TAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.30263668
2* antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.30263668
3* antigen processing and presentation of endogenous antigen (GO:0019883)6.87629728
4positive regulation of gamma-delta T cell activation (GO:0046645)6.05174173
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.16352440
6regulation of gamma-delta T cell differentiation (GO:0045586)4.60300835
7antigen processing and presentation via MHC class Ib (GO:0002475)4.51287738
8positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.49637970
9response to type I interferon (GO:0034340)4.48649561
10cellular response to type I interferon (GO:0071357)4.44707836
11type I interferon signaling pathway (GO:0060337)4.44707836
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.41087875
13regulation of gamma-delta T cell activation (GO:0046643)4.38530547
14detection of other organism (GO:0098543)4.35338507
15detection of bacterium (GO:0016045)4.30949175
16negative thymic T cell selection (GO:0045060)4.30005741
17negative T cell selection (GO:0043383)4.25687827
18regulation of interleukin-12 biosynthetic process (GO:0045075)4.13321320
19NIK/NF-kappaB signaling (GO:0038061)4.04232539
20macrophage activation involved in immune response (GO:0002281)4.01835434
21T cell migration (GO:0072678)3.99125603
22regulation of B cell receptor signaling pathway (GO:0050855)3.98236186
23positive thymic T cell selection (GO:0045059)3.97774083
24positive regulation of B cell differentiation (GO:0045579)3.94891846
25regulation of type I interferon-mediated signaling pathway (GO:0060338)3.85568393
26interferon-gamma-mediated signaling pathway (GO:0060333)3.78565788
27regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.76263215
28response to peptidoglycan (GO:0032494)3.76225738
29regulation of dendritic cell antigen processing and presentation (GO:0002604)3.75979412
30leukocyte aggregation (GO:0070486)3.73563966
31positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.73104963
32regulation of B cell differentiation (GO:0045577)3.70618236
33response to interleukin-15 (GO:0070672)3.68887985
34negative regulation of lymphocyte mediated immunity (GO:0002707)3.68456527
35thymic T cell selection (GO:0045061)3.68051781
36immunoglobulin mediated immune response (GO:0016064)3.62569776
37positive regulation of interferon-alpha production (GO:0032727)3.60470240
38JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.58668769
39negative regulation of T cell mediated immunity (GO:0002710)3.58179077
40detection of external biotic stimulus (GO:0098581)3.55077136
41cellular response to interferon-beta (GO:0035458)3.52747037
42positive regulation of antigen processing and presentation (GO:0002579)3.50944941
43B cell receptor signaling pathway (GO:0050853)3.49542731
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.49003669
45negative regulation of cell killing (GO:0031342)3.46535770
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.46535770
47T cell selection (GO:0045058)3.46156499
48germinal center formation (GO:0002467)3.44328715
49regulation of alpha-beta T cell proliferation (GO:0046640)3.43972252
50regulation of interferon-alpha production (GO:0032647)3.43724980
51defense response to protozoan (GO:0042832)3.37284462
52regulation of tolerance induction (GO:0002643)3.37065999
53regulation of T cell mediated cytotoxicity (GO:0001914)3.34553635
54negative regulation of leukocyte mediated immunity (GO:0002704)3.33044047
55regulation of response to interferon-gamma (GO:0060330)3.32514279
56response to protozoan (GO:0001562)3.28498369
57response to interferon-beta (GO:0035456)3.28118772
58positive regulation of T cell mediated cytotoxicity (GO:0001916)3.27752378
59interferon-gamma production (GO:0032609)3.27582023
60positive regulation of natural killer cell differentiation (GO:0032825)3.27520057
61Arp2/3 complex-mediated actin nucleation (GO:0034314)3.25921788
62myeloid dendritic cell activation (GO:0001773)3.23428884
63regulation of T cell tolerance induction (GO:0002664)3.22574615
64response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.21188442
65response to host immune response (GO:0052572)3.21188442
66positive regulation of type 2 immune response (GO:0002830)3.20565707
67regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.18676645
68positive T cell selection (GO:0043368)3.18406529
69regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.16490781
70regulation of natural killer cell mediated immunity (GO:0002715)3.16490781
