TAPBPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.45649119
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.19234577
3negative regulation of cell killing (GO:0031342)5.19234577
4DNA deamination (GO:0045006)4.60487391
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.25302679
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.25302679
7antigen processing and presentation of endogenous antigen (GO:0019883)4.21240088
8regulation of gamma-delta T cell activation (GO:0046643)4.14923468
9regulation of gamma-delta T cell differentiation (GO:0045586)3.98229075
10ribosomal small subunit biogenesis (GO:0042274)3.95480995
11detection of bacterium (GO:0016045)3.85987558
12detection of other organism (GO:0098543)3.85322985
13positive regulation by symbiont of host defense response (GO:0052509)3.65803111
14modulation by symbiont of host defense response (GO:0052031)3.65803111
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.65803111
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.65803111
17positive regulation by organism of defense response of other organism involved in symbiotic interact3.65803111
18modulation by symbiont of host immune response (GO:0052553)3.65803111
19macrophage activation involved in immune response (GO:0002281)3.57964773
20regulation of nuclear cell cycle DNA replication (GO:0033262)3.52359360
21positive thymic T cell selection (GO:0045059)3.48578588
22interferon-gamma-mediated signaling pathway (GO:0060333)3.42019561
23negative regulation of interleukin-12 production (GO:0032695)3.39719527
24interferon-gamma production (GO:0032609)3.37152243
25proteasome assembly (GO:0043248)3.35420877
26regulation of T cell mediated cytotoxicity (GO:0001914)3.35106880
27rRNA modification (GO:0000154)3.34602033
28B cell mediated immunity (GO:0019724)3.31175240
29positive regulation of T cell mediated cytotoxicity (GO:0001916)3.30803308
30leukocyte aggregation (GO:0070486)3.30157035
31positive regulation of B cell differentiation (GO:0045579)3.28286225
32granulocyte activation (GO:0036230)3.27328035
33regulation of alpha-beta T cell proliferation (GO:0046640)3.23996184
34deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.23693683
35negative regulation of lymphocyte mediated immunity (GO:0002707)3.23462826
36regulation of regulatory T cell differentiation (GO:0045589)3.21350333
37detection of external biotic stimulus (GO:0098581)3.19703133
38regulation of T cell tolerance induction (GO:0002664)3.19541285
39negative regulation of leukocyte mediated immunity (GO:0002704)3.16852078
40B cell receptor signaling pathway (GO:0050853)3.15165132
41response to interferon-beta (GO:0035456)3.13695470
42mitochondrial DNA replication (GO:0006264)3.12318938
43tolerance induction (GO:0002507)3.09922619
44cellular response to type I interferon (GO:0071357)3.09502046
45type I interferon signaling pathway (GO:0060337)3.09502046
46cellular response to interleukin-15 (GO:0071350)3.09135709
47negative regulation of T cell mediated immunity (GO:0002710)3.08116974
48regulation of interferon-beta biosynthetic process (GO:0045357)3.07447415
49ribosomal small subunit assembly (GO:0000028)3.05827417
50response to type I interferon (GO:0034340)3.05799555
51negative regulation of innate immune response (GO:0045824)3.01093817
52telomere maintenance via semi-conservative replication (GO:0032201)2.99259560
53response to protozoan (GO:0001562)2.97595765
54myeloid cell activation involved in immune response (GO:0002275)2.97285252
55regulation of isotype switching to IgG isotypes (GO:0048302)2.97203509
56regulation of tolerance induction (GO:0002643)2.97071262
57NIK/NF-kappaB signaling (GO:0038061)2.96939891
58deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.96293929
59natural killer cell activation involved in immune response (GO:0002323)2.96089130
60response to peptidoglycan (GO:0032494)2.95069772
61regulation of B cell differentiation (GO:0045577)2.94945735
62dendritic cell chemotaxis (GO:0002407)2.94288379
63sequestering of actin monomers (GO:0042989)2.93602148
64termination of RNA polymerase III transcription (GO:0006386)2.93467586
65transcription elongation from RNA polymerase III promoter (GO:0006385)2.93467586
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.92964281
67ribosomal large subunit biogenesis (GO:0042273)2.92539958
68germinal center formation (GO:0002467)2.91654141
69purine deoxyribonucleotide catabolic process (GO:0009155)2.90211844
70positive regulation of antigen processing and presentation (GO:0002579)2.90099051
71ribonucleoprotein complex biogenesis (GO:0022613)2.90033648
72T cell selection (GO:0045058)2.90010303
73cellular extravasation (GO:0045123)2.89927060
74antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.89012824
75thymic T cell selection (GO:0045061)2.88275955
76regulation of natural killer cell mediated immunity (GO:0002715)2.87893532
77regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.87893532
78cellular response to interferon-beta (GO:0035458)2.87837652
79regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.86712827
80positive T cell selection (GO:0043368)2.85178934
81regulation of leukocyte mediated cytotoxicity (GO:0001910)2.84489746
82GDP-mannose metabolic process (GO:0019673)2.83963844
83positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83777775
84cytidine deamination (GO:0009972)2.83685200
85cytidine metabolic process (GO:0046087)2.83685200
86cytidine catabolic process (GO:0006216)2.83685200
87DNA damage response, detection of DNA damage (GO:0042769)2.83632299
88lymphocyte chemotaxis (GO:0048247)2.81834021
89rRNA methylation (GO:0031167)2.80350772
90detection of biotic stimulus (GO:0009595)2.80239339
91SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.80056237
92exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79417828
93DNA replication checkpoint (GO:0000076)2.79139343
94RNA destabilization (GO:0050779)2.77902891
95lipopolysaccharide-mediated signaling pathway (GO:0031663)2.77606028
96cotranslational protein targeting to membrane (GO:0006613)2.77171233
97viral transcription (GO:0019083)2.76610705
98nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75775447
99pseudouridine synthesis (GO:0001522)2.75718861
100myeloid dendritic cell activation (GO:0001773)2.75447526
101myeloid dendritic cell differentiation (GO:0043011)2.75324671
102Arp2/3 complex-mediated actin nucleation (GO:0034314)2.74418260
103positive regulation of defense response to virus by host (GO:0002230)2.74330849
104protein targeting to ER (GO:0045047)2.73947640
105antigen processing and presentation via MHC class Ib (GO:0002475)2.73395889
106positive regulation of alpha-beta T cell proliferation (GO:0046641)2.73295686
107positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.73142367
108positive regulation of tolerance induction (GO:0002645)2.72404095
109response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.70608094
110response to host immune response (GO:0052572)2.70608094
111response to muramyl dipeptide (GO:0032495)2.70460620
112negative regulation of cytokine production involved in immune response (GO:0002719)2.70314138
113regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.70212123
114regulation of cell killing (GO:0031341)2.67862745
115response to interleukin-15 (GO:0070672)2.67165565
116negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.67148363
117regulation of mast cell degranulation (GO:0043304)2.66942332
118* regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.66740729
119detection of molecule of bacterial origin (GO:0032490)2.65615368
120cellular response to interferon-gamma (GO:0071346)2.65155485
121deoxyribonucleotide biosynthetic process (GO:0009263)2.64159961
122protein localization to endoplasmic reticulum (GO:0070972)2.63018729
123translational termination (GO:0006415)2.62844322
124negative regulation of type 2 immune response (GO:0002829)2.62070633
125antigen receptor-mediated signaling pathway (GO:0050851)2.62057334
126T cell migration (GO:0072678)2.61509727
127telomere maintenance via recombination (GO:0000722)2.61078367
128regulation of myeloid leukocyte mediated immunity (GO:0002886)2.60573392
129positive regulation of gamma-delta T cell activation (GO:0046645)2.58731985
130neutrophil activation involved in immune response (GO:0002283)2.58455477
131tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55655281
132RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.55655281
133immunoglobulin mediated immune response (GO:0016064)2.55581789
134signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.55158429
135signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.55158429
136signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.55158429
137deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.54853821
138DNA-dependent DNA replication (GO:0006261)2.54414882
139establishment of protein localization to endoplasmic reticulum (GO:0072599)2.54248630
140maturation of SSU-rRNA (GO:0030490)2.53183616
141muscle organ morphogenesis (GO:0048644)2.52759373
142signal peptide processing (GO:0006465)2.52676332
143transcription from RNA polymerase I promoter (GO:0006360)2.51552480
144negative T cell selection (GO:0043383)2.51200148
145ribosome biogenesis (GO:0042254)2.50815467
146positive regulation of isotype switching (GO:0045830)2.50401241
147DNA strand elongation involved in DNA replication (GO:0006271)2.49666275
148* regulation of antigen processing and presentation (GO:0002577)2.49654733
149antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.48408849
150DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.48163904
151ribosome assembly (GO:0042255)2.47774892
152RNA methylation (GO:0001510)2.47017022
153neutrophil activation (GO:0042119)2.46184527
154DNA strand elongation (GO:0022616)2.44683996
155translation (GO:0006412)2.44303285
156negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.44102391
157regulation of B cell receptor signaling pathway (GO:0050855)2.43675655
158signal transduction involved in DNA damage checkpoint (GO:0072422)2.43317159
159signal transduction involved in DNA integrity checkpoint (GO:0072401)2.43317159
160signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.42129425
161intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.42129425
162cellular component biogenesis (GO:0044085)2.42072504
163negative thymic T cell selection (GO:0045060)2.41756915
164regulation of RIG-I signaling pathway (GO:0039535)2.41706484
165rRNA processing (GO:0006364)2.40540696
166signal transduction involved in cell cycle checkpoint (GO:0072395)2.40538360
167regulation of dendritic cell antigen processing and presentation (GO:0002604)2.39891307
168positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.39589804
169maturation of 5.8S rRNA (GO:0000460)2.39129698
170cellular response to exogenous dsRNA (GO:0071360)2.39095753
171respiratory burst (GO:0045730)2.39045226
172defense response to protozoan (GO:0042832)2.38771815
173mRNA modification (GO:0016556)2.36842532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.00361080
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.63592683
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.62557732
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.52827482
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.47184093
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.41967691
