TAS2R3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.43413381
2regulation of nucleobase-containing compound transport (GO:0032239)6.01341391
3negative thymic T cell selection (GO:0045060)5.68368303
4positive regulation of gamma-delta T cell activation (GO:0046645)5.59850557
5cell wall macromolecule metabolic process (GO:0044036)5.48869757
6nuclear pore organization (GO:0006999)5.47280698
7negative T cell selection (GO:0043383)5.35323422
8monoubiquitinated protein deubiquitination (GO:0035520)5.24920936
9cytoplasmic mRNA processing body assembly (GO:0033962)5.03047843
10positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.00792643
11regulation of RNA export from nucleus (GO:0046831)4.94408616
12regulation of gamma-delta T cell differentiation (GO:0045586)4.65564298
13positive regulation of alpha-beta T cell proliferation (GO:0046641)4.63447109
14production of molecular mediator involved in inflammatory response (GO:0002532)4.54849323
15positive regulation of viral genome replication (GO:0045070)4.50992990
16pore complex assembly (GO:0046931)4.48692772
17negative regulation of DNA repair (GO:0045738)4.40119978
18G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.38242471
19positive regulation of chemokine secretion (GO:0090197)4.33145798
20glucosamine-containing compound catabolic process (GO:1901072)4.12646209
21DNA duplex unwinding (GO:0032508)4.09369066
22histone mRNA catabolic process (GO:0071044)4.01852280
23histone-serine phosphorylation (GO:0035404)3.98037864
24cellular response to ethanol (GO:0071361)3.97744036
25regulation of translational fidelity (GO:0006450)3.96338249
26DNA geometric change (GO:0032392)3.92641228
27programmed necrotic cell death (GO:0097300)3.83293318
28necrotic cell death (GO:0070265)3.82203898
29regulation of gamma-delta T cell activation (GO:0046643)3.81430653
30cellular response to prostaglandin stimulus (GO:0071379)3.78700394
31N-terminal protein amino acid acetylation (GO:0006474)3.77723930
32regulation of chemokine secretion (GO:0090196)3.73884668
33regulation of alpha-beta T cell proliferation (GO:0046640)3.72809085
34viral mRNA export from host cell nucleus (GO:0046784)3.68782909
35regulation of centriole replication (GO:0046599)3.65927765
36ether lipid metabolic process (GO:0046485)3.61190592
37histone phosphorylation (GO:0016572)3.57292107
38protein K48-linked deubiquitination (GO:0071108)3.55097871
39thymic T cell selection (GO:0045061)3.51889578
40regulation of centrosome duplication (GO:0010824)3.50711889
41regulation of isotype switching to IgG isotypes (GO:0048302)3.46525537
42necroptotic process (GO:0070266)3.40170392
43regulation of NFAT protein import into nucleus (GO:0051532)3.39120749
44positive regulation of DNA-templated transcription, initiation (GO:2000144)3.38694343
45mitotic nuclear envelope disassembly (GO:0007077)3.36757309
46protein K63-linked deubiquitination (GO:0070536)3.34408670
47pericardium development (GO:0060039)3.33879220
48response to prostaglandin E (GO:0034695)3.31317563
49positive regulation of B cell differentiation (GO:0045579)3.31089510
50rRNA catabolic process (GO:0016075)3.25508773
51positive regulation of granulocyte differentiation (GO:0030854)3.23607769
52peptidyl-lysine trimethylation (GO:0018023)3.20624805
53positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.19170340
54nuclear envelope disassembly (GO:0051081)3.18098963
55membrane disassembly (GO:0030397)3.18098963
56replicative senescence (GO:0090399)3.17230038
57pre-miRNA processing (GO:0031054)3.16680600
58regulation of B cell receptor signaling pathway (GO:0050855)3.15975216
