TARS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)5.26836380
2establishment of integrated proviral latency (GO:0075713)4.91440174
3tetrahydrofolate metabolic process (GO:0046653)4.17584070
4glycine metabolic process (GO:0006544)4.13204120
5mitotic sister chromatid cohesion (GO:0007064)4.10161300
6DNA unwinding involved in DNA replication (GO:0006268)4.09626527
7nuclear pore organization (GO:0006999)4.01509590
8serine family amino acid biosynthetic process (GO:0009070)3.96635795
9L-serine metabolic process (GO:0006563)3.90041731
10protein localization to kinetochore (GO:0034501)3.90005264
11formation of translation preinitiation complex (GO:0001731)3.89798551
12regulation of centriole replication (GO:0046599)3.84736172
13nucleobase biosynthetic process (GO:0046112)3.80306242
14regulation of translational fidelity (GO:0006450)3.80174446
15IMP biosynthetic process (GO:0006188)3.75372571
16protein complex localization (GO:0031503)3.73669705
17nuclear pore complex assembly (GO:0051292)3.73533244
18CENP-A containing nucleosome assembly (GO:0034080)3.72004716
19double-strand break repair via nonhomologous end joining (GO:0006303)3.70731599
20non-recombinational repair (GO:0000726)3.70731599
21folic acid metabolic process (GO:0046655)3.70391872
22chromatin remodeling at centromere (GO:0031055)3.65423931
23establishment of viral latency (GO:0019043)3.62805682
24cellular protein complex localization (GO:0034629)3.51095941
25mitotic nuclear envelope disassembly (GO:0007077)3.50075853
26DNA replication initiation (GO:0006270)3.49301861
27folic acid-containing compound metabolic process (GO:0006760)3.48338260
28purine nucleobase biosynthetic process (GO:0009113)3.40160903
29regulation of chromosome segregation (GO:0051983)3.38208811
30pteridine-containing compound biosynthetic process (GO:0042559)3.35740497
31one-carbon metabolic process (GO:0006730)3.34473175
32DNA strand elongation involved in DNA replication (GO:0006271)3.31979474
33spindle checkpoint (GO:0031577)3.31959646
34proteasome assembly (GO:0043248)3.31411652
35serine family amino acid metabolic process (GO:0009069)3.26987601
36negative regulation of chromosome segregation (GO:0051985)3.26917949
37IMP metabolic process (GO:0046040)3.26009387
38nucleobase-containing small molecule interconversion (GO:0015949)3.25134833
39ribosome assembly (GO:0042255)3.24243715
40membrane disassembly (GO:0030397)3.22576746
41nuclear envelope disassembly (GO:0051081)3.22576746
42mitotic spindle checkpoint (GO:0071174)3.22373805
43negative regulation of mitotic sister chromatid separation (GO:2000816)3.20325870
44negative regulation of sister chromatid segregation (GO:0033046)3.20325870
45negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.20325870
46negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.20325870
47negative regulation of mitotic sister chromatid segregation (GO:0033048)3.20325870
48mitotic metaphase plate congression (GO:0007080)3.19746362
49regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.16511416
50regulation of mitotic metaphase/anaphase transition (GO:0030071)3.16511416
51DNA replication-dependent nucleosome assembly (GO:0006335)3.13484290
52DNA replication-dependent nucleosome organization (GO:0034723)3.13484290
53DNA replication-independent nucleosome organization (GO:0034724)3.13032762
54DNA replication-independent nucleosome assembly (GO:0006336)3.13032762
55DNA strand elongation (GO:0022616)3.12946682
56viral mRNA export from host cell nucleus (GO:0046784)3.11683403
57histone exchange (GO:0043486)3.11679444
58maturation of SSU-rRNA (GO:0030490)3.08671799
59regulation of mitotic sister chromatid separation (GO:0010965)3.06494424
60regulation of mitotic sister chromatid segregation (GO:0033047)3.06494424
61regulation of sister chromatid segregation (GO:0033045)3.06494424
62ribosome biogenesis (GO:0042254)3.03956401
63mitotic spindle assembly checkpoint (GO:0007094)3.03794410
64nucleotide-excision repair, DNA gap filling (GO:0006297)3.02410338
65chromosome segregation (GO:0007059)3.02378917
66spindle assembly checkpoint (GO:0071173)3.02164316
67regulation of gene silencing by RNA (GO:0060966)3.01574913
68regulation of posttranscriptional gene silencing (GO:0060147)3.01574913
69regulation of gene silencing by miRNA (GO:0060964)3.01574913
70regulation of centrosome cycle (GO:0046605)3.00784467
71protein localization to chromosome, centromeric region (GO:0071459)3.00095170
72DNA topological change (GO:0006265)2.99688696
73pre-miRNA processing (GO:0031054)2.98297479
74DNA ligation (GO:0006266)2.98203676
75proline biosynthetic process (GO:0006561)2.97823217
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.97351246
77negative regulation of fibrinolysis (GO:0051918)2.95950752
78kinetochore organization (GO:0051383)2.95849875
79DNA duplex unwinding (GO:0032508)2.94990404
80DNA geometric change (GO:0032392)2.93634127
81nucleoside salvage (GO:0043174)2.93166526
82regulation of translational elongation (GO:0006448)2.92761844
83DNA conformation change (GO:0071103)2.91940353
84regulation of sister chromatid cohesion (GO:0007063)2.91229852
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90322336
86regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88822194
87pteridine-containing compound metabolic process (GO:0042558)2.86691256
88maturation of 5.8S rRNA (GO:0000460)2.86437333
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85305226
90regulation of translational termination (GO:0006449)2.84792957
91telomere maintenance via semi-conservative replication (GO:0032201)2.83476657
92serine family amino acid catabolic process (GO:0009071)2.81700344
93chaperone-mediated protein complex assembly (GO:0051131)2.81308146
94heterochromatin organization (GO:0070828)2.80516556
95cysteine metabolic process (GO:0006534)2.80097772
96* tRNA aminoacylation for protein translation (GO:0006418)2.79480810
97L-phenylalanine metabolic process (GO:0006558)2.77812875
98erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.77812875
99pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.76745970
100pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.76090174
101UMP metabolic process (GO:0046049)2.76090174
102pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.76090174
103UMP biosynthetic process (GO:0006222)2.76090174
104pore complex assembly (GO:0046931)2.76043737
105metaphase plate congression (GO:0051310)2.75153530
106negative regulation of fatty acid biosynthetic process (GO:0045717)2.73570205
107regulation of spindle organization (GO:0090224)2.72857775
108ribosomal small subunit assembly (GO:0000028)2.71347890
109ribonucleoprotein complex biogenesis (GO:0022613)2.70995626
110mitotic chromosome condensation (GO:0007076)2.68511718
111* amino acid activation (GO:0043038)2.68195865
112* tRNA aminoacylation (GO:0043039)2.68195865
113mitotic sister chromatid segregation (GO:0000070)2.67398114
114homocysteine metabolic process (GO:0050667)2.65881284
115sister chromatid segregation (GO:0000819)2.62041415
116DNA replication checkpoint (GO:0000076)2.61996629
117L-phenylalanine catabolic process (GO:0006559)2.61526889
118erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.61526889
119glyoxylate metabolic process (GO:0046487)2.59665104
120somatic hypermutation of immunoglobulin genes (GO:0016446)2.58391408
121somatic diversification of immune receptors via somatic mutation (GO:0002566)2.58391408
122positive regulation of chromosome segregation (GO:0051984)2.57157555
123regulation of mitotic spindle organization (GO:0060236)2.55076828
124translational initiation (GO:0006413)2.54546356
125mitotic recombination (GO:0006312)2.53973143
126telomere maintenance via recombination (GO:0000722)2.53699577
127sulfur amino acid catabolic process (GO:0000098)2.51235930
128nuclear envelope organization (GO:0006998)2.51201885
129alpha-amino acid biosynthetic process (GO:1901607)2.50615056
130imidazole-containing compound metabolic process (GO:0052803)2.48181532
131translational termination (GO:0006415)2.47916591
132ribosomal large subunit biogenesis (GO:0042273)2.46452325
133regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.45540503
134pyrimidine-containing compound salvage (GO:0008655)2.45451300
135pyrimidine nucleoside salvage (GO:0043097)2.45451300
136kynurenine metabolic process (GO:0070189)2.45134064
137regulation of fibrinolysis (GO:0051917)2.44586500
138telomere maintenance via telomere lengthening (GO:0010833)2.43522357
139viral transcription (GO:0019083)2.43027880
140pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.42293178
141mitochondrial DNA metabolic process (GO:0032042)2.42226945
142paraxial mesoderm development (GO:0048339)2.41888802
143spliceosomal tri-snRNP complex assembly (GO:0000244)2.40002418
144translational elongation (GO:0006414)2.39494216
145sulfur amino acid biosynthetic process (GO:0000097)2.38715970
146aromatic amino acid family catabolic process (GO:0009074)2.38650884
147establishment of chromosome localization (GO:0051303)2.37320413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.32846763
2* MYC_18555785_ChIP-Seq_MESCs_Mouse3.93345305
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.57169815
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41952973
5* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.04826017
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84628345
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70098897
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61459035
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52781229
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37835631
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.23290906
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23129212
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20075947
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.19815180
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18011513
16AR_21909140_ChIP-Seq_LNCAP_Human2.13366753
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.10843178
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.03799592
19XRN2_22483619_ChIP-Seq_HELA_Human1.99898663
20PPARA_22158963_ChIP-Seq_LIVER_Mouse1.97957583
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93794117
22RXR_22158963_ChIP-Seq_LIVER_Mouse1.92416475
23* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.90280540
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85801646
25E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84105078
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76830698
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74981221
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.74744545
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72365615
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69647582
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69462450
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68390842
33DCP1A_22483619_ChIP-Seq_HELA_Human1.67934862
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.67696596
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67296689
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.62999620
37* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62612735
38* E2F1_21310950_ChIP-Seq_MCF-7_Human1.61927497
39* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61792977
40* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59966034
41VDR_23849224_ChIP-Seq_CD4+_Human1.56686798
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55994217
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55037356
44MYC_22102868_ChIP-Seq_BL_Human1.54697591
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52608539
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.51363006
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51095838
48* FOXP3_21729870_ChIP-Seq_TREG_Human1.48654875
49GABP_19822575_ChIP-Seq_HepG2_Human1.48550726
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48217321
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39895346
52KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39895346
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39895346
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39100492
55CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.38980484
56ELK1_19687146_ChIP-ChIP_HELA_Human1.38341441
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38297214
58KDM5A_27292631_Chip-Seq_BREAST_Human1.37083908
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36870977
60TTF2_22483619_ChIP-Seq_HELA_Human1.34037593
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33778290
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29045410
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.27526967
64* LXR_22158963_ChIP-Seq_LIVER_Mouse1.27109903
65TCF3_18692474_ChIP-Seq_MEFs_Mouse1.26174968
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25924107
67TFEB_21752829_ChIP-Seq_HELA_Human1.25484672
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24037094
69* CLOCK_20551151_ChIP-Seq_293T_Human1.22483246
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21846316
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20056541
72* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18734688
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17929328
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16503678
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15989486
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15769102
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15745247
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15482500
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13535148
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13503737
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13235579
82* SOX17_20123909_ChIP-Seq_XEN_Mouse1.11766703
83* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10379168
84CHD1_26751641_Chip-Seq_LNCaP_Human1.07896587
85* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07599253
86MYC_18940864_ChIP-ChIP_HL60_Human1.07502317
87CIITA_25753668_ChIP-Seq_RAJI_Human1.06791666
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05807811
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05659661
90TP63_17297297_ChIP-ChIP_HaCaT_Human1.05512146
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05351628
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05289796
93ZNF263_19887448_ChIP-Seq_K562_Human1.04983553
94RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04703867
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04027880
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03727077
97* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02685338
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02476697
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01942559
100NANOG_16153702_ChIP-ChIP_HESCs_Human1.00263187
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99021488
102* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98768862
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97872383
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97615259
105* ATF3_27146783_Chip-Seq_COLON_Human0.96551748
106OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95506568
107HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94224108
108SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94115183
109NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93756063
