

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | presynaptic membrane assembly (GO:0097105) | 4.19867001 |
| 2 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.94232557 |
| 3 | presynaptic membrane organization (GO:0097090) | 3.59386343 |
| 4 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 3.55040490 |
| 5 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 3.55040490 |
| 6 | regulation of translation, ncRNA-mediated (GO:0045974) | 3.55040490 |
| 7 | interkinetic nuclear migration (GO:0022027) | 3.52606363 |
| 8 | neuron cell-cell adhesion (GO:0007158) | 3.51491397 |
| 9 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 3.44943062 |
| 10 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.32880069 |
| 11 | vocalization behavior (GO:0071625) | 3.28891230 |
| 12 | nuclear pore complex assembly (GO:0051292) | 3.25328493 |
| 13 | negative regulation of dendrite development (GO:2000171) | 3.22454924 |
| 14 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.18324180 |
| 15 | protein localization to synapse (GO:0035418) | 3.17902050 |
| 16 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.17854259 |
| 17 | startle response (GO:0001964) | 3.07064613 |
| 18 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.05970960 |
| 19 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.03420631 |
| 20 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 2.98787254 |
| 21 | positive regulation of cardiac muscle cell differentiation (GO:2000727) | 2.97022567 |
| 22 | innervation (GO:0060384) | 2.96892641 |
| 23 | negative regulation of neurotransmitter transport (GO:0051589) | 2.91501305 |
| 24 | glutamate receptor signaling pathway (GO:0007215) | 2.91412118 |
| 25 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 2.91213038 |
| 26 | pre-miRNA processing (GO:0031054) | 2.90392565 |
| 27 | neuron recognition (GO:0008038) | 2.88434321 |
| 28 | nuclear pore organization (GO:0006999) | 2.85699264 |
| 29 | negative regulation of neurotransmitter secretion (GO:0046929) | 2.84548198 |
| 30 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.81791869 |
| 31 | embryonic retina morphogenesis in camera-type eye (GO:0060059) | 2.81679980 |
| 32 | regulation of pigment cell differentiation (GO:0050932) | 2.81095916 |
| 33 | axonal fasciculation (GO:0007413) | 2.79513745 |
| 34 | dendritic spine morphogenesis (GO:0060997) | 2.78814823 |
| 35 | postsynaptic membrane organization (GO:0001941) | 2.78623090 |
| 36 | dendrite morphogenesis (GO:0048813) | 2.78456890 |
| 37 | regulation of glutamate receptor signaling pathway (GO:1900449) | 2.78449495 |
| 38 | paraxial mesoderm development (GO:0048339) | 2.77884252 |
| 39 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.75684801 |
| 40 | mitotic sister chromatid cohesion (GO:0007064) | 2.75207693 |
| 41 | dendrite development (GO:0016358) | 2.74735371 |
| 42 | membrane assembly (GO:0071709) | 2.72451575 |
| 43 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.71606050 |
| 44 | neuron-neuron synaptic transmission (GO:0007270) | 2.71019085 |
| 45 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.70032363 |
| 46 | locomotory exploration behavior (GO:0035641) | 2.68183507 |
| 47 | establishment of nucleus localization (GO:0040023) | 2.67840157 |
| 48 | NLS-bearing protein import into nucleus (GO:0006607) | 2.67792085 |
| 49 | neuronal action potential propagation (GO:0019227) | 2.67326841 |
| 50 | vesicle transport along microtubule (GO:0047496) | 2.66316861 |
| 51 | glutamate secretion (GO:0014047) | 2.65378776 |
| 52 | central nervous system neuron axonogenesis (GO:0021955) | 2.62881729 |
| 53 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 2.61178664 |
| 54 | synaptic transmission, glutamatergic (GO:0035249) | 2.60193817 |
| 55 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.60055996 |
| 56 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 2.59081872 |
| 57 | long-term synaptic potentiation (GO:0060291) | 2.58789659 |
| 58 | regulation of protein polyubiquitination (GO:1902914) | 2.56306669 |
| 59 | regulation of axon extension involved in axon guidance (GO:0048841) | 2.55095227 |
| 60 | establishment of protein localization to Golgi (GO:0072600) | 2.54591291 |
| 61 | regulation of dendritic spine development (GO:0060998) | 2.53351696 |
| 62 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.51239620 |
| 63 | morphogenesis of an epithelial sheet (GO:0002011) | 2.50308199 |
| 64 | lipid translocation (GO:0034204) | 2.49628427 |
| 65 | phospholipid translocation (GO:0045332) | 2.49628427 |
| 66 | regulation of postsynaptic membrane potential (GO:0060078) | 2.49497257 |
| 67 | cerebellar granule cell differentiation (GO:0021707) | 2.47754687 |
| 68 | regulation of axon guidance (GO:1902667) | 2.47377728 |
| 69 | synaptic vesicle maturation (GO:0016188) | 2.45119080 |
| 70 | regulation of hippo signaling (GO:0035330) | 2.45069096 |
| 71 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.44725889 |
| 72 | regulation of neuronal synaptic plasticity (GO:0048168) | 2.44318353 |
| 73 | synaptic vesicle exocytosis (GO:0016079) | 2.44304389 |
| 74 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.43793505 |
| 75 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.40932116 |
| 76 | regulation of synaptic vesicle transport (GO:1902803) | 2.39402427 |
| 77 | mechanosensory behavior (GO:0007638) | 2.38845499 |
| 78 | microtubule anchoring (GO:0034453) | 2.38246113 |
| 79 | embryonic foregut morphogenesis (GO:0048617) | 2.38190954 |
| 80 | regulation of transforming growth factor beta2 production (GO:0032909) | 2.37522848 |
| 81 | organelle transport along microtubule (GO:0072384) | 2.36517572 |
| 82 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.36377675 |
| 83 | histone H3-K4 trimethylation (GO:0080182) | 2.34379020 |
| 84 | artery development (GO:0060840) | 2.33861911 |
| 85 | positive regulation of muscle hypertrophy (GO:0014742) | 2.33149126 |
| 86 | positive regulation of cardiac muscle hypertrophy (GO:0010613) | 2.33149126 |