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.37202889
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.12714992
9* IRF8_21731497_ChIP-ChIP_J774_Mouse3.12387249
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.95031624
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92412240
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.67796028
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.50165649
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.50138669
15RUNX_20019798_ChIP-Seq_JUKART_Human2.49802676
16VDR_23849224_ChIP-Seq_CD4+_Human2.39920314
17* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.33090660
18* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.32969146
19* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.28473114
20SCL_19346495_ChIP-Seq_HPC-7_Human2.20256057
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18133533
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.18001211
23VDR_24763502_ChIP-Seq_THP-1_Human2.16391349
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15335126
25* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.15328922
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14505969
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.11066201
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.10766480
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09025765
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08403603
31MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07726546
32CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06286400
33FOXP3_21729870_ChIP-Seq_TREG_Human2.01165168
34UTX_26944678_Chip-Seq_JUKART_Human2.00795065
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97191633
36SPI1_23127762_ChIP-Seq_K562_Human1.93921727
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91504516
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88313539
39ELK1_19687146_ChIP-ChIP_HELA_Human1.83252070
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.83146044
41SPI1_23547873_ChIP-Seq_NB4_Human1.81204320
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79984283
43MYC_22102868_ChIP-Seq_BL_Human1.78089469
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76018452
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75805643
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75805643
47KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75805643
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74929148
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73926068
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69855023
51GATA3_27048872_Chip-Seq_THYMUS_Human1.67847916
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67300778
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64940341
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.62989059
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62320889
56DCP1A_22483619_ChIP-Seq_HELA_Human1.61073789
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.59451482
58XRN2_22483619_ChIP-Seq_HELA_Human1.58424879
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56991643
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55317712
61* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54554283
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53285771
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53024381
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52613997
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.50004445
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49469108
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46019187
68* IRF8_27001747_Chip-Seq_BMDM_Mouse1.44884056
69LXR_22292898_ChIP-Seq_THP-1_Human1.44380860
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43900716
71TCF7_22412390_ChIP-Seq_EML_Mouse1.41739505
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41672536
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41148482
74GATA3_26560356_Chip-Seq_TH2_Human1.40563256
75BCL6_27268052_Chip-Seq_Bcells_Human1.39950757
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39692273
77VDR_24787735_ChIP-Seq_THP-1_Human1.39277680
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37922024
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.37790866
80MYB_26560356_Chip-Seq_TH1_Human1.36949767
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35917892
82* MYB_26560356_Chip-Seq_TH2_Human1.34738397
83TTF2_22483619_ChIP-Seq_HELA_Human1.33742353
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32699952
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.31240567
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30623022
87GABP_19822575_ChIP-Seq_HepG2_Human1.29942211
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29844155
89STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28952896
90BCOR_27268052_Chip-Seq_Bcells_Human1.28200526
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27514306
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.27506909
93GATA1_19941826_ChIP-Seq_K562_Human1.27497044
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26892090
95* ELK3_25401928_ChIP-Seq_HUVEC_Human1.26041917
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22745044
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19095839
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18502330
99GATA1_22025678_ChIP-Seq_K562_Human1.18201634
100ELK1_22589737_ChIP-Seq_MCF10A_Human1.18080874
101SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17533988
102* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17360096
103KDM2B_26808549_Chip-Seq_DND41_Human1.16943509
104RXR_22158963_ChIP-Seq_LIVER_Mouse1.16419780
105NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16260777
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14543597
107TP63_19390658_ChIP-ChIP_HaCaT_Human1.13658862
108SMAD_19615063_ChIP-ChIP_OVARY_Human1.13020965
109PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12704520
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11974106
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11684966
112PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11527289
113MAF_26560356_Chip-Seq_TH2_Human1.10218857
114LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10028513
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09840201
116NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08473268
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07943911
118CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07833423
119IRF1_19129219_ChIP-ChIP_H3396_Human1.07660815
120CIITA_25753668_ChIP-Seq_RAJI_Human1.06961452
121STAT1_20625510_ChIP-Seq_HELA_Human1.06268533
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04819974
123ELF1_20517297_ChIP-Seq_JURKAT_Human1.04779839
124SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04454590
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04243010
126MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03959500
127RUNX1_22412390_ChIP-Seq_EML_Mouse1.03539224
128MAF_26560356_Chip-Seq_TH1_Human1.03488153
129EGR1_19374776_ChIP-ChIP_THP-1_Human1.02454532
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00995874
131GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00662521
132KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99968009
133GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99599456
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98747425
135MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97577994
136POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96811908
137FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96376477
138RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96235923
139P300_27268052_Chip-Seq_Bcells_Human0.96068907
140* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95551629
141MYC_18940864_ChIP-ChIP_HL60_Human0.95080505
142RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94919221
143GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94660632
144FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93632900
145STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93106484
146PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93088470
147VDR_21846776_ChIP-Seq_THP-1_Human0.92877004
148PU_27001747_Chip-Seq_BMDM_Mouse0.92837979
149PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92378883
150* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92301390
151GATA2_19941826_ChIP-Seq_K562_Human0.91898588
152NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91091801
153CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90948582
154PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90944895
155SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90261812
156VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89873289
157ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.86772352
158SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86306816
159CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86063863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.13897466
2MP0005671_abnormal_response_to3.15559911
3MP0009785_altered_susceptibility_to2.93682357
4MP0001790_abnormal_immune_system2.80206283
5MP0005387_immune_system_phenotype2.80206283
6MP0005000_abnormal_immune_tolerance2.67797504
7MP0008057_abnormal_DNA_replication2.67459406
8MP0003763_abnormal_thymus_physiology2.66660664
9MP0002148_abnormal_hypersensitivity_rea2.66464857
10MP0001800_abnormal_humoral_immune2.65340655
11MP0005025_abnormal_response_to2.54141199
12MP0006082_CNS_inflammation2.52753447
13MP0000685_abnormal_immune_system2.52233054
14MP0001853_heart_inflammation2.47848128
15MP0002723_abnormal_immune_serum2.38452283
16MP0003436_decreased_susceptibility_to2.32791127
17MP0002452_abnormal_antigen_presenting2.29376145
18MP0002420_abnormal_adaptive_immunity2.19911447
19MP0001819_abnormal_immune_cell2.19792073
20MP0003693_abnormal_embryo_hatching2.19719147
21MP0003724_increased_susceptibility_to2.18609959
22MP0005075_abnormal_melanosome_morpholog2.02768388
23MP0002277_abnormal_respiratory_mucosa2.01341031
24MP0002419_abnormal_innate_immunity2.00999617
25MP0005310_abnormal_salivary_gland1.96824120
26MP0003300_gastrointestinal_ulcer1.94755119
27MP0002138_abnormal_hepatobiliary_system1.94291926
28MP0005058_abnormal_lysosome_morphology1.92478145
29MP0009333_abnormal_splenocyte_physiolog1.92346829
30MP0003183_abnormal_peptide_metabolism1.92193275
31MP0004381_abnormal_hair_follicle1.85933345
32MP0008058_abnormal_DNA_repair1.84575768
33MP0000716_abnormal_immune_system1.84405438
34MP0002398_abnormal_bone_marrow1.83166054
35MP0006292_abnormal_olfactory_placode1.82433506
36MP0003191_abnormal_cellular_cholesterol1.80158902
37MP0009379_abnormal_foot_pigmentation1.76832213
38MP0002139_abnormal_hepatobiliary_system1.74025939
39MP0000689_abnormal_spleen_morphology1.72462174
40MP0002405_respiratory_system_inflammati1.67812328
41MP0001873_stomach_inflammation1.66596038
42MP0002722_abnormal_immune_system1.64871836
43MP0000465_gastrointestinal_hemorrhage1.61743475
44MP0010155_abnormal_intestine_physiology1.55552109
45MP0001845_abnormal_inflammatory_respons1.53902461
46MP0002429_abnormal_blood_cell1.53157430
47MP0003172_abnormal_lysosome_physiology1.51829438
48MP0009840_abnormal_foam_cell1.50792020
49MP0004957_abnormal_blastocyst_morpholog1.50411695
50MP0002254_reproductive_system_inflammat1.49086619