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91889060
111SRF_21415370_ChIP-Seq_HL-1_Mouse0.90598644
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90382461
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90359936
114YY1_21170310_ChIP-Seq_MESCs_Mouse0.90337575
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89822146
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89392559
117SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89303541
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89109295
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89095516
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86935432
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86126468
122SOX2_16153702_ChIP-ChIP_HESCs_Human0.85622466
123NANOG_21062744_ChIP-ChIP_HESCs_Human0.82860286
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81264063
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79991837
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75611447

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.15338186
2MP0002139_abnormal_hepatobiliary_system3.58701675
3MP0003693_abnormal_embryo_hatching3.31985620
4MP0003705_abnormal_hypodermis_morpholog3.26002501
5MP0004957_abnormal_blastocyst_morpholog3.07749823
6MP0005360_urolithiasis3.04606596
7MP0010352_gastrointestinal_tract_polyps2.88719366
8MP0005085_abnormal_gallbladder_physiolo2.73417579
9MP0010094_abnormal_chromosome_stability2.59112460
10MP0003111_abnormal_nucleus_morphology2.58579334
11MP0005365_abnormal_bile_salt2.56334388
12MP0003077_abnormal_cell_cycle2.45115357
13MP0008438_abnormal_cutaneous_collagen2.06982844
14MP0008057_abnormal_DNA_replication1.98682421
15MP0001730_embryonic_growth_arrest1.90750008
16MP0004233_abnormal_muscle_weight1.82445502
17MP0008875_abnormal_xenobiotic_pharmacok1.72776080
18MP0003252_abnormal_bile_duct1.70406441
19MP0008007_abnormal_cellular_replicative1.69969184
20MP0010307_abnormal_tumor_latency1.69782119
21MP0009053_abnormal_anal_canal1.69158925
22MP0008932_abnormal_embryonic_tissue1.67366896
23MP0000350_abnormal_cell_proliferation1.66058611
24MP0005023_abnormal_wound_healing1.63089765
25MP0005083_abnormal_biliary_tract1.57610815
26MP0008058_abnormal_DNA_repair1.57324721
27MP0010030_abnormal_orbit_morphology1.55255971
28MP0009840_abnormal_foam_cell1.52381001
29MP0004197_abnormal_fetal_growth/weight/1.49649038
30MP0003566_abnormal_cell_adhesion1.46411497
31MP0005380_embryogenesis_phenotype1.43620135
32MP0001672_abnormal_embryogenesis/_devel1.43620135
33MP0001697_abnormal_embryo_size1.34565331
34MP0005076_abnormal_cell_differentiation1.32969565
35MP0003186_abnormal_redox_activity1.32380927
36MP0003984_embryonic_growth_retardation1.32292312
37MP0010329_abnormal_lipoprotein_level1.32007964
38MP0002088_abnormal_embryonic_growth/wei1.31997501
39MP0002086_abnormal_extraembryonic_tissu1.29848376
40MP0002080_prenatal_lethality1.28798555
41MP0001661_extended_life_span1.25913286
42MP0005623_abnormal_meninges_morphology1.24284142
43MP0000579_abnormal_nail_morphology1.23327205
44MP0003123_paternal_imprinting1.21687797
45MP0001666_abnormal_nutrient_absorption1.21573415
46MP0002084_abnormal_developmental_patter1.19988405
47MP0004272_abnormal_basement_membrane1.19356898
48MP0002085_abnormal_embryonic_tissue1.17646454
49MP0005275_abnormal_skin_tensile1.15898047
50MP0000609_abnormal_liver_physiology1.14645570
51MP0003890_abnormal_embryonic-extraembry1.14581662
52MP0006035_abnormal_mitochondrial_morpho1.14370024
53MP0003718_maternal_effect1.13344432
54MP0000598_abnormal_liver_morphology1.10808864
55MP0003567_abnormal_fetal_cardiomyocyte1.06956499
56MP0003950_abnormal_plasma_membrane1.06934814
57MP0003221_abnormal_cardiomyocyte_apopto1.06396843
58MP0002396_abnormal_hematopoietic_system1.03051947
59MP0006054_spinal_hemorrhage1.02919432
60MP0005319_abnormal_enzyme/_coenzyme1.00247783
61MP0008877_abnormal_DNA_methylation0.99737750
62MP0001243_abnormal_dermal_layer0.98581778
63MP0005332_abnormal_amino_acid0.98174090
64MP0004185_abnormal_adipocyte_glucose0.98131316
65MP0002877_abnormal_melanocyte_morpholog0.97380377
66MP0005220_abnormal_exocrine_pancreas0.96744215
67MP0004264_abnormal_extraembryonic_tissu0.96158172
68MP0002019_abnormal_tumor_incidence0.95646975
69MP0002060_abnormal_skin_morphology0.92395627
70MP0005503_abnormal_tendon_morphology0.91322267
71MP0000490_abnormal_crypts_of0.91224128
72MP0010234_abnormal_vibrissa_follicle0.90860148
73MP0003315_abnormal_perineum_morphology0.89775613
74MP0001286_abnormal_eye_development0.89688653
75MP0001915_intracranial_hemorrhage0.89650376
76MP0009672_abnormal_birth_weight0.89223032
77MP0003786_premature_aging0.89027649
78MP0000537_abnormal_urethra_morphology0.88918384
79MP0002111_abnormal_tail_morphology0.88712387
80MP0002938_white_spotting0.88494074
81MP0000762_abnormal_tongue_morphology0.87978137
82MP0003119_abnormal_digestive_system0.87891959
83MP0002796_impaired_skin_barrier0.86608276
84MP0009697_abnormal_copulation0.86328565
85MP0000313_abnormal_cell_death0.85217111
86MP0001293_anophthalmia0.82826229
87MP0001188_hyperpigmentation0.82143541
