ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	retinal cone cell development (GO:0046549)	5.76480396
2	negative regulation of DNA recombination (GO:0045910)	5.42104720
3	DNA double-strand break processing (GO:0000729)	4.71158325
4	pyrimidine nucleobase catabolic process (GO:0006208)	4.41472609
5	neurofilament cytoskeleton organization (GO:0060052)	4.30783564
6	protein localization to synapse (GO:0035418)	4.05975233
7	fatty acid elongation (GO:0030497)	3.87998998
8	negative regulation of axon guidance (GO:1902668)	3.73248569
9	acrosome reaction (GO:0007340)	3.57202251
10	retinal ganglion cell axon guidance (GO:0031290)	3.56256369
11	detection of light stimulus involved in visual perception (GO:0050908)	3.53927685
12	detection of light stimulus involved in sensory perception (GO:0050962)	3.53927685
13	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.51088471
14	nucleobase catabolic process (GO:0046113)	3.49899434
15	gamma-aminobutyric acid transport (GO:0015812)	3.45891262
16	response to pheromone (GO:0019236)	3.42789331
17	resolution of meiotic recombination intermediates (GO:0000712)	3.42104044
18	glycosphingolipid biosynthetic process (GO:0006688)	3.31995139
19	neuron cell-cell adhesion (GO:0007158)	3.20560156
20	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.19926667
21	presynaptic membrane assembly (GO:0097105)	3.18613334
22	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.17134436
23	neuronal action potential propagation (GO:0019227)	3.16668468
24	ribonucleoprotein complex disassembly (GO:0032988)	3.14032489
25	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.10266705
26	regulation of mitotic spindle checkpoint (GO:1903504)	3.10266705
27	serotonin metabolic process (GO:0042428)	3.06714756
28	auditory behavior (GO:0031223)	3.03610308
29	synaptic vesicle endocytosis (GO:0048488)	3.01380820
30	metaphase plate congression (GO:0051310)	3.01377722
31	anterograde axon cargo transport (GO:0008089)	2.98478958
32	mechanosensory behavior (GO:0007638)	2.95921945
33	histone H2A acetylation (GO:0043968)	2.92638503
34	photoreceptor cell development (GO:0042461)	2.87794435
35	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.86899333
36	eye photoreceptor cell development (GO:0042462)	2.85550964
37	postsynaptic membrane organization (GO:0001941)	2.84366916
38	respiratory chain complex IV assembly (GO:0008535)	2.83764027
39	replication fork processing (GO:0031297)	2.83634411
40	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.83522833
41	axon extension involved in axon guidance (GO:0048846)	2.83522833
42	organelle disassembly (GO:1903008)	2.80890636
43	intraciliary transport (GO:0042073)	2.80843925
44	protein-cofactor linkage (GO:0018065)	2.80566637
45	prostate gland growth (GO:0060736)	2.77229948
46	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.76518126
47	limb bud formation (GO:0060174)	2.75997189
48	primary amino compound metabolic process (GO:1901160)	2.74202025
49	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.72621774
50	microtubule depolymerization (GO:0007019)	2.72615378
51	presynaptic membrane organization (GO:0097090)	2.72551267
52	regulation of chemokine-mediated signaling pathway (GO:0070099)	2.72026468
53	anterograde synaptic vesicle transport (GO:0048490)	2.72014979
54	axonal fasciculation (GO:0007413)	2.70073519
55	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.69583698
56	synaptic vesicle transport (GO:0048489)	2.68742457
57	establishment of synaptic vesicle localization (GO:0097480)	2.68742457
58	regulation of centriole replication (GO:0046599)	2.67395110
59	DNA integration (GO:0015074)	2.62174380
60	regulation of telomere maintenance (GO:0032204)	2.61400671
61	negative regulation of Rho protein signal transduction (GO:0035024)	2.61071943
62	microtubule anchoring (GO:0034453)	2.61058192
63	peroxisome fission (GO:0016559)	2.60152999
64	negative regulation of microtubule depolymerization (GO:0007026)	2.58697030
65	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.57986246
66	protein K6-linked ubiquitination (GO:0085020)	2.57319591
67	sequestering of actin monomers (GO:0042989)	2.56452470
68	microtubule polymerization or depolymerization (GO:0031109)	2.55990728
69	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.55948636
70	positive regulation of mRNA processing (GO:0050685)	2.55871792