| 87 | negative regulation of keratinocyte proliferation (GO:0010839) | 2.33094367 |
| 88 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 2.32700034 |
| 89 | synapse assembly (GO:0007416) | 2.32558516 |
| 90 | regulation of synapse assembly (GO:0051963) | 2.31194410 |
| 91 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.30779765 |
| 92 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787) | 2.30600972 |
| 93 | exploration behavior (GO:0035640) | 2.30539998 |
| 94 | nucleus localization (GO:0051647) | 2.30240221 |
| 95 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.29971099 |
| 96 | histone H3-K36 demethylation (GO:0070544) | 2.29527534 |
| 97 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 2.29028399 |
| 98 | atrial cardiac muscle cell action potential (GO:0086014) | 2.28954701 |
| 99 | behavioral defense response (GO:0002209) | 2.28150694 |
| 100 | behavioral fear response (GO:0001662) | 2.28150694 |
| 101 | pericardium development (GO:0060039) | 2.26653838 |
| 102 | regulation of establishment of cell polarity (GO:2000114) | 2.26064798 |
| 103 | genitalia morphogenesis (GO:0035112) | 2.25819388 |
| 104 | synaptic vesicle endocytosis (GO:0048488) | 2.24964904 |
| 105 | myelination in peripheral nervous system (GO:0022011) | 2.24911414 |
| 106 | peripheral nervous system axon ensheathment (GO:0032292) | 2.24911414 |
| 107 | protein targeting to Golgi (GO:0000042) | 2.24866921 |
| 108 | nerve growth factor signaling pathway (GO:0038180) | 2.24599633 |
| 109 | positive regulation of synapse assembly (GO:0051965) | 2.24557323 |
| 110 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 2.24477923 |
| 111 | regulation of Rac protein signal transduction (GO:0035020) | 2.23431906 |
| 112 | cell migration in hindbrain (GO:0021535) | 2.22997982 |
| 113 | apical protein localization (GO:0045176) | 2.22581494 |
| 114 | gastrulation with mouth forming second (GO:0001702) | 2.22130646 |
| 115 | negative regulation of DNA repair (GO:0045738) | 2.21853881 |
| 116 | centrosome localization (GO:0051642) | 2.20256882 |
| 117 | auditory behavior (GO:0031223) | 2.19754705 |
| 118 | transmission of nerve impulse (GO:0019226) | 2.19427765 |
| 119 | dorsal/ventral axis specification (GO:0009950) | 2.19279456 |
| 120 | pore complex assembly (GO:0046931) | 2.19220541 |
| 121 | asymmetric protein localization (GO:0008105) | 2.18601948 |
| 122 | myelin assembly (GO:0032288) | 2.18585444 |
| 123 | ER overload response (GO:0006983) | 2.17768101 |
| 124 | response to histamine (GO:0034776) | 2.17362677 |
| 125 | embryonic camera-type eye morphogenesis (GO:0048596) | 2.17164311 |
| 126 | dendritic spine organization (GO:0097061) | 2.16923814 |
| 127 | proline transport (GO:0015824) | 2.16915693 |
| 128 | inositol phosphate catabolic process (GO:0071545) | 2.16836306 |
| 129 | axon extension (GO:0048675) | 2.16325939 |
| 130 | regulation of synaptic plasticity (GO:0048167) | 2.16107843 |
| 131 | prostate gland growth (GO:0060736) | 2.16004123 |
| 132 | serotonin receptor signaling pathway (GO:0007210) | 2.15907961 |
| 133 | regulation of posttranscriptional gene silencing (GO:0060147) | 2.15855734 |
| 134 | regulation of gene silencing by miRNA (GO:0060964) | 2.15855734 |
| 135 | regulation of gene silencing by RNA (GO:0060966) | 2.15855734 |
| 136 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 2.15616041 |
| 137 | protein localization to microtubule cytoskeleton (GO:0072698) | 2.15076952 |
| 138 | cerebral cortex cell migration (GO:0021795) | 2.14565339 |
| 139 | hippo signaling (GO:0035329) | 2.14179841 |
| 140 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.13867708 |
| 141 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 2.13639511 |
| 142 | retina layer formation (GO:0010842) | 2.13434202 |
| 143 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.12690319 |
| 144 | cerebral cortex development (GO:0021987) | 2.12086476 |
| 145 | regulation of establishment or maintenance of cell polarity (GO:0032878) | 2.11062911 |
| 146 | regulation of cAMP-dependent protein kinase activity (GO:2000479) | 2.11013157 |
| 147 | clathrin coat assembly (GO:0048268) | 2.10332720 |
| 148 | peptidyl-threonine phosphorylation (GO:0018107) | 2.10119638 |
| 149 | negative chemotaxis (GO:0050919) | 2.10103237 |
| 150 | neuronal stem cell maintenance (GO:0097150) | 2.09694221 |
| 151 | chondrocyte development (GO:0002063) | 2.09485230 |
| 152 | axon extension involved in axon guidance (GO:0048846) | 2.08714057 |
| 153 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 2.08714057 |
| 154 | learning (GO:0007612) | 2.08677403 |
| 155 | negative regulation of peptidyl-threonine phosphorylation (GO:0010801) | 2.08604604 |
| 156 | monoubiquitinated protein deubiquitination (GO:0035520) | 2.08567286 |
| 157 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 2.08506638 |
| 158 | cytoplasmic mRNA processing body assembly (GO:0033962) | 2.08431906 |
| 159 | Golgi to endosome transport (GO:0006895) | 2.07795764 |
| 160 | regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095) | 2.06732374 |
| 161 | positive regulation of neurological system process (GO:0031646) | 2.06543568 |
| 162 | SMAD protein complex assembly (GO:0007183) | 2.06334458 |
| 163 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.05065383 |
| 164 | suckling behavior (GO:0001967) | 2.04870588 |
| 165 | appendage development (GO:0048736) | 2.04553504 |
| 166 | limb development (GO:0060173) | 2.04553504 |
| 167 | peptidyl-threonine modification (GO:0018210) | 2.04254534 |
| 168 | dermatan sulfate biosynthetic process (GO:0030208) | 2.04170537 |
| 169 | positive regulation of developmental pigmentation (GO:0048087) | 2.03854255 |
| 170 | inner ear receptor cell development (GO:0060119) | 2.02844388 |
| 171 | import into cell (GO:0098657) | 2.02725617 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.88389776 |
| 2 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.97171427 |
