
180Hemivertebrae (HP:0002937)1.69813859
181Decreased circulating renin level (HP:0003351)1.69361380
182Hypobetalipoproteinemia (HP:0003563)1.67391787
183Sloping forehead (HP:0000340)1.67370256
184Polyuria (HP:0000103)1.67241945
185Skin tags (HP:0010609)1.66667354
186Preauricular skin tag (HP:0000384)1.66638301
187Enlarged kidneys (HP:0000105)1.66486973
188Aplasia/Hypoplasia of the tongue (HP:0010295)1.65834807
189Facial diplegia (HP:0001349)1.65593565
190Abnormality of the duodenum (HP:0002246)1.65444435
191Intestinal atresia (HP:0011100)1.65296828
192Ventricular tachycardia (HP:0004756)1.65294131
193Stomach cancer (HP:0012126)1.64358645
194Tachypnea (HP:0002789)1.64046074
195Amaurosis fugax (HP:0100576)1.63971162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.16048474
2PINK14.45126304
3CDK124.44130927
4PASK3.63524413
5WEE13.27104365
6CDC73.21636462
7BUB12.77700032
8NEK22.71803551
9BMPR1B2.68016235
10MAP4K22.49390959
11TLK12.48201752
12PKN22.46790509
13ADRBK22.36101061
14WNK42.16087086
15MARK32.12148425
16MAP3K42.11641327
17CDK72.10083776
18SRPK12.09433765
19TAOK32.07387687
20BCKDK2.04582322
21TTK2.04536362
22WNK32.00950727
23CASK1.99243025
24FLT31.94010819
25TSSK61.91548952
26NEK11.87782489
27TNIK1.82798303
28STK101.80835301
29CDK41.79631217
30TXK1.79439451
31RPS6KB21.77706605
32EPHA21.75101241
33NME21.69333741
34MAP3K101.69006215
35MAPK131.66166198
36PLK11.61463292
37BRD41.60885488
38MAP2K71.58612589
39CAMKK21.56870592
40INSRR1.55057488
41EEF2K1.54998417
42AURKB1.53928743
43ZAK1.49009808
44ATR1.48455065
45NUAK11.48340232
46GRK11.47425733
47MAP2K31.46785632
48TTN1.43944445
49MKNK21.39639864
50MKNK11.38286999
51MAP3K81.37511629
52OBSCN1.32759855
53STK391.32144443
54TGFBR11.28955096
55SIK21.24933678
56STK41.22912170
57PAK41.21763950
58BRSK21.21498362
59TESK21.16818071
60CHEK11.15390404
61EIF2AK11.14385266
62PLK31.14028097
63OXSR11.13153555
64BLK1.12363620
65PIM11.10753285
66CAMK1D1.10191221
67RPS6KA41.10013402
68EPHA41.09692086
69PHKG11.09241408
70PHKG21.09241408
71ACVR1B1.07459871
72VRK11.05888376
73CDK61.03626367
74ALK1.02697498
75AURKA0.95800340
76EIF2AK30.95470552
77NLK0.94908251
78CHEK20.94218053
79ADRBK10.92291654
80IRAK10.90172427
81CSNK1A1L0.89224194
82PLK40.88266326
83PAK30.87587271
84DYRK20.86279340
85CDK20.85619536
86PIK3CA0.85444729
87KDR0.83665817
88TIE10.83037293
89PTK2B0.82608854
90PRKCQ0.81828697
91TEC0.80661276
92GRK60.80338994
93CSNK1G10.79961057
94ATM0.79602386
95TRIB30.79317492
96CAMK1G0.79076487
97MARK10.74384605
98CSNK1G30.74141976
99STK110.74012374
100MTOR0.72604634
101PAK20.69372677
102DYRK30.69292948
103CSNK1G20.69271074
104RIPK40.67926697
105TAOK20.66950200
106CSNK2A20.65804276
107MUSK0.65735867
108CAMK40.65721068
109CDK80.65664488
110MAPKAPK50.64609463
111LRRK20.64127022
112MELK0.61760683
113MAP3K30.61578341
114MAP4K10.59983826
115MAP3K90.59753467
116MAP3K60.57626562
117RPS6KC10.56048439
118RPS6KL10.56048439
119BMPR20.55859742
120STK30.55648182
121CDK10.55288621
122AKT20.55223779
123PRKCG0.54900494
124MAP3K50.53837286
125SCYL20.53765208
126MAP3K70.52986533
127PRKCE0.52931198
128RPS6KA60.51818427
129PRKCI0.51509720
130STK160.51312482
131CSNK2A10.50227315
132PRKAA10.50191721
133CDK90.50119258
134FGFR10.49855315
135RPS6KB10.49763991
136WNK10.49606517
137STK240.49072640
138PDK30.48677297
139PDK40.48677297
140SGK20.47390519
141STK380.46952536
142PAK10.46474863
143PRKAA20.45968565
144ITK0.44935642
145CSNK1E0.44623199
146TRPM70.44491486
147MYLK0.43058053
148EPHA30.42855842
149LATS20.42486698
150PIK3CG0.41269681
151PDGFRA0.41256950
152PRKDC0.40802424
153MAP3K130.39542529
154ICK0.38901714
155RPS6KA50.37618614
156BTK0.35414044
157IKBKB0.35006066
158CSNK1D0.34615086
159PIM20.34361765
160MAPK140.34344650
161PTK60.34176609
162MAP2K60.33637236
163CAMK10.33125647
164SYK0.33094078
165ZAP700.32852350
166MAP3K110.30943090
167PNCK0.30787482
168MAPK110.30253566
169SIK10.29895151
170CSNK1A10.29170751
171STK38L0.29099065
172ABL10.28231955
173PRKCZ0.26498708
174PRKACA0.24247916

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.36197760
2Mismatch repair_Homo sapiens_hsa034303.72407452
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.43129845
4One carbon pool by folate_Homo sapiens_hsa006703.30361671
5Ribosome_Homo sapiens_hsa030103.05364933
6Spliceosome_Homo sapiens_hsa030402.96459460
7Homologous recombination_Homo sapiens_hsa034402.92445900
8Linoleic acid metabolism_Homo sapiens_hsa005912.91212225
9RNA transport_Homo sapiens_hsa030132.87607909
