TAS2R10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.12580974
2gamma-aminobutyric acid transport (GO:0015812)4.35808593
3neural tube formation (GO:0001841)4.27941420
4positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.01372522
5regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.01372522
6negative regulation of cytosolic calcium ion concentration (GO:0051481)3.89849763
7cell wall macromolecule catabolic process (GO:0016998)3.68956095
8DNA double-strand break processing (GO:0000729)3.64644612
9resolution of meiotic recombination intermediates (GO:0000712)3.56762165
10water-soluble vitamin biosynthetic process (GO:0042364)3.53700087
11keratinocyte development (GO:0003334)3.49682799
12intraciliary transport (GO:0042073)3.42405369
13presynaptic membrane assembly (GO:0097105)3.38789012
14retinal ganglion cell axon guidance (GO:0031290)3.32825813
15retinal cone cell development (GO:0046549)3.31496162
16regulation of cilium movement (GO:0003352)3.28954785
17mitotic sister chromatid cohesion (GO:0007064)3.26344225
18nonmotile primary cilium assembly (GO:0035058)3.19554435
19cilium morphogenesis (GO:0060271)3.19353199
20replication fork processing (GO:0031297)3.17396396
21regulation of male gonad development (GO:2000018)3.14057534
22establishment of protein localization to Golgi (GO:0072600)3.13076053
23regulation of synapse structural plasticity (GO:0051823)3.09577550
24axonal fasciculation (GO:0007413)3.07739716
25respiratory chain complex IV assembly (GO:0008535)3.06823991
26cellular response to ethanol (GO:0071361)3.03570588
27cell wall macromolecule metabolic process (GO:0044036)3.02624535
28cilium organization (GO:0044782)3.01273977
29mechanosensory behavior (GO:0007638)3.00697174
30G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97990298
31ether lipid metabolic process (GO:0046485)2.97808249
32cilium assembly (GO:0042384)2.96557486
33L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.95211583
34cytochrome complex assembly (GO:0017004)2.94169688
35limb bud formation (GO:0060174)2.93149296
36glycerol ether metabolic process (GO:0006662)2.90531348
37central nervous system neuron axonogenesis (GO:0021955)2.90068588
38central nervous system projection neuron axonogenesis (GO:0021952)2.88919862
39somite development (GO:0061053)2.88783143
40regulation of pigment cell differentiation (GO:0050932)2.88145011
41lactate metabolic process (GO:0006089)2.87768441
42dendritic spine morphogenesis (GO:0060997)2.87535627
43epithelial cilium movement (GO:0003351)2.86195041
44mitochondrial respiratory chain complex assembly (GO:0033108)2.85098718
45protein complex biogenesis (GO:0070271)2.84208754
46alanine transport (GO:0032328)2.83610376
47regulation of neuron projection regeneration (GO:0070570)2.82415351
48regulation of axon regeneration (GO:0048679)2.82415351
49establishment of nucleus localization (GO:0040023)2.82163482
50proline transport (GO:0015824)2.81224130
51NADH dehydrogenase complex assembly (GO:0010257)2.80797910
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80797910
53mitochondrial respiratory chain complex I assembly (GO:0032981)2.80797910
54otic vesicle formation (GO:0030916)2.80533875
55oocyte development (GO:0048599)2.78972741
56cyclic nucleotide catabolic process (GO:0009214)2.78066795
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.77010437
58C4-dicarboxylate transport (GO:0015740)2.76638651
59cAMP catabolic process (GO:0006198)2.76147734
60cellular ketone body metabolic process (GO:0046950)2.73869582
61cilium movement (GO:0003341)2.71216949
62protein targeting to Golgi (GO:0000042)2.71010438
63retinal rod cell development (GO:0046548)2.70127050
64glutamate receptor signaling pathway (GO:0007215)2.69380156
65smoothened signaling pathway (GO:0007224)2.68929650
66ether metabolic process (GO:0018904)2.68483162
67polyol catabolic process (GO:0046174)2.68476543
68positive regulation of developmental pigmentation (GO:0048087)2.66416625
69presynaptic membrane organization (GO:0097090)2.66128109
70detection of calcium ion (GO:0005513)2.65309016
71protein polyglutamylation (GO:0018095)2.65128607
