TAS2R14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mitotic spindle checkpoint (GO:1903504)6.03779350
2regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)6.03779350
3attachment of spindle microtubules to kinetochore (GO:0008608)5.90898129
4neuron cell-cell adhesion (GO:0007158)5.37006121
5neural tube formation (GO:0001841)4.72055574
6microtubule anchoring (GO:0034453)4.67831940
7protein neddylation (GO:0045116)4.45786672
8nuclear pore organization (GO:0006999)4.35595396
9regulation of centrosome duplication (GO:0010824)4.30813865
10positive regulation of cell cycle checkpoint (GO:1901978)4.08851267
11DNA double-strand break processing (GO:0000729)3.78746908
12presynaptic membrane assembly (GO:0097105)3.76310098
13regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.74166171
14behavioral response to ethanol (GO:0048149)3.69078526
15positive regulation of mitochondrial fission (GO:0090141)3.57583819
16nuclear pore complex assembly (GO:0051292)3.55456505
17neurotransmitter-gated ion channel clustering (GO:0072578)3.54555796
18replication fork processing (GO:0031297)3.48532584
19regulation of centrosome cycle (GO:0046605)3.47222669
20presynaptic membrane organization (GO:0097090)3.43073980
21pyrimidine nucleobase catabolic process (GO:0006208)3.40179783
22microtubule nucleation (GO:0007020)3.36393316
23head development (GO:0060322)3.35848212
24postsynaptic membrane organization (GO:0001941)3.32283622
25sympathetic nervous system development (GO:0048485)3.29866558
26negative regulation of translation, ncRNA-mediated (GO:0040033)3.27537622
27regulation of translation, ncRNA-mediated (GO:0045974)3.27537622
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.27537622
29behavioral response to nicotine (GO:0035095)3.25833350
30L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.22531311
31methionine biosynthetic process (GO:0009086)3.20435424
32negative regulation of neurotransmitter transport (GO:0051589)3.13147499
33protein prenylation (GO:0018342)3.11504075
34prenylation (GO:0097354)3.11504075
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.11010418
36negative regulation of cAMP-mediated signaling (GO:0043951)3.05705510
37regulation of spindle checkpoint (GO:0090231)3.05315945
38phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.02211722
39histone mRNA catabolic process (GO:0071044)2.98898351
40proteasome assembly (GO:0043248)2.98109935
41centriole replication (GO:0007099)2.97105979
42positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.96557495
43pore complex assembly (GO:0046931)2.93437625
44positive regulation of growth hormone secretion (GO:0060124)2.92986300
45DNA demethylation (GO:0080111)2.92232650
46mitotic sister chromatid cohesion (GO:0007064)2.86169735
47recombinational repair (GO:0000725)2.85405349
48nucleobase catabolic process (GO:0046113)2.85384663
49negative regulation of DNA recombination (GO:0045910)2.83869334
50forebrain neuron differentiation (GO:0021879)2.82547451
51positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.82218564
52regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.82218564
53regulation of centriole replication (GO:0046599)2.82006329
54double-strand break repair via homologous recombination (GO:0000724)2.81267961
55regulation of DNA endoreduplication (GO:0032875)2.80664069
56microtubule severing (GO:0051013)2.75221798
57atrial cardiac muscle cell action potential (GO:0086014)2.74611942
58establishment of mitochondrion localization (GO:0051654)2.70708680
59methionine metabolic process (GO:0006555)2.70641002
60mitotic spindle assembly checkpoint (GO:0007094)2.70485079
61amino acid salvage (GO:0043102)2.70008362
62L-methionine salvage (GO:0071267)2.70008362
63L-methionine biosynthetic process (GO:0071265)2.70008362
64mitotic spindle checkpoint (GO:0071174)2.69371442
65negative regulation of mitotic sister chromatid separation (GO:2000816)2.68512864
66negative regulation of sister chromatid segregation (GO:0033046)2.68512864
67negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.68512864
68negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.68512864
69negative regulation of mitotic sister chromatid segregation (GO:0033048)2.68512864
