ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pharyngeal system development (GO:0060037)	7.62137768
2	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	6.67925073
3	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	6.67925073
4	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	6.19323958
5	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	6.19323958
6	spinal cord association neuron differentiation (GO:0021527)	6.00807154
7	serotonin metabolic process (GO:0042428)	5.77566605
8	phosphatidylinositol acyl-chain remodeling (GO:0036149)	5.62013890
9	cell proliferation in forebrain (GO:0021846)	5.53346651
10	histone H4-K12 acetylation (GO:0043983)	5.43485183
11	cerebellar Purkinje cell differentiation (GO:0021702)	5.35389265
12	opioid receptor signaling pathway (GO:0038003)	5.11680163
13	kynurenine metabolic process (GO:0070189)	5.05820270
14	positive regulation of mRNA catabolic process (GO:0061014)	5.02643414
15	interkinetic nuclear migration (GO:0022027)	4.95576422
16	positive regulation of mRNA 3-end processing (GO:0031442)	4.89288965
17	urinary tract smooth muscle contraction (GO:0014848)	4.87938209
18	primary amino compound metabolic process (GO:1901160)	4.81288924
19	indole-containing compound catabolic process (GO:0042436)	4.79759393
20	indolalkylamine catabolic process (GO:0046218)	4.79759393
21	tryptophan catabolic process (GO:0006569)	4.79759393
22	phosphatidylserine acyl-chain remodeling (GO:0036150)	4.73888221
23	indole-containing compound metabolic process (GO:0042430)	4.67037087
24	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.59853767
25	peristalsis (GO:0030432)	4.52146756
26	multicellular organismal movement (GO:0050879)	4.43984855
27	musculoskeletal movement (GO:0050881)	4.43984855
28	skeletal muscle adaptation (GO:0043501)	4.25277121
29	regulation of rhodopsin mediated signaling pathway (GO:0022400)	4.19594072
30	cytoplasmic mRNA processing body assembly (GO:0033962)	4.18899073
31	forebrain neuron differentiation (GO:0021879)	4.16890076
32	regulation of mRNA catabolic process (GO:0061013)	4.14583542
33	striated muscle atrophy (GO:0014891)	4.11632918
34	indolalkylamine metabolic process (GO:0006586)	4.08889178
35	regulation of mRNA 3-end processing (GO:0031440)	4.02151413
36	negative regulation of sodium ion transport (GO:0010766)	3.98716225
37	response to gravity (GO:0009629)	3.96376633
38	positive regulation of mRNA processing (GO:0050685)	3.93805203
39	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	3.89198554
40	tryptophan metabolic process (GO:0006568)	3.87403499
41	neuronal action potential (GO:0019228)	3.82751337
42	rhodopsin mediated signaling pathway (GO:0016056)	3.81950631
43	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.77489232
44	megakaryocyte development (GO:0035855)	3.77349682
45	multicellular organism reproduction (GO:0032504)	3.69575791
46	regulation of skeletal muscle contraction (GO:0014819)	3.67201066
47	negative regulation of systemic arterial blood pressure (GO:0003085)	3.58420045
48	embryonic hemopoiesis (GO:0035162)	3.54236067
49	protein K48-linked ubiquitination (GO:0070936)	3.53240638
50	kidney morphogenesis (GO:0060993)	3.52206154
51	phospholipid catabolic process (GO:0009395)	3.50528565
52	locomotory exploration behavior (GO:0035641)	3.45070614
53	embryonic heart tube development (GO:0035050)	3.44392814
54	positive regulation of mRNA metabolic process (GO:1903313)	3.40622688
55	muscle atrophy (GO:0014889)	3.29558514
56	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.17211413
57	regulation of collateral sprouting (GO:0048670)	3.16495966
58	membrane depolarization during action potential (GO:0086010)	3.14928047
59	calcium ion import (GO:0070509)	3.13854568
60	exploration behavior (GO:0035640)	3.08550914
61	GMP metabolic process (GO:0046037)	3.07174565
62	phosphatidylcholine acyl-chain remodeling (GO:0036151)	3.04375299
63	behavioral response to ethanol (GO:0048149)	3.03524392
64	cell differentiation in hindbrain (GO:0021533)	3.01014675
65	heart trabecula morphogenesis (GO:0061384)	3.00899233
66	regulation of posttranscriptional gene silencing (GO:0060147)	2.99136256
67	regulation of gene silencing by miRNA (GO:0060964)	2.99136256
68	regulation of gene silencing by RNA (GO:0060966)	2.99136256
69	heparin biosynthetic process (GO:0030210)	2.95763293
70	heparin metabolic process (GO:0030202)	2.95763293
