TARDBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.31720009
2nuclear pore organization (GO:0006999)5.29045802
3DNA unwinding involved in DNA replication (GO:0006268)5.27248429
4pre-miRNA processing (GO:0031054)5.18492422
5mitotic sister chromatid cohesion (GO:0007064)5.04723720
6establishment of integrated proviral latency (GO:0075713)4.79210956
7protein localization to kinetochore (GO:0034501)4.71759824
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.61851271
9negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.50545679
10DNA ligation (GO:0006266)4.35113361
11DNA strand elongation (GO:0022616)4.23971169
12sister chromatid segregation (GO:0000819)4.17196357
13negative regulation of histone methylation (GO:0031061)4.13739717
14chromatin remodeling at centromere (GO:0031055)4.07197863
15negative regulation of RNA splicing (GO:0033119)4.06550712
16CENP-A containing nucleosome assembly (GO:0034080)4.05753256
17regulation of sister chromatid cohesion (GO:0007063)4.05067172
18mitotic chromosome condensation (GO:0007076)4.03159903
19regulation of RNA export from nucleus (GO:0046831)3.99569433
20negative regulation of mRNA processing (GO:0050686)3.94470499
21mitotic nuclear envelope disassembly (GO:0007077)3.93578655
22telomere maintenance via semi-conservative replication (GO:0032201)3.89115409
23DNA replication-dependent nucleosome organization (GO:0034723)3.87166767
24DNA replication-dependent nucleosome assembly (GO:0006335)3.87166767
25protein localization to chromosome, centromeric region (GO:0071459)3.85532035
26heterochromatin organization (GO:0070828)3.84259226
27pore complex assembly (GO:0046931)3.82305947
28DNA duplex unwinding (GO:0032508)3.78073874
29nuclear envelope disassembly (GO:0051081)3.78065419
30membrane disassembly (GO:0030397)3.78065419
31DNA geometric change (GO:0032392)3.76295973
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.73223072
33mitotic sister chromatid segregation (GO:0000070)3.71189081
34negative regulation of mRNA metabolic process (GO:1903312)3.67204305
35peptidyl-lysine dimethylation (GO:0018027)3.66634311
36regulation of spindle organization (GO:0090224)3.59224713
37mitotic metaphase plate congression (GO:0007080)3.58450088
38histone exchange (GO:0043486)3.55541033
39regulation of histone H3-K9 methylation (GO:0051570)3.53395695
40glucocorticoid receptor signaling pathway (GO:0042921)3.50389512
41DNA replication checkpoint (GO:0000076)3.48018926
42folic acid-containing compound biosynthetic process (GO:0009396)3.43025699
43double-strand break repair via nonhomologous end joining (GO:0006303)3.41980058
44non-recombinational repair (GO:0000726)3.41980058
45regulation of mitotic spindle organization (GO:0060236)3.40788965
46positive regulation of chromosome segregation (GO:0051984)3.39348876
47IMP metabolic process (GO:0046040)3.38230355
48establishment of viral latency (GO:0019043)3.36883168
49mitotic recombination (GO:0006312)3.36023137
50paraxial mesoderm development (GO:0048339)3.35425657
51telomere maintenance via recombination (GO:0000722)3.31579181
52somatic diversification of immune receptors via somatic mutation (GO:0002566)3.30323053
53somatic hypermutation of immunoglobulin genes (GO:0016446)3.30323053
54regulation of centriole replication (GO:0046599)3.29920276
55* mRNA stabilization (GO:0048255)3.29169431
56* RNA stabilization (GO:0043489)3.29169431
57formation of translation preinitiation complex (GO:0001731)3.28938771
58alternative mRNA splicing, via spliceosome (GO:0000380)3.28552286
59DNA topological change (GO:0006265)3.25843245
60regulation of translational termination (GO:0006449)3.24749230
61spliceosomal tri-snRNP complex assembly (GO:0000244)3.24636554
62negative regulation of mitotic sister chromatid separation (GO:2000816)3.24277193
63negative regulation of sister chromatid segregation (GO:0033046)3.24277193
64negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.24277193
65negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.24277193
66negative regulation of mitotic sister chromatid segregation (GO:0033048)3.24277193
67chromatin assembly (GO:0031497)3.23109695
68metaphase plate congression (GO:0051310)3.20504272
69purine nucleobase biosynthetic process (GO:0009113)3.19466474
70IMP biosynthetic process (GO:0006188)3.17669310
71chromatin assembly or disassembly (GO:0006333)3.16528854
72peptidyl-arginine omega-N-methylation (GO:0035247)3.16318818
73protein complex localization (GO:0031503)3.15424827
74regulation of DNA endoreduplication (GO:0032875)3.14856640
75kinetochore organization (GO:0051383)3.14375519
76positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.14204305
77positive regulation of mitotic sister chromatid separation (GO:1901970)3.14204305
78positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.14204305
79regulation of translational fidelity (GO:0006450)3.13558915
80negative regulation of DNA repair (GO:0045738)3.13232925
81regulation of nucleobase-containing compound transport (GO:0032239)3.13144650
82histone H2A monoubiquitination (GO:0035518)3.12930215
83protein localization to chromosome (GO:0034502)3.12471108
84RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.11040360
