ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	polyamine biosynthetic process (GO:0006596)	8.82263138
2	negative regulation of homotypic cell-cell adhesion (GO:0034111)	8.29160659
3	cardiolipin metabolic process (GO:0032048)	7.03171344
4	negative regulation of thymocyte apoptotic process (GO:0070244)	6.86017779
5	positive regulation of endothelial cell differentiation (GO:0045603)	6.65608196
6	cellular biogenic amine biosynthetic process (GO:0042401)	6.59767743
7	regulation of platelet aggregation (GO:0090330)	6.41065835
8	amine biosynthetic process (GO:0009309)	6.21979430
9	cellular biogenic amine catabolic process (GO:0042402)	5.93211145
10	amine catabolic process (GO:0009310)	5.93211145
11	retinal cone cell development (GO:0046549)	5.73147710
12	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	5.46000206
13	negative regulation of appetite (GO:0032099)	5.44576740
14	negative regulation of response to food (GO:0032096)	5.44576740
15	lipoxygenase pathway (GO:0019372)	5.42799653
16	long-chain fatty acid biosynthetic process (GO:0042759)	5.35648730
17	positive regulation of cAMP-mediated signaling (GO:0043950)	5.19050439
18	urate metabolic process (GO:0046415)	5.19036598
19	polyamine metabolic process (GO:0006595)	5.11339077
20	relaxation of smooth muscle (GO:0044557)	5.05123107
21	regulation of DNA methylation (GO:0044030)	5.02413796
22	negative regulation of platelet activation (GO:0010544)	4.97880588
23	regulation of platelet activation (GO:0010543)	4.88740214
24	negative regulation of heart rate (GO:0010459)	4.79856975
25	positive regulation of insulin receptor signaling pathway (GO:0046628)	4.58605828
26	regulation of endothelial cell differentiation (GO:0045601)	4.45746105
27	arginine catabolic process (GO:0006527)	4.42749737
28	regulation of integrin activation (GO:0033623)	4.42571183
29	N-terminal protein amino acid acetylation (GO:0006474)	4.33878094
30	regulation of MHC class II biosynthetic process (GO:0045346)	4.30124893
31	type B pancreatic cell proliferation (GO:0044342)	4.27820721
32	regulation of sensory perception (GO:0051931)	4.18309655
33	regulation of sensory perception of pain (GO:0051930)	4.18309655
34	piRNA metabolic process (GO:0034587)	4.17852766
35	ADP metabolic process (GO:0046031)	4.16175619
36	modulation by virus of host process (GO:0019054)	4.13544656
37	establishment of skin barrier (GO:0061436)	4.04924567
38	regulation of female gonad development (GO:2000194)	4.00624184
39	linoleic acid metabolic process (GO:0043651)	4.00200282
40	regulation of homotypic cell-cell adhesion (GO:0034110)	3.95743012
41	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.91642680
42	positive regulation of B cell differentiation (GO:0045579)	3.78144311
43	superoxide anion generation (GO:0042554)	3.71520635
44	midbrain development (GO:0030901)	3.67767709
45	carnitine metabolic process (GO:0009437)	3.64297218
46	regulation of thymocyte apoptotic process (GO:0070243)	3.64063053
47	transmission of nerve impulse (GO:0019226)	3.60086432
48	neutrophil activation involved in immune response (GO:0002283)	3.59765010
49	icosanoid biosynthetic process (GO:0046456)	3.59478562
50	fatty acid derivative biosynthetic process (GO:1901570)	3.59478562
51	dopamine transport (GO:0015872)	3.59347402
52	regulation of meiosis I (GO:0060631)	3.58891763
53	male meiosis I (GO:0007141)	3.57406382
54	platelet aggregation (GO:0070527)	3.52344437
55	regulation of appetite (GO:0032098)	3.39662214
56	DNA synthesis involved in DNA repair (GO:0000731)	3.38006150
57	positive regulation of macrophage differentiation (GO:0045651)	3.37751608
58	positive regulation of systemic arterial blood pressure (GO:0003084)	3.36294696
59	regulation of cAMP-mediated signaling (GO:0043949)	3.35719962
60	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.32963372
61	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.32963372