88MP0000428_abnormal_craniofacial_morphol0.81199411
89MP0005257_abnormal_intraocular_pressure0.80199866
90MP0002009_preneoplasia0.79670746
91MP0000358_abnormal_cell_content/0.78554020
92MP0004133_heterotaxia0.78348528
93MP0003385_abnormal_body_wall0.73776698
94MP0002697_abnormal_eye_size0.72314990
95MP0000733_abnormal_muscle_development0.72082364
96MP0001764_abnormal_homeostasis0.71352047
97MP0005501_abnormal_skin_physiology0.71313249
98MP0003868_abnormal_feces_composition0.70997653
99MP0005266_abnormal_metabolism0.70649088
100MP0002210_abnormal_sex_determination0.70517829
101MP0002092_abnormal_eye_morphology0.70246695
102MP0003941_abnormal_skin_development0.69750211
103MP0002282_abnormal_trachea_morphology0.67894969
104MP0005408_hypopigmentation0.67876161
105MP0002160_abnormal_reproductive_system0.67874850
106MP0001299_abnormal_eye_distance/0.67677849
107MP0004808_abnormal_hematopoietic_stem0.67526354
108MP0000858_altered_metastatic_potential0.67192633
109MP0000647_abnormal_sebaceous_gland0.67036301
110MP0003453_abnormal_keratinocyte_physiol0.66816206
111MP0000627_abnormal_mammary_gland0.65945510
112MP0003283_abnormal_digestive_organ0.65371377
113MP0001727_abnormal_embryo_implantation0.65138855
114MP0001881_abnormal_mammary_gland0.64755933
115MP0000432_abnormal_head_morphology0.64130773
116MP0000477_abnormal_intestine_morphology0.64090391
117MP0001216_abnormal_epidermal_layer0.63731486
118MP0003195_calcinosis0.62712589
119MP0003115_abnormal_respiratory_system0.62683277
120MP0003943_abnormal_hepatobiliary_system0.61660816
121MP0005395_other_phenotype0.61509450
122MP0002269_muscular_atrophy0.61472866
123MP0001929_abnormal_gametogenesis0.61204049
124MP0002254_reproductive_system_inflammat0.61123281
125MP0005621_abnormal_cell_physiology0.60456500
126MP0008770_decreased_survivor_rate0.60281806
127MP0000377_abnormal_hair_follicle0.60079874
128MP0009703_decreased_birth_body0.59592939
129MP0004019_abnormal_vitamin_homeostasis0.59537083
130MP0009384_cardiac_valve_regurgitation0.59257090
131MP0003755_abnormal_palate_morphology0.58958381
132MP0003656_abnormal_erythrocyte_physiolo0.58787283
133MP0003937_abnormal_limbs/digits/tail_de0.58381824
134MP0005384_cellular_phenotype0.58206386
135MP0010678_abnormal_skin_adnexa0.57373219
136MP0003279_aneurysm0.57167601
137MP0001849_ear_inflammation0.56711605
138MP0003935_abnormal_craniofacial_develop0.56402309

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.00348225
2Chromsome breakage (HP:0040012)4.92558217
3Hypobetalipoproteinemia (HP:0003563)4.43156874
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.19751209
5Intrahepatic cholestasis (HP:0001406)4.12861097
6Deep venous thrombosis (HP:0002625)3.52513477
7Abnormality of pyrimidine metabolism (HP:0004353)3.46313106
8Protrusio acetabuli (HP:0003179)3.28286796
9Abnormality of chromosome stability (HP:0003220)3.23102204
10Abnormality of the preputium (HP:0100587)3.14836674
11Abnormality of glycolysis (HP:0004366)3.08608381
12Increased nuchal translucency (HP:0010880)3.06782121
13Spastic diplegia (HP:0001264)3.01832442
14Meckel diverticulum (HP:0002245)2.97812696
15Hypolipoproteinemia (HP:0010981)2.96476976
16Nephroblastoma (Wilms tumor) (HP:0002667)2.94851828
17Abnormality of aromatic amino acid family metabolism (HP:0004338)2.93623402
18Ependymoma (HP:0002888)2.93475913
19Xanthomatosis (HP:0000991)2.93146255
20Abnormality of sulfur amino acid metabolism (HP:0004339)2.90149318
21Abnormality of the ileum (HP:0001549)2.82865960
22Increased serum pyruvate (HP:0003542)2.78077653
23Embryonal renal neoplasm (HP:0011794)2.76603871
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.75723157
25Abnormality of methionine metabolism (HP:0010901)2.74643959
26Multiple enchondromatosis (HP:0005701)2.72776792
27Microvesicular hepatic steatosis (HP:0001414)2.66563410
28Duodenal stenosis (HP:0100867)2.63787759
29Small intestinal stenosis (HP:0012848)2.63787759
30Hyperglycinemia (HP:0002154)2.62387275
31Myelodysplasia (HP:0002863)2.55012530
32Abnormal lung lobation (HP:0002101)2.54257655
33Colon cancer (HP:0003003)2.53113956
34Selective tooth agenesis (HP:0001592)2.51881870
35Abnormal cartilage morphology (HP:0002763)2.50873736
36Premature rupture of membranes (HP:0001788)2.42622515
37Degeneration of anterior horn cells (HP:0002398)2.40683757
38Abnormality of the anterior horn cell (HP:0006802)2.40683757
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.39831070
40Birth length less than 3rd percentile (HP:0003561)2.37184912
41Abnormality of the common coagulation pathway (HP:0010990)2.36688545
42Upper limb muscle weakness (HP:0003484)2.35899416
43Oral leukoplakia (HP:0002745)2.35670151
44Back pain (HP:0003418)2.32510014
45Trismus (HP:0000211)2.30265699
46Breast hypoplasia (HP:0003187)2.29957234
47Hyperammonemia (HP:0001987)2.28487358
48Progressive muscle weakness (HP:0003323)2.28044502
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.27429773
50Abnormality of serine family amino acid metabolism (HP:0010894)2.26650842
51Abnormality of glycine metabolism (HP:0010895)2.26650842
52Abnormality of the intrinsic pathway (HP:0010989)2.25382539
53Overlapping toe (HP:0001845)2.24935604