85mRNA splicing, via spliceosome (GO:0000398)3.11040360
86mRNA splice site selection (GO:0006376)3.10819363
87NLS-bearing protein import into nucleus (GO:0006607)3.10370026
88regulation of DNA damage checkpoint (GO:2000001)3.09755830
89DNA replication initiation (GO:0006270)3.07073013
90RNA splicing, via transesterification reactions (GO:0000375)3.06777352
91dosage compensation (GO:0007549)3.06292774
92regulation of chromosome segregation (GO:0051983)3.06090048
93DNA conformation change (GO:0071103)3.05046810
94peptidyl-arginine methylation (GO:0018216)3.04601246
95peptidyl-arginine N-methylation (GO:0035246)3.04601246
96nuclear envelope organization (GO:0006998)3.02862952
97regulation of mitotic sister chromatid separation (GO:0010965)3.02652576
98regulation of mitotic sister chromatid segregation (GO:0033047)3.02652576
99regulation of sister chromatid segregation (GO:0033045)3.02652576
100ATP-dependent chromatin remodeling (GO:0043044)3.00629499
101regulation of posttranscriptional gene silencing (GO:0060147)2.99811765
102regulation of gene silencing by miRNA (GO:0060964)2.99811765
103regulation of gene silencing by RNA (GO:0060966)2.99811765
104chromosome segregation (GO:0007059)2.98874211
105DNA damage response, detection of DNA damage (GO:0042769)2.98853270
106ribosome assembly (GO:0042255)2.98565103
107regulation of centrosome cycle (GO:0046605)2.95530245
108DNA replication-independent nucleosome assembly (GO:0006336)2.95510875
109DNA replication-independent nucleosome organization (GO:0034724)2.95510875
110telomere maintenance via telomere lengthening (GO:0010833)2.93607127
111chromosome condensation (GO:0030261)2.92552896
112mRNA transport (GO:0051028)2.92274774
113translesion synthesis (GO:0019985)2.89166355
114termination of RNA polymerase II transcription (GO:0006369)2.86965160
115attachment of spindle microtubules to kinetochore (GO:0008608)2.86063993
116RNA export from nucleus (GO:0006405)2.85469070
117* regulation of mRNA stability (GO:0043488)2.84535846
118regulation of mitotic metaphase/anaphase transition (GO:0030071)2.83165780
119nucleosome disassembly (GO:0006337)2.82955044
120protein-DNA complex disassembly (GO:0032986)2.82955044
121spindle checkpoint (GO:0031577)2.82895976
122DNA strand elongation involved in DNA replication (GO:0006271)2.82695413
123spindle assembly checkpoint (GO:0071173)2.81946034
124mRNA export from nucleus (GO:0006406)2.81739037
125nucleotide-excision repair, DNA gap filling (GO:0006297)2.81513675
126establishment of chromosome localization (GO:0051303)2.79727984
127regulation of helicase activity (GO:0051095)2.78165262
128negative regulation of chromosome segregation (GO:0051985)2.77746242
129mitotic spindle assembly checkpoint (GO:0007094)2.77155614
130mitotic spindle checkpoint (GO:0071174)2.77017925
131regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.75619032
132nucleobase biosynthetic process (GO:0046112)2.75376826
133establishment of RNA localization (GO:0051236)2.74767190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.41557599
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.31867720
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.88461551
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.51194349
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.29587435
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.21018179
7* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18250000
8MYC_22102868_ChIP-Seq_BL_Human2.98584308
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91450733
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.62236818
11AR_21909140_ChIP-Seq_LNCAP_Human2.62163482
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.60845659
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46166185
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.43883446
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19843355
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15329062
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13806561
18XRN2_22483619_ChIP-Seq_HELA_Human2.02267867
19E2F7_22180533_ChIP-Seq_HELA_Human10.4875426
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.99866584
21CIITA_25753668_ChIP-Seq_RAJI_Human1.98910935
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94592032
23NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90965523
24TP63_19390658_ChIP-ChIP_HaCaT_Human1.84066761
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77158878
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74768382
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67405540
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67135290
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63867345
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62319612
31SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.61199610
32* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60966776
33CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.58241631
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57599066
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57470959
36* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57435605
