TARM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of activation of Janus kinase activity (GO:0010533)5.70735501
2response to peptidoglycan (GO:0032494)5.56540872
3neutrophil activation involved in immune response (GO:0002283)5.42065756
4regulation of sarcomere organization (GO:0060297)5.40443738
5positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)5.27872643
6behavioral response to nicotine (GO:0035095)4.90068684
7regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.85458538
8negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.79533529
9negative regulation of translation, ncRNA-mediated (GO:0040033)4.79533529
10regulation of translation, ncRNA-mediated (GO:0045974)4.79533529
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.79517976
12T-helper 1 type immune response (GO:0042088)4.68227521
13regulation of T-helper 1 cell differentiation (GO:0045625)4.67599810
14G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.65000746
15positive regulation of interferon-alpha production (GO:0032727)4.60417173
16hydrogen peroxide biosynthetic process (GO:0050665)4.53066983
17positive regulation of chemokine biosynthetic process (GO:0045080)4.49369668
18lipopolysaccharide-mediated signaling pathway (GO:0031663)4.47791734
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.46765978
20granulocyte activation (GO:0036230)4.41557422
21regulation of female gonad development (GO:2000194)4.37624456
22superoxide anion generation (GO:0042554)4.37020833
23positive regulation of type 2 immune response (GO:0002830)4.35604708
24cellular response to type I interferon (GO:0071357)4.35211674
25type I interferon signaling pathway (GO:0060337)4.35211674
26regulation of interferon-alpha production (GO:0032647)4.34849343
27regulation of chemokine biosynthetic process (GO:0045073)4.30092180
28response to type I interferon (GO:0034340)4.28293697
29neutrophil activation (GO:0042119)4.25270973
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.18439402
31positive regulation by organism of defense response of other organism involved in symbiotic interact4.18439402
32modulation by symbiont of host immune response (GO:0052553)4.18439402
33positive regulation by symbiont of host defense response (GO:0052509)4.18439402
34modulation by symbiont of host defense response (GO:0052031)4.18439402
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.18439402
36respiratory burst (GO:0045730)4.06762420
37immunoglobulin mediated immune response (GO:0016064)4.06108041
38reactive oxygen species biosynthetic process (GO:1903409)4.04041101
39positive regulation of T-helper cell differentiation (GO:0045624)4.03078740
40defense response to protozoan (GO:0042832)4.00998919
41reflex (GO:0060004)3.96525616
42regulation of RIG-I signaling pathway (GO:0039535)3.91724053
43vocalization behavior (GO:0071625)3.89797433
44positive regulation of monocyte chemotaxis (GO:0090026)3.87666177
45positive regulation of interleukin-17 production (GO:0032740)3.87565947
46sperm motility (GO:0030317)3.87252456
47primary amino compound metabolic process (GO:1901160)3.84354568
48positive regulation of interleukin-12 production (GO:0032735)3.82558670
49natural killer cell mediated immunity (GO:0002228)3.82519122
50natural killer cell mediated cytotoxicity (GO:0042267)3.82519122
51positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.82146323
52response to pheromone (GO:0019236)3.81918559
53gamma-aminobutyric acid transport (GO:0015812)3.80575463
54cellular response to interferon-alpha (GO:0035457)3.79976665
55positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.79499030
56negative regulation of viral genome replication (GO:0045071)3.77746017
57acrosome reaction (GO:0007340)3.75595492
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74753673
59dendritic spine morphogenesis (GO:0060997)3.74601471
60cellular response to interferon-beta (GO:0035458)3.74327193
61positive regulation of mast cell activation (GO:0033005)3.74278166
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.72242348
63serotonin metabolic process (GO:0042428)3.71767999
64response to interferon-alpha (GO:0035455)3.71662410
65positive regulation of heat generation (GO:0031652)3.71320924
66protein localization to synapse (GO:0035418)3.70779850
67eosinophil chemotaxis (GO:0048245)3.70492857
68eosinophil migration (GO:0072677)3.68666937
69regulation of immunoglobulin secretion (GO:0051023)3.68282663
70response to misfolded protein (GO:0051788)3.68195809
71regulation of fever generation (GO:0031620)3.66883988
72regulation of dendritic cell antigen processing and presentation (GO:0002604)3.64524254
73lymphocyte chemotaxis (GO:0048247)3.64020436
74positive regulation of alpha-beta T cell proliferation (GO:0046641)3.63720672
75positive regulation of mast cell degranulation (GO:0043306)3.63687257
76positive regulation of mast cell activation involved in immune response (GO:0033008)3.63687257
77postsynaptic membrane organization (GO:0001941)3.62674727
78cellular ketone body metabolic process (GO:0046950)3.62433361
79leukocyte aggregation (GO:0070486)3.60683581
80indolalkylamine metabolic process (GO:0006586)3.60615390
81membrane depolarization during action potential (GO:0086010)3.57207761
82cellular response to exogenous dsRNA (GO:0071360)3.54540115
83production of molecular mediator involved in inflammatory response (GO:0002532)3.54300730
84interferon-gamma-mediated signaling pathway (GO:0060333)3.52483764
85positive regulation of CREB transcription factor activity (GO:0032793)3.50703155
86regulation of T-helper cell differentiation (GO:0045622)3.49043908
87NAD biosynthetic process (GO:0009435)3.48376845
88monocyte chemotaxis (GO:0002548)3.48128189
89protein polyglutamylation (GO:0018095)3.45670055
90positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.44995802
91T cell migration (GO:0072678)3.41830303
92leukocyte mediated cytotoxicity (GO:0001909)3.40685647
93cellular response to zinc ion (GO:0071294)3.40315118
94positive regulation of cellular amide metabolic process (GO:0034250)3.39904191
95response to protozoan (GO:0001562)3.38943256
96regulation of interferon-gamma biosynthetic process (GO:0045072)3.38395549
97positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.38285690
98regulation of T-helper 2 cell differentiation (GO:0045628)3.37527178
99positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.37264642
100response to interferon-beta (GO:0035456)3.36668004
101regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.36426664
102cilium or flagellum-dependent cell motility (GO:0001539)3.35554731
103positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.34899606
104myeloid dendritic cell differentiation (GO:0043011)3.32919010
105response to muramyl dipeptide (GO:0032495)3.32085865
106regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.31579749
107righting reflex (GO:0060013)3.31459313
108response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.31330315
109response to host immune response (GO:0052572)3.31330315
110positive regulation of natural killer cell differentiation (GO:0032825)3.31229387