54Rhabdomyosarcoma (HP:0002859)2.23342615
55Prolonged partial thromboplastin time (HP:0003645)2.23341834
56Fat malabsorption (HP:0002630)2.22478444
57Abnormality of the carotid arteries (HP:0005344)2.19126384
58Entropion (HP:0000621)2.18902232
59Volvulus (HP:0002580)2.16951146
60Abnormality of the duodenum (HP:0002246)2.14733971
61Hyperglycinuria (HP:0003108)2.11609730
62Ankle contracture (HP:0006466)2.11327378
63Hepatocellular carcinoma (HP:0001402)2.08313194
64Abnormality of the calcaneus (HP:0008364)2.08311129
65Cafe-au-lait spot (HP:0000957)2.07346350
66Medulloblastoma (HP:0002885)2.06866122
67Reticulocytopenia (HP:0001896)2.05729167
68Abnormality of the umbilical cord (HP:0010881)2.05584479
69Horseshoe kidney (HP:0000085)2.04559469
70Abnormality of the labia minora (HP:0012880)2.04038513
71Hypoglycemic coma (HP:0001325)2.03912180
72Hypoalphalipoproteinemia (HP:0003233)2.03717895
73Breech presentation (HP:0001623)2.03708539
74Deviation of the thumb (HP:0009603)2.03653031
75Abnormality of serum amino acid levels (HP:0003112)2.03306834
76Cortical dysplasia (HP:0002539)2.03232151
77Deep philtrum (HP:0002002)2.03225389
78Complement deficiency (HP:0004431)2.00171151
79Progressive external ophthalmoplegia (HP:0000590)2.00058281
80Acute myeloid leukemia (HP:0004808)1.98577837
81Missing ribs (HP:0000921)1.97437437
82Increased mean platelet volume (HP:0011877)1.97230387
83Astrocytoma (HP:0009592)1.96064743
84Abnormality of the astrocytes (HP:0100707)1.96064743
85Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95559786
86Abnormality of homocysteine metabolism (HP:0010919)1.95106325
87Homocystinuria (HP:0002156)1.95106325
88Neoplasm of the colon (HP:0100273)1.94114310
89Biliary tract neoplasm (HP:0100574)1.93458415
90Epidermoid cyst (HP:0200040)1.92018871
91Choanal atresia (HP:0000453)1.91999054
92Proximal placement of thumb (HP:0009623)1.91374899
93Ankyloglossia (HP:0010296)1.90484305
94Facial cleft (HP:0002006)1.89819341
95Biconcave vertebral bodies (HP:0004586)1.89818471
96Hypochromic microcytic anemia (HP:0004840)1.89331034
97Aplasia involving forearm bones (HP:0009822)1.88599512
98Absent forearm bone (HP:0003953)1.88599512
99Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88031055
100Abnormal number of incisors (HP:0011064)1.87960431
101Poikiloderma (HP:0001029)1.86951925
102Sloping forehead (HP:0000340)1.86631249
103Abnormality of complement system (HP:0005339)1.86604626
104Cutaneous melanoma (HP:0012056)1.86196582
105Megaloblastic anemia (HP:0001889)1.85734050
106Pseudobulbar signs (HP:0002200)1.85471553
107Abnormalities of placenta or umbilical cord (HP:0001194)1.85254473
108Abnormality of nucleobase metabolism (HP:0010932)1.83427379
109Nonimmune hydrops fetalis (HP:0001790)1.82363553
110Metaphyseal cupping (HP:0003021)1.81987125
111Abnormal delivery (HP:0001787)1.81840038
112Carpal bone hypoplasia (HP:0001498)1.79748377
113Adenoma sebaceum (HP:0009720)1.77684422
114Angiofibromas (HP:0010615)1.77684422
115Aplastic anemia (HP:0001915)1.77606247
116Squamous cell carcinoma (HP:0002860)1.76831878
117Cervical subluxation (HP:0003308)1.76429995
118Septate vagina (HP:0001153)1.76197637
119Termporal pattern (HP:0011008)1.75233974
120Insidious onset (HP:0003587)1.75233974
121Secondary amenorrhea (HP:0000869)1.74756004
122Short middle phalanx of the 5th finger (HP:0004220)1.74736450
123Myocardial infarction (HP:0001658)1.73828389
124Postnatal microcephaly (HP:0005484)1.72593411
125Neoplasm of the pancreas (HP:0002894)1.72485024
126Thrombocytosis (HP:0001894)1.72444800
127Peritonitis (HP:0002586)1.72233433
128Aplasia/hypoplasia of the humerus (HP:0006507)1.72121365
129Microglossia (HP:0000171)1.72013247
130Agnosia (HP:0010524)1.71699751
131Steatorrhea (HP:0002570)1.71642592
132Abnormal gallbladder physiology (HP:0012438)1.71564542
133Cholecystitis (HP:0001082)1.71564542
134Abnormal hemoglobin (HP:0011902)1.69977794
135Ulnar bowing (HP:0003031)1.69126699
136Abnormal platelet volume (HP:0011876)1.67193232
137Ectopic kidney (HP:0000086)1.66695942
138Microretrognathia (HP:0000308)1.66239370
139Impulsivity (HP:0100710)1.66131361
140Calcaneovalgus deformity (HP:0001848)1.65590445
141Absent radius (HP:0003974)1.64607513
142Abnormality of reticulocytes (HP:0004312)1.64228906
143Embryonal neoplasm (HP:0002898)1.64148987
144Abnormal biliary tract morphology (HP:0012440)1.64067207
145Insomnia (HP:0100785)1.63178406
146Abnormality of cochlea (HP:0000375)1.62942257
147Atresia of the external auditory canal (HP:0000413)1.62661192
148Patellar aplasia (HP:0006443)1.61974392
149Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61843874
150Abnormality of alanine metabolism (HP:0010916)1.61843874
151Hyperalaninemia (HP:0003348)1.61843874
152Basal cell carcinoma (HP:0002671)1.61821069
153Glioma (HP:0009733)1.60594976
154Abnormal umbilical cord blood vessels (HP:0011403)1.60577069
155Single umbilical artery (HP:0001195)1.60577069
156Abnormality of the fetal cardiovascular system (HP:0010948)1.60577069
157Hyperlipoproteinemia (HP:0010980)1.60348668
158Vertebral compression fractures (HP:0002953)1.60044922
159Hyperbilirubinemia (HP:0002904)1.59957597