71	regulation of meiosis I (GO:0060631)	2.93849884
72	dopamine biosynthetic process (GO:0042416)	2.92731440
73	response to muscle activity (GO:0014850)	2.92246288
74	mitochondrial genome maintenance (GO:0000002)	2.90479624
75	negative regulation of protein localization to cell surface (GO:2000009)	2.89730325
76	histone H4-K5 acetylation (GO:0043981)	2.89521732
77	histone H4-K8 acetylation (GO:0043982)	2.89521732
78	cell differentiation in spinal cord (GO:0021515)	2.87253025
79	DNA replication checkpoint (GO:0000076)	2.86375694
80	seminiferous tubule development (GO:0072520)	2.85644775
81	thyroid hormone metabolic process (GO:0042403)	2.80242333
82	response to folic acid (GO:0051593)	2.79745775
83	organ formation (GO:0048645)	2.74675909
84	positive regulation of glomerulus development (GO:0090193)	2.73957402
85	endoderm formation (GO:0001706)	2.73089475
86	pantothenate metabolic process (GO:0015939)	2.69541569
87	amine catabolic process (GO:0009310)	2.68823348
88	cellular biogenic amine catabolic process (GO:0042402)	2.68823348
89	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.68587336
90	protein K6-linked ubiquitination (GO:0085020)	2.60250648
91	muscle filament sliding (GO:0030049)	2.59579078
92	actin-myosin filament sliding (GO:0033275)	2.59579078
93	one-carbon compound transport (GO:0019755)	2.58417737
94	cellular sodium ion homeostasis (GO:0006883)	2.57324884
95	eye photoreceptor cell development (GO:0042462)	2.57236408
96	protein-cofactor linkage (GO:0018065)	2.55483880
97	regulation of interleukin-8 secretion (GO:2000482)	2.55022423
98	negative regulation of keratinocyte proliferation (GO:0010839)	2.53086986
99	phosphatidylserine metabolic process (GO:0006658)	2.53021711
100	negative regulation of muscle hypertrophy (GO:0014741)	2.52396345

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.60827472
2	VDR_22108803_ChIP-Seq_LS180_Human	3.48863631
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.96644324
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.68741137
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.67146331
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.63359081
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.56798168
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.48051321
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.47542155
10	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	2.43278558
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.28504615
12	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.19500491
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.16600977
14	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.12311329
15	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.12311329
16	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.09391228
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.99840938
18	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.96769054
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.95589843
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.91912630
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.89540571
22	FUS_26573619_Chip-Seq_HEK293_Human	1.85989358
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.81620691
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.79850617
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.77950041
26	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.71693840
27	EWS_26573619_Chip-Seq_HEK293_Human	1.70713018
28	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.70365649
29	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.68189479
30	P300_19829295_ChIP-Seq_ESCs_Human	1.65208028
31	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.63015765
32	STAT3_23295773_ChIP-Seq_U87_Human	1.62383514
33	AR_21572438_ChIP-Seq_LNCaP_Human	1.61045354
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60110984
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.56837624
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.54846874
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.52573574
38	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.49918476
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.49402495
40	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48638027
41	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48130364
42	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.44797542
