TAS2R20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the taste receptor two family of class C G-protein coupled receptors. Receptors of this family have a short extracellular N-terminus, seven transmembrane helices, three extracellular loops and three intracellular loops, and an intracellular C-terminus. Members of this family are expressed in a subset of taste receptor cells, where they function in bitter taste reception, as well as in non-gustatory cells including those of the brain, reproductive organs, respiratory system, and gastrointestinal system. This gene maps to the taste receptor gene cluster on chromosome 12p13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H2A acetylation (GO:0043968)9.71259258
2phosphate ion transport (GO:0006817)7.59700811
3peptidyl-tyrosine autophosphorylation (GO:0038083)6.92430583
4regulation of RNA export from nucleus (GO:0046831)6.58326002
5nuclear pore complex assembly (GO:0051292)5.93502130
6phosphate ion transmembrane transport (GO:0035435)5.69167133
7regulation of hippo signaling (GO:0035330)5.69129555
8regulation of pigment cell differentiation (GO:0050932)5.60259047
9urate metabolic process (GO:0046415)5.58311200
10positive regulation of developmental pigmentation (GO:0048087)5.47380605
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.23423268
12regulation of nucleobase-containing compound transport (GO:0032239)5.06037205
13nuclear pore organization (GO:0006999)4.78963997
14negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.38696298
15negative regulation of translation, ncRNA-mediated (GO:0040033)4.38696298
16regulation of translation, ncRNA-mediated (GO:0045974)4.38696298
17positive regulation of dendritic spine morphogenesis (GO:0061003)4.16007266
18protein prenylation (GO:0018342)4.09563185
19prenylation (GO:0097354)4.09563185
20pore complex assembly (GO:0046931)4.03182449
21response to parathyroid hormone (GO:0071107)3.99189793
22negative regulation of cAMP-mediated signaling (GO:0043951)3.99174682
23tachykinin receptor signaling pathway (GO:0007217)3.96181067
24neural tube formation (GO:0001841)3.83440949
25meiotic chromosome segregation (GO:0045132)3.80816271
26regulation of mitotic spindle checkpoint (GO:1903504)3.75253633
27regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.75253633
28pericardium development (GO:0060039)3.67834342
29positive regulation of histone H3-K4 methylation (GO:0051571)3.67767185
30histone mRNA metabolic process (GO:0008334)3.58928729
31negative regulation of protein localization to cell surface (GO:2000009)3.58368439
32energy homeostasis (GO:0097009)3.54301634
33positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.41223138
34protein K48-linked deubiquitination (GO:0071108)3.40643730
35histone mRNA catabolic process (GO:0071044)3.37416174
36negative regulation of DNA repair (GO:0045738)3.35787574
37central nervous system neuron axonogenesis (GO:0021955)3.24615965
38positive regulation of CREB transcription factor activity (GO:0032793)3.22230886
39regulation of natural killer cell differentiation (GO:0032823)3.20263047
40positive regulation of heart rate (GO:0010460)3.19553937
41gene silencing by RNA (GO:0031047)3.14771562
42detection of other organism (GO:0098543)3.12196911
43positive regulation of protein export from nucleus (GO:0046827)3.11396568
44detection of bacterium (GO:0016045)3.09184062
45aminoglycoside antibiotic metabolic process (GO:0030647)3.08474401
46cellular response to nitric oxide (GO:0071732)3.08213759
47mitochondrion distribution (GO:0048311)3.07237497
48monoubiquitinated protein deubiquitination (GO:0035520)3.02527092
49negative regulation of dendrite development (GO:2000171)3.02340699