| 3 | * CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.76006060 |
| 4 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.61347948 |
| 5 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.59028518 |
| 6 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.41703481 |
| 7 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.40778960 |
| 8 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.23070513 |
| 9 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.18234601 |
| 10 | * SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 2.16961049 |
| 11 | P300_19829295_ChIP-Seq_ESCs_Human | 2.05566807 |
| 12 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.05286111 |
| 13 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.04281260 |
| 14 | FUS_26573619_Chip-Seq_HEK293_Human | 2.03366968 |
| 15 | SMAD4_21799915_ChIP-Seq_A2780_Human | 2.03140840 |
| 16 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 2.00821249 |
| 17 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.95920695 |
| 18 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.90847369 |
| 19 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.90805215 |
| 20 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.90591128 |
| 21 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.90045858 |
| 22 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.89863348 |
| 23 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.88174104 |
| 24 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.85452560 |
| 25 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.85094205 |
| 26 | TP53_16413492_ChIP-PET_HCT116_Human | 1.82269375 |
| 27 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.82065053 |
| 28 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.80252539 |
| 29 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.78175835 |
| 30 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.73319851 |
| 31 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.71512467 |
| 32 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.69761980 |
| 33 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.67869132 |
| 34 | STAT3_23295773_ChIP-Seq_U87_Human | 1.66687033 |
| 35 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.63920842 |
| 36 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.59745505 |
| 37 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.59745505 |
| 38 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.59560620 |
| 39 | EWS_26573619_Chip-Seq_HEK293_Human | 1.58225673 |
| 40 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.57748559 |
| 41 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.56378870 |
| 42 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.53841202 |
| 43 | * ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.53350129 |
| 44 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.53247731 |
| 45 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.51951731 |
| 46 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.51423713 |
| 47 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.50953975 |
| 48 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.50389415 |
| 49 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.49173681 |
| 50 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.49132071 |
| 51 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.47888863 |
| 52 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.47380986 |
| 53 | AR_25329375_ChIP-Seq_VCAP_Human | 1.45509914 |
| 54 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.44560672 |
| 55 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.43905479 |
| 56 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.41544599 |
| 57 | * AHR_22903824_ChIP-Seq_MCF-7_Human | 1.41241861 |
| 58 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.39264673 |
| 59 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.39228904 |
| 60 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.38236678 |
| 61 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.36616527 |
| 62 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.36334508 |
| 63 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.35798440 |
| 64 | * UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.35446686 |
| 65 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.35304136 |
| 66 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.35102855 |
| 67 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.34623052 |
| 68 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.34470838 |
| 69 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.33165780 |
| 70 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.31952817 |
| 71 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.31805876 |
| 72 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.31697438 |
| 73 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.30877436 |
| 74 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.30877436 |
| 75 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.29602711 |
| 76 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.27334412 |
| 77 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.26993660 |
| 78 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.26871226 |
| 79 | VDR_22108803_ChIP-Seq_LS180_Human | 1.26103725 |
| 80 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.25969560 |
| 81 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.24867936 |
| 82 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.24651759 |
| 83 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.23106313 |
| 84 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.22182233 |
| 85 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.21795658 |
| 86 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.20524582 |
| 87 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.20524582 |
| 88 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.20340958 |
| 89 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.19920718 |
| 90 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.18922809 |
