TARBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of granulocyte differentiation (GO:0030854)5.35451384
2poly(A)+ mRNA export from nucleus (GO:0016973)4.92141798
3regulation of female gonad development (GO:2000194)4.77757904
4response to pheromone (GO:0019236)4.65623497
5interkinetic nuclear migration (GO:0022027)4.51853567
6mucosal-associated lymphoid tissue development (GO:0048537)4.49348986
7Peyers patch development (GO:0048541)4.49348986
8negative regulation of thymocyte apoptotic process (GO:0070244)4.27310307
9monoubiquitinated protein deubiquitination (GO:0035520)4.12867500
10definitive hemopoiesis (GO:0060216)4.11587073
11V(D)J recombination (GO:0033151)4.08966336
12positive regulation of B cell differentiation (GO:0045579)3.93915401
13histone H3-K4 trimethylation (GO:0080182)3.91697605
14histone H4-K16 acetylation (GO:0043984)3.90317907
15cilium or flagellum-dependent cell motility (GO:0001539)3.73569946
16cellular response to ethanol (GO:0071361)3.71332557
17B cell receptor signaling pathway (GO:0050853)3.67134479
18regulation of protein polyubiquitination (GO:1902914)3.58595225
19positive regulation of dendritic spine morphogenesis (GO:0061003)3.57872246
20positive regulation of histone H3-K4 methylation (GO:0051571)3.55964515
21piRNA metabolic process (GO:0034587)3.52966090
22dosage compensation (GO:0007549)3.51814540
23necroptotic process (GO:0070266)3.45895155
24histone H4-K5 acetylation (GO:0043981)3.42059981
25histone H4-K8 acetylation (GO:0043982)3.42059981
26ribosomal small subunit assembly (GO:0000028)3.39970479
27regulation of granulocyte differentiation (GO:0030852)3.31112183
28negative regulation of neurotransmitter secretion (GO:0046929)3.30667101
29mRNA splice site selection (GO:0006376)3.27517461
30regulation of histone H3-K9 methylation (GO:0051570)3.27480334
31negative regulation of cell cycle G2/M phase transition (GO:1902750)3.22530126
32forebrain morphogenesis (GO:0048853)3.21468933
33regulation of B cell receptor signaling pathway (GO:0050855)3.20036413
34RNA destabilization (GO:0050779)3.19644071
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.19186616
36hematopoietic stem cell proliferation (GO:0071425)3.11137162
37B cell differentiation (GO:0030183)3.09916894
38regulation of B cell differentiation (GO:0045577)3.08253793
39histone H3-K9 methylation (GO:0051567)3.07631194
40regulation of RNA export from nucleus (GO:0046831)3.07411468
41phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.07286713
42regulation of histone H3-K4 methylation (GO:0051569)3.03923498
43DNA topological change (GO:0006265)3.03486475
44positive regulation of gamma-delta T cell activation (GO:0046645)3.03098401
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.00268284
46positive T cell selection (GO:0043368)2.98234308
47T cell lineage commitment (GO:0002360)2.91822690
48mature B cell differentiation involved in immune response (GO:0002313)2.88516390
49DNA unwinding involved in DNA replication (GO:0006268)2.87868479
50negative regulation of erythrocyte differentiation (GO:0045647)2.87851500
51gene silencing by RNA (GO:0031047)2.87493663
52peptidyl-lysine trimethylation (GO:0018023)2.84170292
53negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.83857256
54negative regulation of T-helper cell differentiation (GO:0045623)2.83857256
55inositol metabolic process (GO:0006020)2.83584361
56T cell differentiation in thymus (GO:0033077)2.83578073
57positive regulation of vasculogenesis (GO:2001214)2.83158301
58regulation of T-helper 1 cell differentiation (GO:0045625)2.82545217
59sister chromatid cohesion (GO:0007062)2.78783399
