TAS2R31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TAS2R44 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)7.07420618
2* detection of chemical stimulus involved in sensory perception of taste (GO:0050912)5.76979031
3acrosome assembly (GO:0001675)5.39348021
4ether lipid metabolic process (GO:0046485)4.75229106
5nuclear pore complex assembly (GO:0051292)4.72758191
6nuclear pore organization (GO:0006999)4.70827832
7ribonucleoprotein complex disassembly (GO:0032988)4.31575257
8protein prenylation (GO:0018342)4.30391810
9prenylation (GO:0097354)4.30391810
10branching involved in prostate gland morphogenesis (GO:0060442)4.23382884
11inositol metabolic process (GO:0006020)4.17706087
12positive regulation of developmental pigmentation (GO:0048087)4.13497095
13pre-miRNA processing (GO:0031054)3.92110236
14microtubule anchoring (GO:0034453)3.87882885
15positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.86212238
16regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.86212238
17organelle disassembly (GO:1903008)3.85235780
18negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.84296420
19negative regulation of translation, ncRNA-mediated (GO:0040033)3.84296420
20regulation of translation, ncRNA-mediated (GO:0045974)3.84296420
21regulation of mesenchymal cell apoptotic process (GO:2001053)3.81037551
22negative regulation of T-helper cell differentiation (GO:0045623)3.77069703
23negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.77069703
24spermatid nucleus differentiation (GO:0007289)3.60549323
25DNA integration (GO:0015074)3.59988903
26monoubiquitinated protein deubiquitination (GO:0035520)3.56834411
27regulation of mitotic spindle checkpoint (GO:1903504)3.56523089
28regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.56523089
29regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.56215047
30positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.56215047
31rRNA catabolic process (GO:0016075)3.55411147
32neural tube formation (GO:0001841)3.44136633
33pore complex assembly (GO:0046931)3.38782588
34positive regulation of cell cycle checkpoint (GO:1901978)3.37404242
35interkinetic nuclear migration (GO:0022027)3.30079136
36negative regulation of DNA repair (GO:0045738)3.27518115
37cytoplasmic mRNA processing body assembly (GO:0033962)3.18346251
38head development (GO:0060322)3.15802702
39regulation of DNA endoreduplication (GO:0032875)3.15450705
40male genitalia development (GO:0030539)3.12750086
41positive regulation of mRNA processing (GO:0050685)3.12673632
42positive regulation of mRNA 3-end processing (GO:0031442)3.12518123
43regulation of pigment cell differentiation (GO:0050932)3.10180641
44platelet dense granule organization (GO:0060155)3.09632894
45negative regulation of alpha-beta T cell differentiation (GO:0046639)3.08955654
46establishment of protein localization to Golgi (GO:0072600)3.07181815
47nucleus localization (GO:0051647)3.07161538
48establishment of nucleus localization (GO:0040023)3.07109838
49negative regulation of translational initiation (GO:0045947)3.04477304
50regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.04358844
51regulation of centriole replication (GO:0046599)3.01716341
52positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.01608971
53retinal ganglion cell axon guidance (GO:0031290)3.01468846
54histone mRNA catabolic process (GO:0071044)3.01090696
55positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.00981707
56regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.00981707
57protein localization to cilium (GO:0061512)2.99976713
58intra-Golgi vesicle-mediated transport (GO:0006891)2.99326262
59retrograde transport, vesicle recycling within Golgi (GO:0000301)2.94747196
60regulation of mRNA catabolic process (GO:0061013)2.94170977
61mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.93853297
62positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.93853297
63histone H3-K4 trimethylation (GO:0080182)2.93194877
64lateral ventricle development (GO:0021670)2.91015090
65sister chromatid cohesion (GO:0007062)2.88700516
66positive regulation of mRNA catabolic process (GO:0061014)2.88555280
67negative regulation of fibroblast apoptotic process (GO:2000270)2.85662666
68protein targeting to Golgi (GO:0000042)2.80529062
69positive regulation of mRNA metabolic process (GO:1903313)2.80337830
70ncRNA catabolic process (GO:0034661)2.78107320
71dosage compensation (GO:0007549)2.77145938
72imidazole-containing compound metabolic process (GO:0052803)2.75606054
73retinal cone cell development (GO:0046549)2.75373033