71	regulation of voltage-gated calcium channel activity (GO:1901385)	2.55294195
72	neural tube formation (GO:0001841)	2.54832691
73	protein prenylation (GO:0018342)	2.54715749
74	prenylation (GO:0097354)	2.54715749
75	synapse assembly (GO:0007416)	2.53428841
76	regulation of spindle organization (GO:0090224)	2.52487800
77	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.51987377
78	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.51987377
79	establishment of vesicle localization (GO:0051650)	2.51927482
80	DNA strand renaturation (GO:0000733)	2.49912985
81	hippocampus development (GO:0021766)	2.49581408
82	protein localization to chromosome (GO:0034502)	2.49515875
83	somite development (GO:0061053)	2.49020839
84	cytoskeleton-dependent intracellular transport (GO:0030705)	2.47948196
85	spindle checkpoint (GO:0031577)	2.47901239
86	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.45624159
87	regulation of axon guidance (GO:1902667)	2.45490807
88	neuron-neuron synaptic transmission (GO:0007270)	2.44166274
89	spermatid nucleus differentiation (GO:0007289)	2.43734402
90	photoreceptor cell maintenance (GO:0045494)	2.42972137
91	regulation of relaxation of muscle (GO:1901077)	2.42618240
92	peptidyl-cysteine modification (GO:0018198)	2.42613845
93	protein localization to kinetochore (GO:0034501)	2.42322283
94	centriole replication (GO:0007099)	2.42236085
95	histone mRNA catabolic process (GO:0071044)	2.42002684
96	regulation of microtubule depolymerization (GO:0031114)	2.40529798
97	nonmotile primary cilium assembly (GO:0035058)	2.39852260
98	negative regulation of telomere maintenance (GO:0032205)	2.39705835
99	synaptic vesicle exocytosis (GO:0016079)	2.38939951
100	postreplication repair (GO:0006301)	2.38319151

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.64121908
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.44110120
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.14406758
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.97360186
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.88056965
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.81979746
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.62890646
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.56310027
9	FUS_26573619_Chip-Seq_HEK293_Human	2.40235746
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.38669817
11	VDR_22108803_ChIP-Seq_LS180_Human	2.26063927
12	P300_19829295_ChIP-Seq_ESCs_Human	2.19494873
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.09945072
14	EZH2_22144423_ChIP-Seq_EOC_Human	2.05389739
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04961862
16	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.04906132
17	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.04593740
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.04553597
19	EWS_26573619_Chip-Seq_HEK293_Human	2.02651182
20	SMAD4_21799915_ChIP-Seq_A2780_Human	1.92120838
21	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.90871353
22	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.89690855
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.86929036
24	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.82263382
25	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.81019759
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.79900411
27	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.79492145
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73141203
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.72374972
30	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.68484023
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.65114244
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.64975223
33	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.62514799
34	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.61159705
35	STAT3_23295773_ChIP-Seq_U87_Human	1.60953610
36	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.60811440
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.57050859
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55679406
39	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.52405325
40	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.52246722
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52188509
42	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.50193381
