TAS2R19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1eosinophil chemotaxis (GO:0048245)9.42762169
2negative regulation of T cell receptor signaling pathway (GO:0050860)9.01424168
3regulation of sister chromatid cohesion (GO:0007063)8.76742114
4negative regulation of peptidyl-threonine phosphorylation (GO:0010801)8.76719329
5eosinophil migration (GO:0072677)8.53979833
6regulation of mononuclear cell migration (GO:0071675)8.23647210
7L-fucose catabolic process (GO:0042355)7.59524251
8fucose catabolic process (GO:0019317)7.59524251
9L-fucose metabolic process (GO:0042354)7.59524251
10positive regulation of chromosome segregation (GO:0051984)7.56439568
11branch elongation of an epithelium (GO:0060602)7.43543489
12negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)7.13062016
13negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)7.04694214
14peptidyl-lysine dimethylation (GO:0018027)7.00836370
15vesicle fusion (GO:0006906)6.77529148
16coenzyme A biosynthetic process (GO:0015937)6.54956282
17organ growth (GO:0035265)6.46072995
18macrophage chemotaxis (GO:0048246)6.34081491
19autophagic vacuole fusion (GO:0000046)6.07216442
20acrosome assembly (GO:0001675)5.64378946
21ribosomal small subunit assembly (GO:0000028)5.63779379
22axis elongation (GO:0003401)5.62061404
23establishment of mitotic spindle orientation (GO:0000132)5.39360287
24positive regulation of calcium ion import (GO:0090280)5.34552148
25localization within membrane (GO:0051668)5.25531504
26double-strand break repair via nonhomologous end joining (GO:0006303)5.22977121
27non-recombinational repair (GO:0000726)5.22977121
28regulation of nitric-oxide synthase biosynthetic process (GO:0051769)5.20964601
29regulation of beta-amyloid formation (GO:1902003)5.20346389
30protein import into peroxisome matrix (GO:0016558)5.15188715
31negative regulation of GTP catabolic process (GO:0033125)5.11739891
32negative regulation of GTPase activity (GO:0034260)5.11739891
33oxidative demethylation (GO:0070989)5.08733112
34regulation of T cell receptor signaling pathway (GO:0050856)4.97197074
35organelle membrane fusion (GO:0090174)4.93248855
36histone H3-K9 methylation (GO:0051567)4.78248722
37establishment of mitotic spindle localization (GO:0040001)4.77429785
38monocyte chemotaxis (GO:0002548)4.73463355
39establishment of spindle orientation (GO:0051294)4.72591777
40protein targeting to lysosome (GO:0006622)4.72109265
41establishment of protein localization to vacuole (GO:0072666)4.72109265
42protein targeting to vacuole (GO:0006623)4.72109265
43negative regulation of circadian rhythm (GO:0042754)4.66894113
443-UTR-mediated mRNA stabilization (GO:0070935)4.55472958
45regulation of stem cell maintenance (GO:2000036)4.49805433
46DNA integration (GO:0015074)4.31471428
47ribonucleoside bisphosphate biosynthetic process (GO:0034030)4.26507361
48nucleoside bisphosphate biosynthetic process (GO:0033866)4.26507361
49purine nucleoside bisphosphate biosynthetic process (GO:0034033)4.26507361
50regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.22448611
51seminiferous tubule development (GO:0072520)4.16251855
52positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.14726373
53fucosylation (GO:0036065)4.09751909
54positive chemotaxis (GO:0050918)4.07573710
55organelle fusion (GO:0048284)4.02606646
56peptidyl-lysine trimethylation (GO:0018023)3.98752977
57pantothenate metabolic process (GO:0015939)3.96342703
58fucose metabolic process (GO:0006004)3.94735660
59regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)3.93686041
60negative regulation of dendrite morphogenesis (GO:0050774)3.92998913