72microtubule anchoring (GO:0034453)2.64750313
73auditory behavior (GO:0031223)2.63842028
74adult heart development (GO:0007512)2.62325836
75ionotropic glutamate receptor signaling pathway (GO:0035235)2.61521515
76cornea development in camera-type eye (GO:0061303)2.60215679
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.57537387
78negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.57535372
79negative regulation of translation, ncRNA-mediated (GO:0040033)2.57535372
80regulation of translation, ncRNA-mediated (GO:0045974)2.57535372
81negative regulation of protein localization to cell surface (GO:2000009)2.57350325
82regulation of DNA endoreduplication (GO:0032875)2.56957897
83meiotic chromosome segregation (GO:0045132)2.55913724
84cardiovascular system development (GO:0072358)2.55564206
85negative regulation of astrocyte differentiation (GO:0048712)2.55552519
86detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55246469
87embryonic epithelial tube formation (GO:0001838)2.53165861
88inositol phosphate catabolic process (GO:0071545)2.51825621
89tachykinin receptor signaling pathway (GO:0007217)2.51164750
90fucose catabolic process (GO:0019317)2.50619678
91L-fucose metabolic process (GO:0042354)2.50619678
92L-fucose catabolic process (GO:0042355)2.50619678
93cilium or flagellum-dependent cell motility (GO:0001539)2.50084484
94retrograde transport, vesicle recycling within Golgi (GO:0000301)2.49163331
95regulation of MHC class I biosynthetic process (GO:0045343)2.49084671
96synaptic transmission, glutamatergic (GO:0035249)2.47696382
97righting reflex (GO:0060013)2.47214096
98negative regulation of heart rate (GO:0010459)2.45332950
99positive regulation of vascular permeability (GO:0043117)2.45140218
100spinal cord development (GO:0021510)2.44905448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human3.42725904
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.33134734
3* POU3F2_20337985_ChIP-ChIP_501MEL_Human3.31831321
4ZFP57_27257070_Chip-Seq_ESCs_Mouse3.11014896
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.05555630
6TAF15_26573619_Chip-Seq_HEK293_Human2.90895172
7VDR_22108803_ChIP-Seq_LS180_Human2.86361187
8GBX2_23144817_ChIP-Seq_PC3_Human2.77359165
9ZNF274_21170338_ChIP-Seq_K562_Hela2.71830194
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.71431960
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.66580333
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.54375594
13P300_19829295_ChIP-Seq_ESCs_Human2.42507900
14FUS_26573619_Chip-Seq_HEK293_Human2.41364636
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38532700
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.30785875
17EWS_26573619_Chip-Seq_HEK293_Human2.29013317
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22706971
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08906074
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.05104405
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.98685357
22SMAD4_21799915_ChIP-Seq_A2780_Human1.92778476
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.86876873
24BCAT_22108803_ChIP-Seq_LS180_Human1.85411679
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83732461
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.83234975
27OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77314918
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.76478220
29SMAD3_21741376_ChIP-Seq_EPCs_Human1.73558060
30SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.68437201
31STAT3_23295773_ChIP-Seq_U87_Human1.66917747
32ER_23166858_ChIP-Seq_MCF-7_Human1.64988717
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59679171
34AR_25329375_ChIP-Seq_VCAP_Human1.57180977
35CBP_20019798_ChIP-Seq_JUKART_Human1.56826700
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56826700
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56030831
38KLF5_20875108_ChIP-Seq_MESCs_Mouse1.52610696
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50530965
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45812651
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.45448978
