TARDBPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pharyngeal system development (GO:0060037)7.62137768
2positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)6.67925073
3regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)6.67925073
4regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)6.19323958
5positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO6.19323958
6spinal cord association neuron differentiation (GO:0021527)6.00807154
7serotonin metabolic process (GO:0042428)5.77566605
8phosphatidylinositol acyl-chain remodeling (GO:0036149)5.62013890
9cell proliferation in forebrain (GO:0021846)5.53346651
10histone H4-K12 acetylation (GO:0043983)5.43485183
11cerebellar Purkinje cell differentiation (GO:0021702)5.35389265
12opioid receptor signaling pathway (GO:0038003)5.11680163
13kynurenine metabolic process (GO:0070189)5.05820270
14positive regulation of mRNA catabolic process (GO:0061014)5.02643414
15interkinetic nuclear migration (GO:0022027)4.95576422
16positive regulation of mRNA 3-end processing (GO:0031442)4.89288965
17urinary tract smooth muscle contraction (GO:0014848)4.87938209
18primary amino compound metabolic process (GO:1901160)4.81288924
19indole-containing compound catabolic process (GO:0042436)4.79759393
20indolalkylamine catabolic process (GO:0046218)4.79759393
21tryptophan catabolic process (GO:0006569)4.79759393
22phosphatidylserine acyl-chain remodeling (GO:0036150)4.73888221
23indole-containing compound metabolic process (GO:0042430)4.67037087
24regulation of short-term neuronal synaptic plasticity (GO:0048172)4.59853767
25peristalsis (GO:0030432)4.52146756
26multicellular organismal movement (GO:0050879)4.43984855
27musculoskeletal movement (GO:0050881)4.43984855
28skeletal muscle adaptation (GO:0043501)4.25277121
29regulation of rhodopsin mediated signaling pathway (GO:0022400)4.19594072
30cytoplasmic mRNA processing body assembly (GO:0033962)4.18899073
31forebrain neuron differentiation (GO:0021879)4.16890076
32regulation of mRNA catabolic process (GO:0061013)4.14583542
33striated muscle atrophy (GO:0014891)4.11632918
34indolalkylamine metabolic process (GO:0006586)4.08889178
35regulation of mRNA 3-end processing (GO:0031440)4.02151413
36negative regulation of sodium ion transport (GO:0010766)3.98716225
37response to gravity (GO:0009629)3.96376633
38positive regulation of mRNA processing (GO:0050685)3.93805203
39ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.89198554
40tryptophan metabolic process (GO:0006568)3.87403499
41neuronal action potential (GO:0019228)3.82751337
42rhodopsin mediated signaling pathway (GO:0016056)3.81950631
43phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.77489232
44megakaryocyte development (GO:0035855)3.77349682
45multicellular organism reproduction (GO:0032504)3.69575791
46regulation of skeletal muscle contraction (GO:0014819)3.67201066
47negative regulation of systemic arterial blood pressure (GO:0003085)3.58420045
48embryonic hemopoiesis (GO:0035162)3.54236067
49protein K48-linked ubiquitination (GO:0070936)3.53240638
50kidney morphogenesis (GO:0060993)3.52206154
51phospholipid catabolic process (GO:0009395)3.50528565
52locomotory exploration behavior (GO:0035641)3.45070614
53embryonic heart tube development (GO:0035050)3.44392814
54positive regulation of mRNA metabolic process (GO:1903313)3.40622688
55muscle atrophy (GO:0014889)3.29558514
56positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.17211413
57regulation of collateral sprouting (GO:0048670)3.16495966
58membrane depolarization during action potential (GO:0086010)3.14928047
59calcium ion import (GO:0070509)3.13854568
60exploration behavior (GO:0035640)3.08550914
61GMP metabolic process (GO:0046037)3.07174565
62phosphatidylcholine acyl-chain remodeling (GO:0036151)3.04375299
63behavioral response to ethanol (GO:0048149)3.03524392
64cell differentiation in hindbrain (GO:0021533)3.01014675
65heart trabecula morphogenesis (GO:0061384)3.00899233
66regulation of posttranscriptional gene silencing (GO:0060147)2.99136256
67regulation of gene silencing by miRNA (GO:0060964)2.99136256
68regulation of gene silencing by RNA (GO:0060966)2.99136256
