TAOK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of autophagic vacuole assembly (GO:2000785)4.59498461
2cellular response to exogenous dsRNA (GO:0071360)4.57334798
3negative regulation of macroautophagy (GO:0016242)4.45658815
4positive regulation of gamma-delta T cell activation (GO:0046645)4.34090150
5neutrophil activation involved in immune response (GO:0002283)4.32558913
6antigen processing and presentation of endogenous antigen (GO:0019883)4.27661616
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.21157945
8regulation of B cell receptor signaling pathway (GO:0050855)4.14205979
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.14070367
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.14070367
11cytidine deamination (GO:0009972)4.11719185
12cytidine metabolic process (GO:0046087)4.11719185
13cytidine catabolic process (GO:0006216)4.11719185
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.96062740
15positive regulation by organism of defense response of other organism involved in symbiotic interact3.96062740
16modulation by symbiont of host immune response (GO:0052553)3.96062740
17positive regulation by symbiont of host defense response (GO:0052509)3.96062740
18modulation by symbiont of host defense response (GO:0052031)3.96062740
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.96062740
20regulation of vacuole organization (GO:0044088)3.82418479
21immunoglobulin mediated immune response (GO:0016064)3.74075014
22regulation of interferon-beta biosynthetic process (GO:0045357)3.73793734
23microglial cell activation (GO:0001774)3.69586745
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.64037192
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56970406
26negative regulation of cell killing (GO:0031342)3.56970406
27respiratory burst (GO:0045730)3.52530903
28B cell receptor signaling pathway (GO:0050853)3.50866395
29positive regulation of granulocyte differentiation (GO:0030854)3.50371574
30positive regulation of B cell differentiation (GO:0045579)3.49733785
31mast cell activation (GO:0045576)3.43011324
32response to peptidoglycan (GO:0032494)3.38267961
33neutrophil activation (GO:0042119)3.36262092
34macrophage activation involved in immune response (GO:0002281)3.31688954
35negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.30917072
36response to type I interferon (GO:0034340)3.28858063
37myeloid cell activation involved in immune response (GO:0002275)3.26440402
38type I interferon signaling pathway (GO:0060337)3.24616234
39cellular response to type I interferon (GO:0071357)3.24616234
40T cell migration (GO:0072678)3.24332680
41granulocyte activation (GO:0036230)3.20655599
42negative regulation of T cell mediated immunity (GO:0002710)3.19880561
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.17772716
44positive thymic T cell selection (GO:0045059)3.16109906
45regulation of B cell differentiation (GO:0045577)3.14022070
46interferon-gamma-mediated signaling pathway (GO:0060333)3.12048523
47Arp2/3 complex-mediated actin nucleation (GO:0034314)3.07433190
48cellular extravasation (GO:0045123)3.06280278
49positive regulation of antigen processing and presentation (GO:0002579)3.06178063
50myeloid dendritic cell activation (GO:0001773)3.03284563
51megakaryocyte development (GO:0035855)2.99672345
52positive regulation of interferon-alpha production (GO:0032727)2.95847285
53regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.91890540
54negative regulation of erythrocyte differentiation (GO:0045647)2.91753808
55negative regulation of interleukin-12 production (GO:0032695)2.91741220
56defense response to protozoan (GO:0042832)2.91672987
57mature B cell differentiation (GO:0002335)2.89356236
58regulation of female receptivity (GO:0045924)2.89240535
59pyrimidine ribonucleoside catabolic process (GO:0046133)2.88336990
60activated T cell proliferation (GO:0050798)2.86036267
61regulation of hypersensitivity (GO:0002883)2.85675950
62antigen processing and presentation via MHC class Ib (GO:0002475)2.85374739
63regulation of vitamin metabolic process (GO:0030656)2.85174764
64positive regulation of mast cell activation (GO:0033005)2.84230055
65positive T cell selection (GO:0043368)2.84224407
66regulation of interferon-alpha production (GO:0032647)2.83553939
67regulation of mast cell degranulation (GO:0043304)2.83529726
68negative thymic T cell selection (GO:0045060)2.82629185
69regulation of mast cell activation (GO:0033003)2.81379679
70response to host immune response (GO:0052572)2.80814164
71response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.80814164
72negative T cell selection (GO:0043383)2.80418386
73thrombin receptor signaling pathway (GO:0070493)2.80227832
74mature B cell differentiation involved in immune response (GO:0002313)2.80041974
75positive regulation of interleukin-1 beta secretion (GO:0050718)2.79861406
76cellular response to interferon-beta (GO:0035458)2.79716161
77mucosal-associated lymphoid tissue development (GO:0048537)2.78601719
78Peyers patch development (GO:0048541)2.78601719