111negative regulation of interleukin-17 production (GO:0032700)3.30572983
112positive regulation of lymphocyte migration (GO:2000403)3.29760848
113transmission of nerve impulse (GO:0019226)3.29278541
114cAMP catabolic process (GO:0006198)3.28379362
115L-fucose catabolic process (GO:0042355)3.26871228
116fucose catabolic process (GO:0019317)3.26871228
117L-fucose metabolic process (GO:0042354)3.26871228
118regulation of alpha-beta T cell proliferation (GO:0046640)3.26179232
119spinal cord motor neuron differentiation (GO:0021522)3.25086089
120regulation of T-helper 1 type immune response (GO:0002825)3.24809794
121kynurenine metabolic process (GO:0070189)3.23983317
122macrophage activation involved in immune response (GO:0002281)3.23046760
123calcium ion-dependent exocytosis (GO:0017156)3.21579451
124positive regulation of T-helper 1 type immune response (GO:0002827)3.21541306
125positive regulation of interferon-beta production (GO:0032728)3.20477601
126regulation of chronic inflammatory response (GO:0002676)3.20418876
127positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.19969931
128regulation of mononuclear cell migration (GO:0071675)3.19871581
129detection of light stimulus involved in visual perception (GO:0050908)3.18892759
130detection of light stimulus involved in sensory perception (GO:0050962)3.18892759
131indole-containing compound catabolic process (GO:0042436)3.18052860
132indolalkylamine catabolic process (GO:0046218)3.18052860
133tryptophan catabolic process (GO:0006569)3.18052860
134ketone body metabolic process (GO:1902224)3.16805625
135regulation of interleukin-17 production (GO:0032660)3.16271158
136positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.15516617
137neurotransmitter-gated ion channel clustering (GO:0072578)3.14233523
138microtubule depolymerization (GO:0007019)3.14008288
139peptidyl-threonine dephosphorylation (GO:0035970)3.13612203
140regulation of interleukin-12 production (GO:0032655)3.12946716
141regulation of mast cell degranulation (GO:0043304)3.12833001
142positive regulation of response to biotic stimulus (GO:0002833)3.12782386
143positive regulation of antigen processing and presentation (GO:0002579)3.12354803
144nonmotile primary cilium assembly (GO:0035058)3.11110702
145positive regulation of T cell cytokine production (GO:0002726)3.09930800
146regulation of hypersensitivity (GO:0002883)3.09562607
147positive regulation of defense response to virus by host (GO:0002230)3.09011698
148auditory behavior (GO:0031223)3.08465926
149multicellular organism reproduction (GO:0032504)3.08396715
150negative regulation of myeloid cell apoptotic process (GO:0033033)3.07999254
151glutamate receptor signaling pathway (GO:0007215)3.07907619
152regulation of memory T cell differentiation (GO:0043380)3.07666779
153positive regulation of synapse maturation (GO:0090129)3.07049040
154indole-containing compound metabolic process (GO:0042430)3.06676040
155peristalsis (GO:0030432)3.06566739
156regulation of glutamate receptor signaling pathway (GO:1900449)3.03900714
157negative regulation of systemic arterial blood pressure (GO:0003085)2.98495008
158interkinetic nuclear migration (GO:0022027)2.98435684
159epithelial cilium movement (GO:0003351)2.97227971
160fusion of sperm to egg plasma membrane (GO:0007342)2.96201910
161negative regulation of adenylate cyclase activity (GO:0007194)2.94560757
162protein localization to cilium (GO:0061512)2.92391831
163single strand break repair (GO:0000012)2.91366206
164cyclic nucleotide catabolic process (GO:0009214)2.89603385
165tryptophan metabolic process (GO:0006568)2.87411793
166alanine transport (GO:0032328)2.82682406
167regulation of short-term neuronal synaptic plasticity (GO:0048172)2.81466224
168nucleoside diphosphate catabolic process (GO:0009134)2.81302891
169protein K48-linked deubiquitination (GO:0071108)2.80732565
170negative regulation of cyclase activity (GO:0031280)2.80318404
171regulation of synapse maturation (GO:0090128)2.80130367
172cilium movement (GO:0003341)2.80007335
173monoubiquitinated protein deubiquitination (GO:0035520)2.79977463
174regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.79964718
175positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.79964718
176urinary tract smooth muscle contraction (GO:0014848)2.79383880
177potassium ion transmembrane transport (GO:0071805)2.79044400
178cellular potassium ion transport (GO:0071804)2.79044400
179detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.75300309
180positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.74282597
181positive regulation of guanylate cyclase activity (GO:0031284)2.74206833
182neuron cell-cell adhesion (GO:0007158)2.72000386
183microtubule polymerization or depolymerization (GO:0031109)2.70838628
184negative regulation of lyase activity (GO:0051350)2.70798188
185gamma-aminobutyric acid signaling pathway (GO:0007214)2.70535608
186multicellular organismal movement (GO:0050879)2.70454047
187musculoskeletal movement (GO:0050881)2.70454047
188positive regulation of sodium ion transmembrane transport (GO:1902307)2.70416613
189appendage development (GO:0048736)2.69390507
190limb development (GO:0060173)2.69390507
191behavioral response to ethanol (GO:0048149)2.69320321
192nicotinamide nucleotide biosynthetic process (GO:0019359)2.69094445
193pyridine nucleotide biosynthetic process (GO:0019363)2.69094445
194synaptic transmission, glutamatergic (GO:0035249)2.66961409
195mechanosensory behavior (GO:0007638)2.64745079
196axonemal dynein complex assembly (GO:0070286)2.63057638
197regulation of synaptic transmission, glutamatergic (GO:0051966)2.62449628
198regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.61262988
199positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.61262988
200protein K63-linked deubiquitination (GO:0070536)2.58415075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.98176088
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.96947033
3BP1_19119308_ChIP-ChIP_Hs578T_Human7.15558743
4EZH2_22144423_ChIP-Seq_EOC_Human6.48048559
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.55972314
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.32967137
7IRF8_27001747_Chip-Seq_BMDM_Mouse4.44101671
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.86741383
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.69128160
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.54157663
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.45635991
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.39330883
13DROSHA_22980978_ChIP-Seq_HELA_Human2.93386018
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.89257216
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.86203781
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.81290522
17ZNF274_21170338_ChIP-Seq_K562_Hela2.78772984
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.77693372
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.55241364
20VDR_22108803_ChIP-Seq_LS180_Human2.54780216
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.51192530
22GBX2_23144817_ChIP-Seq_PC3_Human2.47492089
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40745273