37* KDM5A_27292631_Chip-Seq_BREAST_Human1.57384971
38* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50889625
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.50839623
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48408138
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46554637
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43058871
43NANOG_21062744_ChIP-ChIP_HESCs_Human1.42815742
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40682816
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40071057
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38215696
47PKCTHETA_26484144_Chip-Seq_BREAST_Human1.37455627
48* CHD1_26751641_Chip-Seq_LNCaP_Human1.37275689
49* TTF2_22483619_ChIP-Seq_HELA_Human1.37085582
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36629211
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35390719
52TCF7_22412390_ChIP-Seq_EML_Mouse1.34542463
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32524700
54* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31000105
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30872330
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29082874
57* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28157682
58VDR_21846776_ChIP-Seq_THP-1_Human1.27443591
59* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26425903
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26010740
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25988079
62FUS_26573619_Chip-Seq_HEK293_Human1.25339935
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24601222
64KDM2B_26808549_Chip-Seq_DND41_Human1.24253192
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24099138
66EWS_26573619_Chip-Seq_HEK293_Human1.23855521
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23384293
68TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22415484
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22064999
70* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21861945
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20934559
72MYC_18940864_ChIP-ChIP_HL60_Human1.19663855
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18138747
74SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18135863
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14250563
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13843112
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.13391433
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12676549
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.12002251
80ETS1_20019798_ChIP-Seq_JURKAT_Human1.11691713
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.10542323
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10432492
83* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07851024
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07749007
85CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07726351
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07300394
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07202650
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06156074
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05724092
90ELK1_19687146_ChIP-ChIP_HELA_Human1.05554162
91WT1_19549856_ChIP-ChIP_CCG9911_Human1.05343764
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05074590
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04477432
94VDR_23849224_ChIP-Seq_CD4+_Human1.04398219
95TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03817669
96GABP_19822575_ChIP-Seq_HepG2_Human1.02692541
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02218078
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01343627
99* FOXP3_21729870_ChIP-Seq_TREG_Human1.00247021
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99723673
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99723673
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99723673
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99027914
104YY1_21170310_ChIP-Seq_MESCs_Mouse0.98995027
105NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98851653
106ZNF263_19887448_ChIP-Seq_K562_Human0.98562954
107TP63_17297297_ChIP-ChIP_HaCaT_Human0.98014027
108* SOX17_20123909_ChIP-Seq_XEN_Mouse0.96230679
109* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95694165
110* CLOCK_20551151_ChIP-Seq_293T_Human0.95329985
111THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94806607
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94794567
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.94658359
114* UTX_26944678_Chip-Seq_JUKART_Human0.94521287
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94344936
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93212889
117* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91726734
118ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91274183
119DCP1A_22483619_ChIP-Seq_HELA_Human0.90605904
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90352207
121* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89906788
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89850836
123* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89787811
124* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89353810