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44652665
43TCF4_23295773_ChIP-Seq_U87_Human1.43435438
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.41812365
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38162533
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38162533
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35187546
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31946080
49TCF4_22108803_ChIP-Seq_LS180_Human1.29821591
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29277665
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28415881
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28125361
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24849599
54CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.24068896
55FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24064733
56P53_22387025_ChIP-Seq_ESCs_Mouse1.23934788
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23504404
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22950932
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.22792123
60TAL1_26923725_Chip-Seq_HPCs_Mouse1.22558654
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22187370
62FLI1_21867929_ChIP-Seq_TH2_Mouse1.21570813
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21315649
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20593593
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.19281762
66RUNX2_22187159_ChIP-Seq_PCA_Human1.19202936
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19121720
68JUN_21703547_ChIP-Seq_K562_Human1.18720837
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18710933
70TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.15887376
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.15728181
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13297239
73ELK1_19687146_ChIP-ChIP_HELA_Human1.12264378
74TP53_16413492_ChIP-PET_HCT116_Human1.12230994
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.12089008
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11607060
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.11143330
78RNF2_27304074_Chip-Seq_NSC_Mouse1.10643795
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.09617505
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08753698
81SOX2_19829295_ChIP-Seq_ESCs_Human1.07548895
82NANOG_19829295_ChIP-Seq_ESCs_Human1.07548895
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.07103166
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.06677206
85MYC_18940864_ChIP-ChIP_HL60_Human1.06271323
86LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04350003
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04199221
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.04039925
89TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03577765
90TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03531194
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03349732
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02502227
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02372606
94SOX9_26525672_Chip-Seq_HEART_Mouse1.00556442
95STAT3_18555785_Chip-Seq_ESCs_Mouse1.00456315
96TP53_18474530_ChIP-ChIP_U2OS_Human0.99241853
97P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98219625
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97936680
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97874716
100HTT_18923047_ChIP-ChIP_STHdh_Human0.96800450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.71047231
2MP0003880_abnormal_central_pattern3.67839954
3MP0008057_abnormal_DNA_replication3.65647922
4MP0001529_abnormal_vocalization3.34997929
5MP0003136_yellow_coat_color2.82453545
6MP0002837_dystrophic_cardiac_calcinosis2.58282432
7MP0009046_muscle_twitch2.48807075
8MP0003195_calcinosis2.46978210
9MP0005645_abnormal_hypothalamus_physiol2.30635393
10MP0004142_abnormal_muscle_tone2.23864774
11MP0004147_increased_porphyrin_level2.14785168
12MP0006072_abnormal_retinal_apoptosis2.08125030
13MP0002736_abnormal_nociception_after2.04698309
14MP0005171_absent_coat_pigmentation2.01251531
15MP0000427_abnormal_hair_cycle1.94781213
