TARS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.00965307
2maturation of SSU-rRNA (GO:0030490)4.74974622
3DNA strand elongation involved in DNA replication (GO:0006271)4.66314077
4DNA replication initiation (GO:0006270)4.60367539
5DNA deamination (GO:0045006)4.49013768
6DNA strand elongation (GO:0022616)4.45921046
7DNA unwinding involved in DNA replication (GO:0006268)4.44365651
8telomere maintenance via semi-conservative replication (GO:0032201)4.36072740
9viral transcription (GO:0019083)4.34184812
10nucleobase biosynthetic process (GO:0046112)4.33217348
11translational termination (GO:0006415)4.24815797
12regulation of mitochondrial translation (GO:0070129)4.24706474
13ribosomal small subunit biogenesis (GO:0042274)4.20341264
14folic acid-containing compound biosynthetic process (GO:0009396)4.16677981
15translational elongation (GO:0006414)4.04126265
16purine nucleobase biosynthetic process (GO:0009113)4.03320183
17IMP biosynthetic process (GO:0006188)4.00025905
18DNA replication checkpoint (GO:0000076)3.84393762
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.83851484
20telomere maintenance via recombination (GO:0000722)3.82941088
21formation of translation preinitiation complex (GO:0001731)3.77296452
22base-excision repair, AP site formation (GO:0006285)3.68132631
23ATP synthesis coupled proton transport (GO:0015986)3.67690457
24energy coupled proton transport, down electrochemical gradient (GO:0015985)3.67690457
25ribosomal large subunit biogenesis (GO:0042273)3.65280946
26ribonucleoprotein complex biogenesis (GO:0022613)3.65049492
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.63315474
28branched-chain amino acid catabolic process (GO:0009083)3.62923390
29mitotic recombination (GO:0006312)3.59974879
30translational initiation (GO:0006413)3.59514261
31telomere maintenance via telomere lengthening (GO:0010833)3.57215718
32peptidyl-histidine modification (GO:0018202)3.56180030
33protein-cofactor linkage (GO:0018065)3.54421558
34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.53391071
35mitochondrial respiratory chain complex assembly (GO:0033108)3.53240890
36IMP metabolic process (GO:0046040)3.52706194
37protein complex biogenesis (GO:0070271)3.52113535
38cotranslational protein targeting to membrane (GO:0006613)3.50821759
39ribosome biogenesis (GO:0042254)3.50774513
40protein targeting to ER (GO:0045047)3.49492164
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.44810051
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.42716613
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.42716613
44rRNA processing (GO:0006364)3.41846599
45ubiquinone biosynthetic process (GO:0006744)3.41235274
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.41064971
47nuclear pore organization (GO:0006999)3.40542853
48mitotic nuclear envelope disassembly (GO:0007077)3.39028311
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35184990
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.35184990
51NADH dehydrogenase complex assembly (GO:0010257)3.35184990
52pseudouridine synthesis (GO:0001522)3.33764912
53folic acid metabolic process (GO:0046655)3.33079602
54establishment of protein localization to mitochondrial membrane (GO:0090151)3.33040873
55establishment of protein localization to endoplasmic reticulum (GO:0072599)3.31127894
56chromatin remodeling at centromere (GO:0031055)3.29904613
57rRNA metabolic process (GO:0016072)3.29018875
58CENP-A containing nucleosome assembly (GO:0034080)3.28285960
59cellular protein complex disassembly (GO:0043624)3.28190439
60protein localization to endoplasmic reticulum (GO:0070972)3.26044172
61regulation of translational fidelity (GO:0006450)3.25391190
62electron transport chain (GO:0022900)3.23513299
63viral life cycle (GO:0019058)3.22978976
64protein deneddylation (GO:0000338)3.21666347
65respiratory electron transport chain (GO:0022904)3.21151753
66cullin deneddylation (GO:0010388)3.20164598
67maturation of 5.8S rRNA (GO:0000460)3.20129900
68* tRNA metabolic process (GO:0006399)3.19478013
69nucleotide-excision repair, DNA gap filling (GO:0006297)3.13111652
70proteasome assembly (GO:0043248)3.12951037
71mitotic metaphase plate congression (GO:0007080)3.12891656
72tRNA processing (GO:0008033)3.12833340
73DNA duplex unwinding (GO:0032508)3.10791113
74somatic hypermutation of immunoglobulin genes (GO:0016446)3.10611248
75somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10611248
76tetrahydrofolate metabolic process (GO:0046653)3.10224493
77ubiquinone metabolic process (GO:0006743)3.09810305
78DNA geometric change (GO:0032392)3.09255747
79chaperone-mediated protein transport (GO:0072321)3.08866457
80regulation of nuclear cell cycle DNA replication (GO:0033262)3.07920429
81nuclear envelope disassembly (GO:0051081)3.07782937
82membrane disassembly (GO:0030397)3.07782937
83nuclear pore complex assembly (GO:0051292)3.07661614
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.07325697
85spliceosomal snRNP assembly (GO:0000387)3.06260189
86DNA double-strand break processing (GO:0000729)3.05765024
87ribosome assembly (GO:0042255)3.04949395
88iron-sulfur cluster assembly (GO:0016226)3.04732269
89metallo-sulfur cluster assembly (GO:0031163)3.04732269
90tRNA methylation (GO:0030488)3.04387173
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03543922