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88137572
126NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87894757
127CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87862584
128* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87208198
129NCOR1_26117541_ChIP-Seq_K562_Human0.87166114
130* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86469551
131IGF1R_20145208_ChIP-Seq_DFB_Human0.85545071
132* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85412195
133SRF_21415370_ChIP-Seq_HL-1_Mouse0.83670510
134POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80814483

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting3.60434857
2MP0003111_abnormal_nucleus_morphology3.47991791
3MP0003693_abnormal_embryo_hatching3.39791061
4MP0010094_abnormal_chromosome_stability3.35836274
5MP0004957_abnormal_blastocyst_morpholog3.21794241
6MP0003077_abnormal_cell_cycle2.92111394
7MP0003705_abnormal_hypodermis_morpholog2.90403479
8MP0010352_gastrointestinal_tract_polyps2.81765497
9MP0000537_abnormal_urethra_morphology2.80859739
10MP0008057_abnormal_DNA_replication2.63391422
11MP0005076_abnormal_cell_differentiation2.58781088
12MP0010234_abnormal_vibrissa_follicle2.55923093
13MP0003121_genomic_imprinting2.50353650
14MP0001730_embryonic_growth_arrest2.39211965
15MP0009053_abnormal_anal_canal2.22470068
16MP0000350_abnormal_cell_proliferation2.15463489
17MP0004197_abnormal_fetal_growth/weight/2.14669884
18MP0002084_abnormal_developmental_patter2.12368442
19MP0010030_abnormal_orbit_morphology2.12227611
20MP0006292_abnormal_olfactory_placode2.11701194
21MP0001672_abnormal_embryogenesis/_devel2.02833275
22MP0005380_embryogenesis_phenotype2.02833275
23MP0009697_abnormal_copulation1.97365990
24MP0002085_abnormal_embryonic_tissue1.94589593
25MP0001697_abnormal_embryo_size1.88729176
26MP0003984_embryonic_growth_retardation1.86451052
27MP0002088_abnormal_embryonic_growth/wei1.85887879
28MP0003567_abnormal_fetal_cardiomyocyte1.80875423
29MP0005187_abnormal_penis_morphology1.79183246
30MP0002086_abnormal_extraembryonic_tissu1.78408089
31MP0003890_abnormal_embryonic-extraembry1.77924322
32MP0008007_abnormal_cellular_replicative1.76345487
33MP0010307_abnormal_tumor_latency1.75817023
34MP0005394_taste/olfaction_phenotype1.62252359
35MP0005499_abnormal_olfactory_system1.62252359
36* MP0002080_prenatal_lethality1.62023249
37MP0003119_abnormal_digestive_system1.59789698
38MP0009672_abnormal_birth_weight1.55409063
39MP0000428_abnormal_craniofacial_morphol1.54968760
40* MP0008932_abnormal_embryonic_tissue1.54927054
41MP0000569_abnormal_digit_pigmentation1.53559365
42MP0003122_maternal_imprinting1.51749301
43MP0001293_anophthalmia1.50806054
44MP0003221_abnormal_cardiomyocyte_apopto1.50046072
45MP0009703_decreased_birth_body1.48572016
46MP0008058_abnormal_DNA_repair1.48384697
47MP0008789_abnormal_olfactory_epithelium1.48237978
48MP0003937_abnormal_limbs/digits/tail_de1.47956609
49MP0001188_hyperpigmentation1.47330125
50MP0003718_maternal_effect1.45796890
51MP0000733_abnormal_muscle_development1.44050343
52MP0004808_abnormal_hematopoietic_stem1.43012717
53MP0003787_abnormal_imprinting1.38843709
54MP0002396_abnormal_hematopoietic_system1.36391868
55MP0003935_abnormal_craniofacial_develop1.32105755
56MP0003115_abnormal_respiratory_system1.31965730
57MP0001849_ear_inflammation1.31889490
58MP0003385_abnormal_body_wall1.30313741
59MP0000049_abnormal_middle_ear1.29790239
60MP0006054_spinal_hemorrhage1.25116961
61MP0004233_abnormal_muscle_weight1.21534395
62MP0008877_abnormal_DNA_methylation1.19018413
63MP0006035_abnormal_mitochondrial_morpho1.17689359
64MP0001529_abnormal_vocalization1.14883322
65MP0003283_abnormal_digestive_organ1.14661743
66MP0002653_abnormal_ependyma_morphology1.14586690
67MP0002092_abnormal_eye_morphology1.13005075
68MP0003861_abnormal_nervous_system1.12977779
69MP0009278_abnormal_bone_marrow1.12726640
70MP0000566_synostosis1.12722028
71MP0002111_abnormal_tail_morphology1.10573710
72MP0002697_abnormal_eye_size1.09484961
73MP0010678_abnormal_skin_adnexa1.09072294
74MP0000778_abnormal_nervous_system1.07931525
75MP0003755_abnormal_palate_morphology1.05713357
76MP0000432_abnormal_head_morphology1.04954405
77MP0002925_abnormal_cardiovascular_devel1.04702691
78MP0002932_abnormal_joint_morphology1.04650366
79MP0001299_abnormal_eye_distance/1.04609477
80MP0005623_abnormal_meninges_morphology1.03314006
81MP0003315_abnormal_perineum_morphology1.01370777
82MP0003566_abnormal_cell_adhesion0.97086374
83MP0003941_abnormal_skin_development0.96647090
84MP0003942_abnormal_urinary_system0.95736053
85MP0003880_abnormal_central_pattern0.95181086
86MP0002877_abnormal_melanocyte_morpholog0.94260096
87MP0000313_abnormal_cell_death0.92444963
88MP0001286_abnormal_eye_development0.92005898
89MP0002009_preneoplasia0.91686343
90MP0000703_abnormal_thymus_morphology0.90890705
91MP0001915_intracranial_hemorrhage0.89951012
92MP0006072_abnormal_retinal_apoptosis0.88874843
93MP0000534_abnormal_ureter_morphology0.88820433
94MP0008770_decreased_survivor_rate0.87175012
95MP0002114_abnormal_axial_skeleton0.85376401
96MP0001177_atelectasis0.84093711
97MP0002751_abnormal_autonomic_nervous0.83274947