62	regulation of response to food (GO:0032095)	3.32431786
63	regulation of glucokinase activity (GO:0033131)	3.32332655
64	regulation of hexokinase activity (GO:1903299)	3.32332655
65	DNA methylation involved in gamete generation (GO:0043046)	3.28408665
66	negative regulation of smooth muscle contraction (GO:0045986)	3.26084637
67	cellular response to nicotine (GO:0071316)	3.24428020
68	regulation of hypersensitivity (GO:0002883)	3.20124724
69	snRNA transcription (GO:0009301)	3.16648341
70	regulation of water loss via skin (GO:0033561)	3.14428444
71	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.13870226
72	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.13870226
73	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.13870226
74	regulation of gamma-delta T cell differentiation (GO:0045586)	3.09409775
75	modulation by symbiont of host cellular process (GO:0044068)	3.08790100
76	leukotriene metabolic process (GO:0006691)	3.07486944
77	unsaturated fatty acid biosynthetic process (GO:0006636)	3.05281588
78	male meiosis (GO:0007140)	3.01147467
79	negative regulation of T cell apoptotic process (GO:0070233)	3.00914547
80	cyclooxygenase pathway (GO:0019371)	2.91983344
81	one-carbon compound transport (GO:0019755)	2.91238396
82	meiotic cell cycle (GO:0051321)	2.87956338
83	multicellular organism reproduction (GO:0032504)	2.87453474
84	regulation of steroid hormone secretion (GO:2000831)	2.85693630
85	meiosis I (GO:0007127)	2.81102550
86	positive regulation of macrophage derived foam cell differentiation (GO:0010744)	2.80051794
87	diacylglycerol metabolic process (GO:0046339)	2.79708005
88	positive regulation of mast cell degranulation (GO:0043306)	2.76963967
89	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.76963967
90	positive regulation of cellular response to insulin stimulus (GO:1900078)	2.76864148
91	arginine metabolic process (GO:0006525)	2.74647237
92	prostaglandin biosynthetic process (GO:0001516)	2.74350215
93	prostanoid biosynthetic process (GO:0046457)	2.74350215
94	regulation of cholesterol metabolic process (GO:0090181)	2.69802893
95	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	2.68700841
96	female gamete generation (GO:0007292)	2.64451568
97	regulation of renal sodium excretion (GO:0035813)	2.62748990
98	synaptonemal complex assembly (GO:0007130)	2.62652697
99	platelet degranulation (GO:0002576)	2.61058374
100	thalamus development (GO:0021794)	10.4233495

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	8.96694879
2	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	4.51896618
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	4.27541107
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.09706008
5	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	3.43983396
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.43067682
7	IRF1_19129219_ChIP-ChIP_H3396_Human	3.23578882
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.15582546
9	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	2.34982923
10	HTT_18923047_ChIP-ChIP_STHdh_Human	1.96850304
11	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.89878319
12	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.80683313
13	IGF1R_20145208_ChIP-Seq_DFB_Human	1.77647387
14	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77209164
15	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.77209164
16	GBX2_23144817_ChIP-Seq_PC3_Human	1.69718148
17	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.67509334
18	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.66986569
19	DROSHA_22980978_ChIP-Seq_HELA_Human	1.66507524
20	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.59943728
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.56937904
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.55341932
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.54872192