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.49718119
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.49201507
45	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.48645085
46	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.45183047
47	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.44262771
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.43237102
49	TCF4_23295773_ChIP-Seq_U87_Human	1.42030006
50	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41368434
51	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.40313542
52	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.39463566
53	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39328814
54	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.37291724
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37016417
56	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.36727412
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36361120
58	JUN_21703547_ChIP-Seq_K562_Human	1.36093057
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.33669079
60	AR_25329375_ChIP-Seq_VCAP_Human	1.33448226
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31791516
62	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.31440479
63	BCAT_22108803_ChIP-Seq_LS180_Human	1.30647048
64	CBP_20019798_ChIP-Seq_JUKART_Human	1.29418760
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29418760
66	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.26471692
67	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.25003816
68	AR_21572438_ChIP-Seq_LNCaP_Human	1.23738860
69	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.23447522
70	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.22341824
71	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.19812844
72	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.19147818
73	P53_22387025_ChIP-Seq_ESCs_Mouse	1.19018221
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18882348
75	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.18060913
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17447201
77	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.17319184
78	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.16661631
79	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.15701014
80	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15577094
81	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13833170
82	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.12029669
83	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.10760005
84	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.09720022
85	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.08862627
86	SOX9_26525672_Chip-Seq_HEART_Mouse	1.08424339
87	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.08095689
88	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06273860
89	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.06149766
90	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.06149766
91	REST_21632747_ChIP-Seq_MESCs_Mouse	1.05739607
92	TCF4_22108803_ChIP-Seq_LS180_Human	1.05156009
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03929177
94	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.02932542
95	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01535885
96	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01437804
97	P300_18555785_Chip-Seq_ESCs_Mouse	1.01185072
98	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.00897839
99	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.99772119
100	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.97661422

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.92963339
2	MP0003880_abnormal_central_pattern	3.21550101
3	MP0001529_abnormal_vocalization	2.62811722
4	MP0001984_abnormal_olfaction	2.62617700
5	MP0000569_abnormal_digit_pigmentation	2.55799607
6	MP0009046_muscle_twitch	2.52918622
7	MP0001188_hyperpigmentation	2.46075376
8	MP0005551_abnormal_eye_electrophysiolog	2.41898148
9	MP0006276_abnormal_autonomic_nervous	2.10078722
10	MP0002234_abnormal_pharynx_morphology	2.09412831
11	MP0000383_abnormal_hair_follicle	2.07918496
12	MP0001486_abnormal_startle_reflex	2.04613226
13	MP0000778_abnormal_nervous_system	2.01448252
14	MP0002751_abnormal_autonomic_nervous	1.92402890
15	MP0000751_myopathy	1.90078894
16	MP0005253_abnormal_eye_physiology	1.89222082