74regulation of mRNA 3-end processing (GO:0031440)2.74694827
75phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.73486391
76glycerol ether metabolic process (GO:0006662)2.73130342
77regulation of T-helper 1 cell differentiation (GO:0045625)2.70067939
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.68255237
79RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66879900
80reproductive system development (GO:0061458)2.66672192
81positive regulation of erythrocyte differentiation (GO:0045648)2.64526825
82resolution of meiotic recombination intermediates (GO:0000712)2.63659156
83auditory receptor cell stereocilium organization (GO:0060088)2.62200139
84prostate gland epithelium morphogenesis (GO:0060740)2.61026506
85snRNA transcription (GO:0009301)2.59695097
86synapsis (GO:0007129)2.59623811
87regulation of glutamate secretion (GO:0014048)2.58598276
88protein localization to Golgi apparatus (GO:0034067)2.57054737
89somite rostral/caudal axis specification (GO:0032525)2.56034832
90myelin assembly (GO:0032288)2.54628309
91intraciliary transport (GO:0042073)2.54488154
92non-recombinational repair (GO:0000726)2.52542023
93double-strand break repair via nonhomologous end joining (GO:0006303)2.52542023
94regulation of Golgi to plasma membrane protein transport (GO:0042996)2.49659354
95* detection of chemical stimulus involved in sensory perception (GO:0050907)2.48878141
96histone H3-K4 methylation (GO:0051568)2.48707503
97regulation of DNA damage checkpoint (GO:2000001)2.48551647
98positive regulation of amino acid transport (GO:0051957)2.48243884
99regulation of centrosome duplication (GO:0010824)2.48217910
100hindbrain development (GO:0030902)2.47088611

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1POU3F2_20337985_ChIP-ChIP_501MEL_Human3.50066002
2FUS_26573619_Chip-Seq_HEK293_Human3.45223955
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.04221064
4EWS_26573619_Chip-Seq_HEK293_Human2.81408144
5TAF15_26573619_Chip-Seq_HEK293_Human2.72818076
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58211047
7GBX2_23144817_ChIP-Seq_PC3_Human2.55561215
8ZNF274_21170338_ChIP-Seq_K562_Hela2.53843220
9ELK1_19687146_ChIP-ChIP_HELA_Human2.43625368
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.41863393
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40955097
12P300_19829295_ChIP-Seq_ESCs_Human2.32982221
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.31661057
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.25423375
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.24141643
16GATA1_22025678_ChIP-Seq_K562_Human2.17981576
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.16099744
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04492789
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98742392
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95189887
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93707918
22SMAD4_21799915_ChIP-Seq_A2780_Human1.84922495
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83146907
24PADI4_21655091_ChIP-ChIP_MCF-7_Human1.76562815
25ER_23166858_ChIP-Seq_MCF-7_Human1.74897528
26CBP_20019798_ChIP-Seq_JUKART_Human1.69315703
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.69315703
28IGF1R_20145208_ChIP-Seq_DFB_Human1.69282470
29STAT3_23295773_ChIP-Seq_U87_Human1.68572536
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67736596
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65662800
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63353108
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60229130
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.60033751
35TCF4_23295773_ChIP-Seq_U87_Human1.59025263
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.56833446
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.54748840
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52366864
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50453122
40TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.49169478
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48801629
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.48424901
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48388358
44VDR_22108803_ChIP-Seq_LS180_Human1.47350900
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46511691
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43120413
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42160270
48VDR_23849224_ChIP-Seq_CD4+_Human1.39677266
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39607282