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.53018541
25	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.51649866
26	CDX2_22108803_ChIP-Seq_LS180_Human	1.41074276
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.39847239
28	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38423594
29	P300_19829295_ChIP-Seq_ESCs_Human	1.37104552
30	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.37063748
31	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.36898939
32	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.33524580
33	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.32304511
34	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.31786005
35	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.29028403
36	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.27586181
37	LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.25563458
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.25146555
39	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25069375
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25069375
41	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.24831317
42	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.24089277
43	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.22699025
44	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.20364579
45	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20188497
46	RUNX_20019798_ChIP-Seq_JUKART_Human	1.19246755
47	ERG_20517297_ChIP-Seq_VCAP_Human	1.18402188
48	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.18331407
49	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.15260872
50	CEBPB_22108803_ChIP-Seq_LS180_Human	1.15030673
51	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.14502684
52	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13889695
53	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.13114624
54	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12917860
55	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.11158934
56	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.10435380
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.10190763
58	SMAD4_21799915_ChIP-Seq_A2780_Human	1.09432422
59	TAF15_26573619_Chip-Seq_HEK293_Human	1.07422096
60	TP53_16413492_ChIP-PET_HCT116_Human	1.07030902
61	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.06926598
62	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.06880013
63	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.05998269
64	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.05703597
65	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05092246
66	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04471315
67	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.04272125
68	AR_20517297_ChIP-Seq_VCAP_Human	1.03402939
69	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.03170042
70	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02955459
71	EWS_26573619_Chip-Seq_HEK293_Human	1.01457401
72	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01012021
73	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.00504582
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99621516
75	TCF4_22108803_ChIP-Seq_LS180_Human	0.99038414
76	STAT3_23295773_ChIP-Seq_U87_Human	0.98986494
77	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.98120177
78	AR_25329375_ChIP-Seq_VCAP_Human	0.96562202
79	E2F7_22180533_ChIP-Seq_HELA_Human	0.95858096
80	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.93343761
81	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92172098
82	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.91661638
83	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.91309360
84	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.91269533
85	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.90610931