17	MP0005423_abnormal_somatic_nervous	1.85988358
18	MP0002272_abnormal_nervous_system	1.82108978
19	MP0000427_abnormal_hair_cycle	1.80249968
20	MP0004270_analgesia	1.76309368
21	MP0009745_abnormal_behavioral_response	1.70497532
22	MP0008877_abnormal_DNA_methylation	1.69422501
23	MP0003121_genomic_imprinting	1.57067660
24	MP0006072_abnormal_retinal_apoptosis	1.56338168
25	MP0003787_abnormal_imprinting	1.56099942
26	MP0005248_abnormal_Harderian_gland	1.49607692
27	MP0008058_abnormal_DNA_repair	1.49303045
28	MP0002064_seizures	1.48340080
29	MP0003635_abnormal_synaptic_transmissio	1.46395455
30	MP0004145_abnormal_muscle_electrophysio	1.42218393
31	MP0005171_absent_coat_pigmentation	1.41648917
32	MP0002067_abnormal_sensory_capabilities	1.41423844
33	MP0010094_abnormal_chromosome_stability	1.38928281
34	MP0005645_abnormal_hypothalamus_physiol	1.38838902
35	MP0003122_maternal_imprinting	1.38808592
36	MP0002572_abnormal_emotion/affect_behav	1.38741439
37	MP0005386_behavior/neurological_phenoty	1.34497483
38	MP0004924_abnormal_behavior	1.34497483
39	MP0008007_abnormal_cellular_replicative	1.34319684
40	MP0000647_abnormal_sebaceous_gland	1.28996461
41	MP0003890_abnormal_embryonic-extraembry	1.28726247
42	MP0000372_irregular_coat_pigmentation	1.28679682
43	MP0000749_muscle_degeneration	1.27019324
44	MP0002734_abnormal_mechanical_nocicepti	1.26855890
45	MP0004215_abnormal_myocardial_fiber	1.25886469
46	MP0008057_abnormal_DNA_replication	1.24045022
47	MP0002063_abnormal_learning/memory/cond	1.23033767
48	MP0001501_abnormal_sleep_pattern	1.22915840
49	MP0004142_abnormal_muscle_tone	1.22112102
50	MP0004859_abnormal_synaptic_plasticity	1.20734753
51	MP0002184_abnormal_innervation	1.19398960
52	MP0010678_abnormal_skin_adnexa	1.18160894
53	MP0002282_abnormal_trachea_morphology	1.17658224
54	MP0003283_abnormal_digestive_organ	1.16100812
55	MP0002557_abnormal_social/conspecific_i	1.15873279
56	MP0004811_abnormal_neuron_physiology	1.15387094
57	MP0002882_abnormal_neuron_morphology	1.14374915
58	MP0001293_anophthalmia	1.13870974
59	MP0000955_abnormal_spinal_cord	1.13332788
60	MP0005646_abnormal_pituitary_gland	1.11928424
61	MP0006035_abnormal_mitochondrial_morpho	1.11473140
62	MP0003937_abnormal_limbs/digits/tail_de	1.11022053
63	MP0000566_synostosis	1.10709796
64	MP0002752_abnormal_somatic_nervous	1.09937767
65	MP0003950_abnormal_plasma_membrane	1.09509848
66	MP0006292_abnormal_olfactory_placode	1.08182513
67	MP0002090_abnormal_vision	1.07388058
68	MP0002332_abnormal_exercise_endurance	1.06356043
69	MP0002233_abnormal_nose_morphology	1.05812027
70	MP0002638_abnormal_pupillary_reflex	1.05425915
71	MP0002229_neurodegeneration	1.05396780
72	MP0005187_abnormal_penis_morphology	1.05293281
73	MP0003718_maternal_effect	1.05203935
74	MP0005394_taste/olfaction_phenotype	1.03706164
75	MP0005499_abnormal_olfactory_system	1.03706164
76	MP0005195_abnormal_posterior_eye	1.00297519
77	MP0000358_abnormal_cell_content/	0.99856848
78	MP0000631_abnormal_neuroendocrine_gland	0.98141236
79	MP0005391_vision/eye_phenotype	0.97802572
80	MP0001299_abnormal_eye_distance/	0.95679690
81	MP0001929_abnormal_gametogenesis	0.95144117
82	MP0002938_white_spotting	0.89556867
83	MP0008569_lethality_at_weaning	0.89535285
84	MP0002822_catalepsy	0.89307184
85	MP0003221_abnormal_cardiomyocyte_apopto	0.88938643
86	MP0001986_abnormal_taste_sensitivity	0.88091650
87	MP0003755_abnormal_palate_morphology	0.87331878
88	MP0001324_abnormal_eye_pigmentation	0.86764121
89	MP0003698_abnormal_male_reproductive	0.85207105
90	MP0001177_atelectasis	0.83447196
91	MP0002735_abnormal_chemical_nociception	0.83336193
92	MP0003935_abnormal_craniofacial_develop	0.82379003
93	MP0003077_abnormal_cell_cycle	0.78739113
94	MP0002152_abnormal_brain_morphology	0.78276005
95	MP0001968_abnormal_touch/_nociception	0.77637255
96	MP0001286_abnormal_eye_development	0.75699287
97	MP0002066_abnormal_motor_capabilities/c	0.74348651
98	MP0001661_extended_life_span	0.74145343
99	MP0009703_decreased_birth_body	0.72248467
100	MP0003631_nervous_system_phenotype	0.71281592

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ulnar claw (HP:0001178)	4.91832870
2	Hypothermia (HP:0002045)	3.89094953
3	Cortical dysplasia (HP:0002539)	3.56117525
4	Limb dystonia (HP:0002451)	3.46732102
5	Medial flaring of the eyebrow (HP:0010747)	3.38639838