50histone H4 acetylation (GO:0043967)3.00074767
51bone remodeling (GO:0046849)2.99165005
52phosphate ion homeostasis (GO:0055062)2.95950661
53trivalent inorganic anion homeostasis (GO:0072506)2.95950661
54positive regulation of uterine smooth muscle contraction (GO:0070474)2.95685960
55folic acid metabolic process (GO:0046655)2.94525263
56cerebral cortex radially oriented cell migration (GO:0021799)2.94205836
57cytoplasmic mRNA processing body assembly (GO:0033962)2.92819152
58behavioral response to nicotine (GO:0035095)2.92726102
59central nervous system projection neuron axonogenesis (GO:0021952)2.91094064
60transmission of nerve impulse (GO:0019226)2.90025452
61cellular response to ethanol (GO:0071361)2.85407351
62cellular response to reactive nitrogen species (GO:1902170)2.79801239
63positive regulation of dendrite morphogenesis (GO:0050775)2.79232816
64regulation of uterine smooth muscle contraction (GO:0070472)2.78962201
65ether lipid metabolic process (GO:0046485)2.78949755
66limb bud formation (GO:0060174)2.76973450
67regulation of centriole replication (GO:0046599)2.76195219
68peristalsis (GO:0030432)2.75400741
69establishment of nucleus localization (GO:0040023)2.75175875
70cell migration in hindbrain (GO:0021535)2.74576523
71response to mercury ion (GO:0046689)2.67903709
72regulation of Golgi to plasma membrane protein transport (GO:0042996)2.65365412
73response to growth hormone (GO:0060416)2.62841189
74head development (GO:0060322)2.62491446
75detection of light stimulus involved in visual perception (GO:0050908)2.61782618
76detection of light stimulus involved in sensory perception (GO:0050962)2.61782618
77response to lead ion (GO:0010288)2.60124273
78regulation of histone H3-K4 methylation (GO:0051569)2.57317619
79regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.55548752
80regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.55548752
81response to magnesium ion (GO:0032026)2.51281972
82positive regulation of protein kinase C signaling (GO:0090037)2.50741569
83glycoprotein catabolic process (GO:0006516)2.50054313
84adult heart development (GO:0007512)2.49449342
85positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.47479120
86histone H4-K12 acetylation (GO:0043983)2.47346358
87negative regulation of Rho protein signal transduction (GO:0035024)2.46351763
88positive regulation of cell cycle checkpoint (GO:1901978)2.44804614
89positive regulation of signal transduction by p53 class mediator (GO:1901798)2.44382708
90maternal behavior (GO:0042711)2.44207604
91endosome to melanosome transport (GO:0035646)2.43910659
92endosome to pigment granule transport (GO:0043485)2.43910659
93negative regulation of JAK-STAT cascade (GO:0046426)2.43703040
94hyperosmotic salinity response (GO:0042538)2.43549959
95parental behavior (GO:0060746)2.41940966
96protein K63-linked deubiquitination (GO:0070536)2.41903436
97negative regulation of gene expression, epigenetic (GO:0045814)2.41627222
98dorsal/ventral axis specification (GO:0009950)2.40990753
99regulation of sarcomere organization (GO:0060297)2.40888317
100Golgi to endosome transport (GO:0006895)2.39355578

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human9.68532414
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.71115040
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.47274191
4GBX2_23144817_ChIP-Seq_PC3_Human2.94880894
5FUS_26573619_Chip-Seq_HEK293_Human2.48858462
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47573125
7ZNF274_21170338_ChIP-Seq_K562_Hela2.32780483
8SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.23516200
9AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.09791799