71regulation of interferon-beta biosynthetic process (GO:0045357)3.14587112
72regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.14300344
73cellular response to interleukin-15 (GO:0071350)3.11771213
74myeloid dendritic cell differentiation (GO:0043011)3.11014535
75negative regulation of innate immune response (GO:0045824)3.11004022
76detection of biotic stimulus (GO:0009595)3.10982192
77positive regulation of interleukin-2 production (GO:0032743)3.10761048
78positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.09935139
79detection of molecule of bacterial origin (GO:0032490)3.09574826
80regulation of antigen processing and presentation (GO:0002577)3.07578386
81response to interferon-alpha (GO:0035455)3.06695734
82B cell mediated immunity (GO:0019724)3.06594881
83tolerance induction (GO:0002507)3.05829508
84lipopolysaccharide-mediated signaling pathway (GO:0031663)3.05776157
85negative regulation of viral genome replication (GO:0045071)3.05418268
86ribosomal small subunit assembly (GO:0000028)3.05396236
87negative regulation of cytokine production involved in immune response (GO:0002719)3.03433611
88T cell costimulation (GO:0031295)3.01749853
89positive regulation of humoral immune response (GO:0002922)3.01692598
90positive regulation by organism of defense response of other organism involved in symbiotic interact3.00893774
91modulation by symbiont of host immune response (GO:0052553)3.00893774
92positive regulation by symbiont of host defense response (GO:0052509)3.00893774
93modulation by symbiont of host defense response (GO:0052031)3.00893774
94modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.00893774
95modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.00893774
96T cell homeostasis (GO:0043029)3.00371176
97response to host (GO:0075136)2.98977059
98response to host defenses (GO:0052200)2.98977059
99response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.98977059
100positive regulation of isotype switching (GO:0045830)2.98651378
101antigen receptor-mediated signaling pathway (GO:0050851)2.97819450
102response to interferon-gamma (GO:0034341)2.97385210
103regulation of RIG-I signaling pathway (GO:0039535)2.96736340
104cellular response to zinc ion (GO:0071294)2.96415113
105lymphocyte costimulation (GO:0031294)2.96404851
106regulation of T cell receptor signaling pathway (GO:0050856)2.94743328
107positive regulation of tolerance induction (GO:0002645)2.94399987
108regulation of isotype switching to IgG isotypes (GO:0048302)2.93473225
109cellular extravasation (GO:0045123)2.92912710
110cellular response to interferon-gamma (GO:0071346)2.92633768
111T-helper 1 type immune response (GO:0042088)2.91935389
112mature B cell differentiation (GO:0002335)2.91662397
113myeloid cell activation involved in immune response (GO:0002275)2.89998444
114negative regulation of erythrocyte differentiation (GO:0045647)2.89607035
115regulation of leukocyte mediated cytotoxicity (GO:0001910)2.87650718
116respiratory burst (GO:0045730)2.86910740
117regulation of regulatory T cell differentiation (GO:0045589)2.86732420
118natural killer cell differentiation (GO:0001779)2.86461378
119positive regulation of alpha-beta T cell proliferation (GO:0046641)2.85816772
120mast cell activation (GO:0045576)2.84890433
121production of molecular mediator involved in inflammatory response (GO:0002532)2.84658468
122T cell receptor signaling pathway (GO:0050852)2.84266063
123regulation of type 2 immune response (GO:0002828)2.82900915
124neutrophil activation (GO:0042119)2.80689666
125natural killer cell activation (GO:0030101)2.79617284
126leukocyte cell-cell adhesion (GO:0007159)2.79605396
127dendritic cell chemotaxis (GO:0002407)2.79506220
128response to muramyl dipeptide (GO:0032495)2.77901637
129lymphocyte homeostasis (GO:0002260)2.75880601
130regulation of interleukin-2 biosynthetic process (GO:0045076)2.75455344
131negative regulation of phagocytosis (GO:0050765)2.74234904
132positive regulation of immunoglobulin mediated immune response (GO:0002891)2.73845997
133positive regulation of B cell mediated immunity (GO:0002714)2.73845997
134regulation of T-helper 1 cell differentiation (GO:0045625)2.70399814
135viral transcription (GO:0019083)2.69725246
136positive regulation of interferon-beta production (GO:0032728)2.66093366
137negative regulation of interleukin-12 production (GO:0032695)2.64941488
138regulation of natural killer cell differentiation (GO:0032823)2.61927889
139neutrophil activation involved in immune response (GO:0002283)2.61575114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human5.62434068