60regulation of gamma-delta T cell differentiation (GO:0045586)2.77784061
61negative regulation of gene expression, epigenetic (GO:0045814)2.77274451
62positive regulation of histone methylation (GO:0031062)2.75610828
63positive thymic T cell selection (GO:0045059)2.75593914
64lymphoid progenitor cell differentiation (GO:0002320)2.73863838
65epithelial cell differentiation involved in kidney development (GO:0035850)2.71729595
66mature B cell differentiation (GO:0002335)2.70011405
67necrotic cell death (GO:0070265)2.65879961
68DNA methylation involved in gamete generation (GO:0043046)2.65509859
69histone lysine methylation (GO:0034968)2.65409440
70viral transcription (GO:0019083)2.64521015
71formation of translation preinitiation complex (GO:0001731)2.63655648
72positive regulation of Rap GTPase activity (GO:0032854)2.62380942
73megakaryocyte development (GO:0035855)2.62368755
74purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.61546995
75DNA duplex unwinding (GO:0032508)2.60579307
76DNA alkylation (GO:0006305)2.60071654
77DNA methylation (GO:0006306)2.60071654
78regulation of thymocyte apoptotic process (GO:0070243)2.58636494
79mast cell degranulation (GO:0043303)2.58514084
80mast cell activation involved in immune response (GO:0002279)2.58514084
81alternative mRNA splicing, via spliceosome (GO:0000380)2.58278427
82phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.58092289
83peptidyl-lysine methylation (GO:0018022)2.57696804
84negative regulation of neurotransmitter transport (GO:0051589)2.57135195
85translational termination (GO:0006415)2.57113098
86stress granule assembly (GO:0034063)2.56561394
87protein localization to Golgi apparatus (GO:0034067)2.55876672
88B cell activation (GO:0042113)2.55834819
89pyrimidine dimer repair (GO:0006290)2.55210457
90rRNA catabolic process (GO:0016075)2.54651638
91regulation of histone methylation (GO:0031060)2.53663010
92histone H3-K9 modification (GO:0061647)2.52382064
93DNA geometric change (GO:0032392)2.52256497
94purine deoxyribonucleotide metabolic process (GO:0009151)2.50590743
95histone H3-K4 methylation (GO:0051568)2.49518162
96regulation of necroptotic process (GO:0060544)2.49237648
97positive regulation of protein deacetylation (GO:0090312)2.49061576
98positive regulation by host of viral transcription (GO:0043923)2.48363834
99phosphorylated carbohydrate dephosphorylation (GO:0046838)2.47052072
100inositol phosphate dephosphorylation (GO:0046855)2.47052072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.19686103
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.15219092
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.88124468
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.87005198
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.84010533
6GATA1_22025678_ChIP-Seq_K562_Human3.72563973
7* FUS_26573619_Chip-Seq_HEK293_Human2.92041536
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.80999898
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.68474938
10SCL_19346495_ChIP-Seq_HPC-7_Human2.67289706
11ZNF274_21170338_ChIP-Seq_K562_Hela2.64274938
12CIITA_25753668_ChIP-Seq_RAJI_Human2.46028513
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39057591
14* MYC_22102868_ChIP-Seq_BL_Human2.30467838
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24446204
16EWS_26573619_Chip-Seq_HEK293_Human2.11807864
17RUNX_20019798_ChIP-Seq_JUKART_Human2.04322913
18MYB_26560356_Chip-Seq_TH2_Human1.99341867
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98986678
20EGR1_19374776_ChIP-ChIP_THP-1_Human1.92200934
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86903297
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81011308
23* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.77891322
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73352944
25GATA3_27048872_Chip-Seq_THYMUS_Human1.63592200
26PKCTHETA_26484144_Chip-Seq_BREAST_Human1.63352761
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62166153
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.61275619
29E2F7_22180533_ChIP-Seq_HELA_Human1.60706486
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58730612
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57347351
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53324676
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51907834
34ER_23166858_ChIP-Seq_MCF-7_Human1.49146245
35* VDR_21846776_ChIP-Seq_THP-1_Human1.41512506
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38253812
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38215282
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36254306
39FOXP3_21729870_ChIP-Seq_TREG_Human1.34681937
40GBX2_23144817_ChIP-Seq_PC3_Human1.32608549
41TAF15_26573619_Chip-Seq_HEK293_Human1.29288632
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29220888
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28487073
44TCF4_23295773_ChIP-Seq_U87_Human1.27820593
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27279014
46MYB_26560356_Chip-Seq_TH1_Human1.27079883
47STAT3_23295773_ChIP-Seq_U87_Human1.26324630
48* VDR_24763502_ChIP-Seq_THP-1_Human1.25173611
49IRF1_19129219_ChIP-ChIP_H3396_Human1.20216132
50PRDM14_20953172_ChIP-Seq_ESCs_Human1.19672057
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19470345
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19470345
53VDR_23849224_ChIP-Seq_CD4+_Human1.17430330
54VDR_22108803_ChIP-Seq_LS180_Human1.17375266
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16512875
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16371742
57CBP_20019798_ChIP-Seq_JUKART_Human1.16371742
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13613649
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.12318788
60RNF2_27304074_Chip-Seq_NSC_Mouse1.09888221
61KDM5A_27292631_Chip-Seq_BREAST_Human1.08757324
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08754123
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07316013
64DROSHA_22980978_ChIP-Seq_HELA_Human1.06743062
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.05730718
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.05278921
67SMAD4_21799915_ChIP-Seq_A2780_Human1.04833859
68* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04801498
69AR_21572438_ChIP-Seq_LNCaP_Human1.02806200
70* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02424843
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00914476
72TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.00115396
73MYC_18940864_ChIP-ChIP_HL60_Human0.98104724
74CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96300331
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94824309
76* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93804846
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93532618
78* VDR_24787735_ChIP-Seq_THP-1_Human0.93469410
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91946770
80E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91368090
81ETS1_22383799_ChIP-Seq_G1ME_Mouse0.90895484
82* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.88551756
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88084802
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87855832
85UTX_26944678_Chip-Seq_JUKART_Human0.87437458
86* RUNX2_22187159_ChIP-Seq_PCA_Human0.87025762