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.38809580
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38474007
52RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.37650895
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37635092
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37556147
55RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36858297
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.35817768
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35273639
58RNF2_27304074_Chip-Seq_NSC_Mouse1.35085936
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.34337923
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.32310357
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31813075
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29459814
63TP53_22573176_ChIP-Seq_HFKS_Human1.29032039
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27992825
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27013244
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.26891537
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26602438
68AR_25329375_ChIP-Seq_VCAP_Human1.25959283
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.25085739
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23920864
71MYC_18940864_ChIP-ChIP_HL60_Human1.23566396
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22878847
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22396340
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.22250184
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21567685
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.21317767
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19832109
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19832109
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19570404
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18198504
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16811606
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.16200035
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15692708
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15398377
85CDX2_22108803_ChIP-Seq_LS180_Human1.13831989
86BCAT_22108803_ChIP-Seq_LS180_Human1.10161908
87FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.08620216
88TCF4_22108803_ChIP-Seq_LS180_Human1.08424205
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08318539
90RUNX2_22187159_ChIP-Seq_PCA_Human1.07783785
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07103998
92JUN_21703547_ChIP-Seq_K562_Human1.04292419
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03843772
94FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03593855
95CRX_20693478_ChIP-Seq_RETINA_Mouse1.01883270
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.01595236
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.01488892
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.00828399
99SALL4_22934838_ChIP-ChIP_CD34+_Human0.99184912
100CMYC_18555785_Chip-Seq_ESCs_Mouse0.97414528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.01628492
2MP0000516_abnormal_urinary_system4.47946218
3MP0005367_renal/urinary_system_phenotyp4.47946218
4MP0005187_abnormal_penis_morphology4.09678564
5MP0000537_abnormal_urethra_morphology4.08998227
6MP0006054_spinal_hemorrhage3.06321991
7MP0008057_abnormal_DNA_replication2.89215570
8MP0008877_abnormal_DNA_methylation2.67573898
9MP0003315_abnormal_perineum_morphology2.57674550
10MP0003937_abnormal_limbs/digits/tail_de2.43333037
11MP0003890_abnormal_embryonic-extraembry2.24510263
12MP0008007_abnormal_cellular_replicative2.23688252
13MP0008058_abnormal_DNA_repair2.06212078
14MP0005645_abnormal_hypothalamus_physiol2.03314634
15MP0003880_abnormal_central_pattern1.75630943
16MP0009697_abnormal_copulation1.69275154
17MP0005083_abnormal_biliary_tract1.60926613
18MP0005253_abnormal_eye_physiology1.55632318
19MP0002751_abnormal_autonomic_nervous1.54845279
20MP0005248_abnormal_Harderian_gland1.51524437
21MP0002009_preneoplasia1.50841539
22MP0003121_genomic_imprinting1.48444864
23MP0003787_abnormal_imprinting1.47040086
24MP0003656_abnormal_erythrocyte_physiolo1.47006892
25MP0000383_abnormal_hair_follicle1.43936313
26MP0003122_maternal_imprinting1.42632750
27MP0006276_abnormal_autonomic_nervous1.41205923
28MP0001984_abnormal_olfaction1.37673465
29MP0003136_yellow_coat_color1.37104292
30MP0004147_increased_porphyrin_level1.34389063
31MP0008995_early_reproductive_senescence1.34368793
32MP0006072_abnormal_retinal_apoptosis1.33298162
33MP0002638_abnormal_pupillary_reflex1.27787894
34MP0001968_abnormal_touch/_nociception1.27442154