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.71032105
3* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.23762002
4* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.08504507
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.06539849
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.02745939
7E2F7_22180533_ChIP-Seq_HELA_Human3.45192432
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.21716658
9MYC_22102868_ChIP-Seq_BL_Human2.93584431
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.91069860
11* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.87449016
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.79458940
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.76557175
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.70863722
15VDR_21846776_ChIP-Seq_THP-1_Human2.60689814
16MYB_26560356_Chip-Seq_TH2_Human2.53995417
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53384928
18MAF_26560356_Chip-Seq_TH1_Human2.52508223
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52157426
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.46030134
21RUNX_20019798_ChIP-Seq_JUKART_Human2.36017319
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.35029045
23SCL_19346495_ChIP-Seq_HPC-7_Human2.31587040
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28341402
25* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28046873
26MYB_26560356_Chip-Seq_TH1_Human2.25260672
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.23970867
28BP1_19119308_ChIP-ChIP_Hs578T_Human2.17223404
29SPI1_23547873_ChIP-Seq_NB4_Human2.07764866
30UTX_26944678_Chip-Seq_JUKART_Human2.04722082
31VDR_24763502_ChIP-Seq_THP-1_Human1.97393741
32GATA1_22025678_ChIP-Seq_K562_Human1.95494514
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95321476
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.92191285
35* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.91320147
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.91172574
37TCF7_22412390_ChIP-Seq_EML_Mouse1.82183688
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81428861
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.81348375
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78289885
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78009594
42MAF_26560356_Chip-Seq_TH2_Human1.66597873
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.62440312
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61546317
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60221225
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57175200
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.53476057
48GATA3_27048872_Chip-Seq_THYMUS_Human1.49259486
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46695397
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46090701
51SPI1_23127762_ChIP-Seq_K562_Human1.45450192
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.43990473
53VDR_24787735_ChIP-Seq_THP-1_Human1.41626496
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40189374
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39198460
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38998827
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36578470
58* ELK3_25401928_ChIP-Seq_HUVEC_Human1.34920859
59PU_27001747_Chip-Seq_BMDM_Mouse1.33268484
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33236177
61KDM2B_26808549_Chip-Seq_DND41_Human1.31052056
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31038884
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26453209
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25424794
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23037669
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19178880
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17451613
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16416211
69CIITA_25753668_ChIP-Seq_RAJI_Human1.15255714
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10146909
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09799527
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09386062
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08885031
74GATA3_26560356_Chip-Seq_TH2_Human1.08760788
75* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07042406
76BCOR_27268052_Chip-Seq_Bcells_Human1.04565613
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04126069
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00877135
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.00352101