61histone H3-K9 modification (GO:0061647)3.90194087
62coenzyme A metabolic process (GO:0015936)3.85027217
63regulation of amyloid precursor protein catabolic process (GO:1902991)3.76764484
64negative regulation of dendrite development (GO:2000171)3.73683014
65protein sumoylation (GO:0016925)3.54210224
66regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.53757954
67membrane budding (GO:0006900)3.49384305
68DNA demethylation (GO:0080111)3.49012437
69negative regulation of purine nucleotide catabolic process (GO:0033122)3.47486889
70establishment of spindle localization (GO:0051293)3.46052360
71telomere maintenance via recombination (GO:0000722)3.43878734
72single-organism membrane fusion (GO:0044801)3.42012759
73protein localization to vacuole (GO:0072665)3.41614279
74protein localization to lysosome (GO:0061462)3.41614279
75regulation of peptidyl-threonine phosphorylation (GO:0010799)3.38897189
76labyrinthine layer development (GO:0060711)3.28538359
77imidazole-containing compound metabolic process (GO:0052803)3.26021040
78negative regulation of nucleotide catabolic process (GO:0030812)3.24561831
79negative regulation of macroautophagy (GO:0016242)3.23805521
80regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.23232262
81regulation of calcium ion import (GO:0090279)3.21238155
82protein localization to peroxisome (GO:0072662)3.20455292
83protein targeting to peroxisome (GO:0006625)3.20455292
84establishment of protein localization to peroxisome (GO:0072663)3.20455292
85sodium-independent organic anion transport (GO:0043252)3.14710628
86negative regulation of nucleoside metabolic process (GO:0045978)3.13792145
87preassembly of GPI anchor in ER membrane (GO:0016254)3.08531868
88regulation of autophagic vacuole assembly (GO:2000785)3.06752688
89regulation of cellular amide metabolic process (GO:0034248)3.02877053
90regulation of T cell apoptotic process (GO:0070232)3.01673489
91regulation of mammary gland epithelial cell proliferation (GO:0033599)3.00762614
92COPII vesicle coating (GO:0048208)2.94512132
93negative regulation of Ras protein signal transduction (GO:0046580)2.93520049
94ER to Golgi vesicle-mediated transport (GO:0006888)2.91670166
95prenylation (GO:0097354)12.1906277
96protein prenylation (GO:0018342)12.1906277
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)11.9382836
98positive regulation of mitotic sister chromatid separation (GO:1901970)11.9382836
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)11.9382836
100negative regulation of Ras GTPase activity (GO:0034261)11.2357530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human9.02412849
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.15774863
3VDR_22108803_ChIP-Seq_LS180_Human5.56235304
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.79897945
5NOTCH1_21737748_ChIP-Seq_TLL_Human3.63756340
6AR_21572438_ChIP-Seq_LNCaP_Human3.49819627
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.35626733
8GBX2_23144817_ChIP-Seq_PC3_Human2.80869983
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.57449893
10TAF15_26573619_Chip-Seq_HEK293_Human2.52819290
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16700374
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.13202126
13RXR_22108803_ChIP-Seq_LS180_Human2.12695510
14FUS_26573619_Chip-Seq_HEK293_Human2.09709108
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.05133831
16TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05133831
17ZNF274_21170338_ChIP-Seq_K562_Hela2.02486007
18IRF1_19129219_ChIP-ChIP_H3396_Human1.96127772
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95994024
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88141610