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06709487
11E2F7_22180533_ChIP-Seq_HELA_Human1.93321068
12STAT3_23295773_ChIP-Seq_U87_Human1.90525004
13EZH2_22144423_ChIP-Seq_EOC_Human1.88074426
14EWS_26573619_Chip-Seq_HEK293_Human1.84692389
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74668616
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74315244
17VDR_22108803_ChIP-Seq_LS180_Human1.72564867
18SMAD4_21799915_ChIP-Seq_A2780_Human1.71724186
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.71586116
20WT1_19549856_ChIP-ChIP_CCG9911_Human1.67582472
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64874909
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64288972
23UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60987922
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60405175
25P300_19829295_ChIP-Seq_ESCs_Human1.59923906
26CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.57694280
27ER_23166858_ChIP-Seq_MCF-7_Human1.55966234
28TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52272788
29TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.50431286
30NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49771758
31IGF1R_20145208_ChIP-Seq_DFB_Human1.47592995
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40708354
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39938505
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.39485431
35RUNX2_22187159_ChIP-Seq_PCA_Human1.39381406
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.39379505
37TAF15_26573619_Chip-Seq_HEK293_Human1.37897371
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37395557
39AR_25329375_ChIP-Seq_VCAP_Human1.37140997
40PRDM14_20953172_ChIP-Seq_ESCs_Human1.36502904
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36184602
42E2F1_18555785_Chip-Seq_ESCs_Mouse1.35766119
43TCF4_23295773_ChIP-Seq_U87_Human1.33318640
44RUNX_20019798_ChIP-Seq_JUKART_Human1.32736889
45AR_21572438_ChIP-Seq_LNCaP_Human1.31880683
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31137653
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30760212
48FLI1_21867929_ChIP-Seq_TH2_Mouse1.30739262
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.30577248
50ELK1_19687146_ChIP-ChIP_HELA_Human1.30157011
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29446966
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.29162481
53CMYC_18555785_Chip-Seq_ESCs_Mouse1.28522145
54TP53_16413492_ChIP-PET_HCT116_Human1.27693557
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.27026149
56RXR_22108803_ChIP-Seq_LS180_Human1.26469410
57TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.24105679
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23499138
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23499138
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.22135371
61AHR_22903824_ChIP-Seq_MCF-7_Human1.20983837
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20038632
63CBP_20019798_ChIP-Seq_JUKART_Human1.16767589
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16767589
65OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16548600
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15330461
67SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12730389
68P300_18555785_Chip-Seq_ESCs_Mouse1.12285946
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.12054298
70MYC_18940864_ChIP-ChIP_HL60_Human1.11461421
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09600332
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.09324270
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08477193
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07283652
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06570235