69heparin biosynthetic process (GO:0030210)2.95763293
70heparin metabolic process (GO:0030202)2.95763293
71regulation of meiosis I (GO:0060631)2.93849884
72dopamine biosynthetic process (GO:0042416)2.92731440
73response to muscle activity (GO:0014850)2.92246288
74mitochondrial genome maintenance (GO:0000002)2.90479624
75negative regulation of protein localization to cell surface (GO:2000009)2.89730325
76histone H4-K5 acetylation (GO:0043981)2.89521732
77histone H4-K8 acetylation (GO:0043982)2.89521732
78cell differentiation in spinal cord (GO:0021515)2.87253025
79DNA replication checkpoint (GO:0000076)2.86375694
80seminiferous tubule development (GO:0072520)2.85644775
81thyroid hormone metabolic process (GO:0042403)2.80242333
82response to folic acid (GO:0051593)2.79745775
83organ formation (GO:0048645)2.74675909
84positive regulation of glomerulus development (GO:0090193)2.73957402
85endoderm formation (GO:0001706)2.73089475
86pantothenate metabolic process (GO:0015939)2.69541569
87amine catabolic process (GO:0009310)2.68823348
88cellular biogenic amine catabolic process (GO:0042402)2.68823348
89positive regulation of T cell mediated cytotoxicity (GO:0001916)2.68587336
90protein K6-linked ubiquitination (GO:0085020)2.60250648
91muscle filament sliding (GO:0030049)2.59579078
92actin-myosin filament sliding (GO:0033275)2.59579078
93one-carbon compound transport (GO:0019755)2.58417737
94cellular sodium ion homeostasis (GO:0006883)2.57324884
95eye photoreceptor cell development (GO:0042462)2.57236408
96protein-cofactor linkage (GO:0018065)2.55483880
97regulation of interleukin-8 secretion (GO:2000482)2.55022423
98negative regulation of keratinocyte proliferation (GO:0010839)2.53086986
99phosphatidylserine metabolic process (GO:0006658)2.53021711
100negative regulation of muscle hypertrophy (GO:0014741)2.52396345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.60827472
2VDR_22108803_ChIP-Seq_LS180_Human3.48863631
3EZH2_22144423_ChIP-Seq_EOC_Human2.96644324
4ZNF274_21170338_ChIP-Seq_K562_Hela2.68741137
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67146331
6TAF15_26573619_Chip-Seq_HEK293_Human2.63359081
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.56798168
8GBX2_23144817_ChIP-Seq_PC3_Human2.48051321
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47542155
10DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.43278558
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.28504615
12PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.19500491
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16600977
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12311329
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.12311329
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09391228
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99840938
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.96769054
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95589843
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.91912630
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89540571
22FUS_26573619_Chip-Seq_HEK293_Human1.85989358
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81620691
24ER_23166858_ChIP-Seq_MCF-7_Human1.79850617
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77950041
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71693840
27EWS_26573619_Chip-Seq_HEK293_Human1.70713018
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70365649
29BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.68189479
30P300_19829295_ChIP-Seq_ESCs_Human1.65208028
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.63015765
32STAT3_23295773_ChIP-Seq_U87_Human1.62383514
33AR_21572438_ChIP-Seq_LNCaP_Human1.61045354
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60110984
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.56837624
36TP53_22573176_ChIP-Seq_HFKS_Human1.54846874
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52573574
38FLI1_21867929_ChIP-Seq_TH2_Mouse1.49918476
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49402495
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48638027