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39957646
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.19801530
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18481402
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14541835
28REST_21632747_ChIP-Seq_MESCs_Mouse2.11381687
29CBX2_27304074_Chip-Seq_ESCs_Mouse2.11031621
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.09802438
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09802438
32JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02499844
33AR_21572438_ChIP-Seq_LNCaP_Human2.00850125
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.96416074
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.94891095
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.93136130
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86722184
38SPI1_23547873_ChIP-Seq_NB4_Human1.86647928
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.83981014
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77818265
41VDR_24787735_ChIP-Seq_THP-1_Human1.73231255
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68981164
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66817058
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65596651
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.63284919
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62138110
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62125730
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60090767
49RNF2_27304074_Chip-Seq_NSC_Mouse1.59630142
50P300_19829295_ChIP-Seq_ESCs_Human1.57660145
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56912825
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56766560
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56144778
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55266782
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55217123
56STAT3_23295773_ChIP-Seq_U87_Human1.54136235
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51240385
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51185106
59SMAD4_21799915_ChIP-Seq_A2780_Human1.45797822
60ER_23166858_ChIP-Seq_MCF-7_Human1.45411131
61PU_27001747_Chip-Seq_BMDM_Mouse1.45031641
62TAF15_26573619_Chip-Seq_HEK293_Human1.44914689
63TCF4_23295773_ChIP-Seq_U87_Human1.43645877
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.43264347
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43101663
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41244286
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39042771
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37318554
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37270933
70MYB_26560356_Chip-Seq_TH2_Human1.37100971
71RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36953005
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36953005
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.35620623
74BCAT_22108803_ChIP-Seq_LS180_Human1.35307513
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34571711
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33052809
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.32707471
78FUS_26573619_Chip-Seq_HEK293_Human1.32294348
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32072827
80AR_25329375_ChIP-Seq_VCAP_Human1.29634943
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28947418
82CBP_20019798_ChIP-Seq_JUKART_Human1.28947418
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28802055
84* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28311570
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27499534
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26893277
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26859933
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25244807
89CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25063899
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.24324051
91RUNX_20019798_ChIP-Seq_JUKART_Human1.23798435
92GATA3_26560356_Chip-Seq_TH2_Human1.23734118
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23315347
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.22650793
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19649310
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19285803
97SMAD3_21741376_ChIP-Seq_ESCs_Human1.18374568
98RUNX2_22187159_ChIP-Seq_PCA_Human1.17316844
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.15958092
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15248805
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.14255839
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13743541
103SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13161713
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11562591
105KDM2B_26808549_Chip-Seq_REH_Human1.10090871
106IGF1R_20145208_ChIP-Seq_DFB_Human1.09548255
107NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09241207
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09241207
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08393078
110VDR_24763502_ChIP-Seq_THP-1_Human1.08126795
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08082798
112PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07731282
113RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07347683
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06381944
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06301755
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06292565
117LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05086749
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04961882
119* GATA3_21878914_ChIP-Seq_MCF-7_Human1.04460139
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04434892
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03584218
122SMAD4_21741376_ChIP-Seq_HESCs_Human1.03234633
123* RUNX1_22412390_ChIP-Seq_EML_Mouse1.02480567
124FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01465486
125FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01282593
126ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00780307
127AR_19668381_ChIP-Seq_PC3_Human1.00633497
128EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00438438
129MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99811499
130SOX2_19829295_ChIP-Seq_ESCs_Human0.99710455
131NANOG_19829295_ChIP-Seq_ESCs_Human0.99710455
132SCL_19346495_ChIP-Seq_HPC-7_Human0.99656983
133SPI1_23127762_ChIP-Seq_K562_Human0.99410055
134ERA_21632823_ChIP-Seq_H3396_Human0.98984607
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98371143
136SOX2_21211035_ChIP-Seq_LN229_Gbm0.96743424
137TCF4_22108803_ChIP-Seq_LS180_Human0.96641615
138MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96563324
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96412238
140P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96198892
141OCT4_20526341_ChIP-Seq_ESCs_Human0.96104302
142EGR1_19032775_ChIP-ChIP_M12_Human0.95986309
143MYB_26560356_Chip-Seq_TH1_Human0.95466968
144MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94470541
145IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94159124
146TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93518242