92protein localization to kinetochore (GO:0034501)3.02811476
93branched-chain amino acid metabolic process (GO:0009081)3.01095511
94cytochrome complex assembly (GO:0017004)3.00241091
95water-soluble vitamin biosynthetic process (GO:0042364)2.99824022
96translation (GO:0006412)2.99117923
97deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.98295029
98signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.98101335
99signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.98101335
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.98101335
101protein complex disassembly (GO:0043241)2.97343004
102kinetochore organization (GO:0051383)2.97265923
103regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96955569
104replication fork processing (GO:0031297)2.96663323
105UTP biosynthetic process (GO:0006228)2.95873085
106rRNA methylation (GO:0031167)2.95446318
107* tRNA aminoacylation for protein translation (GO:0006418)2.95413028
108DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.94498824
109negative regulation of ligase activity (GO:0051352)2.94405409
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94405409
111telomere organization (GO:0032200)2.93933607
112telomere maintenance (GO:0000723)2.93422467
113respiratory chain complex IV assembly (GO:0008535)2.93273163
114metaphase plate congression (GO:0051310)2.93085424
115signal transduction involved in DNA damage checkpoint (GO:0072422)2.92792378
116signal transduction involved in DNA integrity checkpoint (GO:0072401)2.92792378
117DNA replication-independent nucleosome organization (GO:0034724)2.92763181
118DNA replication-independent nucleosome assembly (GO:0006336)2.92763181
119signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91631921
120intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91631921
121pyrimidine nucleotide catabolic process (GO:0006244)2.91337400
122protein targeting to mitochondrion (GO:0006626)2.91022434
123regulation of cellular amino acid metabolic process (GO:0006521)2.90825711
124signal transduction involved in cell cycle checkpoint (GO:0072395)2.90534846
125nuclear-transcribed mRNA catabolic process (GO:0000956)2.90427538
126rRNA modification (GO:0000154)2.89999241
127mannosylation (GO:0097502)2.89948805
128oxidative phosphorylation (GO:0006119)2.89947128
129inner mitochondrial membrane organization (GO:0007007)2.89455469
130transcription-coupled nucleotide-excision repair (GO:0006283)2.89405284
131DNA replication-dependent nucleosome organization (GO:0034723)2.89220849
132DNA replication-dependent nucleosome assembly (GO:0006335)2.89220849
133GTP biosynthetic process (GO:0006183)2.88922940
134anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88890345
135* tRNA aminoacylation (GO:0043039)2.88214125
136* amino acid activation (GO:0043038)2.88214125
137pteridine-containing compound biosynthetic process (GO:0042559)2.86398274
138regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.85723702
139macromolecular complex disassembly (GO:0032984)2.83346460
140ncRNA processing (GO:0034470)2.82788873
141kinetochore assembly (GO:0051382)2.82415865
142* mitochondrial RNA metabolic process (GO:0000959)2.82339717
143mismatch repair (GO:0006298)2.82233376
144DNA catabolic process, exonucleolytic (GO:0000738)2.80854033
145L-serine metabolic process (GO:0006563)2.79555094
146cellular component biogenesis (GO:0044085)2.79306427
147RNA catabolic process (GO:0006401)2.77503220
148mRNA catabolic process (GO:0006402)2.77414564
149nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77278219
150regulation of histone H3-K9 methylation (GO:0051570)2.77121803
151folic acid-containing compound metabolic process (GO:0006760)2.75399302
152establishment of protein localization to mitochondrion (GO:0072655)2.74820791
153serine family amino acid biosynthetic process (GO:0009070)2.74653620
154* ncRNA metabolic process (GO:0034660)2.74194422
155pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.74050210
156regulation of gene silencing by RNA (GO:0060966)2.73354250
157regulation of posttranscriptional gene silencing (GO:0060147)2.73354250
158regulation of gene silencing by miRNA (GO:0060964)2.73354250
159histone H2A acetylation (GO:0043968)2.72259740
160viral mRNA export from host cell nucleus (GO:0046784)2.71601600
161mitochondrial DNA replication (GO:0006264)2.70296826
162tRNA modification (GO:0006400)2.69007838
163negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.68043550
164establishment of chromosome localization (GO:0051303)2.66894466
165translesion synthesis (GO:0019985)2.66685921
166protein localization to chromosome, centromeric region (GO:0071459)2.65447159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.76715757
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.14917177
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72708872
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07479260
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.86000000
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84521443
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82297896
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81625475
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.80669042
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79078465
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.71600247