59regulation of necroptotic process (GO:0060544)3.15835458
60regulation of interleukin-2 biosynthetic process (GO:0045076)3.14138581
61histone H3-K4 trimethylation (GO:0080182)3.12095423
62positive regulation of natural killer cell mediated immunity (GO:0002717)3.11585495
63positive regulation of developmental pigmentation (GO:0048087)3.10864622
64DNA strand renaturation (GO:0000733)3.10700212
65snRNA transcription (GO:0009301)3.10409949
66positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.03717535
67regulation of centrosome cycle (GO:0046605)3.01725303
68cytokine biosynthetic process (GO:0042089)3.01545617
69positive regulation of protein import into nucleus, translocation (GO:0033160)2.99137151
70phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.98920557
71intra-S DNA damage checkpoint (GO:0031573)2.98617354
72phospholipid translocation (GO:0045332)2.97535783
73lipid translocation (GO:0034204)2.97535783
74inner ear receptor cell differentiation (GO:0060113)2.94027341
75positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.93461252
76peptidyl-lysine dimethylation (GO:0018027)2.92683040
77positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.89502885
78regulation of pigment cell differentiation (GO:0050932)2.89315412
79estrogen biosynthetic process (GO:0006703)2.88902429
80hair cell differentiation (GO:0035315)2.87848563
81nephron epithelium morphogenesis (GO:0072088)2.87641624
82nephron tubule morphogenesis (GO:0072078)2.87641624
83retinal cone cell development (GO:0046549)2.86358553
84base-excision repair, AP site formation (GO:0006285)2.85539350
85interkinetic nuclear migration (GO:0022027)2.83987262
86histone lysine methylation (GO:0034968)2.81104365
87T cell selection (GO:0045058)2.81023612
88positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.79857215
89regulation of protein polyubiquitination (GO:1902914)2.78740971
90histone H3-K9 methylation (GO:0051567)2.77599356
91regulation of energy homeostasis (GO:2000505)2.77158367
92meiotic chromosome segregation (GO:0045132)2.76910883
93nucleotide-excision repair, DNA damage removal (GO:0000718)2.76070683
94DNA excision (GO:0044349)2.76070683
95nuclear envelope organization (GO:0006998)2.75157192
96DNA conformation change (GO:0071103)2.72148526
97C4-dicarboxylate transport (GO:0015740)2.66343285
98N-terminal protein amino acid modification (GO:0031365)2.66017072
99cellular zinc ion homeostasis (GO:0006882)2.65864600
100positive regulation of cellular response to insulin stimulus (GO:1900078)2.65101487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.25795305
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.57021274
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.32445616
4GATA1_22025678_ChIP-Seq_K562_Human4.30394366
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.68441955
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.65018404
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.26188174
8AR_21572438_ChIP-Seq_LNCaP_Human3.22683736
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.13623611
10IGF1R_20145208_ChIP-Seq_DFB_Human3.12435986
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84465270
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.64448479
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.43501529
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29624565
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.29075427
16RUNX_20019798_ChIP-Seq_JUKART_Human2.20938485
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.18265772
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.15394732
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.98985867