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05720998
77FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05629972
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.05212314
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04422129
80KDM2B_26808549_Chip-Seq_REH_Human1.02013417
81P53_22387025_ChIP-Seq_ESCs_Mouse1.01898788
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99211234
83SOX2_18555785_Chip-Seq_ESCs_Mouse0.98744745
84TCF4_22108803_ChIP-Seq_LS180_Human0.98351633
85FOXM1_23109430_ChIP-Seq_U2OS_Human0.98269925
86STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97989787
87STAT3_18555785_Chip-Seq_ESCs_Mouse0.97842913
88KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96489918
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95965641
90ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95585129
91FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94732725
92SMAD4_21741376_ChIP-Seq_EPCs_Human0.94730002
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94411707
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94337754
95IRF8_22096565_ChIP-ChIP_GC-B_Human0.93586376
96GATA1_26923725_Chip-Seq_HPCs_Mouse0.91702434
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91290001
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90692892
99JUN_21703547_ChIP-Seq_K562_Human0.90485294
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88818595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.82240322
2MP0005397_hematopoietic_system_phenotyp3.50896549
3MP0001545_abnormal_hematopoietic_system3.50896549
4MP0008057_abnormal_DNA_replication3.41297227
5MP0004808_abnormal_hematopoietic_stem3.23778136
6MP0002009_preneoplasia3.12020162
7MP0010352_gastrointestinal_tract_polyps2.95673045
8MP0004147_increased_porphyrin_level2.79302053
9MP0003878_abnormal_ear_physiology2.51645297
10MP0005377_hearing/vestibular/ear_phenot2.51645297
11MP0000427_abnormal_hair_cycle2.50319288
12MP0003045_fibrosis2.40055591
13MP0002332_abnormal_exercise_endurance2.22257612
14MP0006054_spinal_hemorrhage2.13330917
15MP0000383_abnormal_hair_follicle2.10549998
16MP0004484_altered_response_of2.06185204
17MP0005645_abnormal_hypothalamus_physiol2.05920306
18MP0010678_abnormal_skin_adnexa2.04204904
19MP0003763_abnormal_thymus_physiology1.87552632
20MP0002168_other_aberrant_phenotype1.86382622
21MP0001486_abnormal_startle_reflex1.82906088
22MP0002396_abnormal_hematopoietic_system1.80291353
23MP0008877_abnormal_DNA_methylation1.74611335
24MP0005551_abnormal_eye_electrophysiolog1.74438719
25MP0003195_calcinosis1.69858276
26MP0010234_abnormal_vibrissa_follicle1.61931625
27MP0010094_abnormal_chromosome_stability1.61486295
28MP0004510_myositis1.55252211
29MP0003943_abnormal_hepatobiliary_system1.53478876
30MP0003221_abnormal_cardiomyocyte_apopto1.49903001
31MP0005409_darkened_coat_color1.46833624
32MP0003890_abnormal_embryonic-extraembry1.42460576
33MP0004215_abnormal_myocardial_fiber1.37494104
34MP0006138_congestive_heart_failure1.37274366
35MP0009672_abnormal_birth_weight1.28824998
36MP0003111_abnormal_nucleus_morphology1.26807991
37MP0002166_altered_tumor_susceptibility1.26189364
38MP0004085_abnormal_heartbeat1.22120976
39MP0000749_muscle_degeneration1.21280149
40MP0005195_abnormal_posterior_eye1.20772541
41MP0000015_abnormal_ear_pigmentation1.17755254
42MP0004145_abnormal_muscle_electrophysio1.17039465
43MP0002735_abnormal_chemical_nociception1.15693962
44MP0009697_abnormal_copulation1.14870690
45MP0002971_abnormal_brown_adipose1.13472010
46MP0005220_abnormal_exocrine_pancreas1.11167916
47MP0002160_abnormal_reproductive_system1.08359492
48MP0002138_abnormal_hepatobiliary_system1.07547405
49MP0000372_irregular_coat_pigmentation1.06517940