79regulation of alpha-beta T cell proliferation (GO:0046640)2.77695497
80myeloid dendritic cell differentiation (GO:0043011)2.77101555
81positive regulation of alpha-beta T cell proliferation (GO:0046641)2.75878610
82tolerance induction (GO:0002507)2.75405207
83definitive hemopoiesis (GO:0060216)2.75180410
84actin nucleation (GO:0045010)2.74846411
85regulation of germinal center formation (GO:0002634)2.74283474
86negative regulation of lymphocyte mediated immunity (GO:0002707)2.74018687
87regulation of gamma-delta T cell activation (GO:0046643)2.73527699
88leukocyte mediated cytotoxicity (GO:0001909)2.73337046
89production of molecular mediator involved in inflammatory response (GO:0002532)2.72545359
90regulation of gamma-delta T cell differentiation (GO:0045586)2.71727869
91natural killer cell mediated immunity (GO:0002228)2.71247188
92natural killer cell mediated cytotoxicity (GO:0042267)2.71247188
93response to protozoan (GO:0001562)2.70755910
94positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.70660647
95regulation of interleukin-12 biosynthetic process (GO:0045075)2.70040965
96macrophage activation (GO:0042116)2.69799994
97purinergic nucleotide receptor signaling pathway (GO:0035590)2.69796017
98germinal center formation (GO:0002467)2.68998716
99interferon-gamma production (GO:0032609)2.68943130
100regulation of antigen processing and presentation (GO:0002577)2.68505293
101leukocyte aggregation (GO:0070486)2.68433494
102leukocyte degranulation (GO:0043299)2.67226411
103aggressive behavior (GO:0002118)2.66957435
104antigen receptor-mediated signaling pathway (GO:0050851)2.66868807
105lipopolysaccharide-mediated signaling pathway (GO:0031663)2.66271002
106positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.65389428
107negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.64590022
108neutrophil mediated immunity (GO:0002446)2.64406181
109mast cell degranulation (GO:0043303)2.64237895
110mast cell activation involved in immune response (GO:0002279)2.64237895
111myeloid leukocyte activation (GO:0002274)2.63866572
112positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.63682891
113negative regulation of phagocytosis (GO:0050765)2.62000534
114positive regulation of interleukin-1 secretion (GO:0050716)2.61197460
115positive regulation of mast cell degranulation (GO:0043306)2.60869213
116positive regulation of mast cell activation involved in immune response (GO:0033008)2.60869213
117positive regulation of B cell activation (GO:0050871)2.60071728
118regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.59904534
119regulation of T cell receptor signaling pathway (GO:0050856)2.59580521
120regulation of granulocyte differentiation (GO:0030852)2.58846552
121B cell mediated immunity (GO:0019724)2.58808228
122detection of other organism (GO:0098543)2.58292268
123sulfate transmembrane transport (GO:1902358)2.58123771
124regulation of interleukin-1 beta secretion (GO:0050706)2.58044296
125NAD biosynthetic process (GO:0009435)2.57580085
126NIK/NF-kappaB signaling (GO:0038061)2.57093698
127regulation of mast cell activation involved in immune response (GO:0033006)2.56687764
128B cell homeostasis (GO:0001782)2.56018648
129response to muramyl dipeptide (GO:0032495)2.54418433
130response to fungus (GO:0009620)2.54051862
131regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.53363017
132autophagic vacuole fusion (GO:0000046)2.53059540
133positive regulation of humoral immune response (GO:0002922)2.52989645
134regulation of myeloid leukocyte mediated immunity (GO:0002886)2.52299049
135positive regulation of T cell differentiation in thymus (GO:0033089)2.52124853
136positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.52104259
137positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.51120600
138response to interleukin-15 (GO:0070672)2.50650192
139sleep (GO:0030431)2.49644951
140regulation of T-helper 1 cell differentiation (GO:0045625)2.49446399
141regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.49440515
142negative regulation of leukocyte mediated immunity (GO:0002704)2.48924529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.91292186
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.27734445
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.72939467
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.90091503
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.72457166
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.72001438
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.68503203
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.67198067
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.59860932
10SCL_19346495_ChIP-Seq_HPC-7_Human3.50864442
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.50858996
12EZH2_22144423_ChIP-Seq_EOC_Human3.49308088
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.94886969
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.75361301
15GATA1_22025678_ChIP-Seq_K562_Human2.68425748
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.66265429
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.54227290
18* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.47993643
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.47282556
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.37276594
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.25722380
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15444529
23SPI1_23547873_ChIP-Seq_NB4_Human2.13566431
24RUNX_20019798_ChIP-Seq_JUKART_Human2.09539042
25VDR_24763502_ChIP-Seq_THP-1_Human2.09537990
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.08176621
27VDR_21846776_ChIP-Seq_THP-1_Human2.06282999
28* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.94770771
29MYB_26560356_Chip-Seq_TH2_Human1.94109305
30* GATA1_19941827_ChIP-Seq_MEL_Mouse1.93943398
31IGF1R_20145208_ChIP-Seq_DFB_Human1.93315657
32* RUNX1_22412390_ChIP-Seq_EML_Mouse1.92748784
33MAF_26560356_Chip-Seq_TH1_Human1.91102542
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90867793
35* SPI1_23127762_ChIP-Seq_K562_Human1.90272934
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89618362
37* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86531626
38* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.84338496
39MYB_26560356_Chip-Seq_TH1_Human1.80054129
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.76443990
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68698751
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67188294
43* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66313690
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65558020
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62668077
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.59633222
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59044391
48* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.57444404
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57343822
50* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.52540616
51GBX2_23144817_ChIP-Seq_PC3_Human1.52159547
52PU_27001747_Chip-Seq_BMDM_Mouse1.51398891
53UTX_26944678_Chip-Seq_JUKART_Human1.50912075
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.49742338
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49546032
56ZNF274_21170338_ChIP-Seq_K562_Hela1.47710200
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45576769
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.45091874
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44939811
60* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41454474
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40252997
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39335697
63GATA3_27048872_Chip-Seq_THYMUS_Human1.38096046
64VDR_24787735_ChIP-Seq_THP-1_Human1.37596318
65* TCF7_22412390_ChIP-Seq_EML_Mouse1.30681724
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29932107
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29777840
68RXR_22158963_ChIP-Seq_LIVER_Mouse1.27178910
69* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25433842
70GATA1_19941826_ChIP-Seq_K562_Human1.25275011
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24290853
72PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23217212
73MYC_22102868_ChIP-Seq_BL_Human1.21807019
74VDR_22108803_ChIP-Seq_LS180_Human1.19230260
75* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17561324
76SMRT_27268052_Chip-Seq_Bcells_Human1.16384568
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14162755
78GATA3_26560356_Chip-Seq_TH2_Human1.13672855
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.13644054
80* GATA2_19941826_ChIP-Seq_K562_Human1.12801566
81MAF_26560356_Chip-Seq_TH2_Human1.12325514
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11446809
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11084949
84CBP_20019798_ChIP-Seq_JUKART_Human1.10919263
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10919263
86SMAD_19615063_ChIP-ChIP_OVARY_Human1.09389337
87* GATA2_21666600_ChIP-Seq_HMVEC_Human1.07872718
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07768046
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07067526
90IRF1_19129219_ChIP-ChIP_H3396_Human1.06097759
91ER_23166858_ChIP-Seq_MCF-7_Human1.05976698
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03477133
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03444324
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01420331
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00756407
96LXR_22158963_ChIP-Seq_LIVER_Mouse0.99613756
97CIITA_25753668_ChIP-Seq_RAJI_Human0.98916089
98TP53_22573176_ChIP-Seq_HFKS_Human0.97946740
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97725335
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96030255
101* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93627792
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93470250
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93003747
104CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92272296
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91463436
106EGR1_19032775_ChIP-ChIP_M12_Human0.91309429