51MP0008469_abnormal_protein_level1.47122952
52MP0003186_abnormal_redox_activity1.42558426
53MP0002166_altered_tumor_susceptibility1.41715657
54MP0001986_abnormal_taste_sensitivity1.40895427
55MP0000703_abnormal_thymus_morphology1.37820102
56MP0002132_abnormal_respiratory_system1.36633334
57MP0003075_altered_response_to1.35315993
58MP0004510_myositis1.35246748
59MP0000858_altered_metastatic_potential1.34368183
60MP0009278_abnormal_bone_marrow1.34194845
61MP0002006_tumorigenesis1.32191749
62MP0005451_abnormal_body_composition1.31338192
63MP0001348_abnormal_lacrimal_gland1.31324574
64MP0003077_abnormal_cell_cycle1.30077120
65MP0005174_abnormal_tail_pigmentation1.27722788
66MP0004947_skin_inflammation1.27679988
67MP0009764_decreased_sensitivity_to1.25314996
68MP0005360_urolithiasis1.22763441
69MP0002396_abnormal_hematopoietic_system1.20830258
70MP0000613_abnormal_salivary_gland1.20808241
71MP0002163_abnormal_gland_morphology1.20765608
72MP0005464_abnormal_platelet_physiology1.19258228
73MP0002998_abnormal_bone_remodeling1.17745619
74MP0000604_amyloidosis1.17669957
75MP0008007_abnormal_cellular_replicative1.17152007
76MP0005397_hematopoietic_system_phenotyp1.15994645
77MP0001545_abnormal_hematopoietic_system1.15994645
78MP0003111_abnormal_nucleus_morphology1.13481512
79MP0005409_darkened_coat_color1.12863856
80MP0005379_endocrine/exocrine_gland_phen1.12433736
81MP0003866_abnormal_defecation1.12328380
82MP0003806_abnormal_nucleotide_metabolis1.12000879
83MP0003786_premature_aging1.11768666
84MP0008260_abnormal_autophagy1.11008760
85MP0005166_decreased_susceptibility_to1.10467793
86MP0003448_altered_tumor_morphology1.06905864
87MP0009765_abnormal_xenobiotic_induced1.05968181
88MP0010094_abnormal_chromosome_stability1.05089976
89MP0000490_abnormal_crypts_of1.01807018
90MP0000343_altered_response_to1.01578346
91MP0002876_abnormal_thyroid_physiology1.01462731
92MP0001188_hyperpigmentation0.99358470
93MP0003718_maternal_effect0.98849827
94MP0002933_joint_inflammation0.97543338
95MP0003828_pulmonary_edema0.95113563
96MP0002019_abnormal_tumor_incidence0.93374799
97MP0001663_abnormal_digestive_system0.92562231
98MP0005365_abnormal_bile_salt0.91388619
99MP0003045_fibrosis0.90245849
100MP0005164_abnormal_response_to0.90189710
101MP0000015_abnormal_ear_pigmentation0.89435768
102MP0004883_abnormal_blood_vessel0.88832124
103MP0000313_abnormal_cell_death0.87005162
104MP0006035_abnormal_mitochondrial_morpho0.86821354
105MP0008877_abnormal_DNA_methylation0.86387856
106MP0009763_increased_sensitivity_to0.86287387
107MP0008932_abnormal_embryonic_tissue0.84700620
108MP0001764_abnormal_homeostasis0.83744285
109MP0000249_abnormal_blood_vessel0.82566309
110MP0002693_abnormal_pancreas_physiology0.81969231
111MP0005390_skeleton_phenotype0.81655923
112MP0004782_abnormal_surfactant_physiolog0.80649484
113MP0001533_abnormal_skeleton_physiology0.80282319
114MP0000678_abnormal_parathyroid_gland0.78322439
115MP0008004_abnormal_stomach_pH0.77637839
116MP0003690_abnormal_glial_cell0.75622954
117MP0003195_calcinosis0.75128344
118MP0003656_abnormal_erythrocyte_physiolo0.73483779
119MP0005085_abnormal_gallbladder_physiolo0.72982238
120MP0003941_abnormal_skin_development0.72867965
121MP0000609_abnormal_liver_physiology0.71534064
122MP0005167_abnormal_blood-brain_barrier0.71414330
123MP0005389_reproductive_system_phenotype0.69731419
124MP0003011_delayed_dark_adaptation0.69257297
125MP0002095_abnormal_skin_pigmentation0.69172826
126MP0002332_abnormal_exercise_endurance0.68995685
127MP0005319_abnormal_enzyme/_coenzyme0.68953501
128MP0003252_abnormal_bile_duct0.67994101
129MP0003795_abnormal_bone_structure0.67650461
130MP0009643_abnormal_urine_homeostasis0.66297301
131MP0001919_abnormal_reproductive_system0.65163787
132MP0005165_increased_susceptibility_to0.63390781
133MP0002136_abnormal_kidney_physiology0.63145124
134MP0008874_decreased_physiological_sensi0.62194825
135MP0001851_eye_inflammation0.61834827
136MP0005584_abnormal_enzyme/coenzyme_acti0.61687453
137MP0002160_abnormal_reproductive_system0.61366837
138MP0008873_increased_physiological_sensi0.57980658
139MP0003303_peritoneal_inflammation0.57559536
140MP0008875_abnormal_xenobiotic_pharmacok0.56583210

Predicted human phenotypes

RankGene SetZ-score
1Progressive external ophthalmoplegia (HP:0000590)3.87396943
2Elevated erythrocyte sedimentation rate (HP:0003565)3.81403084
3Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.72851440
4Granulocytopenia (HP:0001913)3.67974081
5IgM deficiency (HP:0002850)3.61832715
6Systemic lupus erythematosus (HP:0002725)3.60251704
7Recurrent gram-negative bacterial infections (HP:0005420)3.46377510
8Abnormality of glycolipid metabolism (HP:0010969)3.37520882
9Abnormality of liposaccharide metabolism (HP:0010968)3.37520882
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.37520882
11Spontaneous hematomas (HP:0007420)3.25085433
12Gastrointestinal infarctions (HP:0005244)3.18385586
13Nasal polyposis (HP:0100582)3.15286761
14Increased IgM level (HP:0003496)3.12752691
15Eczematoid dermatitis (HP:0000976)3.10518627
16Eosinophilia (HP:0001880)3.09209232
17Type I transferrin isoform profile (HP:0003642)3.05018552
18Pustule (HP:0200039)3.04478246
19Recurrent bronchitis (HP:0002837)3.03012750
20IgG deficiency (HP:0004315)3.01335079
21Chronic otitis media (HP:0000389)2.97821898
22Abnormality of T cell physiology (HP:0011840)2.97591660
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.95562364
24Pulmonary infiltrates (HP:0002113)2.94627852
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.93911926
26Recurrent viral infections (HP:0004429)2.92193865
27Recurrent abscess formation (HP:0002722)2.89587271