6	Volvulus (HP:0002580)	3.30096820
7	Gait imbalance (HP:0002141)	3.18267422
8	Abnormality of the labia minora (HP:0012880)	3.10281900
9	Congenital primary aphakia (HP:0007707)	3.05162293
10	Abnormal hair whorl (HP:0010721)	3.04009027
11	Abnormality of the astrocytes (HP:0100707)	2.93428358
12	Astrocytoma (HP:0009592)	2.93428358
13	Aqueductal stenosis (HP:0002410)	2.86898133
14	Genital tract atresia (HP:0001827)	2.86210798
15	Pheochromocytoma (HP:0002666)	2.85216173
16	Ependymoma (HP:0002888)	2.78430562
17	Focal motor seizures (HP:0011153)	2.73552308
18	Atonic seizures (HP:0010819)	2.72328419
19	Vaginal atresia (HP:0000148)	2.61548850
20	Nephrogenic diabetes insipidus (HP:0009806)	2.60344431
21	Optic nerve hypoplasia (HP:0000609)	2.53541481
22	Rhabdomyosarcoma (HP:0002859)	2.47560807
23	Tubulointerstitial nephritis (HP:0001970)	2.45123452
24	Type II lissencephaly (HP:0007260)	2.43085771
25	Intestinal atresia (HP:0011100)	2.41453144
26	Abnormality of the anterior horn cell (HP:0006802)	2.38811103
27	Degeneration of anterior horn cells (HP:0002398)	2.38811103
28	Drooling (HP:0002307)	2.36091249
29	Pancreatic cysts (HP:0001737)	2.35037673
30	Progressive inability to walk (HP:0002505)	2.34298782
31	Febrile seizures (HP:0002373)	2.31691724
32	Renal cortical cysts (HP:0000803)	2.29213736
33	Oligodactyly (hands) (HP:0001180)	2.26976797
34	Colon cancer (HP:0003003)	2.24979167
35	Glioma (HP:0009733)	2.24972603
36	Pancreatic fibrosis (HP:0100732)	2.23754104
37	Poor coordination (HP:0002370)	2.20903051
38	Agnosia (HP:0010524)	2.20683552
39	Specific learning disability (HP:0001328)	2.20482923
40	Postaxial hand polydactyly (HP:0001162)	2.18310607
41	Gaze-evoked nystagmus (HP:0000640)	2.16229526
42	Neoplasm of the small intestine (HP:0100833)	2.16227349
43	Labial hypoplasia (HP:0000066)	2.14456557
44	Papillary thyroid carcinoma (HP:0002895)	2.14426828
45	Focal seizures (HP:0007359)	2.11462699
46	Neuroendocrine neoplasm (HP:0100634)	2.11216396
47	Decreased muscle mass (HP:0003199)	2.11111279
48	Excessive salivation (HP:0003781)	2.08916170
49	Hypoplastic female external genitalia (HP:0012815)	2.07746046
50	Biliary tract neoplasm (HP:0100574)	2.07056826
51	Lissencephaly (HP:0001339)	2.04551123
52	Urinary urgency (HP:0000012)	2.03868635
53	Scanning speech (HP:0002168)	2.03844455
54	Bifid tongue (HP:0010297)	2.03782811
55	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.01853815
56	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.01853815
57	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.00190249
58	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.99479447
59	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.98985023
60	Tubulointerstitial abnormality (HP:0001969)	1.98370951
61	Increased hepatocellular lipid droplets (HP:0006565)	1.98307777
62	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.98004135
63	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.96616360
64	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.96616360
65	Micropenis (HP:0000054)	1.96563523
66	Medulloblastoma (HP:0002885)	1.95945146
67	Steppage gait (HP:0003376)	1.94887611
68	Spastic tetraplegia (HP:0002510)	1.94855035
69	Retinal dysplasia (HP:0007973)	1.94039839
70	Decreased testicular size (HP:0008734)	1.94029406
71	Failure to thrive in infancy (HP:0001531)	1.92850520
72	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.89452294
73	Birth length less than 3rd percentile (HP:0003561)	1.89175031
74	Astigmatism (HP:0000483)	1.88995769
75	Abnormality of midbrain morphology (HP:0002418)	1.86271370
76	Molar tooth sign on MRI (HP:0002419)	1.86271370
77	Chronic hepatic failure (HP:0100626)	1.85878967
78	Amblyopia (HP:0000646)	1.85438519
79	Growth hormone deficiency (HP:0000824)	1.84710076
80	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.84442296
81	Hypoplasia of the brainstem (HP:0002365)	1.84442296
82	Abnormality of the renal cortex (HP:0011035)	1.83910927
83	Posterior subcapsular cataract (HP:0007787)	1.83047359
84	Abnormality of the corticospinal tract (HP:0002492)	1.83011053
85	Oligodactyly (HP:0012165)	1.82951940
86	Dysdiadochokinesis (HP:0002075)	1.82763024
87	Cerebellar dysplasia (HP:0007033)	1.82376999
88	Nephroblastoma (Wilms tumor) (HP:0002667)	1.82325307
89	Abnormality of chromosome stability (HP:0003220)	1.82067127
90	Anophthalmia (HP:0000528)	1.81630370