147GATA3_27048872_Chip-Seq_THYMUS_Human0.93322044
148RXR_22108803_ChIP-Seq_LS180_Human0.92852536
149AHR_22903824_ChIP-Seq_MCF-7_Human0.91709824
150OCT1_27270436_Chip-Seq_PROSTATE_Human0.90944323
151FLI1_21867929_ChIP-Seq_TH2_Mouse0.90700699
152RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90243659
153TP53_22573176_ChIP-Seq_HFKS_Human0.89239887
154MAF_26560356_Chip-Seq_TH1_Human0.85733542
155GATA2_21666600_ChIP-Seq_HMVEC_Human0.85122787
156* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84809698
157CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84225252
158GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83202562
159CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82248397
160SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81433949
161TP63_17297297_ChIP-ChIP_HaCaT_Human0.81416715
162GATA1_22025678_ChIP-Seq_K562_Human0.80747400
163SOX2_20726797_ChIP-Seq_SW620_Human0.80535631
164KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79686347
165CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.78742220
166GATA2_22383799_ChIP-Seq_G1ME_Mouse0.78718744
167ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76042137
168NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75364950
169PU1_27457419_Chip-Seq_LIVER_Mouse0.75211615
170STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.73463696
171CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.72198886
172STAT3_18555785_Chip-Seq_ESCs_Mouse0.71093793
173SUZ12_18555785_Chip-Seq_ESCs_Mouse0.70394557
174NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.70306111
175NMYC_18555785_Chip-Seq_ESCs_Mouse0.69733976
176SMAD1_18555785_Chip-Seq_ESCs_Mouse0.67861665
177BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66744850
178P53_22387025_ChIP-Seq_ESCs_Mouse0.66529429
179SMRT_27268052_Chip-Seq_Bcells_Human0.65892417
180KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.65458941
181RUNX1_27457419_Chip-Seq_LIVER_Mouse0.65022856
182RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.64850229
183CMYC_18555785_Chip-Seq_ESCs_Mouse0.63956656
184GATA3_21867929_ChIP-Seq_TH1_Mouse0.63825213
185EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.62239985
186PCGF2_27294783_Chip-Seq_ESCs_Mouse0.61935632
187E2F1_18555785_Chip-Seq_ESCs_Mouse0.60545326
188CJUN_26792858_Chip-Seq_BT549_Human0.60489685
189FLI1_27457419_Chip-Seq_LIVER_Mouse0.60293862
190POU3F2_20337985_ChIP-ChIP_501MEL_Human0.59384969
191SOX2_18555785_Chip-Seq_ESCs_Mouse0.57819271
192TRIM28_21343339_ChIP-Seq_HEK293_Human0.57515442
193JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57101246
194JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.56542873

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.08909075
2MP0009785_altered_susceptibility_to5.08484277
3MP0002148_abnormal_hypersensitivity_rea4.66228181
4MP0003724_increased_susceptibility_to4.00683864
5MP0003436_decreased_susceptibility_to3.97299200
6MP0006082_CNS_inflammation3.73854300
7MP0005000_abnormal_immune_tolerance3.50067924
8MP0005025_abnormal_response_to3.38874471
9MP0002419_abnormal_innate_immunity3.35095168
10MP0005671_abnormal_response_to3.15831420
11MP0005387_immune_system_phenotype3.05984944
12MP0001790_abnormal_immune_system3.05984944
13MP0000685_abnormal_immune_system2.80847448
14MP0009745_abnormal_behavioral_response2.79010789
15MP0003303_peritoneal_inflammation2.72548641
16MP0002723_abnormal_immune_serum2.67394680
17MP0002452_abnormal_antigen_presenting2.66632845
18MP0004510_myositis2.64223593
19MP0009764_decreased_sensitivity_to2.60349425
20MP0005423_abnormal_somatic_nervous2.54941581
21MP0002822_catalepsy2.54407070
22MP0005410_abnormal_fertilization2.52497556
23MP0001800_abnormal_humoral_immune2.50725868
24MP0002735_abnormal_chemical_nociception2.48167315
25MP0009046_muscle_twitch2.44042185
26MP0001486_abnormal_startle_reflex2.41681216
27MP0005377_hearing/vestibular/ear_phenot2.35716345
28MP0003878_abnormal_ear_physiology2.35716345
29MP0001968_abnormal_touch/_nociception2.34656386
30MP0001819_abnormal_immune_cell2.28104847
31MP0006292_abnormal_olfactory_placode2.23566950
32MP0002420_abnormal_adaptive_immunity2.21303127
33MP0004142_abnormal_muscle_tone2.19507252
34MP0005670_abnormal_white_adipose2.18538117
35MP0002572_abnormal_emotion/affect_behav2.17238957
36MP0002733_abnormal_thermal_nociception2.14725938
37MP0001440_abnormal_grooming_behavior2.14696210
38MP0001533_abnormal_skeleton_physiology2.12192380
39MP0001853_heart_inflammation2.09514823
40MP0005551_abnormal_eye_electrophysiolog2.05075037
41MP0001485_abnormal_pinna_reflex2.00070634
42MP0003448_altered_tumor_morphology1.99282331
43MP0001845_abnormal_inflammatory_respons1.97318997
44MP0001905_abnormal_dopamine_level1.97113348
45MP0002064_seizures1.96504010
46MP0003635_abnormal_synaptic_transmissio1.96487422
47MP0001970_abnormal_pain_threshold1.95953599
48MP0006276_abnormal_autonomic_nervous1.93016822
49MP0002557_abnormal_social/conspecific_i1.90021764
50MP0002006_tumorigenesis1.89672243
51MP0002272_abnormal_nervous_system1.89376223
52MP0002405_respiratory_system_inflammati1.84575002
53MP0005645_abnormal_hypothalamus_physiol1.83363497
54MP0008469_abnormal_protein_level1.83000199
55MP0005167_abnormal_blood-brain_barrier1.78523445
56MP0002736_abnormal_nociception_after1.77016848
57MP0004947_skin_inflammation1.76996468
58MP0008872_abnormal_physiological_respon1.76841928
59MP0005464_abnormal_platelet_physiology1.76487197
60MP0002067_abnormal_sensory_capabilities1.75870413
61MP0002734_abnormal_mechanical_nocicepti1.74886193
62MP0010155_abnormal_intestine_physiology1.74253264
63MP0003283_abnormal_digestive_organ1.73320368
64MP0002277_abnormal_respiratory_mucosa1.72469646
65MP0003075_altered_response_to1.71249168
66MP0004133_heterotaxia1.71154130
67MP0003186_abnormal_redox_activity1.68813035
68MP0004043_abnormal_pH_regulation1.67719844
69MP0004742_abnormal_vestibular_system1.66294956
70MP0000858_altered_metastatic_potential1.65922047
71MP0003879_abnormal_hair_cell1.64462801
72MP0005310_abnormal_salivary_gland1.62667236
73MP0000343_altered_response_to1.59971948
74MP0004147_increased_porphyrin_level1.59687169
75MP0002928_abnormal_bile_duct1.57737888
76MP0008877_abnormal_DNA_methylation1.55303166
77MP0000716_abnormal_immune_system1.54968006
78MP0009333_abnormal_splenocyte_physiolog1.52782420
79MP0002063_abnormal_learning/memory/cond1.52314111
80MP0005084_abnormal_gallbladder_morpholo1.52121065
81MP0009278_abnormal_bone_marrow1.48740421
82MP0005083_abnormal_biliary_tract1.45772767
83MP0001529_abnormal_vocalization1.39669008
84MP0001963_abnormal_hearing_physiology1.39662822
85MP0004782_abnormal_surfactant_physiolog1.39201152
86MP0002398_abnormal_bone_marrow1.37741286
87MP0000026_abnormal_inner_ear1.36354605
88MP0000631_abnormal_neuroendocrine_gland1.36240352
89MP0003698_abnormal_male_reproductive1.35409963
90MP0002998_abnormal_bone_remodeling1.34791597
91MP0004859_abnormal_synaptic_plasticity1.34238375
92MP0004885_abnormal_endolymph1.32852111
93MP0003880_abnormal_central_pattern1.30108878
94MP0004145_abnormal_muscle_electrophysio1.29980850
95MP0005164_abnormal_response_to1.29883055