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00008243
81GATA1_19941826_ChIP-Seq_K562_Human0.99465351
82HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98579578
83PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98433418
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97738703
85GATA1_19941827_ChIP-Seq_MEL_Mouse0.97481888
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96846928
87FOXM1_23109430_ChIP-Seq_U2OS_Human0.94606480
88* RACK7_27058665_Chip-Seq_MCF-7_Human0.94586446
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94574502
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94491205
91CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90097488
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88866151
93CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88837308
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86737191
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85517318
96NCOR1_26117541_ChIP-Seq_K562_Human0.84794573
97STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84572779
98LXR_22292898_ChIP-Seq_THP-1_Human0.84542573
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.82499531
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82391318
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82250481
102* VDR_23849224_ChIP-Seq_CD4+_Human0.82175155
103PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80364102
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.78027384
105SA1_27219007_Chip-Seq_ERYTHROID_Human0.77947107
106GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77540475
107PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76616689
108PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76548515
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75541864
110E2F4_17652178_ChIP-ChIP_JURKAT_Human0.73710054
111FOXP3_21729870_ChIP-Seq_TREG_Human0.72726365
112BCL6_27268052_Chip-Seq_Bcells_Human0.72676325
113CTCF_26484167_Chip-Seq_Bcells_Mouse0.72242470
114PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.69900860
115TFEB_21752829_ChIP-Seq_HELA_Human0.69310991
116P300_27268052_Chip-Seq_Bcells_Human0.68911196
117KDM2B_26808549_Chip-Seq_JURKAT_Human0.68784013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.44520275
2MP0000685_abnormal_immune_system3.68512055
3MP0005671_abnormal_response_to3.36205002
4MP0001790_abnormal_immune_system3.22779563
5MP0005387_immune_system_phenotype3.22779563
6MP0001800_abnormal_humoral_immune3.14498658
7MP0003763_abnormal_thymus_physiology3.06913799
8* MP0009785_altered_susceptibility_to3.00402538
9MP0003436_decreased_susceptibility_to2.93104522
10MP0005000_abnormal_immune_tolerance2.85479781
11MP0002166_altered_tumor_susceptibility2.79092679
12* MP0005025_abnormal_response_to2.71271671
13* MP0002452_abnormal_antigen_presenting2.70960768
14MP0002723_abnormal_immune_serum2.67716337
15* MP0002420_abnormal_adaptive_immunity2.55680016
16* MP0001819_abnormal_immune_cell2.54566341
17MP0003303_peritoneal_inflammation2.47265438
18MP0002148_abnormal_hypersensitivity_rea2.39628565
19* MP0002398_abnormal_bone_marrow2.36019336
20MP0003724_increased_susceptibility_to2.33907130
21MP0002419_abnormal_innate_immunity2.29798272
22MP0002006_tumorigenesis2.29590678
23MP0002396_abnormal_hematopoietic_system2.27017944
24* MP0000716_abnormal_immune_system2.16193549
25MP0004947_skin_inflammation2.15836429
26MP0004510_myositis2.14939640
27MP0006082_CNS_inflammation2.08862322
28MP0003300_gastrointestinal_ulcer2.08782623
29MP0010155_abnormal_intestine_physiology2.07732423
30MP0002405_respiratory_system_inflammati2.04475207
31MP0001873_stomach_inflammation2.03492718
32MP0005464_abnormal_platelet_physiology2.00351193
33MP0001853_heart_inflammation1.99921065
34MP0009333_abnormal_splenocyte_physiolog1.99855145
35MP0000689_abnormal_spleen_morphology1.96300802
36MP0002722_abnormal_immune_system1.91293294
37MP0005451_abnormal_body_composition1.85441728
38* MP0002429_abnormal_blood_cell1.82142562
39MP0001845_abnormal_inflammatory_respons1.77873078
40MP0004808_abnormal_hematopoietic_stem1.65472807
41MP0000703_abnormal_thymus_morphology1.63783350
42MP0003866_abnormal_defecation1.62219169
43MP0001545_abnormal_hematopoietic_system1.57651177
44MP0005397_hematopoietic_system_phenotyp1.57651177
45MP0000465_gastrointestinal_hemorrhage1.45080543
46MP0008469_abnormal_protein_level1.43372934
47MP0001533_abnormal_skeleton_physiology1.43021652
48MP0009278_abnormal_bone_marrow1.41999112
49MP0008260_abnormal_autophagy1.36118065
50MP0005310_abnormal_salivary_gland1.32188022