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96188116
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93171836
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82699951
23PKCTHETA_26484144_Chip-Seq_BREAST_Human1.69515140
24MYB_26560356_Chip-Seq_TH2_Human1.58164677
25ER_23166858_ChIP-Seq_MCF-7_Human1.54386219
26TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.54153158
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50612706
28CTNNB1_20460455_ChIP-Seq_HCT116_Human1.49183926
29EWS_26573619_Chip-Seq_HEK293_Human1.48178157
30MYB_26560356_Chip-Seq_TH1_Human1.45981000
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.44389699
32FUS_26573619_Chip-Seq_HEK293_Human1.43560706
33TP53_16413492_ChIP-PET_HCT116_Human1.42916748
34GATA3_27048872_Chip-Seq_THYMUS_Human1.37311731
35RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.36599294
36AHR_22903824_ChIP-Seq_MCF-7_Human1.35791847
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32270494
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31878226
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30407293
40SCL_19346495_ChIP-Seq_HPC-7_Human1.29817369
41STAT3_23295773_ChIP-Seq_U87_Human1.29614937
42GATA1_19941826_ChIP-Seq_K562_Human1.29060392
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.22642603
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22463450
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22423825
46MAF_26560356_Chip-Seq_TH1_Human1.20838762
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20089578
48CBP_20019798_ChIP-Seq_JUKART_Human1.20089578
49CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19763897
50FOXA2_19822575_ChIP-Seq_HepG2_Human1.18490026
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18326308
52FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18104356
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.17283463
54ELK1_19687146_ChIP-ChIP_HELA_Human1.13715188
55WDR5_24793694_ChIP-Seq_LNCAP_Human1.13605641
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.12884963
57TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10100973
58SMAD4_21799915_ChIP-Seq_A2780_Human1.09766262
59TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07777266
60PRDM14_20953172_ChIP-Seq_ESCs_Human1.07474496
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06484296
62AR_21909140_ChIP-Seq_LNCAP_Human1.06065699
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05601865
64GATA2_19941826_ChIP-Seq_K562_Human1.05083318
65CIITA_25753668_ChIP-Seq_RAJI_Human1.04982921
66TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04209657
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04043233
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.03339763
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03087433
70GBX2_23144817_ChIP-Seq_PC3_Human1.01817356
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01540159
72MAF_26560356_Chip-Seq_TH2_Human1.00883157
73GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.00834922
74TAF15_26573619_Chip-Seq_HEK293_Human0.99709107
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98692971
76TCF4_23295773_ChIP-Seq_U87_Human0.94312254
77PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93677184
78FLI1_21867929_ChIP-Seq_TH2_Mouse0.88676482
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88559885
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88559885
81PIAS1_25552417_ChIP-Seq_VCAP_Human0.88295986
82PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86254205
83E2F1_21310950_ChIP-Seq_MCF-7_Human0.85371823
84OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84994841
85FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84914194
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.84344879
87SMAD_19615063_ChIP-ChIP_OVARY_Human0.83735940
88KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81069215
89ETV1_20927104_ChIP-Seq_GIST48_Human0.80375888
90VDR_23849224_ChIP-Seq_CD4+_Human0.80178024
91TBL1_22424771_ChIP-Seq_293T_Human0.79449188
92ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79103853
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78396887
94CHD1_26751641_Chip-Seq_LNCaP_Human0.78366338
95MYC_22102868_ChIP-Seq_BL_Human0.78302701
96* GATA3_26560356_Chip-Seq_TH2_Human0.78032727
97SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.76651293
98CBX2_22325352_ChIP-Seq_293T-Rex_Human0.76279839
99SMRT_27268052_Chip-Seq_Bcells_Human0.76159999
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75684571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio5.16085691
2MP0008057_abnormal_DNA_replication4.75673322
3MP0003011_delayed_dark_adaptation3.60654686
4MP0003763_abnormal_thymus_physiology3.54149354
5MP0005174_abnormal_tail_pigmentation3.39283451
6MP0005171_absent_coat_pigmentation3.36858806
7MP0002009_preneoplasia3.25927556
8MP0004381_abnormal_hair_follicle3.19465697
9MP0000569_abnormal_digit_pigmentation3.12113219
10MP0003045_fibrosis2.42172190
11MP0010094_abnormal_chromosome_stability2.37740562
12MP0002277_abnormal_respiratory_mucosa2.23058634
13MP0002095_abnormal_skin_pigmentation2.19489996
14MP0003690_abnormal_glial_cell2.12252891
15MP0003646_muscle_fatigue2.07261642
16MP0004270_analgesia2.02928168
17MP0003136_yellow_coat_color2.02113501
18MP0003111_abnormal_nucleus_morphology1.97633294
19MP0010307_abnormal_tumor_latency1.88497807
20MP0000647_abnormal_sebaceous_gland1.80090852
21MP0005671_abnormal_response_to1.78238478
22MP0003191_abnormal_cellular_cholesterol1.76448856
23MP0005409_darkened_coat_color1.75137589
24MP0010352_gastrointestinal_tract_polyps1.70134682
25MP0001661_extended_life_span1.63460445
26MP0008961_abnormal_basal_metabolism1.59641962
27MP0002396_abnormal_hematopoietic_system1.57903556
28MP0002166_altered_tumor_susceptibility1.55743972
29MP0005423_abnormal_somatic_nervous1.54330438
30MP0000427_abnormal_hair_cycle1.52015547
31MP0003221_abnormal_cardiomyocyte_apopto1.51404558
32MP0005253_abnormal_eye_physiology1.47737968
33MP0001243_abnormal_dermal_layer1.45762301
34MP0001986_abnormal_taste_sensitivity1.44825978
35MP0004130_abnormal_muscle_cell1.41650108
36MP0003195_calcinosis1.33622732
37MP0000604_amyloidosis1.28275981
38MP0002168_other_aberrant_phenotype1.28274594
39MP0003077_abnormal_cell_cycle1.26434505
40MP0002019_abnormal_tumor_incidence1.26051110
41MP0004233_abnormal_muscle_weight1.24147551
42MP0008007_abnormal_cellular_replicative1.23602069
43MP0005551_abnormal_eye_electrophysiolog1.21255227
44MP0005647_abnormal_sex_gland1.20628049
45MP0002638_abnormal_pupillary_reflex1.16756491
46MP0000747_muscle_weakness1.13295924
47MP0000015_abnormal_ear_pigmentation1.12512795
48MP0003091_abnormal_cell_migration1.11210448
49MP0008995_early_reproductive_senescence1.03688835
50MP0002006_tumorigenesis1.02367968
51MP0000703_abnormal_thymus_morphology1.01392168
52MP0005076_abnormal_cell_differentiation0.99718969
53MP0003656_abnormal_erythrocyte_physiolo0.99658982
54MP0003890_abnormal_embryonic-extraembry0.99102228
55MP0003631_nervous_system_phenotype0.96304239
56MP0002075_abnormal_coat/hair_pigmentati0.96037473
57MP0004036_abnormal_muscle_relaxation0.94977741
58MP0004197_abnormal_fetal_growth/weight/0.92682261
59MP0002088_abnormal_embryonic_growth/wei0.91612097
