TARDBPP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 1 cell differentiation (GO:0045625)5.87010585
2relaxation of smooth muscle (GO:0044557)5.39693058
3negative regulation of T-helper cell differentiation (GO:0045623)5.20339276
4negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)5.20339276
5pyrimidine ribonucleoside catabolic process (GO:0046133)4.81726612
6nucleoside diphosphate catabolic process (GO:0009134)4.70443283
7positive regulation of T-helper 1 type immune response (GO:0002827)4.53642756
8fucose catabolic process (GO:0019317)4.40759977
9L-fucose metabolic process (GO:0042354)4.40759977
10L-fucose catabolic process (GO:0042355)4.40759977
11positive regulation of gamma-delta T cell activation (GO:0046645)4.32895814
12negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.17793212
13negative regulation by host of viral transcription (GO:0043922)4.09015829
14regulation of gamma-delta T cell differentiation (GO:0045586)4.03769666
15cytidine deamination (GO:0009972)4.02528626
16cytidine metabolic process (GO:0046087)4.02528626
17cytidine catabolic process (GO:0006216)4.02528626
18DNA deamination (GO:0045006)3.86288114
19ADP metabolic process (GO:0046031)3.85810565
20regulation of gamma-delta T cell activation (GO:0046643)3.83204786
21negative regulation of alpha-beta T cell differentiation (GO:0046639)3.82280691
22regulation of T-helper 1 type immune response (GO:0002825)3.78277796
23positive regulation of T-helper cell differentiation (GO:0045624)3.72863965
24interferon-gamma production (GO:0032609)3.72767996
25positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.72117141
26seminiferous tubule development (GO:0072520)3.71383520
27positive regulation of antigen processing and presentation (GO:0002579)3.70154445
28positive regulation of natural killer cell mediated immunity (GO:0002717)3.68227893
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.60297740
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.60297740
31positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.55228938
32peptidyl-histidine modification (GO:0018202)3.49518778
33negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.42361389
34negative regulation of T cell receptor signaling pathway (GO:0050860)3.40443485
35negative T cell selection (GO:0043383)3.39351503
36regulation of nuclear cell cycle DNA replication (GO:0033262)3.39053960
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.34434494
38positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.33906272
39lactate metabolic process (GO:0006089)3.33194376
40negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.31605915
41cardiolipin metabolic process (GO:0032048)3.29545443
42cellular response to exogenous dsRNA (GO:0071360)3.28693277
43positive regulation of defense response to virus by host (GO:0002230)3.27459691
44regulation of T cell receptor signaling pathway (GO:0050856)3.26628105
45regulation of B cell differentiation (GO:0045577)3.25667598
46regulation of T-helper 2 cell differentiation (GO:0045628)3.25312088
47parturition (GO:0007567)3.20297785
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.14982881
49regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.10619370
50positive regulation of protein sumoylation (GO:0033235)3.08550378
51negative regulation of type 2 immune response (GO:0002829)3.08333066
52regulation of natural killer cell mediated immunity (GO:0002715)3.04996984
53regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.04996984
54chaperone-mediated protein transport (GO:0072321)3.04627815
55positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.03292697
56regulation of dendritic cell antigen processing and presentation (GO:0002604)3.03238719
57retinal cone cell development (GO:0046549)3.01630257
58negative thymic T cell selection (GO:0045060)3.00538339
59positive regulation of cell killing (GO:0031343)2.96917084
60positive regulation of natural killer cell differentiation (GO:0032825)2.95700188
61regulation of B cell receptor signaling pathway (GO:0050855)2.93580073
62lymphoid progenitor cell differentiation (GO:0002320)2.91091075
63ribonucleoside diphosphate metabolic process (GO:0009185)2.89109559