51MP0002254_reproductive_system_inflammat1.31654425
52MP0010352_gastrointestinal_tract_polyps1.29318644
53MP0003191_abnormal_cellular_cholesterol1.28779120
54MP0000858_altered_metastatic_potential1.27108696
55MP0003448_altered_tumor_morphology1.27101094
56MP0009764_decreased_sensitivity_to1.20204786
57MP0002933_joint_inflammation1.18989546
58MP0002138_abnormal_hepatobiliary_system1.18819305
59MP0000490_abnormal_crypts_of1.12813612
60MP0009840_abnormal_foam_cell1.08643307
61MP0005058_abnormal_lysosome_morphology1.02492118
62MP0002019_abnormal_tumor_incidence0.99252055
63MP0002277_abnormal_respiratory_mucosa0.98684889
64MP0005174_abnormal_tail_pigmentation0.98495713
65MP0003806_abnormal_nucleotide_metabolis0.96559481
66MP0003453_abnormal_keratinocyte_physiol0.96466505
67MP0005023_abnormal_wound_healing0.92009078
68MP0001851_eye_inflammation0.91610747
69MP0000343_altered_response_to0.88063072
70MP0009763_increased_sensitivity_to0.87934653
71MP0004883_abnormal_blood_vessel0.87510693
72MP0005164_abnormal_response_to0.87285668
73MP0005075_abnormal_melanosome_morpholog0.84976656
74MP0008004_abnormal_stomach_pH0.84783568
75MP0003172_abnormal_lysosome_physiology0.84388850
76MP0010307_abnormal_tumor_latency0.83214737
77MP0002998_abnormal_bone_remodeling0.82342088
78MP0003566_abnormal_cell_adhesion0.79550635
79MP0004381_abnormal_hair_follicle0.73144822
80MP0005076_abnormal_cell_differentiation0.72316082
81MP0000609_abnormal_liver_physiology0.70924920
82MP0001216_abnormal_epidermal_layer0.70764477
83MP0003690_abnormal_glial_cell0.70439546
84MP0010234_abnormal_vibrissa_follicle0.68384047
85MP0003795_abnormal_bone_structure0.67886520
86MP0002139_abnormal_hepatobiliary_system0.67709575
87MP0003183_abnormal_peptide_metabolism0.66431657
88MP0008874_decreased_physiological_sensi0.65496038
89MP0000604_amyloidosis0.64724024
90MP0002136_abnormal_kidney_physiology0.64544179
91MP0009765_abnormal_xenobiotic_induced0.64149743
92MP0001663_abnormal_digestive_system0.63966913
93MP0006054_spinal_hemorrhage0.62354048
94MP0002332_abnormal_exercise_endurance0.62184617
95MP0003045_fibrosis0.61969825
96MP0000249_abnormal_blood_vessel0.60778603
97MP0002132_abnormal_respiratory_system0.60266098
98MP0003828_pulmonary_edema0.60053656
99MP0003693_abnormal_embryo_hatching0.59933149
100MP0005166_decreased_susceptibility_to0.59700261
101MP0008057_abnormal_DNA_replication0.58493337
102MP0002095_abnormal_skin_pigmentation0.58412423
103MP0001348_abnormal_lacrimal_gland0.58062870
104MP0002009_preneoplasia0.57486853
105MP0005390_skeleton_phenotype0.55846132
106MP0009931_abnormal_skin_appearance0.55567219
107MP0003075_altered_response_to0.55476214
108MP0003091_abnormal_cell_migration0.55212172
109MP0005381_digestive/alimentary_phenotyp0.55079226
110MP0001191_abnormal_skin_condition0.54953405
111MP0000598_abnormal_liver_morphology0.54067599
112MP0003077_abnormal_cell_cycle0.53730876
113MP0000477_abnormal_intestine_morphology0.53208674
114MP0002877_abnormal_melanocyte_morpholog0.50091324
115MP0002693_abnormal_pancreas_physiology0.49110900
116MP0003329_amyloid_beta_deposits0.48703000
117MP0005319_abnormal_enzyme/_coenzyme0.48374847

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.21721353
2Eczematoid dermatitis (HP:0000976)4.88719746
3* Chronic otitis media (HP:0000389)4.67916123
4Recurrent viral infections (HP:0004429)4.59938354
5Recurrent abscess formation (HP:0002722)4.46873026
6Recurrent fungal infections (HP:0002841)4.37473495
7Myositis (HP:0100614)4.24199187
8* Recurrent bronchitis (HP:0002837)4.22434965
9Recurrent bacterial skin infections (HP:0005406)4.12184003
10IgM deficiency (HP:0002850)4.03703854
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.96316127
12Panhypogammaglobulinemia (HP:0003139)3.79623499
13* Nasal polyposis (HP:0100582)3.76562471
14Chronic mucocutaneous candidiasis (HP:0002728)3.75140177
15Recurrent cutaneous fungal infections (HP:0011370)3.75140177
16T lymphocytopenia (HP:0005403)3.75093725
17Abnormality of T cell number (HP:0011839)3.71659200
18Abnormality of T cells (HP:0002843)3.69622081
19Agammaglobulinemia (HP:0004432)3.65586233
20Autoimmune thrombocytopenia (HP:0001973)3.59527453
21Thrombocytosis (HP:0001894)3.55560850
22Pustule (HP:0200039)3.49540738
23Inflammation of the large intestine (HP:0002037)3.48966213
24* Abnormality of the nasal mucosa (HP:0000433)3.48685329
25Vasculitis (HP:0002633)3.48144855
26Abnormality of T cell physiology (HP:0011840)3.47410627
27Increased IgE level (HP:0003212)3.46249974
28Gastrointestinal inflammation (HP:0004386)3.42980698