21BCAT_22108803_ChIP-Seq_LS180_Human1.83756490
22TP53_16413492_ChIP-PET_HCT116_Human1.78752139
23OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66575492
24NR3C1_21868756_ChIP-Seq_MCF10A_Human1.65669296
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65372137
26P300_19829295_ChIP-Seq_ESCs_Human1.63450981
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62884134
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.60887883
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53496450
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49175110
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47521404
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39618674
33P53_22127205_ChIP-Seq_FIBROBLAST_Human1.39206131
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39175227
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36496711
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30808832
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29516731
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29037807
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.26140474
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.26092810
41CBP_20019798_ChIP-Seq_JUKART_Human1.25323119
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25323119
43TBX3_20139965_ChIP-Seq_ESCs_Mouse1.24077499
44TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23224881
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.23170068
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22210042
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19002172
48SMAD4_21799915_ChIP-Seq_A2780_Human1.17321199
49GATA3_26560356_Chip-Seq_TH1_Human1.16873368
50IGF1R_20145208_ChIP-Seq_DFB_Human1.15067654
51PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.14943709
52RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12220502
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10751777
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08736013
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08207498
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04798656
57WDR5_24793694_ChIP-Seq_LNCAP_Human1.03781255
58STAT3_23295773_ChIP-Seq_U87_Human1.03334545
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01474546
60SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98476821
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96636028
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96636028
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96636028
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96485624
65EZH2_27294783_Chip-Seq_NPCs_Mouse0.96294185
66SOX2_21211035_ChIP-Seq_LN229_Gbm0.96118469
67RNF2_27304074_Chip-Seq_NSC_Mouse0.95130803
68KDM2B_26808549_Chip-Seq_REH_Human0.94684040
69ZNF263_19887448_ChIP-Seq_K562_Human0.94312702
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93637823
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93247432
72ER_23166858_ChIP-Seq_MCF-7_Human0.93163160
73EWS_26573619_Chip-Seq_HEK293_Human0.92771183
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92515601
75RUNX_20019798_ChIP-Seq_JUKART_Human0.91321901
76NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91137638
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91137638
78TCF4_22108803_ChIP-Seq_LS180_Human0.90590105
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90559364
80SMAD3_21741376_ChIP-Seq_EPCs_Human0.89844058
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89782008
82AR_25329375_ChIP-Seq_VCAP_Human0.88700820
83TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88183741