91	Postaxial foot polydactyly (HP:0001830)	1.81523746
92	Embryonal renal neoplasm (HP:0011794)	1.80626330
93	Abnormal gallbladder physiology (HP:0012438)	1.79768741
94	Cholecystitis (HP:0001082)	1.79768741
95	Abnormality of the musculature of the pelvis (HP:0001469)	1.79594591
96	Abnormality of the hip-girdle musculature (HP:0001445)	1.79594591
97	Dialeptic seizures (HP:0011146)	1.78642282
98	Neoplasm of the colon (HP:0100273)	1.76353500
99	Inability to walk (HP:0002540)	1.74891455
100	Small intestinal stenosis (HP:0012848)	1.72403483

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.87683545
2	PDK2	3.55621987
3	WNK3	3.40318305
4	BMPR1B	2.93362132
5	MAP3K4	2.74431548
6	EIF2AK3	2.69486145
7	BUB1	2.59571506
8	NEK1	2.52329585
9	BCR	2.46344754
10	FRK	2.43906591
11	MARK1	2.40976544
12	ERBB3	2.28095625
13	TRIM28	1.96763593
14	MKNK2	1.93664634
15	STK39	1.66374933
16	MAPK13	1.47067566
17	OXSR1	1.44118581
18	TSSK6	1.41282641
19	SRPK1	1.40803420
20	GRK7	1.38491256
21	TNIK	1.35543707
22	PLK3	1.33521901
23	CSNK1G2	1.31982969
24	CASK	1.21042798
25	MINK1	1.21009404
26	BRSK2	1.20867958
27	MAP3K12	1.18839532
28	PLK2	1.16744150
29	CSNK1A1L	1.15849043
30	PAK3	1.14263694
31	CSNK1G1	1.13423152
32	CSNK1G3	1.12530384
33	CDK19	1.11731002
34	OBSCN	1.09129477
35	ADRBK2	1.08692586
36	PLK4	1.07280318
37	MKNK1	1.05956597
38	MAP2K7	1.04345774
39	BRSK1	1.03622578
40	FGFR2	1.00731105
41	BRD4	1.00484481
42	CDC7	1.00340088
43	PINK1	0.98780192
44	NEK6	0.93733154
45	DYRK3	0.91648570
46	DYRK1A	0.91511653
47	EIF2AK1	0.91161833
48	FER	0.90520847
49	ACVR1B	0.90518981
50	AKT3	0.88246848
51	STK38L	0.87480579
52	NUAK1	0.86515712
53	TGFBR1	0.84448534
54	PRKCE	0.83965876
55	RPS6KA4	0.80730435
56	NTRK2	0.79912854
57	CAMKK2	0.75329793
58	CAMK2A	0.75301815
59	TTK	0.75197443
60	PIK3CA	0.70645479
61	PLK1	0.70410630
62	MAP2K4	0.70180286
63	EPHA4	0.68467747
64	CDK8	0.63541860
65	SIK3	0.62149405
66	KSR1	0.59829291
67	MAP3K5	0.58136621
68	NTRK3	0.58096893
69	VRK1	0.57216626
70	CDK18	0.52978094
71	ATR	0.52438100
72	DYRK2	0.51475577
73	EIF2AK2	0.50989540
74	PRKCG	0.49381201
75	CDK14	0.48886551
76	STK16	0.48413096
77	NEK2	0.46987459
78	CDK5	0.46643483
79	GRK1	0.44375487
80	ATM	0.42977812
81	CDK15	0.41760406
82	PRKACB	0.41370060
83	ZAK	0.41303478
84	PAK6	0.40339828
85	FGFR1	0.37696404
86	SGK2	0.37689061
87	WEE1	0.34634816
88	UHMK1	0.33414147
89	PIK3CG	0.33115014
90	MELK	0.32998390
91	CDK11A	0.32376079
92	MUSK	0.32046965
93	CSNK1D	0.30684232
94	PRKCZ	0.30634184
95	RPS6KA5	0.29112153
96	SIK2	0.27341052
97	WNK4	0.26845090
98	CSNK1A1	0.26324508
99	AURKB	0.25942000
100	PKN1	0.25740884

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.44567881
2	Protein export_Homo sapiens_hsa03060	3.04681007
3	Nicotine addiction_Homo sapiens_hsa05033	3.00318722
4	Taste transduction_Homo sapiens_hsa04742	2.43618395
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.21503009
6	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.20819807
7	GABAergic synapse_Homo sapiens_hsa04727	2.09609204
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.00341008
9	Propanoate metabolism_Homo sapiens_hsa00640	1.89676277
10	Fanconi anemia pathway_Homo sapiens_hsa03460	1.88179873
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.81073520
12	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.79829822
13	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.68102395
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.66470395
15	Basal transcription factors_Homo sapiens_hsa03022	1.64822876
16	Circadian rhythm_Homo sapiens_hsa04710	1.64345267
17	Oocyte meiosis_Homo sapiens_hsa04114	1.50981990
18	Mismatch repair_Homo sapiens_hsa03430	1.49629020
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.47816467
20	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.47557521
21	Morphine addiction_Homo sapiens_hsa05032	1.44293810
22	RNA degradation_Homo sapiens_hsa03018	1.43584493
23	Cocaine addiction_Homo sapiens_hsa05030	1.38236127
24	Steroid biosynthesis_Homo sapiens_hsa00100	1.37308111
25	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.34976686
26	Oxidative phosphorylation_Homo sapiens_hsa00190	1.29332533
27	Regulation of autophagy_Homo sapiens_hsa04140	1.29181538
28	Dopaminergic synapse_Homo sapiens_hsa04728	1.27952942
29	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.25067874
30	Glutamatergic synapse_Homo sapiens_hsa04724	1.20353874