50MP0005253_abnormal_eye_physiology1.04137791
51MP0006035_abnormal_mitochondrial_morpho1.03694231
52MP0002184_abnormal_innervation1.02766297
53MP0003941_abnormal_skin_development0.99737840
54MP0005174_abnormal_tail_pigmentation0.99640371
55MP0001293_anophthalmia0.98267252
56MP0005171_absent_coat_pigmentation0.96999426
57MP0000778_abnormal_nervous_system0.95989759
58MP0009703_decreased_birth_body0.95215813
59MP0008775_abnormal_heart_ventricle0.93674674
60MP0000371_diluted_coat_color0.92988609
61MP0000358_abnormal_cell_content/0.92510925
62MP0003984_embryonic_growth_retardation0.91888373
63MP0002006_tumorigenesis0.90544103
64MP0002088_abnormal_embryonic_growth/wei0.89058582
65MP0004084_abnormal_cardiac_muscle0.88869932
66MP0003935_abnormal_craniofacial_develop0.86704239
67MP0005395_other_phenotype0.86698562
68MP0004043_abnormal_pH_regulation0.86653609
69MP0005367_renal/urinary_system_phenotyp0.86617135
70MP0000516_abnormal_urinary_system0.86617135
71MP0006072_abnormal_retinal_apoptosis0.86510076
72MP0010307_abnormal_tumor_latency0.85910909
73MP0008260_abnormal_autophagy0.82517455
74MP0009115_abnormal_fat_cell0.82136572
75MP0004270_analgesia0.81730179
76MP0000377_abnormal_hair_follicle0.79839917
77MP0003183_abnormal_peptide_metabolism0.79410648
78MP0002086_abnormal_extraembryonic_tissu0.77494138
79MP0000747_muscle_weakness0.77297406
80MP0005647_abnormal_sex_gland0.75138572
81MP0003937_abnormal_limbs/digits/tail_de0.74214985
82MP0003137_abnormal_impulse_conducting0.73656306
83MP0003077_abnormal_cell_cycle0.73533799
84MP0003172_abnormal_lysosome_physiology0.72730119
85MP0005266_abnormal_metabolism0.72504324
86MP0002928_abnormal_bile_duct0.69708921
87MP0002084_abnormal_developmental_patter0.69179459
88MP0001764_abnormal_homeostasis0.67657565
89MP0004130_abnormal_muscle_cell0.67187192
90MP0005310_abnormal_salivary_gland0.65463436
91MP0001672_abnormal_embryogenesis/_devel0.65020585
92MP0005380_embryogenesis_phenotype0.65020585
93MP0001915_intracranial_hemorrhage0.64915370
94MP0005391_vision/eye_phenotype0.64345572
95MP0001879_abnormal_lymphatic_vessel0.63089491
96MP0000955_abnormal_spinal_cord0.62675946
97MP0005319_abnormal_enzyme/_coenzyme0.61977173
98MP0002229_neurodegeneration0.60932022
99MP0002752_abnormal_somatic_nervous0.60278792
100MP0003567_abnormal_fetal_cardiomyocyte0.59739207

Predicted human phenotypes

RankGene SetZ-score
1Pendular nystagmus (HP:0012043)5.46245456
2Proximal tubulopathy (HP:0000114)4.94925018
3Generalized aminoaciduria (HP:0002909)4.93902919
4Hyperventilation (HP:0002883)3.55668143
5Severe visual impairment (HP:0001141)3.50851826
6Abnormality of homocysteine metabolism (HP:0010919)3.40750460
7Homocystinuria (HP:0002156)3.40750460
8Short chin (HP:0000331)3.39716524
9Fair hair (HP:0002286)3.36290733
10Action tremor (HP:0002345)3.34515521
11Cystic hygroma (HP:0000476)3.31709683
12Long clavicles (HP:0000890)3.23537629
13Scanning speech (HP:0002168)3.19475956
14Congenital stationary night blindness (HP:0007642)3.09614143
15Genetic anticipation (HP:0003743)2.95328808
16Acute lymphatic leukemia (HP:0006721)2.88354819
17Pancreatic fibrosis (HP:0100732)2.85123968
18Keratoconus (HP:0000563)2.80754847
19Increased corneal curvature (HP:0100692)2.80754847
20Protruding tongue (HP:0010808)2.79684342
21Biliary tract neoplasm (HP:0100574)2.78424073
22Renal cortical cysts (HP:0000803)2.73249161
23Pancreatic cysts (HP:0001737)2.67791159
24Submucous cleft hard palate (HP:0000176)2.67769002
25Genital tract atresia (HP:0001827)2.58016183
26True hermaphroditism (HP:0010459)2.54827938
27Attenuation of retinal blood vessels (HP:0007843)2.54449246
28Cupped ear (HP:0000378)2.53233868