86	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.90498700
87	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.90475397
88	TCF4_23295773_ChIP-Seq_U87_Human	0.90215663
89	VDR_22108803_ChIP-Seq_LS180_Human	0.88324786
90	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.85994397
91	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.85994397
92	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.85994397
93	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.85783778
94	KLF4_19829295_ChIP-Seq_ESCs_Human	0.85703530
95	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.85702146
96	SMRT_27268052_Chip-Seq_Bcells_Human	0.84865785
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.84778827
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.83983964
99	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.83208792
100	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.82868638

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005085_abnormal_gallbladder_physiolo	5.91292888
2	MP0008004_abnormal_stomach_pH	5.87840056
3	MP0003252_abnormal_bile_duct	5.34226569
4	MP0003718_maternal_effect	5.30730406
5	MP0002138_abnormal_hepatobiliary_system	4.98031850
6	MP0005083_abnormal_biliary_tract	4.64550920
7	MP0005464_abnormal_platelet_physiology	4.37137007
8	MP0005365_abnormal_bile_salt	3.22584509
9	MP0009697_abnormal_copulation	3.08232109
10	MP0005645_abnormal_hypothalamus_physiol	2.74502475
11	MP0008877_abnormal_DNA_methylation	2.69817842
12	MP0002736_abnormal_nociception_after	2.58832943
13	MP0003724_increased_susceptibility_to	2.32834746
14	MP0004084_abnormal_cardiac_muscle	2.30041379
15	MP0001664_abnormal_digestion	2.27375422
16	MP0003950_abnormal_plasma_membrane	2.26817541
17	MP0000465_gastrointestinal_hemorrhage	2.23500299
18	MP0003303_peritoneal_inflammation	1.98760144
19	MP0005360_urolithiasis	1.84668345
20	MP0002132_abnormal_respiratory_system	1.79583305
21	MP0008875_abnormal_xenobiotic_pharmacok	1.75838074
22	MP0005395_other_phenotype	1.74572634
23	MP0004142_abnormal_muscle_tone	1.62227946
24	MP0001968_abnormal_touch/_nociception	1.52816452
25	MP0005670_abnormal_white_adipose	1.50945737
26	MP0005410_abnormal_fertilization	1.50668992
27	MP0008569_lethality_at_weaning	1.48938661
28	MP0005257_abnormal_intraocular_pressure	1.45873878
29	MP0008872_abnormal_physiological_respon	1.44444838
30	MP0002139_abnormal_hepatobiliary_system	1.43862456
31	MP0005647_abnormal_sex_gland	1.39631306
32	MP0005075_abnormal_melanosome_morpholog	1.27800097
33	MP0001545_abnormal_hematopoietic_system	1.26359069
34	MP0005397_hematopoietic_system_phenotyp	1.26359069
35	MP0005167_abnormal_blood-brain_barrier	1.18998804
36	MP0002163_abnormal_gland_morphology	1.09040526
37	MP0003186_abnormal_redox_activity	1.08712183
38	MP0001929_abnormal_gametogenesis	1.01905174
39	MP0003959_abnormal_lean_body	0.99663037
40	MP0004858_abnormal_nervous_system	0.99027371
41	MP0005084_abnormal_gallbladder_morpholo	0.98523682
42	MP0003693_abnormal_embryo_hatching	0.95412818
43	MP0002160_abnormal_reproductive_system	0.93586962
44	MP0003698_abnormal_male_reproductive	0.91918176
45	MP0002210_abnormal_sex_determination	0.89869662
46	MP0000653_abnormal_sex_gland	0.89561772
47	MP0000230_abnormal_systemic_arterial	0.87579635
48	MP0002234_abnormal_pharynx_morphology	0.87332223
49	MP0003656_abnormal_erythrocyte_physiolo	0.86942074
50	MP0008874_decreased_physiological_sensi	0.86882919
51	MP0003699_abnormal_female_reproductive	0.84062852
52	MP0003646_muscle_fatigue	0.82681463
53	MP0010094_abnormal_chromosome_stability	0.82085341
54	MP0003136_yellow_coat_color	0.75854010
55	MP0003879_abnormal_hair_cell	0.74487137
56	MP0008932_abnormal_embryonic_tissue	0.74232800
57	MP0001529_abnormal_vocalization	0.74161977
58	MP0002161_abnormal_fertility/fecundity	0.73992753
59	MP0002118_abnormal_lipid_homeostasis	0.72706725