70photoreceptor cell maintenance (GO:0045494)2.68428267
71spindle assembly checkpoint (GO:0071173)2.67048607
72peroxisome fission (GO:0016559)2.65877388
73negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62731856
74spindle checkpoint (GO:0031577)2.61710736
75folic acid-containing compound biosynthetic process (GO:0009396)2.61303743
76regulation of nuclear cell cycle DNA replication (GO:0033262)2.60220389
77postreplication repair (GO:0006301)2.59922383
78retina layer formation (GO:0010842)2.59056856
79negative regulation of chromosome segregation (GO:0051985)2.57762360
80nonmotile primary cilium assembly (GO:0035058)2.56055154
81water-soluble vitamin biosynthetic process (GO:0042364)2.55105614
82negative regulation of protein localization to cell surface (GO:2000009)2.54568652
83aspartate family amino acid biosynthetic process (GO:0009067)2.53433068
84RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53313173
85DNA dealkylation (GO:0035510)2.51750361
86maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.51674697
87regulation of growth hormone secretion (GO:0060123)2.50473282
88microtubule organizing center organization (GO:0031023)2.49547106
89regulation of mitotic metaphase/anaphase transition (GO:0030071)2.49055683
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.49055683
91protein localization to cilium (GO:0061512)2.47895288
92cullin deneddylation (GO:0010388)2.47300974
93organelle disassembly (GO:1903008)2.46449573
94histone H3-K4 trimethylation (GO:0080182)2.46037708
95regulation of Golgi to plasma membrane protein transport (GO:0042996)2.45897444
96regulation of mitotic sister chromatid separation (GO:0010965)2.44508481
97regulation of mitotic sister chromatid segregation (GO:0033047)2.44508481
98regulation of sister chromatid segregation (GO:0033045)2.44508481
99regulation of glutamate receptor signaling pathway (GO:1900449)2.44278803
100positive regulation of cAMP-mediated signaling (GO:0043950)2.43999493

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.64395352
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.32567952
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.24751929
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.99925436
5GBX2_23144817_ChIP-Seq_PC3_Human2.91878020
6IRF1_19129219_ChIP-ChIP_H3396_Human2.87686728
7ZNF274_21170338_ChIP-Seq_K562_Hela2.84025676
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82719553
9EWS_26573619_Chip-Seq_HEK293_Human2.55238879
10FUS_26573619_Chip-Seq_HEK293_Human2.28400860
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.26779584
12IGF1R_20145208_ChIP-Seq_DFB_Human2.25744095
13VDR_22108803_ChIP-Seq_LS180_Human2.23492951
14TAF15_26573619_Chip-Seq_HEK293_Human2.19783685
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17535982
16EZH2_22144423_ChIP-Seq_EOC_Human1.99674086
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98768651
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98198479
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.97219490
20P300_19829295_ChIP-Seq_ESCs_Human1.95427906
21OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.90779399
22ELK1_19687146_ChIP-ChIP_HELA_Human1.84357395
23MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.83663121
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81830884
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81146276
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79636598
27SMAD4_21799915_ChIP-Seq_A2780_Human1.78634905
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76606540
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71333133
30STAT3_23295773_ChIP-Seq_U87_Human1.68003330
31ER_23166858_ChIP-Seq_MCF-7_Human1.67644936
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67538845
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66777343
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.65153503
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64906967
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64715092
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61377938
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57673978
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57354791