41SMAD4_21799915_ChIP-Seq_A2780_Human1.48130364
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44797542
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43462333
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42888998
45RXR_22108803_ChIP-Seq_LS180_Human1.42706857
46REST_21632747_ChIP-Seq_MESCs_Mouse1.42521482
47RNF2_27304074_Chip-Seq_NSC_Mouse1.41115441
48AR_25329375_ChIP-Seq_VCAP_Human1.40930738
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.40854950
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39301323
51TCF4_23295773_ChIP-Seq_U87_Human1.34790308
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.34489730
53TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.30107711
54TAL1_26923725_Chip-Seq_HPCs_Mouse1.28046346
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27168312
56MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25274541
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23876187
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23585237
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.23060007
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21035955
61AR_20517297_ChIP-Seq_VCAP_Human1.19018168
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18593834
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17202274
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16250289
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15762829
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.15762829
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13974675
68RUNX2_22187159_ChIP-Seq_PCA_Human1.12028599
69GATA3_26560356_Chip-Seq_TH2_Human1.11925862
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11355384
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10318470
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.09071940
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08883193
74CBP_20019798_ChIP-Seq_JUKART_Human1.08883193
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08693643
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08597246
77KDM2B_26808549_Chip-Seq_REH_Human1.08179092
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.06751455
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.06540041
80DROSHA_22980978_ChIP-Seq_HELA_Human1.05361446
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05183414
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.03224481
83IRF1_19129219_ChIP-ChIP_H3396_Human1.02913091
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01588949
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01298813
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01123174
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01041644
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00899243
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00142460
90GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.00137157
91EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99910554
92RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99910554
93SOX2_21211035_ChIP-Seq_LN229_Gbm0.99234277
94RNF2_27304074_Chip-Seq_ESCs_Mouse0.98450596
95NCOR_22424771_ChIP-Seq_293T_Human0.98165983
96SMAD3_21741376_ChIP-Seq_EPCs_Human0.97056088
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.96730747
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96682707
99EZH2_27294783_Chip-Seq_ESCs_Mouse0.95445619
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94303715

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002876_abnormal_thyroid_physiology4.20877825
2MP0004145_abnormal_muscle_electrophysio3.51143744
3MP0003950_abnormal_plasma_membrane3.34883008
4MP0003646_muscle_fatigue3.30481515
5MP0004885_abnormal_endolymph3.27628927
6MP0005646_abnormal_pituitary_gland2.94535592
7MP0000569_abnormal_digit_pigmentation2.75529655
8MP0002138_abnormal_hepatobiliary_system2.40688125
9MP0006276_abnormal_autonomic_nervous2.23051510
10MP0001501_abnormal_sleep_pattern2.08339771
11MP0000230_abnormal_systemic_arterial2.07708043
12MP0001968_abnormal_touch/_nociception2.00961485
13MP0005503_abnormal_tendon_morphology1.98169393
14MP0002837_dystrophic_cardiac_calcinosis1.98145750