16MP0004215_abnormal_myocardial_fiber1.92029073
17MP0001968_abnormal_touch/_nociception1.87185672
18MP0008058_abnormal_DNA_repair1.86171312
19MP0000778_abnormal_nervous_system1.81802426
20MP0001486_abnormal_startle_reflex1.76334879
21MP0005551_abnormal_eye_electrophysiolog1.74997480
22MP0000383_abnormal_hair_follicle1.71965710
23MP0005253_abnormal_eye_physiology1.71087537
24MP0002938_white_spotting1.70248183
25MP0002233_abnormal_nose_morphology1.66848106
26MP0004043_abnormal_pH_regulation1.61771479
27MP0009745_abnormal_behavioral_response1.60920702
28MP0002735_abnormal_chemical_nociception1.60888893
29MP0005646_abnormal_pituitary_gland1.55564058
30MP0008877_abnormal_DNA_methylation1.52809430
31MP0005367_renal/urinary_system_phenotyp1.51782278
32MP0000516_abnormal_urinary_system1.51782278
33MP0003890_abnormal_embryonic-extraembry1.50108747
34MP0003121_genomic_imprinting1.49903329
35MP0002272_abnormal_nervous_system1.43724056
36MP0006276_abnormal_autonomic_nervous1.34726731
37MP0003252_abnormal_bile_duct1.34444924
38MP0003787_abnormal_imprinting1.33315535
39MP0002557_abnormal_social/conspecific_i1.33167049
40MP0002184_abnormal_innervation1.32859195
41MP0000647_abnormal_sebaceous_gland1.32364301
42MP0003635_abnormal_synaptic_transmissio1.30895351
43MP0002653_abnormal_ependyma_morphology1.29502074
44MP0005386_behavior/neurological_phenoty1.28945580
45MP0004924_abnormal_behavior1.28945580
46MP0002064_seizures1.26387442
47MP0003221_abnormal_cardiomyocyte_apopto1.21049529
48MP0001485_abnormal_pinna_reflex1.20906265
49MP0002572_abnormal_emotion/affect_behav1.20555200
50MP0006035_abnormal_mitochondrial_morpho1.20378842
51MP0000372_irregular_coat_pigmentation1.18923596
52MP0000631_abnormal_neuroendocrine_gland1.17712139
53MP0004134_abnormal_chest_morphology1.17619151
54MP0002733_abnormal_thermal_nociception1.16259261
55MP0005266_abnormal_metabolism1.16197134
56MP0002332_abnormal_exercise_endurance1.15728645
57MP0003122_maternal_imprinting1.12438510
58MP0000955_abnormal_spinal_cord1.11771320
59MP0004133_heterotaxia1.10110404
60MP0010094_abnormal_chromosome_stability1.06682364
61MP0005195_abnormal_posterior_eye1.06307178
62MP0005187_abnormal_penis_morphology1.05837192
63MP0002638_abnormal_pupillary_reflex1.04074378
64MP0002909_abnormal_adrenal_gland1.02917351
65MP0001970_abnormal_pain_threshold1.02081729
66MP0005647_abnormal_sex_gland0.99212529
67MP0001984_abnormal_olfaction0.97784426
68MP0010678_abnormal_skin_adnexa0.96863408
69MP0008775_abnormal_heart_ventricle0.96312296
70MP0002095_abnormal_skin_pigmentation0.93090765
71MP0001440_abnormal_grooming_behavior0.92607350
72MP0000534_abnormal_ureter_morphology0.92472595
73MP0004859_abnormal_synaptic_plasticity0.90921559
74MP0002734_abnormal_mechanical_nocicepti0.90203344
75MP0002751_abnormal_autonomic_nervous0.89272628
76MP0003937_abnormal_limbs/digits/tail_de0.88504629
77MP0002067_abnormal_sensory_capabilities0.88495979
78MP0002752_abnormal_somatic_nervous0.88056783
79MP0005410_abnormal_fertilization0.87728706
80MP0002063_abnormal_learning/memory/cond0.85755322
81MP0001177_atelectasis0.84932790
82MP0003935_abnormal_craniofacial_develop0.84505658
83MP0001501_abnormal_sleep_pattern0.83033887
84MP0002876_abnormal_thyroid_physiology0.82205352
85MP0002229_neurodegeneration0.81421598
86MP0000538_abnormal_urinary_bladder0.80903977
87MP0002127_abnormal_cardiovascular_syste0.79910187
88MP0009703_decreased_birth_body0.79506636
89MP0005248_abnormal_Harderian_gland0.78761666
90MP0002882_abnormal_neuron_morphology0.77998384
91MP0000358_abnormal_cell_content/0.76893826
92MP0008961_abnormal_basal_metabolism0.75766918
93MP0001929_abnormal_gametogenesis0.75393408
94MP0009697_abnormal_copulation0.74992960
95MP0008789_abnormal_olfactory_epithelium0.74247493
96MP0003755_abnormal_palate_morphology0.73995361
97MP0003385_abnormal_body_wall0.71507596
98MP0005391_vision/eye_phenotype0.71033844
99MP0003698_abnormal_male_reproductive0.70249950
100MP0001324_abnormal_eye_pigmentation0.69700168

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.72816084
2Hyperventilation (HP:0002883)4.27306674
3Colon cancer (HP:0003003)3.49419566