64positive regulation of interleukin-17 production (GO:0032740)2.88524930
65modulation by host of symbiont transcription (GO:0052472)2.87481668
66modulation by host of viral transcription (GO:0043921)2.87481668
67regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.86819056
68modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.86707308
69negative regulation of T cell apoptotic process (GO:0070233)2.85984058
70thalamus development (GO:0021794)2.85213374
71positive thymic T cell selection (GO:0045059)2.84611883
72negative regulation of viral transcription (GO:0032897)2.83648806
73negative regulation of alpha-beta T cell activation (GO:0046636)2.83291478
74negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.82965898
75negative regulation of receptor activity (GO:2000272)2.79473464
76regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.77762444
77regulation of T-helper cell differentiation (GO:0045622)2.76061300
78DNA demethylation (GO:0080111)2.73175344
79positive regulation of B cell differentiation (GO:0045579)2.73016714
80DNA integration (GO:0015074)2.70686073
81regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.70311686
82pyrimidine nucleoside catabolic process (GO:0046135)2.68897646
83regulation of interleukin-1 beta secretion (GO:0050706)2.67733852
84urate metabolic process (GO:0046415)2.66960526
85regulation of hypersensitivity (GO:0002883)2.66686750
86cellular response to nicotine (GO:0071316)2.65881826
87negative regulation of smooth muscle contraction (GO:0045986)2.65431676
88regulation of platelet aggregation (GO:0090330)2.64483719
89positive regulation of interleukin-4 production (GO:0032753)2.64083610
90regulation of interleukin-2 biosynthetic process (GO:0045076)2.62908014
91regulation of MHC class II biosynthetic process (GO:0045346)2.62877774
92regulation of cell killing (GO:0031341)2.62877260
93regulation of leukocyte mediated cytotoxicity (GO:0001910)2.62838253
94positive regulation of alpha-beta T cell proliferation (GO:0046641)2.62738914
95positive regulation of interleukin-1 beta secretion (GO:0050718)2.60742998
96aggressive behavior (GO:0002118)2.58942394
97positive regulation of calcium-mediated signaling (GO:0050850)2.57737842
98positive regulation of humoral immune response (GO:0002922)2.57701467
99T cell receptor signaling pathway (GO:0050852)2.55699018
100amine catabolic process (GO:0009310)2.55494961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.01880873
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.62788900
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.48457614
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03660027
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.01071432
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.88340078
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.81570557
8ZNF274_21170338_ChIP-Seq_K562_Hela2.65223740
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.62795676
10IGF1R_20145208_ChIP-Seq_DFB_Human2.49620531
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46286547
12IRF1_19129219_ChIP-ChIP_H3396_Human2.46162427
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29021043
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.27206359
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.25518660
16MYB_26560356_Chip-Seq_TH2_Human2.24873975
17VDR_22108803_ChIP-Seq_LS180_Human2.21663276
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.21270074
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.14019971
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99835591
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88964108
22RUNX_20019798_ChIP-Seq_JUKART_Human1.86015836
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82200297
24FUS_26573619_Chip-Seq_HEK293_Human1.79086972
25MYC_18940864_ChIP-ChIP_HL60_Human1.75576699
26VDR_23849224_ChIP-Seq_CD4+_Human1.75441885
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.65745107
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59944791
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.59585665
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.55726474
31GATA3_27048872_Chip-Seq_THYMUS_Human1.55262462
32EZH2_22144423_ChIP-Seq_EOC_Human1.51038897
