ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	6.17888960
2	adult feeding behavior (GO:0008343)	5.99176093
3	response to parathyroid hormone (GO:0071107)	5.87162949
4	cilium or flagellum-dependent cell motility (GO:0001539)	4.67411718
5	positive regulation of respiratory burst (GO:0060267)	4.57783709
6	regulation of feeding behavior (GO:0060259)	4.57321273
7	secondary metabolite biosynthetic process (GO:0044550)	4.00978968
8	response to dietary excess (GO:0002021)	3.80791656
9	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.68985587
10	axonal fasciculation (GO:0007413)	3.65872230
11	labyrinthine layer development (GO:0060711)	3.56323320
12	ventricular system development (GO:0021591)	3.54406568
13	melanin biosynthetic process (GO:0042438)	3.42747871
14	endothelium development (GO:0003158)	3.34800536
15	L-phenylalanine catabolic process (GO:0006559)	3.26298256
16	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.26298256
17	positive regulation of vesicle fusion (GO:0031340)	3.23032313
18	cilium movement (GO:0003341)	3.21598010
19	cell proliferation in forebrain (GO:0021846)	3.14102046
20	response to lipoprotein particle (GO:0055094)	3.10017783
21	neuron recognition (GO:0008038)	3.08761068
22	negative regulation of metanephros development (GO:0072217)	2.99252784
23	melanin metabolic process (GO:0006582)	2.97881582
24	dendritic spine morphogenesis (GO:0060997)	2.95452657
25	gap junction assembly (GO:0016264)	2.92137694
26	viral transcription (GO:0019083)	2.88337804
27	atrial cardiac muscle cell action potential (GO:0086014)	2.87168235
28	L-alpha-amino acid transmembrane transport (GO:1902475)	2.87158717
29	regulation of vesicle fusion (GO:0031338)	2.86587995
30	locomotory exploration behavior (GO:0035641)	2.85553363
31	axon ensheathment in central nervous system (GO:0032291)	2.84690286
32	central nervous system myelination (GO:0022010)	2.84690286
33	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.83830456
34	* detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.82522261
35	GTP biosynthetic process (GO:0006183)	2.80308031
36	nucleoside diphosphate phosphorylation (GO:0006165)	2.80295719
37	detection of calcium ion (GO:0005513)	2.80099167
38	axoneme assembly (GO:0035082)	2.75782849
39	negative regulation of protein localization to cell surface (GO:2000009)	2.74895819
40	fatty acid elongation (GO:0030497)	2.74687046
41	cerebral cortex radially oriented cell migration (GO:0021799)	2.74125049
42	neuron remodeling (GO:0016322)	2.73763964
43	response to methylmercury (GO:0051597)	2.73040603
44	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.72009835
45	aromatic amino acid family catabolic process (GO:0009074)	2.68754331
46	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.66855719
47	L-phenylalanine metabolic process (GO:0006558)	2.66855719
48	phospholipid efflux (GO:0033700)	2.66769472
49	ribosomal small subunit biogenesis (GO:0042274)	2.64234825
50	epithelial cell differentiation involved in kidney development (GO:0035850)	2.63672572
51	neuronal action potential propagation (GO:0019227)	2.63532245
52	drinking behavior (GO:0042756)	2.61838079
53	translational termination (GO:0006415)	2.61301033
54	dendrite morphogenesis (GO:0048813)	2.60615101
55	neuron cell-cell adhesion (GO:0007158)	2.60556335
56	neuromuscular process controlling posture (GO:0050884)	2.58898257
57	response to pH (GO:0009268)	2.58625558
58	substrate-independent telencephalic tangential migration (GO:0021826)	2.58492169
59	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.58492169
60	cholesterol efflux (GO:0033344)	2.58167060
61	striated muscle cell proliferation (GO:0014855)	2.56004578
62	sexual reproduction (GO:0019953)	2.52565547
63	cellular response to cholesterol (GO:0071397)	2.51550917
64	short-chain fatty acid metabolic process (GO:0046459)	2.51271354