4Abnormality of the labia minora (HP:0012880)3.46467095
5Unilateral renal agenesis (HP:0000122)3.39724592
6Abnormality of midbrain morphology (HP:0002418)3.18958668
7Molar tooth sign on MRI (HP:0002419)3.18958668
8True hermaphroditism (HP:0010459)3.08234589
9Broad-based gait (HP:0002136)2.99751225
10Medial flaring of the eyebrow (HP:0010747)2.98998246
11Aplasia/Hypoplasia of the tibia (HP:0005772)2.89732167
12Nephrogenic diabetes insipidus (HP:0009806)2.87064752
13Gaze-evoked nystagmus (HP:0000640)2.82734075
14Gait imbalance (HP:0002141)2.82385932
15Congenital primary aphakia (HP:0007707)2.78325077
163-Methylglutaconic aciduria (HP:0003535)2.77829905
17Septo-optic dysplasia (HP:0100842)2.76729988
18Aqueductal stenosis (HP:0002410)2.73870394
19Attenuation of retinal blood vessels (HP:0007843)2.68833785
20Birth length less than 3rd percentile (HP:0003561)2.64885459
21Pancreatic fibrosis (HP:0100732)2.57056594
22Bifid tongue (HP:0010297)2.54859773
23Pancreatic cysts (HP:0001737)2.53170559
24Papillary thyroid carcinoma (HP:0002895)2.51569575
25Increased hepatocellular lipid droplets (HP:0006565)2.50980542
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.50688997
27Hypoplastic labia majora (HP:0000059)2.49015545
28Widely spaced teeth (HP:0000687)2.48415230
29Renal cortical cysts (HP:0000803)2.44651029
30Sclerocornea (HP:0000647)2.41997925
31Lipid accumulation in hepatocytes (HP:0006561)2.39108463
32Acute necrotizing encephalopathy (HP:0006965)2.39094888
33Nephronophthisis (HP:0000090)2.32947838
34Decreased lacrimation (HP:0000633)2.31665470
35Progressive macrocephaly (HP:0004481)2.28819390
36Curly hair (HP:0002212)2.28425954
37Postaxial foot polydactyly (HP:0001830)2.28389690
38Genital tract atresia (HP:0001827)2.26385963
39Stomach cancer (HP:0012126)2.25728582
40Vaginal atresia (HP:0000148)2.24180513
41Protruding tongue (HP:0010808)2.23870834
42Abnormality of the labia majora (HP:0012881)2.22880138
43Preaxial hand polydactyly (HP:0001177)2.17250934
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.12323693
45Absent/shortened dynein arms (HP:0200106)2.12323693
46Abnormality of the renal cortex (HP:0011035)2.12291158
47Esophageal atresia (HP:0002032)2.11943293
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.00974565
49Microtia (HP:0008551)2.00723611
50Postaxial hand polydactyly (HP:0001162)1.99452624
51Lissencephaly (HP:0001339)1.99113643
52Intestinal atresia (HP:0011100)1.98945167
53Increased CSF lactate (HP:0002490)1.98441262
54Gastrointestinal atresia (HP:0002589)1.98114375
55Broad foot (HP:0001769)1.97417015
56Labial hypoplasia (HP:0000066)1.95947404
57Small hand (HP:0200055)1.95909825
58Abnormality of the ischium (HP:0003174)1.95087223
59Renal hypoplasia (HP:0000089)1.93488303
60Febrile seizures (HP:0002373)1.92449391
61Abnormality of the renal medulla (HP:0100957)1.91433737
62Atonic seizures (HP:0010819)1.90356084
63Abnormality of methionine metabolism (HP:0010901)1.89568734
64Glioma (HP:0009733)1.89117379
65Mitochondrial inheritance (HP:0001427)1.88543574
66Epidermoid cyst (HP:0200040)1.88304795
67Oligodactyly (hands) (HP:0001180)1.87762363
68Short foot (HP:0001773)1.86975671
69Astrocytoma (HP:0009592)1.85524008
70Abnormality of the astrocytes (HP:0100707)1.85524008
71Hypogonadotrophic hypogonadism (HP:0000044)1.85014382
72Astigmatism (HP:0000483)1.84916847
73Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84329188
74Abnormal mitochondria in muscle tissue (HP:0008316)1.84193025
75Sex reversal (HP:0012245)1.84062384
76Abnormal sex determination (HP:0012244)1.84062384
77Hemiparesis (HP:0001269)1.83791259
78Abnormal drinking behavior (HP:0030082)1.81739465
79Polydipsia (HP:0001959)1.81739465
80Cutaneous finger syndactyly (HP:0010554)1.81461820
81Methylmalonic acidemia (HP:0002912)1.79560002
82Male pseudohermaphroditism (HP:0000037)1.79201557
83High anterior hairline (HP:0009890)1.76365854
84Gastroesophageal reflux (HP:0002020)1.74495584
85Hypoplastic female external genitalia (HP:0012815)1.73376481
86Congenital stationary night blindness (HP:0007642)1.72153045
87Poor coordination (HP:0002370)1.72130032