43	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.43462333
44	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.42888998
45	RXR_22108803_ChIP-Seq_LS180_Human	1.42706857
46	REST_21632747_ChIP-Seq_MESCs_Mouse	1.42521482
47	RNF2_27304074_Chip-Seq_NSC_Mouse	1.41115441
48	AR_25329375_ChIP-Seq_VCAP_Human	1.40930738
49	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.40854950
50	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.39301323
51	TCF4_23295773_ChIP-Seq_U87_Human	1.34790308
52	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.34489730
53	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.30107711
54	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.28046346
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27168312
56	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.25274541
57	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.23876187
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23585237
59	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.23060007
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21035955
61	AR_20517297_ChIP-Seq_VCAP_Human	1.19018168
62	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.18593834
63	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.17202274
64	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.16250289
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.15762829
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.15762829
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13974675
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12028599
69	GATA3_26560356_Chip-Seq_TH2_Human	1.11925862
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11355384
71	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10318470
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09071940
73	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.08883193
74	CBP_20019798_ChIP-Seq_JUKART_Human	1.08883193
75	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08693643
76	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.08597246
77	KDM2B_26808549_Chip-Seq_REH_Human	1.08179092
78	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06751455
79	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06540041
80	DROSHA_22980978_ChIP-Seq_HELA_Human	1.05361446
81	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.05183414
82	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.03224481
83	IRF1_19129219_ChIP-ChIP_H3396_Human	1.02913091
84	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01588949
85	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01298813
86	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.01123174
87	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.01041644
88	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.00899243
89	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.00142460
90	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.00137157
91	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.99910554
92	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.99910554
93	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.99234277
94	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.98450596
95	NCOR_22424771_ChIP-Seq_293T_Human	0.98165983
96	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.97056088
97	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.96730747
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96682707
99	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.95445619
100	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.94303715

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002876_abnormal_thyroid_physiology	4.20877825
2	MP0004145_abnormal_muscle_electrophysio	3.51143744
3	MP0003950_abnormal_plasma_membrane	3.34883008
4	MP0003646_muscle_fatigue	3.30481515
5	MP0004885_abnormal_endolymph	3.27628927
6	MP0005646_abnormal_pituitary_gland	2.94535592
7	MP0000569_abnormal_digit_pigmentation	2.75529655
8	MP0002138_abnormal_hepatobiliary_system	2.40688125
9	MP0006276_abnormal_autonomic_nervous	2.23051510
10	MP0001501_abnormal_sleep_pattern	2.08339771
11	MP0000230_abnormal_systemic_arterial	2.07708043
12	MP0001968_abnormal_touch/_nociception	2.00961485
13	MP0005503_abnormal_tendon_morphology	1.98169393
14	MP0002837_dystrophic_cardiac_calcinosis	1.98145750
15	MP0005671_abnormal_response_to	1.97188826