28Abnormality of macrophages (HP:0004311)2.88669850
29Autoimmune hemolytic anemia (HP:0001890)2.87907747
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.86372056
31Abnormality of T cells (HP:0002843)2.84895880
32Recurrent fungal infections (HP:0002841)2.81596739
33Myositis (HP:0100614)2.79358990
34Chromsome breakage (HP:0040012)2.78122000
35Keratoconjunctivitis sicca (HP:0001097)2.77116451
36Hemoptysis (HP:0002105)2.76988866
37Urticaria (HP:0001025)2.75990192
38Abnormality of T cell number (HP:0011839)2.75080924
39Progressive muscle weakness (HP:0003323)2.75079028
40Recurrent cutaneous fungal infections (HP:0011370)2.74673695
41Chronic mucocutaneous candidiasis (HP:0002728)2.74673695
42Colitis (HP:0002583)2.72679244
43Inflammation of the large intestine (HP:0002037)2.72372852
44Combined immunodeficiency (HP:0005387)2.71846822
45Abnormality of eosinophils (HP:0001879)2.71468418
46Chronic diarrhea (HP:0002028)2.71056936
47Increased cerebral lipofuscin (HP:0011813)2.70198179
48T lymphocytopenia (HP:0005403)2.69194075
49Reduced antithrombin III activity (HP:0001976)2.68554311
50Abnormality of B cell number (HP:0010975)2.67392910
51B lymphocytopenia (HP:0010976)2.67392910
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.67061871
53Autoimmune thrombocytopenia (HP:0001973)2.66710752
54Gastrointestinal inflammation (HP:0004386)2.64768182
55Prolonged bleeding time (HP:0003010)2.64734380
56Severe combined immunodeficiency (HP:0004430)2.63841696
57Dysostosis multiplex (HP:0000943)2.62556794
58Epistaxis (HP:0000421)2.61263046
59Reticulocytopenia (HP:0001896)2.59749772
60Purpura (HP:0000979)2.59296879
61Panhypogammaglobulinemia (HP:0003139)2.58923593
62Abnormality of the nasal mucosa (HP:0000433)2.58918925
63Gingival bleeding (HP:0000225)2.57293797
64Chest pain (HP:0100749)2.56108219
65Recurrent bacterial skin infections (HP:0005406)2.55617649
66Keratoconjunctivitis (HP:0001096)2.52231082
67Breast hypoplasia (HP:0003187)2.51649830
68Pulmonary embolism (HP:0002204)2.50744814
693-Methylglutaconic aciduria (HP:0003535)2.50231472
70Increased neuronal autofluorescent lipopigment (HP:0002074)2.47578251
71Cellulitis (HP:0100658)2.45463253
72Gastrointestinal stroma tumor (HP:0100723)2.42183987
73Arterial thrombosis (HP:0004420)2.40668484
74Encephalitis (HP:0002383)2.39676259
75Anorexia (HP:0002039)2.39436392
76Abnormality of the prostate (HP:0008775)2.39174856
77Recurrent skin infections (HP:0001581)2.38328623
78Increased serum ferritin (HP:0003281)2.37626391
79Meningitis (HP:0001287)2.37600171
80Cheilitis (HP:0100825)2.36636905
81Joint swelling (HP:0001386)2.33591935
82Obstructive lung disease (HP:0006536)2.32127745
83Chronic obstructive pulmonary disease (HP:0006510)2.32127745
84Vasculitis (HP:0002633)2.31633011
85Hypergammaglobulinemia (HP:0010702)2.30040234
86Abnormality of the pleura (HP:0002103)2.29643503
87Increased IgE level (HP:0003212)2.28887804
88Leukocytosis (HP:0001974)2.27545277
89Exertional dyspnea (HP:0002875)2.26112202
90Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25357781
91Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25357781
92Hepatosplenomegaly (HP:0001433)2.23922662
93Recurrent sinusitis (HP:0011108)2.22751555
94Pancytopenia (HP:0001876)2.21995349
95Retrobulbar optic neuritis (HP:0100654)2.19155514
96Optic neuritis (HP:0100653)2.19155514
97Recurrent pneumonia (HP:0006532)2.18428787
98Loss of speech (HP:0002371)2.18206910
99Birth length less than 3rd percentile (HP:0003561)2.17668067
100Orchitis (HP:0100796)2.17233605
101Gangrene (HP:0100758)2.16802312
102Abnormality of iron homeostasis (HP:0011031)2.16764760
103Agammaglobulinemia (HP:0004432)2.16242520
104Renal Fanconi syndrome (HP:0001994)2.15026912
105Prostate neoplasm (HP:0100787)2.14865580
106Lymphoma (HP:0002665)2.14001071
107Clubbing of toes (HP:0100760)2.11931816
108IgA deficiency (HP:0002720)2.11547809
109Proximal tubulopathy (HP:0000114)2.10664467
110Abnormal protein glycosylation (HP:0012346)2.10503080
111Abnormal glycosylation (HP:0012345)2.10503080
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10503080
113Abnormal protein N-linked glycosylation (HP:0012347)2.10503080
114Mediastinal lymphadenopathy (HP:0100721)2.10008520
115Macrocytic anemia (HP:0001972)2.09997229
116Gingivitis (HP:0000230)2.09699293
117Abnormality of polysaccharide metabolism (HP:0011012)2.07157239
118Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07157239
119Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07157239
120Bronchitis (HP:0012387)2.06961747
121Glomerulonephritis (HP:0000099)2.06945009
122Thrombocytosis (HP:0001894)2.05830723
123Stomatitis (HP:0010280)2.03785058
124Vacuolated lymphocytes (HP:0001922)2.03299821
125Restrictive lung disease (HP:0002091)2.02893970
126Acne (HP:0001061)2.01438571
127Skin rash (HP:0000988)2.00942587
128Abnormality of the preputium (HP:0100587)2.00863564
129Amyloidosis (HP:0011034)2.00656491
130Meckel diverticulum (HP:0002245)1.99886664
131Aplastic anemia (HP:0001915)1.99836947
132Aplasia/hypoplasia of the uterus (HP:0008684)1.99653546
133Petechiae (HP:0000967)1.99191103
134Aplasia/Hypoplasia of the uvula (HP:0010293)1.98344719
135Sepsis (HP:0100806)1.98029159
136Osteomyelitis (HP:0002754)1.96558335
137Cleft eyelid (HP:0000625)1.96296209
138Mucopolysacchariduria (HP:0008155)1.96243210
139Abnormality of cells of the lymphoid lineage (HP:0012140)1.95303872
140Lymphopenia (HP:0001888)1.94227449
141Duplicated collecting system (HP:0000081)1.93958633
142Microretrognathia (HP:0000308)1.93133049
143Chronic sinusitis (HP:0011109)1.92908082
144Pallor (HP:0000980)1.92538380
145External ophthalmoplegia (HP:0000544)1.92375427
146Recurrent lower respiratory tract infections (HP:0002783)1.92254251