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67013807
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.58545628
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58413204
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54445621
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43278948
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26535504
18* XRN2_22483619_ChIP-Seq_HELA_Human2.19121817
19* VDR_23849224_ChIP-Seq_CD4+_Human2.16498107
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14155575
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14060532
22* FOXP3_21729870_ChIP-Seq_TREG_Human2.05872376
23* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03940534
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96612080
25CIITA_25753668_ChIP-Seq_RAJI_Human1.95718879
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94510338
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94282864
28MYC_22102868_ChIP-Seq_BL_Human1.93666497
29DCP1A_22483619_ChIP-Seq_HELA_Human1.87811050
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83023749
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81462076
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74758430
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.73493604
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71942462
35GABP_19822575_ChIP-Seq_HepG2_Human1.70704782
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70001269
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.67900809
38* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67860744
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66286389
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64750251
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.64443873
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63989185
43TTF2_22483619_ChIP-Seq_HELA_Human1.63651509
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.59297189
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57309316
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56543064
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55751978
48ZNF274_21170338_ChIP-Seq_K562_Hela1.54656620
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54583312
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51951519
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48633456
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48480454
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47424212
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.47072997
55AR_21909140_ChIP-Seq_LNCAP_Human1.45370319
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44058268
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42276956
58VDR_21846776_ChIP-Seq_THP-1_Human1.40137108
59ELK1_19687146_ChIP-ChIP_HELA_Human1.38578434
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37981410
61KDM5A_27292631_Chip-Seq_BREAST_Human1.35036401
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33317096
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29902142
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26082468
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23552932
66* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23494399
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23313282
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22141238
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22071528
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20154600
71SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18788011
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17506135
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15587001
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15354663
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14452536
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08596902
77SPI1_23547873_ChIP-Seq_NB4_Human1.07863586
78TFEB_21752829_ChIP-Seq_HELA_Human1.07378243
79IRF1_19129219_ChIP-ChIP_H3396_Human1.06722530
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06512289
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06431367
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06065872
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05651303
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05143854
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04958896
86* FOXP1_21924763_ChIP-Seq_HESCs_Human1.03913097
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03273711
88IRF8_22096565_ChIP-ChIP_GC-B_Human1.00890210
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00450565
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99636802
91SCL_19346495_ChIP-Seq_HPC-7_Human0.98237503
92VDR_22108803_ChIP-Seq_LS180_Human0.98059562
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96877464
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93840688
95EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93596259
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90183407
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89809469
98STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89566088
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88928387
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85998087
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85899340
102MYC_18940864_ChIP-ChIP_HL60_Human0.85549690