33GATA3_26560356_Chip-Seq_TH2_Human1.50609571
34AUTS2_25519132_ChIP-Seq_293T-REX_Human1.50207724
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49188708
36FOXP3_21729870_ChIP-Seq_TREG_Human1.48415734
37GBX2_23144817_ChIP-Seq_PC3_Human1.45843282
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44963299
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42926478
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41559033
41STAT1_20625510_ChIP-Seq_HELA_Human1.37172905
42EWS_26573619_Chip-Seq_HEK293_Human1.36307932
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34208857
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32396873
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32396873
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32396873
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.32213210
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31790380
49AR_20517297_ChIP-Seq_VCAP_Human1.29893340
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26960451
51GATA3_26560356_Chip-Seq_TH1_Human1.26057638
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25240050
53HTT_18923047_ChIP-ChIP_STHdh_Human1.24452570
54MYB_26560356_Chip-Seq_TH1_Human1.24274468
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.23221729
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.18870930
57PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18858163
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18688471
59ERG_20517297_ChIP-Seq_VCAP_Human1.16665155
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15833761
61P300_19829295_ChIP-Seq_ESCs_Human1.14327532
62HOXB7_26014856_ChIP-Seq_BT474_Human1.13530558
63TP53_22573176_ChIP-Seq_HFKS_Human1.12682641
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10024955
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09693159
66CBP_20019798_ChIP-Seq_JUKART_Human1.08268300
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08268300
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07738054
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.05768502
70ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03211171
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02940788
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02141900
73ELK1_19687146_ChIP-ChIP_HELA_Human1.01991878
74MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00571063
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98472317
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97977351
77ER_23166858_ChIP-Seq_MCF-7_Human0.97757024
78EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97001565
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96554754
80SMAD4_21741376_ChIP-Seq_EPCs_Human0.96145216
81TAL1_26923725_Chip-Seq_HPCs_Mouse0.94948922
82SOX2_19829295_ChIP-Seq_ESCs_Human0.94802552
83NANOG_19829295_ChIP-Seq_ESCs_Human0.94802552
84NCOR_22424771_ChIP-Seq_293T_Human0.93845029
85RNF2_27304074_Chip-Seq_NSC_Mouse0.93100585
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92907235
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91267534
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88529373
89ETS1_20019798_ChIP-Seq_JURKAT_Human0.88511999
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87039926
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86907005
92SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86103976
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84982096
94CBP_21632823_ChIP-Seq_H3396_Human0.84913476
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84224414
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83929525
97FOXA1_25329375_ChIP-Seq_VCAP_Human0.81179433
98FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81179433
99MYC_19829295_ChIP-Seq_ESCs_Human0.81019706
100OCT4_20526341_ChIP-Seq_ESCs_Human0.80695235

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.12671778
2MP0005671_abnormal_response_to3.33250777
3MP0002138_abnormal_hepatobiliary_system3.24837186
4MP0000372_irregular_coat_pigmentation3.23357509
5MP0001835_abnormal_antigen_presentation2.92500403
6MP0005464_abnormal_platelet_physiology2.88365592
7MP0009697_abnormal_copulation2.79720608
8MP0005085_abnormal_gallbladder_physiolo2.51139816