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86704613
88FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86461729
89GATA3_26560356_Chip-Seq_TH2_Human0.86417051
90AR_25329375_ChIP-Seq_VCAP_Human0.86170550
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85500813
92SPI1_23547873_ChIP-Seq_NB4_Human0.85436921
93TCF7_22412390_ChIP-Seq_EML_Mouse0.84153070
94PCGF2_27294783_Chip-Seq_ESCs_Mouse0.83921637
95FLI1_21867929_ChIP-Seq_TH2_Mouse0.83770832
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83677233
97GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82032015
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81743801
99BP1_19119308_ChIP-ChIP_Hs578T_Human0.81583105
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80509131

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.80749261
2MP0008057_abnormal_DNA_replication3.53978924
3MP0009278_abnormal_bone_marrow2.97885129
4MP0006292_abnormal_olfactory_placode2.84119762
5MP0002009_preneoplasia2.77336036
6MP0004808_abnormal_hematopoietic_stem2.72393075
7MP0001835_abnormal_antigen_presentation2.65054403
8MP0008877_abnormal_DNA_methylation2.57644541
9MP0002166_altered_tumor_susceptibility2.54604416
10MP0002876_abnormal_thyroid_physiology2.54216956
11MP0010094_abnormal_chromosome_stability2.50485390
12MP0003787_abnormal_imprinting2.45922986
13MP0002132_abnormal_respiratory_system2.37672246
14MP0001545_abnormal_hematopoietic_system2.23271883
15MP0005397_hematopoietic_system_phenotyp2.23271883
16MP0005646_abnormal_pituitary_gland2.21101250
17MP0009697_abnormal_copulation1.94573885
18MP0003763_abnormal_thymus_physiology1.91311446
19MP0005645_abnormal_hypothalamus_physiol1.90271845
20MP0001188_hyperpigmentation1.78070444
21MP0002006_tumorigenesis1.74769632
22MP0000703_abnormal_thymus_morphology1.72621980
23MP0005075_abnormal_melanosome_morpholog1.72141730
24MP0001986_abnormal_taste_sensitivity1.67686471
25MP0003943_abnormal_hepatobiliary_system1.58697108
26MP0002138_abnormal_hepatobiliary_system1.57402980
27MP0002398_abnormal_bone_marrow1.56591907
28MP0005220_abnormal_exocrine_pancreas1.49170296
29MP0008058_abnormal_DNA_repair1.45830902
30MP0001800_abnormal_humoral_immune1.45109683
31MP0010155_abnormal_intestine_physiology1.40423991
32MP0003183_abnormal_peptide_metabolism1.38073649
33MP0004043_abnormal_pH_regulation1.29183638
34MP0000689_abnormal_spleen_morphology1.22472563
35MP0004147_increased_porphyrin_level1.18753509
36MP0000383_abnormal_hair_follicle1.18631050
37MP0002722_abnormal_immune_system1.16725491
38MP0001968_abnormal_touch/_nociception1.14059511
39MP0000716_abnormal_immune_system1.13972701
40MP0000681_abnormal_thyroid_gland1.13902281
41MP0000685_abnormal_immune_system1.09721183
42MP0008007_abnormal_cellular_replicative1.09121717
43MP0001764_abnormal_homeostasis1.08348719
44MP0000631_abnormal_neuroendocrine_gland1.02772354
45MP0004084_abnormal_cardiac_muscle1.01778156
46MP0001177_atelectasis1.01354524
47MP0002429_abnormal_blood_cell1.00668778
48MP0002019_abnormal_tumor_incidence0.98532515
49MP0001486_abnormal_startle_reflex0.98311874
50MP0008995_early_reproductive_senescence0.98153985
51MP0002420_abnormal_adaptive_immunity0.97891241
52MP0003121_genomic_imprinting0.97631194
53MP0001819_abnormal_immune_cell0.94898197
54MP0003656_abnormal_erythrocyte_physiolo0.92391836
55MP0003698_abnormal_male_reproductive0.91377625
56MP0002127_abnormal_cardiovascular_syste0.87295818
57MP0003567_abnormal_fetal_cardiomyocyte0.87194524
58MP0003252_abnormal_bile_duct0.86758069
59MP0003880_abnormal_central_pattern0.85809345
60MP0001873_stomach_inflammation0.84623159
61MP0002723_abnormal_immune_serum0.83465280