96MP0005058_abnormal_lysosome_morphology1.28282849
97MP0001545_abnormal_hematopoietic_system1.27458480
98MP0005397_hematopoietic_system_phenotyp1.27458480
99MP0001986_abnormal_taste_sensitivity1.27321966
100MP0005166_decreased_susceptibility_to1.27164703
101MP0003718_maternal_effect1.21796409
102MP0003119_abnormal_digestive_system1.20683438
103MP0002184_abnormal_innervation1.17145748
104MP0002234_abnormal_pharynx_morphology1.16735005
105MP0002429_abnormal_blood_cell1.16325749
106MP0002163_abnormal_gland_morphology1.15508653
107MP0005253_abnormal_eye_physiology1.14481338
108MP0004924_abnormal_behavior1.12159996
109MP0005386_behavior/neurological_phenoty1.12159996
110MP0003890_abnormal_embryonic-extraembry1.10995404
111MP0003195_calcinosis1.10517851
112MP0005451_abnormal_body_composition1.09794428
113MP0009763_increased_sensitivity_to1.09591653
114MP0004085_abnormal_heartbeat1.06849932
115MP0002653_abnormal_ependyma_morphology1.06700072
116MP0008569_lethality_at_weaning1.03778380
117MP0002752_abnormal_somatic_nervous1.02774071
118MP0001765_abnormal_ion_homeostasis1.02507570
119MP0003690_abnormal_glial_cell1.01858993
120MP0003828_pulmonary_edema1.01528111
121MP0005390_skeleton_phenotype1.00808971
122MP0002909_abnormal_adrenal_gland1.00685780
123MP0000955_abnormal_spinal_cord0.99338989
124MP0002332_abnormal_exercise_endurance0.99221939
125MP0010386_abnormal_urinary_bladder0.98814473
126MP0002882_abnormal_neuron_morphology0.98705983
127MP0000230_abnormal_systemic_arterial0.97424939
128MP0005085_abnormal_gallbladder_physiolo0.97338755
129MP0001929_abnormal_gametogenesis0.97232731
130MP0000689_abnormal_spleen_morphology0.95080337
131MP0000778_abnormal_nervous_system0.93027388
132MP0003646_muscle_fatigue0.92163123
133MP0005195_abnormal_posterior_eye0.91924868
134MP0003172_abnormal_lysosome_physiology0.91704347
135MP0002722_abnormal_immune_system0.90574072
136MP0002229_neurodegeneration0.90161002
137MP0005646_abnormal_pituitary_gland0.88559200
138MP0003787_abnormal_imprinting0.88268063
139MP0003191_abnormal_cellular_cholesterol0.87118215
140MP0004130_abnormal_muscle_cell0.87018209
141MP0003137_abnormal_impulse_conducting0.85076900
142MP0000470_abnormal_stomach_morphology0.84701950
143MP0000049_abnormal_middle_ear0.83319667
144MP0002066_abnormal_motor_capabilities/c0.81230005
145MP0002138_abnormal_hepatobiliary_system0.80298741
146MP0003011_delayed_dark_adaptation0.79822135
147MP0002254_reproductive_system_inflammat0.79792127
148MP0001188_hyperpigmentation0.79532502
149MP0001346_abnormal_lacrimal_gland0.78182639
150MP0002938_white_spotting0.77827551
151MP0000569_abnormal_digit_pigmentation0.77434335
152MP0009053_abnormal_anal_canal0.77267178
153MP0003943_abnormal_hepatobiliary_system0.76378979
154MP0002249_abnormal_larynx_morphology0.75850710
155MP0005448_abnormal_energy_balance0.75682726
156MP0002102_abnormal_ear_morphology0.75620508
157MP0002152_abnormal_brain_morphology0.74525798
158MP0000371_diluted_coat_color0.71995573
159MP0000604_amyloidosis0.70531646
160MP0001348_abnormal_lacrimal_gland0.69114037
161MP0005535_abnormal_body_temperature0.68848716
162MP0001501_abnormal_sleep_pattern0.68418078
163MP0000249_abnormal_blood_vessel0.65151365
164MP0002166_altered_tumor_susceptibility0.65025395
165MP0003453_abnormal_keratinocyte_physiol0.64679310
166MP0005171_absent_coat_pigmentation0.63231909
167MP0003091_abnormal_cell_migration0.62946620
168MP0002933_joint_inflammation0.62022900
169MP0004858_abnormal_nervous_system0.60682415
170MP0002693_abnormal_pancreas_physiology0.59779958
171MP0003763_abnormal_thymus_physiology0.59405815
172MP0009765_abnormal_xenobiotic_induced0.58997223
173MP0004883_abnormal_blood_vessel0.58901178
174MP0003045_fibrosis0.57600555
175MP0001851_eye_inflammation0.55666089
176MP0010307_abnormal_tumor_latency0.54910621
177MP0002876_abnormal_thyroid_physiology0.54871509
178MP0008260_abnormal_autophagy0.53692523
179MP0005379_endocrine/exocrine_gland_phen0.53299322
180MP0000015_abnormal_ear_pigmentation0.53182452
181MP0000920_abnormal_myelination0.52580675
182MP0002136_abnormal_kidney_physiology0.52234916
183MP0003136_yellow_coat_color0.46922361
184MP0002638_abnormal_pupillary_reflex0.46668152
185MP0003866_abnormal_defecation0.46181710
186MP0000627_abnormal_mammary_gland0.46126052
187MP0003795_abnormal_bone_structure0.44903026
188MP0000372_irregular_coat_pigmentation0.43676401
189MP0004808_abnormal_hematopoietic_stem0.41824498

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.66984326
2Eczematoid dermatitis (HP:0000976)7.41915330
3Recurrent bacterial skin infections (HP:0005406)7.18261253
4Increased IgM level (HP:0003496)6.59891092
5Recurrent gram-negative bacterial infections (HP:0005420)6.47032003
6Genetic anticipation (HP:0003743)6.03543306
7Mediastinal lymphadenopathy (HP:0100721)5.95493125
8Autoimmune thrombocytopenia (HP:0001973)5.27514531
9Progressive cerebellar ataxia (HP:0002073)5.22925589
10Abnormality of macrophages (HP:0004311)5.20562098
11Elevated erythrocyte sedimentation rate (HP:0003565)5.06197795
12Gingivitis (HP:0000230)4.58026493
13Retinal dysplasia (HP:0007973)4.51157932
14Stomatitis (HP:0010280)4.36639754
15Recurrent skin infections (HP:0001581)4.29869870
16Hyperventilation (HP:0002883)4.23361410
17Vasculitis (HP:0002633)4.21929263
18Retrobulbar optic neuritis (HP:0100654)4.16838065
19Optic neuritis (HP:0100653)4.16838065
20Gastrointestinal infarctions (HP:0005244)4.13036088
21Myositis (HP:0100614)4.08561637
22Orchitis (HP:0100796)4.03063334
23Chronic obstructive pulmonary disease (HP:0006510)3.95616536
24Obstructive lung disease (HP:0006536)3.95616536
25Gaze-evoked nystagmus (HP:0000640)3.85085118
26Decreased circulating renin level (HP:0003351)3.85065435
27Decreased central vision (HP:0007663)3.80977426
28Thick nail (HP:0001805)3.78097317
29Abnormality of binocular vision (HP:0011514)3.75442080
30Diplopia (HP:0000651)3.75442080
31Recurrent fungal infections (HP:0002841)3.74880115
32Congenital stationary night blindness (HP:0007642)3.73570158
33Basal ganglia calcification (HP:0002135)3.72132478
34Nephronophthisis (HP:0000090)3.64185736
35Hypergammaglobulinemia (HP:0010702)3.62048704
36Prostate neoplasm (HP:0100787)3.56597289
37Severe visual impairment (HP:0001141)3.56251537
38Systemic lupus erythematosus (HP:0002725)3.50629180
39Attenuation of retinal blood vessels (HP:0007843)3.48256822
40Pancreatic cysts (HP:0001737)3.47410125
41Recurrent viral infections (HP:0004429)3.36545721
42Periodontitis (HP:0000704)3.34858109
43Molar tooth sign on MRI (HP:0002419)3.24137771
44Abnormality of midbrain morphology (HP:0002418)3.24137771
45Pustule (HP:0200039)3.24121802
46Vacuolated lymphocytes (HP:0001922)3.22235576
47Type II lissencephaly (HP:0007260)3.19936751
48Abnormality of the renal medulla (HP:0100957)3.16672156
49Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.11805511
50Sclerocornea (HP:0000647)3.09538497
51Interstitial pulmonary disease (HP:0006530)3.08052762
52Pulmonary infiltrates (HP:0002113)3.07970716
53Pancreatic fibrosis (HP:0100732)3.06940341
54Abnormal rod and cone electroretinograms (HP:0008323)3.03743612