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.76972879
11Base excision repair_Homo sapiens_hsa034102.76691205
12Butanoate metabolism_Homo sapiens_hsa006502.65114800
13Phototransduction_Homo sapiens_hsa047442.61165502
14RNA polymerase_Homo sapiens_hsa030202.43122361
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.34927502
16Non-homologous end-joining_Homo sapiens_hsa034502.30649833
17Nucleotide excision repair_Homo sapiens_hsa034202.29177941
18Cell cycle_Homo sapiens_hsa041102.28711463
19Pyrimidine metabolism_Homo sapiens_hsa002402.25784330
20Caffeine metabolism_Homo sapiens_hsa002322.19584153
21Olfactory transduction_Homo sapiens_hsa047402.11747794
22Nitrogen metabolism_Homo sapiens_hsa009102.05087780
23Primary bile acid biosynthesis_Homo sapiens_hsa001202.03641096
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97090569
25Proteasome_Homo sapiens_hsa030501.90902326
26Fanconi anemia pathway_Homo sapiens_hsa034601.76708460
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.74496606
28mRNA surveillance pathway_Homo sapiens_hsa030151.73636385
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73110223
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70840191
31Selenocompound metabolism_Homo sapiens_hsa004501.68180679
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66476225
33RNA degradation_Homo sapiens_hsa030181.64305767
34ABC transporters_Homo sapiens_hsa020101.59894445
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59112010
36Ether lipid metabolism_Homo sapiens_hsa005651.58015100
37Biosynthesis of amino acids_Homo sapiens_hsa012301.53256496
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49632842
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.46417681
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.44352386
41Retinol metabolism_Homo sapiens_hsa008301.41038386
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39124625
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33338024
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30869027
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.30574961
46p53 signaling pathway_Homo sapiens_hsa041151.28981895
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28561788
48Nicotine addiction_Homo sapiens_hsa050331.25461894
49Systemic lupus erythematosus_Homo sapiens_hsa053221.22726527
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21185814
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.20459758
52Basal transcription factors_Homo sapiens_hsa030221.18740464
53Regulation of autophagy_Homo sapiens_hsa041401.18471896
54Carbon metabolism_Homo sapiens_hsa012001.17763934
55Arachidonic acid metabolism_Homo sapiens_hsa005901.17477247
56beta-Alanine metabolism_Homo sapiens_hsa004101.17155656
57Sulfur relay system_Homo sapiens_hsa041221.15508237
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.14498080
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13966416
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09769259
61Peroxisome_Homo sapiens_hsa041461.05305535
62Dorso-ventral axis formation_Homo sapiens_hsa043201.03261221
63Taste transduction_Homo sapiens_hsa047420.98833928
64Morphine addiction_Homo sapiens_hsa050320.98547642
65Purine metabolism_Homo sapiens_hsa002300.95244777
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93581841
67Epstein-Barr virus infection_Homo sapiens_hsa051690.89829756
68Circadian rhythm_Homo sapiens_hsa047100.88663594
69Vitamin B6 metabolism_Homo sapiens_hsa007500.87184164
70Pentose phosphate pathway_Homo sapiens_hsa000300.86524137
71Herpes simplex infection_Homo sapiens_hsa051680.84765583
72Primary immunodeficiency_Homo sapiens_hsa053400.84538061
73Viral carcinogenesis_Homo sapiens_hsa052030.83293152
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83284560
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83209699
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82503899
77Folate biosynthesis_Homo sapiens_hsa007900.81796676
78Lysine degradation_Homo sapiens_hsa003100.80076137
79Basal cell carcinoma_Homo sapiens_hsa052170.79559728
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79459563
81HTLV-I infection_Homo sapiens_hsa051660.79004056
82Glycerolipid metabolism_Homo sapiens_hsa005610.78173487
83Small cell lung cancer_Homo sapiens_hsa052220.76204829
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75357588
85MicroRNAs in cancer_Homo sapiens_hsa052060.72639829
86Thyroid cancer_Homo sapiens_hsa052160.70271948