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.56821364
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55308143
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54319588
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53364201
44CBP_20019798_ChIP-Seq_JUKART_Human1.53364201
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52705007
46EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.48904857
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.46368480
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45394688
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43902178
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41615480
51VDR_23849224_ChIP-Seq_CD4+_Human1.39410889
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38367720
53P53_22387025_ChIP-Seq_ESCs_Mouse1.37701455
54KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32479575
55FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.32313467
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.32283289
57TP53_22573176_ChIP-Seq_HFKS_Human1.31441300
58E2F1_18555785_Chip-Seq_ESCs_Mouse1.31170152
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28957846
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28599466
61TCF4_23295773_ChIP-Seq_U87_Human1.28381084
62AR_21572438_ChIP-Seq_LNCaP_Human1.28157701
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.27382850
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.26332431
65TCF4_22108803_ChIP-Seq_LS180_Human1.26025124
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.25662421
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25286921
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22966003
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22892710
70AR_25329375_ChIP-Seq_VCAP_Human1.22139006
71CMYC_18555785_Chip-Seq_ESCs_Mouse1.21454476
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21252036
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.19246828
74EST1_17652178_ChIP-ChIP_JURKAT_Human1.19142557
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19032221
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.18807029
77RUNX2_22187159_ChIP-Seq_PCA_Human1.18459268
78P300_18555785_Chip-Seq_ESCs_Mouse1.17783757
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16976301
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.15833283
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14976914
82MYC_18940864_ChIP-ChIP_HL60_Human1.13871045
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.13677823
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.13530151
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.13520400
86JUN_21703547_ChIP-Seq_K562_Human1.12175399
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09824335
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08364712
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06518795
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04786442
91OCT4_18555785_Chip-Seq_ESCs_Mouse1.04560220
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03080869
93SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02467723
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01981148
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01981148
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01746351
97BCAT_22108803_ChIP-Seq_LS180_Human1.00253244
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99166209
99OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98653922
100REST_21632747_ChIP-Seq_MESCs_Mouse0.98568728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.08700735
2MP0003890_abnormal_embryonic-extraembry3.67475234
3MP0008058_abnormal_DNA_repair3.18741054
4MP0003787_abnormal_imprinting3.16814403
5MP0003880_abnormal_central_pattern3.12877362
6MP0008877_abnormal_DNA_methylation2.94850867
7MP0006276_abnormal_autonomic_nervous2.69531455
8MP0002102_abnormal_ear_morphology2.55764333
9MP0001984_abnormal_olfaction2.39886762
10MP0001968_abnormal_touch/_nociception2.34300527
11MP0005423_abnormal_somatic_nervous2.34245871
12MP0004859_abnormal_synaptic_plasticity2.27464818
13MP0002736_abnormal_nociception_after2.14198438
