TAS2R13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urinary tract smooth muscle contraction (GO:0014848)9.15524605
2drinking behavior (GO:0042756)8.55469243
3regulation of uterine smooth muscle contraction (GO:0070472)8.20798540
4aggressive behavior (GO:0002118)8.00447413
5positive regulation of digestive system process (GO:0060456)7.91717048
6response to auditory stimulus (GO:0010996)6.49198536
7positive regulation of synaptic transmission, GABAergic (GO:0032230)6.26945989
8regulation of action potential (GO:0098900)6.05209255
9righting reflex (GO:0060013)5.74007044
10diterpenoid biosynthetic process (GO:0016102)4.91096437
11behavioral response to pain (GO:0048266)4.85557330
12positive regulation of renal sodium excretion (GO:0035815)4.74459317
13regulation of synaptic transmission, GABAergic (GO:0032228)4.39767933
14cellular response to ethanol (GO:0071361)4.16951335
15cytoplasmic mRNA processing body assembly (GO:0033962)4.09147234
16nuclear pore complex assembly (GO:0051292)4.07158670
17terpenoid biosynthetic process (GO:0016114)4.02256691
18protein K11-linked deubiquitination (GO:0035871)3.87975461
19histone-serine phosphorylation (GO:0035404)3.86605668
20phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.78456340
21behavioral response to ethanol (GO:0048149)3.72998647
22negative regulation of osteoblast proliferation (GO:0033689)3.72830659
23establishment of protein localization to Golgi (GO:0072600)3.61546878
24negative regulation of neurotransmitter transport (GO:0051589)3.44817320
25regulation of establishment of cell polarity (GO:2000114)3.38020225
26negative regulation of smooth muscle cell differentiation (GO:0051151)3.36314194
27long-term memory (GO:0007616)3.35216058
28snRNA transcription (GO:0009301)3.31496079
29regulation of vascular permeability (GO:0043114)3.26642716
30protein targeting to Golgi (GO:0000042)3.25548248
31regulation of digestive system process (GO:0044058)3.25328638
32neural tube formation (GO:0001841)3.19565902
33nuclear pore organization (GO:0006999)3.16855890
34adult feeding behavior (GO:0008343)3.13265044
35retrograde transport, vesicle recycling within Golgi (GO:0000301)3.13002808
36G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.11182764
37microtubule anchoring (GO:0034453)3.08742787
38regulation of protein glycosylation (GO:0060049)3.08428375
39negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04836359
40smooth muscle contraction (GO:0006939)3.03851537
41interkinetic nuclear migration (GO:0022027)3.03433453
42monoubiquitinated protein deubiquitination (GO:0035520)3.03038937
43regulation of renal sodium excretion (GO:0035813)3.01543804
44RNA destabilization (GO:0050779)2.95743123
45retinal rod cell development (GO:0046548)2.93997083
46UDP-N-acetylglucosamine metabolic process (GO:0006047)2.90456269
47negative regulation of neurotransmitter secretion (GO:0046929)2.87878892
48prenylation (GO:0097354)2.87161103
49protein prenylation (GO:0018342)2.87161103
50adaptation of signaling pathway (GO:0023058)2.86430020
51retinal metabolic process (GO:0042574)2.86277120
52glycoprotein catabolic process (GO:0006516)2.85407859
53positive regulation of smooth muscle contraction (GO:0045987)2.85069964
54regulation of pigment cell differentiation (GO:0050932)2.84042952
55regulation of RNA export from nucleus (GO:0046831)2.80471215
56response to morphine (GO:0043278)2.79572741
57pore complex assembly (GO:0046931)2.77330644
58reflex (GO:0060004)2.75135329
59mitotic sister chromatid cohesion (GO:0007064)2.73795287
60protein targeting to lysosome (GO:0006622)2.70035263
61establishment of protein localization to vacuole (GO:0072666)2.70035263
62protein targeting to vacuole (GO:0006623)2.70035263
63regulation of energy homeostasis (GO:2000505)2.69728456
64regulation of establishment or maintenance of cell polarity (GO:0032878)2.68119649
65retinal cone cell development (GO:0046549)2.66807303
66hepatocyte apoptotic process (GO:0097284)2.65999168
67response to isoquinoline alkaloid (GO:0014072)2.64525579
68mRNA modification (GO:0016556)2.63728388
69positive regulation of developmental pigmentation (GO:0048087)2.61111899