| 91 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.18505956 |
| 92 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.18108378 |
| 93 | * YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.17670264 |
| 94 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.15790401 |
| 95 | CJUN_26792858_Chip-Seq_BT549_Human | 1.15778218 |
| 96 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.15632268 |
| 97 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.14615309 |
| 98 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.14063789 |
| 99 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.14063789 |
| 100 | RXR_22108803_ChIP-Seq_LS180_Human | 1.13930410 |
| 101 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.13739055 |
| 102 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 1.13654159 |
| 103 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.13388269 |
| 104 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 1.13308550 |
| 105 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.13259717 |
| 106 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.12262185 |
| 107 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.12179511 |
| 108 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.11758808 |
| 109 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.11529652 |
| 110 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.10061609 |
| 111 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.09518124 |
| 112 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.08976492 |
| 113 | JUN_21703547_ChIP-Seq_K562_Human | 1.08792166 |
| 114 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.08636866 |
| 115 | * AR_19668381_ChIP-Seq_PC3_Human | 1.07929075 |
| 116 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.06829811 |
| 117 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.06598498 |
| 118 | KDM2B_26808549_Chip-Seq_REH_Human | 1.06080326 |
| 119 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.05771642 |
| 120 | * CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.04148323 |
| 121 | * FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 1.02054554 |
| 122 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.01987845 |
| 123 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.01923446 |
| 124 | * FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.01498146 |
| 125 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.01412144 |
| 126 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.01251409 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 3.65014738 |
| 2 | MP0003880_abnormal_central_pattern | 3.53326679 |
| 3 | MP0004270_analgesia | 3.28013677 |
| 4 | MP0008057_abnormal_DNA_replication | 3.25724054 |
| 5 | MP0002009_preneoplasia | 2.89187344 |
| 6 | MP0003787_abnormal_imprinting | 2.79206717 |
| 7 | MP0000569_abnormal_digit_pigmentation | 2.70068115 |
| 8 | MP0003635_abnormal_synaptic_transmissio | 2.55014785 |
| 9 | MP0005171_absent_coat_pigmentation | 2.54281321 |
| 10 | MP0000778_abnormal_nervous_system | 2.32015685 |
| 11 | MP0002063_abnormal_learning/memory/cond | 2.25782646 |
| 12 | MP0001188_hyperpigmentation | 2.23899815 |
| 13 | MP0009745_abnormal_behavioral_response | 2.22617446 |
| 14 | MP0009046_muscle_twitch | 2.20109502 |
| 15 | MP0010352_gastrointestinal_tract_polyps | 2.19843954 |
| 16 | MP0009780_abnormal_chondrocyte_physiolo | 2.12173833 |
| 17 | MP0005187_abnormal_penis_morphology | 2.10311490 |
| 18 | MP0002734_abnormal_mechanical_nocicepti | 2.06117926 |
| 19 | MP0001486_abnormal_startle_reflex | 1.99942971 |
| 20 | MP0002572_abnormal_emotion/affect_behav | 1.92519769 |
| 21 | MP0001968_abnormal_touch/_nociception | 1.91991885 |
| 22 | MP0002064_seizures | 1.84679738 |
| 23 | MP0000383_abnormal_hair_follicle | 1.72162057 |
| 24 | MP0002272_abnormal_nervous_system | 1.71979029 |
| 25 | MP0002735_abnormal_chemical_nociception | 1.71578112 |
| 26 | MP0005367_renal/urinary_system_phenotyp | 1.61538556 |
| 27 | MP0000516_abnormal_urinary_system | 1.61538556 |
| 28 | MP0001299_abnormal_eye_distance/ | 1.58428676 |
| 29 | MP0004084_abnormal_cardiac_muscle | 1.57739364 |
| 30 | MP0005646_abnormal_pituitary_gland | 1.52904161 |
| 31 | MP0001177_atelectasis | 1.51232348 |
| 32 | MP0003121_genomic_imprinting | 1.50940128 |
| 33 | MP0000428_abnormal_craniofacial_morphol | 1.50475037 |
| 34 | MP0002067_abnormal_sensory_capabilities | 1.49926662 |
| 35 | MP0002184_abnormal_innervation | 1.47387467 |
| 36 | MP0002736_abnormal_nociception_after | 1.46290198 |
| 37 | MP0005174_abnormal_tail_pigmentation | 1.45631069 |
| 38 | MP0005409_darkened_coat_color | 1.41339733 |
| 39 | MP0004924_abnormal_behavior | 1.40325798 |
| 40 | MP0005386_behavior/neurological_phenoty | 1.40325798 |
| 41 | MP0001984_abnormal_olfaction | 1.37523144 |
| 42 | MP0000537_abnormal_urethra_morphology | 1.36806290 |
| 43 | MP0005423_abnormal_somatic_nervous | 1.36630764 |
| 44 | MP0003950_abnormal_plasma_membrane | 1.31926734 |
| 45 | MP0003890_abnormal_embryonic-extraembry | 1.27699949 |
| 46 | MP0000372_irregular_coat_pigmentation | 1.26548738 |
| 47 | MP0000015_abnormal_ear_pigmentation | 1.24732528 |
| 48 | MP0003941_abnormal_skin_development | 1.24701358 |
| 49 | MP0005623_abnormal_meninges_morphology | 1.23135129 |
| 50 | MP0004885_abnormal_endolymph | 1.21350476 |
| 51 | MP0010368_abnormal_lymphatic_system | 1.20338246 |
| 52 | MP0003122_maternal_imprinting | 1.19290373 |
| 53 | MP0002557_abnormal_social/conspecific_i | 1.15957902 |
| 54 | MP0003091_abnormal_cell_migration | 1.14660791 |
| 55 | MP0003705_abnormal_hypodermis_morpholog | 1.13729031 |
| 56 | MP0006276_abnormal_autonomic_nervous | 1.13061652 |
| 57 | MP0002882_abnormal_neuron_morphology | 1.12701688 |
| 58 | MP0004811_abnormal_neuron_physiology | 1.11746591 |
| 59 | MP0001440_abnormal_grooming_behavior | 1.10180416 |
| 60 | MP0000432_abnormal_head_morphology | 1.08947364 |
| 61 | MP0010234_abnormal_vibrissa_follicle | 1.08450040 |