35MP0002938_white_spotting1.21950946
36MP0003221_abnormal_cardiomyocyte_apopto1.21139606
37MP0004808_abnormal_hematopoietic_stem1.19194768
38MP0003077_abnormal_cell_cycle1.18803996
39MP0001293_anophthalmia1.17610256
40MP0001286_abnormal_eye_development1.17511375
41MP0002837_dystrophic_cardiac_calcinosis1.15592165
42MP0002396_abnormal_hematopoietic_system1.12239912
43MP0000372_irregular_coat_pigmentation1.11509307
44MP0010094_abnormal_chromosome_stability1.08741079
45MP0002095_abnormal_skin_pigmentation1.08002340
46MP0002697_abnormal_eye_size1.06024180
47MP0002139_abnormal_hepatobiliary_system1.05842593
48MP0003786_premature_aging1.04951995
49MP0002282_abnormal_trachea_morphology1.04549448
50MP0002127_abnormal_cardiovascular_syste1.04040503
51MP0002138_abnormal_hepatobiliary_system1.03979995
52MP0000631_abnormal_neuroendocrine_gland1.02085512
53MP0005174_abnormal_tail_pigmentation1.01828417
54MP0005391_vision/eye_phenotype1.00327405
55MP0010678_abnormal_skin_adnexa0.98671266
56MP0000015_abnormal_ear_pigmentation0.95701188
57MP0001324_abnormal_eye_pigmentation0.95029819
58MP0002233_abnormal_nose_morphology0.94480267
59MP0001145_abnormal_male_reproductive0.92458067
60MP0001915_intracranial_hemorrhage0.92413511
61MP0002736_abnormal_nociception_after0.91279391
62MP0005379_endocrine/exocrine_gland_phen0.90924284
63MP0001929_abnormal_gametogenesis0.87836591
64MP0005075_abnormal_melanosome_morpholog0.87294785
65MP0000427_abnormal_hair_cycle0.87007538
66MP0005423_abnormal_somatic_nervous0.86091448
67MP0002109_abnormal_limb_morphology0.85882078
68MP0003698_abnormal_male_reproductive0.84670802
69MP0002210_abnormal_sex_determination0.84274317
70MP0000647_abnormal_sebaceous_gland0.84245656
71MP0005197_abnormal_uvea_morphology0.83756850
72MP0001919_abnormal_reproductive_system0.82097655
73MP0003935_abnormal_craniofacial_develop0.81892539
74MP0000538_abnormal_urinary_bladder0.80964090
75MP0005551_abnormal_eye_electrophysiolog0.80734402
76MP0002184_abnormal_innervation0.79592201
77MP0000653_abnormal_sex_gland0.79038043
78MP0001502_abnormal_circadian_rhythm0.76193734
79MP0004145_abnormal_muscle_electrophysio0.75649180
80MP0009703_decreased_birth_body0.75474808
81MP0003111_abnormal_nucleus_morphology0.74620242
82MP0003942_abnormal_urinary_system0.74537790
83MP0003252_abnormal_bile_duct0.73047586
84MP0000778_abnormal_nervous_system0.72830760
85MP0002102_abnormal_ear_morphology0.72410278
86MP0002092_abnormal_eye_morphology0.71195820
87MP0004381_abnormal_hair_follicle0.70989816
88MP0002234_abnormal_pharynx_morphology0.69942927
89MP0005646_abnormal_pituitary_gland0.69731160
90MP0001879_abnormal_lymphatic_vessel0.69530747
91MP0001119_abnormal_female_reproductive0.69409015
92MP0001672_abnormal_embryogenesis/_devel0.68652531
93MP0005380_embryogenesis_phenotype0.68652531
94MP0005389_reproductive_system_phenotype0.68453012
95MP0003183_abnormal_peptide_metabolism0.68074619
96MP0005085_abnormal_gallbladder_physiolo0.67687548
97MP0000955_abnormal_spinal_cord0.67538530
98MP0002160_abnormal_reproductive_system0.67434229
99MP0004197_abnormal_fetal_growth/weight/0.67092747
100MP0008961_abnormal_basal_metabolism0.67061847

Predicted human phenotypes

RankGene SetZ-score
1Short 1st metacarpal (HP:0010034)4.08898061
2Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.08898061
3Medulloblastoma (HP:0002885)3.99426994
4Abnormality of the 1st metacarpal (HP:0010009)3.55828912
5Septate vagina (HP:0001153)3.38686597
6Abnormality of the astrocytes (HP:0100707)3.33556201
7Astrocytoma (HP:0009592)3.33556201
8Aplasia/Hypoplasia of the tibia (HP:0005772)3.30686204
9Papillary thyroid carcinoma (HP:0002895)3.19454258
10Colon cancer (HP:0003003)3.17764415
11Abnormality of the 2nd finger (HP:0004100)3.10684407
123-Methylglutaconic aciduria (HP:0003535)3.02771231
13Short tibia (HP:0005736)3.00457577
14Aplasia/hypoplasia of the humerus (HP:0006507)2.88995405
15Short phalanx of the thumb (HP:0009660)2.87810457
16Short 5th finger (HP:0009237)2.86446382
17Abnormality of midbrain morphology (HP:0002418)2.83952020
18Molar tooth sign on MRI (HP:0002419)2.83952020
19Abnormal tarsal ossification (HP:0008369)2.81813282
20Ependymoma (HP:0002888)2.75928138
21Chronic hepatic failure (HP:0100626)2.71483206
22Failure to thrive in infancy (HP:0001531)2.69501219
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.62272981
24Meckel diverticulum (HP:0002245)2.61654736
25Glioma (HP:0009733)2.60232196
26Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.58044746
27Abnormality of chromosome stability (HP:0003220)2.57577254