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85458028
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85166014
105* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85061201
106MAF_26560356_Chip-Seq_TH1_Human0.84756199
107CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84638345
108TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84337143
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83521501
110MYB_26560356_Chip-Seq_TH1_Human0.83115872
111YY1_22570637_ChIP-Seq_MALME-3M_Human0.82852219
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.82817803
113MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82377284
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82341294
115SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82293651
116RUNX1_22412390_ChIP-Seq_EML_Mouse0.81412162
117* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81379276
118CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80660405
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79703059
120RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.78939066
121ELF1_20517297_ChIP-Seq_JURKAT_Human0.78296251
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75384120
123* TP53_22573176_ChIP-Seq_HFKS_Human0.74128201
124CTCF_26484167_Chip-Seq_Bcells_Mouse0.73889700
125ERA_21632823_ChIP-Seq_H3396_Human0.71026518

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.67931751
2MP0010094_abnormal_chromosome_stability4.34370313
3MP0003111_abnormal_nucleus_morphology4.02694792
4MP0003806_abnormal_nucleotide_metabolis3.60774375
5MP0008057_abnormal_DNA_replication3.56713876
6MP0003077_abnormal_cell_cycle3.46213388
7MP0008058_abnormal_DNA_repair3.45997645
8MP0004957_abnormal_blastocyst_morpholog3.44245902
9MP0002396_abnormal_hematopoietic_system3.34202357
10MP0008007_abnormal_cellular_replicative2.43876870
11MP0006292_abnormal_olfactory_placode2.31530740
12MP0003763_abnormal_thymus_physiology2.31230189
13MP0000372_irregular_coat_pigmentation2.28416507
14MP0000490_abnormal_crypts_of2.02087574
15MP0003786_premature_aging1.97752158
16MP0008877_abnormal_DNA_methylation1.95858320
17MP0001529_abnormal_vocalization1.89881785
18MP0004145_abnormal_muscle_electrophysio1.78841058
19MP0001730_embryonic_growth_arrest1.78466730
20MP0009333_abnormal_splenocyte_physiolog1.73579230
21MP0008995_early_reproductive_senescence1.73530704
22MP0005645_abnormal_hypothalamus_physiol1.71719274
23MP0004808_abnormal_hematopoietic_stem1.71611953
24MP0002398_abnormal_bone_marrow1.69248511
25MP0002837_dystrophic_cardiac_calcinosis1.68522598
26MP0002722_abnormal_immune_system1.62748653
27MP0000350_abnormal_cell_proliferation1.62535361
28MP0000689_abnormal_spleen_morphology1.62147089
29MP0003136_yellow_coat_color1.61015137
30MP0003186_abnormal_redox_activity1.58616955
31MP0001853_heart_inflammation1.58611363
32MP0008932_abnormal_embryonic_tissue1.58250126
33MP0002163_abnormal_gland_morphology1.56867799
34MP0006036_abnormal_mitochondrial_physio1.55622187
35MP0000703_abnormal_thymus_morphology1.53757862
36MP0002019_abnormal_tumor_incidence1.51595847
37MP0001835_abnormal_antigen_presentation1.51403609
38MP0002102_abnormal_ear_morphology1.50792466
39MP0009840_abnormal_foam_cell1.49732595
40MP0008875_abnormal_xenobiotic_pharmacok1.48565331
41MP0001545_abnormal_hematopoietic_system1.48519627
42MP0005397_hematopoietic_system_phenotyp1.48519627
43MP0001800_abnormal_humoral_immune1.46747990
44MP0000313_abnormal_cell_death1.45533731
45MP0001873_stomach_inflammation1.44601625
46MP0005075_abnormal_melanosome_morpholog1.44593041
47MP0005174_abnormal_tail_pigmentation1.40268919
48MP0006072_abnormal_retinal_apoptosis1.40211906
49MP0010352_gastrointestinal_tract_polyps1.38880310
50MP0002429_abnormal_blood_cell1.38407412
51MP0001661_extended_life_span1.38383906
52MP0005671_abnormal_response_to1.36544631
53MP0001764_abnormal_homeostasis1.35552708
54MP0000716_abnormal_immune_system1.32202244
55MP0010307_abnormal_tumor_latency1.31435931
56MP0008872_abnormal_physiological_respon1.30622093
57MP0002080_prenatal_lethality1.25998729
58MP0004233_abnormal_muscle_weight1.25107686
59MP0002420_abnormal_adaptive_immunity1.22617178
60MP0005551_abnormal_eye_electrophysiolog1.22172485
61MP0002452_abnormal_antigen_presenting1.21541137
62MP0001819_abnormal_immune_cell1.21099106
63MP0008789_abnormal_olfactory_epithelium1.20909184
64MP0005380_embryogenesis_phenotype1.20883338
65MP0001672_abnormal_embryogenesis/_devel1.20883338
66MP0002938_white_spotting1.20598770
67MP0000685_abnormal_immune_system1.19000246
68MP0005379_endocrine/exocrine_gland_phen1.18950819
69MP0002723_abnormal_immune_serum1.16742401
70MP0002736_abnormal_nociception_after1.14362825
71MP0003984_embryonic_growth_retardation1.12653369
72MP0003646_muscle_fatigue1.11126322
73MP0003221_abnormal_cardiomyocyte_apopto1.10775547
74MP0001929_abnormal_gametogenesis1.09641409
75MP0002088_abnormal_embryonic_growth/wei1.08222324
76MP0001968_abnormal_touch/_nociception1.07500106
77MP0005025_abnormal_response_to1.06582745
78MP0001697_abnormal_embryo_size1.05514693
79MP0003195_calcinosis1.05488832
80MP0002132_abnormal_respiratory_system1.02748744
81MP0006035_abnormal_mitochondrial_morpho1.02367265
82MP0003656_abnormal_erythrocyte_physiolo1.02332765
83MP0001346_abnormal_lacrimal_gland1.01315641
84MP0004133_heterotaxia1.01225299