65	muscle cell proliferation (GO:0033002)	2.47075558
66	phospholipid homeostasis (GO:0055091)	2.46139378
67	opioid receptor signaling pathway (GO:0038003)	2.45144617
68	dicarboxylic acid catabolic process (GO:0043649)	2.44772192
69	coenzyme catabolic process (GO:0009109)	2.43448399
70	* detection of chemical stimulus involved in sensory perception (GO:0050907)	2.43432745
71	UTP biosynthetic process (GO:0006228)	2.42993045
72	post-embryonic morphogenesis (GO:0009886)	2.42791479
73	forebrain neuron differentiation (GO:0021879)	2.42615204
74	NAD biosynthetic process (GO:0009435)	2.42260441
75	innervation (GO:0060384)	2.42039614
76	tooth mineralization (GO:0034505)	2.41743205
77	glial cell migration (GO:0008347)	2.41220013
78	mesenchymal to epithelial transition (GO:0060231)	2.40998896
79	potassium ion import (GO:0010107)	2.40666741
80	RNA destabilization (GO:0050779)	2.40355989
81	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.39453907
82	negative regulation of execution phase of apoptosis (GO:1900118)	2.38704144
83	cellular response to pH (GO:0071467)	2.38338847
84	regulation of T cell tolerance induction (GO:0002664)	2.37782342
85	plasma lipoprotein particle assembly (GO:0034377)	2.37028041
86	reverse cholesterol transport (GO:0043691)	2.33675969
87	positive regulation of glycogen biosynthetic process (GO:0045725)	2.33067106
88	endocrine pancreas development (GO:0031018)	2.32022603
89	kynurenine metabolic process (GO:0070189)	2.31483490
90	cellular response to sterol (GO:0036315)	2.30669471
91	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.30522627
92	response to acidic pH (GO:0010447)	2.30492333
93	platelet dense granule organization (GO:0060155)	2.27772806
94	import into cell (GO:0098657)	2.26810893
95	nicotinamide nucleotide biosynthetic process (GO:0019359)	2.26354561
96	pyridine nucleotide biosynthetic process (GO:0019363)	2.26354561
97	I-kappaB phosphorylation (GO:0007252)	2.26140640
98	cellular copper ion homeostasis (GO:0006878)	2.25760465
99	response to laminar fluid shear stress (GO:0034616)	2.25094534
100	UTP metabolic process (GO:0046051)	2.24878907

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.61929494
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.30156078
3	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.63067861
4	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.56197507
5	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.51687985
6	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.45664499
7	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.43059282
8	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.38443644
9	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.33551282
10	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.31210219
11	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.31133788
12	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.24852649
13	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.24038056
14	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.23662142
15	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.20747837
16	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.20200240
17	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.12931271
18	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.08789386
19	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.08789386
20	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.08418175
21	GBX2_23144817_ChIP-Seq_PC3_Human	2.05858675
22	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.96388673
23	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.96114753
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.88894236
25	DROSHA_22980978_ChIP-Seq_HELA_Human	1.88566041
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.86707450