60MP0003633_abnormal_nervous_system0.90830777
61MP0005666_abnormal_adipose_tissue0.89058092
62MP0002398_abnormal_bone_marrow0.87387282
63MP0003632_abnormal_nervous_system0.87324518
64MP0005621_abnormal_cell_physiology0.86200712
65MP0003984_embryonic_growth_retardation0.86104749
66MP0005083_abnormal_biliary_tract0.85528946
67MP0000428_abnormal_craniofacial_morphol0.84818045
68MP0003448_altered_tumor_morphology0.84724965
69MP0004947_skin_inflammation0.84679234
70MP0002971_abnormal_brown_adipose0.81931342
71MP0002060_abnormal_skin_morphology0.81241418
72MP0003705_abnormal_hypodermis_morpholog0.78521217
73MP0008770_decreased_survivor_rate0.76671477
74MP0001191_abnormal_skin_condition0.75178226
75MP0004808_abnormal_hematopoietic_stem0.75021799
76MP0002086_abnormal_extraembryonic_tissu0.74421755
77MP0006054_spinal_hemorrhage0.71690938
78MP0004957_abnormal_blastocyst_morpholog0.69419547
79MP0002722_abnormal_immune_system0.68540355
80MP0000377_abnormal_hair_follicle0.67946228
81MP0005395_other_phenotype0.66100601
82MP0000689_abnormal_spleen_morphology0.66064924
83MP0001186_pigmentation_phenotype0.65850300
84MP0001672_abnormal_embryogenesis/_devel0.65679746
85MP0005380_embryogenesis_phenotype0.65679746
86MP0000350_abnormal_cell_proliferation0.63463668
87MP0001765_abnormal_ion_homeostasis0.63406358
88MP0005391_vision/eye_phenotype0.62247720
89MP0002269_muscular_atrophy0.61462705
90MP0000383_abnormal_hair_follicle0.60541179
91MP0003453_abnormal_keratinocyte_physiol0.59960710
92MP0003786_premature_aging0.59918960
93MP0005448_abnormal_energy_balance0.59229454
94MP0005410_abnormal_fertilization0.58967048
95MP0008058_abnormal_DNA_repair0.57873695
96MP0000538_abnormal_urinary_bladder0.57172119
97MP0000920_abnormal_myelination0.57019560
98MP0002177_abnormal_outer_ear0.56804661
99MP0000716_abnormal_immune_system0.56460066
100MP0001756_abnormal_urination0.56249605

Predicted human phenotypes

RankGene SetZ-score
1Global brain atrophy (HP:0002283)5.53455269
2Poikiloderma (HP:0001029)4.89089540
3Attenuation of retinal blood vessels (HP:0007843)4.78991400
4Chronic hepatic failure (HP:0100626)4.75035673
5Colitis (HP:0002583)4.21976233
6Type 2 muscle fiber atrophy (HP:0003554)4.19633708
7Entropion (HP:0000621)3.85281032
8Anhidrosis (HP:0000970)3.54028968
9Bony spicule pigmentary retinopathy (HP:0007737)3.50815515
10Periodontitis (HP:0000704)3.45765415
11Abnormality of DNA repair (HP:0003254)3.39284060
12Muscle fiber atrophy (HP:0100295)3.36704972
13Fatigable weakness (HP:0003473)3.34220040
14Abnormality of the neuromuscular junction (HP:0003398)3.34220040
15Short chin (HP:0000331)3.19215395
16Malignant hyperthermia (HP:0002047)3.16154640
17Basal cell carcinoma (HP:0002671)3.12390552
18Stomach cancer (HP:0012126)2.90922966
19Chorioretinal atrophy (HP:0000533)2.90200165
20Congenital sensorineural hearing impairment (HP:0008527)2.89088197
21T lymphocytopenia (HP:0005403)2.85817724
22Sandal gap (HP:0001852)2.81887057
23Colon cancer (HP:0003003)2.80026425
24Renovascular hypertension (HP:0100817)2.79266720
25Congenital stationary night blindness (HP:0007642)2.78760987
26Prominent nose (HP:0000448)2.68080509
27Squamous cell carcinoma (HP:0002860)2.61683620
28Easy fatigability (HP:0003388)2.61616970
29Hematochezia (HP:0002573)2.59861313
30Abnormality of T cell number (HP:0011839)2.55863480
31IgA deficiency (HP:0002720)2.51583980
32Inflammation of the large intestine (HP:0002037)2.51253523
33Submucous cleft hard palate (HP:0000176)2.49083121
34Truncal obesity (HP:0001956)2.46282477
35Abnormal pupillary function (HP:0007686)2.45807097
36Short humerus (HP:0005792)2.44698557