31	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.14923632
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.14522062
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.12336783
34	Amphetamine addiction_Homo sapiens_hsa05031	1.10385062
35	Parkinsons disease_Homo sapiens_hsa05012	1.07649303
36	Circadian entrainment_Homo sapiens_hsa04713	1.06932153
37	Alcoholism_Homo sapiens_hsa05034	1.02286046
38	Olfactory transduction_Homo sapiens_hsa04740	1.01090850
39	Selenocompound metabolism_Homo sapiens_hsa00450	0.99614641
40	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.98386187
41	One carbon pool by folate_Homo sapiens_hsa00670	0.98193369
42	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.98107022
43	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.97738872
44	Fatty acid elongation_Homo sapiens_hsa00062	0.96910502
45	Cardiac muscle contraction_Homo sapiens_hsa04260	0.95559345
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.94054429
47	Cell cycle_Homo sapiens_hsa04110	0.93927826
48	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.92577777
49	Caffeine metabolism_Homo sapiens_hsa00232	0.91836887
50	Butanoate metabolism_Homo sapiens_hsa00650	0.90666829
51	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.89669324
52	Peroxisome_Homo sapiens_hsa04146	0.87606231
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.85744331
54	Axon guidance_Homo sapiens_hsa04360	0.85560638
55	Serotonergic synapse_Homo sapiens_hsa04726	0.85051046
56	Histidine metabolism_Homo sapiens_hsa00340	0.84821349
57	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.84791282
58	RNA polymerase_Homo sapiens_hsa03020	0.81809892
59	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.80360056
60	Pyruvate metabolism_Homo sapiens_hsa00620	0.80035364
61	Gap junction_Homo sapiens_hsa04540	0.79264858
62	Vibrio cholerae infection_Homo sapiens_hsa05110	0.77628340
63	Nitrogen metabolism_Homo sapiens_hsa00910	0.75372684
64	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.74719970
65	Salivary secretion_Homo sapiens_hsa04970	0.71880268
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.71853898
67	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.71838248
68	RNA transport_Homo sapiens_hsa03013	0.68683105
69	Renin-angiotensin system_Homo sapiens_hsa04614	0.67311842
70	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.66322139
71	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.66110562
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64785844
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63420034
74	Carbon metabolism_Homo sapiens_hsa01200	0.63124302
75	Lysine degradation_Homo sapiens_hsa00310	0.60672273
76	Proteasome_Homo sapiens_hsa03050	0.60320720
77	Tryptophan metabolism_Homo sapiens_hsa00380	0.58392457
78	Alzheimers disease_Homo sapiens_hsa05010	0.58243566
79	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.57599150
80	Huntingtons disease_Homo sapiens_hsa05016	0.57409352
81	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.56507915
82	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.55744330
83	Nucleotide excision repair_Homo sapiens_hsa03420	0.54698671
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.53961355
85	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.52626697
86	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51004408
87	Homologous recombination_Homo sapiens_hsa03440	0.50736094
88	p53 signaling pathway_Homo sapiens_hsa04115	0.48808065
89	Purine metabolism_Homo sapiens_hsa00230	0.48257047
90	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.46955339
91	Cholinergic synapse_Homo sapiens_hsa04725	0.46483568
92	Hippo signaling pathway_Homo sapiens_hsa04390	0.46079919
93	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.45759186
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43973028
95	Calcium signaling pathway_Homo sapiens_hsa04020	0.43708249
96	mRNA surveillance pathway_Homo sapiens_hsa03015	0.42888812
97	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.42462268
98	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.40679336
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.39435709
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.37478135

TAS2R15P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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