55Bony spicule pigmentary retinopathy (HP:0007737)3.01599946
56Recurrent pneumonia (HP:0006532)2.99391517
57Abnormality of the diencephalon (HP:0010662)2.98251883
58Tetraparesis (HP:0002273)2.97484575
59Urticaria (HP:0001025)2.91177721
60Recurrent cutaneous fungal infections (HP:0011370)2.90691523
61Chronic mucocutaneous candidiasis (HP:0002728)2.90691523
62True hermaphroditism (HP:0010459)2.87299265
63Polydipsia (HP:0001959)2.82215622
64Abnormal drinking behavior (HP:0030082)2.82215622
65Cellulitis (HP:0100658)2.82177628
66Febrile seizures (HP:0002373)2.80267837
67Meningitis (HP:0001287)2.79755205
68Dynein arm defect of respiratory motile cilia (HP:0012255)2.78927667
69Absent/shortened dynein arms (HP:0200106)2.78927667
70Protruding tongue (HP:0010808)2.76325650
71Poor head control (HP:0002421)2.74092788
72Hemoptysis (HP:0002105)2.71286878
73Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.68701380
74Leukocytosis (HP:0001974)2.68327638
75Cystic liver disease (HP:0006706)2.65997732
76Recurrent lower respiratory tract infections (HP:0002783)2.65799741
77Epileptic encephalopathy (HP:0200134)2.64868763
78Broad-based gait (HP:0002136)2.64794200
79Hypoplastic ischia (HP:0003175)2.63731775
80Increased corneal curvature (HP:0100692)2.63079651
81Keratoconus (HP:0000563)2.63079651
82Chronic hepatic failure (HP:0100626)2.62842398
83Gingival bleeding (HP:0000225)2.59818316
84Premature loss of primary teeth (HP:0006323)2.59502091
85Abolished electroretinogram (ERG) (HP:0000550)2.57976434
86Pendular nystagmus (HP:0012043)2.56900907
87Petechiae (HP:0000967)2.54294179
88Parakeratosis (HP:0001036)2.54066797
89Autoimmune hemolytic anemia (HP:0001890)2.53076136
90Hyperkalemia (HP:0002153)2.51380596
91Hemiparesis (HP:0001269)2.51072299
92Abnormality of renin-angiotensin system (HP:0000847)2.50401660
93Focal motor seizures (HP:0011153)2.50141068
94Clumsiness (HP:0002312)2.49006643
95Abnormality of the renal cortex (HP:0011035)2.46647876
96Porencephaly (HP:0002132)2.46096363
97Birth length less than 3rd percentile (HP:0003561)2.46012525
98Chronic otitis media (HP:0000389)2.44382834
99Inability to walk (HP:0002540)2.44243554
100Abnormal ciliary motility (HP:0012262)2.42889040
101IgA deficiency (HP:0002720)2.41092802
102Tubular atrophy (HP:0000092)2.41014583
103Keratoconjunctivitis sicca (HP:0001097)2.38004358
104Medial flaring of the eyebrow (HP:0010747)2.37837434
105Purpura (HP:0000979)2.36903348
106Arterial thrombosis (HP:0004420)2.36364472
107Patellar aplasia (HP:0006443)2.35657942
108Agitation (HP:0000713)2.35201315
109Abnormal respiratory motile cilium morphology (HP:0005938)2.35132226
110Abnormal respiratory epithelium morphology (HP:0012253)2.35132226
111Gangrene (HP:0100758)2.32584694
112Abnormality of liposaccharide metabolism (HP:0010968)2.31802657
113Abnormality of glycosphingolipid metabolism (HP:0004343)2.31802657
114Abnormality of glycolipid metabolism (HP:0010969)2.31802657
115Osteomyelitis (HP:0002754)2.29078326
116Abnormality of the ischium (HP:0003174)2.28800268
117Dysmetric saccades (HP:0000641)2.28692690
118Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28327711
119Axonal loss (HP:0003447)2.27661602
120Abnormality of T cell number (HP:0011839)2.27152975
121Lissencephaly (HP:0001339)2.25039257
122IgG deficiency (HP:0004315)2.23467315
123Anorexia (HP:0002039)2.23143046
124Abnormality of macular pigmentation (HP:0008002)2.22647881
125Eosinophilia (HP:0001880)2.21388358
126Abnormality of the pericardium (HP:0001697)2.20607363
127Hepatosplenomegaly (HP:0001433)2.19199829
128Keratoconjunctivitis (HP:0001096)2.18661210
129Focal seizures (HP:0007359)2.18538483
130Cerebellar dysplasia (HP:0007033)2.17644234
131Aplasia/Hypoplasia of the patella (HP:0006498)2.17350926
132Gait imbalance (HP:0002141)2.15732464
133Joint swelling (HP:0001386)2.14346616
134Narrow nasal bridge (HP:0000446)2.14012524
135Increased neuronal autofluorescent lipopigment (HP:0002074)2.13786065
136Abnormality of alanine metabolism (HP:0010916)2.13746613
137Hyperalaninemia (HP:0003348)2.13746613
138Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13746613
139Prolonged neonatal jaundice (HP:0006579)2.13043809
140Chest pain (HP:0100749)2.12618785
141Abnormality of the pleura (HP:0002103)2.11814810
142Polyuria (HP:0000103)2.09160822
143Lower limb hyperreflexia (HP:0002395)2.08299657
144Impaired smooth pursuit (HP:0007772)2.08076156
145Abnormality of the prostate (HP:0008775)2.07808290
146Arthralgia (HP:0002829)2.07632986
147Abnormality of the pubic bones (HP:0003172)2.07054164
148Myokymia (HP:0002411)2.06859494
149Osteolytic defects of the phalanges of the hand (HP:0009771)2.06551791
150Osteolytic defects of the hand bones (HP:0009699)2.06551791
151Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.05117192
152Congenital sensorineural hearing impairment (HP:0008527)2.04600634
153Sepsis (HP:0100806)2.03788927
154Absent speech (HP:0001344)2.03507720
155Hypoplasia of the pons (HP:0012110)2.02615178
156Glomerulonephritis (HP:0000099)2.00917464
157Urinary bladder sphincter dysfunction (HP:0002839)2.00866191
158Abnormality of eosinophils (HP:0001879)1.96827326
159Abnormality of the pons (HP:0007361)1.96643315
160Abnormal respiratory motile cilium physiology (HP:0012261)1.96614746
161Abnormality of the vitreous humor (HP:0004327)1.96482397
162Skin ulcer (HP:0200042)1.96209847
163Intellectual disability, progressive (HP:0006887)1.96122814
164Increased cerebral lipofuscin (HP:0011813)1.94894638
165Congenital primary aphakia (HP:0007707)1.94752200
166Cleft eyelid (HP:0000625)1.94515859
167Bone pain (HP:0002653)1.92635279
168Anencephaly (HP:0002323)1.92452674
169Cheilitis (HP:0100825)1.92366071
170Hemorrhage of the eye (HP:0011885)1.92347533
171Widely spaced teeth (HP:0000687)1.91902739
172Amaurosis fugax (HP:0100576)1.91577218
173Dialeptic seizures (HP:0011146)1.91060318
174Granulocytopenia (HP:0001913)1.90499419
175Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90462729
176Confusion (HP:0001289)1.90149826
177Large for gestational age (HP:0001520)1.88006657
178Peritonitis (HP:0002586)1.87603021
179Aplasia/Hypoplasia of the lens (HP:0008063)1.87363932
180Proximal tubulopathy (HP:0000114)1.87297312
181Bulbous nose (HP:0000414)1.86333914
182Genital tract atresia (HP:0001827)1.85779089
183Pachygyria (HP:0001302)1.85158597
184Abnormality of cells of the lymphoid lineage (HP:0012140)1.85034984
185Abnormality of T cells (HP:0002843)1.84738972
186Abnormality of T cell physiology (HP:0011840)1.84107807
187Abnormality of potassium homeostasis (HP:0011042)1.83424630
188Congenital hepatic fibrosis (HP:0002612)1.83261444
189Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82963018
190Hyperaldosteronism (HP:0000859)1.82069970
191Neutropenia (HP:0001875)1.80973177
192Disinhibition (HP:0000734)1.80251399
193Bile duct proliferation (HP:0001408)1.80198194
194Abnormal biliary tract physiology (HP:0012439)1.80198194
195Nephritis (HP:0000123)1.80052856
196T lymphocytopenia (HP:0005403)1.79907186
197Combined immunodeficiency (HP:0005387)1.79429600
198Vaginal atresia (HP:0000148)1.77750621
199Abnormal delayed hypersensitivity skin test (HP:0002963)1.76754643