62MP0001790_abnormal_immune_system0.82827196
63MP0005387_immune_system_phenotype0.82827196
64MP0002735_abnormal_chemical_nociception0.82630178
65MP0001929_abnormal_gametogenesis0.77481350
66MP0002405_respiratory_system_inflammati0.75399437
67MP0002095_abnormal_skin_pigmentation0.75345956
68MP0001191_abnormal_skin_condition0.74589174
69MP0000013_abnormal_adipose_tissue0.73496604
70MP0002452_abnormal_antigen_presenting0.73038578
71MP0003806_abnormal_nucleotide_metabolis0.70211023
72MP0004130_abnormal_muscle_cell0.68754550
73MP0003890_abnormal_embryonic-extraembry0.68234068
74MP0001879_abnormal_lymphatic_vessel0.67378369
75MP0002928_abnormal_bile_duct0.63914917
76MP0005000_abnormal_immune_tolerance0.63131690
77MP0000313_abnormal_cell_death0.63019642
78MP0003718_maternal_effect0.61164949
79MP0005671_abnormal_response_to0.60404578
80MP0005464_abnormal_platelet_physiology0.60267345
81MP0004782_abnormal_surfactant_physiolog0.59475239
82MP0008775_abnormal_heart_ventricle0.59395840
83MP0000462_abnormal_digestive_system0.58839238
84MP0000372_irregular_coat_pigmentation0.58491779
85MP0001145_abnormal_male_reproductive0.57703585
86MP0002083_premature_death0.57693991
87MP0000350_abnormal_cell_proliferation0.56944062
88MP0000653_abnormal_sex_gland0.56386386
89MP0000598_abnormal_liver_morphology0.55619320
90MP0003635_abnormal_synaptic_transmissio0.55189234
91MP0005551_abnormal_eye_electrophysiolog0.55112121
92MP0004859_abnormal_synaptic_plasticity0.54887252
93MP0002160_abnormal_reproductive_system0.54210340
94MP0002210_abnormal_sex_determination0.53652255
95MP0000566_synostosis0.53492660
96MP0001943_abnormal_respiration0.53097611
97MP0003077_abnormal_cell_cycle0.51337327
98MP0002084_abnormal_developmental_patter0.51261592
99MP0000955_abnormal_spinal_cord0.50912391
100MP0008872_abnormal_physiological_respon0.49946167

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)8.29824823
2Abnormality of B cell number (HP:0010975)8.05342903
3Panhypogammaglobulinemia (HP:0003139)7.46251284
4Acute lymphatic leukemia (HP:0006721)6.15815861
5Severe combined immunodeficiency (HP:0004430)6.13408055
6Hypoplasia of the thymus (HP:0000778)5.49067175
7Thyroiditis (HP:0100646)5.18236457
8Combined immunodeficiency (HP:0005387)4.64325931
9Agammaglobulinemia (HP:0004432)4.14727472
10Hypoproteinemia (HP:0003075)3.51551210
11Recurrent viral infections (HP:0004429)3.45439052
12Acute myeloid leukemia (HP:0004808)3.32620710
13Eosinophilia (HP:0001880)3.29664782
14Granulocytopenia (HP:0001913)3.26935499
15Recurrent fungal infections (HP:0002841)2.88843477
16Abnormality of eosinophils (HP:0001879)2.80064090
17Abnormal delayed hypersensitivity skin test (HP:0002963)2.71450538
18T lymphocytopenia (HP:0005403)2.70282672
19Aplasia/Hypoplasia of the thymus (HP:0010515)2.68058250
20Neonatal respiratory distress (HP:0002643)2.60458991
21Abnormality of the fingertips (HP:0001211)2.56124622
22Abnormality of the prostate (HP:0008775)2.54121766
23Chronic hepatic failure (HP:0100626)2.49968789
24Central scotoma (HP:0000603)2.49213706
25Papilledema (HP:0001085)2.46317569
26Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.44552768
27Diastasis recti (HP:0001540)2.43081562
28Abnormality of T cell number (HP:0011839)2.42115493
29Limb hypertonia (HP:0002509)2.42057210
30Meningitis (HP:0001287)2.33652756
31Chronic mucocutaneous candidiasis (HP:0002728)2.29165798
32Recurrent cutaneous fungal infections (HP:0011370)2.29165798
33Prostate neoplasm (HP:0100787)2.27428433
34Hypoplastic iliac wings (HP:0002866)2.26643505
35Autoimmune hemolytic anemia (HP:0001890)2.26127206
36Abnormality of the thymus (HP:0000777)2.20638052
