TAPBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.46611820
2* antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.46611820
3* antigen processing and presentation of endogenous antigen (GO:0019883)6.18790952
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.12573060
5negative regulation of cell killing (GO:0031342)5.12573060
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.97819719
7positive regulation of gamma-delta T cell activation (GO:0046645)4.62469446
8response to type I interferon (GO:0034340)4.42708561
9cellular response to type I interferon (GO:0071357)4.41068238
10type I interferon signaling pathway (GO:0060337)4.41068238
11positive regulation of interferon-alpha production (GO:0032727)4.14566956
12positive regulation of antigen processing and presentation (GO:0002579)4.05552586
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.97922617
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.97922617
15modulation by symbiont of host immune response (GO:0052553)3.97922617
16positive regulation by symbiont of host defense response (GO:0052509)3.97922617
17modulation by symbiont of host defense response (GO:0052031)3.97922617
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.97922617
19regulation of interferon-alpha production (GO:0032647)3.95814137
20regulation of interleukin-12 biosynthetic process (GO:0045075)3.84307889
21antigen processing and presentation via MHC class Ib (GO:0002475)3.83393923
22positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.80698460
23regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.72183942
24regulation of interferon-beta biosynthetic process (GO:0045357)3.67094082
25interferon-gamma-mediated signaling pathway (GO:0060333)3.65661367
26immunoglobulin mediated immune response (GO:0016064)3.65488197
27cellular response to interleukin-15 (GO:0071350)3.64246105
28lymphocyte chemotaxis (GO:0048247)3.58568911
29regulation of antigen processing and presentation (GO:0002577)3.57627429
30detection of bacterium (GO:0016045)3.56552014
31neutrophil activation involved in immune response (GO:0002283)3.52789559
32NIK/NF-kappaB signaling (GO:0038061)3.51705523
33regulation of dendritic cell antigen processing and presentation (GO:0002604)3.47229920
34detection of other organism (GO:0098543)3.46680624
35JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.42607131
36positive regulation of natural killer cell differentiation (GO:0032825)3.40761989
37regulation of gamma-delta T cell activation (GO:0046643)3.37201257
38regulation of type I interferon-mediated signaling pathway (GO:0060338)3.35156925
39regulation of gamma-delta T cell differentiation (GO:0045586)3.34570862
40positive regulation of T cell mediated cytotoxicity (GO:0001916)3.32470563
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.29410964
42regulation of natural killer cell mediated immunity (GO:0002715)3.29106319
43regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.29106319
44response to peptidoglycan (GO:0032494)3.28438012
45lymphocyte migration (GO:0072676)3.27963889
46cellular response to interferon-beta (GO:0035458)3.26152889
47response to muramyl dipeptide (GO:0032495)3.26123964
48response to interferon-beta (GO:0035456)3.19333819
49respiratory burst (GO:0045730)3.18792361
50regulation of T cell mediated cytotoxicity (GO:0001914)3.18457033
51regulation of B cell receptor signaling pathway (GO:0050855)3.17484169
52tolerance induction (GO:0002507)3.15520239
53response to interferon-alpha (GO:0035455)3.14265187
54myeloid dendritic cell differentiation (GO:0043011)3.10296683
55T cell migration (GO:0072678)3.08489413
56macrophage activation involved in immune response (GO:0002281)3.06261198
57negative thymic T cell selection (GO:0045060)3.03802314
58myeloid dendritic cell activation (GO:0001773)3.01906558
59negative regulation of lymphocyte mediated immunity (GO:0002707)3.01755717
60positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.98672780
61positive regulation of interferon-beta production (GO:0032728)2.97349483
62cellular response to zinc ion (GO:0071294)2.97274210
63lipopolysaccharide-mediated signaling pathway (GO:0031663)2.97138296
64regulation of leukocyte mediated cytotoxicity (GO:0001910)2.95250150
65regulation of response to interferon-gamma (GO:0060330)2.95050789
66negative T cell selection (GO:0043383)2.93722456
67leukocyte aggregation (GO:0070486)2.92506987
68detection of external biotic stimulus (GO:0098581)2.91632300
69regulation of regulatory T cell differentiation (GO:0045589)2.91298909
70positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.91159985
71negative regulation of leukocyte mediated immunity (GO:0002704)2.90634182