107CDX2_20551321_ChIP-Seq_CACO-2_Human0.88285023
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87997273
109FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87412891
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87102479
111* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86726459
112FLI1_21867929_ChIP-Seq_TH2_Mouse0.86209184
113FLI1_27457419_Chip-Seq_LIVER_Mouse0.85569902
114NOTCH1_21737748_ChIP-Seq_TLL_Human0.84465093
115* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.84251215
116ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83680055
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81137696
118GATA3_26560356_Chip-Seq_TH1_Human0.80571810
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79808603
120ETV2_25802403_ChIP-Seq_MESCs_Mouse0.79771792
121ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79518604
122STAT1_20625510_ChIP-Seq_HELA_Human0.79002614
123KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78888371
124VDR_23849224_ChIP-Seq_CD4+_Human0.78146194
125TAF15_26573619_Chip-Seq_HEK293_Human0.78126643
126PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77985060
127ETS1_22383799_ChIP-Seq_G1ME_Mouse0.77536792
128* TCF4_23295773_ChIP-Seq_U87_Human0.77457917
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.76043680
130GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75174853
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71859949
132HOXB4_20404135_ChIP-ChIP_EML_Mouse0.71179412
133NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.70177591
134CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69438021
135* KDM2B_26808549_Chip-Seq_DND41_Human0.68617890
136SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.68373902
137TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.66591300
138RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.65069197
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64907562

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.50622467
2MP0005387_immune_system_phenotype3.08865843
3MP0001790_abnormal_immune_system3.08865843
4MP0003436_decreased_susceptibility_to2.96363977
5MP0003303_peritoneal_inflammation2.92004696
6MP0005671_abnormal_response_to2.91267384
7MP0002148_abnormal_hypersensitivity_rea2.71874868
8MP0001800_abnormal_humoral_immune2.69915252
9MP0005058_abnormal_lysosome_morphology2.69558578
10MP0005000_abnormal_immune_tolerance2.69536450
11MP0000685_abnormal_immune_system2.69384159
12MP0009785_altered_susceptibility_to2.65984123
13MP0005025_abnormal_response_to2.64668365
14MP0002419_abnormal_innate_immunity2.64484955
15MP0002452_abnormal_antigen_presenting2.50880573
16MP0003724_increased_susceptibility_to2.43973667
17MP0002723_abnormal_immune_serum2.41134043
18MP0005464_abnormal_platelet_physiology2.40510367
19MP0001819_abnormal_immune_cell2.27861719
20MP0002420_abnormal_adaptive_immunity2.27279327
21MP0002138_abnormal_hepatobiliary_system2.17425322
22MP0006082_CNS_inflammation2.12804099
23MP0009278_abnormal_bone_marrow2.04283528
24MP0003172_abnormal_lysosome_physiology1.99592990
25MP0005174_abnormal_tail_pigmentation1.96895374
26MP0005310_abnormal_salivary_gland1.95291525
27MP0003787_abnormal_imprinting1.93499243
28MP0002398_abnormal_bone_marrow1.88995227
29MP0003806_abnormal_nucleotide_metabolis1.87852838
30MP0000716_abnormal_immune_system1.81637214
31MP0004510_myositis1.80191910
32MP0002396_abnormal_hematopoietic_system1.75874925
33MP0003183_abnormal_peptide_metabolism1.75757267
34MP0002405_respiratory_system_inflammati1.75416522
35MP0010155_abnormal_intestine_physiology1.74605703
36MP0003763_abnormal_thymus_physiology1.74282803
37MP0003656_abnormal_erythrocyte_physiolo1.71936754
38MP0000569_abnormal_digit_pigmentation1.71304121
39MP0001845_abnormal_inflammatory_respons1.70381669
40MP0004947_skin_inflammation1.69020419
41MP0003866_abnormal_defecation1.61420651
42MP0003300_gastrointestinal_ulcer1.59782337
43MP0000689_abnormal_spleen_morphology1.57350234
44MP0005646_abnormal_pituitary_gland1.55589373
45MP0002166_altered_tumor_susceptibility1.53412321
46MP0008469_abnormal_protein_level1.52270891
47MP0000465_gastrointestinal_hemorrhage1.50993695
48MP0002429_abnormal_blood_cell1.48430143
49MP0002722_abnormal_immune_system1.46711756
50MP0001853_heart_inflammation1.44361007
51MP0008995_early_reproductive_senescence1.44107706
52MP0001873_stomach_inflammation1.43641470
53MP0009764_decreased_sensitivity_to1.39289849
54MP0005360_urolithiasis1.36721745
55MP0003283_abnormal_digestive_organ1.36503495
56MP0002139_abnormal_hepatobiliary_system1.36107871
57MP0010234_abnormal_vibrissa_follicle1.35856143
58MP0001533_abnormal_skeleton_physiology1.35304934
59MP0008877_abnormal_DNA_methylation1.34678571
60MP0009333_abnormal_splenocyte_physiolog1.34348702
61MP0005365_abnormal_bile_salt1.32935225
62MP0001545_abnormal_hematopoietic_system1.31419869
63MP0005397_hematopoietic_system_phenotyp1.31419869
64MP0001666_abnormal_nutrient_absorption1.23919303
65MP0005085_abnormal_gallbladder_physiolo1.23901851
66MP0009840_abnormal_foam_cell1.16178361
67MP0002006_tumorigenesis1.14374146