9MP0005645_abnormal_hypothalamus_physiol2.33107387
10MP0005000_abnormal_immune_tolerance2.24347586
11MP0002132_abnormal_respiratory_system2.21079125
12MP0003252_abnormal_bile_duct2.15367275
13MP0008877_abnormal_DNA_methylation2.11907012
14MP0008872_abnormal_physiological_respon2.08665397
15MP0005075_abnormal_melanosome_morpholog2.02455311
16MP0003011_delayed_dark_adaptation2.01640908
17MP0002148_abnormal_hypersensitivity_rea1.96213843
18MP0009785_altered_susceptibility_to1.95138754
19MP0003724_increased_susceptibility_to1.93279668
20MP0003763_abnormal_thymus_physiology1.93038045
21MP0008004_abnormal_stomach_pH1.90097168
22MP0001800_abnormal_humoral_immune1.87525244
23MP0008875_abnormal_xenobiotic_pharmacok1.82953991
24MP0000427_abnormal_hair_cycle1.82479098
25MP0003693_abnormal_embryo_hatching1.77991395
26MP0004145_abnormal_muscle_electrophysio1.77262977
27MP0003718_maternal_effect1.74533035
28MP0003950_abnormal_plasma_membrane1.73822261
29MP0002653_abnormal_ependyma_morphology1.71918861
30MP0002723_abnormal_immune_serum1.70293139
31MP0005387_immune_system_phenotype1.68936841
32MP0001790_abnormal_immune_system1.68936841
33MP0002009_preneoplasia1.68106601
34MP0008775_abnormal_heart_ventricle1.68067222
35MP0002420_abnormal_adaptive_immunity1.67016793
36MP0005551_abnormal_eye_electrophysiolog1.65205920
37MP0001819_abnormal_immune_cell1.64232589
38MP0002396_abnormal_hematopoietic_system1.58001057
39MP0006072_abnormal_retinal_apoptosis1.57563480
40MP0002736_abnormal_nociception_after1.57528044
41MP0002822_catalepsy1.56051310
42MP0002452_abnormal_antigen_presenting1.55530642
43MP0002398_abnormal_bone_marrow1.51683197
44MP0001968_abnormal_touch/_nociception1.49365954
45MP0005365_abnormal_bile_salt1.48979898
46MP0000465_gastrointestinal_hemorrhage1.46148385
47MP0001664_abnormal_digestion1.38573221
48MP0005646_abnormal_pituitary_gland1.38254632
49MP0005397_hematopoietic_system_phenotyp1.37204382
50MP0001545_abnormal_hematopoietic_system1.37204382
51MP0005025_abnormal_response_to1.36085329
52MP0000689_abnormal_spleen_morphology1.35735422
53MP0000383_abnormal_hair_follicle1.23478946
54MP0000716_abnormal_immune_system1.23020710
55MP0006082_CNS_inflammation1.22314950
56MP0003186_abnormal_redox_activity1.21183159
57MP0002722_abnormal_immune_system1.20070642
58MP0001873_stomach_inflammation1.19993718
59MP0000703_abnormal_thymus_morphology1.18058198
60MP0010155_abnormal_intestine_physiology1.16043102
61MP0002166_altered_tumor_susceptibility1.13028672
62MP0001845_abnormal_inflammatory_respons1.11966303
63MP0006035_abnormal_mitochondrial_morpho1.09447282
64MP0003121_genomic_imprinting1.08208162
65MP0005253_abnormal_eye_physiology1.06996584
66MP0001986_abnormal_taste_sensitivity1.06858841
67MP0008007_abnormal_cellular_replicative1.06726443
68MP0002006_tumorigenesis1.06669222
69MP0003436_decreased_susceptibility_to1.06588742
70MP0002429_abnormal_blood_cell1.05819455
71MP0009765_abnormal_xenobiotic_induced1.04520162
72MP0003866_abnormal_defecation1.03065968
73MP0003786_premature_aging1.02293538
74MP0005410_abnormal_fertilization1.02174006
75MP0003880_abnormal_central_pattern0.97249282
76MP0004808_abnormal_hematopoietic_stem0.94756226
77MP0010094_abnormal_chromosome_stability0.91001699
78MP0001533_abnormal_skeleton_physiology0.89398650
79MP0000685_abnormal_immune_system0.89051648
80MP0004084_abnormal_cardiac_muscle0.85222210
81MP0008995_early_reproductive_senescence0.84502541
82MP0006276_abnormal_autonomic_nervous0.84223244
83MP0002419_abnormal_innate_immunity0.82416530
84MP0001119_abnormal_female_reproductive0.81504032
85MP0009763_increased_sensitivity_to0.80563027
86MP0005423_abnormal_somatic_nervous0.80439209
87MP0009764_decreased_sensitivity_to0.76572993
88MP0010678_abnormal_skin_adnexa0.72053138
89MP0004947_skin_inflammation0.69930245
90MP0002019_abnormal_tumor_incidence0.67099967
91MP0004381_abnormal_hair_follicle0.65612621
92MP0001501_abnormal_sleep_pattern0.65167505
93MP0001764_abnormal_homeostasis0.63850412
94MP0010329_abnormal_lipoprotein_level0.62908575
95MP0002234_abnormal_pharynx_morphology0.62579684
96MP0001984_abnormal_olfaction0.61115946
97MP0008057_abnormal_DNA_replication0.61070257