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88159667
85PRDM14_20953172_ChIP-Seq_ESCs_Human0.87391792
86GATA2_21666600_ChIP-Seq_HMVEC_Human0.87302824
87CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87114642
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85962737
89E2F1_18555785_Chip-Seq_ESCs_Mouse0.85648016
90STAT3_18555785_Chip-Seq_ESCs_Mouse0.85380913
91TP53_22573176_ChIP-Seq_HFKS_Human0.83986859
92RUNX2_22187159_ChIP-Seq_PCA_Human0.83789632
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83353247
94KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81839760
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.80829004
96CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80638417
97FLI1_21867929_ChIP-Seq_TH2_Mouse0.79713664
98YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79500285
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.79152602
100EZH2_22144423_ChIP-Seq_EOC_Human0.78606991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation8.53973486
2MP0006082_CNS_inflammation4.44410312
3MP0003136_yellow_coat_color3.55068022
4MP0002751_abnormal_autonomic_nervous3.17833368
5MP0001664_abnormal_digestion3.03153320
6MP0000467_abnormal_esophagus_morphology3.00284527
7MP0003115_abnormal_respiratory_system2.70325655
8MP0001663_abnormal_digestive_system2.68318487
9MP0001919_abnormal_reproductive_system2.42948763
10MP0000383_abnormal_hair_follicle2.26618240
11MP0005381_digestive/alimentary_phenotyp2.04212890
12MP0000566_synostosis11.5621999
13MP0003937_abnormal_limbs/digits/tail_de1.80830786
14MP0005389_reproductive_system_phenotype1.78445767
15MP0002876_abnormal_thyroid_physiology1.77059117
16MP0001915_intracranial_hemorrhage1.75095243
17MP0010678_abnormal_skin_adnexa1.72205548
18MP0001286_abnormal_eye_development1.71435464
19MP0005171_absent_coat_pigmentation1.66644104
20MP0001293_anophthalmia1.65905784
21MP0000534_abnormal_ureter_morphology1.55856209
22MP0000428_abnormal_craniofacial_morphol1.41665347
23MP0002822_catalepsy1.41117551
24MP0001984_abnormal_olfaction1.39355001
25MP0001545_abnormal_hematopoietic_system1.27458759
26MP0005397_hematopoietic_system_phenotyp1.27458759
27MP0005076_abnormal_cell_differentiation1.27101713
28MP0000569_abnormal_digit_pigmentation1.15421187
29MP0005166_decreased_susceptibility_to1.13161741
30MP0003453_abnormal_keratinocyte_physiol1.05864480
31MP0002109_abnormal_limb_morphology1.05148890
32MP0005253_abnormal_eye_physiology1.01469347
33MP0005187_abnormal_penis_morphology1.00414408
34MP0003763_abnormal_thymus_physiology0.99945824
35MP0002102_abnormal_ear_morphology0.98306225
36MP0003935_abnormal_craniofacial_develop0.93826066
37MP0003942_abnormal_urinary_system0.93169896
38MP0005501_abnormal_skin_physiology0.89116263
39MP0008058_abnormal_DNA_repair0.87187586
40MP0005645_abnormal_hypothalamus_physiol0.83520727
41MP0000490_abnormal_crypts_of0.83397461
42MP0001764_abnormal_homeostasis0.83180081
43MP0000026_abnormal_inner_ear0.82631074
44MP0005197_abnormal_uvea_morphology0.81798665
45MP0005391_vision/eye_phenotype0.80084194
46MP0002019_abnormal_tumor_incidence0.78304142
47MP0000358_abnormal_cell_content/0.77919347
48MP0002184_abnormal_innervation0.77530923
49MP0002697_abnormal_eye_size0.76510254
50MP0001963_abnormal_hearing_physiology0.76304240
51MP0003880_abnormal_central_pattern0.75684051
52MP0000432_abnormal_head_morphology0.72723509
53MP0000470_abnormal_stomach_morphology0.71668779
54MP0000778_abnormal_nervous_system0.71043104
55MP0002115_abnormal_skeleton_extremities0.70595935
56MP0000516_abnormal_urinary_system0.69549606
57MP0005367_renal/urinary_system_phenotyp0.69549606
58MP0002752_abnormal_somatic_nervous0.65927961