70protein K48-linked deubiquitination (GO:0071108)2.60569335
71microtubule nucleation (GO:0007020)2.60563349
72nucleus localization (GO:0051647)2.60160997
73positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.59050848
74regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.59050848
75olfactory bulb development (GO:0021772)2.58466205
76response to methylmercury (GO:0051597)2.57132242
77positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.46044201
78positive regulation of blood pressure (GO:0045777)2.46034492
79lipid translocation (GO:0034204)2.43505171
80phospholipid translocation (GO:0045332)2.43505171
81regulation of excretion (GO:0044062)2.43355657
82membrane depolarization during action potential (GO:0086010)2.43045785
83pre-miRNA processing (GO:0031054)2.42447356
84eating behavior (GO:0042755)2.40246390
85protein localization to Golgi apparatus (GO:0034067)2.36832908
86replicative senescence (GO:0090399)2.36739360
87regulation of growth hormone secretion (GO:0060123)2.36701265
88negative regulation of DNA repair (GO:0045738)2.35716163
89protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.34124581
90labyrinthine layer development (GO:0060711)2.34011129
91acrosome reaction (GO:0007340)2.32296546
92auditory behavior (GO:0031223)2.32132192
93cell morphogenesis involved in neuron differentiation (GO:0048667)2.30267394
94histone mRNA catabolic process (GO:0071044)2.23095255
95regulation of mitochondrial depolarization (GO:0051900)2.22556803
96regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.20678177
97tachykinin receptor signaling pathway (GO:0007217)12.2358806
98positive regulation of action potential (GO:0045760)11.4530563
99positive regulation of uterine smooth muscle contraction (GO:0070474)10.4595338
100positive regulation of vascular permeability (GO:0043117)10.3930444

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.53316938
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.40713768
3GATA1_22025678_ChIP-Seq_K562_Human2.93784902
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.91045220
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.73423696
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.66602995
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.47438669
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.44365283
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.40623146
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34806500
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32339158
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30515097
13AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.30422989
14TAF15_26573619_Chip-Seq_HEK293_Human2.29974732
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23275365
16PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.05966712
17FUS_26573619_Chip-Seq_HEK293_Human2.03803881
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.02096505
19SMAD4_21799915_ChIP-Seq_A2780_Human1.98269453
20STAT3_23295773_ChIP-Seq_U87_Human1.90726186
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90301246
22P300_19829295_ChIP-Seq_ESCs_Human1.90094128
23IGF1R_20145208_ChIP-Seq_DFB_Human1.89435995
24EZH2_22144423_ChIP-Seq_EOC_Human1.88304585
25VDR_22108803_ChIP-Seq_LS180_Human1.84720685
26TP53_16413492_ChIP-PET_HCT116_Human1.83906499
27CBP_20019798_ChIP-Seq_JUKART_Human1.82490436
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.82490436
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81311744
30AR_21572438_ChIP-Seq_LNCaP_Human1.78335177
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.75924694
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75207607
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.74057400
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73982483
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72687581
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.71852387
37TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.68008518
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.63232365
39CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.60042723