72regulation of T cell tolerance induction (GO:0002664)2.89754905
73T-helper 1 type immune response (GO:0042088)2.89116749
74positive regulation of interleukin-12 production (GO:0032735)2.88639587
75positive thymic T cell selection (GO:0045059)2.87733314
76negative regulation of viral genome replication (GO:0045071)2.87221097
77regulation of alpha-beta T cell proliferation (GO:0046640)2.86933872
78regulation of T-helper 1 cell differentiation (GO:0045625)2.85621096
79Arp2/3 complex-mediated actin nucleation (GO:0034314)2.85168367
80maturation of SSU-rRNA (GO:0030490)2.84345828
81defense response to protozoan (GO:0042832)2.84300353
82neutrophil activation (GO:0042119)2.83456716
83positive regulation of B cell differentiation (GO:0045579)2.83274040
84response to host immune response (GO:0052572)2.83118647
85response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.83118647
86cellular response to interferon-gamma (GO:0071346)2.82542241
87negative regulation of innate immune response (GO:0045824)2.82268675
88granulocyte activation (GO:0036230)2.80948339
89B cell mediated immunity (GO:0019724)2.79265914
90regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.75918414
91response to protozoan (GO:0001562)2.74035875
92regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.73599417
93regulation of B cell differentiation (GO:0045577)2.73403286
94regulation of RIG-I signaling pathway (GO:0039535)2.71403212
95positive regulation of natural killer cell mediated immunity (GO:0002717)2.70730032
96regulation of cell killing (GO:0031341)2.70729566
97regulation of cholesterol storage (GO:0010885)2.69405169
98positive regulation of cell killing (GO:0031343)2.69366771
99mast cell activation (GO:0045576)2.68012778
100positive regulation of humoral immune response (GO:0002922)2.66078313
101dendritic cell differentiation (GO:0097028)2.65975721
102leukocyte cell-cell adhesion (GO:0007159)2.65057796
103response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.62644918
104response to host (GO:0075136)2.62644918
105response to host defenses (GO:0052200)2.62644918
106cellular response to virus (GO:0098586)2.62321619
107regulation of interleukin-12 production (GO:0032655)2.61623923
108natural killer cell mediated immunity (GO:0002228)2.61387018
109natural killer cell mediated cytotoxicity (GO:0042267)2.61387018
110response to interferon-gamma (GO:0034341)2.61106361
111cellular response to exogenous dsRNA (GO:0071360)2.59570535
112low-density lipoprotein particle clearance (GO:0034383)2.55826113
113thymic T cell selection (GO:0045061)2.54687563
114cellular extravasation (GO:0045123)2.54086381
115regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.53837861
116adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.53646983
117detection of biotic stimulus (GO:0009595)2.53519478
118positive regulation of alpha-beta T cell proliferation (GO:0046641)2.53095742
119T cell costimulation (GO:0031295)2.52861163
120I-kappaB phosphorylation (GO:0007252)2.52266511
121regulation of natural killer cell differentiation (GO:0032823)2.51262373
122myeloid cell activation involved in immune response (GO:0002275)2.50792858
123negative regulation of T cell mediated immunity (GO:0002710)2.50411347
124diol metabolic process (GO:0034311)2.50264391
125lymphocyte costimulation (GO:0031294)2.49420331
126hydrogen peroxide biosynthetic process (GO:0050665)2.49223123
127positive regulation of immunoglobulin mediated immune response (GO:0002891)2.49205531
128positive regulation of B cell mediated immunity (GO:0002714)2.49205531
129negative regulation of phagocytosis (GO:0050765)2.48899160
130negative regulation of interleukin-12 production (GO:0032695)2.48639526
131JAK-STAT cascade (GO:0007259)2.48155287
132positive regulation of defense response to virus by host (GO:0002230)2.47140761
133negative regulation of cytokine production involved in immune response (GO:0002719)2.47130011
134negative regulation of stress fiber assembly (GO:0051497)2.46946310
135T cell selection (GO:0045058)2.46788049
136response to interleukin-15 (GO:0070672)2.44909204
137regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.44791899
138natural killer cell differentiation (GO:0001779)2.44160094
139positive regulation of cytokine biosynthetic process (GO:0042108)2.42960736

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human6.20388021
2* IRF8_21731497_ChIP-ChIP_J774_Mouse4.71968928
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.34271447
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.07087697
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.04697210
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.54353728
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.25770106