29Recurrent skin infections (HP:0001581)3.42827203
30Cellulitis (HP:0100658)3.41349664
31Colitis (HP:0002583)3.41030357
32Meningitis (HP:0001287)3.39573910
33Mediastinal lymphadenopathy (HP:0100721)3.36536456
34Interstitial pulmonary disease (HP:0006530)3.20275316
35Stomatitis (HP:0010280)3.18408098
36Lymphopenia (HP:0001888)3.10926357
37Spontaneous hematomas (HP:0007420)3.07688817
38Abnormality of cells of the lymphoid lineage (HP:0012140)3.04952058
39Hypergammaglobulinemia (HP:0010702)2.97726911
40Orchitis (HP:0100796)2.96979550
41IgG deficiency (HP:0004315)2.96085923
42Abnormality of the fingertips (HP:0001211)2.93428429
43Gastrointestinal stroma tumor (HP:0100723)2.91425899
44Recurrent gram-negative bacterial infections (HP:0005420)2.87263444
45Abnormality of macrophages (HP:0004311)2.86966108
46Systemic lupus erythematosus (HP:0002725)2.85718832
47Petechiae (HP:0000967)2.84066315
48B lymphocytopenia (HP:0010976)2.80410211
49Abnormality of B cell number (HP:0010975)2.80410211
50Eosinophilia (HP:0001880)2.72525527
51Chronic obstructive pulmonary disease (HP:0006510)2.72179652
52Obstructive lung disease (HP:0006536)2.72179652
53Optic neuritis (HP:0100653)2.71507607
54Retrobulbar optic neuritis (HP:0100654)2.71507607
55Increased IgM level (HP:0003496)2.68372315
56IgA deficiency (HP:0002720)2.67830501
57Gangrene (HP:0100758)2.67700104
58Recurrent sinusitis (HP:0011108)2.67070537
59Gingival bleeding (HP:0000225)2.66124971
60Severe combined immunodeficiency (HP:0004430)2.63292546
61Chronic diarrhea (HP:0002028)2.62308239
62Periodontitis (HP:0000704)2.61937659
63Combined immunodeficiency (HP:0005387)2.61910399
64Autoimmune hemolytic anemia (HP:0001890)2.61481902
65Leukocytosis (HP:0001974)2.61294324
66Verrucae (HP:0200043)2.61088282
67Papilloma (HP:0012740)2.61088282
68Granulocytopenia (HP:0001913)2.60900403
69Hemoptysis (HP:0002105)2.57056355
70Abnormality of glycolipid metabolism (HP:0010969)2.56610081
71Abnormality of liposaccharide metabolism (HP:0010968)2.56610081
72Abnormality of glycosphingolipid metabolism (HP:0004343)2.56610081
73Prolonged bleeding time (HP:0003010)2.56349328
74Pulmonary embolism (HP:0002204)2.54801731
75Pulmonary infiltrates (HP:0002113)2.54639289
76Epistaxis (HP:0000421)2.52602453
77Abnormality of the pleura (HP:0002103)2.51972910
78Anorexia (HP:0002039)2.48522394
79Abnormality of eosinophils (HP:0001879)2.47600650
80Encephalitis (HP:0002383)2.47290500
81Thyroiditis (HP:0100646)2.46060875
82* Emphysema (HP:0002097)2.44658061
83Arterial thrombosis (HP:0004420)2.44506612
84Malnutrition (HP:0004395)2.42042851
85Osteomyelitis (HP:0002754)2.41351286
86* Skin ulcer (HP:0200042)2.41282994
87Gingivitis (HP:0000230)2.39548843
88* Chronic sinusitis (HP:0011109)2.38397385
89Lymphoma (HP:0002665)2.31977160
90Hematochezia (HP:0002573)2.30952441
91Premature loss of primary teeth (HP:0006323)2.30534976
92Chest pain (HP:0100749)2.26900882
93Gastrointestinal infarctions (HP:0005244)2.26712098
94* Bronchitis (HP:0012387)2.24575180
95Joint swelling (HP:0001386)2.22270476
96Glomerulopathy (HP:0100820)2.21890172
97Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16613080
98Restrictive lung disease (HP:0002091)2.16229201
99Basal ganglia calcification (HP:0002135)2.15405169
100Arthralgia (HP:0002829)2.12287566
101Abnormal platelet volume (HP:0011876)2.11793245
102Peritonitis (HP:0002586)2.11361321
103Abnormality of the pericardium (HP:0001697)2.09659132
104Amyloidosis (HP:0011034)2.09018088
105Hypochromic anemia (HP:0001931)2.06899624
106Abnormality of cells of the erythroid lineage (HP:0012130)2.06661901
107Episodic fever (HP:0001954)2.05468916
108Abnormal platelet function (HP:0011869)2.05369215
109Impaired platelet aggregation (HP:0003540)2.05369215
110Abnormality of the endocardium (HP:0004306)2.05364047
111Keratoconjunctivitis sicca (HP:0001097)2.04752179
112Skin rash (HP:0000988)2.03803074
113Abnormality of the peritoneum (HP:0002585)2.03796486
114Urticaria (HP:0001025)2.02881436
115Polyneuropathy (HP:0001271)2.01049755
116Cheilitis (HP:0100825)1.99362982
117Keratitis (HP:0000491)1.98671424
118Recurrent lower respiratory tract infections (HP:0002783)1.98620922
119Increased serum ferritin (HP:0003281)1.98170818
120Sepsis (HP:0100806)1.97835332
121Dysostosis multiplex (HP:0000943)1.97715641
122Purpura (HP:0000979)1.97027790
123Keratoconjunctivitis (HP:0001096)1.96483057
124Loss of speech (HP:0002371)1.95832055
125Fatigue (HP:0012378)1.95665282

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.04021521
2TYK23.57788869
3JAK33.34590152