85MP0010155_abnormal_intestine_physiology1.00645432
86MP0009785_altered_susceptibility_to1.00119178
87MP0002086_abnormal_extraembryonic_tissu0.97447599
88MP0005253_abnormal_eye_physiology0.97354693
89MP0005464_abnormal_platelet_physiology0.97261772
90MP0000858_altered_metastatic_potential0.95762686
91MP0003123_paternal_imprinting0.95621395
92MP0005646_abnormal_pituitary_gland0.93939263
93MP0002234_abnormal_pharynx_morphology0.93577364
94MP0000358_abnormal_cell_content/0.90422639
95MP0003567_abnormal_fetal_cardiomyocyte0.89416301
96MP0002405_respiratory_system_inflammati0.89180033
97MP0002210_abnormal_sex_determination0.88310231
98MP0004197_abnormal_fetal_growth/weight/0.88107977
99MP0002160_abnormal_reproductive_system0.87880978
100MP0005266_abnormal_metabolism0.87803655
101MP0005332_abnormal_amino_acid0.87679485
102MP0000598_abnormal_liver_morphology0.86070798
103MP0001293_anophthalmia0.85765502
104MP0000631_abnormal_neuroendocrine_gland0.84973895
105MP0009697_abnormal_copulation0.84919400
106MP0000371_diluted_coat_color0.84159860
107MP0003698_abnormal_male_reproductive0.83724121
108MP0003718_maternal_effect0.82287633
109MP0003315_abnormal_perineum_morphology0.82045564
110MP0002419_abnormal_innate_immunity0.81805621
111MP0005319_abnormal_enzyme/_coenzyme0.81791270
112MP0005499_abnormal_olfactory_system0.81592112
113MP0005394_taste/olfaction_phenotype0.81592112
114MP0005000_abnormal_immune_tolerance0.81375635
115MP0004142_abnormal_muscle_tone0.80205118
116MP0006276_abnormal_autonomic_nervous0.79705105
117MP0003787_abnormal_imprinting0.78899695
118MP0001905_abnormal_dopamine_level0.78630576
119MP0002928_abnormal_bile_duct0.78417388
120MP0008775_abnormal_heart_ventricle0.78381465
121MP0001845_abnormal_inflammatory_respons0.78152342
122MP0005365_abnormal_bile_salt0.77126758
123MP0001986_abnormal_taste_sensitivity0.76825059
124MP0002085_abnormal_embryonic_tissue0.76810955
125MP0000653_abnormal_sex_gland0.75536119
126MP0004147_increased_porphyrin_level0.75146649
127MP0008469_abnormal_protein_level0.74383613
128MP0005408_hypopigmentation0.73452598
129MP0005389_reproductive_system_phenotype0.73246177
130MP0003436_decreased_susceptibility_to0.73150716
131MP0002084_abnormal_developmental_patter0.72691662
132MP0000609_abnormal_liver_physiology0.71868119
133MP0005085_abnormal_gallbladder_physiolo0.71714198
134MP0003137_abnormal_impulse_conducting0.71645043
135MP0002095_abnormal_skin_pigmentation0.70967263
136MP0002075_abnormal_coat/hair_pigmentati0.70735538
137MP0001727_abnormal_embryo_implantation0.70042615
138MP0002138_abnormal_hepatobiliary_system0.69947849
139MP0001145_abnormal_male_reproductive0.69457739
140MP0003866_abnormal_defecation0.68946961
141MP0010030_abnormal_orbit_morphology0.68691089
142MP0003941_abnormal_skin_development0.68217597
143MP0002148_abnormal_hypersensitivity_rea0.68078435
144MP0005220_abnormal_exocrine_pancreas0.67933826
145MP0001790_abnormal_immune_system0.67708551
146MP0005387_immune_system_phenotype0.67708551
147MP0002269_muscular_atrophy0.67536651
148MP0005384_cellular_phenotype0.67303058
149MP0005330_cardiomyopathy0.67105996
150MP0009379_abnormal_foot_pigmentation0.66565609
151MP0003121_genomic_imprinting0.65977432
152MP0000678_abnormal_parathyroid_gland0.65521667
153MP0001919_abnormal_reproductive_system0.64962874
154MP0002653_abnormal_ependyma_morphology0.63856227
155MP0002638_abnormal_pupillary_reflex0.62476523
156MP0009046_muscle_twitch0.62296935
157MP0001984_abnormal_olfaction0.60835948
158MP0005084_abnormal_gallbladder_morpholo0.59973853
159MP0000750_abnormal_muscle_regeneration0.59971505
160MP0002277_abnormal_respiratory_mucosa0.59951198

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.82006405
2Abnormality of cells of the erythroid lineage (HP:0012130)4.63753403
3Abnormal number of erythroid precursors (HP:0012131)4.58866131
4Acute necrotizing encephalopathy (HP:0006965)4.33444778
5Acute encephalopathy (HP:0006846)4.30065400
6Abnormal mitochondria in muscle tissue (HP:0008316)4.22923522
7Thrombocytosis (HP:0001894)3.82870080
8Mitochondrial inheritance (HP:0001427)3.81236099
9Birth length less than 3rd percentile (HP:0003561)3.77526176
10Oral leukoplakia (HP:0002745)3.65355417
11Progressive macrocephaly (HP:0004481)3.52863013
12Chromsome breakage (HP:0040012)3.48637002
13Cerebral edema (HP:0002181)3.36387488
14Aplastic anemia (HP:0001915)3.31470129
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.27579335
16Abnormality of DNA repair (HP:0003254)3.10704232
17Abnormality of pyrimidine metabolism (HP:0004353)3.01474399
18Macrocytic anemia (HP:0001972)3.01225846
19Pallor (HP:0000980)2.99190576
20Colon cancer (HP:0003003)2.98470910
21Lipid accumulation in hepatocytes (HP:0006561)2.93460487
22Selective tooth agenesis (HP:0001592)2.92895337
233-Methylglutaconic aciduria (HP:0003535)2.90690260
24Increased hepatocellular lipid droplets (HP:0006565)2.84869052
25Increased intramyocellular lipid droplets (HP:0012240)2.76651099
26Poikiloderma (HP:0001029)2.70623469
27Agnosia (HP:0010524)2.70353513
28Hyperglycinemia (HP:0002154)2.70214227
29Exercise intolerance (HP:0003546)2.65797230
30Medulloblastoma (HP:0002885)2.64216399
31Pancreatic cysts (HP:0001737)2.63228771
32Hepatic necrosis (HP:0002605)2.61769965
33Abnormality of the preputium (HP:0100587)2.61567155
34Myelodysplasia (HP:0002863)2.59911298