| 62 | MP0004742_abnormal_vestibular_system | 1.07919119 |
| 63 | MP0008877_abnormal_DNA_methylation | 1.07017196 |
| 64 | MP0004130_abnormal_muscle_cell | 1.05890574 |
| 65 | MP0000955_abnormal_spinal_cord | 1.05885384 |
| 66 | MP0003385_abnormal_body_wall | 1.05550335 |
| 67 | MP0003937_abnormal_limbs/digits/tail_de | 1.04483626 |
| 68 | MP0004484_altered_response_of | 1.04388487 |
| 69 | MP0003632_abnormal_nervous_system | 1.04122132 |
| 70 | MP0001501_abnormal_sleep_pattern | 1.04082460 |
| 71 | MP0004272_abnormal_basement_membrane | 1.03359669 |
| 72 | MP0008569_lethality_at_weaning | 1.01929617 |
| 73 | MP0002084_abnormal_developmental_patter | 1.01168196 |
| 74 | MP0003755_abnormal_palate_morphology | 1.01082215 |
| 75 | MP0001970_abnormal_pain_threshold | 0.98967550 |
| 76 | MP0005076_abnormal_cell_differentiation | 0.97382783 |
| 77 | MP0002152_abnormal_brain_morphology | 0.96887713 |
| 78 | MP0002697_abnormal_eye_size | 0.96066035 |
| 79 | MP0002733_abnormal_thermal_nociception | 0.93992383 |
| 80 | MP0009250_abnormal_appendicular_skeleto | 0.93672762 |
| 81 | MP0000427_abnormal_hair_cycle | 0.93422230 |
| 82 | MP0009697_abnormal_copulation | 0.93016498 |
| 83 | MP0001286_abnormal_eye_development | 0.92575717 |
| 84 | MP0010678_abnormal_skin_adnexa | 0.92497965 |
| 85 | MP0005551_abnormal_eye_electrophysiolog | 0.91435108 |
| 86 | MP0003045_fibrosis | 0.90417359 |
| 87 | MP0002081_perinatal_lethality | 0.90008401 |
| 88 | MP0002168_other_aberrant_phenotype | 0.89784689 |
| 89 | MP0003631_nervous_system_phenotype | 0.89322722 |
| 90 | MP0009703_decreased_birth_body | 0.89058759 |
| 91 | MP0003942_abnormal_urinary_system | 0.88946717 |
| 92 | MP0001293_anophthalmia | 0.88858137 |
| 93 | MP0000920_abnormal_myelination | 0.88810168 |
| 94 | MP0001879_abnormal_lymphatic_vessel | 0.88626048 |
| 95 | MP0002877_abnormal_melanocyte_morpholog | 0.88472373 |
| 96 | MP0004036_abnormal_muscle_relaxation | 0.87551851 |
| 97 | MP0004134_abnormal_chest_morphology | 0.87284311 |
| 98 | MP0005248_abnormal_Harderian_gland | 0.86148095 |
| 99 | MP0005645_abnormal_hypothalamus_physiol | 0.86098429 |
| 100 | MP0004858_abnormal_nervous_system | 0.85858511 |
| 101 | MP0000579_abnormal_nail_morphology | 0.85131147 |
| 102 | MP0001963_abnormal_hearing_physiology | 0.84006481 |
| 103 | MP0004197_abnormal_fetal_growth/weight/ | 0.83817519 |
| 104 | MP0003634_abnormal_glial_cell | 0.83732763 |
| 105 | MP0002066_abnormal_motor_capabilities/c | 0.83611932 |
| 106 | MP0004145_abnormal_muscle_electrophysio | 0.83415607 |
| 107 | MP0002837_dystrophic_cardiac_calcinosis | 0.83304641 |
| 108 | MP0002092_abnormal_eye_morphology | 0.83093366 |
| 109 | MP0004215_abnormal_myocardial_fiber | 0.81536272 |
| 110 | MP0002925_abnormal_cardiovascular_devel | 0.81019602 |
| 111 | MP0004085_abnormal_heartbeat | 0.80981007 |
| 112 | MP0003861_abnormal_nervous_system | 0.80247799 |
| 113 | MP0005275_abnormal_skin_tensile | 0.80073758 |
| 114 | MP0004233_abnormal_muscle_weight | 0.79959139 |
| 115 | MP0003123_paternal_imprinting | 0.79539156 |
| 116 | MP0002133_abnormal_respiratory_system | 0.79379864 |
| 117 | MP0005388_respiratory_system_phenotype | 0.79379864 |
| 118 | MP0003935_abnormal_craniofacial_develop | 0.79241679 |
| 119 | MP0000631_abnormal_neuroendocrine_gland | 0.78554207 |
| 120 | MP0003633_abnormal_nervous_system | 0.77872128 |
| 121 | MP0000462_abnormal_digestive_system | 0.77855265 |
| 122 | MP0002177_abnormal_outer_ear | 0.77844679 |
| 123 | MP0003136_yellow_coat_color | 0.77519042 |
| 124 | MP0002108_abnormal_muscle_morphology | 0.76807052 |
| 125 | MP0002751_abnormal_autonomic_nervous | 0.76454342 |
| 126 | MP0003315_abnormal_perineum_morphology | 0.76390220 |
| 127 | MP0008438_abnormal_cutaneous_collagen | 0.76009440 |
| 128 | MP0003119_abnormal_digestive_system | 0.75599250 |
| 129 | MP0000534_abnormal_ureter_morphology | 0.75447551 |
| 130 | MP0002088_abnormal_embryonic_growth/wei | 0.75229124 |
| 131 | MP0001485_abnormal_pinna_reflex | 0.74797841 |
| 132 | MP0001915_intracranial_hemorrhage | 0.74690307 |
| 133 | MP0000647_abnormal_sebaceous_gland | 0.74175849 |
| 134 | MP0003984_embryonic_growth_retardation | 0.73841061 |
| 135 | MP0003690_abnormal_glial_cell | 0.72357003 |
| 136 | MP0001502_abnormal_circadian_rhythm | 0.71559272 |
| 137 | MP0002233_abnormal_nose_morphology | 0.71007358 |
| 138 | MP0002752_abnormal_somatic_nervous | 0.70382376 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 4.28475482 |
| 2 | Hyperventilation (HP:0002883) | 3.42430954 |
| 3 | Papillary thyroid carcinoma (HP:0002895) | 3.36176149 |
| 4 | Febrile seizures (HP:0002373) | 3.34062127 |
| 5 | Atonic seizures (HP:0010819) | 3.23346942 |
| 6 | Drooling (HP:0002307) | 3.19760732 |
| 7 | Excessive salivation (HP:0003781) | 3.19760732 |
| 8 | Epileptic encephalopathy (HP:0200134) | 3.11500671 |
| 9 | Aqueductal stenosis (HP:0002410) | 3.05981252 |
| 10 | Progressive cerebellar ataxia (HP:0002073) | 2.93504800 |
| 11 | Broad-based gait (HP:0002136) | 2.89368195 |
| 12 | Abnormality of the nasal septum (HP:0000419) | 2.85660867 |
| 13 | Termporal pattern (HP:0011008) | 2.84069485 |
| 14 | Insidious onset (HP:0003587) | 2.84069485 |
| 15 | Focal seizures (HP:0007359) | 2.75839493 |
| 16 | Abnormal hair whorl (HP:0010721) | 2.74758702 |
| 17 | Widely spaced teeth (HP:0000687) | 2.63837206 |
| 18 | Thyroid carcinoma (HP:0002890) | 2.62895362 |
| 19 | Action tremor (HP:0002345) | 2.62336598 |
| 20 | Gaze-evoked nystagmus (HP:0000640) | 2.52887728 |
| 21 | Protruding tongue (HP:0010808) | 2.48342975 |
| 22 | Absent speech (HP:0001344) | 2.48002894 |
| 23 | Blue irides (HP:0000635) | 2.43465044 |
| 24 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.42047204 |
| 25 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.42047204 |
| 26 | Abnormality of incisor morphology (HP:0011063) | 2.36674767 |
| 27 | Fair hair (HP:0002286) | 2.36504831 |
| 28 | Vertebral arch anomaly (HP:0008438) | 2.35641900 |
| 29 | Genetic anticipation (HP:0003743) | 2.35044984 |