4PRPF4B2.86802200
5IKBKE2.81895914
6FGFR42.78283157
7TXK2.68612422
8KIT2.66176248
9TBK12.64227539
10MAP3K142.61990539
11BLK2.54681737
12ZAP702.33017985
13JAK12.31652257
14ERN12.18342361
15EEF2K2.11759157
16STK101.96078208
17BTK1.95292876
18IKBKB1.77427009
19MAP3K101.76516268
20ITK1.76248169
21IRAK41.75546619
22GRK61.74264705
23SYK1.73250033
24CSF1R1.71226255
25FGFR31.70068400
26TEC1.64973535
27NME21.61571278
28MAP3K131.61135662
29LRRK21.52350938
30LCK1.47241112
31FLT31.42984328
32TAOK11.42680990
33EPHB11.41308310
34CSK1.38065493
35TAOK21.36532870
36NLK1.33935772
37FGR1.33688723
38HCK1.31022213
39PKN21.24491426
40TRIB31.20341005
41RPS6KA41.20199505
42SMG11.19952143
43TGFBR21.18269696
44MST41.14167498
45EPHA31.13968144
46KDR1.13763999
47PIM11.13188396
48RIPK41.12582044
49PIM21.11508675
50CHUK1.09926498
51BMPR21.08999905
52CDC42BPA1.06029497
53JAK21.03528400
54MAP2K31.00117637
55LYN0.99479669
56IRAK30.97122514
57FES0.95567243
58CLK10.95348450
59GRK70.94611048
60TAOK30.90641803
61MARK30.82958427
62KSR20.75210032
63TGFBR10.73198403
64PTK60.70962321
65SIK20.66839343
66PRKCQ0.65778690
67CDK40.62222896
68RPS6KB20.62205076
69MAPK110.59951940
70PRKD20.59645013
71PDPK10.58751840
72MAPK70.57341143
73STK40.57273816
74IRAK20.55715772
75MAP3K50.54525448
76YES10.52935002
77HIPK20.52711312
78TTN0.51853880
79SIK10.51365347
80MARK20.50930119
81FYN0.50788040
82NEK90.50011419
83TESK20.49791751
84MAP3K70.48245170
85MAP2K60.48034065
86MATK0.46781869
87CDK120.44874425
88MAPK120.44065941
89MAP3K80.44064481
90TNK20.43756630
91MAP3K110.43537314
92NEK20.42741693
93MAPKAPK30.42675355
94MAPK40.41305948
95CDK60.41048844
96MAP3K30.40536637
97SCYL20.40448661
98MOS0.40154104
99TRPM70.39739364
100PRKCH0.39736087
101IRAK10.39348986
102ABL10.37861416
103RPS6KA60.37604119
104RPS6KA50.37559790
105PDK10.36593936
106MAPKAPK20.35849335
107MAP3K60.35844542
108EGFR0.35148939
109DDR20.34061811
110ALK0.29463513
111SIK30.28036514
112PIK3CG0.27787096
113RET0.26945571
114PRKCD0.26334485
115DYRK1B0.25561394
116MAPK30.24957480
117STK240.23980858
118CAMKK10.23413774
119RPS6KC10.23371003
120RPS6KL10.23371003
121PASK0.22405406
122MAP3K10.21861734
123ATR0.20952848
124MST1R0.20680650
125RIPK10.20549122
126CDK90.20535488

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053403.89617718
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.84747959
3Measles_Homo sapiens_hsa051622.73411534
4Leishmaniasis_Homo sapiens_hsa051402.73215802
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.69678266
6B cell receptor signaling pathway_Homo sapiens_hsa046622.50780093
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.45660436
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.37012682
9Allograft rejection_Homo sapiens_hsa053302.34356565
10* Antigen processing and presentation_Homo sapiens_hsa046122.31491614
11Osteoclast differentiation_Homo sapiens_hsa043802.25226173
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.20193287
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09903385
14T cell receptor signaling pathway_Homo sapiens_hsa046602.08747788
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.04124838
16Hematopoietic cell lineage_Homo sapiens_hsa046401.98278771
17* Herpes simplex infection_Homo sapiens_hsa051681.97571651
18Graft-versus-host disease_Homo sapiens_hsa053321.91453630
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.90774962
20Influenza A_Homo sapiens_hsa051641.78449984
21Toxoplasmosis_Homo sapiens_hsa051451.76936883
22Staphylococcus aureus infection_Homo sapiens_hsa051501.63794513
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62882589
24Legionellosis_Homo sapiens_hsa051341.56027290
25Viral myocarditis_Homo sapiens_hsa054161.51339669
26Ribosome_Homo sapiens_hsa030101.50937638
27TNF signaling pathway_Homo sapiens_hsa046681.48246503
28Pertussis_Homo sapiens_hsa051331.48027058
29Malaria_Homo sapiens_hsa051441.47730832
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47372917
31Acute myeloid leukemia_Homo sapiens_hsa052211.43958967
32Hepatitis B_Homo sapiens_hsa051611.43459166
33Apoptosis_Homo sapiens_hsa042101.41926339
34Tuberculosis_Homo sapiens_hsa051521.36037581
35Shigellosis_Homo sapiens_hsa051311.33178150
36Chemokine signaling pathway_Homo sapiens_hsa040621.31691603
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30634030
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28150039
39Asthma_Homo sapiens_hsa053101.27490193
40Autoimmune thyroid disease_Homo sapiens_hsa053201.25416765
41Hepatitis C_Homo sapiens_hsa051601.24164651