60	MP0001145_abnormal_male_reproductive	0.72211975
61	MP0000427_abnormal_hair_cycle	0.71107674
62	MP0000490_abnormal_crypts_of	0.70389949
63	MP0000015_abnormal_ear_pigmentation	0.69350327
64	MP0008789_abnormal_olfactory_epithelium	0.68420269
65	MP0009053_abnormal_anal_canal	0.68188523
66	MP0009764_decreased_sensitivity_to	0.67794848
67	MP0009765_abnormal_xenobiotic_induced	0.67726586
68	MP0001963_abnormal_hearing_physiology	0.67637817
69	MP0005174_abnormal_tail_pigmentation	0.66168533
70	MP0004145_abnormal_muscle_electrophysio	0.66152679
71	MP0010030_abnormal_orbit_morphology	0.65888636
72	MP0002067_abnormal_sensory_capabilities	0.64919240
73	MP0004036_abnormal_muscle_relaxation	0.64107402
74	MP0002332_abnormal_exercise_endurance	0.62148528
75	MP0005646_abnormal_pituitary_gland	0.62122708
76	MP0000678_abnormal_parathyroid_gland	0.60282572
77	MP0001501_abnormal_sleep_pattern	0.55269755
78	MP0001663_abnormal_digestive_system	0.55100621
79	MP0005636_abnormal_mineral_homeostasis	0.55099749
80	MP0010329_abnormal_lipoprotein_level	0.54621075
81	MP0008057_abnormal_DNA_replication	0.53773954
82	MP0005584_abnormal_enzyme/coenzyme_acti	0.52726335
83	MP0006292_abnormal_olfactory_placode	0.50548898
84	MP0005551_abnormal_eye_electrophysiolog	0.49776063
85	MP0005319_abnormal_enzyme/_coenzyme	0.48897488
86	MP0005394_taste/olfaction_phenotype	0.48804400
87	MP0005499_abnormal_olfactory_system	0.48804400
88	MP0000920_abnormal_myelination	0.47786904
89	MP0009642_abnormal_blood_homeostasis	0.47585783
90	MP0005332_abnormal_amino_acid	0.46877768
91	MP0009643_abnormal_urine_homeostasis	0.46724126
92	MP0001851_eye_inflammation	0.46521132
93	MP0002064_seizures	0.45474029
94	MP0001756_abnormal_urination	0.44889313
95	MP0000026_abnormal_inner_ear	0.44700421
96	MP0006054_spinal_hemorrhage	0.43912167
97	MP0002089_abnormal_postnatal_growth/wei	0.43883757
98	MP0003638_abnormal_response/metabolism_	0.43079874
99	MP0002733_abnormal_thermal_nociception	0.42741892
100	MP0000467_abnormal_esophagus_morphology	0.41797327

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Conjugated hyperbilirubinemia (HP:0002908)	8.18946787
2	Petechiae (HP:0000967)	7.29486086
3	Increased mean platelet volume (HP:0011877)	5.64697978
4	Intrahepatic cholestasis (HP:0001406)	5.58957910
5	Prolonged bleeding time (HP:0003010)	5.52697408
6	Hypophosphatemic rickets (HP:0004912)	5.29345408
7	Abnormal gallbladder physiology (HP:0012438)	5.16692069
8	Cholecystitis (HP:0001082)	5.16692069
9	Abnormal platelet volume (HP:0011876)	5.15008497
10	Impaired platelet aggregation (HP:0003540)	4.70866065
11	Abnormal platelet function (HP:0011869)	4.70866065
12	Menorrhagia (HP:0000132)	4.35086098
13	Gingival bleeding (HP:0000225)	4.27701879
14	Fair hair (HP:0002286)	4.22020814
15	Optic nerve hypoplasia (HP:0000609)	3.97778628
16	Increased density of long bones (HP:0006392)	3.96428110
17	Hematochezia (HP:0002573)	3.92093243
18	Spontaneous hematomas (HP:0007420)	3.89844685
19	Anterior segment dysgenesis (HP:0007700)	3.89841740
20	Abnormality of the labia minora (HP:0012880)	3.89393745
21	Purpura (HP:0000979)	3.85196139
22	Type II lissencephaly (HP:0007260)	3.81703132
23	Epistaxis (HP:0000421)	3.80629687
24	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.55283406
25	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	3.45905920
26	J-shaped sella turcica (HP:0002680)	3.43528961
27	Metaphyseal irregularity (HP:0003025)	3.42688902
28	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	3.29268380
29	Severe visual impairment (HP:0001141)	3.22446150
30	Supernumerary spleens (HP:0009799)	3.17870583
31	Facial hemangioma (HP:0000329)	3.14171630
32	Osteomalacia (HP:0002749)	3.13476467
33	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	3.12229228
34	Retinal dysplasia (HP:0007973)	3.09585346
35	Vacuolated lymphocytes (HP:0001922)	3.07645605