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.51069770
28	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.47693559
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.46128545
30	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.43846263
31	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.43490288
32	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.42298416
33	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.36534734
34	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.36013737
35	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.34174561
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33957318
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.33645046
38	REST_21632747_ChIP-Seq_MESCs_Mouse	1.33406721
39	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.33117466
40	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.33099443
41	AR_21572438_ChIP-Seq_LNCaP_Human	1.31981023
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.26783013
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25862439
44	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.24101982
45	P300_19829295_ChIP-Seq_ESCs_Human	1.24084849
46	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.23228025
47	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.22439757
48	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21103116
49	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.19294923
50	* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18314826
51	* POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.18314826
52	SMAD4_21799915_ChIP-Seq_A2780_Human	1.16694726
53	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14667589
54	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13932879
55	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.12245907
56	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.11069811
57	ZNF274_21170338_ChIP-Seq_K562_Hela	1.09337301
58	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07988705
59	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.06346179
60	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.06290812
61	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.02111107
62	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.01925176
63	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.00653770
64	TP53_18474530_ChIP-ChIP_U2OS_Human	0.99902786
65	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.99229448
66	VDR_22108803_ChIP-Seq_LS180_Human	0.98041291
67	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97929153
68	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.97483447
69	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.97440294
70	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.97330974
71	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.96569633
72	* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.95033942
73	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.94946930
74	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.94594823
75	* KDM2B_26808549_Chip-Seq_REH_Human	0.94282551
76	KDM2B_26808549_Chip-Seq_K562_Human	0.94103494
77	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.92105642
78	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.92008842
79	GF1_26923725_Chip-Seq_HPCs_Mouse	0.91853116
80	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.91068375
81	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.90832342
82	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.90269125
83	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.89817488
84	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.89490885
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88548315
86	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.86595440
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.85809316