15MP0005671_abnormal_response_to1.97188826
16MP0006054_spinal_hemorrhage1.86949096
17MP0003880_abnormal_central_pattern1.85190381
18MP0009333_abnormal_splenocyte_physiolog1.83786534
19MP0004142_abnormal_muscle_tone1.79062004
20MP0005551_abnormal_eye_electrophysiolog1.78339714
21MP0001765_abnormal_ion_homeostasis1.77773078
22MP0004270_analgesia1.65410385
23MP0009046_muscle_twitch1.65385971
24MP0009745_abnormal_behavioral_response1.64800120
25MP0001485_abnormal_pinna_reflex1.63458793
26MP0002734_abnormal_mechanical_nocicepti1.61983857
27MP0003137_abnormal_impulse_conducting1.59335229
28MP0005620_abnormal_muscle_contractility1.58088173
29MP0003195_calcinosis1.53253990
30MP0002272_abnormal_nervous_system1.49654665
31MP0001764_abnormal_homeostasis1.44156401
32MP0001502_abnormal_circadian_rhythm1.43061234
33MP0005253_abnormal_eye_physiology1.40834987
34MP0002127_abnormal_cardiovascular_syste1.37218330
35MP0001440_abnormal_grooming_behavior1.36212279
36MP0005595_abnormal_vascular_smooth1.36135621
37MP0001905_abnormal_dopamine_level1.36003763
38MP0005636_abnormal_mineral_homeostasis1.35796734
39MP0000372_irregular_coat_pigmentation1.31286640
40MP0002736_abnormal_nociception_after1.30579023
41MP0008877_abnormal_DNA_methylation1.29724778
42MP0000747_muscle_weakness1.28098834
43MP0002108_abnormal_muscle_morphology1.26594386
44MP0008875_abnormal_xenobiotic_pharmacok1.26165613
45MP0002089_abnormal_postnatal_growth/wei1.24331768
46MP0003638_abnormal_response/metabolism_1.23032517
47MP0000778_abnormal_nervous_system1.19679776
48MP0001835_abnormal_antigen_presentation1.19151766
49MP0002572_abnormal_emotion/affect_behav1.18085333
50MP0001756_abnormal_urination1.16412262
51MP0000639_abnormal_adrenal_gland1.16371739
52MP0008872_abnormal_physiological_respon1.15910006
53MP0005083_abnormal_biliary_tract1.15354185
54MP0002148_abnormal_hypersensitivity_rea1.11268194
55MP0001970_abnormal_pain_threshold1.09248502
56MP0001986_abnormal_taste_sensitivity1.08178989
57MP0003959_abnormal_lean_body1.06546371
58MP0000685_abnormal_immune_system1.04372772
59MP0001486_abnormal_startle_reflex1.02916825
60MP0002557_abnormal_social/conspecific_i1.01647045
61MP0001661_extended_life_span1.00268784
62MP0009250_abnormal_appendicular_skeleto0.99573583
63MP0005085_abnormal_gallbladder_physiolo0.99152049
64MP0003724_increased_susceptibility_to0.92971395
65MP0003937_abnormal_limbs/digits/tail_de0.92914765
66MP0004036_abnormal_muscle_relaxation0.92182033
67MP0002095_abnormal_skin_pigmentation0.91877219
68MP0004484_altered_response_of0.91752911
69MP0003633_abnormal_nervous_system0.89017372
70MP0000534_abnormal_ureter_morphology0.87653544
71MP0010368_abnormal_lymphatic_system0.83356557
72MP0009764_decreased_sensitivity_to0.83201291
73MP0004043_abnormal_pH_regulation0.83150667
74MP0004085_abnormal_heartbeat0.81892942
75MP0005174_abnormal_tail_pigmentation0.79700706
76MP0002277_abnormal_respiratory_mucosa0.79312672
77MP0000427_abnormal_hair_cycle0.78475465
78MP0002269_muscular_atrophy0.77993184
79MP0008873_increased_physiological_sensi0.77563125
80MP0002063_abnormal_learning/memory/cond0.76454391
81MP0001727_abnormal_embryo_implantation0.75643216
82MP0002064_seizures0.75338151
83MP0000631_abnormal_neuroendocrine_gland0.75040680
84MP0008004_abnormal_stomach_pH0.74503906
85MP0003938_abnormal_ear_development0.74191499
86MP0002733_abnormal_thermal_nociception0.73486661
87MP0002928_abnormal_bile_duct0.72036037
88MP0006292_abnormal_olfactory_placode0.71474203
89MP0006072_abnormal_retinal_apoptosis0.71309280
90MP0004147_increased_porphyrin_level0.71110385
91MP0002254_reproductive_system_inflammat0.70023019
92MP0002184_abnormal_innervation0.69498556
93MP0002109_abnormal_limb_morphology0.67615586
94MP0001664_abnormal_digestion0.66980902
95MP0004742_abnormal_vestibular_system0.66468728
96MP0004133_heterotaxia0.64991849
97MP0005310_abnormal_salivary_gland0.64798305
98MP0001879_abnormal_lymphatic_vessel0.63863548
99MP0005000_abnormal_immune_tolerance0.63660238
100MP0001663_abnormal_digestive_system0.63294575

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.92704444
2Acute lymphatic leukemia (HP:0006721)4.46211530
3Decreased electroretinogram (ERG) amplitude (HP:0000654)4.14111657