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.15038827
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.99687645
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91873481
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91352436
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.63732566
13* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.62308740
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.61922668
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.60641620
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.58640640
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50558988
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.48637833
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43601241
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.24342478
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.17369334
22MYB_26560356_Chip-Seq_TH2_Human2.10998532
23GATA1_22025678_ChIP-Seq_K562_Human2.10078647
24* MAF_26560356_Chip-Seq_TH1_Human2.08438055
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.01715858
26RUNX_20019798_ChIP-Seq_JUKART_Human2.00951193
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96893807
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93595673
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.91039275
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.89044558
31VDR_21846776_ChIP-Seq_THP-1_Human1.87653212
32SPI1_23547873_ChIP-Seq_NB4_Human1.81746468
33MYB_26560356_Chip-Seq_TH1_Human1.78453542
34VDR_24763502_ChIP-Seq_THP-1_Human1.75880885
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74284563
36MYC_22102868_ChIP-Seq_BL_Human1.72820474
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.67714722
38SCL_19346495_ChIP-Seq_HPC-7_Human1.65867754
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59829656
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.59520348
41UTX_26944678_Chip-Seq_JUKART_Human1.59489346
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58712498
43SPI1_23127762_ChIP-Seq_K562_Human1.51345311
44* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48768088
45PPARA_22158963_ChIP-Seq_LIVER_Mouse1.48605003
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44805364
47CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41828687
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.41585182
49* TCF7_22412390_ChIP-Seq_EML_Mouse1.39691838
50GATA3_27048872_Chip-Seq_THYMUS_Human1.39227399
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.38663325
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37899758
53PU_27001747_Chip-Seq_BMDM_Mouse1.37528569
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37232159
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.35949106
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35510644
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35321809
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32005952
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.27047219
60BCL6_27268052_Chip-Seq_Bcells_Human1.25202839
61MAF_26560356_Chip-Seq_TH2_Human1.24703591
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22120832
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21909001
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21536119
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21384132
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19912063
67CLOCK_20551151_ChIP-Seq_293T_Human1.16732616
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15210643
69LXR_22158963_ChIP-Seq_LIVER_Mouse1.14922518
70BCOR_27268052_Chip-Seq_Bcells_Human1.14765812
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13412025
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12761246
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11233275
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10678763
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10649671
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.10572123
77GATA3_26560356_Chip-Seq_TH2_Human1.10021162
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09903707
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09545968
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09466375
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08749831
82VDR_24787735_ChIP-Seq_THP-1_Human1.08069654
83KDM2B_26808549_Chip-Seq_DND41_Human1.06800362
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06411384
85STAT1_20625510_ChIP-Seq_HELA_Human1.05895093
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05843888
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05355596
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03873443
89LXR_22292898_ChIP-Seq_THP-1_Human1.02886955