88	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.84956667
89	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.84449958
90	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.84162097
91	* RUNX2_22187159_ChIP-Seq_PCA_Human	0.83959496
92	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.82911114
93	TP53_16413492_ChIP-PET_HCT116_Human	0.82466942
94	ER_23166858_ChIP-Seq_MCF-7_Human	0.82130091
95	STAT3_23295773_ChIP-Seq_U87_Human	0.81979939
96	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.80981898
97	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.80805101
98	* CTCF_27219007_Chip-Seq_Bcells_Human	0.80641702
99	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.80481711
100	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.80059761

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003123_paternal_imprinting	4.16072822
2	MP0003122_maternal_imprinting	3.98471251
3	MP0005379_endocrine/exocrine_gland_phen	3.70487219
4	MP0000013_abnormal_adipose_tissue	3.53477063
5	MP0004270_analgesia	3.44749886
6	MP0009379_abnormal_foot_pigmentation	3.27536720
7	MP0005623_abnormal_meninges_morphology	3.11902796
8	MP0005645_abnormal_hypothalamus_physiol	3.09861948
9	MP0002163_abnormal_gland_morphology	3.03196191
10	MP0003121_genomic_imprinting	2.83743268
11	MP0003195_calcinosis	2.65493527
12	MP0002254_reproductive_system_inflammat	2.23585584
13	MP0001661_extended_life_span	2.03852695
14	MP0010368_abnormal_lymphatic_system	1.89463569
15	MP0003252_abnormal_bile_duct	1.82905926
16	MP0004859_abnormal_synaptic_plasticity	1.81790256
17	MP0005084_abnormal_gallbladder_morpholo	1.72300462
18	MP0003635_abnormal_synaptic_transmissio	1.70394635
19	MP0000462_abnormal_digestive_system	1.70138596
20	MP0005360_urolithiasis	1.69182341
21	MP0008438_abnormal_cutaneous_collagen	1.69150965
22	MP0000003_abnormal_adipose_tissue	1.68821804
23	MP0004019_abnormal_vitamin_homeostasis	1.66523480
24	MP0003950_abnormal_plasma_membrane	1.63950591
25	MP0002837_dystrophic_cardiac_calcinosis	1.62694015
26	MP0000631_abnormal_neuroendocrine_gland	1.59607561
27	MP0002272_abnormal_nervous_system	1.55482081
28	* MP0005423_abnormal_somatic_nervous	1.49301832
29	MP0002734_abnormal_mechanical_nocicepti	1.47202716
30	MP0002736_abnormal_nociception_after	1.46512184
31	MP0002139_abnormal_hepatobiliary_system	1.45856664
32	MP0002064_seizures	1.43238115
33	MP0001968_abnormal_touch/_nociception	1.41688904
34	MP0005167_abnormal_blood-brain_barrier	1.41084374
35	MP0003279_aneurysm	1.39564009
36	MP0009745_abnormal_behavioral_response	1.31708844
37	MP0003191_abnormal_cellular_cholesterol	1.31336713
38	MP0003959_abnormal_lean_body	1.31165099
39	MP0000778_abnormal_nervous_system	1.30671701
40	MP0002063_abnormal_learning/memory/cond	1.27759429
41	MP0001970_abnormal_pain_threshold	1.26464516
42	MP0002733_abnormal_thermal_nociception	1.25634019
43	MP0001440_abnormal_grooming_behavior	1.24338574
44	MP0001501_abnormal_sleep_pattern	1.23953271
45	MP0003880_abnormal_central_pattern	1.21499648
46	MP0001188_hyperpigmentation	1.19631493
47	MP0003137_abnormal_impulse_conducting	1.16569015
48	MP0002557_abnormal_social/conspecific_i	1.16419272
49	MP0002751_abnormal_autonomic_nervous	1.14440677
50	MP0002249_abnormal_larynx_morphology	1.14022716
51	MP0001485_abnormal_pinna_reflex	1.13855022
52	MP0000049_abnormal_middle_ear	1.13385892
53	MP0003045_fibrosis	1.10848215
54	MP0002572_abnormal_emotion/affect_behav	1.09397404
55	MP0005085_abnormal_gallbladder_physiolo	1.07974080
56	MP0010234_abnormal_vibrissa_follicle	1.07200306
57	MP0005409_darkened_coat_color	1.07036841
58	MP0000920_abnormal_myelination	1.06181601
59	MP0001486_abnormal_startle_reflex	1.04165872
60	MP0005503_abnormal_tendon_morphology	1.03168669
61	MP0000639_abnormal_adrenal_gland	1.00222155