88Renal Fanconi syndrome (HP:0001994)1.71545779
89Acute encephalopathy (HP:0006846)1.71010257
90Abnormality of cochlea (HP:0000375)1.69812504
91Rhabdomyosarcoma (HP:0002859)1.69803728
92Oligodactyly (HP:0012165)1.69729052
93Poor speech (HP:0002465)1.69410419
94Large earlobe (HP:0009748)1.68610697
95Median cleft lip (HP:0000161)1.68483556
96Hepatoblastoma (HP:0002884)1.68282370
97Abnormal ciliary motility (HP:0012262)1.66957669
98Neoplasm of the oral cavity (HP:0100649)1.66527407
99Narrow forehead (HP:0000341)1.66351146
100Bilateral sensorineural hearing impairment (HP:0008619)1.66036438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.25609704
2FRK5.04321128
3MAP4K25.02084957
4WNK33.11976932
5CAMK1G2.82697779
6CAMK1D2.79529501
7BMPR1B2.67264132
8BUB12.39734198
9TRIM282.32767862
10ACVR1B2.17264293
11PNCK2.09842923
12STK38L1.95453375
13CASK1.94018525
14FGFR21.88419680
15MAPK131.86904188
16MKNK21.79406413
17CAMKK21.79294591
18TNIK1.62165078
19PRKD31.61122716
20STK391.52849418
21IRAK21.48947948
22MKNK11.48868276
23EIF2AK11.47297406
24OXSR11.40667440
25STK161.39520717
26CSNK1G11.30611128
27CSNK1G21.25237746
28NEK91.23281792
29PAK31.22336053
30TAOK11.18314177
31NEK11.17142170
32EIF2AK31.15777920
33IRAK11.13865185
34WNK41.13495176
35ZAK1.11147604
36TAF11.03435306
37BCR1.02294361
38TGFBR11.01538470
39ERBB30.97145829
40NLK0.95548645
41PDK20.95005759
42MAP3K40.94882028
43CSNK1G30.94579785
44MINK10.85243400
45NTRK20.84549054
46CSNK1A1L0.78938247
47MST40.74035439
48CDK30.73134463
49GRK10.69172114
50PLK40.68847740
51PRKCG0.67719611
52BRD40.67150665
53ADRBK20.66075870
54PRKCE0.64178837
55MARK10.62016194
56NUAK10.57803185
57PKN10.56485199
58ATM0.55662842
59EPHB20.55356541
60PLK30.55315317
61PLK20.54747929
62MET0.53275788
63CAMK10.49632593
64NTRK30.48903611
65CAMK40.48550285
66PIK3CG0.46600573
67PLK10.45785410
68DYRK30.43960205
69SRPK10.43705979
70ADRBK10.40422586
71CAMK2A0.39982216
72DYRK1A0.39678747
73ATR0.39420945
74NEK20.39326021
75MAP2K70.38795000
76TRPM70.38729806
77INSRR0.37790690
78DAPK20.37356294
79FGFR10.36964257
80PRKD20.36218587
81PAK60.33251660
82AKT30.32688473
83FLT30.32323001
84OBSCN0.31088645
85SIK30.30722032
86KSR10.26098271
87PRKDC0.25939817
88SGK20.25773517
89EPHB10.24970849
90TGFBR20.24790820
91PRKG10.24616037
92CSNK1A10.23927070
93ROCK10.23752033
94TLK10.22677945
95PRKCZ0.21506908
96PRKACA0.20904073
97PBK0.20725724
98EIF2AK20.20492475
99CSNK1D0.20488633
100CSNK1E0.18807415

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.50248240
2Non-homologous end-joining_Homo sapiens_hsa034503.34917472
3Butanoate metabolism_Homo sapiens_hsa006503.03855814
4Steroid biosynthesis_Homo sapiens_hsa001002.56842853
5Vitamin B6 metabolism_Homo sapiens_hsa007502.49801164
6Basal transcription factors_Homo sapiens_hsa030222.31205853
7Selenocompound metabolism_Homo sapiens_hsa004502.22324639
8RNA polymerase_Homo sapiens_hsa030202.11216903
9Nitrogen metabolism_Homo sapiens_hsa009102.03859464
10Phototransduction_Homo sapiens_hsa047441.92118157
11Fanconi anemia pathway_Homo sapiens_hsa034601.85443230
12Nicotine addiction_Homo sapiens_hsa050331.81570751
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76805773
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.75629327
15* Taste transduction_Homo sapiens_hsa047421.59781579
16Regulation of autophagy_Homo sapiens_hsa041401.55494037
17Asthma_Homo sapiens_hsa053101.54846120
18Oxidative phosphorylation_Homo sapiens_hsa001901.49036109
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44373014
20Olfactory transduction_Homo sapiens_hsa047401.41013620
21TGF-beta signaling pathway_Homo sapiens_hsa043501.38715908
22Glutamatergic synapse_Homo sapiens_hsa047241.37966405
23Protein export_Homo sapiens_hsa030601.35568569
24Dorso-ventral axis formation_Homo sapiens_hsa043201.31775125
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30251410
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27847222
27GABAergic synapse_Homo sapiens_hsa047271.27670852
28Circadian rhythm_Homo sapiens_hsa047101.26993637
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26771184