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00990460
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99218930
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.98767696
93CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97485136
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97370028
95P300_27268052_Chip-Seq_Bcells_Human0.97173248
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96101605
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95952188
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95864764
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93685315
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92447938
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91834319
102* GATA1_19941827_ChIP-Seq_MEL_Mouse0.91449295
103* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90747247
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90631562
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90358775
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89849754
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89613981
108P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87488276
109E2F1_20622854_ChIP-Seq_HELA_Human0.86250648
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86113400
111* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86071749
112TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85801267
113* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85077566
114GATA1_19941826_ChIP-Seq_K562_Human0.84709576
115RACK7_27058665_Chip-Seq_MCF-7_Human0.82321572
116NCOR1_26117541_ChIP-Seq_K562_Human0.82131308
117GATA2_19941826_ChIP-Seq_K562_Human0.82023692
118ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81956737

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.04197859
2MP0000685_abnormal_immune_system3.22981671
3MP0009785_altered_susceptibility_to3.15058839
4MP0003436_decreased_susceptibility_to3.04926355
5MP0005387_immune_system_phenotype2.96674160
6MP0001790_abnormal_immune_system2.96674160
7MP0003724_increased_susceptibility_to2.78780715
8MP0005671_abnormal_response_to2.74926211
9MP0005000_abnormal_immune_tolerance2.66385482
10MP0002148_abnormal_hypersensitivity_rea2.62318738
11MP0005025_abnormal_response_to2.60980803
12MP0003303_peritoneal_inflammation2.53350209
13MP0006082_CNS_inflammation2.50380094
14MP0001800_abnormal_humoral_immune2.48741635
15MP0002419_abnormal_innate_immunity2.43545375
16* MP0002452_abnormal_antigen_presenting2.35784357
17MP0002166_altered_tumor_susceptibility2.34912641
18MP0002723_abnormal_immune_serum2.27130784
19MP0003300_gastrointestinal_ulcer2.25405640
20MP0004510_myositis2.22710120
21MP0005058_abnormal_lysosome_morphology2.17216052
22MP0003195_calcinosis2.16064950
23* MP0001819_abnormal_immune_cell2.11794476
24* MP0002420_abnormal_adaptive_immunity2.10339569
25MP0004947_skin_inflammation2.08334994
26MP0002006_tumorigenesis1.94643079
27MP0003763_abnormal_thymus_physiology1.90102686
28MP0003191_abnormal_cellular_cholesterol1.87151828
29MP0002138_abnormal_hepatobiliary_system1.85748330
30MP0001533_abnormal_skeleton_physiology1.83490266
31MP0005464_abnormal_platelet_physiology1.83163551
32MP0010155_abnormal_intestine_physiology1.83150546
33MP0002405_respiratory_system_inflammati1.80741785
34MP0001853_heart_inflammation1.78918894
35MP0001845_abnormal_inflammatory_respons1.76492351
36MP0009840_abnormal_foam_cell1.73781249
37MP0002254_reproductive_system_inflammat1.71058944
38MP0005310_abnormal_salivary_gland1.66965014
39* MP0000716_abnormal_immune_system1.64297792
40* MP0002398_abnormal_bone_marrow1.59551606
41MP0003806_abnormal_nucleotide_metabolis1.58207618
42MP0008469_abnormal_protein_level1.54792121
43MP0001873_stomach_inflammation1.54128426
44MP0009333_abnormal_splenocyte_physiolog1.52597655
45MP0005360_urolithiasis1.46873555
46MP0003448_altered_tumor_morphology1.44172649
47MP0003172_abnormal_lysosome_physiology1.37643077
48MP0000689_abnormal_spleen_morphology1.36198491
49MP0009764_decreased_sensitivity_to1.35096173
50MP0009278_abnormal_bone_marrow1.34073805
51MP0002933_joint_inflammation1.33521085
52* MP0002429_abnormal_blood_cell1.33273633
53MP0000858_altered_metastatic_potential1.30781366
54MP0000343_altered_response_to1.30620583
55MP0002722_abnormal_immune_system1.29485381
56MP0003252_abnormal_bile_duct1.24645083
57MP0005397_hematopoietic_system_phenotyp1.24503186
58MP0001545_abnormal_hematopoietic_system1.24503186
59MP0002139_abnormal_hepatobiliary_system1.24047794
60MP0008438_abnormal_cutaneous_collagen1.19957748
61MP0003866_abnormal_defecation1.18224228
62MP0002998_abnormal_bone_remodeling1.17249152
63MP0003566_abnormal_cell_adhesion1.14874085
64MP0003183_abnormal_peptide_metabolism1.10942346