29Chorioretinal atrophy (HP:0000533)2.50602870
30Broad-based gait (HP:0002136)2.48139093
31Vaginal atresia (HP:0000148)2.47428773
32Abnormality of chromosome stability (HP:0003220)2.47139877
33Ectopic kidney (HP:0000086)2.46344335
34Skull defect (HP:0001362)2.44841263
35Popliteal pterygium (HP:0009756)2.40991752
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.34903904
37Postaxial foot polydactyly (HP:0001830)2.28502084
38Thyroiditis (HP:0100646)2.27672657
39Acanthocytosis (HP:0001927)2.27465394
40Abolished electroretinogram (ERG) (HP:0000550)2.27280374
41Generalized hypopigmentation of hair (HP:0011358)2.17042711
42Drooling (HP:0002307)2.14387468
43Abnormality of the sella turcica (HP:0002679)2.13736520
44Abnormal lung lobation (HP:0002101)2.09868262
45Poor eye contact (HP:0000817)2.08230699
46Gaze-evoked nystagmus (HP:0000640)2.05937908
47Bilateral microphthalmos (HP:0007633)2.05704955
48Excessive salivation (HP:0003781)2.01921864
49Abnormality of DNA repair (HP:0003254)2.01570073
50Decreased lacrimation (HP:0000633)1.99774759
51Abnormality of the renal cortex (HP:0011035)1.97340934
52Neoplasm of the small intestine (HP:0100833)1.95068711
53Absent eyebrow (HP:0002223)1.93517308
54Aplasia/Hypoplasia of the tongue (HP:0010295)1.93360551
55Midline defect of the nose (HP:0004122)1.92070168
56Mask-like facies (HP:0000298)1.90197158
57Chronic hepatic failure (HP:0100626)1.89884548
58Urethral obstruction (HP:0000796)1.89276925
59Termporal pattern (HP:0011008)1.86771244
60Insidious onset (HP:0003587)1.86771244
61Abnormality of the labia majora (HP:0012881)1.86252162
62Morphological abnormality of the middle ear (HP:0008609)1.84837260
63Poikiloderma (HP:0001029)1.83120455
64Medial flaring of the eyebrow (HP:0010747)1.83042645
65Cutaneous finger syndactyly (HP:0010554)1.83033262
66Congenital primary aphakia (HP:0007707)1.80201948
67J-shaped sella turcica (HP:0002680)1.79687544
68Hyperkalemia (HP:0002153)1.74995924
69Bladder neoplasm (HP:0009725)1.74575428
70Bladder carcinoma (HP:0002862)1.74575428
71Chronic diarrhea (HP:0002028)1.74445213
72Small hand (HP:0200055)1.72757513
73Dysdiadochokinesis (HP:0002075)1.72714571
74Sloping forehead (HP:0000340)1.71749903
75Abnormality of the lumbar spine (HP:0100712)1.71604921
76Truncal obesity (HP:0001956)1.71553064
77Clumsiness (HP:0002312)1.69063781
78Decreased central vision (HP:0007663)1.68927282
79Arteriovenous malformation (HP:0100026)1.67560388
80Abnormality of the pubic bones (HP:0003172)1.67544392
81Cystic liver disease (HP:0006706)1.66914083
82Curly hair (HP:0002212)1.66021644
83Congenital hepatic fibrosis (HP:0002612)1.66000410
84Atonic seizures (HP:0010819)1.65887665
85Gait imbalance (HP:0002141)1.65575275
86Sclerocornea (HP:0000647)1.64679367
87Agnosia (HP:0010524)1.64141584
88Sandal gap (HP:0001852)1.63098250
89Pulmonary hypoplasia (HP:0002089)1.62878225
90Optic nerve hypoplasia (HP:0000609)1.61451574
91Exotropia (HP:0000577)1.61321471
92Hypoglycemic coma (HP:0001325)1.60584086
93Volvulus (HP:0002580)1.60110478
94Constricted visual fields (HP:0001133)1.58557746
95Widely spaced teeth (HP:0000687)1.58033350
96Gonadotropin excess (HP:0000837)1.56773586
97Abnormal biliary tract morphology (HP:0012440)1.56108027
98Cone-rod dystrophy (HP:0000548)1.55103427
99Smooth philtrum (HP:0000319)1.53962283
100Neoplasm of the rectum (HP:0100743)1.53563301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.46872904
2MAP3K64.85723687
3MAP3K44.39372708
4MAP2K73.28534984
5ACVR1B3.07707223
6PINK12.69317938
7MAP3K102.67859508
8BMPR1B2.33723134
9MKNK22.17791516
10BRD42.15639967
11WNK32.08718551
12MAP2K42.03429117
13ADRBK21.90884741
14YES11.81725524
15CDK191.51013346
16FGFR21.50889448
17BLK1.50427349