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60035144
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58271281
42ER_23166858_ChIP-Seq_MCF-7_Human1.57692531
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55983646
44NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54930411
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54930411
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.54366845
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.53417836
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52109501
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49685427
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48393768
51EWS_26573619_Chip-Seq_HEK293_Human1.48121979
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47562424
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.45892723
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45304663
55AR_25329375_ChIP-Seq_VCAP_Human1.45088743
56E2F1_18555785_Chip-Seq_ESCs_Mouse1.44751577
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42194256
58ZNF274_21170338_ChIP-Seq_K562_Hela1.42023449
59TCF4_23295773_ChIP-Seq_U87_Human1.40778826
60PRDM14_20953172_ChIP-Seq_ESCs_Human1.37514015
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.35055604
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34254156
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33102323
64CRX_20693478_ChIP-Seq_RETINA_Mouse1.32521143
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30409830
66BCAT_22108803_ChIP-Seq_LS180_Human1.29714083
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29652179
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28602500
69TCF4_18268006_ChIP-ChIP_LS174T_Human1.27070767
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27053002
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25891375
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25891375
73TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.25620730
74OCT4_21477851_ChIP-Seq_ESCs_Mouse1.25077474
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24296358
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.23951124
77P53_22387025_ChIP-Seq_ESCs_Mouse1.23363627
78CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21283369
79SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.20606585
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19711443
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18934230
82AHR_22903824_ChIP-Seq_MCF-7_Human1.17882816
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.17413945
84RUNX2_22187159_ChIP-Seq_PCA_Human1.16994959
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16300463
86TCF4_22108803_ChIP-Seq_LS180_Human1.16056503
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15037996
88KDM2B_26808549_Chip-Seq_REH_Human1.15012946
89P300_18555785_Chip-Seq_ESCs_Mouse1.14697895
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.14495725
91TBL1_22424771_ChIP-Seq_293T_Human1.12718643
92KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12256192
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.11968410
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09648503
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.09311692
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08682620
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.08280700
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06872010
99RXR_22108803_ChIP-Seq_LS180_Human1.06395253
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05782916

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after6.16471142
2MP0000569_abnormal_digit_pigmentation6.12879895
3MP0001529_abnormal_vocalization4.91932668
4MP0001968_abnormal_touch/_nociception4.46849239
5MP0002735_abnormal_chemical_nociception4.25768353
6MP0008057_abnormal_DNA_replication4.02477049
7MP0002277_abnormal_respiratory_mucosa3.89299939
8MP0003183_abnormal_peptide_metabolism2.63473013
9MP0002009_preneoplasia2.60265115
10MP0003656_abnormal_erythrocyte_physiolo2.30826280
11MP0003787_abnormal_imprinting2.29977102