14MP0001188_hyperpigmentation2.11637181
15MP0003122_maternal_imprinting2.02539439
16MP0003121_genomic_imprinting2.00894205
17MP0006035_abnormal_mitochondrial_morpho1.91377964
18MP0005645_abnormal_hypothalamus_physiol1.86017577
19MP0000569_abnormal_digit_pigmentation1.79765899
20MP0004742_abnormal_vestibular_system1.76610573
21MP0006292_abnormal_olfactory_placode1.74738045
22MP0003635_abnormal_synaptic_transmissio1.73358321
23MP0001529_abnormal_vocalization1.72878453
24MP0005084_abnormal_gallbladder_morpholo1.71813694
25MP0000778_abnormal_nervous_system1.47196202
26MP0001293_anophthalmia1.47077067
27MP0003252_abnormal_bile_duct1.46590069
28MP0004133_heterotaxia1.46488797
29MP0004885_abnormal_endolymph1.45502973
30MP0002735_abnormal_chemical_nociception1.44842731
31MP0000631_abnormal_neuroendocrine_gland1.43855798
32MP0002234_abnormal_pharynx_morphology1.43789015
33MP0004145_abnormal_muscle_electrophysio1.41181562
34MP0004215_abnormal_myocardial_fiber1.40958152
35MP0005551_abnormal_eye_electrophysiolog1.40406736
36MP0003646_muscle_fatigue1.35689231
37MP0002837_dystrophic_cardiac_calcinosis1.32231805
38MP0002272_abnormal_nervous_system1.31310468
39MP0002063_abnormal_learning/memory/cond1.30474447
40MP0002909_abnormal_adrenal_gland1.28936895
41MP0006036_abnormal_mitochondrial_physio1.26053583
42MP0002557_abnormal_social/conspecific_i1.25427164
43MP0009046_muscle_twitch1.23912235
44MP0004811_abnormal_neuron_physiology1.22671564
45MP0005266_abnormal_metabolism1.22033949
46MP0006072_abnormal_retinal_apoptosis1.21493332
47MP0008775_abnormal_heart_ventricle1.20218351
48MP0002067_abnormal_sensory_capabilities1.19475053
49MP0004084_abnormal_cardiac_muscle1.17159727
50MP0004270_analgesia1.16519992
51MP0001486_abnormal_startle_reflex1.16513026
52MP0004142_abnormal_muscle_tone1.16117328
53MP0005253_abnormal_eye_physiology1.15810048
54MP0002572_abnormal_emotion/affect_behav1.12598402
55MP0000358_abnormal_cell_content/1.07062826
56MP0010386_abnormal_urinary_bladder1.06419272
57MP0009745_abnormal_behavioral_response1.06289985
58MP0010094_abnormal_chromosome_stability1.06138856
59MP0002184_abnormal_innervation1.05040419
60MP0004134_abnormal_chest_morphology1.02715939
61MP0003077_abnormal_cell_cycle1.00401325
62MP0002734_abnormal_mechanical_nocicepti0.97677050
63MP0003119_abnormal_digestive_system0.97143994
64MP0002233_abnormal_nose_morphology0.97027476
65MP0002095_abnormal_skin_pigmentation0.96950672
66MP0005386_behavior/neurological_phenoty0.96738957
67MP0004924_abnormal_behavior0.96738957
68MP0009697_abnormal_copulation0.96548728
69MP0001970_abnormal_pain_threshold0.94706076
70MP0000647_abnormal_sebaceous_gland0.91373401
71MP0001286_abnormal_eye_development0.91243014
72MP0002177_abnormal_outer_ear0.90888736
73MP0003786_premature_aging0.89223453
74MP0003221_abnormal_cardiomyocyte_apopto0.89210123
75MP0000049_abnormal_middle_ear0.88902986
76MP0009764_decreased_sensitivity_to0.88639977
77MP0002752_abnormal_somatic_nervous0.87948674
78MP0005195_abnormal_posterior_eye0.87779352
79MP0005379_endocrine/exocrine_gland_phen0.87328974
80MP0002751_abnormal_autonomic_nervous0.85641661
81MP0000955_abnormal_spinal_cord0.84810360
82MP0004147_increased_porphyrin_level0.82026913
83MP0001299_abnormal_eye_distance/0.81025100
84MP0008932_abnormal_embryonic_tissue0.80626560
85MP0002152_abnormal_brain_morphology0.80466563
86MP0002882_abnormal_neuron_morphology0.80273316
87MP0008770_decreased_survivor_rate0.80039325
88MP0005187_abnormal_penis_morphology0.78457411
89MP0009703_decreased_birth_body0.78365810
90MP0003698_abnormal_male_reproductive0.76990466
91MP0005499_abnormal_olfactory_system0.75085966
92MP0005394_taste/olfaction_phenotype0.75085966
93MP0002733_abnormal_thermal_nociception0.74156701
94MP0001119_abnormal_female_reproductive0.73776616
95MP0005391_vision/eye_phenotype0.71598835
96MP0000015_abnormal_ear_pigmentation0.71360188
97MP0003195_calcinosis0.70566410
98MP0004484_altered_response_of0.69950074
99MP0002064_seizures0.69223886
100MP0005248_abnormal_Harderian_gland0.68144897

Predicted human phenotypes

RankGene SetZ-score
1Atonic seizures (HP:0010819)4.25838736
2Intestinal atresia (HP:0011100)3.21087867
3Homocystinuria (HP:0002156)3.20344530