35Pendular nystagmus (HP:0012043)2.57873769
36Absent thumb (HP:0009777)2.57139867
37Hyperglycinuria (HP:0003108)2.57134697
38Rough bone trabeculation (HP:0100670)2.55607804
39Ependymoma (HP:0002888)2.53501901
4011 pairs of ribs (HP:0000878)2.53314219
41Lethargy (HP:0001254)2.51984540
42Pancytopenia (HP:0001876)2.51009688
43Methylmalonic aciduria (HP:0012120)2.50772189
44Amaurosis fugax (HP:0100576)2.50075724
45Abnormality of chromosome stability (HP:0003220)2.50013199
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49267269
47Abnormality of alanine metabolism (HP:0010916)2.49267269
48Hyperalaninemia (HP:0003348)2.49267269
49Optic disc pallor (HP:0000543)2.48853560
50Hepatocellular necrosis (HP:0001404)2.48849950
51Increased muscle lipid content (HP:0009058)2.48071033
52Type I transferrin isoform profile (HP:0003642)2.45529764
53Abnormality of reticulocytes (HP:0004312)2.43450635
54Lymphoma (HP:0002665)2.42582320
55Carpal bone hypoplasia (HP:0001498)2.41332102
56Bone marrow hypocellularity (HP:0005528)2.41248974
57Breast hypoplasia (HP:0003187)2.40498879
58IgM deficiency (HP:0002850)2.36923334
59Meckel diverticulum (HP:0002245)2.33717413
60* Increased serum lactate (HP:0002151)2.33152376
61Microvesicular hepatic steatosis (HP:0001414)2.33103990
62Cellular immunodeficiency (HP:0005374)2.30762379
63Respiratory failure (HP:0002878)2.30425647
64Pancreatic fibrosis (HP:0100732)2.30049788
65Methylmalonic acidemia (HP:0002912)2.29420647
66Abnormality of the heme biosynthetic pathway (HP:0010472)2.29060617
67Progressive microcephaly (HP:0000253)2.27303666
68Elevated erythrocyte sedimentation rate (HP:0003565)2.26977858
69Abnormality of glycolysis (HP:0004366)2.26775301
70Duplicated collecting system (HP:0000081)2.26720798
71Abnormality of serine family amino acid metabolism (HP:0010894)2.26691135
72Abnormality of glycine metabolism (HP:0010895)2.26691135
73Abnormality of the ileum (HP:0001549)2.26632940
74Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21941946
75Degeneration of anterior horn cells (HP:0002398)2.21912516
76Abnormality of the anterior horn cell (HP:0006802)2.21912516
77Entropion (HP:0000621)2.20189703
78Reduced antithrombin III activity (HP:0001976)2.17201708
79Basal cell carcinoma (HP:0002671)2.16668698
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14551483
81Testicular atrophy (HP:0000029)2.14478738
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13582226
83Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13582226
84Abnormality of the renal collecting system (HP:0004742)2.13478736
85Aplasia/Hypoplasia of the uvula (HP:0010293)2.11496451
86Asplenia (HP:0001746)2.11285786
87Abnormality of midbrain morphology (HP:0002418)2.11083187
88Molar tooth sign on MRI (HP:0002419)2.11083187
89Increased serum pyruvate (HP:0003542)2.10096922
90Horseshoe kidney (HP:0000085)2.08432070
91Premature graying of hair (HP:0002216)2.06787161
92Abnormality of T cells (HP:0002843)2.05799722
93Abnormality of the labia minora (HP:0012880)2.01301039
94Retinal dysplasia (HP:0007973)2.00707212
95Abnormality of sulfur amino acid metabolism (HP:0004339)2.00275940
96Patellar aplasia (HP:0006443)1.99271967
97Ketosis (HP:0001946)1.98919250
98Homocystinuria (HP:0002156)1.98438625
99Abnormality of homocysteine metabolism (HP:0010919)1.98438625
100Renal Fanconi syndrome (HP:0001994)1.96738290
101Abnormality of methionine metabolism (HP:0010901)1.96214547
102Nausea (HP:0002018)1.94856395
103Abnormality of T cell physiology (HP:0011840)1.93383172
104Myoglobinuria (HP:0002913)1.93267897
105Renal cortical cysts (HP:0000803)1.92972093
106Sloping forehead (HP:0000340)1.92561825
107True hermaphroditism (HP:0010459)1.92423974
108Progressive muscle weakness (HP:0003323)1.92379221
109Megaloblastic anemia (HP:0001889)1.91941889
110Multiple enchondromatosis (HP:0005701)1.91923434
111Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90735835
112Prolonged bleeding time (HP:0003010)1.88470158
113Rhabdomyolysis (HP:0003201)1.88421353
114Aplasia/Hypoplasia of the spleen (HP:0010451)1.88334554
115T lymphocytopenia (HP:0005403)1.88161848
116Rhabdomyosarcoma (HP:0002859)1.87912250
117Microretrognathia (HP:0000308)1.87679720
118Attenuation of retinal blood vessels (HP:0007843)1.86856071
119Sclerocornea (HP:0000647)1.85765772
120Neoplasm of the adrenal gland (HP:0100631)1.84920679
121Type II lissencephaly (HP:0007260)1.83290880
122Abnormal trabecular bone morphology (HP:0100671)1.83278093
123Duodenal stenosis (HP:0100867)1.82773505
124Small intestinal stenosis (HP:0012848)1.82773505
125Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82521192
126Dicarboxylic aciduria (HP:0003215)1.82521192
127Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82233589
128Abnormal protein N-linked glycosylation (HP:0012347)1.82233589
129Abnormal protein glycosylation (HP:0012346)1.82233589
130Abnormal glycosylation (HP:0012345)1.82233589
131Leukodystrophy (HP:0002415)1.81593794
132Neoplasm of the pancreas (HP:0002894)1.81490082
133Muscle fiber atrophy (HP:0100295)1.81409977
134Lactic acidosis (HP:0003128)1.81090757
135Increased CSF lactate (HP:0002490)1.80990715
136Abnormality of serum amino acid levels (HP:0003112)1.80394944
137Aplasia/Hypoplasia of the patella (HP:0006498)1.80181448
138Type 2 muscle fiber atrophy (HP:0003554)1.79572096