147Prolonged neonatal jaundice (HP:0006579)1.89648593
148Abnormality of cells of the erythroid lineage (HP:0012130)1.89581230
149Bone marrow hypocellularity (HP:0005528)1.87952168
150Abnormality of the ileum (HP:0001549)1.87508424
151Bronchiectasis (HP:0002110)1.87304742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.68535724
2IRAK43.95443773
3RIPK43.78517607
4STK162.98589458
5PLK42.96749909
6IRAK12.70278407
7TXK2.42187637
8MAP2K32.38331628
9BLK2.31934067
10BUB12.26306199
11MAP4K12.23554183
12TYK22.19421922
13IRAK22.18574246
14MAP3K142.17550724
15ZAK2.11446201
16EIF2AK32.10906313
17IKBKE1.97799090
18MAP3K111.89036835
19TNK21.82172840
20MAP3K31.78007873
21NME21.72559296
22IKBKB1.68526402
23JAK31.62616418
24PRPF4B1.58219682
25GRK61.50283650
26MST41.49635024
27KIT1.48166311
28TESK21.45778276
29EIF2AK11.44989787
30ADRBK21.41687489
31FGFR41.40850176
32RIPK11.40407778
33TEC1.40209174
34GRK11.38576027
35PIM21.37202074
36TBK11.31001403
37SRPK11.30556360
38TLK11.29932238
39VRK11.29617853
40ACVR1B1.26570646
41BMPR1B1.24589318
42PBK1.20138517
43KDR1.18759401
44ZAP701.17626367
45NLK1.17451946
46FGR1.16972232
47EIF2AK21.13024755
48JAK21.11057431
49STK101.01974920
50MAP3K10.99002570
51MAP2K20.98461250
52TAOK10.98254751
53TAOK30.98029463
54BTK0.97429595
55TRIB30.93490025
56WEE10.92428354
57ITK0.92013772
58CHUK0.91930161
59CSF1R0.90939163
60TTK0.88589531
61GRK70.87761225
62LCK0.87732440
63EPHA30.86665169
64JAK10.86001209
65SYK0.85716139
66TIE10.84985054
67CSK0.84265204
68RPS6KA50.84105328
69EPHB10.79567683
70TAOK20.78830575
71TSSK60.78176525
72EPHA20.76854295
73BCKDK0.76341958
74PDK10.75803828
75LYN0.75003506
76PTK60.70749247
77MAPK110.69878849
78MAPK70.69129740
79SIK30.67806138
80BMPR20.66175105
81STK40.65718755
82CDC42BPA0.65325926
83PIM10.63919049
84SMG10.63241200
85MAP3K70.63050792
86MAPK120.62945690
87FES0.62671825
88DYRK30.62635563
89PDPK10.62063731
90MAP3K60.62032282
91MAP3K130.60890636
92CLK10.59930134
93RPS6KA40.59696816
94FYN0.58409640
95PLK10.57940251
96BRSK20.57340528
97PRKD20.56843062
98GRK50.53855052
99PASK0.49946189
100NME10.49829824
101ATR0.49581337
102ABL20.48499043
103MAPKAPK20.47117414
104FGFR30.46912347
105ERN10.46809581
106LRRK20.45979062
107PRKCI0.45835091
108DAPK20.45293997
109SIK20.44274882
110HIPK20.42359632
111PIK3CA0.42254067
112MARK20.41882087
113MARK10.41819958
114HCK0.41146342
115MAP2K60.40407600
116CDK70.40301450
117MAPKAPK30.39378218
118MUSK0.38555553
119MAP3K50.37062985
120CDK120.36971083
121MATK0.35868564
122SIK10.35145783
123PRKCD0.34520671
124AURKB0.33908714
125FLT30.33533407
126CSNK2A10.33308563
127RPS6KL10.32812616
128RPS6KC10.32812616
129MAPK40.31301768
130ABL10.30772529
131MAPK30.29561115
132RET0.29532249
133NEK60.29350851
134RPS6KB20.29283644
135PIK3CG0.28689736
136PKN10.28013400
137PRKG20.27720649
138RPS6KA60.27629781
139TGFBR20.27130666
140PRKCQ0.26224702
141MARK30.25143293
142PAK40.24312642

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.33618332
2Proteasome_Homo sapiens_hsa030503.27381437
3Primary immunodeficiency_Homo sapiens_hsa053402.95000561
4RNA polymerase_Homo sapiens_hsa030202.78727510
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.74854417
6DNA replication_Homo sapiens_hsa030302.68039794
7Protein export_Homo sapiens_hsa030602.37124491
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.34249765
9Homologous recombination_Homo sapiens_hsa034402.31824478
10Mismatch repair_Homo sapiens_hsa034302.16263729
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.12577363
12Allograft rejection_Homo sapiens_hsa053302.05668302
13Pyrimidine metabolism_Homo sapiens_hsa002402.01775222
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.97831847
15Fanconi anemia pathway_Homo sapiens_hsa034601.79970132
16Graft-versus-host disease_Homo sapiens_hsa053321.76212352
17Viral myocarditis_Homo sapiens_hsa054161.69455318
18Antigen processing and presentation_Homo sapiens_hsa046121.69075171
19Autoimmune thyroid disease_Homo sapiens_hsa053201.63969193
20Spliceosome_Homo sapiens_hsa030401.61967275
21Measles_Homo sapiens_hsa051621.61503979
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61114562
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57593806
24Other glycan degradation_Homo sapiens_hsa005111.47405334
25Base excision repair_Homo sapiens_hsa034101.45489136
26Non-homologous end-joining_Homo sapiens_hsa034501.38794733
27Basal transcription factors_Homo sapiens_hsa030221.36652733
28Oxidative phosphorylation_Homo sapiens_hsa001901.35848747
29TNF signaling pathway_Homo sapiens_hsa046681.35188072
30One carbon pool by folate_Homo sapiens_hsa006701.34652512
31Leishmaniasis_Homo sapiens_hsa051401.34136563
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32701997
33Herpes simplex infection_Homo sapiens_hsa051681.31998140
34Nucleotide excision repair_Homo sapiens_hsa034201.28718546
35Asthma_Homo sapiens_hsa053101.28169453
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27378962
37Lysosome_Homo sapiens_hsa041421.25135604
38Folate biosynthesis_Homo sapiens_hsa007901.23698612
39Chemokine signaling pathway_Homo sapiens_hsa040621.21452589
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20527177
41African trypanosomiasis_Homo sapiens_hsa051431.13451165
42Hematopoietic cell lineage_Homo sapiens_hsa046401.05883580
43Parkinsons disease_Homo sapiens_hsa050121.05692818
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04849114
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04782466
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03074205
47Phagosome_Homo sapiens_hsa041451.02972869
48Arachidonic acid metabolism_Homo sapiens_hsa005901.02855499
49Epstein-Barr virus infection_Homo sapiens_hsa051691.02245828