4Abnormality of homocysteine metabolism (HP:0010919)3.20344530
5Hyperventilation (HP:0002883)3.15877038
6Abnormality of the labia minora (HP:0012880)3.11065420
7Chronic hepatic failure (HP:0100626)3.03659538
8Oligodactyly (hands) (HP:0001180)3.02764443
9Thyroid-stimulating hormone excess (HP:0002925)2.89440128
10Drooling (HP:0002307)2.89343486
11Methylmalonic acidemia (HP:0002912)2.79805369
12Volvulus (HP:0002580)2.79569170
13Abnormality of alanine metabolism (HP:0010916)2.70142088
14Hyperalaninemia (HP:0003348)2.70142088
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70142088
16Hip dysplasia (HP:0001385)2.66233871
17Focal seizures (HP:0007359)2.65473085
18Excessive salivation (HP:0003781)2.65105421
19Urinary urgency (HP:0000012)2.64737460
20Absent rod-and cone-mediated responses on ERG (HP:0007688)2.58474866
21Conjugated hyperbilirubinemia (HP:0002908)2.57719872
22Absence seizures (HP:0002121)2.56352318
23Degeneration of the lateral corticospinal tracts (HP:0002314)2.52819012
24Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.52819012
25Dialeptic seizures (HP:0011146)2.51197095
26Abnormality of the renal medulla (HP:0100957)2.50522021
27Abnormality of midbrain morphology (HP:0002418)2.48416176
28Molar tooth sign on MRI (HP:0002419)2.48416176
29Type 2 muscle fiber atrophy (HP:0003554)2.47652600
30Abnormal rod and cone electroretinograms (HP:0008323)2.46139395
31Abnormal lung lobation (HP:0002101)2.43777833
32Broad-based gait (HP:0002136)2.42363901
33Polyphagia (HP:0002591)2.41609183
34Abnormality of the renal cortex (HP:0011035)2.38814662
35Nephronophthisis (HP:0000090)2.37607142
36Hepatoblastoma (HP:0002884)2.36479040
37Small hand (HP:0200055)2.34309935
38Febrile seizures (HP:0002373)2.32853149
39Insidious onset (HP:0003587)2.24333675
40Termporal pattern (HP:0011008)2.24333675
41Long clavicles (HP:0000890)2.23118164
42Pancreatic fibrosis (HP:0100732)2.18594949
43Urinary bladder sphincter dysfunction (HP:0002839)2.16890537
44Nephroblastoma (Wilms tumor) (HP:0002667)2.15338466
45Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.13420109
46Abnormality of macular pigmentation (HP:0008002)2.12245539
47Renal cortical cysts (HP:0000803)2.11106068
48Embryonal renal neoplasm (HP:0011794)2.10835371
49Lissencephaly (HP:0001339)2.05306170
50Abnormality of the corticospinal tract (HP:0002492)2.03621839
51Nephrogenic diabetes insipidus (HP:0009806)2.03424680
52Genetic anticipation (HP:0003743)2.03410675
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.03050473
54Short chin (HP:0000331)2.01808245
55Protruding tongue (HP:0010808)2.01393354
56Impaired vibration sensation in the lower limbs (HP:0002166)2.01355262
5711 pairs of ribs (HP:0000878)1.98569877
58Posterior subcapsular cataract (HP:0007787)1.98412398
59Absent speech (HP:0001344)1.98073444
60Abnormality of methionine metabolism (HP:0010901)1.94055451
61Papillary thyroid carcinoma (HP:0002895)1.93191844
62Abnormality of the vitamin B12 metabolism (HP:0004341)1.93179619
63Epileptic encephalopathy (HP:0200134)1.92426219
64Neoplasm of the colon (HP:0100273)1.91366767
65Upper limb muscle weakness (HP:0003484)1.90250309
66Pancreatic cysts (HP:0001737)1.89018801
67Generalized tonic-clonic seizures (HP:0002069)1.88254585
68Neoplasm of the peripheral nervous system (HP:0100007)1.87209726
69Abnormality of the phalanges of the 5th finger (HP:0004213)1.86831779
70Hypoplastic pelvis (HP:0008839)1.86558354
71Medial flaring of the eyebrow (HP:0010747)1.86380954
72Colon cancer (HP:0003003)1.86014721
73Inability to walk (HP:0002540)1.84849903
74Labial hypoplasia (HP:0000066)1.84815278
75Neoplasm of the adrenal cortex (HP:0100641)1.83385293
76Methylmalonic aciduria (HP:0012120)1.83157320
77Abnormality of vitamin B metabolism (HP:0004340)1.82258114
78Muscle fiber atrophy (HP:0100295)1.82146634
79Neoplasm of the small intestine (HP:0100833)1.81642255
80Patellar aplasia (HP:0006443)1.80665076
81Oligodactyly (HP:0012165)1.80445796
82Narrow forehead (HP:0000341)1.79209327
83Hypoplastic female external genitalia (HP:0012815)1.79148444
84Stenosis of the external auditory canal (HP:0000402)1.78511238
85Gaze-evoked nystagmus (HP:0000640)1.78271504
86Agitation (HP:0000713)1.77021225