200Abnormal urine output (HP:0012590)1.76714834

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.20979827
2PBK5.38274454
3MAP3K145.21510833
4RIPK45.00325886
5CASK4.10367615
6BLK3.69366449
7TBK13.65596977
8IRAK43.53671546
9ACVR1B3.15070015
10IRAK33.10865396
11IKBKB2.79950432
12IKBKE2.74190598
13TYK22.65881605
14JAK32.64198051
15TXK2.27561959
16BMPR22.20872205
17WNK32.08624712
18PIM22.05899363
19NTRK32.05271531
20DAPK21.99054760
21PNCK1.96075330
22MAPK131.95980193
23MAP3K131.93687190
24MAP3K41.87094456
25JAK11.82903302
26CHUK1.77469569
27MAPK151.69267656
28CAMKK11.67217221
29GRK11.64168432
30MAP4K21.62360982
31WNK41.60896257
32TLK11.53627669
33EIF2AK21.51404735
34NTRK21.50735555
35MST41.48751369
36MARK11.46190454
37CAMK1G1.43083401
38TNK21.37104793
39CSK1.36513893
40ADRBK11.35640217
41MAP4K11.32703878
42PTK2B1.31510597
43SIK31.30496242
44ABL21.30195726
45CAMKK21.30172795
46SYK1.26723685
47KIT1.24946400
48CAMK1D1.23818149
49YES11.23371717
50NEK21.23032179
51ZAP701.17640826
52ERBB31.17246021
53STK41.14756000
54LYN1.13833768
55HCK1.12171558
56OXSR11.11240348
57DDR21.10306881
58IRAK11.09741347
59PRKCG1.09425836
60TAF11.09280053
61BMX1.05813806
62MST1R1.04661652
63STK38L1.04118813
64PIM11.00883899
65IRAK20.98611815
66BTK0.97957859
67ARAF0.97415774
68JAK20.93239874
69TGFBR10.90901835
70FGR0.90128596
71STK390.89741285
72DYRK20.89027677
73MKNK20.88957347
74MAP2K70.87838261
75LCK0.87447441
76PASK0.86692432
77MAP3K50.86388641
78GRK70.86264831
79MATK0.83762108
80PINK10.83629248
81MARK30.82879629
82TEC0.82782716
83NEK90.82753144
84CAMK10.82740016
85MAP3K120.81864157
86NME10.81498055
87EPHB10.80383300
88STK380.80216769
89PRKCD0.80148890
90NME20.79631092
91CLK10.78627913
92PRKCH0.75775626
93ADRBK20.75653597
94CAMK40.75237178
95TAOK30.74738219
96ZAK0.73905759
97RPS6KA40.72573169
98TNIK0.72432809
99TRPM70.70970530
100MAPKAPK50.70041595
101MAP2K60.67804832
102CAMK2A0.67719868
103RPS6KA60.67114196
104EPHA30.65052063
105ABL10.63985951
106BMPR1B0.63304680
107ERN10.62982906
108TYRO30.60286791
109PRKCQ0.59703078
110PRKAA20.59612888
111DYRK1A0.58126494
112ERBB40.57952499
113FGFR30.57825950
114TESK10.57780629
115STK110.56761922
116BCR0.55903384
117TIE10.55880066
118ERBB20.55130312
119PRKAA10.53824360
120CSF1R0.53711909
121PRKACA0.51247864
122PLK20.50569356
123CDK30.48574324
124CDK190.48370083
125FGFR40.47052578
126MAP3K70.46803541
127MAP3K110.46610819
128PLK40.46147791
129FES0.45917823
130SGK10.44720686
131PRKCZ0.43923549
132EGFR0.43096596
133PRKG10.42613804
134PIK3CA0.42106460
135PHKG10.40770017
136PHKG20.40770017
137PRKCA0.40242815
138SGK2230.39900394
139SGK4940.39900394
140STK30.36868398
141PKN10.36377989
142RPS6KA20.36369154
143CDK120.35985723
144SGK20.35799566
145PAK30.35290644
146MAP3K10.34929660
147PRPF4B0.34686204
148GSK3B0.33518621
149NLK0.32860558
150NUAK10.31866452
151MOS0.31722555
152PRKCB0.31703719
153ITK0.29696995
154RPS6KA30.29483778
155MAP2K40.29470676
156GRK60.28985019
157DAPK30.28477119
158MKNK10.28287600
159PIK3CG0.27598825
160AKT10.27478521
161CDK50.26946218
162MAPKAPK20.26378551
163PRKCE0.25817858
164SIK20.25603033
165EIF2AK10.23709700
166FYN0.22055855
167STK240.21333484
168IGF1R0.19976504
169STK100.16764458
170MUSK0.16109571
171INSRR0.15982955
172RPS6KA10.14808519
173PRKG20.13968923
174EIF2AK30.13188936
175RPS6KA50.13014779
176INSR0.12995551
177NEK60.11510040
178SRC0.10252851
179PDPK10.09332914

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.46175218
2Allograft rejection_Homo sapiens_hsa053303.98529934
3Nicotine addiction_Homo sapiens_hsa050333.74003170
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.32897122
5Leishmaniasis_Homo sapiens_hsa051403.23034252
6Type I diabetes mellitus_Homo sapiens_hsa049403.12042466
7Taste transduction_Homo sapiens_hsa047423.07858560
8Toll-like receptor signaling pathway_Homo sapiens_hsa046203.03010516
9Morphine addiction_Homo sapiens_hsa050322.98174328
10Asthma_Homo sapiens_hsa053102.88192757
11Legionellosis_Homo sapiens_hsa051342.80876865
12Staphylococcus aureus infection_Homo sapiens_hsa051502.71988786
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.71860425
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.60679340
15Linoleic acid metabolism_Homo sapiens_hsa005912.52446800
16GABAergic synapse_Homo sapiens_hsa047272.49582328
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.49159941
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46140499
19Rheumatoid arthritis_Homo sapiens_hsa053232.44621266
20Intestinal immune network for IgA production_Homo sapiens_hsa046722.37871096
21Pertussis_Homo sapiens_hsa051332.33121115
22Glutamatergic synapse_Homo sapiens_hsa047242.32350215
23Phototransduction_Homo sapiens_hsa047442.32239978
24Malaria_Homo sapiens_hsa051442.31320567
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.28952211
26African trypanosomiasis_Homo sapiens_hsa051432.26199906
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.20468957
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.20407447
29Butanoate metabolism_Homo sapiens_hsa006502.18937612
30Measles_Homo sapiens_hsa051622.18610506
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.18331546
32Circadian entrainment_Homo sapiens_hsa047132.16169315
33Autoimmune thyroid disease_Homo sapiens_hsa053202.05555850
34Serotonergic synapse_Homo sapiens_hsa047262.05054063
35Maturity onset diabetes of the young_Homo sapiens_hsa049502.02708801
36Influenza A_Homo sapiens_hsa051641.99497986
37Tuberculosis_Homo sapiens_hsa051521.96356342
38TNF signaling pathway_Homo sapiens_hsa046681.96251521
39Olfactory transduction_Homo sapiens_hsa047401.91760579
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86483685
41Osteoclast differentiation_Homo sapiens_hsa043801.83712591
42Insulin secretion_Homo sapiens_hsa049111.82977719
43Salmonella infection_Homo sapiens_hsa051321.81502036
44Nitrogen metabolism_Homo sapiens_hsa009101.76443783
45Herpes simplex infection_Homo sapiens_hsa051681.69501397
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.65407463
47Cholinergic synapse_Homo sapiens_hsa047251.51663306
48Cocaine addiction_Homo sapiens_hsa050301.50521572
49ABC transporters_Homo sapiens_hsa020101.48308257
50Tryptophan metabolism_Homo sapiens_hsa003801.47171040
51Hematopoietic cell lineage_Homo sapiens_hsa046401.43646387
52Gastric acid secretion_Homo sapiens_hsa049711.41264553
53Phagosome_Homo sapiens_hsa041451.41095972
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37156423
55Calcium signaling pathway_Homo sapiens_hsa040201.35631576
56Toxoplasmosis_Homo sapiens_hsa051451.35457784
57Chemokine signaling pathway_Homo sapiens_hsa040621.35385846
58Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34048831
59Selenocompound metabolism_Homo sapiens_hsa004501.33556161
60Vascular smooth muscle contraction_Homo sapiens_hsa042701.28988751
61Dopaminergic synapse_Homo sapiens_hsa047281.26150018
62Salivary secretion_Homo sapiens_hsa049701.25242646
63Oxytocin signaling pathway_Homo sapiens_hsa049211.24693791
64Jak-STAT signaling pathway_Homo sapiens_hsa046301.19777690
65Viral myocarditis_Homo sapiens_hsa054161.18172998
66Primary bile acid biosynthesis_Homo sapiens_hsa001201.15860462