12MP0002734_abnormal_mechanical_nocicepti2.27380122
13MP0004270_analgesia2.26807267
14MP0009780_abnormal_chondrocyte_physiolo2.24746746
15MP0004145_abnormal_muscle_electrophysio1.94041711
16MP0002933_joint_inflammation1.76441664
17MP0005171_absent_coat_pigmentation1.75228057
18MP0003045_fibrosis1.71767404
19MP0003646_muscle_fatigue1.65182675
20MP0005386_behavior/neurological_phenoty1.64098108
21MP0004924_abnormal_behavior1.64098108
22MP0003890_abnormal_embryonic-extraembry1.51932874
23MP0002938_white_spotting1.48865614
24MP0000749_muscle_degeneration1.41468094
25MP0002163_abnormal_gland_morphology1.39727575
26MP0002067_abnormal_sensory_capabilities1.39460623
27MP0005174_abnormal_tail_pigmentation1.38759609
28MP0002168_other_aberrant_phenotype1.37437069
29MP0003633_abnormal_nervous_system1.36983579
30MP0000015_abnormal_ear_pigmentation1.29685322
31MP0000013_abnormal_adipose_tissue1.28934911
32MP0004142_abnormal_muscle_tone1.26883023
33MP0005367_renal/urinary_system_phenotyp1.25629112
34MP0000516_abnormal_urinary_system1.25629112
35MP0003631_nervous_system_phenotype1.25298442
36MP0003632_abnormal_nervous_system1.24573011
37MP0005379_endocrine/exocrine_gland_phen1.22835096
38MP0008872_abnormal_physiological_respon1.19655824
39MP0002166_altered_tumor_susceptibility1.18791747
40MP0004084_abnormal_cardiac_muscle1.17445292
41MP0004130_abnormal_muscle_cell1.16233699
42MP0004484_altered_response_of1.15247210
43MP0000778_abnormal_nervous_system1.15052731
44MP0005187_abnormal_penis_morphology1.09575815
45MP0003950_abnormal_plasma_membrane1.09079983
46MP0001661_extended_life_span1.04212737
47MP0001299_abnormal_eye_distance/1.02403601
48MP0010352_gastrointestinal_tract_polyps1.01722890
49MP0004036_abnormal_muscle_relaxation1.01489826
50MP0004859_abnormal_synaptic_plasticity0.97670224
51MP0008877_abnormal_DNA_methylation0.96456214
52MP0005551_abnormal_eye_electrophysiolog0.94683880
53MP0000371_diluted_coat_color0.92533773
54MP0003121_genomic_imprinting0.89406775
55MP0009745_abnormal_behavioral_response0.89388319
56MP0005395_other_phenotype0.89105600
57MP0000372_irregular_coat_pigmentation0.88656471
58MP0005623_abnormal_meninges_morphology0.84622548
59MP0003937_abnormal_limbs/digits/tail_de0.84075841
60MP0009697_abnormal_copulation0.83653905
61MP0010094_abnormal_chromosome_stability0.82373655
62MP0010307_abnormal_tumor_latency0.81103003
63MP0002095_abnormal_skin_pigmentation0.80385749
64MP0002909_abnormal_adrenal_gland0.80299807
65MP0005253_abnormal_eye_physiology0.80146330
66MP0003635_abnormal_synaptic_transmissio0.79672368
67MP0000383_abnormal_hair_follicle0.79616495
68MP0004381_abnormal_hair_follicle0.79534792
69MP0000427_abnormal_hair_cycle0.79301941
70MP0008058_abnormal_DNA_repair0.78138301
71MP0009046_muscle_twitch0.77752969
72MP0005408_hypopigmentation0.75981103
73MP0005248_abnormal_Harderian_gland0.75637904
74MP0005075_abnormal_melanosome_morpholog0.74700446
75MP0002751_abnormal_autonomic_nervous0.74543966
76MP0010678_abnormal_skin_adnexa0.73484896
77MP0001324_abnormal_eye_pigmentation0.73461666
78MP0002272_abnormal_nervous_system0.73380786
79MP0005310_abnormal_salivary_gland0.71952116
80MP0005220_abnormal_exocrine_pancreas0.71047299
81MP0000647_abnormal_sebaceous_gland0.69033931
82MP0002006_tumorigenesis0.67947768
83MP0001970_abnormal_pain_threshold0.67361434
84MP0003195_calcinosis0.66752810
85MP0003252_abnormal_bile_duct0.66427004
86MP0001177_atelectasis0.65262144
87MP0000631_abnormal_neuroendocrine_gland0.62091525
88MP0003172_abnormal_lysosome_physiology0.60906314
89MP0003329_amyloid_beta_deposits0.60846313
90MP0009703_decreased_birth_body0.60296080
91MP0006054_spinal_hemorrhage0.59779536
92MP0002332_abnormal_exercise_endurance0.58544348
93MP0006276_abnormal_autonomic_nervous0.56449283
94MP0005195_abnormal_posterior_eye0.56410433
95MP0004811_abnormal_neuron_physiology0.55670436
96MP0002572_abnormal_emotion/affect_behav0.55422069
97MP0001984_abnormal_olfaction0.53814251
98MP0003011_delayed_dark_adaptation0.53566872
99MP0002160_abnormal_reproductive_system0.52541737
100MP0003763_abnormal_thymus_physiology0.51551690

Predicted human phenotypes

RankGene SetZ-score