98MP0000490_abnormal_crypts_of0.83039748
99MP0003786_premature_aging0.82900566
100MP0002081_perinatal_lethality0.82561738
101MP0001346_abnormal_lacrimal_gland0.82000430
102MP0004264_abnormal_extraembryonic_tissu0.81110401
103MP0002234_abnormal_pharynx_morphology0.80984485
104MP0004185_abnormal_adipocyte_glucose0.80744134
105MP0002102_abnormal_ear_morphology0.79928762
106MP0002116_abnormal_craniofacial_bone0.78837849
107MP0002019_abnormal_tumor_incidence0.78628539
108MP0000751_myopathy0.78440601
109MP0002282_abnormal_trachea_morphology0.78439534
110MP0000266_abnormal_heart_morphology0.78403967
111MP0000516_abnormal_urinary_system0.77985100
112MP0005367_renal/urinary_system_phenotyp0.77985100
113MP0008995_early_reproductive_senescence0.77879810
114MP0004133_heterotaxia0.75929831
115MP0000631_abnormal_neuroendocrine_gland0.75836758
116MP0000383_abnormal_hair_follicle0.75788208
117MP0002938_white_spotting0.75524203
118MP0000358_abnormal_cell_content/0.74735722
119MP0002152_abnormal_brain_morphology0.74677256
120MP0002233_abnormal_nose_morphology0.74544336
121MP0001929_abnormal_gametogenesis0.74431768
122MP0001784_abnormal_fluid_regulation0.74287168
123MP0004859_abnormal_synaptic_plasticity0.73973806
124MP0004147_increased_porphyrin_level0.71474159
125MP0002210_abnormal_sex_determination0.70946493
126MP0005384_cellular_phenotype0.70933899
127MP0005248_abnormal_Harderian_gland0.69863364
128MP0000653_abnormal_sex_gland0.69761429
129MP0004811_abnormal_neuron_physiology0.66754741
130MP0010630_abnormal_cardiac_muscle0.66349906
131MP0001145_abnormal_male_reproductive0.65634639
132MP0000377_abnormal_hair_follicle0.64379490
133MP0002249_abnormal_larynx_morphology0.64208543
134MP0003938_abnormal_ear_development0.62860795
135MP0002109_abnormal_limb_morphology0.62668053
136MP0009250_abnormal_appendicular_skeleto0.62530990

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)4.37557050
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.89282183
3Short 4th metacarpal (HP:0010044)3.89282183
4Chromsome breakage (HP:0040012)3.76204141
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.69294641
6Volvulus (HP:0002580)3.38353171
7Colon cancer (HP:0003003)3.27952318
8Increased nuchal translucency (HP:0010880)3.26620716
9Hyperacusis (HP:0010780)3.11344534
10Renal duplication (HP:0000075)3.08433099
11Ependymoma (HP:0002888)3.08157573
12Abnormality of the 4th metacarpal (HP:0010012)3.07625000
13Medulloblastoma (HP:0002885)2.90374767
14Progressive external ophthalmoplegia (HP:0000590)2.83881524
15Nephroblastoma (Wilms tumor) (HP:0002667)2.78575332
16Abnormal lung lobation (HP:0002101)2.75185754
17Meckel diverticulum (HP:0002245)2.74956410
18Birth length less than 3rd percentile (HP:0003561)2.67526924
19Proximal placement of thumb (HP:0009623)2.65631796
20Embryonal renal neoplasm (HP:0011794)2.65144137
21Deviation of the thumb (HP:0009603)2.59045634
22Abnormality of the astrocytes (HP:0100707)2.58644424
23Astrocytoma (HP:0009592)2.58644424
24Selective tooth agenesis (HP:0001592)2.58105451
25Abnormality of the ileum (HP:0001549)2.55855915
26Rectal prolapse (HP:0002035)2.52265792
27Renovascular hypertension (HP:0100817)2.51281799
28Abnormality of chromosome stability (HP:0003220)2.47689538
29Shallow orbits (HP:0000586)2.46141581
30Abnormality of the labia minora (HP:0012880)2.38492922
31Elfin facies (HP:0004428)2.37297129
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.36704880
33Abnormality of glycolysis (HP:0004366)2.30966739
34Gastrointestinal carcinoma (HP:0002672)2.30557532
35Malignant gastrointestinal tract tumors (HP:0006749)2.30557532
36Abnormality of the preputium (HP:0100587)2.29426296
37Increased serum pyruvate (HP:0003542)2.29103697
38Supernumerary ribs (HP:0005815)2.27643428
39Progressive muscle weakness (HP:0003323)2.26570956
40Hepatoblastoma (HP:0002884)2.26253308
41Abnormality of the fingertips (HP:0001211)2.26023419
42Long eyelashes (HP:0000527)2.25993987
43Subacute progressive viral hepatitis (HP:0006572)2.25896072
44Abnormal number of incisors (HP:0011064)2.25163333
45Pseudobulbar signs (HP:0002200)2.24920938
46Neoplasm of striated muscle (HP:0009728)2.24400061
47Urethral obstruction (HP:0000796)2.24125201
48Rhabdomyosarcoma (HP:0002859)2.23664108
49Overriding aorta (HP:0002623)2.22352871
50Pelvic girdle muscle weakness (HP:0003749)2.22317789
51Broad thumb (HP:0011304)2.22203916
52Obsessive-compulsive behavior (HP:0000722)2.19069931
53Absent radius (HP:0003974)2.18727893
54Glioma (HP:0009733)2.18296778
55Biliary tract neoplasm (HP:0100574)2.17777216
56Duodenal stenosis (HP:0100867)2.17736138
57Small intestinal stenosis (HP:0012848)2.17736138
58Pointed chin (HP:0000307)2.16884627
59Neoplasm of the oral cavity (HP:0100649)2.15934498
60Microvesicular hepatic steatosis (HP:0001414)2.12547541
61Gonadotropin excess (HP:0000837)2.10944654
62Atresia of the external auditory canal (HP:0000413)2.09592502
63Abnormality of the diencephalon (HP:0010662)2.08203692
64Basal cell carcinoma (HP:0002671)2.08106368
65Oligodactyly (HP:0012165)2.06127478
66Trigonocephaly (HP:0000243)2.05641013
67Macroorchidism (HP:0000053)2.05441979
68Aplasia involving forearm bones (HP:0009822)2.05105428