37Dysmetric saccades (HP:0000641)2.43882712
38Autoimmune hemolytic anemia (HP:0001890)2.32482363
39Gastrointestinal inflammation (HP:0004386)2.25042657
40IgM deficiency (HP:0002850)2.23081264
41Weak cry (HP:0001612)2.21843376
42Nephroblastoma (Wilms tumor) (HP:0002667)2.16589110
43Abnormality of the nasal septum (HP:0000419)2.15548048
44Hypoplasia of the pons (HP:0012110)2.14128475
45Abnormality of the intrinsic pathway (HP:0010989)2.11405496
46Abnormality of the hepatic vasculature (HP:0006707)2.09478439
47Hemorrhage of the eye (HP:0011885)2.08534171
48Chromsome breakage (HP:0040012)2.08103578
49Aplastic anemia (HP:0001915)2.07620860
50Decreased central vision (HP:0007663)2.07381773
51Abnormality of the fingertips (HP:0001211)2.07016936
52Obsessive-compulsive behavior (HP:0000722)2.06183943
53Aplasia/hypoplasia of the humerus (HP:0006507)2.06151979
54Cutaneous melanoma (HP:0012056)2.06035940
55Decreased lacrimation (HP:0000633)2.05096383
56Capillary hemangiomas (HP:0005306)2.03221634
57Embryonal renal neoplasm (HP:0011794)2.01229276
58Aplasia/Hypoplasia of the earlobes (HP:0009906)2.00570864
59Abnormal spermatogenesis (HP:0008669)2.00023948
60Papillary thyroid carcinoma (HP:0002895)2.00019839
61Abnormality of chromosome stability (HP:0003220)1.99831964
62Febrile seizures (HP:0002373)1.99596609
63Chromosomal breakage induced by crosslinking agents (HP:0003221)1.97512404
64Tubulointerstitial nephritis (HP:0001970)1.96914219
65Hypoplasia of the thymus (HP:0000778)1.96408563
66Alacrima (HP:0000522)1.89819522
67Abnormality of the pons (HP:0007361)1.88662432
68Flat cornea (HP:0007720)1.86072765
69Relative macrocephaly (HP:0004482)1.84727617
70Decreased muscle mass (HP:0003199)1.84691892
71Protruding tongue (HP:0010808)1.83147938
72Intestinal fistula (HP:0100819)1.79660579
73Acute hepatic failure (HP:0006554)1.78667635
74Depressed nasal tip (HP:0000437)1.78403637
75Pancreatic islet-cell hyperplasia (HP:0004510)1.75713403
76Villous atrophy (HP:0011473)1.75290819
77Abnormality of small intestinal villus morphology (HP:0011472)1.75290819
78Thrombocytosis (HP:0001894)1.75289374
7911 pairs of ribs (HP:0000878)1.74572229
80Acute myeloid leukemia (HP:0004808)1.74202814
81Abnormality of alanine metabolism (HP:0010916)1.73843211
82Hyperalaninemia (HP:0003348)1.73843211
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73843211
84Subacute progressive viral hepatitis (HP:0006572)1.73085012
85Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.71071682
86Ectropion (HP:0000656)1.70523216
87Partial agenesis of the corpus callosum (HP:0001338)1.70059270
88Prolonged partial thromboplastin time (HP:0003645)1.70009799
89Neonatal hypoglycemia (HP:0001998)1.67158706
90Acanthocytosis (HP:0001927)1.66667086
91Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.65639439
92Viral hepatitis (HP:0006562)1.65401962
93Supernumerary spleens (HP:0009799)1.63483831
94Poikilocytosis (HP:0004447)1.62088782
95Abnormality of the columella (HP:0009929)1.61766947
96Overlapping toe (HP:0001845)1.61413477
97Azoospermia (HP:0000027)1.60057841
98Neoplasm of the liver (HP:0002896)1.59158391
99Portal hypertension (HP:0001409)1.59135068
100Birth length less than 3rd percentile (HP:0003561)1.58541699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK9.67130937
2TESK26.54296753
3RIPK14.83795999
4MAP3K103.08512240
5ACVR1B2.13960309
6TXK1.77577680
7IKBKE1.74589575
8BRD41.64236746
9BRSK21.63088474
10FRK1.61581429
11PDGFRB1.49521339
12CDK121.47676422
13CAMKK21.47406637
14NLK1.36865425
15AKT31.28683191
16ITK1.26254068
17BLK1.16874007
18TYK21.15998916
19TRIB31.14668769
20NEK61.13811336
21PASK1.08362439