1Long clavicles (HP:0000890)4.69072627
2Asymmetry of the thorax (HP:0001555)3.70063254
3Broad ribs (HP:0000885)3.67062505
4Papillary thyroid carcinoma (HP:0002895)3.44849790
5Natal tooth (HP:0000695)3.37463125
6Gaze-evoked nystagmus (HP:0000640)3.24855798
7Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.22281399
8Short chin (HP:0000331)3.12795880
9Absent frontal sinuses (HP:0002688)3.11561063
10Cubitus valgus (HP:0002967)3.07441120
11Vertebral arch anomaly (HP:0008438)3.05332666
12Abnormality of the lumbar spine (HP:0100712)3.01913908
13Thyroiditis (HP:0100646)2.96669615
14Abnormality of chromosome stability (HP:0003220)2.88220502
15Wide intermamillary distance (HP:0006610)2.80153059
16T lymphocytopenia (HP:0005403)2.74491110
17Fair hair (HP:0002286)2.74303491
18Submucous cleft hard palate (HP:0000176)2.72223839
19Hyperventilation (HP:0002883)2.65929092
20Volvulus (HP:0002580)2.65842642
21Protruding tongue (HP:0010808)2.61382561
22Febrile seizures (HP:0002373)2.59159797
23Neonatal short-limb short stature (HP:0008921)2.55840241
24Widely spaced teeth (HP:0000687)2.50682362
25Abnormality of T cell number (HP:0011839)2.48818343
26Inappropriate behavior (HP:0000719)2.48757083
27Anal stenosis (HP:0002025)2.47815281
28Aqueductal stenosis (HP:0002410)2.46480369
29Facial cleft (HP:0002006)2.42063087
30Oligodactyly (hands) (HP:0001180)2.38624869
31Genetic anticipation (HP:0003743)2.37384289
32Acanthocytosis (HP:0001927)2.35128575
33Exotropia (HP:0000577)2.32141549
34Fibular aplasia (HP:0002990)2.31994976
35Thoracolumbar scoliosis (HP:0002944)2.31273449
36Thyroid carcinoma (HP:0002890)2.31119212
37Akinesia (HP:0002304)2.29980126
38Cystic hygroma (HP:0000476)2.29496800
39Partial agenesis of the corpus callosum (HP:0001338)2.29024068
40Dyschromatopsia (HP:0007641)2.25453520
41Fibular hypoplasia (HP:0003038)2.23256438
42Rhabdomyosarcoma (HP:0002859)2.22804834
43Chronic hepatic failure (HP:0100626)2.22059456
44Abnormality of the alveolar ridges (HP:0006477)2.20538873
45Intestinal atresia (HP:0011100)2.19889700
46Thyroid-stimulating hormone excess (HP:0002925)2.19088422
47Scotoma (HP:0000575)2.18939981
48Microtia (HP:0008551)2.18043917
49Hepatoblastoma (HP:0002884)2.16770199
50Diastasis recti (HP:0001540)2.10395915
51Arthropathy (HP:0003040)2.09223998
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.08323521
53Hip dysplasia (HP:0001385)2.08315631
54Scanning speech (HP:0002168)2.05600873
55Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.02304851
56Pancreatic cysts (HP:0001737)2.01216679
57Narrow forehead (HP:0000341)1.99807933
58Thickened calvaria (HP:0002684)1.98844528
59Atonic seizures (HP:0010819)1.98818452
60Generalized hypopigmentation of hair (HP:0011358)1.97944820
61Gait imbalance (HP:0002141)1.97179645
62Bifid tongue (HP:0010297)1.96630474
63Drooling (HP:0002307)1.94993384
64Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.94811415
65Blue irides (HP:0000635)1.94144540
66Abnormality of the sella turcica (HP:0002679)1.91063717
67Medulloblastoma (HP:0002885)1.89316195
68Astigmatism (HP:0000483)1.87839898
69Focal seizures (HP:0007359)1.86113942
70Sandal gap (HP:0001852)1.85588983
71Clubbing of toes (HP:0100760)1.85529106
72Hypoproteinemia (HP:0003075)1.84740759
73Advanced eruption of teeth (HP:0006288)1.83413790
74Slow saccadic eye movements (HP:0000514)1.83175686
75Recurrent bronchitis (HP:0002837)1.82880391
76Postaxial foot polydactyly (HP:0001830)1.81918660
77Cupped ear (HP:0000378)1.80779763
78Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.79994161
79Astrocytoma (HP:0009592)1.79324797
80Abnormality of the astrocytes (HP:0100707)1.79324797
81Truncal ataxia (HP:0002078)1.78418904
82Periodontitis (HP:0000704)1.78358657
83Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77825742
84Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.77245672
85Short 1st metacarpal (HP:0010034)1.77245672
86Tubulointerstitial nephritis (HP:0001970)1.76514340
87Abnormality of the ischium (HP:0003174)1.76300428
88Polyphagia (HP:0002591)1.75488331
89Excessive salivation (HP:0003781)1.75212776
90Limited hip movement (HP:0008800)1.75208776