69Absent forearm bone (HP:0003953)2.05105428
70Supernumerary bones of the axial skeleton (HP:0009144)2.04969137
71Broad palm (HP:0001169)2.04885267
72Ankyloglossia (HP:0010296)2.04775914
73Spastic diplegia (HP:0001264)2.03896170
74Heterotopia (HP:0002282)2.03494586
75Skull defect (HP:0001362)2.03112902
76Shoulder girdle muscle weakness (HP:0003547)2.02241761
77Aplasia/Hypoplasia of the sternum (HP:0006714)2.01056287
78Skin tags (HP:0010609)1.99399004
79Facial hemangioma (HP:0000329)1.97088320
80Esophageal atresia (HP:0002032)1.96724923
81Insomnia (HP:0100785)1.96567825
82Sandal gap (HP:0001852)1.95067681
83Myelodysplasia (HP:0002863)1.94932340
84Vertebral arch anomaly (HP:0008438)1.94708783
85Abnormality of the duodenum (HP:0002246)1.94242345
86Cutis marmorata (HP:0000965)1.93554794
87Exercise-induced muscle cramps (HP:0003710)1.93536496
88Bowel diverticulosis (HP:0005222)1.91689703
89Sacral dimple (HP:0000960)1.91155216
90Broad phalanges of the hand (HP:0009768)1.90355567
91Embryonal neoplasm (HP:0002898)1.88988892
92Prominent nose (HP:0000448)1.88959476
93Patellar aplasia (HP:0006443)1.87898173
94Neoplasm of the colon (HP:0100273)1.87694909
95Neuroblastic tumors (HP:0004376)1.86946751
96Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.86946751
97Neuroblastoma (HP:0003006)1.86946751
98Primitive neuroectodermal tumor (HP:0030065)1.86946751
99Ectopic kidney (HP:0000086)1.86503030
100Missing ribs (HP:0000921)1.86477571
101High pitched voice (HP:0001620)1.85973557
102Termporal pattern (HP:0011008)1.85321843
103Insidious onset (HP:0003587)1.85321843
104Increased density of long bones (HP:0006392)1.85078670
105Aplasia/Hypoplasia of the patella (HP:0006498)1.84497613
106Abnormality of cochlea (HP:0000375)1.84229021
107Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.83221772
108Generalized hypotonia (HP:0001290)1.81343508
109Abnormality of the carotid arteries (HP:0005344)1.81239741
110Triphalangeal thumb (HP:0001199)1.79505321
111Fibrous tissue neoplasm (HP:0012316)1.79154244
112Horseshoe kidney (HP:0000085)1.78961212
113Intestinal polyp (HP:0005266)1.77787123
114Abnormality of the musculature of the pelvis (HP:0001469)1.77536158
115Abnormality of the hip-girdle musculature (HP:0001445)1.77536158
116Sloping forehead (HP:0000340)1.77425887
117Broad finger (HP:0001500)1.76956819
118Deep philtrum (HP:0002002)1.76178890
119Enlarged penis (HP:0000040)1.76124262
120Abnormality of oral frenula (HP:0000190)1.76124258
121Abnormality of the lower motor neuron (HP:0002366)1.75200275
122Overlapping toe (HP:0001845)1.75070221
123Postnatal microcephaly (HP:0005484)1.74635944
124Abnormality of chromosome segregation (HP:0002916)1.72951821
125Back pain (HP:0003418)1.72655135
126Preauricular skin tag (HP:0000384)1.72291002
127Low anterior hairline (HP:0000294)1.71676247
128Short phalanx of the thumb (HP:0009660)1.71530523
129Fibroma (HP:0010614)1.70853532
130Intestinal polyposis (HP:0200008)1.70682918
131High anterior hairline (HP:0009890)1.70162711
132Narrow palate (HP:0000189)1.69925510
133Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69847531
134Uterine neoplasm (HP:0010784)1.69107378
135Deviation of the hallux (HP:0010051)1.68916301
136Flat cornea (HP:0007720)1.67981328
137Hypoplastic labia majora (HP:0000059)1.67408602
138Calcaneovalgus deformity (HP:0001848)1.66353515
139Multiple enchondromatosis (HP:0005701)1.66237617
140Uterine leiomyosarcoma (HP:0002891)1.65835515
141Leiomyosarcoma (HP:0100243)1.65835515
142Anal stenosis (HP:0002025)1.65515543
143Hallux valgus (HP:0001822)1.65510956
144Truncal obesity (HP:0001956)1.64306982
145Duplication of thumb phalanx (HP:0009942)1.63344398
146Supernumerary spleens (HP:0009799)1.62999168
147Abnormality of the septum pellucidum (HP:0007375)1.62113142
148Morphological abnormality of the inner ear (HP:0011390)1.62067110
149Spina bifida occulta (HP:0003298)1.61144295
150Cafe-au-lait spot (HP:0000957)1.59873629
151Shawl scrotum (HP:0000049)1.59869710
152Septo-optic dysplasia (HP:0100842)1.58085866
153Abnormality of the calcaneus (HP:0008364)1.57165357
154Coarctation of aorta (HP:0001680)1.56920379
155Choanal atresia (HP:0000453)1.56333541
156Hemivertebrae (HP:0002937)1.54220121
157Papillary thyroid carcinoma (HP:0002895)1.54006997
158Gout (HP:0001997)1.53660529
159Deformed tarsal bones (HP:0008119)1.52349446
160Agnosia (HP:0010524)1.50340549
161Nervous tissue neoplasm (HP:0030060)1.49482396
162Neuroectodermal neoplasm (HP:0030061)1.49482396
163Neuroepithelial neoplasm (HP:0030063)1.49482396
164Neoplasm of the small intestine (HP:0100833)1.48791279
165Abnormality of the metopic suture (HP:0005556)1.46420537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.18398799
2CDK123.27801932
3NEK23.23783129
4EEF2K3.05919834
5PKN22.84812582
6MAP3K102.76637958
7NEK12.57088375
8TRIB32.45920484
9WEE12.45294120
10MKNK12.21429326
11SRPK12.13793755
12LATS12.13071490
13TRIM282.07001658
14TTK2.06924234
15ALK2.02733554
16PBK2.00087728
17TSSK61.99374531
18BRD41.97876974
19BCR1.90068117
20CDK61.82856037
21TNIK1.73679957
22RPS6KB21.73013752
23MKNK21.71984188
24CDK41.71806879
25PNCK1.66005384
26PASK1.61215791
27BUB11.60193142