16	MP0006054_spinal_hemorrhage	1.86949096
17	MP0003880_abnormal_central_pattern	1.85190381
18	MP0009333_abnormal_splenocyte_physiolog	1.83786534
19	MP0004142_abnormal_muscle_tone	1.79062004
20	MP0005551_abnormal_eye_electrophysiolog	1.78339714
21	MP0001765_abnormal_ion_homeostasis	1.77773078
22	MP0004270_analgesia	1.65410385
23	MP0009046_muscle_twitch	1.65385971
24	MP0009745_abnormal_behavioral_response	1.64800120
25	MP0001485_abnormal_pinna_reflex	1.63458793
26	MP0002734_abnormal_mechanical_nocicepti	1.61983857
27	MP0003137_abnormal_impulse_conducting	1.59335229
28	MP0005620_abnormal_muscle_contractility	1.58088173
29	MP0003195_calcinosis	1.53253990
30	MP0002272_abnormal_nervous_system	1.49654665
31	MP0001764_abnormal_homeostasis	1.44156401
32	MP0001502_abnormal_circadian_rhythm	1.43061234
33	MP0005253_abnormal_eye_physiology	1.40834987
34	MP0002127_abnormal_cardiovascular_syste	1.37218330
35	MP0001440_abnormal_grooming_behavior	1.36212279
36	MP0005595_abnormal_vascular_smooth	1.36135621
37	MP0001905_abnormal_dopamine_level	1.36003763
38	MP0005636_abnormal_mineral_homeostasis	1.35796734
39	MP0000372_irregular_coat_pigmentation	1.31286640
40	MP0002736_abnormal_nociception_after	1.30579023
41	MP0008877_abnormal_DNA_methylation	1.29724778
42	MP0000747_muscle_weakness	1.28098834
43	MP0002108_abnormal_muscle_morphology	1.26594386
44	MP0008875_abnormal_xenobiotic_pharmacok	1.26165613
45	MP0002089_abnormal_postnatal_growth/wei	1.24331768
46	MP0003638_abnormal_response/metabolism_	1.23032517
47	MP0000778_abnormal_nervous_system	1.19679776
48	MP0001835_abnormal_antigen_presentation	1.19151766
49	MP0002572_abnormal_emotion/affect_behav	1.18085333
50	MP0001756_abnormal_urination	1.16412262
51	MP0000639_abnormal_adrenal_gland	1.16371739
52	MP0008872_abnormal_physiological_respon	1.15910006
53	MP0005083_abnormal_biliary_tract	1.15354185
54	MP0002148_abnormal_hypersensitivity_rea	1.11268194
55	MP0001970_abnormal_pain_threshold	1.09248502
56	MP0001986_abnormal_taste_sensitivity	1.08178989
57	MP0003959_abnormal_lean_body	1.06546371
58	MP0000685_abnormal_immune_system	1.04372772
59	MP0001486_abnormal_startle_reflex	1.02916825
60	MP0002557_abnormal_social/conspecific_i	1.01647045
61	MP0001661_extended_life_span	1.00268784
62	MP0009250_abnormal_appendicular_skeleto	0.99573583
63	MP0005085_abnormal_gallbladder_physiolo	0.99152049
64	MP0003724_increased_susceptibility_to	0.92971395
65	MP0003937_abnormal_limbs/digits/tail_de	0.92914765
66	MP0004036_abnormal_muscle_relaxation	0.92182033
67	MP0002095_abnormal_skin_pigmentation	0.91877219
68	MP0004484_altered_response_of	0.91752911
69	MP0003633_abnormal_nervous_system	0.89017372
70	MP0000534_abnormal_ureter_morphology	0.87653544
71	MP0010368_abnormal_lymphatic_system	0.83356557
72	MP0009764_decreased_sensitivity_to	0.83201291
73	MP0004043_abnormal_pH_regulation	0.83150667
74	MP0004085_abnormal_heartbeat	0.81892942
75	MP0005174_abnormal_tail_pigmentation	0.79700706
76	MP0002277_abnormal_respiratory_mucosa	0.79312672
77	MP0000427_abnormal_hair_cycle	0.78475465
78	MP0002269_muscular_atrophy	0.77993184
79	MP0008873_increased_physiological_sensi	0.77563125
80	MP0002063_abnormal_learning/memory/cond	0.76454391
81	MP0001727_abnormal_embryo_implantation	0.75643216
82	MP0002064_seizures	0.75338151
83	MP0000631_abnormal_neuroendocrine_gland	0.75040680
84	MP0008004_abnormal_stomach_pH	0.74503906
85	MP0003938_abnormal_ear_development	0.74191499
86	MP0002733_abnormal_thermal_nociception	0.73486661
87	MP0002928_abnormal_bile_duct	0.72036037
88	MP0006292_abnormal_olfactory_placode	0.71474203
89	MP0006072_abnormal_retinal_apoptosis	0.71309280
90	MP0004147_increased_porphyrin_level	0.71110385
91	MP0002254_reproductive_system_inflammat	0.70023019
92	MP0002184_abnormal_innervation	0.69498556
93	MP0002109_abnormal_limb_morphology	0.67615586
94	MP0001664_abnormal_digestion	0.66980902
95	MP0004742_abnormal_vestibular_system	0.66468728
96	MP0004133_heterotaxia	0.64991849
97	MP0005310_abnormal_salivary_gland	0.64798305
98	MP0001879_abnormal_lymphatic_vessel	0.63863548
99	MP0005000_abnormal_immune_tolerance	0.63660238
100	MP0001663_abnormal_digestive_system	0.63294575

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.92704444
2	Acute lymphatic leukemia (HP:0006721)	4.46211530
3	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.14111657
4	Palpebral edema (HP:0100540)	3.86579812