4Palpebral edema (HP:0100540)3.86579812
5Abnormality of secondary sexual hair (HP:0009888)3.67327110
6Abnormality of the axillary hair (HP:0100134)3.67327110
7Ulnar deviation of the wrist (HP:0003049)3.64198911
8Pancreatic fibrosis (HP:0100732)3.48187747
9Visual hallucinations (HP:0002367)3.39344758
10Abnormality of cochlea (HP:0000375)3.34096464
11Attenuation of retinal blood vessels (HP:0007843)3.32085653
12Type II lissencephaly (HP:0007260)3.31663035
13Pigmentary retinal degeneration (HP:0001146)3.31633227
14True hermaphroditism (HP:0010459)3.27799201
15Hyperventilation (HP:0002883)3.26421913
16Genetic anticipation (HP:0003743)3.21143124
17Gaze-evoked nystagmus (HP:0000640)3.10725628
18Chorioretinal atrophy (HP:0000533)3.04804260
19Decreased circulating renin level (HP:0003351)3.01460539
20Pancreatic cysts (HP:0001737)3.00337383
21Inability to walk (HP:0002540)2.95745383
22Molar tooth sign on MRI (HP:0002419)2.92228044
23Abnormality of midbrain morphology (HP:0002418)2.92228044
24Morphological abnormality of the inner ear (HP:0011390)2.91193241
25Tinnitus (HP:0000360)2.82142084
26Biconcave vertebral bodies (HP:0004586)2.78832956
27Mutism (HP:0002300)2.70265686
28Hypothermia (HP:0002045)2.64378444
29Cerebellar dysplasia (HP:0007033)2.59382101
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.58847483
31Furrowed tongue (HP:0000221)2.56911595
32Broad-based gait (HP:0002136)2.56364225
33Nemaline bodies (HP:0003798)2.55397156
34Bone cyst (HP:0012062)2.54767884
35Progressive inability to walk (HP:0002505)2.51279618
36Clumsiness (HP:0002312)2.49369705
37Polydipsia (HP:0001959)2.47980968
38Abnormal drinking behavior (HP:0030082)2.47980968
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47923137
40Abnormality of alanine metabolism (HP:0010916)2.47923137
41Hyperalaninemia (HP:0003348)2.47923137
42Fetal akinesia sequence (HP:0001989)2.46346131
43Fair hair (HP:0002286)2.42468928
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.40343079
45Absent phalangeal crease (HP:0006109)2.39330340
46Adactyly (HP:0009776)2.38613748
47Curly hair (HP:0002212)2.36758616
48Methylmalonic acidemia (HP:0002912)2.32313779
49Abolished electroretinogram (ERG) (HP:0000550)2.31034692
50Irregular vertebral endplates (HP:0003301)2.30828873
51Goiter (HP:0000853)2.28977655
52Homocystinuria (HP:0002156)2.26661404
53Abnormality of homocysteine metabolism (HP:0010919)2.26661404
54Gonadal dysgenesis (HP:0000133)2.25362532
55Hip contracture (HP:0003273)2.19436170
56Fibular aplasia (HP:0002990)2.18336498
57Alkalosis (HP:0001948)2.18177979
58Protruding tongue (HP:0010808)2.16620077
59Inappropriate behavior (HP:0000719)2.16258825
60Periorbital edema (HP:0100539)2.11754926
61Ventricular fibrillation (HP:0001663)2.10543964
62Abnormality of the wing of the ilium (HP:0011867)2.08757001
63Increased neuronal autofluorescent lipopigment (HP:0002074)2.08368254
64Abnormal rod and cone electroretinograms (HP:0008323)2.04470177
65Progressive cerebellar ataxia (HP:0002073)2.04393335
66Facial edema (HP:0000282)2.03751726
67Abnormal finger flexion creases (HP:0006143)2.02020291
68Generalized hypopigmentation of hair (HP:0011358)2.01549024
69Ketosis (HP:0001946)1.99448730
70Abnormality of potassium homeostasis (HP:0011042)1.98048354
71Muscle fiber inclusion bodies (HP:0100299)1.97534124
72Hyperkalemia (HP:0002153)1.97240869
73Chronic mucocutaneous candidiasis (HP:0002728)1.97202111
74Recurrent cutaneous fungal infections (HP:0011370)1.97202111
75Congenital hepatic fibrosis (HP:0002612)1.96472468
76Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.95346671
77Chin dimple (HP:0010751)1.95079933
78Focal motor seizures (HP:0011153)1.94529511
79Abnormality of the vertebral endplates (HP:0005106)1.93972217
80Limited hip movement (HP:0008800)1.93430219
81Hypoproteinemia (HP:0003075)1.93053099
82Decreased central vision (HP:0007663)1.92007985
83Type 2 muscle fiber atrophy (HP:0003554)1.91816663
84Polyuria (HP:0000103)1.91554380
85Intellectual disability, profound (HP:0002187)1.91190743
86Male pseudohermaphroditism (HP:0000037)1.90182882
87Confusion (HP:0001289)1.89992279
88Radial bowing (HP:0002986)1.86775476
89Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86128901
90Cerebral palsy (HP:0100021)1.85168098
91Metatarsus adductus (HP:0001840)1.85153164
92Hypokalemia (HP:0002900)1.84129617
93Morphological abnormality of the middle ear (HP:0008609)1.83820618
94Metabolic alkalosis (HP:0200114)1.83783760
95Nonprogressive disorder (HP:0003680)1.82561297
96Cystic liver disease (HP:0006706)1.81802099
97Stomach cancer (HP:0012126)1.80473043
98Abnormality of the renal cortex (HP:0011035)1.75855485
99Diplopia (HP:0000651)1.75601196
100Abnormality of binocular vision (HP:0011514)1.75601196

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.77311108
2FRK6.07023366
3ZAK3.91153316
4BCKDK3.39764564
5TNK23.12942851
6ADRBK23.07688986
7SIK22.36652895
8MAP3K122.18440838
9LATS12.17113208
10NUAK11.79438660
11MAP4K21.77890311
12PINK11.73735062
13TIE11.68207832
14CDK191.48840616
15RPS6KA41.46931492
16PTK2B1.38586944
17MAP2K71.38209165
18PNCK1.36714552
19BMPR21.36451763
20TEC1.33471676
21CSF1R1.29608393
22SGK21.20284127
23MUSK1.17945944
24TXK1.14812659
25OBSCN1.14152343
26ADRBK11.11568495
27CASK1.09317834
28TRPM70.99403129
29FES0.96589180
30FGR0.96388468
31TAOK30.96061366
32MAPKAPK30.95780723
33MAP4K10.95376891
34FLT30.92349503
35MAPK110.91188679
36MYLK0.90251432
37NEK90.87526387
38MKNK10.87114394
39ITK0.86970392
40ERBB30.82883283
41TAOK10.81438315
42NEK20.77817859
43ACVR1B0.77805623
44CAMK10.73954387
45CAMK2A0.71859235
46CDK30.71842063
47NTRK20.68408161
48SGK2230.67246842
49SGK4940.67246842
50GRK50.65823799
51RPS6KA50.64471276
52GRK60.64332051
53KIT0.61787769
54DAPK10.60689015
55SYK0.59190426
56GRK10.57687853
57PRKCQ0.54436248
58LYN0.48710813
59PHKG20.45433626
60PHKG10.45433626
61NME20.44603781
62INSRR0.44479777
63IGF1R0.44177258
64ILK0.43619621
65STK30.43251191
66ABL10.41517058
67SGK30.41046370
68CHUK0.40508744
69MAPKAPK50.39510274
70MKNK20.38323490
71PAK40.38104544
72BTK0.38085517
73CSNK1A1L0.37073347
74CSNK1G10.35592723
75DAPK20.35241428
76PLK10.33625933
77LCK0.33530232
78CAMK2G0.33225938
79MAPK130.33047950
80TYRO30.31711723
81RIPK40.31252207
82PRKACA0.29969952
83IKBKB0.29531439
84CSNK1G20.28820117
85CSNK1A10.28581042
86CAMK1G0.28356673
87PIK3CG0.26324039
88PAK60.26055066
89CSNK1G30.26038211
90BMPR1B0.25811536
91PRKACG0.25468828
92MELK0.24898152
93WNK30.23912873
94MAP2K10.23657375
95JAK30.23347797
96PLK30.22998485
97AURKA0.22696303
98ERBB20.20984834
99PLK20.20960234
100PRKCE0.20268127

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.80220404
2Linoleic acid metabolism_Homo sapiens_hsa005913.55111404
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.52394615
4Asthma_Homo sapiens_hsa053103.24312998
5Graft-versus-host disease_Homo sapiens_hsa053322.88334649
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.73871046
7Allograft rejection_Homo sapiens_hsa053302.56070517
8Autoimmune thyroid disease_Homo sapiens_hsa053202.38324670
9Ether lipid metabolism_Homo sapiens_hsa005651.98585760
10Type I diabetes mellitus_Homo sapiens_hsa049401.93673864
11Long-term depression_Homo sapiens_hsa047301.89168011
12Tryptophan metabolism_Homo sapiens_hsa003801.86645093
13Ovarian steroidogenesis_Homo sapiens_hsa049131.84009927
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78593837
15Serotonergic synapse_Homo sapiens_hsa047261.64415248
16Nitrogen metabolism_Homo sapiens_hsa009101.63724012
17Circadian entrainment_Homo sapiens_hsa047131.62811281
18Arachidonic acid metabolism_Homo sapiens_hsa005901.60336476
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51460859
20Rheumatoid arthritis_Homo sapiens_hsa053231.44731684
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43500708
22Antigen processing and presentation_Homo sapiens_hsa046121.43449925
23Morphine addiction_Homo sapiens_hsa050321.41136732
24Primary immunodeficiency_Homo sapiens_hsa053401.40567974
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40154704
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.36459875
27Selenocompound metabolism_Homo sapiens_hsa004501.32075532
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26857548
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26750336
30Oxytocin signaling pathway_Homo sapiens_hsa049211.23491827