50Purine metabolism_Homo sapiens_hsa002301.00904986
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99229309
52RNA degradation_Homo sapiens_hsa030180.99147724
53Acute myeloid leukemia_Homo sapiens_hsa052210.98876276
54p53 signaling pathway_Homo sapiens_hsa041150.98597860
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98579335
56T cell receptor signaling pathway_Homo sapiens_hsa046600.97946643
57Staphylococcus aureus infection_Homo sapiens_hsa051500.97315562
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95313930
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94389497
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94217362
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93959141
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90174551
63Sphingolipid metabolism_Homo sapiens_hsa006000.89526216
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.89211985
65RNA transport_Homo sapiens_hsa030130.87662487
66Salmonella infection_Homo sapiens_hsa051320.87623345
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87550375
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.84458932
69Complement and coagulation cascades_Homo sapiens_hsa046100.84158956
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83781438
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.82744393
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81806339
73Huntingtons disease_Homo sapiens_hsa050160.79888426
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.79245194
75Pertussis_Homo sapiens_hsa051330.79168545
76Histidine metabolism_Homo sapiens_hsa003400.78548369
77Platelet activation_Homo sapiens_hsa046110.78329048
78Linoleic acid metabolism_Homo sapiens_hsa005910.78269643
79Influenza A_Homo sapiens_hsa051640.73986619
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71939510
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70559503
82Legionellosis_Homo sapiens_hsa051340.70422493
83Vitamin B6 metabolism_Homo sapiens_hsa007500.68489939
84Type I diabetes mellitus_Homo sapiens_hsa049400.68320464
85Rheumatoid arthritis_Homo sapiens_hsa053230.67823042
86Hepatitis B_Homo sapiens_hsa051610.65848620
87Phenylalanine metabolism_Homo sapiens_hsa003600.62384655
88Glutathione metabolism_Homo sapiens_hsa004800.61199164
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61003569
90Osteoclast differentiation_Homo sapiens_hsa043800.60209065
91Renin-angiotensin system_Homo sapiens_hsa046140.59319753
92Alzheimers disease_Homo sapiens_hsa050100.58397480
93Pentose phosphate pathway_Homo sapiens_hsa000300.58300233
94Apoptosis_Homo sapiens_hsa042100.56972977
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52879860
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.51492056
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51028952
98Hepatitis C_Homo sapiens_hsa051600.50909951
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50811957
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50400843
101Cell cycle_Homo sapiens_hsa041100.50111437
102B cell receptor signaling pathway_Homo sapiens_hsa046620.49960632
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49593068
104Tyrosine metabolism_Homo sapiens_hsa003500.48263021
105ABC transporters_Homo sapiens_hsa020100.48216305
106Metabolic pathways_Homo sapiens_hsa011000.48112818
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46915881
108Fatty acid elongation_Homo sapiens_hsa000620.46844879
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.46811617
110Caffeine metabolism_Homo sapiens_hsa002320.46367332
111Shigellosis_Homo sapiens_hsa051310.44612700
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.44579421
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44549594
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43310312
115Steroid biosynthesis_Homo sapiens_hsa001000.43295302
116Malaria_Homo sapiens_hsa051440.43053143
117Ether lipid metabolism_Homo sapiens_hsa005650.42904492
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41161129
119Sulfur metabolism_Homo sapiens_hsa009200.40295186
120Collecting duct acid secretion_Homo sapiens_hsa049660.39745871
121Tuberculosis_Homo sapiens_hsa051520.38852340
122Systemic lupus erythematosus_Homo sapiens_hsa053220.38570778
123HTLV-I infection_Homo sapiens_hsa051660.38443219
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.38039001
125Chemical carcinogenesis_Homo sapiens_hsa052040.37907208
126Toxoplasmosis_Homo sapiens_hsa051450.37772269
127Viral carcinogenesis_Homo sapiens_hsa052030.36986823
128Fructose and mannose metabolism_Homo sapiens_hsa000510.36974311
129Insulin resistance_Homo sapiens_hsa049310.36637453
130Non-small cell lung cancer_Homo sapiens_hsa052230.36553629
131Prolactin signaling pathway_Homo sapiens_hsa049170.36313607
132Galactose metabolism_Homo sapiens_hsa000520.34836458
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.34058508
134VEGF signaling pathway_Homo sapiens_hsa043700.33620200
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32863696
136Endocytosis_Homo sapiens_hsa041440.32252596
137Amoebiasis_Homo sapiens_hsa051460.32221094
138Primary bile acid biosynthesis_Homo sapiens_hsa001200.31113728
139Prion diseases_Homo sapiens_hsa050200.30914598
140Pancreatic cancer_Homo sapiens_hsa052120.30869304
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29657570
142PPAR signaling pathway_Homo sapiens_hsa033200.27608345
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25163361
144Glycerolipid metabolism_Homo sapiens_hsa005610.23049567
145Chronic myeloid leukemia_Homo sapiens_hsa052200.22992630
146Retinol metabolism_Homo sapiens_hsa008300.20400857

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