65MP0002877_abnormal_melanocyte_morpholog1.10706539
66MP0004782_abnormal_surfactant_physiolog1.07843374
67MP0003075_altered_response_to1.03277926
68MP0003045_fibrosis1.03152096
69MP0003705_abnormal_hypodermis_morpholog0.99842416
70MP0008875_abnormal_xenobiotic_pharmacok0.99498756
71MP0001851_eye_inflammation0.98634889
72MP0000465_gastrointestinal_hemorrhage0.97969910
73MP0010352_gastrointestinal_tract_polyps0.97661881
74MP0001986_abnormal_taste_sensitivity0.96490163
75MP0005023_abnormal_wound_healing0.95735386
76MP0006054_spinal_hemorrhage0.94817435
77MP0003453_abnormal_keratinocyte_physiol0.94262976
78MP0000604_amyloidosis0.93729503
79MP0010234_abnormal_vibrissa_follicle0.93675895
80MP0004381_abnormal_hair_follicle0.93283069
81MP0009763_increased_sensitivity_to0.92433263
82MP0004808_abnormal_hematopoietic_stem0.91253467
83MP0002396_abnormal_hematopoietic_system0.90855534
84MP0002277_abnormal_respiratory_mucosa0.90116708
85MP0005076_abnormal_cell_differentiation0.89501532
86MP0000703_abnormal_thymus_morphology0.88014797
87MP0005390_skeleton_phenotype0.87861331
88MP0000609_abnormal_liver_physiology0.87740666
89MP0000249_abnormal_blood_vessel0.85967387
90MP0002136_abnormal_kidney_physiology0.84257889
91MP0005075_abnormal_melanosome_morpholog0.84210042
92MP0003656_abnormal_erythrocyte_physiolo0.84137516
93MP0010307_abnormal_tumor_latency0.83411376
94MP0009643_abnormal_urine_homeostasis0.82325743
95MP0005365_abnormal_bile_salt0.80875270
96MP0001958_emphysema0.79985927
97MP0001879_abnormal_lymphatic_vessel0.78917404
98MP0003091_abnormal_cell_migration0.77906236
99MP0005166_decreased_susceptibility_to0.77420145
100MP0010329_abnormal_lipoprotein_level0.77086534
101MP0003186_abnormal_redox_activity0.75244838
102MP0001348_abnormal_lacrimal_gland0.75165678
103MP0002693_abnormal_pancreas_physiology0.74627469
104MP0002876_abnormal_thyroid_physiology0.74411008
105MP0004147_increased_porphyrin_level0.74321034
106MP0003795_abnormal_bone_structure0.71363129
107MP0005584_abnormal_enzyme/coenzyme_acti0.70817781
108MP0000490_abnormal_crypts_of0.68987237
109MP0005164_abnormal_response_to0.67913625
110MP0005165_increased_susceptibility_to0.67256936
111MP0000613_abnormal_salivary_gland0.66568936
112MP0001881_abnormal_mammary_gland0.66325183
113MP0003828_pulmonary_edema0.65805006
114MP0002163_abnormal_gland_morphology0.65096078
115MP0005167_abnormal_blood-brain_barrier0.64893439
116MP0002132_abnormal_respiratory_system0.64114355
117MP0001765_abnormal_ion_homeostasis0.63946263
118MP0005319_abnormal_enzyme/_coenzyme0.61516603
119MP0005275_abnormal_skin_tensile0.60196847
120MP0001663_abnormal_digestive_system0.58783997
121MP0003279_aneurysm0.58426099

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.37625019
2Recurrent abscess formation (HP:0002722)4.85672764
3Elevated erythrocyte sedimentation rate (HP:0003565)4.66585654
4Hypothermia (HP:0002045)4.60547091
5Recurrent bacterial skin infections (HP:0005406)4.37841520
6Myositis (HP:0100614)4.08483830
7Autoimmune thrombocytopenia (HP:0001973)3.95652033
8Recurrent gram-negative bacterial infections (HP:0005420)3.93040271
9Recurrent fungal infections (HP:0002841)3.72803886
10Vacuolated lymphocytes (HP:0001922)3.71133056
11Abnormality of macrophages (HP:0004311)3.69339811
12Interstitial pulmonary disease (HP:0006530)3.64618847
13Recurrent viral infections (HP:0004429)3.54968206
14Orchitis (HP:0100796)3.54791224
15Systemic lupus erythematosus (HP:0002725)3.54637223
16* Abnormality of the nasal mucosa (HP:0000433)3.29013083
17Mediastinal lymphadenopathy (HP:0100721)3.22413827
18Recurrent skin infections (HP:0001581)3.21682276
19* Nasal polyposis (HP:0100582)3.20599457
20* Chronic otitis media (HP:0000389)3.19342419
21Increased cerebral lipofuscin (HP:0011813)3.18836203
22Vasculitis (HP:0002633)3.14255270
23Dysostosis multiplex (HP:0000943)3.08745999
24Pustule (HP:0200039)3.07527004
25Optic neuritis (HP:0100653)3.00924966
26Retrobulbar optic neuritis (HP:0100654)3.00924966
27Chronic mucocutaneous candidiasis (HP:0002728)3.00068432
28Recurrent cutaneous fungal infections (HP:0011370)3.00068432
29Premature loss of primary teeth (HP:0006323)2.99835540
30Spontaneous hematomas (HP:0007420)2.99365914
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.99182131
32* Recurrent bronchitis (HP:0002837)2.97963496
33Hematochezia (HP:0002573)2.88721026
34Urinary glycosaminoglycan excretion (HP:0003541)2.86388564
35Mucopolysacchariduria (HP:0008155)2.86388564
36Gingivitis (HP:0000230)2.85192957
37Colitis (HP:0002583)2.82966827
38Increased neuronal autofluorescent lipopigment (HP:0002074)2.81420395
39Cellulitis (HP:0100658)2.77947337
40Encephalitis (HP:0002383)2.75368019
41Inflammation of the large intestine (HP:0002037)2.74470769