37Volvulus (HP:0002580)2.18566634
38Brushfield spots (HP:0001088)2.17061640
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10900506
40Abnormality of T cells (HP:0002843)2.10900372
41Abnormality of the phalanges of the 2nd finger (HP:0009541)2.09367496
42Erythroderma (HP:0001019)2.09030950
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.07232309
44Absent/shortened dynein arms (HP:0200106)2.07232309
45Colitis (HP:0002583)2.07023664
46Papillary thyroid carcinoma (HP:0002895)2.02245689
47Abnormal rod and cone electroretinograms (HP:0008323)1.97736958
48Ankyloglossia (HP:0010296)1.96030231
49Abnormality of the pubic bones (HP:0003172)1.92996685
50Carpal bone hypoplasia (HP:0001498)1.90952946
51Metaphyseal dysplasia (HP:0100255)1.89069266
52Stomach cancer (HP:0012126)1.88034283
53Nephronophthisis (HP:0000090)1.87010808
54IgG deficiency (HP:0004315)1.85317673
55Abnormality of macular pigmentation (HP:0008002)1.79738420
56Thrombocytosis (HP:0001894)1.78944058
57Enlarged epiphyses (HP:0010580)1.77998618
58Cutis marmorata (HP:0000965)1.77887703
59Macroorchidism (HP:0000053)1.77799098
60Abnormality of cells of the erythroid lineage (HP:0012130)1.77501710
61Leukocytosis (HP:0001974)1.77380021
6211 pairs of ribs (HP:0000878)1.73443693
63Abnormality of T cell physiology (HP:0011840)1.71850748
64Cerebellar dysplasia (HP:0007033)1.71739366
65Inflammation of the large intestine (HP:0002037)1.70296246
66Abnormality of male internal genitalia (HP:0000022)1.68561401
67Relative macrocephaly (HP:0004482)1.68294714
68Polygenic inheritance (HP:0010982)1.67631816
69Submucous cleft hard palate (HP:0000176)1.65083106
70Abnormality of the renal medulla (HP:0100957)1.65028703
71Gastrointestinal inflammation (HP:0004386)1.64365025
72Truncal obesity (HP:0001956)1.63187786
73Chronic sinusitis (HP:0011109)1.63172999
74Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.63120945
75Febrile seizures (HP:0002373)1.63018595
76Thickened nuchal skin fold (HP:0000474)1.62297071
77Asplenia (HP:0001746)1.61029532
78Gonadal dysgenesis (HP:0000133)1.60430203
79Thoracic kyphosis (HP:0002942)1.59618836
80Abnormal number of erythroid precursors (HP:0012131)1.59194908
81Abnormality of the periventricular white matter (HP:0002518)1.58713435
82Aplasia/Hypoplasia of the spleen (HP:0010451)1.57668349
83Severe global developmental delay (HP:0011344)1.56931324
84Pancreatic fibrosis (HP:0100732)1.56592933
85Short foot (HP:0001773)1.55049213
86Gaze-evoked nystagmus (HP:0000640)1.54737163
87Medial flaring of the eyebrow (HP:0010747)1.54697375
88Sandal gap (HP:0001852)1.53764767
89Recurrent bronchitis (HP:0002837)1.53597378
90Pancreatic cysts (HP:0001737)1.52629395
91Abnormality of DNA repair (HP:0003254)1.50934262
92Abnormal biliary tract physiology (HP:0012439)1.50652179
93Bile duct proliferation (HP:0001408)1.50652179
94Broad palm (HP:0001169)1.49560122
95Partial agenesis of the corpus callosum (HP:0001338)1.49125523
96Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.48606319
97Congenital stationary night blindness (HP:0007642)1.48572446
98Elevated erythrocyte sedimentation rate (HP:0003565)1.48432602
99Barrel-shaped chest (HP:0001552)1.47473947
100Thickened calvaria (HP:0002684)1.46877107

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT33.96874219
2KIT3.70975429
3AKT32.71573596
4TAOK32.42633218
5CDC72.36018739
6TEC2.22035684
7BRD42.03580591
8MAP3K132.00354499
9CSF1R1.86249787
10MKNK11.85140849
11NUAK11.77631681
12PRKD31.75097280
13MAP4K11.74105973
14FRK1.64507213
15TNK21.50215868
16CDK121.49125470
17RIPK41.48499318
18MKNK21.42797107
19NLK1.41175911
20SYK1.40400164
21EEF2K1.39778394
22MAP3K141.39161832