59MP0006276_abnormal_autonomic_nervous0.65138383
60MP0006072_abnormal_retinal_apoptosis0.65113959
61MP0002160_abnormal_reproductive_system0.65022501
62MP0005195_abnormal_posterior_eye0.64868668
63MP0000858_altered_metastatic_potential0.64180340
64MP0002210_abnormal_sex_determination0.63524199
65MP0003646_muscle_fatigue0.61819554
66MP0002234_abnormal_pharynx_morphology0.60168504
67MP0004270_analgesia0.57956655
68MP0001175_abnormal_lung_morphology0.56870106
69MP0001529_abnormal_vocalization0.55679056
70MP0000477_abnormal_intestine_morphology0.51874332
71MP0002928_abnormal_bile_duct0.51663709
72MP0000955_abnormal_spinal_cord0.49721411
73MP0002092_abnormal_eye_morphology0.49583739
74MP0008995_early_reproductive_senescence0.48735682
75MP0003632_abnormal_nervous_system0.48108639
76MP0005508_abnormal_skeleton_morphology0.48053254
77MP0008057_abnormal_DNA_replication0.45838153
78MP0005551_abnormal_eye_electrophysiolog0.45426647
79MP0003077_abnormal_cell_cycle0.45042911
80MP0004197_abnormal_fetal_growth/weight/0.43364946
81MP0002882_abnormal_neuron_morphology0.42573540
82MP0003315_abnormal_perineum_morphology0.41950238
83MP0002113_abnormal_skeleton_development0.41907571
84MP0009672_abnormal_birth_weight0.39775103
85MP0002081_perinatal_lethality0.39755797
86MP0002735_abnormal_chemical_nociception0.39602577
87MP0004484_altered_response_of0.39259543
88MP0003329_amyloid_beta_deposits0.38330540
89MP0009046_muscle_twitch0.38303132
90MP0008770_decreased_survivor_rate0.38137079
91MP0005248_abnormal_Harderian_gland0.38111372
92MP0002277_abnormal_respiratory_mucosa0.37354729
93MP0000372_irregular_coat_pigmentation0.36338821
94MP0006054_spinal_hemorrhage0.36294323
95MP0000377_abnormal_hair_follicle0.35594578
96MP0004811_abnormal_neuron_physiology0.34935198
97MP0005423_abnormal_somatic_nervous0.34890451
98MP0001661_extended_life_span0.34110001
99MP0009745_abnormal_behavioral_response0.34013984
100MP0001119_abnormal_female_reproductive0.33803875

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of long-chain fatty-acid metabolism (HP:0010964)9.92498379
2Long foot (HP:0001833)8.36487103
3Duplicated collecting system (HP:0000081)8.07907823
4Abnormality of the renal collecting system (HP:0004742)7.26012388
5Hypoplastic pelvis (HP:0008839)7.01179032
6Large for gestational age (HP:0001520)6.84663170
7Adactyly (HP:0009776)6.83113869
8Acute lymphatic leukemia (HP:0006721)6.14227871
9Dry hair (HP:0011359)5.24466680
10Abnormal auditory evoked potentials (HP:0006958)5.15431929
11Progressive muscle weakness (HP:0003323)4.98162844
12Pulmonary artery stenosis (HP:0004415)4.89576907
13Menstrual irregularities (HP:0000858)4.79688580
14Autoamputation (HP:0001218)4.78425412
15Hypoplastic nipples (HP:0002557)4.76705893
16Ureteral stenosis (HP:0000071)4.75293255
17Abnormality of fatty-acid metabolism (HP:0004359)4.61274430
18Decreased lacrimation (HP:0000633)4.55677800
19Ureteral obstruction (HP:0006000)4.41018291
20Broad-based gait (HP:0002136)4.32261190
21Brushfield spots (HP:0001088)4.12037743
22Increased number of teeth (HP:0011069)4.09145719
23Ureteral duplication (HP:0000073)4.02387452
24Steatorrhea (HP:0002570)3.83417678
25Sudden death (HP:0001699)3.67684723
26Severe muscular hypotonia (HP:0006829)3.63267821
27Abnormal connection of the cardiac segments (HP:0011545)3.48686746
28Abnormal ventriculo-arterial connection (HP:0011563)3.48686746
29Transposition of the great arteries (HP:0001669)3.48686746
30Anhidrosis (HP:0000970)3.40698648
31Reduced subcutaneous adipose tissue (HP:0003758)3.33126356
32Hypoplastic iliac wings (HP:0002866)3.32398362
33Wide intermamillary distance (HP:0006610)3.19211088