| 30 | Absent eyebrow (HP:0002223) | 2.31350737 |
| 31 | Abnormality of the corticospinal tract (HP:0002492) | 2.29265477 |
| 32 | Asymmetry of the thorax (HP:0001555) | 2.29223760 |
| 33 | Neoplasm of the adrenal cortex (HP:0100641) | 2.27480909 |
| 34 | Generalized hypopigmentation of hair (HP:0011358) | 2.23969734 |
| 35 | Abnormality of the ischium (HP:0003174) | 2.22616240 |
| 36 | Abnormality of salivation (HP:0100755) | 2.20427190 |
| 37 | Macroorchidism (HP:0000053) | 2.18011665 |
| 38 | Exotropia (HP:0000577) | 2.17594392 |
| 39 | Midline defect of the nose (HP:0004122) | 2.15092639 |
| 40 | Truncal obesity (HP:0001956) | 2.13434546 |
| 41 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.11527007 |
| 42 | Heterotopia (HP:0002282) | 2.07777783 |
| 43 | Absence seizures (HP:0002121) | 2.04997338 |
| 44 | Overgrowth (HP:0001548) | 1.99740915 |
| 45 | Inappropriate behavior (HP:0000719) | 1.97868161 |
| 46 | Absent frontal sinuses (HP:0002688) | 1.95605665 |
| 47 | Large earlobe (HP:0009748) | 1.94222752 |
| 48 | Cubitus valgus (HP:0002967) | 1.94107988 |
| 49 | Truncal ataxia (HP:0002078) | 1.93831561 |
| 50 | Myokymia (HP:0002411) | 1.93387385 |
| 51 | Scanning speech (HP:0002168) | 1.90637906 |
| 52 | Fetal akinesia sequence (HP:0001989) | 1.88779963 |
| 53 | Astrocytoma (HP:0009592) | 1.88566523 |
| 54 | Abnormality of the astrocytes (HP:0100707) | 1.88566523 |
| 55 | Pulmonic stenosis (HP:0001642) | 1.88126929 |
| 56 | Abnormality of the labia minora (HP:0012880) | 1.85889286 |
| 57 | Prostate neoplasm (HP:0100787) | 1.85368381 |
| 58 | Lower limb amyotrophy (HP:0007210) | 1.84424229 |
| 59 | Cupped ear (HP:0000378) | 1.83537217 |
| 60 | High anterior hairline (HP:0009890) | 1.82953786 |
| 61 | Oligodactyly (hands) (HP:0001180) | 1.82041337 |
| 62 | Arterial tortuosity (HP:0005116) | 1.81685328 |
| 63 | Acute myeloid leukemia (HP:0004808) | 1.81391192 |
| 64 | Dysmetric saccades (HP:0000641) | 1.80164503 |
| 65 | Glioma (HP:0009733) | 1.80067609 |
| 66 | Volvulus (HP:0002580) | 1.78199883 |
| 67 | Ulnar claw (HP:0001178) | 1.76070047 |
| 68 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.75570158 |
| 69 | Megalencephaly (HP:0001355) | 1.74321346 |
| 70 | Pheochromocytoma (HP:0002666) | 1.73970421 |
| 71 | Dialeptic seizures (HP:0011146) | 1.73779773 |
| 72 | Hypoplastic labia majora (HP:0000059) | 1.73475003 |
| 73 | Aplasia/Hypoplasia of the frontal sinuses (HP:0009119) | 1.72234031 |
| 74 | Thickened helices (HP:0000391) | 1.70189200 |
| 75 | Preaxial foot polydactyly (HP:0001841) | 1.69952472 |
| 76 | Renal hypoplasia (HP:0000089) | 1.69741066 |
| 77 | Cutaneous syndactyly (HP:0012725) | 1.69461045 |
| 78 | Syringomyelia (HP:0003396) | 1.69399012 |
| 79 | Spinal cord lesions (HP:0100561) | 1.69399012 |
| 80 | Neonatal hypoglycemia (HP:0001998) | 1.68832407 |
| 81 | Neoplasm of the oral cavity (HP:0100649) | 1.68730030 |
| 82 | Cystic hygroma (HP:0000476) | 1.68639560 |
| 83 | Abnormal pancreas size (HP:0012094) | 1.68554595 |
| 84 | Amblyopia (HP:0000646) | 1.67584871 |
| 85 | Gastroesophageal reflux (HP:0002020) | 1.67476345 |
| 86 | Narrow palate (HP:0000189) | 1.66392012 |
| 87 | Sensory axonal neuropathy (HP:0003390) | 1.65654370 |
| 88 | Submucous cleft hard palate (HP:0000176) | 1.65052315 |
| 89 | Subacute progressive viral hepatitis (HP:0006572) | 1.65013809 |
| 90 | Aortic aneurysm (HP:0004942) | 1.65006203 |
| 91 | Vascular tortuosity (HP:0004948) | 1.64870765 |
| 92 | Hamartoma (HP:0010566) | 1.64304009 |
| 93 | Deeply set eye (HP:0000490) | 1.64248486 |
| 94 | Transitional cell carcinoma of the bladder (HP:0006740) | 1.64136955 |
| 95 | Cutaneous finger syndactyly (HP:0010554) | 1.63390809 |
| 96 | Hepatoblastoma (HP:0002884) | 1.63038331 |
| 97 | Generalized tonic-clonic seizures (HP:0002069) | 1.62766972 |
| 98 | Short chin (HP:0000331) | 1.62473360 |
| 99 | Difficulty running (HP:0009046) | 1.61594201 |
| 100 | Hypothermia (HP:0002045) | 1.61536295 |
| 101 | Hypoplastic ischia (HP:0003175) | 1.60926522 |
| 102 | Relative macrocephaly (HP:0004482) | 1.60435602 |
| 103 | Lower limb muscle weakness (HP:0007340) | 1.59765622 |
| 104 | Obsessive-compulsive behavior (HP:0000722) | 1.59637640 |
| 105 | Abnormality of the labia majora (HP:0012881) | 1.58680747 |
| 106 | Capillary hemangiomas (HP:0005306) | 1.58234414 |
| 107 | Sandal gap (HP:0001852) | 1.57830021 |
| 108 | Vitreoretinal degeneration (HP:0000655) | 1.57134582 |
| 109 | Stomach cancer (HP:0012126) | 1.56964120 |
| 110 | Genital tract atresia (HP:0001827) | 1.56868189 |
| 111 | Limited hip movement (HP:0008800) | 1.56453535 |
| 112 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.55027194 |
| 113 | Germ cell neoplasia (HP:0100728) | 1.53941956 |
| 114 | Bladder carcinoma (HP:0002862) | 1.53929291 |
| 115 | Bladder neoplasm (HP:0009725) | 1.53929291 |
| 116 | Tapered finger (HP:0001182) | 1.53874252 |
| 117 | Short tibia (HP:0005736) | 1.53873949 |
| 118 | Long eyelashes (HP:0000527) | 1.52691401 |
| 119 | Abnormality of the epiphyses of the hand (HP:0005924) | 1.52306081 |
| 120 | Increased number of teeth (HP:0011069) | 1.51660696 |
| 121 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.51442553 |
| 122 | Short 4th metacarpal (HP:0010044) | 1.51442553 |
| 123 | Urinary urgency (HP:0000012) | 1.50966414 |
| 124 | Aplasia involving bones of the extremities (HP:0009825) | 1.50748623 |
| 125 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.50748623 |
| 126 | Aplasia of the phalanges of the hand (HP:0009802) | 1.50748623 |
| 127 | Dysmetria (HP:0001310) | 1.50643183 |
| 128 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.49375400 |
| 129 | Tracheomalacia (HP:0002779) | 1.48790871 |
| 130 | Wide intermamillary distance (HP:0006610) | 1.48706995 |
| 131 | Omphalocele (HP:0001539) | 1.48113040 |
| 132 | Chin dimple (HP:0010751) | 1.48057777 |
| 133 | Thick eyebrow (HP:0000574) | 1.47921232 |
| 134 | Abnormality of the frontal sinuses (HP:0002687) | 1.47668796 |