36	Abnormality of lateral ventricle (HP:0030047)	3.05035436
37	Generalized hypopigmentation of hair (HP:0011358)	2.91903878
38	Capillary hemangiomas (HP:0005306)	2.88729559
39	Abnormality of purine metabolism (HP:0004352)	2.81729979
40	Conjunctival telangiectasia (HP:0000524)	2.77581505
41	Tibial bowing (HP:0002982)	2.75872278
42	Short 1st metacarpal (HP:0010034)	2.75320376
43	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.75320376
44	Upper limb muscle weakness (HP:0003484)	2.65494732
45	Abnormal auditory evoked potentials (HP:0006958)	2.62851914
46	Cholelithiasis (HP:0001081)	2.59391736
47	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.55032777
48	Spinal cord compression (HP:0002176)	2.43894034
49	Abnormality of the 1st metacarpal (HP:0010009)	2.41760762
50	Hyperbilirubinemia (HP:0002904)	2.35679895
51	Myoglobinuria (HP:0002913)	2.34437958
52	Fat malabsorption (HP:0002630)	2.33292334
53	Rickets (HP:0002748)	2.30321911
54	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.30315336
55	Abnormal gallbladder morphology (HP:0012437)	2.30127114
56	Abnormality of nucleobase metabolism (HP:0010932)	2.28332175
57	Agitation (HP:0000713)	2.23145731
58	Peripheral hypomyelination (HP:0007182)	2.19655063
59	Short middle phalanx of the 5th finger (HP:0004220)	2.17849364
60	Death in childhood (HP:0003819)	2.15501208
61	Intellectual disability, profound (HP:0002187)	2.14998276
62	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.13643431
63	Abnormal pupillary function (HP:0007686)	2.13514371
64	Abnormal rod and cone electroretinograms (HP:0008323)	2.11222094
65	Poikilocytosis (HP:0004447)	2.06879464
66	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.05834151
67	Elevated alkaline phosphatase (HP:0003155)	2.05377910
68	Reticulocytosis (HP:0001923)	2.00882912
69	Brushfield spots (HP:0001088)	1.99145264
70	Generalized aminoaciduria (HP:0002909)	1.98370269
71	Oligodactyly (hands) (HP:0001180)	1.90310803
72	Pendular nystagmus (HP:0012043)	1.89008335
73	Absent septum pellucidum (HP:0001331)	1.88770437
74	Proximal tubulopathy (HP:0000114)	1.85408397
75	Abnormality of alkaline phosphatase activity (HP:0004379)	1.81683335
76	Conical tooth (HP:0000698)	1.80085829
77	Acanthocytosis (HP:0001927)	1.80021436
78	Cupped ribs (HP:0000887)	1.77562432
79	Inability to walk (HP:0002540)	1.76523752
80	Stenosis of the external auditory canal (HP:0000402)	1.76497742
81	Popliteal pterygium (HP:0009756)	1.75548996
82	Median cleft lip (HP:0000161)	1.73771538
83	Septo-optic dysplasia (HP:0100842)	1.72038009
84	Abnormal enzyme/coenzyme activity (HP:0012379)	1.71034611
85	Abnormality of the septum pellucidum (HP:0007375)	1.69265402
86	Rhabdomyolysis (HP:0003201)	1.68082984
87	Microtia (HP:0008551)	1.66646827
88	Short thumb (HP:0009778)	1.66526765
89	Femoral bowing (HP:0002980)	1.66281607
90	Albinism (HP:0001022)	1.65487120
91	Hepatosplenomegaly (HP:0001433)	1.65411140
92	Abnormality of fatty-acid metabolism (HP:0004359)	1.65292557
93	Split foot (HP:0001839)	1.64962934
94	Gaze-evoked nystagmus (HP:0000640)	1.63611000
95	Bruising susceptibility (HP:0000978)	1.62776514
96	Hypoplastic labia majora (HP:0000059)	1.62234921
97	Palpebral edema (HP:0100540)	1.61471180
98	Abnormality of the gallbladder (HP:0005264)	1.59133799
99	Short phalanx of the thumb (HP:0009660)	1.58939088
100	Attenuation of retinal blood vessels (HP:0007843)	1.58731916

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ARAF	8.76990939
2	MAP3K10	5.42744786
3	PIM2	5.21752147
4	BRAF	4.15205851
5	EIF2AK1	3.98998869
6	LMTK2	3.31595735
7	TEC	2.95317644
8	RAF1	2.84459852
9	BMX	2.20494652
10	ZAK	2.14537786
11	TAOK3	1.90930831
12	GRK5	1.71232800
13	FLT3	1.68818815
14	PRKCI	1.65485969
15	PTK2B	1.52815518
16	TTK	1.45869632
17	MET	1.33687650
18	NEK9	1.26819995
19	TRPM7	1.20738965
20	PKN2	1.20651981
21	PRKG2	1.19107680
22	MOS	1.11164518