22WNK10.99814744
23CAMKK10.99033281
24SGK20.98251746
25CDK80.92565232
26CAMK1D0.90839922
27PDK20.90752673
28ATR0.87155736
29JAK10.85878314
30LATS10.85420189
31MELK0.82065755
32ZAK0.78743860
33PRKCH0.78548102
34IRAK20.78159757
35WNK40.77078566
36SGK30.73778500
37PIK3CA0.72341871
38NEK90.72070649
39PDGFRA0.71709142
40TTK0.69999511
41TRPM70.69193019
42CAMK1G0.64845292
43EEF2K0.64724823
44FGFR30.64580135
45OBSCN0.64212522
46NTRK30.59529128
47CSK0.59374770
48CDC70.59109008
49JAK20.58863815
50SGK2230.55951943
51SGK4940.55951943
52TBK10.55044934
53MKNK20.54746414
54MARK20.53839354
55MTOR0.53298684
56TLK10.52121905
57IRAK40.51775167
58LCK0.51376149
59MAP3K70.50274350
60PIM10.50149706
61ATM0.49704773
62BMPR1B0.49455536
63BTK0.48588319
64TEC0.48432809
65ERBB20.48360669
66FGFR20.47307739
67STK38L0.45126953
68SGK10.43093684
69RIPK40.41308778
70PDK10.40394930
71RAF10.40386408
72CHEK20.39713018
73TYRO30.39502379
74MAPK110.39052363
75ZAP700.38055135
76RPS6KB20.37843362
77MAP2K60.37468558
78IRAK10.37058804
79MKNK10.36559045
80SYK0.36373850
81PRKAA20.36342312
82DYRK1B0.35135284
83MAP3K20.34687136
84CDK60.34652547
85ALK0.34241169
86ICK0.33975223
87MAP3K130.33612349
88MAPK150.32459860
89STK30.31934043
90CHEK10.29104666
91STK240.28098071
92RPS6KB10.25584731
93EPHA40.24736897
94TAF10.24322221
95CDC42BPA0.24205678
96CDK10.24022029
97MST1R0.23637614
98PDPK10.23557729
99FGFR10.22318685
100MAPK80.21781713

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.21678642
2Lysine degradation_Homo sapiens_hsa003102.21555962
3RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.17768026
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.14309655
5Fanconi anemia pathway_Homo sapiens_hsa034602.06573737
6Systemic lupus erythematosus_Homo sapiens_hsa053222.02610216
7Fatty acid biosynthesis_Homo sapiens_hsa000611.81058289
8Phosphatidylinositol signaling system_Homo sapiens_hsa040701.75032884
9Non-homologous end-joining_Homo sapiens_hsa034501.72152426
10Non-small cell lung cancer_Homo sapiens_hsa052231.69407084
11Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.68076256
12Cell cycle_Homo sapiens_hsa041101.67010440
13One carbon pool by folate_Homo sapiens_hsa006701.61215521
14Nucleotide excision repair_Homo sapiens_hsa034201.59846030
15ABC transporters_Homo sapiens_hsa020101.57394517
16Basal transcription factors_Homo sapiens_hsa030221.55994226
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.48702537
18T cell receptor signaling pathway_Homo sapiens_hsa046601.45948326
19Thyroid cancer_Homo sapiens_hsa052161.43701073
20Chronic myeloid leukemia_Homo sapiens_hsa052201.41270743
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32409448
22Platelet activation_Homo sapiens_hsa046111.32262383
23Measles_Homo sapiens_hsa051621.31775938
24Inositol phosphate metabolism_Homo sapiens_hsa005621.28811352
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.28412524
26Choline metabolism in cancer_Homo sapiens_hsa052311.28331031
27Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26977404
28Alcoholism_Homo sapiens_hsa050341.22848857
29MicroRNAs in cancer_Homo sapiens_hsa052061.22325808
30FoxO signaling pathway_Homo sapiens_hsa040681.22261761
31Viral carcinogenesis_Homo sapiens_hsa052031.20759411
32RNA degradation_Homo sapiens_hsa030181.17252242
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12561512
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.10338245
35Endometrial cancer_Homo sapiens_hsa052131.09477987
36ErbB signaling pathway_Homo sapiens_hsa040121.08626065
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06980193
38Acute myeloid leukemia_Homo sapiens_hsa052211.06237822