68MP0003252_abnormal_bile_duct1.13346773
69MP0005645_abnormal_hypothalamus_physiol1.12608765
70MP0000604_amyloidosis1.12450892
71MP0003191_abnormal_cellular_cholesterol1.12151254
72MP0000015_abnormal_ear_pigmentation1.11924257
73MP0003011_delayed_dark_adaptation1.09256940
74MP0004142_abnormal_muscle_tone1.08428499
75MP0001986_abnormal_taste_sensitivity1.06298376
76MP0008875_abnormal_xenobiotic_pharmacok1.05892774
77MP0001663_abnormal_digestive_system1.04762113
78MP0004782_abnormal_surfactant_physiolog1.01083896
79MP0000490_abnormal_crypts_of0.99079635
80MP0003075_altered_response_to0.97559612
81MP0002095_abnormal_skin_pigmentation0.97032146
82MP0005451_abnormal_body_composition0.96769747
83MP0003045_fibrosis0.94534413
84MP0002132_abnormal_respiratory_system0.93931443
85MP0000858_altered_metastatic_potential0.93225832
86MP0005083_abnormal_biliary_tract0.92929189
87MP0000703_abnormal_thymus_morphology0.92252298
88MP0008872_abnormal_physiological_respon0.90951564
89MP0001905_abnormal_dopamine_level0.88032357
90MP0003828_pulmonary_edema0.87754215
91MP0000372_irregular_coat_pigmentation0.87355964
92MP0005075_abnormal_melanosome_morpholog0.86952522
93MP0010329_abnormal_lipoprotein_level0.86366727
94MP0001501_abnormal_sleep_pattern0.85569494
95MP0004147_increased_porphyrin_level0.83793418
96MP0002998_abnormal_bone_remodeling0.83676794
97MP0004883_abnormal_blood_vessel0.83637852
98MP0004808_abnormal_hematopoietic_stem0.83520390
99MP0004019_abnormal_vitamin_homeostasis0.83434316
100MP0009763_increased_sensitivity_to0.82798621
101MP0000343_altered_response_to0.82248801
102MP0005166_decreased_susceptibility_to0.79874741
103MP0004484_altered_response_of0.79714871
104MP0005381_digestive/alimentary_phenotyp0.79466744
105MP0000609_abnormal_liver_physiology0.78968978
106MP0002277_abnormal_respiratory_mucosa0.76543759
107MP0004885_abnormal_endolymph0.76113528
108MP0001851_eye_inflammation0.75902955
109MP0005535_abnormal_body_temperature0.73995608
110MP0008874_decreased_physiological_sensi0.73345380
111MP0004381_abnormal_hair_follicle0.73078269
112MP0001968_abnormal_touch/_nociception0.72956999
113MP0002933_joint_inflammation0.72646606
114MP0005379_endocrine/exocrine_gland_phen0.72335123
115MP0005584_abnormal_enzyme/coenzyme_acti0.72176751
116MP0002928_abnormal_bile_duct0.70149956
117MP0008004_abnormal_stomach_pH0.70114734
118MP0002733_abnormal_thermal_nociception0.69786207
119MP0009745_abnormal_behavioral_response0.68436674
120MP0006276_abnormal_autonomic_nervous0.67901391
121MP0003448_altered_tumor_morphology0.67830790
122MP0005084_abnormal_gallbladder_morpholo0.66867052
123MP0004043_abnormal_pH_regulation0.65412693
124MP0005636_abnormal_mineral_homeostasis0.63569982
125MP0003566_abnormal_cell_adhesion0.63329946
126MP0004742_abnormal_vestibular_system0.63042758
127MP0003718_maternal_effect0.62057452
128MP0005551_abnormal_eye_electrophysiolog0.60516085
129MP0002693_abnormal_pancreas_physiology0.60339502
130MP0009643_abnormal_urine_homeostasis0.59072941
131MP0009765_abnormal_xenobiotic_induced0.58833823

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.09498830
2Recurrent bacterial skin infections (HP:0005406)4.76590894
3Eczematoid dermatitis (HP:0000976)4.37641059
4Posterior subcapsular cataract (HP:0007787)4.36738817
5Recurrent gram-negative bacterial infections (HP:0005420)3.95130561
6Petechiae (HP:0000967)3.89946456
7Recurrent fungal infections (HP:0002841)3.88363500
8Recurrent viral infections (HP:0004429)3.86464338
9Recurrent skin infections (HP:0001581)3.60495768
10Vacuolated lymphocytes (HP:0001922)3.57169820
11Abnormality of B cell number (HP:0010975)3.44821284
12Recurrent cutaneous fungal infections (HP:0011370)3.43003812
13Chronic mucocutaneous candidiasis (HP:0002728)3.43003812
14Abnormality of macrophages (HP:0004311)3.35214269
15Elevated erythrocyte sedimentation rate (HP:0003565)3.32989527
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.29313684
17Panhypogammaglobulinemia (HP:0003139)3.18524745
18Meningitis (HP:0001287)3.18267823
19Autoimmune hemolytic anemia (HP:0001890)3.14417795
20Chronic otitis media (HP:0000389)3.13361154
21Agammaglobulinemia (HP:0004432)3.12118728
22Gingival bleeding (HP:0000225)3.10332316
23Chronic obstructive pulmonary disease (HP:0006510)3.09559524
24Obstructive lung disease (HP:0006536)3.09559524
25Mediastinal lymphadenopathy (HP:0100721)3.06016330
26Myositis (HP:0100614)3.04290358
27Gingivitis (HP:0000230)2.98159361
28Stomach cancer (HP:0012126)2.97864206
29Increased neuronal autofluorescent lipopigment (HP:0002074)2.96354432
30Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.94412892
31Prolonged bleeding time (HP:0003010)2.93747126
32Increased cerebral lipofuscin (HP:0011813)2.87353218
33Epistaxis (HP:0000421)2.82871930
34Pustule (HP:0200039)2.81453107
35Vasculitis (HP:0002633)2.80567950
36Dysostosis multiplex (HP:0000943)2.78967513
37Autoimmune thrombocytopenia (HP:0001973)2.75928088
38Acute lymphatic leukemia (HP:0006721)2.73005019
39Periodontitis (HP:0000704)2.67583645
40Cellulitis (HP:0100658)2.66544921