67Primary immunodeficiency_Homo sapiens_hsa053401.08728204
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07456413
69Long-term depression_Homo sapiens_hsa047301.06357701
70Apoptosis_Homo sapiens_hsa042101.06082666
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04035271
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03439709
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01295123
74Caffeine metabolism_Homo sapiens_hsa002321.00655483
75Shigellosis_Homo sapiens_hsa051311.00360218
76Prion diseases_Homo sapiens_hsa050201.00111243
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.98208648
78cAMP signaling pathway_Homo sapiens_hsa040240.97887857
79B cell receptor signaling pathway_Homo sapiens_hsa046620.97673862
80Lysosome_Homo sapiens_hsa041420.96733453
81Glycerolipid metabolism_Homo sapiens_hsa005610.93180264
82Ovarian steroidogenesis_Homo sapiens_hsa049130.91420446
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.90575541
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90274848
85Retinol metabolism_Homo sapiens_hsa008300.90081283
86Chemical carcinogenesis_Homo sapiens_hsa052040.89429366
87beta-Alanine metabolism_Homo sapiens_hsa004100.88041206
88Cardiac muscle contraction_Homo sapiens_hsa042600.86520833
89Fatty acid biosynthesis_Homo sapiens_hsa000610.85233934
90Hepatitis C_Homo sapiens_hsa051600.84367916
91Amoebiasis_Homo sapiens_hsa051460.82826127
92Hepatitis B_Homo sapiens_hsa051610.82725401
93Proteasome_Homo sapiens_hsa030500.82132690
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79581427
95Antigen processing and presentation_Homo sapiens_hsa046120.79451701
96Bile secretion_Homo sapiens_hsa049760.75166049
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74704569
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74027209
99Renin secretion_Homo sapiens_hsa049240.72201600
100Lysine degradation_Homo sapiens_hsa003100.72005846
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71173352
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68553472
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68481564
104Amphetamine addiction_Homo sapiens_hsa050310.68416620
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67988629
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67892726
107Histidine metabolism_Homo sapiens_hsa003400.67650138
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67008084
109Basal transcription factors_Homo sapiens_hsa030220.64920220
110Estrogen signaling pathway_Homo sapiens_hsa049150.60632201
111Collecting duct acid secretion_Homo sapiens_hsa049660.58453811
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58183731
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56639897
114Homologous recombination_Homo sapiens_hsa034400.56390954
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56284553
116T cell receptor signaling pathway_Homo sapiens_hsa046600.51895507
117Arginine and proline metabolism_Homo sapiens_hsa003300.51749325
118Other glycan degradation_Homo sapiens_hsa005110.51140756
119Propanoate metabolism_Homo sapiens_hsa006400.50369989
120Epstein-Barr virus infection_Homo sapiens_hsa051690.50081031
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47744970
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.46338387
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45356996
124Ras signaling pathway_Homo sapiens_hsa040140.44974087
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44731816
126Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44132876
127Prolactin signaling pathway_Homo sapiens_hsa049170.43805371
128Synaptic vesicle cycle_Homo sapiens_hsa047210.43742095
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43635265
130Pancreatic secretion_Homo sapiens_hsa049720.43609573
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43422913
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43354647
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.40677664
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.40379464
135Steroid biosynthesis_Homo sapiens_hsa001000.39605596
136Acute myeloid leukemia_Homo sapiens_hsa052210.39392685
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38236816
138Mineral absorption_Homo sapiens_hsa049780.38003993
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.37450255
140Vitamin digestion and absorption_Homo sapiens_hsa049770.36267924
141Fat digestion and absorption_Homo sapiens_hsa049750.36123736
142Axon guidance_Homo sapiens_hsa043600.34899187
143Hedgehog signaling pathway_Homo sapiens_hsa043400.34644504
144Glycosaminoglycan degradation_Homo sapiens_hsa005310.32713346
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.30017220
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28960319
147Sulfur relay system_Homo sapiens_hsa041220.25554993
148Basal cell carcinoma_Homo sapiens_hsa052170.25397694
149Thyroid hormone synthesis_Homo sapiens_hsa049180.24994457
150Choline metabolism in cancer_Homo sapiens_hsa052310.23742758
151HIF-1 signaling pathway_Homo sapiens_hsa040660.23552372
152Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23225426
153Fatty acid degradation_Homo sapiens_hsa000710.22219644
154Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22102392
155Platelet activation_Homo sapiens_hsa046110.21486273
156Purine metabolism_Homo sapiens_hsa002300.20566732
157Peroxisome_Homo sapiens_hsa041460.20387561
158Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20329627
159Complement and coagulation cascades_Homo sapiens_hsa046100.20322372
160Sphingolipid signaling pathway_Homo sapiens_hsa040710.20009008
161Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19376949
162Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16981033
163Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16843142
164Arachidonic acid metabolism_Homo sapiens_hsa005900.15438907
165Type II diabetes mellitus_Homo sapiens_hsa049300.15101840
166Ether lipid metabolism_Homo sapiens_hsa005650.14427444
167Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14366540
168Chronic myeloid leukemia_Homo sapiens_hsa052200.12850323
169HTLV-I infection_Homo sapiens_hsa051660.12695185
170Small cell lung cancer_Homo sapiens_hsa052220.12205384
171Vibrio cholerae infection_Homo sapiens_hsa051100.11517659
172Viral carcinogenesis_Homo sapiens_hsa052030.10929050
173Pentose and glucuronate interconversions_Homo sapiens_hsa000400.10758094
174Sphingolipid metabolism_Homo sapiens_hsa006000.09753069
175Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.08345584
176Dorso-ventral axis formation_Homo sapiens_hsa043200.07724389
177FoxO signaling pathway_Homo sapiens_hsa040680.06536867
178MAPK signaling pathway_Homo sapiens_hsa040100.05302809
179Pancreatic cancer_Homo sapiens_hsa052120.05208752
180Notch signaling pathway_Homo sapiens_hsa043300.02491015
181Regulation of actin cytoskeleton_Homo sapiens_hsa048100.01412012
182p53 signaling pathway_Homo sapiens_hsa041150.01067941
183Insulin resistance_Homo sapiens_hsa04931-0.0562370
184Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0190736

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