139Abnormal rod and cone electroretinograms (HP:0008323)1.79563416
140CNS demyelination (HP:0007305)1.79353526
141Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78687692
142Ectopic kidney (HP:0000086)1.77793603
143Hyperammonemia (HP:0001987)1.77614253
144Abnormality of T cell number (HP:0011839)1.77487916
145Leukopenia (HP:0001882)1.77432923
146Impulsivity (HP:0100710)1.76739306
147Prominent metopic ridge (HP:0005487)1.75810254
148Cerebral hypomyelination (HP:0006808)1.73220658
149Squamous cell carcinoma (HP:0002860)1.72314836
150Petechiae (HP:0000967)1.71641144
151Premature ovarian failure (HP:0008209)1.70584143
152Granulocytopenia (HP:0001913)1.70445718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.15680862
2BUB13.39656372
3WEE13.31265918
4CDC73.14347264
5EIF2AK12.93167656
6NME22.54895894
7NUAK12.53981294
8MAP4K12.44720618
9NME12.39925673
10SRPK12.33905324
11MAP2K32.28352235
12TSSK62.23938606
13NEK22.21607834
14EEF2K2.21323703
15STK162.13363228
16BCKDK2.11470553
17FRK2.03738152
18TLK11.94646279
19RPS6KB21.93533113
20NEK11.93518366
21CDK121.85230300
22PHKG11.80769628
23PHKG21.80769628
24FLT31.74545398
25ATR1.72299185
26TTK1.71118223
27KIT1.69007180
28IRAK31.66029782
29PASK1.58887165
30TXK1.53408096
31PLK11.52479131
32PBK1.52139811
33EIF2AK31.51774472
34VRK11.48745683
35PDK21.48136233
36TAOK31.46917878
37AURKB1.38674501
38CDK71.37378591
39MAP3K31.37295590
40ZAK1.35623867
41TRIM281.34351903
42TAF11.32346946
43CDK41.25759999
44EPHA21.24798372
45MAP4K21.24668659
46ADRBK21.22906275
47OBSCN1.21721539
48SCYL21.21705263
49TGFBR11.21697174
50JAK31.20680667
51STK101.18956331
52BRD41.18466222
53PIM21.18346547
54PKN21.16133596
55PLK41.13112899
56PIM11.12037112
57MAPKAPK31.11468434
58STK41.10983343
59TEC1.10978719
60ACVR1B1.08693131
61MAP3K81.07343937
62BRSK21.06393916
63WNK41.05066369
64DYRK31.04870360
65RPS6KA41.03018265
66TESK20.99678267
67BTK0.99012194
68MAPKAPK50.98521100
69KDR0.96534081
70FGFR40.95404720
71ZAP700.95324087
72TYK20.94736812
73AURKA0.93853324
74CHEK10.92383840
75BLK0.92158553
76MKNK10.91398704
77CDK190.90119191
78CSNK1G30.89460734
79MAP3K100.89418011
80DAPK10.87577475
81LRRK20.86570476
82SMG10.85907043
83CHEK20.81128239
84IRAK40.80446370
85PAK40.80332411
86PLK30.77781507
87EIF2AK20.77742909
88DYRK20.73976900
89CCNB10.73537165
90GRK10.70278095
91MAP3K140.69999864
92TIE10.68963390
93ATM0.68617141
94BMPR1B0.67166577
95CSNK2A20.65981527
96CSNK1G10.65067140
97IKBKB0.64508849
98CDK20.63270616
99PINK10.59538057
100TTN0.59109915
101PRKD30.58728126
102SIK20.58246400
103MAPK110.57732376
104MAPK130.56017144
105CSNK2A10.55645953
106SYK0.55005318
107WNK30.53065104
108IKBKE0.52701843
109MAP2K60.50918410
110CSNK1A1L0.50526975
111TAOK20.50414441
112CDK30.49705334
113PDK30.49148825
114PDK40.49148825
115LYN0.47682353
116BRSK10.44455198
117MUSK0.43956920
118ALK0.43272170
119PRPF4B0.42434435
120RPS6KA50.42153782
121CDK80.41982155
122ITK0.41731107
123AKT20.41570966
124PRKAA10.41538034
125PRKDC0.41396017
126CDK10.40528303
127TBK10.40421647
128GRK60.40384462
129OXSR10.40340256
130CSNK1G20.40163474
131LCK0.40010131
132MST40.39975125
133CSNK1A10.39464013
134CSNK1E0.39302702
135PIK3CG0.39266316
136CDK60.39054673
137CSF1R0.38463083
138RPS6KC10.37785318
139RPS6KL10.37785318
140PRKCI0.37631586
141MKNK20.36340423
142LIMK10.29865367
143CAMK2D0.29235282
144RAF10.27593714
145PAK10.26921075

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.55276464
2Mismatch repair_Homo sapiens_hsa034303.77443467
3Ribosome_Homo sapiens_hsa030103.66361682
4One carbon pool by folate_Homo sapiens_hsa006703.29118996
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07813451
6Proteasome_Homo sapiens_hsa030502.84310943
7* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.84045002
8Base excision repair_Homo sapiens_hsa034102.78450176
9RNA polymerase_Homo sapiens_hsa030202.78403712
10Spliceosome_Homo sapiens_hsa030402.63040284
11Homologous recombination_Homo sapiens_hsa034402.62089816
12Nucleotide excision repair_Homo sapiens_hsa034202.49734423
13RNA transport_Homo sapiens_hsa030132.36889995
14Pyrimidine metabolism_Homo sapiens_hsa002402.34729796
15Non-homologous end-joining_Homo sapiens_hsa034502.14469799
16Fanconi anemia pathway_Homo sapiens_hsa034601.92635849
17Cell cycle_Homo sapiens_hsa041101.81290272
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72554033
19Fatty acid elongation_Homo sapiens_hsa000621.60241964
20RNA degradation_Homo sapiens_hsa030181.55927169
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52626730
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51929074
23Selenocompound metabolism_Homo sapiens_hsa004501.51217482
24Biosynthesis of amino acids_Homo sapiens_hsa012301.47500973
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.43218940
26Alzheimers disease_Homo sapiens_hsa050101.31828097
27Butanoate metabolism_Homo sapiens_hsa006501.31722217
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31022900
29Carbon metabolism_Homo sapiens_hsa012001.28067811
30Sulfur relay system_Homo sapiens_hsa041221.27150612
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.25884306
32p53 signaling pathway_Homo sapiens_hsa041151.22964230
33Purine metabolism_Homo sapiens_hsa002301.20414528
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19938609
35Primary immunodeficiency_Homo sapiens_hsa053401.17572232
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.16939791