5	Abnormality of secondary sexual hair (HP:0009888)	3.67327110
6	Abnormality of the axillary hair (HP:0100134)	3.67327110
7	Ulnar deviation of the wrist (HP:0003049)	3.64198911
8	Pancreatic fibrosis (HP:0100732)	3.48187747
9	Visual hallucinations (HP:0002367)	3.39344758
10	Abnormality of cochlea (HP:0000375)	3.34096464
11	Attenuation of retinal blood vessels (HP:0007843)	3.32085653
12	Type II lissencephaly (HP:0007260)	3.31663035
13	Pigmentary retinal degeneration (HP:0001146)	3.31633227
14	True hermaphroditism (HP:0010459)	3.27799201
15	Hyperventilation (HP:0002883)	3.26421913
16	Genetic anticipation (HP:0003743)	3.21143124
17	Gaze-evoked nystagmus (HP:0000640)	3.10725628
18	Chorioretinal atrophy (HP:0000533)	3.04804260
19	Decreased circulating renin level (HP:0003351)	3.01460539
20	Pancreatic cysts (HP:0001737)	3.00337383
21	Inability to walk (HP:0002540)	2.95745383
22	Molar tooth sign on MRI (HP:0002419)	2.92228044
23	Abnormality of midbrain morphology (HP:0002418)	2.92228044
24	Morphological abnormality of the inner ear (HP:0011390)	2.91193241
25	Tinnitus (HP:0000360)	2.82142084
26	Biconcave vertebral bodies (HP:0004586)	2.78832956
27	Mutism (HP:0002300)	2.70265686
28	Hypothermia (HP:0002045)	2.64378444
29	Cerebellar dysplasia (HP:0007033)	2.59382101
30	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.58847483
31	Furrowed tongue (HP:0000221)	2.56911595
32	Broad-based gait (HP:0002136)	2.56364225
33	Nemaline bodies (HP:0003798)	2.55397156
34	Bone cyst (HP:0012062)	2.54767884
35	Progressive inability to walk (HP:0002505)	2.51279618
36	Clumsiness (HP:0002312)	2.49369705
37	Polydipsia (HP:0001959)	2.47980968
38	Abnormal drinking behavior (HP:0030082)	2.47980968
39	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.47923137
40	Abnormality of alanine metabolism (HP:0010916)	2.47923137
41	Hyperalaninemia (HP:0003348)	2.47923137
42	Fetal akinesia sequence (HP:0001989)	2.46346131
43	Fair hair (HP:0002286)	2.42468928
44	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.40343079
45	Absent phalangeal crease (HP:0006109)	2.39330340
46	Adactyly (HP:0009776)	2.38613748
47	Curly hair (HP:0002212)	2.36758616
48	Methylmalonic acidemia (HP:0002912)	2.32313779
49	Abolished electroretinogram (ERG) (HP:0000550)	2.31034692
50	Irregular vertebral endplates (HP:0003301)	2.30828873
51	Goiter (HP:0000853)	2.28977655
52	Homocystinuria (HP:0002156)	2.26661404
53	Abnormality of homocysteine metabolism (HP:0010919)	2.26661404
54	Gonadal dysgenesis (HP:0000133)	2.25362532
55	Hip contracture (HP:0003273)	2.19436170
56	Fibular aplasia (HP:0002990)	2.18336498
57	Alkalosis (HP:0001948)	2.18177979
58	Protruding tongue (HP:0010808)	2.16620077
59	Inappropriate behavior (HP:0000719)	2.16258825
60	Periorbital edema (HP:0100539)	2.11754926
61	Ventricular fibrillation (HP:0001663)	2.10543964
62	Abnormality of the wing of the ilium (HP:0011867)	2.08757001
63	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.08368254
64	Abnormal rod and cone electroretinograms (HP:0008323)	2.04470177
65	Progressive cerebellar ataxia (HP:0002073)	2.04393335
66	Facial edema (HP:0000282)	2.03751726
67	Abnormal finger flexion creases (HP:0006143)	2.02020291
68	Generalized hypopigmentation of hair (HP:0011358)	2.01549024
69	Ketosis (HP:0001946)	1.99448730
70	Abnormality of potassium homeostasis (HP:0011042)	1.98048354
71	Muscle fiber inclusion bodies (HP:0100299)	1.97534124
72	Hyperkalemia (HP:0002153)	1.97240869
73	Chronic mucocutaneous candidiasis (HP:0002728)	1.97202111
74	Recurrent cutaneous fungal infections (HP:0011370)	1.97202111
75	Congenital hepatic fibrosis (HP:0002612)	1.96472468
76	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	1.95346671
77	Chin dimple (HP:0010751)	1.95079933
78	Focal motor seizures (HP:0011153)	1.94529511
79	Abnormality of the vertebral endplates (HP:0005106)	1.93972217
80	Limited hip movement (HP:0008800)	1.93430219
81	Hypoproteinemia (HP:0003075)	1.93053099
82	Decreased central vision (HP:0007663)	1.92007985
83	Type 2 muscle fiber atrophy (HP:0003554)	1.91816663
84	Polyuria (HP:0000103)	1.91554380
85	Intellectual disability, profound (HP:0002187)	1.91190743
86	Male pseudohermaphroditism (HP:0000037)	1.90182882
87	Confusion (HP:0001289)	1.89992279
88	Radial bowing (HP:0002986)	1.86775476
89	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.86128901
90	Cerebral palsy (HP:0100021)	1.85168098