34Palmoplantar hyperkeratosis (HP:0000972)3.18138382
35Clubbing of toes (HP:0100760)3.17958393
36Abnormality of vision evoked potentials (HP:0000649)3.11200505
37Palmar hyperkeratosis (HP:0010765)3.09720439
38Polymicrogyria (HP:0002126)3.05050143
39Broad nasal tip (HP:0000455)2.94922134
40Fat malabsorption (HP:0002630)2.94013954
41Decreased muscle mass (HP:0003199)2.93073320
42Large hands (HP:0001176)2.79435983
43Widely spaced teeth (HP:0000687)2.74730584
44Chorioretinal coloboma (HP:0000567)2.70282372
45Polyneuropathy (HP:0001271)2.53909320
46Steppage gait (HP:0003376)2.45475866
47Plantar hyperkeratosis (HP:0007556)2.41365392
48Flat face (HP:0012368)2.36804233
49Septo-optic dysplasia (HP:0100842)2.33365574
50Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.28635601
51Spastic tetraplegia (HP:0002510)2.26328339
52Thickened calvaria (HP:0002684)2.21115413
53Overfolded helix (HP:0000396)2.20507408
54Absent toe (HP:0010760)2.18775520
55Abnormality of the epiphyses of the hand (HP:0005924)2.15776291
56Myoglobinuria (HP:0002913)2.08491516
57Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.02517775
58Epiphyseal stippling (HP:0010655)2.01961066
59Generalized amyotrophy (HP:0003700)2.01359033
60Aplasia/Hypoplasia of the nipples (HP:0006709)2.00443837
61Esophageal atresia (HP:0002032)1.95822022
62Postnatal growth retardation (HP:0008897)1.95704135
63Abnormally folded helix (HP:0008544)1.91835175
64Hypoplastic ilia (HP:0000946)1.88732888
65Female pseudohermaphroditism (HP:0010458)1.84946896
66External ear malformation (HP:0008572)1.82139469
67Progressive cerebellar ataxia (HP:0002073)1.81012100
68Short philtrum (HP:0000322)1.79331006
69Rhabdomyolysis (HP:0003201)1.77701703
70Abnormality of the line of Schwalbe (HP:0008048)1.77592001
71Thickened nuchal skin fold (HP:0000474)1.76379718
72Anxiety (HP:0000739)1.76352926
73Congenital onset (HP:0003577)1.74330793
74Gaze-evoked nystagmus (HP:0000640)1.74028675
75Scrotal hypoplasia (HP:0000046)1.71833128
76Freckling (HP:0001480)1.66939092
77Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.66924338
78Hammertoe (HP:0001765)1.65479181
79Thyroiditis (HP:0100646)1.63973611
80Chronic hepatic failure (HP:0100626)1.61213606
81Posterior embryotoxon (HP:0000627)1.58625155
82Prenatal maternal abnormality (HP:0002686)1.57365275
83Abnormality of the wing of the ilium (HP:0011867)1.55335289
84Abnormal epiphyseal ossification (HP:0010656)1.51271321
85Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.51032809
86Primary adrenal insufficiency (HP:0008207)1.50818781
87Foot dorsiflexor weakness (HP:0009027)1.49483148
88Aqueductal stenosis (HP:0002410)1.48724671
89Hypoplasia of the corpus callosum (HP:0002079)1.47998101
90Generalized muscle weakness (HP:0003324)1.46637973
91Dolichocephaly (HP:0000268)1.43017187
92Optic nerve hypoplasia (HP:0000609)1.42159789
93Decreased testicular size (HP:0008734)1.41411985
94Stereotypic behavior (HP:0000733)1.40540640
95Brachycephaly (HP:0000248)1.39145343
96Dyschromatopsia (HP:0007641)1.38519669
97Basal ganglia calcification (HP:0002135)1.36124920
98Abnormality of the foot musculature (HP:0001436)1.35875809
99Gastrointestinal atresia (HP:0002589)1.33694258
100Oligodactyly (hands) (HP:0001180)1.33030268

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK16.68734486
2TAOK15.16785655
3TAOK25.07518519
4MAP3K114.01573490
5MAP2K33.80127592
6MAP3K33.66859102
7JAK32.17363154
8MKNK211.3654860
9DYRK1A1.88868074
10ABL21.62066430
11FRK1.49019721
12MAP3K51.40897092
13CASK1.17392350
14SRPK11.11875941
15MAP3K10.96473286
16MAP4K20.85628752
17CHEK20.78838482
18MAPK150.64978979
19WNK30.57767377
20FGFR20.56072656