42Increased IgE level (HP:0003212)2.73108646
43Hypergammaglobulinemia (HP:0010702)2.69956388
44Abnormality of T cell number (HP:0011839)2.68856470
45Abnormal rod and cone electroretinograms (HP:0008323)2.66024287
46Gastrointestinal inflammation (HP:0004386)2.65770029
47Periodontitis (HP:0000704)2.63411628
48Stomatitis (HP:0010280)2.61664453
49Abnormality of mucopolysaccharide metabolism (HP:0011020)2.61373909
50Abnormality of polysaccharide metabolism (HP:0011012)2.61373909
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.61373909
52Abnormality of T cell physiology (HP:0011840)2.58381048
53Meningitis (HP:0001287)2.57103348
54Myocardial infarction (HP:0001658)2.57021024
55Increased IgM level (HP:0003496)2.56960304
56Pulmonary infiltrates (HP:0002113)2.56439170
57Abnormality of T cells (HP:0002843)2.55386204
58Loss of speech (HP:0002371)2.54110001
59Arterial thrombosis (HP:0004420)2.53159245
60T lymphocytopenia (HP:0005403)2.48987639
61Thick nail (HP:0001805)2.48202324
62Gastrointestinal infarctions (HP:0005244)2.47562558
63IgM deficiency (HP:0002850)2.46466627
64Thrombocytosis (HP:0001894)2.46442742
65Autoimmune hemolytic anemia (HP:0001890)2.45220119
66Basal ganglia calcification (HP:0002135)2.43695372
67Chronic obstructive pulmonary disease (HP:0006510)2.43249835
68Obstructive lung disease (HP:0006536)2.43249835
69Hemoptysis (HP:0002105)2.41046539
70Alveolar cell carcinoma (HP:0006519)2.40117162
71Global brain atrophy (HP:0002283)2.34332376
72Gingival bleeding (HP:0000225)2.30406015
73Agammaglobulinemia (HP:0004432)2.29513720
74Abnormality of glycolipid metabolism (HP:0010969)2.28214166
75Abnormality of liposaccharide metabolism (HP:0010968)2.28214166
76Abnormality of glycosphingolipid metabolism (HP:0004343)2.28214166
77Leukocytosis (HP:0001974)2.27239243
78Osteomyelitis (HP:0002754)2.25798429
79Absent rod-and cone-mediated responses on ERG (HP:0007688)2.24446270
80Petechiae (HP:0000967)2.24296947
81Enlarged epiphyses (HP:0010580)2.24146747
82Urticaria (HP:0001025)2.23339377
83Glomerulonephritis (HP:0000099)2.19851719
84IgG deficiency (HP:0004315)2.19752384
85Tetraparesis (HP:0002273)2.17580684
86Increased serum ferritin (HP:0003281)2.16474862
87Neoplasm of the tracheobronchial system (HP:0100552)2.15352825
88Joint swelling (HP:0001386)2.15214079
89Eosinophilia (HP:0001880)2.13962736
90Keratoconjunctivitis sicca (HP:0001097)2.13281868
91Abnormality of cells of the lymphoid lineage (HP:0012140)2.11514537
92Prolonged bleeding time (HP:0003010)2.11385770
93Osteolytic defects of the hand bones (HP:0009699)2.10404377
94Osteolytic defects of the phalanges of the hand (HP:0009771)2.10404377
95Lymphopenia (HP:0001888)2.10217803
96Vascular calcification (HP:0004934)2.10213283
97Keratoconjunctivitis (HP:0001096)2.09964071
98Abnormality of eosinophils (HP:0001879)2.08789253
99Nephritis (HP:0000123)2.07767601
100* Emphysema (HP:0002097)2.04829734
101Chronic diarrhea (HP:0002028)2.03995259
102Gastrointestinal stroma tumor (HP:0100723)2.02016539
103Epistaxis (HP:0000421)2.01526848
104Skin rash (HP:0000988)2.01441312
105Anorexia (HP:0002039)2.00935884
106Cheilitis (HP:0100825)2.00694905
107Panhypogammaglobulinemia (HP:0003139)2.00569836
108Increased CSF protein (HP:0002922)2.00017414
109Esophageal varix (HP:0002040)1.99869220
110* Skin ulcer (HP:0200042)1.99276276
111Vertebral compression fractures (HP:0002953)1.99094586
112Granulocytopenia (HP:0001913)1.95685210
113Acne (HP:0001061)1.95615717
114Abnormality of iron homeostasis (HP:0011031)1.95225301
115Peritonitis (HP:0002586)1.94393880
116Hypoproteinemia (HP:0003075)1.94151706
117Pulmonary embolism (HP:0002204)1.93958850
118Arthralgia (HP:0002829)1.93585986
119Polycythemia (HP:0001901)1.93483521
120Abnormality of the pleura (HP:0002103)1.93292045
121Purpura (HP:0000979)1.92335392
122IgA deficiency (HP:0002720)1.90864918
123Recurrent lower respiratory tract infections (HP:0002783)1.84767936
124Chest pain (HP:0100749)1.84733983
125Complement deficiency (HP:0004431)1.83584844

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK23.52392550
2MAP4K13.48238727
3TLK13.46434621
4MAP3K143.38985204
5TBK13.29287780
6ERN13.23283363
7JAK33.20007450
8IKBKE2.88913430
9ARAF2.65666457
10BMPR22.63376340
11FGFR42.58939507
12BLK2.49939218
13JAK12.36828593
14KIT2.29480022
15IRAK42.16435209
16ZAP702.06529496
17TRIB31.95000374
18TGFBR21.94575123
19IRAK31.94513021
20TXK1.94401392
21IKBKB1.92867445
22MAP3K91.89140390
23EPHB11.88982326
24FGFR31.64135312
25STK101.59299931
26CSK1.54732944
27EPHA31.47263813
28NME21.45259657
29TAOK31.44617002
30KDR1.44221407
31CHUK1.42087517
32MAP3K131.38921684
33BTK1.38445561
34MOS1.37066671
35FLT31.36879269
36LRRK21.29585644
37PIM21.29490391