98MP0003111_abnormal_nucleus_morphology0.59883252
99MP0003448_altered_tumor_morphology0.59855048
100MP0001929_abnormal_gametogenesis0.57963048

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)4.94638593
2Encephalitis (HP:0002383)4.28654110
3Abnormality of the prostate (HP:0008775)4.10719136
4IgG deficiency (HP:0004315)3.90476162
5Volvulus (HP:0002580)3.35709604
6T lymphocytopenia (HP:0005403)3.32064827
7Optic neuritis (HP:0100653)3.19806164
8Retrobulbar optic neuritis (HP:0100654)3.19806164
9Abnormality of T cell number (HP:0011839)3.18845123
10Eosinophilia (HP:0001880)3.05389810
11Acute hepatic failure (HP:0006554)2.98900194
12Granulocytopenia (HP:0001913)2.94444333
13Abnormality of eosinophils (HP:0001879)2.87947873
14Hypoproteinemia (HP:0003075)2.87338560
15Prostate neoplasm (HP:0100787)2.84730805
16Tongue fasciculations (HP:0001308)2.78574835
17Abnormality of pyrimidine metabolism (HP:0004353)2.76618385
18Abnormality of macular pigmentation (HP:0008002)2.71661088
19Severe combined immunodeficiency (HP:0004430)2.66626329
20Panhypogammaglobulinemia (HP:0003139)2.64327234
21Chronic diarrhea (HP:0002028)2.64134967
22Abnormality of B cell number (HP:0010975)2.58766003
23Abnormality of the labia minora (HP:0012880)2.52739770
24Agitation (HP:0000713)2.52197388
25Thyroiditis (HP:0100646)2.48234797
26Orchitis (HP:0100796)2.45742874
27Abnormality of male internal genitalia (HP:0000022)2.44750387
28Ridged nail (HP:0001807)2.44671468
29Central scotoma (HP:0000603)2.44111741
30Renal cortical cysts (HP:0000803)2.42315485
31Conjugated hyperbilirubinemia (HP:0002908)2.40128461
32Abnormality of midbrain morphology (HP:0002418)2.39128041
33Molar tooth sign on MRI (HP:0002419)2.39128041
34Hematochezia (HP:0002573)2.38352114
35Muscle fibrillation (HP:0010546)2.35737591
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.35086942
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.35086942
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33232774
39Leukocytosis (HP:0001974)2.30396506
40Abnormal finger flexion creases (HP:0006143)2.29456544
41Abnormality of T cells (HP:0002843)2.28270825
42Chronic otitis media (HP:0000389)2.27381477
43Abnormality of fatty-acid metabolism (HP:0004359)2.26991197
44Infantile muscular hypotonia (HP:0008947)2.22291797
45Oral leukoplakia (HP:0002745)2.21828730
46Type 2 muscle fiber atrophy (HP:0003554)2.21828121
47Dyschromatopsia (HP:0007641)2.20913182
48Chromsome breakage (HP:0040012)2.20309523
49Muscle fiber atrophy (HP:0100295)2.19954864
50Myositis (HP:0100614)2.18007053
51Nephronophthisis (HP:0000090)2.16566378
52Combined immunodeficiency (HP:0005387)2.14970744
53Abnormality of the renal cortex (HP:0011035)2.14666014
54Bifid tongue (HP:0010297)2.12175290
55Aplasia/Hypoplasia involving the musculature (HP:0001460)2.11579057
56Hyperglycinuria (HP:0003108)2.11466524
57Pancytopenia (HP:0001876)2.11287476
58Acute lymphatic leukemia (HP:0006721)2.10291904
59Short chin (HP:0000331)2.09357942
60Keratoconjunctivitis sicca (HP:0001097)2.08499480
61Enlarged kidneys (HP:0000105)2.08310468
62Abnormality of nucleobase metabolism (HP:0010932)2.07660409
63IgA deficiency (HP:0002720)2.06769412
64Congenital stationary night blindness (HP:0007642)2.06480732
65Keratoconjunctivitis (HP:0001096)2.04078548
66Autoimmune hemolytic anemia (HP:0001890)2.03233061
67Abnormality of the renal medulla (HP:0100957)2.02972875
68B lymphocytopenia (HP:0010976)2.02636301
69Palpitations (HP:0001962)1.97562038
70Pancreatic cysts (HP:0001737)1.96518138
71Abolished electroretinogram (ERG) (HP:0000550)1.94803916
72Aplasia/hypoplasia of the uterus (HP:0008684)1.92430715
73Hemiplegia (HP:0002301)1.91796783
74Gangrene (HP:0100758)1.90562847
753-Methylglutaconic aciduria (HP:0003535)1.90030876
76Hypophosphatemic rickets (HP:0004912)1.89416547
77Prolonged bleeding time (HP:0003010)1.85097801
78Ureteral obstruction (HP:0006000)1.82778842
79Decreased central vision (HP:0007663)1.80881712
80Rhabdomyolysis (HP:0003201)1.79946349
81Petechiae (HP:0000967)1.79944527
82Stenosis of the external auditory canal (HP:0000402)1.79618388
83Meningitis (HP:0001287)1.78851367
84Stomach cancer (HP:0012126)1.77601601
85Abnormality of glycine metabolism (HP:0010895)1.77076586