28PTK61.51933197
29MAP4K21.47585570
30ATR1.43458158
31CHEK11.39998482
32VRK21.39012276
33SIK31.38120261
34PLK31.37731770
35MAP3K81.32727270
36FGFR11.29921548
37PLK11.29718762
38PAK41.28614443
39TAF11.28170646
40MTOR1.25971786
41AURKB1.25276233
42PDGFRA1.23158128
43SIK21.21968099
44STK31.18689101
45RPS6KA41.15476674
46EIF2AK31.13167710
47SCYL21.09479935
48ERBB31.08468974
49CDK71.08286505
50ACVR1B1.08256244
51CDK21.06019625
52CHEK21.05345222
53TTN1.04916731
54ATM1.02733742
55ICK1.02106508
56STK101.01691513
57LRRK21.00043732
58MELK0.99096054
59TGFBR10.97082915
60UHMK10.96925386
61RIPK10.94246761
62CCNB10.92197323
63LATS20.88504754
64CDK30.87766419
65TYRO30.87249847
66PLK40.85658342
67BRSK20.85401370
68CDK10.82563556
69CSNK1E0.81985135
70KSR10.80226204
71CLK10.78501811
72PAK20.78272061
73EIF2AK20.74094465
74STK38L0.74040524
75CDK180.71927907
76MAP2K70.71353520
77CAMK1G0.71223473
78MAP3K40.71161839
79NME10.70720743
80CDK140.70635721
81DYRK30.69896268
82BRSK10.69594970
83CSNK1D0.69468057
84PRKDC0.68882103
85CSNK1G30.67025139
86CDK80.66643201
87CSNK1A1L0.66595658
88CSNK1G20.65558323
89CDK11A0.64973059
90CDK150.64886232
91MINK10.64416098
92CSNK1G10.62570783
93FGFR20.61365210
94STK40.60180289
95ZAK0.59496651
96EPHA20.58515073
97SIK10.58499646
98VRK10.58343316
99ERBB20.57795020
100EIF2AK10.57177016
101DDR20.57067370
102PDGFRB0.56965957
103EPHA40.56474031
104AKT20.54412044
105ERBB40.53418623
106MAPK140.52913946
107SMG10.52322907
108CAMK1D0.51271835
109BMX0.50951211
110WNK30.50031856
111MST40.49791668
112YES10.46720570
113CDK90.46642752
114KSR20.46312114
115DYRK20.44842925
116GSK3B0.43753394
117* CSNK2A10.43360334
118CSNK2A20.42944340
119TESK20.42706655
120EPHB20.39487561
121AURKA0.38438439
122MAPK100.37796516
123FGFR30.37049141
124AKT10.36904269
125RET0.36107601
126RPS6KB10.35842310
127PDK20.35050757
128CDC42BPA0.34605471
129PLK20.34035984
130TAOK10.33627725
131TLK10.33032572
132MAPK10.32562169
133ILK0.32476579
134MAPK80.32112073
135MAP3K70.31698361
136MAPK90.30966185
137STK240.30570692
138DMPK0.30507392
139PIM10.30394328
140PRKD30.30024344
141CDK190.29420198
142PTK20.29236023

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030403.24500616
2RNA transport_Homo sapiens_hsa030133.11795298
3DNA replication_Homo sapiens_hsa030303.11330209
4Cell cycle_Homo sapiens_hsa041102.79522473
5Mismatch repair_Homo sapiens_hsa034302.75707546
6mRNA surveillance pathway_Homo sapiens_hsa030152.73124216
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54825633
8One carbon pool by folate_Homo sapiens_hsa006702.26518517
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.09494976
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98208336
11Proteasome_Homo sapiens_hsa030501.95629146
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.81840881
13Basal cell carcinoma_Homo sapiens_hsa052171.77317822
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75127234
15Oocyte meiosis_Homo sapiens_hsa041141.68879363
16Base excision repair_Homo sapiens_hsa034101.68805589
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.67429990
18MicroRNAs in cancer_Homo sapiens_hsa052061.65920293
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65595530
20Nucleotide excision repair_Homo sapiens_hsa034201.63177110
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61984548
22Hippo signaling pathway_Homo sapiens_hsa043901.56561126
23Chronic myeloid leukemia_Homo sapiens_hsa052201.52912520
24mTOR signaling pathway_Homo sapiens_hsa041501.47458939
25RNA degradation_Homo sapiens_hsa030181.47141531
26Colorectal cancer_Homo sapiens_hsa052101.42331338
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41707778
28Lysine degradation_Homo sapiens_hsa003101.41572468
29Pyruvate metabolism_Homo sapiens_hsa006201.38366295
30Homologous recombination_Homo sapiens_hsa034401.34512269
31Small cell lung cancer_Homo sapiens_hsa052221.31367488
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31141796
33Carbon metabolism_Homo sapiens_hsa012001.30505056
34HTLV-I infection_Homo sapiens_hsa051661.29083394
35Hedgehog signaling pathway_Homo sapiens_hsa043401.28787025
36Protein export_Homo sapiens_hsa030601.27947866
37Adherens junction_Homo sapiens_hsa045201.27337525
38Fanconi anemia pathway_Homo sapiens_hsa034601.25916153
39Endometrial cancer_Homo sapiens_hsa052131.25907388
40Non-homologous end-joining_Homo sapiens_hsa034501.25661886
41Propanoate metabolism_Homo sapiens_hsa006401.24107123
42p53 signaling pathway_Homo sapiens_hsa041151.23623780
43Proteoglycans in cancer_Homo sapiens_hsa052051.21682176
44Viral carcinogenesis_Homo sapiens_hsa052031.19740696
45Non-small cell lung cancer_Homo sapiens_hsa052231.17245413
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16957120
47Steroid biosynthesis_Homo sapiens_hsa001001.11753320
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09769907
49Thyroid cancer_Homo sapiens_hsa052161.08829502
50TGF-beta signaling pathway_Homo sapiens_hsa043501.07679968
51Notch signaling pathway_Homo sapiens_hsa043301.05810158
52Wnt signaling pathway_Homo sapiens_hsa043101.05541292
53Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03078345
54Purine metabolism_Homo sapiens_hsa002301.02254860