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.69829953
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69506421
89Calcium signaling pathway_Homo sapiens_hsa040200.68046696
90Glutathione metabolism_Homo sapiens_hsa004800.67812696
91Fructose and mannose metabolism_Homo sapiens_hsa000510.67201466
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66856545
93Antigen processing and presentation_Homo sapiens_hsa046120.62551190
94Ovarian steroidogenesis_Homo sapiens_hsa049130.61158747
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60624519
96Glutamatergic synapse_Homo sapiens_hsa047240.60435018
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.59893853
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59694825
99Serotonergic synapse_Homo sapiens_hsa047260.56340299
100Fatty acid degradation_Homo sapiens_hsa000710.54212426
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52233543
102Pyruvate metabolism_Homo sapiens_hsa006200.52050730
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51329305
104Legionellosis_Homo sapiens_hsa051340.50464501
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50027698
106Salivary secretion_Homo sapiens_hsa049700.49942300
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49658402
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49019324
109Notch signaling pathway_Homo sapiens_hsa043300.48869030
110Circadian entrainment_Homo sapiens_hsa047130.48290210
111Long-term depression_Homo sapiens_hsa047300.46201817
112Huntingtons disease_Homo sapiens_hsa050160.46000023
113Hippo signaling pathway_Homo sapiens_hsa043900.44952108
114HIF-1 signaling pathway_Homo sapiens_hsa040660.44193341
115Oxytocin signaling pathway_Homo sapiens_hsa049210.43670670
116Viral myocarditis_Homo sapiens_hsa054160.43396703
117Oocyte meiosis_Homo sapiens_hsa041140.41692264
118Galactose metabolism_Homo sapiens_hsa000520.41103707
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40915956
120Sulfur metabolism_Homo sapiens_hsa009200.40681056
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.39954402
122Propanoate metabolism_Homo sapiens_hsa006400.39452229
123Insulin secretion_Homo sapiens_hsa049110.39248302
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37590562
125Arginine biosynthesis_Homo sapiens_hsa002200.37132570
126Arginine and proline metabolism_Homo sapiens_hsa003300.36126335
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.35296251
128Oxidative phosphorylation_Homo sapiens_hsa001900.35281319
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35161258
130Histidine metabolism_Homo sapiens_hsa003400.34616881
131Fat digestion and absorption_Homo sapiens_hsa049750.34505532
132Alcoholism_Homo sapiens_hsa050340.34402418
133Chronic myeloid leukemia_Homo sapiens_hsa052200.34291359
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.33318111
135GABAergic synapse_Homo sapiens_hsa047270.32900360
136Apoptosis_Homo sapiens_hsa042100.32569277
137Bladder cancer_Homo sapiens_hsa052190.32550174
138Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31275206
139TGF-beta signaling pathway_Homo sapiens_hsa043500.31259564
140T cell receptor signaling pathway_Homo sapiens_hsa046600.30928442
141Pathways in cancer_Homo sapiens_hsa052000.30264511
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30152608
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29989063
144Hedgehog signaling pathway_Homo sapiens_hsa043400.29287536
145FoxO signaling pathway_Homo sapiens_hsa040680.29095157
146Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28024018
147N-Glycan biosynthesis_Homo sapiens_hsa005100.28007987
148Metabolic pathways_Homo sapiens_hsa011000.26236430
149Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24074213
150Chemical carcinogenesis_Homo sapiens_hsa052040.21362344
151Adherens junction_Homo sapiens_hsa045200.21195181
152Phenylalanine metabolism_Homo sapiens_hsa003600.21092770
153Proteoglycans in cancer_Homo sapiens_hsa052050.20776460
154Hepatitis B_Homo sapiens_hsa051610.20306290
155Non-small cell lung cancer_Homo sapiens_hsa052230.19793516
156Fatty acid metabolism_Homo sapiens_hsa012120.17746161
157Tryptophan metabolism_Homo sapiens_hsa003800.17628765
158Parkinsons disease_Homo sapiens_hsa050120.16540787
159Intestinal immune network for IgA production_Homo sapiens_hsa046720.16222693
160Insulin resistance_Homo sapiens_hsa049310.15699882
161Tyrosine metabolism_Homo sapiens_hsa003500.15596465

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