39Small cell lung cancer_Homo sapiens_hsa052220.99896012
40RNA transport_Homo sapiens_hsa030130.98385504
41p53 signaling pathway_Homo sapiens_hsa041150.98383668
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98166405
43Hedgehog signaling pathway_Homo sapiens_hsa043400.97884487
44Homologous recombination_Homo sapiens_hsa034400.96849278
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96547793
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.95921060
47mTOR signaling pathway_Homo sapiens_hsa041500.94590332
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.93890560
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93844002
50Circadian rhythm_Homo sapiens_hsa047100.93459059
51Renal cell carcinoma_Homo sapiens_hsa052110.92525206
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92328294
53Pancreatic cancer_Homo sapiens_hsa052120.88471400
54Renin secretion_Homo sapiens_hsa049240.88376242
55Ovarian steroidogenesis_Homo sapiens_hsa049130.87984670
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87359726
57Hepatitis C_Homo sapiens_hsa051600.86519457
58* Taste transduction_Homo sapiens_hsa047420.86500178
59Prolactin signaling pathway_Homo sapiens_hsa049170.86294266
60Prostate cancer_Homo sapiens_hsa052150.85382651
61B cell receptor signaling pathway_Homo sapiens_hsa046620.83278129
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82378737
63Glioma_Homo sapiens_hsa052140.82313482
64Nitrogen metabolism_Homo sapiens_hsa009100.81491353
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79827733
66Olfactory transduction_Homo sapiens_hsa047400.78064927
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77056674
68Type II diabetes mellitus_Homo sapiens_hsa049300.76703226
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74512417
70Colorectal cancer_Homo sapiens_hsa052100.73843200
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.73492994
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72775767
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71044944
74mRNA surveillance pathway_Homo sapiens_hsa030150.70022446
75VEGF signaling pathway_Homo sapiens_hsa043700.68864841
76Glycerolipid metabolism_Homo sapiens_hsa005610.67781321
77Pathways in cancer_Homo sapiens_hsa052000.67757759
78Adherens junction_Homo sapiens_hsa045200.67606808
79Glutamatergic synapse_Homo sapiens_hsa047240.65063560
80HTLV-I infection_Homo sapiens_hsa051660.64752253
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63580831
82Basal cell carcinoma_Homo sapiens_hsa052170.61590077
83Dorso-ventral axis formation_Homo sapiens_hsa043200.59990086
84Hepatitis B_Homo sapiens_hsa051610.58148987
85Proteoglycans in cancer_Homo sapiens_hsa052050.57203328
86Malaria_Homo sapiens_hsa051440.56748387
87TGF-beta signaling pathway_Homo sapiens_hsa043500.56661655
88Focal adhesion_Homo sapiens_hsa045100.56449273
89Calcium signaling pathway_Homo sapiens_hsa040200.56088690
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.55663799
91Nicotine addiction_Homo sapiens_hsa050330.55317701
92Vitamin digestion and absorption_Homo sapiens_hsa049770.54811812
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.53604162
94Hematopoietic cell lineage_Homo sapiens_hsa046400.52491085
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51863357
96Linoleic acid metabolism_Homo sapiens_hsa005910.51808555
97GnRH signaling pathway_Homo sapiens_hsa049120.51646408
98Insulin resistance_Homo sapiens_hsa049310.49794238
99Apoptosis_Homo sapiens_hsa042100.47788505
100Renin-angiotensin system_Homo sapiens_hsa046140.46961209

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