62	MP0010030_abnormal_orbit_morphology	0.99109521
63	MP0002184_abnormal_innervation	0.98033629
64	MP0010329_abnormal_lipoprotein_level	0.96752627
65	MP0004742_abnormal_vestibular_system	0.96254071
66	MP0005448_abnormal_energy_balance	0.95702592
67	MP0005365_abnormal_bile_salt	0.95492625
68	MP0000604_amyloidosis	0.93658660
69	MP0006276_abnormal_autonomic_nervous	0.92939625
70	MP0002168_other_aberrant_phenotype	0.90711802
71	MP0003183_abnormal_peptide_metabolism	0.88782466
72	MP0000751_myopathy	0.88373498
73	MP0004858_abnormal_nervous_system	0.86134947
74	MP0004133_heterotaxia	0.84167003
75	MP0002882_abnormal_neuron_morphology	0.82061102
76	MP0002295_abnormal_pulmonary_circulatio	0.80526871
77	MP0005174_abnormal_tail_pigmentation	0.79865903
78	MP0002069_abnormal_eating/drinking_beha	0.79663438
79	MP0004883_abnormal_blood_vessel	0.79143755
80	MP0000955_abnormal_spinal_cord	0.78118946
81	MP0006072_abnormal_retinal_apoptosis	0.77834331
82	MP0003385_abnormal_body_wall	0.77559706
83	MP0003690_abnormal_glial_cell	0.76926853
84	MP0002933_joint_inflammation	0.76192933
85	MP0003329_amyloid_beta_deposits	0.76190410
86	MP0003011_delayed_dark_adaptation	0.76165652
87	MP0003634_abnormal_glial_cell	0.75246002
88	MP0001944_abnormal_pancreas_morphology	0.74660583
89	MP0004272_abnormal_basement_membrane	0.73870071
90	MP0003938_abnormal_ear_development	0.72591361
91	MP0001879_abnormal_lymphatic_vessel	0.71465779
92	MP0002108_abnormal_muscle_morphology	0.71378695
93	MP0002066_abnormal_motor_capabilities/c	0.68928748
94	MP0003633_abnormal_nervous_system	0.68366173
95	MP0010678_abnormal_skin_adnexa	0.68252707
96	MP0000427_abnormal_hair_cycle	0.68199267
97	MP0002152_abnormal_brain_morphology	0.68173652
98	MP0010386_abnormal_urinary_bladder	0.68109683
99	MP0002067_abnormal_sensory_capabilities	0.67375487
100	MP0005164_abnormal_response_to	0.66824684

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal ciliary motility (HP:0012262)	4.88723590
2	Ketoacidosis (HP:0001993)	4.85370074
3	Hyperinsulinemic hypoglycemia (HP:0000825)	4.38443485
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.03502877
5	Absent/shortened dynein arms (HP:0200106)	4.03502877
6	Hypoglycemic seizures (HP:0002173)	3.90456507
7	Abnormal respiratory motile cilium physiology (HP:0012261)	3.78626386
8	Neurofibrillary tangles (HP:0002185)	3.76915290
9	Polyphagia (HP:0002591)	3.63719418
10	Abnormal respiratory epithelium morphology (HP:0012253)	3.55046783
11	Abnormal respiratory motile cilium morphology (HP:0005938)	3.55046783
12	Hypoglycemic coma (HP:0001325)	3.48562599
13	Upper limb muscle weakness (HP:0003484)	3.26379148
14	Symptomatic seizures (HP:0011145)	3.24322163
15	Focal motor seizures (HP:0011153)	3.17807968
16	Abnormality of endocrine pancreas physiology (HP:0012093)	3.14067906
17	Abnormality of the pancreatic islet cells (HP:0006476)	3.14067906
18	Pancreatic islet-cell hyperplasia (HP:0004510)	3.13964884
19	Large for gestational age (HP:0001520)	3.13648721
20	Myocardial infarction (HP:0001658)	3.02999384
21	Cerebral inclusion bodies (HP:0100314)	3.01228887
22	Ketosis (HP:0001946)	2.87544355
23	Abnormality of the labia minora (HP:0012880)	2.86974950
24	Submucous cleft hard palate (HP:0000176)	2.79981317
25	Deep venous thrombosis (HP:0002625)	2.78914651
26	Fragile skin (HP:0001030)	2.77448371
27	Congenital malformation of the right heart (HP:0011723)	2.73236592
28	Double outlet right ventricle (HP:0001719)	2.73236592
29	Distal lower limb amyotrophy (HP:0008944)	2.66536264
30	Premature rupture of membranes (HP:0001788)	2.66235281
31	Hypoventilation (HP:0002791)	2.63017364
32	Generalized tonic-clonic seizures (HP:0002069)	2.62333071
33	Abnormal eating behavior (HP:0100738)	2.61073656
34	Late onset (HP:0003584)	2.60546778
35	Hemiparesis (HP:0001269)	2.54986032