23FES1.39004219
24EIF2AK31.37812975
25BTK1.36099510
26CDK191.35612333
27CAMK1G1.35420669
28TXK1.33123422
29PNCK1.29707533
30RPS6KB21.25934215
31CDK31.23055590
32ITK1.22911606
33MAP3K71.21162346
34SGK21.17882028
35TAF11.16795945
36PASK1.15750050
37CCNB11.11209458
38ATR1.06443394
39TGFBR11.05771514
40MAP3K101.04824060
41CDK61.00246259
42MAPK130.98880068
43CAMK1D0.96212119
44SCYL20.90913941
45HCK0.89995147
46MAP2K60.89446100
47SIK20.86616236
48PINK10.84720042
49CDK40.83258547
50MAP2K30.82962576
51STK110.81737572
52CAMKK10.80047133
53FGFR30.79751154
54RPS6KB10.78808346
55MAP2K20.77966651
56ATM0.76279129
57PRKCH0.75396895
58NTRK30.75030174
59BMPR1B0.74671485
60DYRK1A0.71654009
61DAPK20.69442004
62LCK0.68016771
63ZAK0.67535863
64BRSK20.65802603
65HIPK20.65537896
66CAMKK20.64528315
67CDK90.63339826
68MAP2K40.62677385
69SGK4940.62276862
70SGK2230.62276862
71EIF2AK20.61885933
72MAP4K20.61815479
73PIK3CG0.61493523
74MATK0.61279170
75PRKCQ0.60440999
76SGK30.59552541
77CLK10.59344541
78SGK10.56716399
79EPHA40.56132432
80CDK70.55707973
81LYN0.54377778
82TRIB30.54251279
83MAPKAPK50.53836840
84WNK40.53053627
85CDK20.51731494
86MAP3K60.50777954
87BMPR20.50419048
88TNIK0.50156282
89RPS6KA60.47777342
90CHEK10.47729507
91MAPK100.47653536
92MAPK30.45538797
93WNK10.45490602
94RPS6KC10.42595801
95RPS6KL10.42595801
96FGFR20.42394048
97STK390.40416790
98JAK30.38389356
99MAPK150.37964365
100PDK10.37490361

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.64959746
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.46492150
3Primary immunodeficiency_Homo sapiens_hsa053403.28962094
4Asthma_Homo sapiens_hsa053102.55535355
5B cell receptor signaling pathway_Homo sapiens_hsa046622.08804729
6Selenocompound metabolism_Homo sapiens_hsa004502.05396485
7Phosphatidylinositol signaling system_Homo sapiens_hsa040701.82615413
8Allograft rejection_Homo sapiens_hsa053301.77202565
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.59410875
10Inositol phosphate metabolism_Homo sapiens_hsa005621.56584176
11Base excision repair_Homo sapiens_hsa034101.52304616
12Autoimmune thyroid disease_Homo sapiens_hsa053201.49779684
13Type I diabetes mellitus_Homo sapiens_hsa049401.43956181
14Linoleic acid metabolism_Homo sapiens_hsa005911.42895498
15mRNA surveillance pathway_Homo sapiens_hsa030151.41854271
16Acute myeloid leukemia_Homo sapiens_hsa052211.39755756
17Ether lipid metabolism_Homo sapiens_hsa005651.39577852
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35584902
19Transcriptional misregulation in cancer_Homo sapiens_hsa052021.35549653
20Graft-versus-host disease_Homo sapiens_hsa053321.34610231
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32715266
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26151092
23Homologous recombination_Homo sapiens_hsa034401.23307535
24Long-term depression_Homo sapiens_hsa047301.21016119
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.18808102
26Fanconi anemia pathway_Homo sapiens_hsa034601.16454190
27Dorso-ventral axis formation_Homo sapiens_hsa043201.14946853
28Platelet activation_Homo sapiens_hsa046111.11468765
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11128795
30mTOR signaling pathway_Homo sapiens_hsa041501.09208528
31Non-small cell lung cancer_Homo sapiens_hsa052231.05398386
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05079279
33Phototransduction_Homo sapiens_hsa047441.00255940
34Ribosome_Homo sapiens_hsa030100.97553020
35RNA transport_Homo sapiens_hsa030130.96783915
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95898459
37Leishmaniasis_Homo sapiens_hsa051400.94634173
38Chronic myeloid leukemia_Homo sapiens_hsa052200.93736714