| 135 | Abnormality of the 4th metacarpal (HP:0010012) | 1.47593237 |
| 136 | Cortical dysplasia (HP:0002539) | 1.46968999 |
| 137 | Heterochromia iridis (HP:0001100) | 1.46205274 |
| 138 | Bradycardia (HP:0001662) | 1.45961645 |
| 139 | Abnormality of the epiphyses of the phalanges of the hand (HP:0005920) | 1.45785229 |
| 140 | Hypoplasia of the maxilla (HP:0000327) | 1.44749635 |
| 141 | Abnormality of chromosome segregation (HP:0002916) | 1.44496716 |
| 142 | Steppage gait (HP:0003376) | 1.44385926 |
| 143 | Dysdiadochokinesis (HP:0002075) | 1.44358433 |
| 144 | Vaginal atresia (HP:0000148) | 1.43854337 |
| 145 | Deep philtrum (HP:0002002) | 1.43724767 |
| 146 | Curly hair (HP:0002212) | 1.43712806 |
| 147 | Decreased number of peripheral myelinated nerve fibers (HP:0003380) | 1.43710525 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CASK | 4.13573569 |
| 2 | FRK | 3.02739497 |
| 3 | NTRK3 | 2.53601643 |
| 4 | EPHA4 | 2.51826921 |
| 5 | SGK2 | 2.38514500 |
| 6 | PLK2 | 2.34963972 |
| 7 | MAP3K4 | 2.26820027 |
| 8 | AKT3 | 2.11792659 |
| 9 | FGFR2 | 1.94777626 |
| 10 | MARK1 | 1.85659806 |
| 11 | LATS1 | 1.85047676 |
| 12 | MAP2K7 | 1.83432103 |
| 13 | SGK494 | 1.79422770 |
| 14 | SGK223 | 1.79422770 |
| 15 | SGK3 | 1.78815002 |
| 16 | BCR | 1.72673996 |
| 17 | BRD4 | 1.69184322 |
| 18 | ZAK | 1.67091028 |
| 19 | PINK1 | 1.65598981 |
| 20 | PDGFRA | 1.64908011 |
| 21 | MAPK13 | 1.63519457 |
| 22 | PRPF4B | 1.53405209 |
| 23 | BMPR2 | 1.47814493 |
| 24 | MAP3K10 | 1.44444317 |
| 25 | NUAK1 | 1.44264925 |
| 26 | ACVR1B | 1.42297984 |
| 27 | ERBB3 | 1.37257248 |
| 28 | NEK6 | 1.34206982 |
| 29 | PIK3CA | 1.33915097 |
| 30 | CAMK1G | 1.26813709 |
| 31 | NLK | 1.25836153 |
| 32 | CAMK1D | 1.24514325 |
| 33 | KSR1 | 1.20989775 |
| 34 | RIPK4 | 1.18128987 |
| 35 | MINK1 | 1.17414706 |
| 36 | PLK3 | 1.06249012 |
| 37 | SGK1 | 1.05798673 |
| 38 | ERBB4 | 1.03033315 |
| 39 | PRKCE | 1.03033292 |
| 40 | STK38L | 1.01852099 |
| 41 | MKNK2 | 0.99825287 |
| 42 | DMPK | 0.98266157 |
| 43 | PRKD3 | 0.95131772 |
| 44 | STK24 | 0.93407663 |
| 45 | YES1 | 0.92410279 |
| 46 | OBSCN | 0.91247057 |
| 47 | WNK1 | 0.89709264 |
| 48 | TYRO3 | 0.89047487 |
| 49 | NTRK2 | 0.88126003 |
| 50 | MUSK | 0.88000292 |
| 51 | OXSR1 | 0.87763583 |
| 52 | FER | 0.87727761 |
| 53 | MKNK1 | 0.87392156 |
| 54 | FGFR1 | 0.87391341 |
| 55 | NTRK1 | 0.87137084 |
| 56 | NEK9 | 0.86047245 |
| 57 | STK39 | 0.85024244 |
| 58 | MET | 0.84018844 |
| 59 | MAP3K2 | 0.83470950 |
| 60 | FGFR3 | 0.83052404 |
| 61 | BMPR1B | 0.82411098 |
| 62 | NEK2 | 0.82294731 |
| 63 | CAMK2A | 0.80665583 |
| 64 | MAP3K9 | 0.80512565 |
| 65 | CSNK1A1L | 0.79852566 |
| 66 | PKN1 | 0.79345614 |
| 67 | MAP2K4 | 0.78191373 |
| 68 | PAK3 | 0.77949559 |
| 69 | LATS2 | 0.77816989 |
| 70 | RET | 0.76289707 |
| 71 | CSNK1G2 | 0.75897580 |
| 72 | PNCK | 0.75670492 |
| 73 | INSRR | 0.75541811 |
| 74 | CAMKK2 | 0.73421921 |
| 75 | CDK5 | 0.73211820 |
| 76 | CDK3 | 0.73144789 |
| 77 | PAK6 | 0.71947509 |
| 78 | CAMK2B | 0.71904753 |
| 79 | EEF2K | 0.70460777 |
| 80 | STK3 | 0.68321217 |
| 81 | MTOR | 0.67890409 |
| 82 | SIK3 | 0.66179934 |
| 83 | MELK | 0.65846496 |
| 84 | DAPK2 | 0.65571137 |
| 85 | TGFBR1 | 0.65275122 |
| 86 | PTK2B | 0.64026515 |
| 87 | TRPM7 | 0.63706031 |
| 88 | PRKCH | 0.62168186 |
| 89 | BRSK2 | 0.58912345 |
| 90 | MAPK10 | 0.58454307 |
| 91 | CSNK1G1 | 0.57852090 |
| 92 | WNK3 | 0.56902758 |
| 93 | PDGFRB | 0.55781636 |
| 94 | PKN2 | 0.55450056 |
| 95 | MAP3K12 | 0.53898841 |
| 96 | ERBB2 | 0.53620287 |
| 97 | GRK7 | 0.53613677 |
| 98 | GRK5 | 0.53528097 |
| 99 | TNIK | 0.52492928 |
| 100 | STK11 | 0.52355252 |
| 101 | MARK3 | 0.52338080 |
| 102 | DYRK1A | 0.50103617 |
| 103 | PRKCG | 0.49781449 |
| 104 | CCNB1 | 0.48287665 |
| 105 | PRKAA2 | 0.48071210 |
| 106 | PRKAA1 | 0.48012317 |
| 107 | RPS6KB1 | 0.47996000 |
| 108 | * ATM | 0.46844126 |
| 109 | TAF1 | 0.46664719 |
| 110 | SCYL2 | 0.46111904 |
| 111 | STK38 | 0.45472553 |
| 112 | MAP3K7 | 0.45153572 |
| 113 | RPS6KA3 | 0.45095054 |
| 114 | CDK12 | 0.44576089 |
| 115 | FGR | 0.44324979 |
| 116 | CDK8 | 0.42862952 |
| 117 | CAMK2D | 0.42857244 |
| 118 | PRKG1 | 0.42751452 |
| 119 | PAK2 | 0.42346531 |
| 120 | EPHA3 | 0.41471625 |
| 121 | CAMK1 | 0.40834481 |
| 122 | WEE1 | 0.40752764 |
| 123 | RPS6KA2 | 0.40153549 |
| 124 | ROCK1 | 0.39468489 |
| 125 | CAMK4 | 0.38336563 |
| 126 | CAMKK1 | 0.37560838 |
| 127 | EGFR | 0.34603711 |
| 128 | RAF1 | 0.34557913 |
| 129 | CSNK1D | 0.34306630 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 2.85569422 |
| 2 | Long-term potentiation_Homo sapiens_hsa04720 | 2.15887574 |
| 3 | Circadian entrainment_Homo sapiens_hsa04713 | 2.05652757 |
| 4 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.02850607 |
| 5 | Olfactory transduction_Homo sapiens_hsa04740 | 1.93436169 |
| 6 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.92412436 |
| 7 | Morphine addiction_Homo sapiens_hsa05032 | 1.87493266 |
| 8 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.82219477 |
| 9 | GABAergic synapse_Homo sapiens_hsa04727 | 1.79302959 |
| 10 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.65890144 |
| 11 | Renin secretion_Homo sapiens_hsa04924 | 1.65424946 |
| 12 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.60403510 |
| 13 | Long-term depression_Homo sapiens_hsa04730 | 1.59409268 |
| 14 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.56183530 |
| 15 | Axon guidance_Homo sapiens_hsa04360 | 1.52289238 |
| 16 | Phototransduction_Homo sapiens_hsa04744 | 1.52004040 |
| 17 | Salivary secretion_Homo sapiens_hsa04970 | 1.48837567 |
| 18 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.47719414 |
| 19 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.38704231 |
| 20 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.34954796 |
| 21 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.34360810 |
| 22 | Taste transduction_Homo sapiens_hsa04742 | 1.33177571 |
| 23 | Glioma_Homo sapiens_hsa05214 | 1.31370369 |
| 24 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.28726484 |