18STK391.45206818
19NEK91.31917094
20MAP3K51.28194305
21TXK1.19711482
22WNK41.19170328
23NLK1.13121958
24MKNK11.06480829
25RET1.05122598
26TRPM71.04720817
27OBSCN1.03488742
28PDGFRA1.02230393
29PBK1.01822846
30PLK40.99265661
31STK30.99085963
32SGK20.98434679
33PDGFRB0.97951298
34GRK70.94410515
35MAPK130.90036677
36TEC0.89518356
37PTK2B0.89135432
38ERBB30.85755036
39SGK30.85588734
40CCNB10.83705636
41FGFR30.82525830
42CDK60.79405431
43KSR10.78753462
44MAP3K70.76154061
45DAPK20.72234229
46FGR0.71449923
47CHEK20.71397092
48PLK20.68567901
49SRPK10.68565947
50CDK120.68545899
51MAP4K10.65363332
52WNK10.62125257
53BTK0.61412017
54PNCK0.59282776
55CHEK10.57531025
56TGFBR20.57328209
57JAK30.56705465
58SYK0.56689403
59GRK10.54374187
60SCYL20.52875749
61STK110.52321393
62ATM0.51455174
63CAMK40.51399108
64TGFBR10.50904083
65SGK10.50262582
66CAMK1G0.49818716
67CASK0.49756648
68MAPK100.49190015
69JAK20.48627461
70PRKACB0.48238900
71CDK40.48021782
72TNIK0.46676484
73CDK10.46617473
74ADRBK10.46276855
75AKT30.46195828
76CSNK1G10.46139033
77KSR20.44178865
78TLK10.43129140
79ATR0.42562249
80MAPK80.42347928
81ZAK0.41831639
82INSR0.41109644
83MAPK70.40790996
84LYN0.40687779
85TYRO30.40609714
86EIF2AK30.40277878
87RPS6KB20.39460623
88TAOK30.39457557
89CDC70.39142715
90RPS6KA40.38518743
91EGFR0.38445195
92MET0.38352194
93MELK0.38288900
94GSK3B0.36401722
95NTRK30.34296008
96EPHA40.33843722
97ERBB20.32999250
98RPS6KB10.32736717
99JAK10.31932770
100MAP4K20.31904851

Predicted pathways (KEGG)

RankGene SetZ-score
1Renin-angiotensin system_Homo sapiens_hsa046144.36070355
2Nicotine addiction_Homo sapiens_hsa050332.49172722
3Selenocompound metabolism_Homo sapiens_hsa004502.33694328
4Non-homologous end-joining_Homo sapiens_hsa034502.11012417
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08435779
6Phototransduction_Homo sapiens_hsa047441.91223151
7Homologous recombination_Homo sapiens_hsa034401.74824743
8Adipocytokine signaling pathway_Homo sapiens_hsa049201.63965375
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.55528351
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53937371
11Butanoate metabolism_Homo sapiens_hsa006501.53398866
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46827170
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.44797804
14FoxO signaling pathway_Homo sapiens_hsa040681.42113037
15* Taste transduction_Homo sapiens_hsa047421.34941339
16Dorso-ventral axis formation_Homo sapiens_hsa043201.30610911
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.29648832
18Vitamin digestion and absorption_Homo sapiens_hsa049771.24135370
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23760857
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19881886
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19097169
22Circadian rhythm_Homo sapiens_hsa047101.18338305
23Morphine addiction_Homo sapiens_hsa050321.16499126
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14987149
25Fanconi anemia pathway_Homo sapiens_hsa034601.11956169
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11491036
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11058834
28ABC transporters_Homo sapiens_hsa020101.10227707
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09187198
30Retinol metabolism_Homo sapiens_hsa008301.06119709
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06009950
32Type II diabetes mellitus_Homo sapiens_hsa049301.03206892
33Alcoholism_Homo sapiens_hsa050341.02261523
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01718257
35cAMP signaling pathway_Homo sapiens_hsa040240.98969817
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98488265
37One carbon pool by folate_Homo sapiens_hsa006700.98368991