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92752119
40Nucleotide excision repair_Homo sapiens_hsa034200.92114572
41Choline metabolism in cancer_Homo sapiens_hsa052310.91954253
42Taste transduction_Homo sapiens_hsa047420.91434090
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89850423
44Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89253828
45T cell receptor signaling pathway_Homo sapiens_hsa046600.87626590
46RNA degradation_Homo sapiens_hsa030180.85246057
47Long-term potentiation_Homo sapiens_hsa047200.84800838
48Lysine degradation_Homo sapiens_hsa003100.83784426
49Antigen processing and presentation_Homo sapiens_hsa046120.82556818
50Purine metabolism_Homo sapiens_hsa002300.81746571
51Glutamatergic synapse_Homo sapiens_hsa047240.80199096
52Nitrogen metabolism_Homo sapiens_hsa009100.77954010
53Renin secretion_Homo sapiens_hsa049240.77509729
54VEGF signaling pathway_Homo sapiens_hsa043700.74294759
55DNA replication_Homo sapiens_hsa030300.73662494
56Circadian entrainment_Homo sapiens_hsa047130.73236750
57Oxytocin signaling pathway_Homo sapiens_hsa049210.73144134
58Hematopoietic cell lineage_Homo sapiens_hsa046400.72906496
59Herpes simplex infection_Homo sapiens_hsa051680.72551141
60Calcium signaling pathway_Homo sapiens_hsa040200.71272202
61Butanoate metabolism_Homo sapiens_hsa006500.68990942
62ABC transporters_Homo sapiens_hsa020100.67825294
63Regulation of autophagy_Homo sapiens_hsa041400.67452851
64One carbon pool by folate_Homo sapiens_hsa006700.67191460
65Glycerolipid metabolism_Homo sapiens_hsa005610.67004763
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65758335
67Nicotine addiction_Homo sapiens_hsa050330.65139999
68Olfactory transduction_Homo sapiens_hsa047400.64305567
69Ovarian steroidogenesis_Homo sapiens_hsa049130.63824244
70Glucagon signaling pathway_Homo sapiens_hsa049220.62319386
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61808451
72Influenza A_Homo sapiens_hsa051640.61279580
73Amphetamine addiction_Homo sapiens_hsa050310.60530508
74Salivary secretion_Homo sapiens_hsa049700.60293436
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56475916
76Peroxisome_Homo sapiens_hsa041460.56279321
77Morphine addiction_Homo sapiens_hsa050320.55533972
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.55237489
79Systemic lupus erythematosus_Homo sapiens_hsa053220.55018798
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54105768
81Spliceosome_Homo sapiens_hsa030400.54077955
82Pancreatic cancer_Homo sapiens_hsa052120.53727325
83FoxO signaling pathway_Homo sapiens_hsa040680.53011772
84Other glycan degradation_Homo sapiens_hsa005110.52409958
85Serotonergic synapse_Homo sapiens_hsa047260.52166001
86Prolactin signaling pathway_Homo sapiens_hsa049170.51477011
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50117373
88Cholinergic synapse_Homo sapiens_hsa047250.49929725
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49760385
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49387368
91Toxoplasmosis_Homo sapiens_hsa051450.49076698
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48783889
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.48685350
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47385507
95Insulin resistance_Homo sapiens_hsa049310.46807274
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.46090135
97Colorectal cancer_Homo sapiens_hsa052100.45193292
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44424810
99Sulfur metabolism_Homo sapiens_hsa009200.43520658
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.43334838

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