160Skin nodule (HP:0200036)1.59608889
161Arteriovenous malformation (HP:0100026)1.58998183
162Short humerus (HP:0005792)1.58793267
16311 pairs of ribs (HP:0000878)1.58625921
164Abnormality of oral frenula (HP:0000190)1.58444490
165Sparse lateral eyebrow (HP:0005338)1.58388645
166Cerebral edema (HP:0002181)1.57267069
167Increased density of long bones (HP:0006392)1.55663799
168Glossoptosis (HP:0000162)1.55552275
169Esophageal varix (HP:0002040)1.53989559
170Macrocytic anemia (HP:0001972)1.53677182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.09278472
2BUB13.07677897
3WEE12.93772922
4EPHA22.68879308
5EIF2AK12.53126097
6NEK12.51917358
7PKN22.24052196
8RPS6KB22.22067809
9BCKDK2.12577974
10TTK2.10478451
11CDK122.09534976
12PDK22.09364684
13EEF2K2.05999552
14TSSK62.05639629
15NEK22.01801293
16MST1R1.95107528
17MST41.90713731
18PASK1.86424279
19FLT31.71384087
20MAP3K101.67057625
21BRSK21.65359214
22STK101.60451415
23RPS6KA41.59770940
24NME21.59313291
25VRK21.59161893
26LATS11.55097509
27SCYL21.52989894
28PLK11.50152950
29TESK21.49032471
30ERN11.49010269
31SMG11.48573014
32MAP3K81.48517252
33TRIB31.47266303
34CDK71.45283882
35AURKB1.44449779
36TAF11.43443872
37EIF2AK31.41369622
38PAK41.40218705
39SRPK11.39528451
40CDK41.29218231
41TTN1.28585614
42PLK31.25797413
43ACVR1B1.23824582
44SIK11.22137487
45PNCK1.19468923
46ATR1.19209234
47LATS21.19022028
48CDK61.13563256
49STK38L1.13418213
50LRRK21.08208773
51TGFBR11.07098992
52TRIM281.06788196
53NME11.06702217
54CHEK11.04360885
55PLK41.02639739
56AURKA0.99294200
57MKNK10.98591525
58EIF2AK20.98196176
59MET0.94834571
60STK30.94637955
61MTOR0.92933800
62TESK10.92336312
63DDR20.91121364
64ALK0.88676575
65CLK10.86769470
66PAK20.84538088
67ERBB40.84456550
68STK40.83770844
69CHEK20.83751575
70BRSK10.83744992
71PDGFRA0.83073257
72FGFR40.82723358
73TLK10.81355131
74PTK60.80735376
75MAP3K30.79081632
76FGFR10.78357863
77IRAK30.78198969
78DYRK30.78147206
79NEK90.77632084
80PIM10.77437159
81NUAK10.77198509
82BRAF0.74798186
83CDK20.72269877
84BMX0.71864667
85MAP2K30.70442126
86MAP3K120.70440363
87MAPKAPK30.68412501
88MAP3K110.68288384
89ATM0.68269643
90MELK0.67021708
91CSNK2A20.62108026
92KDR0.61697030
93TNIK0.60959312
94TAOK20.60834391
95ERBB30.59209765
96CDK80.57211769
97PAK10.57139653
98MAPK110.56758910
99ZAK0.56429963
100PRKCI0.55788702
101PTK20.54648117
102CSNK2A10.52101092
103BCR0.51129134
104PBK0.50941405
105ICK0.50423922
106FRK0.49880321
107CDK10.47694053
108VRK10.45922607
109CCNB10.45609870
110BRD40.44609103
111MAPKAPK50.44439874
112DAPK10.43631739
113CSNK1E0.42860460
114AKT20.42527802
115PRKDC0.41576430
116ZAP700.41240027
117CHUK0.39062538
118JAK30.38660400
119ABL20.37027393
120RAF10.36911740
121CAMK1G0.36273331
122AKT30.32223983
123TRPM70.32221567
124STK160.32014584
125MKNK20.31697034
126PIM20.31428060
127PLK20.30900224
128STK240.29168852
129MAPK140.27804828
130NEK60.26605678
131CSNK1G10.26193518
132CDK90.26041920
133CDK180.23006609

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.49104215
2DNA replication_Homo sapiens_hsa030302.92192442
3Mismatch repair_Homo sapiens_hsa034302.65603573
4* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.55217941
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38090082
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.29284137
7Selenocompound metabolism_Homo sapiens_hsa004502.27863911
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.22638969
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.15735356
10RNA transport_Homo sapiens_hsa030132.15408556
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.11474731
12Drug metabolism - other enzymes_Homo sapiens_hsa009832.03327497
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.99160356
14Spliceosome_Homo sapiens_hsa030401.90366782
15Proteasome_Homo sapiens_hsa030501.88599945
16Biosynthesis of amino acids_Homo sapiens_hsa012301.86238025
17Ribosome_Homo sapiens_hsa030101.72806988
18Nucleotide excision repair_Homo sapiens_hsa034201.71917113
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68842412
20Base excision repair_Homo sapiens_hsa034101.68064824
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.60957204
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.59413726
23Arginine biosynthesis_Homo sapiens_hsa002201.58357240
24Cell cycle_Homo sapiens_hsa041101.54996300
25Pyrimidine metabolism_Homo sapiens_hsa002401.46444849
26Protein export_Homo sapiens_hsa030601.46143873
27Nitrogen metabolism_Homo sapiens_hsa009101.42133823
28Carbon metabolism_Homo sapiens_hsa012001.38163924
29Tryptophan metabolism_Homo sapiens_hsa003801.37547437
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36176793
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33846583
32Homologous recombination_Homo sapiens_hsa034401.33490800
33RNA polymerase_Homo sapiens_hsa030201.33306325
34Folate biosynthesis_Homo sapiens_hsa007901.31941421
35Complement and coagulation cascades_Homo sapiens_hsa046101.31922110
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23076795
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21079630
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20096931