37Pentose phosphate pathway_Homo sapiens_hsa000301.15589258
38Basal transcription factors_Homo sapiens_hsa030221.13618437
39Folate biosynthesis_Homo sapiens_hsa007901.10964941
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09467337
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09289524
42Systemic lupus erythematosus_Homo sapiens_hsa053221.07761394
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05259767
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03534197
45mRNA surveillance pathway_Homo sapiens_hsa030151.03002433
46Epstein-Barr virus infection_Homo sapiens_hsa051691.01059400
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98534418
48Antigen processing and presentation_Homo sapiens_hsa046120.97629595
49Herpes simplex infection_Homo sapiens_hsa051680.94620214
50Steroid biosynthesis_Homo sapiens_hsa001000.91873914
51Cardiac muscle contraction_Homo sapiens_hsa042600.85419211
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83848896
53Propanoate metabolism_Homo sapiens_hsa006400.83710517
54Sulfur metabolism_Homo sapiens_hsa009200.81843463
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81281824
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81024124
57Fructose and mannose metabolism_Homo sapiens_hsa000510.76502240
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74970272
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70300277
60Fatty acid degradation_Homo sapiens_hsa000710.70276706
61Pyruvate metabolism_Homo sapiens_hsa006200.70199105
62Legionellosis_Homo sapiens_hsa051340.67605470
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66551015
64Measles_Homo sapiens_hsa051620.65993620
65Viral carcinogenesis_Homo sapiens_hsa052030.65588925
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62890224
67Nitrogen metabolism_Homo sapiens_hsa009100.59259032
68Lysine degradation_Homo sapiens_hsa003100.59000165
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.57935002
70Glutathione metabolism_Homo sapiens_hsa004800.56214961
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56037123
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55256212
73Parkinsons disease_Homo sapiens_hsa050120.54061541
74Vitamin B6 metabolism_Homo sapiens_hsa007500.53544995
75Phototransduction_Homo sapiens_hsa047440.51839274
76Protein export_Homo sapiens_hsa030600.51109892
77Galactose metabolism_Homo sapiens_hsa000520.50286716
78Hematopoietic cell lineage_Homo sapiens_hsa046400.49042512
79Huntingtons disease_Homo sapiens_hsa050160.49028058
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47753065
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.46563168
82Asthma_Homo sapiens_hsa053100.45450552
83HTLV-I infection_Homo sapiens_hsa051660.44612626
84Metabolic pathways_Homo sapiens_hsa011000.43240483
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43155971
86Apoptosis_Homo sapiens_hsa042100.42534872
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41445117
88Linoleic acid metabolism_Homo sapiens_hsa005910.39966262
89beta-Alanine metabolism_Homo sapiens_hsa004100.39109818
90Caffeine metabolism_Homo sapiens_hsa002320.36593410
91Influenza A_Homo sapiens_hsa051640.35549075
92Peroxisome_Homo sapiens_hsa041460.33596483
93N-Glycan biosynthesis_Homo sapiens_hsa005100.32930531
94Arginine and proline metabolism_Homo sapiens_hsa003300.32572719
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32006167
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31872192
97Autoimmune thyroid disease_Homo sapiens_hsa053200.31770134
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.30844322
99Tryptophan metabolism_Homo sapiens_hsa003800.29104830
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29028014
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28319292
102Oxidative phosphorylation_Homo sapiens_hsa001900.27611301
103Chemical carcinogenesis_Homo sapiens_hsa052040.26558353
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26557140
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.25633846
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25347565
107Tyrosine metabolism_Homo sapiens_hsa003500.24540807
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24233219
109Acute myeloid leukemia_Homo sapiens_hsa052210.24157364
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24018023
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23201314
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22928068
113Allograft rejection_Homo sapiens_hsa053300.22810062
114Graft-versus-host disease_Homo sapiens_hsa053320.22094173
115Type I diabetes mellitus_Homo sapiens_hsa049400.22091719
116Fatty acid metabolism_Homo sapiens_hsa012120.21506287
117Thyroid cancer_Homo sapiens_hsa052160.20587865
118Small cell lung cancer_Homo sapiens_hsa052220.19678754
119B cell receptor signaling pathway_Homo sapiens_hsa046620.19393056
120HIF-1 signaling pathway_Homo sapiens_hsa040660.19117792
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18796320
122Arginine biosynthesis_Homo sapiens_hsa002200.18737249
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.16681791
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.16141261
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15641071
126Hepatitis B_Homo sapiens_hsa051610.15187540

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