86Abnormality of serine family amino acid metabolism (HP:0010894)1.77076586
87Pulmonary fibrosis (HP:0002206)1.76758240
88Pulmonary infiltrates (HP:0002113)1.76221354
89Abnormality of purine metabolism (HP:0004352)1.76054670
90Cutis marmorata (HP:0000965)1.76043436
91Cone-rod dystrophy (HP:0000548)1.75737243
92Ureteral stenosis (HP:0000071)1.75448458
93Stomatitis (HP:0010280)1.74999203
94Recurrent cutaneous fungal infections (HP:0011370)1.74805625
95Chronic mucocutaneous candidiasis (HP:0002728)1.74805625
96Aplasia of the musculature (HP:0100854)1.74695553
97Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73010657
98Clitoromegaly (HP:0000057)1.72942360
99Autoamputation (HP:0001218)1.72631227
100Hypochromic microcytic anemia (HP:0004840)1.71632073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K27.15513221
2BCKDK3.50316106
3FLT33.26603482
4TEC3.19450329
5ITK2.97565664
6TXK2.91882081
7ARAF2.89219256
8TAOK32.75782934
9NUAK12.67735466
10KDR2.62280939
11KIT2.43801911
12GRK62.32743552
13SRPK12.03540876
14CSF1R1.98539007
15RAF11.80875728
16MATK1.76537384
17PASK1.70796856
18ERBB31.68999713
19TLK11.52891972
20NME11.51315815
21ALK1.47926502
22RPS6KA41.45858186
23PRKG21.42420049
24CDK191.30582588
25PIM21.23226598
26WNK31.21596165
27PRKCQ1.20251301
28MAP4K11.15140098
29FRK1.13489345
30SYK1.13001433
31BTK0.99592992
32NTRK10.99155241
33CAMKK10.95911801
34MAP3K130.92093157
35PLK40.90822946
36MKNK10.89955279
37STK160.85278308
38ZAK0.81716794
39ADRBK20.77925609
40LCK0.77543949
41NLK0.76377654
42GRK10.73758512
43MAP3K100.71443793
44LYN0.70680778
45EIF2AK10.70101906
46LMTK20.69945427
47FES0.68826836
48OXSR10.66658839
49IGF1R0.63432750
50BRAF0.62806044
51MAP2K20.57929787
52MKNK20.57580360
53IKBKB0.57221256
54CSNK1G20.55650266
55INSRR0.51465212
56PLK20.49265271
57KSR20.48463000
58PIK3CA0.47525217
59ATR0.47504300
60PRKCE0.47178777
61EPHB10.46837264
62CAMKK20.44903587
63FGR0.44616495
64PAK60.42856067
65PIK3CG0.41926667
66ERBB20.41309816
67HCK0.40608577
68LATS10.40196954
69VRK20.39735540
70PHKG10.39063402
71PHKG20.39063402
72BUB10.37746093
73TBK10.37324281
74PIM10.36648011
75NEK60.36509697
76CDC70.36272277
77CDK30.36219813
78TNIK0.35842257
79EPHA30.33713017
80PTK2B0.33031100
81RPS6KA60.31251770
82RPS6KA50.30675819
83BRD40.30117162
84PLK30.29866043
85TIE10.29805010
86PRKCA0.29467868
87DYRK30.29242477
88PAK40.28838281
89FYN0.28018672
90RPS6KC10.27566266
91RPS6KL10.27566266
92MST40.27146598
93PINK10.26275873
94BMX0.26228643
95EGFR0.25539131
96PAK10.25271797
97MAPK110.24911788
98CSNK2A10.24573838
99MOS0.24156801
100VRK10.23965590

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.37029814
2Allograft rejection_Homo sapiens_hsa053303.37351235
3Graft-versus-host disease_Homo sapiens_hsa053323.24862604
4Autoimmune thyroid disease_Homo sapiens_hsa053203.18452154
5Proteasome_Homo sapiens_hsa030502.81307514
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.62216849
7Type I diabetes mellitus_Homo sapiens_hsa049402.59254066
8Asthma_Homo sapiens_hsa053102.39685762
9Propanoate metabolism_Homo sapiens_hsa006402.37794482
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32486521
11Non-homologous end-joining_Homo sapiens_hsa034502.18830576
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18116878
13Hematopoietic cell lineage_Homo sapiens_hsa046402.06333036
14Homologous recombination_Homo sapiens_hsa034401.97993655
15Antigen processing and presentation_Homo sapiens_hsa046121.97499156
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.91523234
17T cell receptor signaling pathway_Homo sapiens_hsa046601.84282710
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.79405291
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53336409
20Phototransduction_Homo sapiens_hsa047441.50622189
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47997421
22One carbon pool by folate_Homo sapiens_hsa006701.45656590
23Linoleic acid metabolism_Homo sapiens_hsa005911.41622444
24Caffeine metabolism_Homo sapiens_hsa002321.40784455
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39319531
26Arachidonic acid metabolism_Homo sapiens_hsa005901.38726480
27Protein export_Homo sapiens_hsa030601.36254786