91	Metatarsus adductus (HP:0001840)	1.85153164
92	Hypokalemia (HP:0002900)	1.84129617
93	Morphological abnormality of the middle ear (HP:0008609)	1.83820618
94	Metabolic alkalosis (HP:0200114)	1.83783760
95	Nonprogressive disorder (HP:0003680)	1.82561297
96	Cystic liver disease (HP:0006706)	1.81802099
97	Stomach cancer (HP:0012126)	1.80473043
98	Abnormality of the renal cortex (HP:0011035)	1.75855485
99	Diplopia (HP:0000651)	1.75601196
100	Abnormality of binocular vision (HP:0011514)	1.75601196

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	8.77311108
2	FRK	6.07023366
3	ZAK	3.91153316
4	BCKDK	3.39764564
5	TNK2	3.12942851
6	ADRBK2	3.07688986
7	SIK2	2.36652895
8	MAP3K12	2.18440838
9	LATS1	2.17113208
10	NUAK1	1.79438660
11	MAP4K2	1.77890311
12	PINK1	1.73735062
13	TIE1	1.68207832
14	CDK19	1.48840616
15	RPS6KA4	1.46931492
16	PTK2B	1.38586944
17	MAP2K7	1.38209165
18	PNCK	1.36714552
19	BMPR2	1.36451763
20	TEC	1.33471676
21	CSF1R	1.29608393
22	SGK2	1.20284127
23	MUSK	1.17945944
24	TXK	1.14812659
25	OBSCN	1.14152343
26	ADRBK1	1.11568495
27	CASK	1.09317834
28	TRPM7	0.99403129
29	FES	0.96589180
30	FGR	0.96388468
31	TAOK3	0.96061366
32	MAPKAPK3	0.95780723
33	MAP4K1	0.95376891
34	FLT3	0.92349503
35	MAPK11	0.91188679
36	MYLK	0.90251432
37	NEK9	0.87526387
38	MKNK1	0.87114394
39	ITK	0.86970392
40	ERBB3	0.82883283
41	TAOK1	0.81438315
42	NEK2	0.77817859
43	ACVR1B	0.77805623
44	CAMK1	0.73954387
45	CAMK2A	0.71859235
46	CDK3	0.71842063
47	NTRK2	0.68408161
48	SGK223	0.67246842
49	SGK494	0.67246842
50	GRK5	0.65823799
51	RPS6KA5	0.64471276
52	GRK6	0.64332051
53	KIT	0.61787769
54	DAPK1	0.60689015
55	SYK	0.59190426
56	GRK1	0.57687853
57	PRKCQ	0.54436248
58	LYN	0.48710813
59	PHKG2	0.45433626
60	PHKG1	0.45433626
61	NME2	0.44603781
62	INSRR	0.44479777
63	IGF1R	0.44177258
64	ILK	0.43619621
65	STK3	0.43251191
66	ABL1	0.41517058
67	SGK3	0.41046370
68	CHUK	0.40508744
69	MAPKAPK5	0.39510274
70	MKNK2	0.38323490
71	PAK4	0.38104544
72	BTK	0.38085517
73	CSNK1A1L	0.37073347
74	CSNK1G1	0.35592723
75	DAPK2	0.35241428
76	PLK1	0.33625933
77	LCK	0.33530232
78	CAMK2G	0.33225938
79	MAPK13	0.33047950
80	TYRO3	0.31711723
81	RIPK4	0.31252207
82	PRKACA	0.29969952
83	IKBKB	0.29531439
84	CSNK1G2	0.28820117
85	CSNK1A1	0.28581042
86	CAMK1G	0.28356673
87	PIK3CG	0.26324039
88	PAK6	0.26055066
89	CSNK1G3	0.26038211
90	BMPR1B	0.25811536
91	PRKACG	0.25468828
92	MELK	0.24898152
93	WNK3	0.23912873
94	MAP2K1	0.23657375
95	JAK3	0.23347797
96	PLK3	0.22998485
97	AURKA	0.22696303
98	ERBB2	0.20984834
99	PLK2	0.20960234
100	PRKCE	0.20268127

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.80220404
2	Linoleic acid metabolism_Homo sapiens_hsa00591	3.55111404
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.52394615
4	Asthma_Homo sapiens_hsa05310	3.24312998
5	Graft-versus-host disease_Homo sapiens_hsa05332	2.88334649
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.73871046
7	Allograft rejection_Homo sapiens_hsa05330	2.56070517
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.38324670
9	Ether lipid metabolism_Homo sapiens_hsa00565	1.98585760
10	Type I diabetes mellitus_Homo sapiens_hsa04940	1.93673864
11	Long-term depression_Homo sapiens_hsa04730	1.89168011
12	Tryptophan metabolism_Homo sapiens_hsa00380	1.86645093
13	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.84009927
14	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.78593837
15	Serotonergic synapse_Homo sapiens_hsa04726	1.64415248
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.63724012
17	Circadian entrainment_Homo sapiens_hsa04713	1.62811281
18	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.60336476
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.51460859
20	Rheumatoid arthritis_Homo sapiens_hsa05323	1.44731684
21	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.43500708
22	Antigen processing and presentation_Homo sapiens_hsa04612	1.43449925
23	Morphine addiction_Homo sapiens_hsa05032	1.41136732
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.40567974
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.40154704
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.36459875
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.32075532
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.26857548
29	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.26750336
30	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.23491827