36	Hyperglycemia (HP:0003074)	2.49075289
37	Sensorimotor neuropathy (HP:0007141)	2.46824907
38	Supernumerary spleens (HP:0009799)	2.42617842
39	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.41188727
40	Turricephaly (HP:0000262)	2.36729082
41	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.36518563
42	Failure to thrive in infancy (HP:0001531)	2.35972790
43	Metabolic alkalosis (HP:0200114)	2.33314222
44	Supranuclear gaze palsy (HP:0000605)	2.21270920
45	Hypoalphalipoproteinemia (HP:0003233)	2.17379793
46	Oligomenorrhea (HP:0000876)	2.12892640
47	Persistence of primary teeth (HP:0006335)	2.11921279
48	Impaired pain sensation (HP:0007328)	2.11415471
49	Abnormality of pain sensation (HP:0010832)	2.11415471
50	Congenital, generalized hypertrichosis (HP:0004540)	2.09415376
51	Cortical visual impairment (HP:0100704)	2.09271665
52	Anomalous pulmonary venous return (HP:0010772)	2.08627090
53	Hip dysplasia (HP:0001385)	2.05768081
54	Spinal cord compression (HP:0002176)	2.05600041
55	Abnormality of lateral ventricle (HP:0030047)	2.05198542
56	Sleep apnea (HP:0010535)	2.01769056
57	Psychosis (HP:0000709)	2.01317785
58	Protruding tongue (HP:0010808)	2.00523032
59	Lower limb amyotrophy (HP:0007210)	1.98158640
60	Focal seizures (HP:0007359)	1.91906918
61	Recurrent corneal erosions (HP:0000495)	1.90850943
62	Distal lower limb muscle weakness (HP:0009053)	1.90033109
63	Agitation (HP:0000713)	1.87375982
64	Neuronal loss in central nervous system (HP:0002529)	1.86302801
65	Diaphragmatic weakness (HP:0009113)	1.85180170
66	Infantile muscular hypotonia (HP:0008947)	1.84602861
67	Nuclear cataract (HP:0100018)	1.82770540
68	Atonic seizures (HP:0010819)	1.82453674
69	Excessive salivation (HP:0003781)	1.81804223
70	Drooling (HP:0002307)	1.81804223
71	Abnormality of cells of the erythroid lineage (HP:0012130)	1.80355855
72	Nasal speech (HP:0001611)	1.80154828
73	Arterial tortuosity (HP:0005116)	1.79550753
74	11 pairs of ribs (HP:0000878)	1.78650847
75	Metatarsus adductus (HP:0001840)	1.78304909
76	Mutism (HP:0002300)	1.77764937
77	Preaxial foot polydactyly (HP:0001841)	1.76445178
78	Enlarged kidneys (HP:0000105)	1.76083282
79	Exotropia (HP:0000577)	1.75336414
80	Venous insufficiency (HP:0005293)	1.74958564
81	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.73882178
82	Xanthomatosis (HP:0000991)	1.73601212
83	Hyperglycinuria (HP:0003108)	1.70926213
84	Femoral bowing (HP:0002980)	1.69502770
85	Seborrheic dermatitis (HP:0001051)	1.69392637
86	Thick nail (HP:0001805)	1.66992050
87	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.66613249
88	Hemiplegia (HP:0002301)	1.66363733
89	Abnormality of the clitoris (HP:0000056)	1.65278321
90	Overriding aorta (HP:0002623)	1.64236648
91	Action tremor (HP:0002345)	1.64026963
92	Fibular hypoplasia (HP:0003038)	1.62249106
93	Duplication of thumb phalanx (HP:0009942)	1.62114562
94	Peritonitis (HP:0002586)	1.61990113
95	Insulin-resistant diabetes mellitus (HP:0000831)	1.61861223
96	Abnormality of the pulmonary veins (HP:0011718)	1.61419998
97	Cerebral aneurysm (HP:0004944)	1.61309764
98	Vascular tortuosity (HP:0004948)	1.61079663
99	Generalized myoclonic seizures (HP:0002123)	1.60594631
100	Onion bulb formation (HP:0003383)	1.59480426

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	4.41544437
2	INSRR	3.95724025
3	BLK	3.75482043
4	MAPK15	3.03103197
5	NTRK1	2.84651857
6	PRKD3	2.80927343
7	NTRK2	2.77677119
8	PIK3CG	2.76821709
9	SIK2	2.41048246
10	ARAF	2.15847852
11	EPHB1	2.05852023
12	UHMK1	2.04219646
13	EIF2AK2	1.76081666
14	MAPKAPK5	1.73930382
15	TAOK1	1.70546050
16	MAPK13	1.70214499
17	MST1R	1.66915611
18	NTRK3	1.61836115
19	PNCK	1.57478397
20	MARK1	1.40585727
21	WNK4	1.39537303
22	TESK2	1.38690332
23	FRK	1.36441149
24	MAP3K13	1.34036039
25	ERN1	1.26755674
26	PKN1	1.25440797
27	MAP3K9	1.25189418
28	SIK1	1.22810728