55Central carbon metabolism in cancer_Homo sapiens_hsa052301.02050343
56Glioma_Homo sapiens_hsa052140.96700348
57Ribosome_Homo sapiens_hsa030100.94882199
58Bladder cancer_Homo sapiens_hsa052190.93253940
59Prostate cancer_Homo sapiens_hsa052150.93196831
60Epstein-Barr virus infection_Homo sapiens_hsa051690.93159048
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91424142
62Antigen processing and presentation_Homo sapiens_hsa046120.90861750
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90124665
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89963425
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87795656
66Systemic lupus erythematosus_Homo sapiens_hsa053220.87187011
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.85657508
68Pancreatic cancer_Homo sapiens_hsa052120.83372722
69Renal cell carcinoma_Homo sapiens_hsa052110.82511074
70Pathways in cancer_Homo sapiens_hsa052000.81823744
71Tight junction_Homo sapiens_hsa045300.80582600
72Herpes simplex infection_Homo sapiens_hsa051680.79253661
73Dorso-ventral axis formation_Homo sapiens_hsa043200.77206057
74FoxO signaling pathway_Homo sapiens_hsa040680.76118931
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75904636
76Focal adhesion_Homo sapiens_hsa045100.75485902
77Fatty acid elongation_Homo sapiens_hsa000620.74534499
78Estrogen signaling pathway_Homo sapiens_hsa049150.73966349
79Viral myocarditis_Homo sapiens_hsa054160.73184728
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71932813
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71788993
82Long-term potentiation_Homo sapiens_hsa047200.67070619
83Basal transcription factors_Homo sapiens_hsa030220.66644103
84T cell receptor signaling pathway_Homo sapiens_hsa046600.65086186
85Acute myeloid leukemia_Homo sapiens_hsa052210.64951102
86Alcoholism_Homo sapiens_hsa050340.64469550
87VEGF signaling pathway_Homo sapiens_hsa043700.64360650
88Melanogenesis_Homo sapiens_hsa049160.62811196
89Hepatitis B_Homo sapiens_hsa051610.62075122
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61181794
91ErbB signaling pathway_Homo sapiens_hsa040120.61119678
92RNA polymerase_Homo sapiens_hsa030200.59918389
93Pentose phosphate pathway_Homo sapiens_hsa000300.59416095
94HIF-1 signaling pathway_Homo sapiens_hsa040660.58808345
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58282933
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56249746
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55822226
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55447610
99Pyrimidine metabolism_Homo sapiens_hsa002400.55086995
100AMPK signaling pathway_Homo sapiens_hsa041520.54685163
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54624532
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.54535670
103Melanoma_Homo sapiens_hsa052180.54418624
104Biosynthesis of amino acids_Homo sapiens_hsa012300.53966582
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.53960279
106B cell receptor signaling pathway_Homo sapiens_hsa046620.50300914
107Insulin signaling pathway_Homo sapiens_hsa049100.50260589
108Arginine and proline metabolism_Homo sapiens_hsa003300.48838971
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48434863
110Rap1 signaling pathway_Homo sapiens_hsa040150.47748724
111Fatty acid metabolism_Homo sapiens_hsa012120.46681525
112Selenocompound metabolism_Homo sapiens_hsa004500.46442343
113Glucagon signaling pathway_Homo sapiens_hsa049220.45625851
114Gap junction_Homo sapiens_hsa045400.45182088
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44353174
116Insulin resistance_Homo sapiens_hsa049310.42030147
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42018235
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41906432
119Platelet activation_Homo sapiens_hsa046110.41682944
120ECM-receptor interaction_Homo sapiens_hsa045120.41618465
121Vitamin B6 metabolism_Homo sapiens_hsa007500.41374033
122Type II diabetes mellitus_Homo sapiens_hsa049300.40452219
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40248050
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39473250
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38548314
126Axon guidance_Homo sapiens_hsa043600.38436890
127Circadian rhythm_Homo sapiens_hsa047100.35941603
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34354282
129Nicotine addiction_Homo sapiens_hsa050330.27312697
130Huntingtons disease_Homo sapiens_hsa050160.27184316
131Fructose and mannose metabolism_Homo sapiens_hsa000510.26273131
132Folate biosynthesis_Homo sapiens_hsa007900.25203866
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24550657
134Metabolic pathways_Homo sapiens_hsa011000.21460305
135Butanoate metabolism_Homo sapiens_hsa006500.20928974
136Glutathione metabolism_Homo sapiens_hsa004800.15385779
137Arginine biosynthesis_Homo sapiens_hsa002200.12128769
138N-Glycan biosynthesis_Homo sapiens_hsa005100.11817767
139beta-Alanine metabolism_Homo sapiens_hsa004100.11580493
140Olfactory transduction_Homo sapiens_hsa047400.11126276
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10465832
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.10284471

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