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33357776
29Rheumatoid arthritis_Homo sapiens_hsa053231.27500156
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.25603153
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23232524
32RNA polymerase_Homo sapiens_hsa030201.20499235
33Long-term depression_Homo sapiens_hsa047301.20492781
34Fanconi anemia pathway_Homo sapiens_hsa034601.19508633
35Olfactory transduction_Homo sapiens_hsa047401.18626994
36beta-Alanine metabolism_Homo sapiens_hsa004101.16050245
37Salivary secretion_Homo sapiens_hsa049701.14381795
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13139443
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12491806
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11911303
41RNA degradation_Homo sapiens_hsa030181.11763823
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10437266
43Fatty acid biosynthesis_Homo sapiens_hsa000611.08906393
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08674572
45Peroxisome_Homo sapiens_hsa041461.06350709
46Purine metabolism_Homo sapiens_hsa002301.02295379
47Systemic lupus erythematosus_Homo sapiens_hsa053220.90020966
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87848617
49Measles_Homo sapiens_hsa051620.85504322
50Platelet activation_Homo sapiens_hsa046110.85109934
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.83358121
52Viral myocarditis_Homo sapiens_hsa054160.83238812
53Retinol metabolism_Homo sapiens_hsa008300.82733251
54Spliceosome_Homo sapiens_hsa030400.81715256
55Glycerolipid metabolism_Homo sapiens_hsa005610.81458315
56Staphylococcus aureus infection_Homo sapiens_hsa051500.81102929
57Circadian entrainment_Homo sapiens_hsa047130.80442069
58Pyruvate metabolism_Homo sapiens_hsa006200.78977288
59Chemical carcinogenesis_Homo sapiens_hsa052040.77948178
60Oxidative phosphorylation_Homo sapiens_hsa001900.74714845
61Pyrimidine metabolism_Homo sapiens_hsa002400.74235223
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66960299
63Sulfur metabolism_Homo sapiens_hsa009200.65587663
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65560056
65Fatty acid metabolism_Homo sapiens_hsa012120.64043156
66Parkinsons disease_Homo sapiens_hsa050120.63495008
67Herpes simplex infection_Homo sapiens_hsa051680.62643042
68DNA replication_Homo sapiens_hsa030300.60330105
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.60324737
70Ether lipid metabolism_Homo sapiens_hsa005650.60192663
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59938961
72Nitrogen metabolism_Homo sapiens_hsa009100.58185030
73B cell receptor signaling pathway_Homo sapiens_hsa046620.57777318
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54608785
75Acute myeloid leukemia_Homo sapiens_hsa052210.47847645
76Ovarian steroidogenesis_Homo sapiens_hsa049130.43970932
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39851056
78RNA transport_Homo sapiens_hsa030130.39506240
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37424286
80Renin secretion_Homo sapiens_hsa049240.37423168
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.37297490
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37065036
83Serotonergic synapse_Homo sapiens_hsa047260.36192570
84Chemokine signaling pathway_Homo sapiens_hsa040620.35007973
85Tryptophan metabolism_Homo sapiens_hsa003800.34979694
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32875897
87Leishmaniasis_Homo sapiens_hsa051400.32161872
88Glutathione metabolism_Homo sapiens_hsa004800.31832530
89Metabolic pathways_Homo sapiens_hsa011000.29692820
90Malaria_Homo sapiens_hsa051440.29590823
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28814681
92Fatty acid degradation_Homo sapiens_hsa000710.28447689
93Ribosome_Homo sapiens_hsa030100.27727142
94ABC transporters_Homo sapiens_hsa020100.26972535
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.26372747
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23916710
97Morphine addiction_Homo sapiens_hsa050320.22551160
98Oxytocin signaling pathway_Homo sapiens_hsa049210.22417330
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.21515443
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20806506

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