41Flat capital femoral epiphysis (HP:0003370)2.64609576
42Stomatitis (HP:0010280)2.59444946
43IgM deficiency (HP:0002850)2.59405373
44B lymphocytopenia (HP:0010976)2.59182250
45Aplastic anemia (HP:0001915)2.57950262
46Interstitial pulmonary disease (HP:0006530)2.57319862
47Increased IgE level (HP:0003212)2.56997527
48Inflammation of the large intestine (HP:0002037)2.56900175
49Joint hemorrhage (HP:0005261)2.56504196
50Abnormality of T cell physiology (HP:0011840)2.52898589
51Renal cortical cysts (HP:0000803)2.52236426
52Colitis (HP:0002583)2.51384601
53Abnormality of the heme biosynthetic pathway (HP:0010472)2.50622158
54Abnormality of eosinophils (HP:0001879)2.48749776
55Optic neuritis (HP:0100653)2.47747574
56Retrobulbar optic neuritis (HP:0100654)2.47747574
57Flat acetabular roof (HP:0003180)2.43678222
58Gastrointestinal infarctions (HP:0005244)2.40613554
59Gastrointestinal inflammation (HP:0004386)2.37634473
60Orchitis (HP:0100796)2.37167057
61Chest pain (HP:0100749)2.34017526
62Abnormality of T cells (HP:0002843)2.31120560
63Pulmonary infiltrates (HP:0002113)2.30916961
64Abnormality of the prostate (HP:0008775)2.30408813
65Encephalitis (HP:0002383)2.30329843
66Abnormality of the thoracic spine (HP:0100711)2.28823575
67Congenital stationary night blindness (HP:0007642)2.28779203
68Leukocytosis (HP:0001974)2.27657559
69Menorrhagia (HP:0000132)2.27576782
70Systemic lupus erythematosus (HP:0002725)2.26470985
71Urticaria (HP:0001025)2.25016703
72Exertional dyspnea (HP:0002875)2.24965660
73Abnormal platelet function (HP:0011869)2.21571347
74Impaired platelet aggregation (HP:0003540)2.21571347
75Spontaneous hematomas (HP:0007420)2.20955379
76Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.20707383
77Abnormal platelet volume (HP:0011876)2.20025536
78Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18313413
79Abnormality of polysaccharide metabolism (HP:0011012)2.18313413
80Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18313413
81Joint swelling (HP:0001386)2.18291984
82Purpura (HP:0000979)2.16960257
83Thoracic kyphosis (HP:0002942)2.16711330
84Subcapsular cataract (HP:0000523)2.16186648
85Chronic diarrhea (HP:0002028)2.15530834
86Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14705592
87Recurrent bronchitis (HP:0002837)2.14374033
88Large earlobe (HP:0009748)2.13138610
89Keratoconjunctivitis sicca (HP:0001097)2.12265683
90Severe combined immunodeficiency (HP:0004430)2.11696881
91Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11623424
92Granulocytopenia (HP:0001913)2.10630011
93Vertigo (HP:0002321)2.10102601
94Myocardial infarction (HP:0001658)2.09313420
95Eosinophilia (HP:0001880)2.08776132
96Increased IgM level (HP:0003496)2.07784106
97Recurrent sinusitis (HP:0011108)2.07024005
98Urinary glycosaminoglycan excretion (HP:0003541)2.06444673
99Mucopolysacchariduria (HP:0008155)2.06444673
100Thrombocytosis (HP:0001894)2.05514216
101Abnormality of T cell number (HP:0011839)2.05081136
102Hip dysplasia (HP:0001385)2.04907104
103Flattened epiphyses (HP:0003071)2.04805516
104Abnormality of DNA repair (HP:0003254)2.04386098
105T lymphocytopenia (HP:0005403)2.04204827
106Osteomyelitis (HP:0002754)2.03330565
107Arterial thrombosis (HP:0004420)2.03254145
108Keratoconjunctivitis (HP:0001096)2.02985748
109Abnormality of lateral ventricle (HP:0030047)2.02229991
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01327285
111Thyroiditis (HP:0100646)2.00607965
112Poikilocytosis (HP:0004447)1.99986780
113Cheilitis (HP:0100825)1.99337270
114Hypergammaglobulinemia (HP:0010702)1.99312340
115Progressive visual loss (HP:0000529)1.98876033
116Abnormality of glycolipid metabolism (HP:0010969)1.97786182
117Abnormality of liposaccharide metabolism (HP:0010968)1.97786182
118Abnormality of glycosphingolipid metabolism (HP:0004343)1.97786182
119Recurrent pneumonia (HP:0006532)1.96998368
120Hemoptysis (HP:0002105)1.96143157
121Combined immunodeficiency (HP:0005387)1.95597726
122Prolonged partial thromboplastin time (HP:0003645)1.94606935
123Thyroid-stimulating hormone excess (HP:0002925)1.94590612
124Decreased central vision (HP:0007663)1.92530542
125Amaurosis fugax (HP:0100576)1.88908260
126IgG deficiency (HP:0004315)1.88288503
127Pulmonary embolism (HP:0002204)1.87957118
128Abnormality of the renal cortex (HP:0011035)1.84412682
129Hemiplegia (HP:0002301)1.83961074
130Neutropenia (HP:0001875)1.83072135
131Skin rash (HP:0000988)1.82315851
132Abnormal rod and cone electroretinograms (HP:0008323)1.81354624
1333-Methylglutaconic aciduria (HP:0003535)1.80911289
134Abnormality of iron homeostasis (HP:0011031)1.80586052
135Sepsis (HP:0100806)1.78904963
136Neurodegeneration (HP:0002180)1.77292832
137Alveolar cell carcinoma (HP:0006519)1.76708489
138Chronic sinusitis (HP:0011109)1.75967006
139Hypochromic anemia (HP:0001931)1.75463573
140Abnormality of the renal collecting system (HP:0004742)1.75280852

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.98436716
2MAP3K143.56969220
3BLK3.34149412
4RIPK43.18304631
5IRAK42.93845655
6KIT2.84545770
7* TAOK32.82054233
8MAP3K132.81525288
9TXK2.80202298