38Glutamatergic synapse_Homo sapiens_hsa047240.96463656
39Systemic lupus erythematosus_Homo sapiens_hsa053220.91313548
40Choline metabolism in cancer_Homo sapiens_hsa052310.91138901
41MicroRNAs in cancer_Homo sapiens_hsa052060.91124404
42Colorectal cancer_Homo sapiens_hsa052100.89974918
43RNA transport_Homo sapiens_hsa030130.88768247
44Nitrogen metabolism_Homo sapiens_hsa009100.86747540
45Platelet activation_Homo sapiens_hsa046110.86101566
46Calcium signaling pathway_Homo sapiens_hsa040200.85591542
47Axon guidance_Homo sapiens_hsa043600.84877361
48Thyroid cancer_Homo sapiens_hsa052160.81450453
49Insulin resistance_Homo sapiens_hsa049310.76924231
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76689151
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.76301911
52Prolactin signaling pathway_Homo sapiens_hsa049170.76061558
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75112860
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.73974806
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73780995
56Gap junction_Homo sapiens_hsa045400.71340377
57GABAergic synapse_Homo sapiens_hsa047270.68889969
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68820621
59Renin secretion_Homo sapiens_hsa049240.68325429
60Starch and sucrose metabolism_Homo sapiens_hsa005000.67777735
61Steroid biosynthesis_Homo sapiens_hsa001000.67585293
62Circadian entrainment_Homo sapiens_hsa047130.67281750
63Oxytocin signaling pathway_Homo sapiens_hsa049210.66936798
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.60882388
65Long-term potentiation_Homo sapiens_hsa047200.60793297
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60533914
67Adherens junction_Homo sapiens_hsa045200.59998611
68Cocaine addiction_Homo sapiens_hsa050300.59442530
69Cell cycle_Homo sapiens_hsa041100.59336579
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58920131
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58416906
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58335636
73Ras signaling pathway_Homo sapiens_hsa040140.57351040
74Pancreatic cancer_Homo sapiens_hsa052120.57242156
75African trypanosomiasis_Homo sapiens_hsa051430.56864864
76Mismatch repair_Homo sapiens_hsa034300.56519800
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56286911
78Fatty acid metabolism_Homo sapiens_hsa012120.55450522
79Lysine degradation_Homo sapiens_hsa003100.55274812
80ErbB signaling pathway_Homo sapiens_hsa040120.55082419
81Chemical carcinogenesis_Homo sapiens_hsa052040.53720711
82Fatty acid biosynthesis_Homo sapiens_hsa000610.53545560
83Complement and coagulation cascades_Homo sapiens_hsa046100.53350301
84Cholinergic synapse_Homo sapiens_hsa047250.53312636
85Hedgehog signaling pathway_Homo sapiens_hsa043400.52639792
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52349918
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51706800
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51140591
89B cell receptor signaling pathway_Homo sapiens_hsa046620.49371348
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49173574
91Melanoma_Homo sapiens_hsa052180.47439574
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46601308
93Long-term depression_Homo sapiens_hsa047300.46383254
94Dopaminergic synapse_Homo sapiens_hsa047280.45292228
95TGF-beta signaling pathway_Homo sapiens_hsa043500.43388813
96GnRH signaling pathway_Homo sapiens_hsa049120.42601858
97Rap1 signaling pathway_Homo sapiens_hsa040150.42349983
98Chronic myeloid leukemia_Homo sapiens_hsa052200.42204343
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41281320
100Salivary secretion_Homo sapiens_hsa049700.41191194

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