29	EPHB2	1.20634163
30	TLK1	1.14632238
31	MOS	1.10855993
32	CASK	1.07976604
33	FGR	1.07911958
34	KSR2	1.03908117
35	DDR2	0.99255651
36	BRAF	0.95158975
37	DYRK2	0.91854329
38	NME1	0.91648399
39	PAK3	0.85974598
40	ADRBK1	0.85811798
41	MAP3K2	0.83230374
42	CAMK1G	0.82378893
43	ERBB2	0.78240176
44	PAK2	0.77224769
45	PHKG2	0.77160493
46	PHKG1	0.77160493
47	STK39	0.75370957
48	TTN	0.73633417
49	SGK223	0.73169751
50	SGK494	0.73169751
51	EEF2K	0.71900612
52	PTK2	0.69720508
53	EPHA3	0.68747802
54	CDC42BPA	0.68140390
55	MAP3K14	0.66273071
56	CDK5	0.65211142
57	MARK2	0.62771796
58	ITK	0.61800298
59	NME2	0.61686552
60	HIPK2	0.59235319
61	IRAK1	0.59217195
62	PTK6	0.58965104
63	TAOK3	0.58497120
64	WNK1	0.58121145
65	ROCK2	0.55668673
66	GRK1	0.55325456
67	OXSR1	0.52950565
68	EPHA2	0.52159895
69	CLK1	0.51941074
70	FGFR4	0.51327534
71	PDGFRA	0.47966531
72	CSNK1A1L	0.47709453
73	ADRBK2	0.45994426
74	KIT	0.45877183
75	TNIK	0.45535666
76	ALK	0.45340957
77	PRKD2	0.45326618
78	PRKCH	0.45319776
79	FES	0.44737417
80	FER	0.44443867
81	CDK15	0.44382556
82	ZAP70	0.44187473
83	MAP2K2	0.41490314
84	CAMK2B	0.40319317
85	SGK2	0.39852183
86	MAP3K8	0.38763757
87	CAMK2D	0.38012473
88	CAMK2A	0.37136489
89	PRKG1	0.37013267
90	CDK11A	0.36280082
91	PRKCG	0.36169325
92	PRKCQ	0.35457351
93	GSK3A	0.35428273
94	CDK18	0.35171700
95	PRKD1	0.34557734
96	LATS2	0.34491264
97	PIM2	0.34161030
98	ROCK1	0.34130365
99	INSR	0.33858211
100	MAP3K1	0.33714502

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.35155053
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.31581569
3	Ether lipid metabolism_Homo sapiens_hsa00565	2.08643197
4	ABC transporters_Homo sapiens_hsa02010	2.06554859
5	Insulin secretion_Homo sapiens_hsa04911	2.05244829
6	Butanoate metabolism_Homo sapiens_hsa00650	1.95671863
7	Prion diseases_Homo sapiens_hsa05020	1.81856519
8	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.76715133
9	Fatty acid elongation_Homo sapiens_hsa00062	1.74181105
10	GABAergic synapse_Homo sapiens_hsa04727	1.73429876
11	Glutamatergic synapse_Homo sapiens_hsa04724	1.70581412
12	Nicotine addiction_Homo sapiens_hsa05033	1.62066865
13	Type II diabetes mellitus_Homo sapiens_hsa04930	1.61797818
14	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.59927628
15	Ribosome_Homo sapiens_hsa03010	1.59253495
16	* Taste transduction_Homo sapiens_hsa04742	1.56034411
17	Axon guidance_Homo sapiens_hsa04360	1.51881596
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.47461029
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.46473713
20	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.41168342
21	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.38512344
22	Cocaine addiction_Homo sapiens_hsa05030	1.37385539
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.34026681
24	Serotonergic synapse_Homo sapiens_hsa04726	1.33264512
25	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.31362079
26	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.26442473
27	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.24591959
28	Fat digestion and absorption_Homo sapiens_hsa04975	1.23939505
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.23794465
30	Bile secretion_Homo sapiens_hsa04976	1.22929241
31	Histidine metabolism_Homo sapiens_hsa00340	1.21970628
32	Circadian entrainment_Homo sapiens_hsa04713	1.21870075
33	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.18595456
34	Mineral absorption_Homo sapiens_hsa04978	1.14394364
35	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.12388780
36	Complement and coagulation cascades_Homo sapiens_hsa04610	1.11556751
37	Long-term depression_Homo sapiens_hsa04730	1.10900249
38	PPAR signaling pathway_Homo sapiens_hsa03320	1.10833896
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.02846472
40	Renin secretion_Homo sapiens_hsa04924	1.01575858