39Fatty acid degradation_Homo sapiens_hsa000711.19159775
40p53 signaling pathway_Homo sapiens_hsa041151.07974621
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06006653
42Non-homologous end-joining_Homo sapiens_hsa034501.04973630
43Chemical carcinogenesis_Homo sapiens_hsa052041.04438832
44Pentose phosphate pathway_Homo sapiens_hsa000301.03412953
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99403518
46Vitamin B6 metabolism_Homo sapiens_hsa007500.99082442
47Sulfur relay system_Homo sapiens_hsa041220.95877478
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95522148
49Pyruvate metabolism_Homo sapiens_hsa006200.95520378
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95469361
51RNA degradation_Homo sapiens_hsa030180.94906852
52Systemic lupus erythematosus_Homo sapiens_hsa053220.91899391
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90076613
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89665255
55mRNA surveillance pathway_Homo sapiens_hsa030150.89559430
56Retinol metabolism_Homo sapiens_hsa008300.89395179
57Oocyte meiosis_Homo sapiens_hsa041140.88539420
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88320682
59Fanconi anemia pathway_Homo sapiens_hsa034600.87529993
60Glutathione metabolism_Homo sapiens_hsa004800.87173879
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86529046
62Peroxisome_Homo sapiens_hsa041460.84576346
63Phenylalanine metabolism_Homo sapiens_hsa003600.84491235
64Propanoate metabolism_Homo sapiens_hsa006400.82701030
65Arginine and proline metabolism_Homo sapiens_hsa003300.82161261
66Fat digestion and absorption_Homo sapiens_hsa049750.81405202
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79228169
68N-Glycan biosynthesis_Homo sapiens_hsa005100.78173173
69Starch and sucrose metabolism_Homo sapiens_hsa005000.75254069
70Tyrosine metabolism_Homo sapiens_hsa003500.74540025
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.74208048
72Caffeine metabolism_Homo sapiens_hsa002320.73382489
73Fatty acid elongation_Homo sapiens_hsa000620.72744980
74Adherens junction_Homo sapiens_hsa045200.70880892
75Lysine degradation_Homo sapiens_hsa003100.68150532
76Butanoate metabolism_Homo sapiens_hsa006500.66340630
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.66324364
78Viral carcinogenesis_Homo sapiens_hsa052030.66268253
79PPAR signaling pathway_Homo sapiens_hsa033200.65639719
80Galactose metabolism_Homo sapiens_hsa000520.64408768
81beta-Alanine metabolism_Homo sapiens_hsa004100.64361267
82Fatty acid metabolism_Homo sapiens_hsa012120.63110715
83Fructose and mannose metabolism_Homo sapiens_hsa000510.59621109
84Bladder cancer_Homo sapiens_hsa052190.58155740
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58029065
86Steroid biosynthesis_Homo sapiens_hsa001000.57502295
87Histidine metabolism_Homo sapiens_hsa003400.55994100
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55354826
89Epstein-Barr virus infection_Homo sapiens_hsa051690.52934622
90Hippo signaling pathway_Homo sapiens_hsa043900.52482690
91Small cell lung cancer_Homo sapiens_hsa052220.52208504
92Antigen processing and presentation_Homo sapiens_hsa046120.52071987
93Staphylococcus aureus infection_Homo sapiens_hsa051500.51043018
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49641730
95Legionellosis_Homo sapiens_hsa051340.47310435
96Huntingtons disease_Homo sapiens_hsa050160.47031482
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.44312341
98MicroRNAs in cancer_Homo sapiens_hsa052060.44285239
99Basal transcription factors_Homo sapiens_hsa030220.43378390
100Parkinsons disease_Homo sapiens_hsa050120.39666477
101Thyroid cancer_Homo sapiens_hsa052160.38255089
102Purine metabolism_Homo sapiens_hsa002300.37779686
103Sulfur metabolism_Homo sapiens_hsa009200.37102200
104HTLV-I infection_Homo sapiens_hsa051660.35089357
105TGF-beta signaling pathway_Homo sapiens_hsa043500.34915773
106Alcoholism_Homo sapiens_hsa050340.34453361
107Prostate cancer_Homo sapiens_hsa052150.33377180
108Chronic myeloid leukemia_Homo sapiens_hsa052200.33133036
109Metabolic pathways_Homo sapiens_hsa011000.32929218
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32548375
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32026285
112Vitamin digestion and absorption_Homo sapiens_hsa049770.30083011
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29933177
114Herpes simplex infection_Homo sapiens_hsa051680.29758935
115Tight junction_Homo sapiens_hsa045300.29150160
116Proteoglycans in cancer_Homo sapiens_hsa052050.25137615
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22152882
118Colorectal cancer_Homo sapiens_hsa052100.21651958
119Pancreatic cancer_Homo sapiens_hsa052120.20863969
120Wnt signaling pathway_Homo sapiens_hsa043100.20234280
121Oxidative phosphorylation_Homo sapiens_hsa001900.18884278
122Melanoma_Homo sapiens_hsa052180.18344401
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18133593
124Shigellosis_Homo sapiens_hsa051310.14943382
125Basal cell carcinoma_Homo sapiens_hsa052170.14432230
126Apoptosis_Homo sapiens_hsa042100.13689949
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12790953

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