87Constricted visual fields (HP:0001133)1.75753841
88Pachygyria (HP:0001302)1.74889445
89Bony spicule pigmentary retinopathy (HP:0007737)1.74512249
90Status epilepticus (HP:0002133)1.72509911
91Symphalangism affecting the phalanges of the hand (HP:0009773)1.71243884
92Inappropriate behavior (HP:0000719)1.69618035
93Highly arched eyebrow (HP:0002553)1.68428610
94Intellectual disability, moderate (HP:0002342)1.66578040
95Median cleft lip (HP:0000161)1.66378601
96Attenuation of retinal blood vessels (HP:0007843)1.66314674
97Abnormality of serum amino acid levels (HP:0003112)1.64277176
98Birth length less than 3rd percentile (HP:0003561)1.64083861
99Oculomotor apraxia (HP:0000657)1.63606925
100Astigmatism (HP:0000483)1.63370825

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.53426510
2NUAK13.96143205
3CASK3.91252876
4WNK33.36074444
5MAP3K43.30421865
6FRK3.28391006
7TRIM282.60783709
8PLK42.32498492
9MAP2K72.30325358
10CAMKK22.28537562
11INSRR2.17917411
12CAMK1D2.04221570
13BCR2.03313818
14ADRBK21.97906587
15CAMK1G1.87844033
16BRD41.85581347
17TNIK1.83464970
18PIK3CG1.75970210
19MARK11.74043039
20PINK11.59400753
21NEK11.56436937
22ACVR1B1.56179747
23AKT31.52175807
24CSNK1G11.43843428
25STK161.43486546
26BUB11.42710217
27BMPR1B1.41698213
28CSNK1G21.29988920
29BRSK21.24986585
30CDC71.24048769
31MAP4K21.23635204
32MKNK21.20249368
33BCKDK1.15088024
34SIK31.09884781
35CSNK1G31.09040501
36CCNB11.07775168
37MST41.07421523
38MAP2K41.06158372
39PLK21.02980822
40MAP3K61.00797783
41EIF2AK10.96663948
42ERBB30.96523586
43PDK20.95369498
44STK30.91984495
45CDK30.90041849
46ZAK0.86409693
47CSNK1A1L0.86269352
48SRPK10.83928858
49MKNK10.83397598
50BRAF0.77824896
51DYRK30.75196451
52SGK20.74107785
53EPHA30.71503630
54DAPK20.68666356
55SGK4940.65043027
56SGK2230.65043027
57PAK30.62871843
58GRK10.61846983
59MAPK130.60275519
60CAMKK10.60143342
61PBK0.58893179
62PIK3CA0.57651315
63NTRK20.55662462
64PLK30.55279427
65FLT30.54184975
66PRKCG0.52791199
67MINK10.51920675
68DYRK20.51409038
69CDK190.50167154
70ATM0.47798523
71FGFR10.46020567
72MAP3K50.45525296
73PRKCE0.45424677
74PLK10.44334939
75CAMK40.41849127
76CAMK2A0.40769188
77CSNK1E0.40568530
78TEC0.40073352
79ATR0.37105749
80NTRK30.36292173
81OBSCN0.35420526
82OXSR10.34572978
83PRKG10.33270668
84YES10.32978959
85TTK0.32475918
86CAMK10.31777823
87RPS6KB10.31384852
88CHEK20.30563895
89CHEK10.29142801
90PNCK0.26860719
91PRKACB0.26853964
92TSSK60.24952746
93ADRBK10.24282189
94MAPK90.23998741
95SGK30.23585877
96TGFBR10.21757057
97WNK10.21620898
98RPS6KA60.20926840
99DYRK1A0.20722683
100PAK60.20487676

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.83465727
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.71756529
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.51582856
4Nicotine addiction_Homo sapiens_hsa050332.95239500
5One carbon pool by folate_Homo sapiens_hsa006702.74917090
6Homologous recombination_Homo sapiens_hsa034402.50717604
7Steroid biosynthesis_Homo sapiens_hsa001002.50234673
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25637697
9Basal transcription factors_Homo sapiens_hsa030222.16529649
10Protein export_Homo sapiens_hsa030602.13037242
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98962412
12Butanoate metabolism_Homo sapiens_hsa006501.97606401
13Propanoate metabolism_Homo sapiens_hsa006401.92919722
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90721044
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.85317772
16Non-homologous end-joining_Homo sapiens_hsa034501.82839130
17Fanconi anemia pathway_Homo sapiens_hsa034601.71914841
18Ether lipid metabolism_Homo sapiens_hsa005651.59752798
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52146271
20* Taste transduction_Homo sapiens_hsa047421.40321801
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35855025
22RNA transport_Homo sapiens_hsa030131.33561831
23Linoleic acid metabolism_Homo sapiens_hsa005911.33351603
24RNA degradation_Homo sapiens_hsa030181.29598292
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23865259
26Long-term depression_Homo sapiens_hsa047301.23815565
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23536232