21INSRR0.51714057
22MAP3K40.48868305
23MAP3K80.47117674
24PNCK0.46758375
25PRKCQ0.45744237
26PLK40.45376158
27RPS6KA40.39806533
28MAP2K70.38980872
29OBSCN0.38670409
30TGFBR20.28282023
31TSSK60.28000755
32GRK70.26603502
33PINK10.26568517
34NTRK20.25644165
35BCR0.24826771
36MAPK130.22813177
37CSNK1A10.21145131
38ABL10.18036727
39CDK30.18032645
40MAP2K40.17890354
41MARK10.17353596
42STK38L0.17230505
43BLK0.16357960
44TIE10.16031036
45WEE10.14830108
46IGF1R0.14415873
47PLK20.13662804
48TNIK0.12840788
49STK390.12506435
50ZAK0.12445894
51PAK30.11858293
52AKT30.11418495
53CCNB10.09537059
54VRK10.09418145
55ERBB30.09263126
56ADRBK20.08950174
57CAMKK20.08586588
58OXSR10.07841872
59ACVR1B0.07397784
60IKBKE0.06452456
61FGFR30.06401890
62PIK3CG0.06312992
63ERBB40.05752370
64TRIM280.05486989
65BMPR1B0.04635212
66GRK50.03791150
67TNK20.03758460
68PRKCB0.03284368
69BCKDK0.03274691
70PKN10.02877129
71GRK10.02625321
72PLK30.02469779
73RPS6KA50.02341503
74SGK20.02091283
75PRKCE0.01577530
76ERBB20.01335612
77CSNK2A20.01034699
78DDR20.01016727
79PAK60.00889648
80ADRBK10.00208659
81TXK0.00183691
82EGFR-0.0446850
83LYN-0.0437641
84CAMK1G-0.0413359
85AURKA-0.0344387
86PRKCD-0.0326513
87MUSK-0.0317846
88NTRK3-0.0289198
89CSNK1E-0.0261130
90PRKCA-0.0259629
91CAMK1D-0.0210736
92KDR-0.0208326
93CDC7-0.0189849
94PRKACA-0.0173470
95TEC-0.0169675
96CSNK2A1-0.0120695
97TTK-0.0109839
98KSR1-0.0084511
99PRKCG-0.0063191
100CAMK2A-0.0014826

Predicted pathways (KEGG)

RankGene SetZ-score
1Pantothenate and CoA biosynthesis_Homo sapiens_hsa007707.07899133
2SNARE interactions in vesicular transport_Homo sapiens_hsa041306.87175708
3Lysine degradation_Homo sapiens_hsa003103.06213897
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.04537754
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.98264404
6Butanoate metabolism_Homo sapiens_hsa006502.59169134
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45867644
8RNA polymerase_Homo sapiens_hsa030202.13396666
9Nicotine addiction_Homo sapiens_hsa050332.08138349
10* Taste transduction_Homo sapiens_hsa047422.07334755
11Propanoate metabolism_Homo sapiens_hsa006402.03727387
12Fatty acid elongation_Homo sapiens_hsa000622.00934888
13Tryptophan metabolism_Homo sapiens_hsa003801.86044565
14One carbon pool by folate_Homo sapiens_hsa006701.60504000
15Amoebiasis_Homo sapiens_hsa051461.54128558
16beta-Alanine metabolism_Homo sapiens_hsa004101.53416324
17Glycerolipid metabolism_Homo sapiens_hsa005611.33406452
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26077845
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21245776
20Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16965878
21Systemic lupus erythematosus_Homo sapiens_hsa053221.14244337
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12655622
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11541349
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07394600
25GABAergic synapse_Homo sapiens_hsa047271.06244095
26Olfactory transduction_Homo sapiens_hsa047401.04530195
27Cholinergic synapse_Homo sapiens_hsa047251.04311771
28MicroRNAs in cancer_Homo sapiens_hsa052061.01362593
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01119362
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.01097622
31Morphine addiction_Homo sapiens_hsa050320.94122385
32Caffeine metabolism_Homo sapiens_hsa002320.90815008
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87844493
34Glutamatergic synapse_Homo sapiens_hsa047240.86365112
35Alcoholism_Homo sapiens_hsa050340.82443466
36Steroid biosynthesis_Homo sapiens_hsa001000.78659573
37AMPK signaling pathway_Homo sapiens_hsa041520.75261932