23	MST1R	1.10696550
24	KDR	1.09455479
25	EEF2K	1.03780239
26	ADRBK2	1.01782584
27	DMPK	0.96655397
28	PIM1	0.90976307
29	PHKG2	0.85206941
30	PHKG1	0.85206941
31	CSF1R	0.83465043
32	LATS2	0.83290119
33	DDR2	0.80438170
34	NUAK1	0.76412433
35	TNK2	0.71212735
36	PAK1	0.71127487
37	GRK7	0.70499677
38	MAPKAPK3	0.68326729
39	GRK6	0.65769480
40	PRKCE	0.65268311
41	MELK	0.64287173
42	RPS6KA2	0.63579551
43	PLK3	0.62365523
44	MAP3K9	0.59623537
45	ADRBK1	0.59325548
46	CHEK2	0.59193745
47	GRK1	0.58637578
48	CDK9	0.58056372
49	RPS6KA6	0.55321225
50	RPS6KC1	0.54378445
51	RPS6KL1	0.54378445
52	PLK2	0.54309148
53	MAPKAPK5	0.52733184
54	EIF2AK2	0.52297763
55	PKN1	0.52133790
56	AURKA	0.51021485
57	PAK4	0.50642251
58	PLK1	0.50166115
59	FGR	0.47779100
60	TGFBR2	0.46027338
61	PTK2	0.44906388
62	ABL2	0.42895497
63	NME1	0.41520934
64	CAMK2G	0.41109164
65	STK4	0.40596076
66	PRKCQ	0.36697480
67	MAPK10	0.36130772
68	NTRK3	0.36069435
69	RPS6KB2	0.35474875
70	NEK6	0.33212902
71	VRK2	0.32459326
72	DYRK2	0.28983084
73	OXSR1	0.27808782
74	CAMK2A	0.27776381
75	MAPK3	0.27286450
76	PRKACA	0.24575341
77	STK10	0.24201537
78	FRK	0.22519875
79	NLK	0.21355076
80	MST4	0.21112558
81	BRSK2	0.20308977
82	IRAK3	0.19316089
83	BCR	0.18504971
84	PRKACG	0.17685338
85	MAP3K13	0.16938738
86	PRKCG	0.16816475
87	EPHA2	0.16174118
88	PRKG1	0.16100265
89	ERBB2	0.15528192
90	PRKCA	0.14565274
91	EGFR	0.14491354
92	RPS6KA1	0.14465093
93	MAP4K2	0.13271994
94	EIF2AK3	0.12789618
95	STK24	0.11076359
96	CDK19	0.11058005
97	CSNK1E	0.11052115
98	CDK7	0.10910401
99	STK39	0.10308576
100	PRKD1	0.10107373

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	4.52708697
2	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	3.93959305
3	beta-Alanine metabolism_Homo sapiens_hsa00410	3.10780420
4	Long-term depression_Homo sapiens_hsa04730	2.75141891
5	Arginine and proline metabolism_Homo sapiens_hsa00330	2.71287521
6	Platelet activation_Homo sapiens_hsa04611	2.56555513
7	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.52999703
8	ABC transporters_Homo sapiens_hsa02010	2.44825093
9	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	2.27294356
10	Homologous recombination_Homo sapiens_hsa03440	2.18847611
11	Nitrogen metabolism_Homo sapiens_hsa00910	1.82973384
12	Olfactory transduction_Homo sapiens_hsa04740	1.78706750
13	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.66943593
14	Cell cycle_Homo sapiens_hsa04110	1.65975070
15	Basal transcription factors_Homo sapiens_hsa03022	1.63826698
16	Glycerolipid metabolism_Homo sapiens_hsa00561	1.60051899
17	Serotonergic synapse_Homo sapiens_hsa04726	1.59599437
18	Nicotine addiction_Homo sapiens_hsa05033	1.58661493
19	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.56079438
20	Gap junction_Homo sapiens_hsa04540	1.55623189
21	Bile secretion_Homo sapiens_hsa04976	1.53979050
22	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.50629214
23	Phototransduction_Homo sapiens_hsa04744	1.48513330
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.40307248
25	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.38825757
26	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.35059278
27	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.30671100
28	Morphine addiction_Homo sapiens_hsa05032	1.28503170
29	Arginine biosynthesis_Homo sapiens_hsa00220	1.23481249
30	Salivary secretion_Homo sapiens_hsa04970	1.22745621
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.21749837
32	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.21001609
33	Sulfur metabolism_Homo sapiens_hsa00920	1.19488315
34	Butanoate metabolism_Homo sapiens_hsa00650	1.17423690
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.16962474
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.15887770
37	Fatty acid degradation_Homo sapiens_hsa00071	1.12779702
38	ECM-receptor interaction_Homo sapiens_hsa04512	1.12699389