31Staphylococcus aureus infection_Homo sapiens_hsa051501.21293528
32Glutamatergic synapse_Homo sapiens_hsa047241.19466533
33Viral myocarditis_Homo sapiens_hsa054161.15077783
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.10413267
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09392608
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07153902
37Caffeine metabolism_Homo sapiens_hsa002321.06626232
38Platelet activation_Homo sapiens_hsa046111.05287632
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04523074
40Protein export_Homo sapiens_hsa030601.04371835
41Circadian rhythm_Homo sapiens_hsa047101.02179604
42Calcium signaling pathway_Homo sapiens_hsa040201.01097248
43Taste transduction_Homo sapiens_hsa047420.96069175
44ABC transporters_Homo sapiens_hsa020100.95824067
45Cardiac muscle contraction_Homo sapiens_hsa042600.93292415
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92358993
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91423902
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90652026
49Regulation of autophagy_Homo sapiens_hsa041400.88293922
50Cholinergic synapse_Homo sapiens_hsa047250.88058639
51Oxidative phosphorylation_Homo sapiens_hsa001900.86925800
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86189761
53Olfactory transduction_Homo sapiens_hsa047400.84914217
54GABAergic synapse_Homo sapiens_hsa047270.84362203
55Dopaminergic synapse_Homo sapiens_hsa047280.78891696
56Nicotine addiction_Homo sapiens_hsa050330.78495938
57Salivary secretion_Homo sapiens_hsa049700.74981944
58Renin secretion_Homo sapiens_hsa049240.72818353
59RNA degradation_Homo sapiens_hsa030180.68733088
60Hedgehog signaling pathway_Homo sapiens_hsa043400.68400230
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63688158
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63459202
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63332614
64Propanoate metabolism_Homo sapiens_hsa006400.62991134
65Alzheimers disease_Homo sapiens_hsa050100.62937674
66Systemic lupus erythematosus_Homo sapiens_hsa053220.62258896
67T cell receptor signaling pathway_Homo sapiens_hsa046600.62210227
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61774865
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60434861
70Vitamin digestion and absorption_Homo sapiens_hsa049770.59606682
71Butanoate metabolism_Homo sapiens_hsa006500.58755549
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58072222
73Chemical carcinogenesis_Homo sapiens_hsa052040.56985233
74VEGF signaling pathway_Homo sapiens_hsa043700.55511949
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.53865450
76Hematopoietic cell lineage_Homo sapiens_hsa046400.51644398
77Parkinsons disease_Homo sapiens_hsa050120.51098177
78Tight junction_Homo sapiens_hsa045300.51013995
79Insulin secretion_Homo sapiens_hsa049110.50723385
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50278665
81Leishmaniasis_Homo sapiens_hsa051400.49585688
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46096840
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.41855384
84Gastric acid secretion_Homo sapiens_hsa049710.40027052
85Type II diabetes mellitus_Homo sapiens_hsa049300.39962283
86Dorso-ventral axis formation_Homo sapiens_hsa043200.39916694
87Homologous recombination_Homo sapiens_hsa034400.39799388
88GnRH signaling pathway_Homo sapiens_hsa049120.38382632
89Basal cell carcinoma_Homo sapiens_hsa052170.38095105
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36078755
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34957843
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34562328
93Ras signaling pathway_Homo sapiens_hsa040140.34366732
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.34153845
95MAPK signaling pathway_Homo sapiens_hsa040100.33777967
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.32217406
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31087617
98Sulfur relay system_Homo sapiens_hsa041220.30233148
99Renin-angiotensin system_Homo sapiens_hsa046140.28968241
100Cocaine addiction_Homo sapiens_hsa050300.27455543

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