| 25 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.28139039 |
| 26 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.24944953 |
| 27 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.23951146 |
| 28 | Insulin secretion_Homo sapiens_hsa04911 | 1.23402516 |
| 29 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.21139490 |
| 30 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.20931289 |
| 31 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.20597254 |
| 32 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.19971303 |
| 33 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.19473514 |
| 34 | Melanogenesis_Homo sapiens_hsa04916 | 1.16086934 |
| 35 | Cocaine addiction_Homo sapiens_hsa05030 | 1.15712501 |
| 36 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.14137900 |
| 37 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.13780643 |
| 38 | Lysine degradation_Homo sapiens_hsa00310 | 1.12609406 |
| 39 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.10347470 |
| 40 | Gap junction_Homo sapiens_hsa04540 | 1.09402677 |
| 41 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.07769494 |
| 42 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.04195317 |
| 43 | Endometrial cancer_Homo sapiens_hsa05213 | 1.03369309 |
| 44 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.03144389 |
| 45 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.02855640 |
| 46 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.02372940 |
| 47 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.02038798 |
| 48 | Melanoma_Homo sapiens_hsa05218 | 1.00324438 |
| 49 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.00253135 |
| 50 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.98611394 |
| 51 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.98542003 |
| 52 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.96070957 |
| 53 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.95698197 |
| 54 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.95349153 |
| 55 | Prostate cancer_Homo sapiens_hsa05215 | 0.94818259 |
| 56 | Adherens junction_Homo sapiens_hsa04520 | 0.94422348 |
| 57 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.93506129 |
| 58 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.92910715 |
| 59 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.91076012 |
| 60 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.91042535 |
| 61 | * MAPK signaling pathway_Homo sapiens_hsa04010 | 0.89926130 |
| 62 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.89284143 |
| 63 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.87742731 |
| 64 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.87669352 |
| 65 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.85538319 |
| 66 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.85093951 |
| 67 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.83865046 |
| 68 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.83032674 |
| 69 | Focal adhesion_Homo sapiens_hsa04510 | 0.82258494 |
| 70 | Thyroid cancer_Homo sapiens_hsa05216 | 0.82216961 |
| 71 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.80030436 |
| 72 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.77645963 |
| 73 | Colorectal cancer_Homo sapiens_hsa05210 | 0.77272363 |
| 74 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.76861446 |
| 75 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.76844567 |
| 76 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.76834503 |
| 77 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.76642150 |
| 78 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.76439847 |
| 79 | Tight junction_Homo sapiens_hsa04530 | 0.74330227 |
| 80 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.71294259 |
| 81 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.71044005 |
| 82 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.71019967 |
| 83 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.69857555 |
| 84 | Alcoholism_Homo sapiens_hsa05034 | 0.69706531 |
| 85 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.68319749 |
| 86 | Circadian rhythm_Homo sapiens_hsa04710 | 0.68000360 |
| 87 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.67304553 |
| 88 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.67194039 |
| 89 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.67089533 |
| 90 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.66402185 |
| 91 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.66246479 |
| 92 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.65406984 |
| 93 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.65303962 |
| 94 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.63980554 |
| 95 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.62679974 |
| 96 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.61991071 |
| 97 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.61743740 |
| 98 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.59638048 |
| 99 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.59469067 |
| 100 | Amoebiasis_Homo sapiens_hsa05146 | 0.58434135 |
| 101 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.57871648 |
| 102 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.54222821 |
| 103 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.54113558 |
| 104 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.53650210 |
| 105 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.53593941 |
| 106 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.52838294 |
| 107 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.52350955 |
| 108 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.52038983 |
| 109 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.51750480 |
| 110 | Pathways in cancer_Homo sapiens_hsa05200 | 0.50987880 |
| 111 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.49281271 |
| 112 | Platelet activation_Homo sapiens_hsa04611 | 0.48244073 |