38GnRH signaling pathway_Homo sapiens_hsa049120.73459857
39Hedgehog signaling pathway_Homo sapiens_hsa043400.72675182
40Ovarian steroidogenesis_Homo sapiens_hsa049130.71096259
41Fatty acid degradation_Homo sapiens_hsa000710.70850532
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69751447
43Fatty acid metabolism_Homo sapiens_hsa012120.69596213
44Choline metabolism in cancer_Homo sapiens_hsa052310.69549061
45Proteasome_Homo sapiens_hsa030500.66280878
46Viral myocarditis_Homo sapiens_hsa054160.65856197
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64752412
48Fanconi anemia pathway_Homo sapiens_hsa034600.60312549
49ABC transporters_Homo sapiens_hsa020100.60161014
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.58649350
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53435494
52Basal cell carcinoma_Homo sapiens_hsa052170.53309456
53Oxytocin signaling pathway_Homo sapiens_hsa049210.52626597
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.52340534
55Serotonergic synapse_Homo sapiens_hsa047260.51914888
56Complement and coagulation cascades_Homo sapiens_hsa046100.51828125
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51301896
58Nucleotide excision repair_Homo sapiens_hsa034200.50689402
59Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49901012
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.49863919
61Calcium signaling pathway_Homo sapiens_hsa040200.49666388
62Dopaminergic synapse_Homo sapiens_hsa047280.48815180
63Renin secretion_Homo sapiens_hsa049240.45536260
64Epstein-Barr virus infection_Homo sapiens_hsa051690.44742108
65Peroxisome_Homo sapiens_hsa041460.44573400
66Linoleic acid metabolism_Homo sapiens_hsa005910.44388406
67TNF signaling pathway_Homo sapiens_hsa046680.43897343
68Circadian entrainment_Homo sapiens_hsa047130.42919221
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42367875
70Gap junction_Homo sapiens_hsa045400.40668819
71Cocaine addiction_Homo sapiens_hsa050300.39672405
72Melanogenesis_Homo sapiens_hsa049160.39668505
73Melanoma_Homo sapiens_hsa052180.39628011
74Phototransduction_Homo sapiens_hsa047440.37471919
75Salmonella infection_Homo sapiens_hsa051320.37119662
76Toxoplasmosis_Homo sapiens_hsa051450.34318556
77MAPK signaling pathway_Homo sapiens_hsa040100.33595454
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33224236
79Retinol metabolism_Homo sapiens_hsa008300.32620046
80Type II diabetes mellitus_Homo sapiens_hsa049300.31758342
81Rap1 signaling pathway_Homo sapiens_hsa040150.31700882
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30496574
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29715758
84Amphetamine addiction_Homo sapiens_hsa050310.25461211
85Ether lipid metabolism_Homo sapiens_hsa005650.25071535
86RNA transport_Homo sapiens_hsa030130.22584428
87cAMP signaling pathway_Homo sapiens_hsa040240.21821650
88Oocyte meiosis_Homo sapiens_hsa041140.21714758
89Axon guidance_Homo sapiens_hsa043600.20562336
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20400069
91Dilated cardiomyopathy_Homo sapiens_hsa054140.20194888
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19920759
93Tuberculosis_Homo sapiens_hsa051520.19597395
94Purine metabolism_Homo sapiens_hsa002300.19223547
95ECM-receptor interaction_Homo sapiens_hsa045120.18285634
96Protein digestion and absorption_Homo sapiens_hsa049740.15914100
97Estrogen signaling pathway_Homo sapiens_hsa049150.15363216
98Chemical carcinogenesis_Homo sapiens_hsa052040.15350320
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.14812746
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13923149

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