38RPS6KA41.28628364
39BRAF1.27825711
40SYK1.27315186
41ITK1.24428989
42CSF1R1.23101608
43PKN21.20778402
44PTK61.20431300
45TNK21.20015699
46MAP3K101.18291194
47MAP3K71.18087996
48RIPK41.17163577
49EPHA21.16533906
50LCK1.15308851
51TEC1.14683547
52JAK21.11498951
53NLK1.11230284
54HCK1.11050315
55SIK11.10740194
56NEK91.05840383
57MST41.05709520
58KSR21.04717446
59GRK60.98532779
60MAP2K30.91481041
61MAP3K30.90719143
62PIM10.89535094
63TTN0.86283369
64MARK30.83262072
65LYN0.81586179
66RIPK10.81059130
67IRAK10.72721823
68ILK0.72560608
69MAP3K80.69929030
70EEF2K0.69305449
71MAP2K60.66604314
72TESK20.66305012
73MST1R0.65679790
74TIE10.61780791
75PDK10.61292147
76BMX0.58996661
77RAF10.58791843
78MAP3K120.58430112
79MATK0.57482351
80TGFBR10.57307941
81CAMK1D0.56304461
82HIPK20.55731317
83MAPK150.54332959
84TESK10.52697972
85FRK0.51996658
86TRPM70.51659078
87GRK70.49686896
88FES0.49157402
89LMTK20.48755703
90PDPK10.47635721
91PRKCQ0.47499613
92PRKCH0.46862950
93PRKG20.46761498
94EGFR0.46738952
95SIK30.46502451
96MAP3K10.46292689
97MAPKAPK20.45396837
98ADRBK20.45174194
99ABL10.44369736
100MAP2K20.44223066
101CDC42BPA0.43344464
102PRKCD0.42980572
103MAPK110.42791091
104MAPKAPK30.42699724
105RPS6KA60.42480992
106PAK40.41512587
107STK380.41387304
108TAOK10.40192616
109STK40.39328102
110PRPF4B0.38901569
111PRKAA20.38853152
112ACVR1B0.38062567
113SCYL20.37105969
114PTK2B0.36745069
115KSR10.36673259
116PIK3CG0.36166974
117PRKD20.35783150
118MAP3K20.34925317
119MAP2K10.33085803
120CLK10.32764465
121SIK20.31350303
122CDK60.31296997
123IGF1R0.31015982
124MAP3K110.30485391
125PASK0.29850129
126MYLK0.29730840
127PDGFRA0.29321682
128INSRR0.28732630
129PTK20.28209878
130MUSK0.28104341
131DYRK1B0.28066932
132FER0.27555842
133PDGFRB0.27114368
134FGR0.27007301
135ABL20.26535232
136FYN0.26381185
137RPS6KA50.25837311
138STK240.25787481
139MAP4K20.22004777
140GRK10.21594200

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.00163984
2Staphylococcus aureus infection_Homo sapiens_hsa051502.64699999
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.56466765
4Primary immunodeficiency_Homo sapiens_hsa053402.52690760
5Measles_Homo sapiens_hsa051622.38971894
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.36880661
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.35084703
8Osteoclast differentiation_Homo sapiens_hsa043802.28986206
9Allograft rejection_Homo sapiens_hsa053302.20257746
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.17198347
11Graft-versus-host disease_Homo sapiens_hsa053322.11661962
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.08619881
13* Antigen processing and presentation_Homo sapiens_hsa046122.04521588
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.04078791
15Legionellosis_Homo sapiens_hsa051342.02836466
16Pertussis_Homo sapiens_hsa051332.01179187
17Malaria_Homo sapiens_hsa051441.92082854
18Other glycan degradation_Homo sapiens_hsa005111.87368291
19Toxoplasmosis_Homo sapiens_hsa051451.84819918
20B cell receptor signaling pathway_Homo sapiens_hsa046621.84316575
21Influenza A_Homo sapiens_hsa051641.77117865
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.74965224
23TNF signaling pathway_Homo sapiens_hsa046681.74561218
24Lysosome_Homo sapiens_hsa041421.73474458
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68504596
26Tuberculosis_Homo sapiens_hsa051521.67577045
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.63017946
28Herpes simplex infection_Homo sapiens_hsa051681.60289356
29Hematopoietic cell lineage_Homo sapiens_hsa046401.54150295
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48901723
31Apoptosis_Homo sapiens_hsa042101.41856408
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39708040
33Caffeine metabolism_Homo sapiens_hsa002321.37770294
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35720527
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33758003
36T cell receptor signaling pathway_Homo sapiens_hsa046601.29904149
37Viral myocarditis_Homo sapiens_hsa054161.29069290
38Shigellosis_Homo sapiens_hsa051311.26575228
39Autoimmune thyroid disease_Homo sapiens_hsa053201.24891855
40Chemokine signaling pathway_Homo sapiens_hsa040621.24621119
41Rheumatoid arthritis_Homo sapiens_hsa053231.23204418
42Linoleic acid metabolism_Homo sapiens_hsa005911.21329023
43Hepatitis C_Homo sapiens_hsa051601.20307034
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.19396112
45Salmonella infection_Homo sapiens_hsa051321.17675378
46Hepatitis B_Homo sapiens_hsa051611.16938835
47Asthma_Homo sapiens_hsa053101.12282789
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12140623
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11905629
50Acute myeloid leukemia_Homo sapiens_hsa052211.11721650