10TYK22.65927020
11TBK12.12292597
12JAK32.03606826
13IKBKE2.01558530
14BTK2.00115428
15GRK61.96038820
16SYK1.95001921
17FES1.94643982
18BCKDK1.91416694
19TEC1.86540995
20EPHB21.84839245
21IRAK31.84668060
22PIM21.79903590
23ZAP701.79135483
24JAK11.70496577
25MAPK131.67781850
26ITK1.59939872
27CSF1R1.55060839
28MAP3K121.53660197
29IKBKB1.52491721
30MAP2K31.47282713
31FRK1.38921602
32LCK1.32440161
33LYN1.30235694
34CSK1.29492576
35CLK11.28967444
36SIK21.28856589
37ERN11.12548246
38MAP3K111.09743742
39HCK1.09365662
40JAK21.07212059
41DAPK21.06402814
42PINK11.05107358
43STK101.05081075
44EPHB11.03082139
45FGFR41.02414606
46GRK11.02125014
47PRKCQ1.00944533
48CHUK0.98563116
49MATK0.95457319
50TESK20.91656139
51MAP4K20.89653604
52PBK0.87526676
53PIM10.87411285
54RIPK10.87222899
55MARK30.83147727
56HIPK20.80742851
57FLT30.78929011
58BMPR20.76687270
59TAOK10.72849130
60INSRR0.72141543
61MAPK110.69542778
62CAMK1G0.68835326
63MAPK120.67503444
64MAP2K40.67079774
65NEK90.66826740
66MAP3K50.64547126
67TNK20.61977660
68MAP3K40.59714674
69BMPR1B0.59686816
70MAP3K60.58141560
71PIK3CG0.57533115
72MAP3K90.54751384
73PTK2B0.54595383
74MAP3K10.53970464
75RPS6KA50.53351236
76FGR0.52413068
77PRKD20.52350383
78GRK50.51720151
79NTRK20.51152740
80CDK190.50414164
81GRK70.50311930
82CAMKK20.49309138
83ABL10.47771751
84TNIK0.47667499
85SGK20.47648555
86NME20.47633454
87PRPF4B0.47533047
88PKN10.46232268
89MAP2K70.45886339
90STK40.45649102
91TGFBR20.45316807
92PDK10.45265376
93MAP2K60.44815756
94MAPK40.44746708
95ABL20.43410565
96PIK3CA0.42962602
97NUAK10.42357947
98EGFR0.41248308
99MAPK70.41102496
100PRKCD0.39966866
101RAF10.39563501
102MAP2K20.39384251
103MOS0.39090449
104PRKG20.38795603
105ADRBK10.38218325
106SGK10.37596964
107IGF1R0.37520617
108IRAK10.37178116
109YES10.37101362
110FYN0.37041671
111TRPM70.36266932
112FGFR30.34873354
113MAPK150.33963852
114DAPK10.33324792
115PRKAA20.33204297
116ADRBK20.33054538
117CDK30.33047423
118RPS6KA60.32080360
119PTK60.31837740
120ARAF0.31100407
121EPHA30.30924395
122NTRK30.29111366
123MARK20.28889752
124OXSR10.28879328
125PDPK10.27112215
126NLK0.26746474
127NEK60.25708202
128MAPK30.25440226
129PRKD10.25345316
130SRC0.25246871
131MAPKAPK20.24996549
132CDK60.24627760
133DYRK1A0.24542779
134SGK30.23998167
135PRKCA0.22656973
136ILK0.22384239
137PRKG10.22333763
138CCNB10.22224416
139TLK10.22065597

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.88566975
2Leishmaniasis_Homo sapiens_hsa051402.84489225
3Staphylococcus aureus infection_Homo sapiens_hsa051502.64502299
4B cell receptor signaling pathway_Homo sapiens_hsa046622.48067110
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.39915525
6Osteoclast differentiation_Homo sapiens_hsa043802.36678403
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.35658527
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.27176006
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.12489262
10Measles_Homo sapiens_hsa051622.07249144
11Other glycan degradation_Homo sapiens_hsa005111.97558396
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89270995
13Pertussis_Homo sapiens_hsa051331.85946346
14Hematopoietic cell lineage_Homo sapiens_hsa046401.81713873
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.77584002
16T cell receptor signaling pathway_Homo sapiens_hsa046601.72966139
17Tuberculosis_Homo sapiens_hsa051521.71913073
18Phototransduction_Homo sapiens_hsa047441.69261071
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66570253
20Allograft rejection_Homo sapiens_hsa053301.64843160
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63969099
22Lysosome_Homo sapiens_hsa041421.63077990
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59652085
24Chemokine signaling pathway_Homo sapiens_hsa040621.58720475
25Caffeine metabolism_Homo sapiens_hsa002321.56522046
26Antigen processing and presentation_Homo sapiens_hsa046121.54630046
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52953382
28TNF signaling pathway_Homo sapiens_hsa046681.46573993
29Influenza A_Homo sapiens_hsa051641.43161057
30Graft-versus-host disease_Homo sapiens_hsa053321.42203413
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38630494
32Malaria_Homo sapiens_hsa051441.36830174
33Toxoplasmosis_Homo sapiens_hsa051451.36144659
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35955601
35Acute myeloid leukemia_Homo sapiens_hsa052211.35281441
36Asthma_Homo sapiens_hsa053101.33398482
37Apoptosis_Homo sapiens_hsa042101.32065550
38ABC transporters_Homo sapiens_hsa020101.30472463
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.27455818
40Complement and coagulation cascades_Homo sapiens_hsa046101.19747540
41Chronic myeloid leukemia_Homo sapiens_hsa052201.19535444
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18586058
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.16794652
44Herpes simplex infection_Homo sapiens_hsa051681.16429663
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13513945
46Hepatitis B_Homo sapiens_hsa051611.12332865
47Hepatitis C_Homo sapiens_hsa051601.09895013
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.06540562