31	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.21293528
32	Glutamatergic synapse_Homo sapiens_hsa04724	1.19466533
33	Viral myocarditis_Homo sapiens_hsa05416	1.15077783
34	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.10413267
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.09392608
36	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.07153902
37	Caffeine metabolism_Homo sapiens_hsa00232	1.06626232
38	Platelet activation_Homo sapiens_hsa04611	1.05287632
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04523074
40	Protein export_Homo sapiens_hsa03060	1.04371835
41	Circadian rhythm_Homo sapiens_hsa04710	1.02179604
42	Calcium signaling pathway_Homo sapiens_hsa04020	1.01097248
43	Taste transduction_Homo sapiens_hsa04742	0.96069175
44	ABC transporters_Homo sapiens_hsa02010	0.95824067
45	Cardiac muscle contraction_Homo sapiens_hsa04260	0.93292415
46	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.92358993
47	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.91423902
48	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.90652026
49	Regulation of autophagy_Homo sapiens_hsa04140	0.88293922
50	Cholinergic synapse_Homo sapiens_hsa04725	0.88058639
51	Oxidative phosphorylation_Homo sapiens_hsa00190	0.86925800
52	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.86189761
53	Olfactory transduction_Homo sapiens_hsa04740	0.84914217
54	GABAergic synapse_Homo sapiens_hsa04727	0.84362203
55	Dopaminergic synapse_Homo sapiens_hsa04728	0.78891696
56	Nicotine addiction_Homo sapiens_hsa05033	0.78495938
57	Salivary secretion_Homo sapiens_hsa04970	0.74981944
58	Renin secretion_Homo sapiens_hsa04924	0.72818353
59	RNA degradation_Homo sapiens_hsa03018	0.68733088
60	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.68400230
61	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.63688158
62	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.63459202
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63332614
64	Propanoate metabolism_Homo sapiens_hsa00640	0.62991134
65	Alzheimers disease_Homo sapiens_hsa05010	0.62937674
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.62258896
67	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.62210227
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61774865
69	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.60434861
70	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.59606682
71	Butanoate metabolism_Homo sapiens_hsa00650	0.58755549
72	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.58072222
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56985233
74	VEGF signaling pathway_Homo sapiens_hsa04370	0.55511949
75	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.53865450
76	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.51644398
77	Parkinsons disease_Homo sapiens_hsa05012	0.51098177
78	Tight junction_Homo sapiens_hsa04530	0.51013995
79	Insulin secretion_Homo sapiens_hsa04911	0.50723385
80	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.50278665
81	Leishmaniasis_Homo sapiens_hsa05140	0.49585688
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46096840
83	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.41855384
84	Gastric acid secretion_Homo sapiens_hsa04971	0.40027052
85	Type II diabetes mellitus_Homo sapiens_hsa04930	0.39962283
86	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.39916694
87	Homologous recombination_Homo sapiens_hsa03440	0.39799388
88	GnRH signaling pathway_Homo sapiens_hsa04912	0.38382632
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.38095105
90	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.36078755
91	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.34957843
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.34562328
93	Ras signaling pathway_Homo sapiens_hsa04014	0.34366732
94	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.34153845
95	MAPK signaling pathway_Homo sapiens_hsa04010	0.33777967
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.32217406
97	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.31087617
98	Sulfur relay system_Homo sapiens_hsa04122	0.30233148
99	Renin-angiotensin system_Homo sapiens_hsa04614	0.28968241
100	Cocaine addiction_Homo sapiens_hsa05030	0.27455543

TARDBPP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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