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.01550321
42	GnRH signaling pathway_Homo sapiens_hsa04912	0.99665915
43	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.99008626
44	Morphine addiction_Homo sapiens_hsa05032	0.98749749
45	Gap junction_Homo sapiens_hsa04540	0.97750825
46	Dopaminergic synapse_Homo sapiens_hsa04728	0.95827122
47	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.93580433
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.92961222
49	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.92828295
50	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.91653347
51	Estrogen signaling pathway_Homo sapiens_hsa04915	0.90725450
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90217462
53	Phototransduction_Homo sapiens_hsa04744	0.89656539
54	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.89223750
55	Gastric acid secretion_Homo sapiens_hsa04971	0.88295932
56	Amphetamine addiction_Homo sapiens_hsa05031	0.88032956
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.87631517
58	Cholinergic synapse_Homo sapiens_hsa04725	0.86105840
59	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.85751236
60	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.85429948
61	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.82401139
62	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.79458513
63	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.78284801
64	Nitrogen metabolism_Homo sapiens_hsa00910	0.77722916
65	Sphingolipid metabolism_Homo sapiens_hsa00600	0.75573940
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.75324557
67	Arginine and proline metabolism_Homo sapiens_hsa00330	0.74824062
68	African trypanosomiasis_Homo sapiens_hsa05143	0.74068994
69	ECM-receptor interaction_Homo sapiens_hsa04512	0.73461274
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.73315189
71	Steroid biosynthesis_Homo sapiens_hsa00100	0.73267854
72	Melanogenesis_Homo sapiens_hsa04916	0.70059074
73	Salivary secretion_Homo sapiens_hsa04970	0.68995056
74	Peroxisome_Homo sapiens_hsa04146	0.68271634
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66410017
76	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.66265766
77	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.66121305
78	Long-term potentiation_Homo sapiens_hsa04720	0.65194893
79	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.62896276
80	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.62730395
81	Fatty acid metabolism_Homo sapiens_hsa01212	0.59322549
82	Protein digestion and absorption_Homo sapiens_hsa04974	0.57417757
83	Amoebiasis_Homo sapiens_hsa05146	0.56815513
84	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.55572768
85	Pancreatic secretion_Homo sapiens_hsa04972	0.55042896
86	Arginine biosynthesis_Homo sapiens_hsa00220	0.54634941
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.54298340
88	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.53958409
89	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.53098710
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51982146
91	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.51557886
92	cAMP signaling pathway_Homo sapiens_hsa04024	0.51005581
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.48722196
94	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48524771
95	Phenylalanine metabolism_Homo sapiens_hsa00360	0.48387517
96	Ras signaling pathway_Homo sapiens_hsa04014	0.47095233
97	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.46403081
98	Fatty acid degradation_Homo sapiens_hsa00071	0.46284820
99	Sulfur metabolism_Homo sapiens_hsa00920	0.46279816
100	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45626559

TAS1R2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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