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23244609
31Circadian entrainment_Homo sapiens_hsa047131.20772428
32Morphine addiction_Homo sapiens_hsa050321.16700240
33Amphetamine addiction_Homo sapiens_hsa050311.11105744
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08729693
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07440086
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.05687851
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05153292
38Sulfur metabolism_Homo sapiens_hsa009201.03416331
39Salivary secretion_Homo sapiens_hsa049701.01393246
40Insulin secretion_Homo sapiens_hsa049111.00905554
41Oocyte meiosis_Homo sapiens_hsa041140.99997273
42Huntingtons disease_Homo sapiens_hsa050160.99884395
43Chemical carcinogenesis_Homo sapiens_hsa052040.99570592
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.99289098
45Peroxisome_Homo sapiens_hsa041460.97614928
46Glycerolipid metabolism_Homo sapiens_hsa005610.97373731
47Caffeine metabolism_Homo sapiens_hsa002320.96413036
48Long-term depression_Homo sapiens_hsa047300.94985153
49Linoleic acid metabolism_Homo sapiens_hsa005910.90468045
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90236230
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.89809398
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85982134
53Dopaminergic synapse_Homo sapiens_hsa047280.85252931
54Propanoate metabolism_Homo sapiens_hsa006400.84431272
55Parkinsons disease_Homo sapiens_hsa050120.83436941
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83245565
57Renin secretion_Homo sapiens_hsa049240.82207878
58Ether lipid metabolism_Homo sapiens_hsa005650.79793426
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79279994
60Type I diabetes mellitus_Homo sapiens_hsa049400.78242951
61RNA degradation_Homo sapiens_hsa030180.77393714
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77092549
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75008933
64Homologous recombination_Homo sapiens_hsa034400.74518568
65Tryptophan metabolism_Homo sapiens_hsa003800.74004691
66Purine metabolism_Homo sapiens_hsa002300.73563787
67Sphingolipid metabolism_Homo sapiens_hsa006000.72658825
68Collecting duct acid secretion_Homo sapiens_hsa049660.71749250
69Calcium signaling pathway_Homo sapiens_hsa040200.69925524
70Fatty acid metabolism_Homo sapiens_hsa012120.69558460
71Axon guidance_Homo sapiens_hsa043600.67531695
72Retinol metabolism_Homo sapiens_hsa008300.67002689
73Cell cycle_Homo sapiens_hsa041100.65601222
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.64628156
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64307112
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64161178
77Fatty acid elongation_Homo sapiens_hsa000620.63541996
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63215290
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.60868470
80RNA transport_Homo sapiens_hsa030130.57309528
81Glutathione metabolism_Homo sapiens_hsa004800.56694622
82Lysine degradation_Homo sapiens_hsa003100.54108469
83Cardiac muscle contraction_Homo sapiens_hsa042600.51502097
84Wnt signaling pathway_Homo sapiens_hsa043100.51133094
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51084961
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50628225
87Cocaine addiction_Homo sapiens_hsa050300.49323122
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48506918
89Nucleotide excision repair_Homo sapiens_hsa034200.46755252
90Ovarian steroidogenesis_Homo sapiens_hsa049130.45339695
91ABC transporters_Homo sapiens_hsa020100.45116703
92Alzheimers disease_Homo sapiens_hsa050100.43492429
93Hedgehog signaling pathway_Homo sapiens_hsa043400.42724274
94cAMP signaling pathway_Homo sapiens_hsa040240.41711115
95Oxytocin signaling pathway_Homo sapiens_hsa049210.41547020
96beta-Alanine metabolism_Homo sapiens_hsa004100.41120907
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40357485
98Pyrimidine metabolism_Homo sapiens_hsa002400.40182313
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39647258
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38424432

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