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23311864
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.22373013
44DNA replication_Homo sapiens_hsa030301.12688846
45* Phagosome_Homo sapiens_hsa041451.05982519
46Chronic myeloid leukemia_Homo sapiens_hsa052201.03697348
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97240494
48Caffeine metabolism_Homo sapiens_hsa002320.94310583
49Platelet activation_Homo sapiens_hsa046110.93655253
50Pancreatic cancer_Homo sapiens_hsa052120.91761437
51Salmonella infection_Homo sapiens_hsa051320.91472682
52Epstein-Barr virus infection_Homo sapiens_hsa051690.91167969
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88641980
54Small cell lung cancer_Homo sapiens_hsa052220.86560360
55Base excision repair_Homo sapiens_hsa034100.86048631
56Prolactin signaling pathway_Homo sapiens_hsa049170.86000590
57Viral carcinogenesis_Homo sapiens_hsa052030.85580723
58Type I diabetes mellitus_Homo sapiens_hsa049400.83504235
59HTLV-I infection_Homo sapiens_hsa051660.83410343
60African trypanosomiasis_Homo sapiens_hsa051430.82349029
61Other glycan degradation_Homo sapiens_hsa005110.81572181
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79001951
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78860677
64p53 signaling pathway_Homo sapiens_hsa041150.74200844
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72898766
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65487450
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.62879387
68VEGF signaling pathway_Homo sapiens_hsa043700.56692222
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.56288753
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.55976603
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53746597
72Non-small cell lung cancer_Homo sapiens_hsa052230.53316360
73Notch signaling pathway_Homo sapiens_hsa043300.52966057
74Mismatch repair_Homo sapiens_hsa034300.51610636
75Rheumatoid arthritis_Homo sapiens_hsa053230.50686154
76Insulin resistance_Homo sapiens_hsa049310.48408259
77Pentose phosphate pathway_Homo sapiens_hsa000300.47776531
78Lysosome_Homo sapiens_hsa041420.45850267
79Renal cell carcinoma_Homo sapiens_hsa052110.43349245
80Non-homologous end-joining_Homo sapiens_hsa034500.42149986
81HIF-1 signaling pathway_Homo sapiens_hsa040660.40598599
82Bladder cancer_Homo sapiens_hsa052190.37115778
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35522860
84Sulfur relay system_Homo sapiens_hsa041220.34136447
85Prion diseases_Homo sapiens_hsa050200.33522494
86Colorectal cancer_Homo sapiens_hsa052100.32831522
87Amoebiasis_Homo sapiens_hsa051460.32565974
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.32552776
89Dorso-ventral axis formation_Homo sapiens_hsa043200.31217939
90Systemic lupus erythematosus_Homo sapiens_hsa053220.30318220
91MicroRNAs in cancer_Homo sapiens_hsa052060.29956638
92One carbon pool by folate_Homo sapiens_hsa006700.29562453
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29420752
94Homologous recombination_Homo sapiens_hsa034400.27728927
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27447840
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27436867
97GnRH signaling pathway_Homo sapiens_hsa049120.27312788
98Endometrial cancer_Homo sapiens_hsa052130.26255986
99Spliceosome_Homo sapiens_hsa030400.26172629
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25804314
101MAPK signaling pathway_Homo sapiens_hsa040100.25149664
102Type II diabetes mellitus_Homo sapiens_hsa049300.24019801
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.23527711
104Fructose and mannose metabolism_Homo sapiens_hsa000510.22886941
105FoxO signaling pathway_Homo sapiens_hsa040680.22408690
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21691307
107Prostate cancer_Homo sapiens_hsa052150.20940382
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20683780
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20507590
110Choline metabolism in cancer_Homo sapiens_hsa052310.20354633
111Complement and coagulation cascades_Homo sapiens_hsa046100.19715388
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19474350
113Endocytosis_Homo sapiens_hsa041440.19185640
114Proteoglycans in cancer_Homo sapiens_hsa052050.19053015
115mTOR signaling pathway_Homo sapiens_hsa041500.17709194
116Galactose metabolism_Homo sapiens_hsa000520.17225115
117Pathways in cancer_Homo sapiens_hsa052000.16816974
118Proteasome_Homo sapiens_hsa030500.16339010
119Inositol phosphate metabolism_Homo sapiens_hsa005620.14358047

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