39	Circadian entrainment_Homo sapiens_hsa04713	1.12008003
40	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.07516519
41	Mismatch repair_Homo sapiens_hsa03430	1.00640537
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00599155
43	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.98861283
44	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.97741929
45	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.97324448
46	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.95823589
47	PPAR signaling pathway_Homo sapiens_hsa03320	0.94566801
48	Renin-angiotensin system_Homo sapiens_hsa04614	0.84885318
49	Retinol metabolism_Homo sapiens_hsa00830	0.84595944
50	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.77611264
51	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.76451696
52	Small cell lung cancer_Homo sapiens_hsa05222	0.75906472
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72926401
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71709999
55	Fatty acid elongation_Homo sapiens_hsa00062	0.68955987
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68712217
57	Melanoma_Homo sapiens_hsa05218	0.66705382
58	Alcoholism_Homo sapiens_hsa05034	0.66123420
59	Purine metabolism_Homo sapiens_hsa00230	0.65219193
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.65124950
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65038275
62	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.64002936
63	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.61744914
64	Oocyte meiosis_Homo sapiens_hsa04114	0.61350017
65	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.60120187
66	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.59161265
67	DNA replication_Homo sapiens_hsa03030	0.58999838
68	Notch signaling pathway_Homo sapiens_hsa04330	0.57698778
69	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.56995805
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.56809909
71	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.56544839
72	Circadian rhythm_Homo sapiens_hsa04710	0.55710064
73	Pancreatic cancer_Homo sapiens_hsa05212	0.55682935
74	Asthma_Homo sapiens_hsa05310	0.53768423
75	Sphingolipid metabolism_Homo sapiens_hsa00600	0.52789755
76	Malaria_Homo sapiens_hsa05144	0.50646662
77	Chemokine signaling pathway_Homo sapiens_hsa04062	0.50359281
78	Tryptophan metabolism_Homo sapiens_hsa00380	0.50080134
79	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.49561508
80	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.48208254
81	Cardiac muscle contraction_Homo sapiens_hsa04260	0.47185571
82	Non-small cell lung cancer_Homo sapiens_hsa05223	0.44842943
83	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.43435365
84	GABAergic synapse_Homo sapiens_hsa04727	0.42497276
85	Colorectal cancer_Homo sapiens_hsa05210	0.39615084
86	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.39214262
87	Choline metabolism in cancer_Homo sapiens_hsa05231	0.38758790
88	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.37813254
89	Gastric acid secretion_Homo sapiens_hsa04971	0.37248308
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.35591766
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.35010569
92	Glutathione metabolism_Homo sapiens_hsa00480	0.34811225
93	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.33655807
94	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.33052091
95	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.32708383
96	Renin secretion_Homo sapiens_hsa04924	0.32700515
97	Pentose phosphate pathway_Homo sapiens_hsa00030	0.32519756
98	Viral carcinogenesis_Homo sapiens_hsa05203	0.31211683
99	Endometrial cancer_Homo sapiens_hsa05213	0.29450802
100	Fanconi anemia pathway_Homo sapiens_hsa03460	0.29019524

TAS2R2P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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