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05907190
50Legionellosis_Homo sapiens_hsa051341.03901125
51Salmonella infection_Homo sapiens_hsa051321.01258933
52Phagosome_Homo sapiens_hsa041451.00865743
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00019623
54Platelet activation_Homo sapiens_hsa046110.99046989
55Shigellosis_Homo sapiens_hsa051310.95213257
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93928466
57African trypanosomiasis_Homo sapiens_hsa051430.91964906
58Olfactory transduction_Homo sapiens_hsa047400.91141725
59Dorso-ventral axis formation_Homo sapiens_hsa043200.90898573
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.89943418
61Rheumatoid arthritis_Homo sapiens_hsa053230.89401192
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.87852269
63Sulfur metabolism_Homo sapiens_hsa009200.83261765
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82182028
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79793014
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77739179
67Pancreatic cancer_Homo sapiens_hsa052120.77081903
68Collecting duct acid secretion_Homo sapiens_hsa049660.76314276
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76063738
70Autoimmune thyroid disease_Homo sapiens_hsa053200.75515185
71Type II diabetes mellitus_Homo sapiens_hsa049300.74943519
72Linoleic acid metabolism_Homo sapiens_hsa005910.74856015
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69963631
74Type I diabetes mellitus_Homo sapiens_hsa049400.69929180
75Systemic lupus erythematosus_Homo sapiens_hsa053220.68407689
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67911115
77Prolactin signaling pathway_Homo sapiens_hsa049170.67790512
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64647478
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64055348
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64013643
81Ether lipid metabolism_Homo sapiens_hsa005650.62991761
82Renin-angiotensin system_Homo sapiens_hsa046140.61572386
83Arachidonic acid metabolism_Homo sapiens_hsa005900.60890852
84Morphine addiction_Homo sapiens_hsa050320.60253189
85Mineral absorption_Homo sapiens_hsa049780.59291085
86Regulation of autophagy_Homo sapiens_hsa041400.58924512
87Salivary secretion_Homo sapiens_hsa049700.58348844
88Histidine metabolism_Homo sapiens_hsa003400.56853127
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.53512967
90Viral myocarditis_Homo sapiens_hsa054160.53106112
91Long-term depression_Homo sapiens_hsa047300.48440465
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47951691
93Nicotine addiction_Homo sapiens_hsa050330.47922439
94Renin secretion_Homo sapiens_hsa049240.47471921
95Non-small cell lung cancer_Homo sapiens_hsa052230.47461120
96Circadian entrainment_Homo sapiens_hsa047130.46688770
97Bile secretion_Homo sapiens_hsa049760.46659956
98Serotonergic synapse_Homo sapiens_hsa047260.44017025
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43514442
100Cholinergic synapse_Homo sapiens_hsa047250.43504989
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42792982
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42451259
103Steroid biosynthesis_Homo sapiens_hsa001000.42215014
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41709219
105Taste transduction_Homo sapiens_hsa047420.41269327
106Epstein-Barr virus infection_Homo sapiens_hsa051690.39778445
107Pentose phosphate pathway_Homo sapiens_hsa000300.39673488
108Nitrogen metabolism_Homo sapiens_hsa009100.39131396
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.38352763
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38180706
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37506011
112Oxytocin signaling pathway_Homo sapiens_hsa049210.37265879
113Pancreatic secretion_Homo sapiens_hsa049720.36596897
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.34620123
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34259124
116Calcium signaling pathway_Homo sapiens_hsa040200.33521657
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.32108405
118Sphingolipid metabolism_Homo sapiens_hsa006000.32036311
119Tryptophan metabolism_Homo sapiens_hsa003800.31936989
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31894334
121Ovarian steroidogenesis_Homo sapiens_hsa049130.31424568
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.30885585
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28845289
124GABAergic synapse_Homo sapiens_hsa047270.28762696
125* MAPK signaling pathway_Homo sapiens_hsa040100.27341463
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25782402
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25550901
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25541702
129Choline metabolism in cancer_Homo sapiens_hsa052310.24915739
130Endocytosis_Homo sapiens_hsa041440.22176748
131VEGF signaling pathway_Homo sapiens_hsa043700.21678578
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21322347
133Galactose metabolism_Homo sapiens_hsa000520.20457111

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