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22595231
29GABAergic synapse_Homo sapiens_hsa047271.22189320
30Regulation of autophagy_Homo sapiens_hsa041401.20497012
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16845120
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15483082
33Morphine addiction_Homo sapiens_hsa050321.12243391
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.10851464
35Cell cycle_Homo sapiens_hsa041101.09801914
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.09632063
37Phototransduction_Homo sapiens_hsa047441.09375671
38Fatty acid biosynthesis_Homo sapiens_hsa000611.06968840
39Nucleotide excision repair_Homo sapiens_hsa034201.06029807
40Peroxisome_Homo sapiens_hsa041461.02245029
41Proteasome_Homo sapiens_hsa030500.95918468
42Caffeine metabolism_Homo sapiens_hsa002320.88557285
43Mismatch repair_Homo sapiens_hsa034300.85105913
44Base excision repair_Homo sapiens_hsa034100.81862619
45Colorectal cancer_Homo sapiens_hsa052100.80787677
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79926219
47Pyruvate metabolism_Homo sapiens_hsa006200.76475214
48Glutamatergic synapse_Homo sapiens_hsa047240.76226612
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75436558
50Melanoma_Homo sapiens_hsa052180.73869685
51Dopaminergic synapse_Homo sapiens_hsa047280.73770933
52RNA polymerase_Homo sapiens_hsa030200.73412699
53Serotonergic synapse_Homo sapiens_hsa047260.71198777
54Inositol phosphate metabolism_Homo sapiens_hsa005620.70992301
55Purine metabolism_Homo sapiens_hsa002300.70513813
56FoxO signaling pathway_Homo sapiens_hsa040680.69905996
57Oocyte meiosis_Homo sapiens_hsa041140.69202342
58Amphetamine addiction_Homo sapiens_hsa050310.63215914
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59183970
60Hedgehog signaling pathway_Homo sapiens_hsa043400.58246478
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.58238947
62Selenocompound metabolism_Homo sapiens_hsa004500.57474913
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56778239
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.56768958
65Nitrogen metabolism_Homo sapiens_hsa009100.56364072
66Cardiac muscle contraction_Homo sapiens_hsa042600.54239150
67Oxytocin signaling pathway_Homo sapiens_hsa049210.54119098
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53891296
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53020139
70Circadian rhythm_Homo sapiens_hsa047100.52285987
71Parkinsons disease_Homo sapiens_hsa050120.51993106
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50228441
73mRNA surveillance pathway_Homo sapiens_hsa030150.50131123
74Circadian entrainment_Homo sapiens_hsa047130.50072702
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48022647
76Olfactory transduction_Homo sapiens_hsa047400.47467993
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47433870
78Long-term potentiation_Homo sapiens_hsa047200.45430919
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44203957
80Synaptic vesicle cycle_Homo sapiens_hsa047210.43285565
81ErbB signaling pathway_Homo sapiens_hsa040120.43139556
82Pyrimidine metabolism_Homo sapiens_hsa002400.42439589
83Alcoholism_Homo sapiens_hsa050340.41552538
84mTOR signaling pathway_Homo sapiens_hsa041500.40743714
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39649268
86Choline metabolism in cancer_Homo sapiens_hsa052310.38134186
87Ras signaling pathway_Homo sapiens_hsa040140.37135683
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.35432375
89cAMP signaling pathway_Homo sapiens_hsa040240.34756848
90Metabolic pathways_Homo sapiens_hsa011000.34662932
91Axon guidance_Homo sapiens_hsa043600.33856448
92Huntingtons disease_Homo sapiens_hsa050160.33497769
93Oxidative phosphorylation_Homo sapiens_hsa001900.32917051
94Cholinergic synapse_Homo sapiens_hsa047250.32777854
95Type II diabetes mellitus_Homo sapiens_hsa049300.32764127
96TGF-beta signaling pathway_Homo sapiens_hsa043500.31854187
97Spliceosome_Homo sapiens_hsa030400.31106664
98Platelet activation_Homo sapiens_hsa046110.31079826
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.30847125
100Chemical carcinogenesis_Homo sapiens_hsa052040.30686157

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