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11588803
52Type I diabetes mellitus_Homo sapiens_hsa049401.09302806
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08478795
54African trypanosomiasis_Homo sapiens_hsa051430.96308674
55Complement and coagulation cascades_Homo sapiens_hsa046100.95138123
56Phagosome_Homo sapiens_hsa041450.91045362
57Arachidonic acid metabolism_Homo sapiens_hsa005900.90257636
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.87669180
59Prolactin signaling pathway_Homo sapiens_hsa049170.86173602
60Chronic myeloid leukemia_Homo sapiens_hsa052200.84730567
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83739054
62Amoebiasis_Homo sapiens_hsa051460.82870284
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82513377
64Pancreatic cancer_Homo sapiens_hsa052120.82315954
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79821141
66Small cell lung cancer_Homo sapiens_hsa052220.76062274
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73717939
68ABC transporters_Homo sapiens_hsa020100.73237129
69Insulin resistance_Homo sapiens_hsa049310.68218809
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67851551
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67393511
72Platelet activation_Homo sapiens_hsa046110.67351885
73Ether lipid metabolism_Homo sapiens_hsa005650.65260468
74Sphingolipid metabolism_Homo sapiens_hsa006000.64835292
75Collecting duct acid secretion_Homo sapiens_hsa049660.60179264
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.57399638
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.55381751
78Viral carcinogenesis_Homo sapiens_hsa052030.52177811
79Systemic lupus erythematosus_Homo sapiens_hsa053220.51303414
80HTLV-I infection_Homo sapiens_hsa051660.50171244
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49423124
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.49075310
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48175762
84Mineral absorption_Homo sapiens_hsa049780.47357458
85Epstein-Barr virus infection_Homo sapiens_hsa051690.46950151
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46004343
87Prion diseases_Homo sapiens_hsa050200.44890787
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43096854
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42324509
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42162913
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42065124
92Notch signaling pathway_Homo sapiens_hsa043300.41838864
93Renin-angiotensin system_Homo sapiens_hsa046140.40922698
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.40894306
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.40360803
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39678027
97Inositol phosphate metabolism_Homo sapiens_hsa005620.38716036
98HIF-1 signaling pathway_Homo sapiens_hsa040660.37390918
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37358322
100PPAR signaling pathway_Homo sapiens_hsa033200.36509584
101VEGF signaling pathway_Homo sapiens_hsa043700.35953796
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.35245289
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34567083
104Non-small cell lung cancer_Homo sapiens_hsa052230.33980926
105Proteoglycans in cancer_Homo sapiens_hsa052050.33883243
106Focal adhesion_Homo sapiens_hsa045100.31505899
107Fatty acid metabolism_Homo sapiens_hsa012120.31283108
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30148113
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27659147
110Fat digestion and absorption_Homo sapiens_hsa049750.26015889
111Endocytosis_Homo sapiens_hsa041440.25198921
112Adherens junction_Homo sapiens_hsa045200.24192577
113Pentose phosphate pathway_Homo sapiens_hsa000300.23443202
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23333114
115Dorso-ventral axis formation_Homo sapiens_hsa043200.23324106
116Bladder cancer_Homo sapiens_hsa052190.23270839
117Tryptophan metabolism_Homo sapiens_hsa003800.22739441
118Histidine metabolism_Homo sapiens_hsa003400.22529374
119FoxO signaling pathway_Homo sapiens_hsa040680.22322358
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22209156
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21884969
122Starch and sucrose metabolism_Homo sapiens_hsa005000.21437580
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20935663
124Galactose metabolism_Homo sapiens_hsa000520.20627143
125Type II diabetes mellitus_Homo sapiens_hsa049300.20383229
126Fatty acid degradation_Homo sapiens_hsa000710.20378301
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.18843578
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18537501

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