91Midline defect of the nose (HP:0004122)1.73338789
92Medial flaring of the eyebrow (HP:0010747)1.72911378
93Hypothermia (HP:0002045)1.72293393
94Decreased lacrimation (HP:0000633)1.72052039
95Pancreatic fibrosis (HP:0100732)1.71929277
96Amyotrophic lateral sclerosis (HP:0007354)1.70417466
97Posterior subcapsular cataract (HP:0007787)1.70388431
98Aplasia/Hypoplasia of the scapulae (HP:0006713)1.69702115
99Hypoplastic scapulae (HP:0000882)1.69702115
100Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.67753802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK135.00866244
2FRK4.46934613
3CAMKK23.03839829
4TNIK2.77013082
5ACVR1B2.45203904
6AKT32.41782102
7BRSK22.24289302
8MUSK2.21363565
9SGK22.13485901
10MARK12.11022519
11MAP3K22.09642952
12CASK1.88567818
13MAP3K41.76453797
14CDK121.75346541
15MKNK21.73977382
16STK241.69811490
17WNK31.67314743
18STK38L1.55101536
19NEK91.51941747
20TRPM71.45009326
21OBSCN1.41580081
22SGK31.40296008
23BRD41.38970398
24DYRK1A1.32225996
25BCR1.31411324
26BMPR1B1.30661613
27SGK11.27706076
28NUAK11.26936336
29BMPR21.21562561
30NLK1.18265428
31LATS11.16851053
32BLK1.14453019
33SGK4941.12564823
34SGK2231.12564823
35PIK3CG1.11901731
36PAK31.10852180
37PLK21.10292523
38PHKG11.09184503
39PHKG21.09184503
40TGFBR21.07656241
41MKNK11.05764175
42MARK21.02804993
43NTRK31.02442661
44PTK2B1.00299520
45STK110.99859673
46ERBB30.99466742
47CAMK1G0.95957426
48KSR10.93986542
49TEC0.92596156
50ZAK0.91822358
51STK30.88982233
52RPS6KB10.87465862
53MAP3K60.85327878
54CAMK1D0.82851378
55EIF2AK20.81122831
56FGR0.80314294
57PRKAA20.74392948
58CAMKK10.72333579
59GRK50.71405870
60PRKAA10.68174018
61CAMK40.67110367
62FER0.65023061
63ADRBK10.61509555
64MAP4K20.58298344
65GRK70.58066430
66FGFR30.57046818
67IRAK10.56600955
68TAOK30.55076735
69FGFR10.54799521
70STK40.53369707
71PKN10.51627383
72CSNK1D0.50463944
73SYK0.49957143
74CAMK2B0.46023473
75PRKCE0.45483402
76FGFR20.44119779
77PRKCZ0.43959151
78RET0.43924013
79CHEK20.43491995
80WNK10.42515688
81MAP2K40.41918949
82CAMK2A0.41413578
83IKBKE0.40262986
84MAP3K70.38396461
85PRKCG0.38059347
86JAK10.37969085
87ATM0.37523915
88YES10.37326491
89PRKACB0.35368167
90PDGFRB0.34718794
91CSNK1A1L0.34612798
92RAF10.32521487
93CAMK2D0.31943106
94CSNK1G10.30454866
95CSNK1G20.30298704
96RPS6KA30.29798338
97GSK3A0.28582171
98DDR20.27296872
99EIF2AK30.26187883
100CAMK10.25436669

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.40393014
2ABC transporters_Homo sapiens_hsa020102.25867297
3Circadian rhythm_Homo sapiens_hsa047102.18732684
4Type II diabetes mellitus_Homo sapiens_hsa049302.14914798
5Glutamatergic synapse_Homo sapiens_hsa047242.14129018
6* Taste transduction_Homo sapiens_hsa047421.92673907
7Calcium signaling pathway_Homo sapiens_hsa040201.86062936
8Dorso-ventral axis formation_Homo sapiens_hsa043201.81808123
9Systemic lupus erythematosus_Homo sapiens_hsa053221.72257357
10Fanconi anemia pathway_Homo sapiens_hsa034601.59185120
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58311361
12Phosphatidylinositol signaling system_Homo sapiens_hsa040701.56494003
13Long-term depression_Homo sapiens_hsa047301.51898616
14Propanoate metabolism_Homo sapiens_hsa006401.43192444
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38808880
16Inositol phosphate metabolism_Homo sapiens_hsa005621.36547539
17Nicotine addiction_Homo sapiens_hsa050331.34487084
18Alcoholism_Homo sapiens_hsa050341.33874954
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29492766
20Long-term potentiation_Homo sapiens_hsa047201.25823927
21Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.25479830
22Glioma_Homo sapiens_hsa052141.23737659
23Lysine degradation_Homo sapiens_hsa003101.23727026
24Non-small cell lung cancer_Homo sapiens_hsa052231.22638462
25Circadian entrainment_Homo sapiens_hsa047131.19871761
26MicroRNAs in cancer_Homo sapiens_hsa052061.18843445
27FoxO signaling pathway_Homo sapiens_hsa040681.12996236
28Cholinergic synapse_Homo sapiens_hsa047251.04993311
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04866599
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03617313
31Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02742395
32Endometrial cancer_Homo sapiens_hsa052131.02089382
33ErbB signaling pathway_Homo sapiens_hsa040120.99417961
34Prolactin signaling pathway_Homo sapiens_hsa049170.99088502
35Renin secretion_Homo sapiens_hsa049240.98168221
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94211453
37Measles_Homo sapiens_hsa051620.94127217
38Choline metabolism in cancer_Homo sapiens_hsa052310.93955745
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89179986
40mTOR signaling pathway_Homo sapiens_hsa041500.89099243
41Platelet activation_Homo sapiens_hsa046110.88679541
42Prostate cancer_Homo sapiens_hsa052150.87760790
43Oxytocin signaling pathway_Homo sapiens_hsa049210.87179331
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87023993
45Adherens junction_Homo sapiens_hsa045200.86583007
46Melanoma_Homo sapiens_hsa052180.86438972
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86024230
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.85992234
49TGF-beta signaling pathway_Homo sapiens_hsa043500.84784323
50Renal cell carcinoma_Homo sapiens_hsa052110.84106611
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78111939
52Gap junction_Homo sapiens_hsa045400.77853977
53Ether lipid metabolism_Homo sapiens_hsa005650.77563396
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.77047422
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.76006910
56MAPK signaling pathway_Homo sapiens_hsa040100.74377862
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72803621
58Morphine addiction_Homo sapiens_hsa050320.71659948
59Insulin resistance_Homo sapiens_hsa049310.71286765
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.69776878
61Dopaminergic synapse_Homo sapiens_hsa047280.69709817
62cAMP signaling pathway_Homo sapiens_hsa040240.68425682
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67999693
64Regulation of autophagy_Homo sapiens_hsa041400.67027970
65Butanoate metabolism_Homo sapiens_hsa006500.66835031
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66350777
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65519776
68Axon guidance_Homo sapiens_hsa043600.65486438
69GnRH signaling pathway_Homo sapiens_hsa049120.65486270
70Basal transcription factors_Homo sapiens_hsa030220.65198702
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65022297
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.64973745
73Viral carcinogenesis_Homo sapiens_hsa052030.64759748
74Serotonergic synapse_Homo sapiens_hsa047260.64164841
75B cell receptor signaling pathway_Homo sapiens_hsa046620.63423612
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62273344
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.61952807
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60895718
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59480212
80Dilated cardiomyopathy_Homo sapiens_hsa054140.59190044
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59173666
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58969282
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57773271
84Homologous recombination_Homo sapiens_hsa034400.56633724
85Colorectal cancer_Homo sapiens_hsa052100.55665076
86Ras signaling pathway_Homo sapiens_hsa040140.54966599
87T cell receptor signaling pathway_Homo sapiens_hsa046600.53612784
88Pancreatic cancer_Homo sapiens_hsa052120.53200915
89RNA degradation_Homo sapiens_hsa030180.52720237
90GABAergic synapse_Homo sapiens_hsa047270.52416857
91Retinol metabolism_Homo sapiens_hsa008300.50990544
92Small cell lung cancer_Homo sapiens_hsa052220.50378966
93Proteoglycans in cancer_Homo sapiens_hsa052050.50154276
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49763583
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49673591
96Salivary secretion_Homo sapiens_hsa049700.49521772
97Pancreatic secretion_Homo sapiens_hsa049720.48373106
98Thyroid cancer_Homo sapiens_hsa052160.48127733
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46115817
100Olfactory transduction_Homo sapiens_hsa047400.45400194

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