28Abnormality of the ileum (HP:0001549)2.49967560
29Bile duct proliferation (HP:0001408)2.46977795
30Abnormal biliary tract physiology (HP:0012439)2.46977795
31Short humerus (HP:0005792)2.43628003
32Abnormal foot bone ossification (HP:0010675)2.43448831
33Impaired vibration sensation in the lower limbs (HP:0002166)2.42323447
34Cerebellar dysplasia (HP:0007033)2.38978787
35Volvulus (HP:0002580)2.38956184
36Hypoplastic pelvis (HP:0008839)2.34599233
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.33015566
38Septo-optic dysplasia (HP:0100842)2.30711725
39Congenital primary aphakia (HP:0007707)2.29142236
40Fibular hypoplasia (HP:0003038)2.27508753
41Pancreatic cysts (HP:0001737)2.26728412
42Hyperventilation (HP:0002883)2.24394125
43Proximal tubulopathy (HP:0000114)2.21475973
44Spontaneous abortion (HP:0005268)2.21293474
45Thyroid carcinoma (HP:0002890)2.20930593
46Nephrogenic diabetes insipidus (HP:0009806)2.19166085
47Nephroblastoma (Wilms tumor) (HP:0002667)2.17632520
48Poor coordination (HP:0002370)2.17371483
49Gait imbalance (HP:0002141)2.17026774
50Chromsome breakage (HP:0040012)2.14633392
51Aplasia/Hypoplasia of the fibula (HP:0006492)2.11846932
52Fibular aplasia (HP:0002990)2.10295784
53Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.07897517
54Abnormality of the carotid arteries (HP:0005344)2.05839613
55Medial flaring of the eyebrow (HP:0010747)2.04886365
56Embryonal renal neoplasm (HP:0011794)2.03066763
57Entropion (HP:0000621)2.02885567
58Synostosis of carpal bones (HP:0005048)1.99293958
59Subacute progressive viral hepatitis (HP:0006572)1.98090978
60Short hallux (HP:0010109)1.97522763
61Gaze-evoked nystagmus (HP:0000640)1.97191737
62Vaginal atresia (HP:0000148)1.96837554
63Abnormality of chromosome segregation (HP:0002916)1.96745437
64Degeneration of the lateral corticospinal tracts (HP:0002314)1.96607537
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96607537
66Bifid tongue (HP:0010297)1.96194887
67Attenuation of retinal blood vessels (HP:0007843)1.95161284
68Large earlobe (HP:0009748)1.92702629
69Broad nasal tip (HP:0000455)1.91577113
70Postaxial hand polydactyly (HP:0001162)1.91142239
71Unilateral renal agenesis (HP:0000122)1.90945234
72Decreased testicular size (HP:0008734)1.90888746
73Neoplasm of the oral cavity (HP:0100649)1.88513547
74Genital tract atresia (HP:0001827)1.87823851
75Abnormality of the preputium (HP:0100587)1.87101949
76Genetic anticipation (HP:0003743)1.86480356
77Aplasia/Hypoplasia of the hallux (HP:0008362)1.84819360
78Duodenal stenosis (HP:0100867)1.83742733
79Small intestinal stenosis (HP:0012848)1.83742733
80Short foot (HP:0001773)1.83713667
81Rhabdomyosarcoma (HP:0002859)1.83590899
82Small hand (HP:0200055)1.83415190
83Clubbing of toes (HP:0100760)1.82383085
84Astigmatism (HP:0000483)1.80400301
85Absent eyebrow (HP:0002223)1.78797182
86Short thumb (HP:0009778)1.74551442
87Renal hypoplasia (HP:0000089)1.74011256
88Short middle phalanx of finger (HP:0005819)1.72483944
89Abnormality of the septum pellucidum (HP:0007375)1.71634164
90Carpal synostosis (HP:0009702)1.71079665
91Nephronophthisis (HP:0000090)1.70633161
92Impaired vibratory sensation (HP:0002495)1.70098410
93Chronic sinusitis (HP:0011109)1.69637793
94Cupped ear (HP:0000378)1.69097330
95Micronodular cirrhosis (HP:0001413)1.67570100
96Ureteral obstruction (HP:0006000)1.67420223
97Hypopigmentation of the fundus (HP:0007894)1.66095176
98Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65686126
99Abnormality of the renal medulla (HP:0100957)1.64992577
100Neoplasm of striated muscle (HP:0009728)1.63536930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK14.60034150
2MAP3K43.68886967
3PLK22.97379850
4FRK2.94428786
5BRD42.89283753
6FLT32.84472031
7MAP2K72.67951366
8EIF2AK12.58471262
9NUAK12.45716103
10ERBB32.41646616
11WNK32.23844625
12MAP2K42.18735072
13MAP4K22.06542277
14BCR1.96193064
15AKT31.89778707
16MAP3K61.79304002
17EIF2AK31.72075247
18CSNK1A1L1.66163502
19CSNK1G31.63017959
20CSNK1G11.62508008
21PKN21.56936427
22ERBB41.53980887
23MAPK131.42465501
24CSNK1G21.42461852
25BMPR1B1.38749200
26ZAK1.27899754
27STK38L1.20733749
28TLK11.19000796
29OBSCN1.18873461
30TEC1.07894209
31FGFR31.02949429
32TAOK31.02152250
33BMPR20.98199167
34ACVR1B0.95104497
35DYRK1A0.93605738
36CAMKK20.92019927
37FER0.90271262
38CDK60.88826655
39ATR0.88140375
40STK390.87990929
41RPS6KB10.87384312
42PAK30.83711264
43ATM0.82767189
44CASK0.82286357
45MKNK10.82047634
46MKNK20.81838471
47TNIK0.81688415
48VRK10.80080642
49TSSK60.78617979
50PRKCE0.77775828
51OXSR10.76769885
52RPS6KA40.76641379
53RPS6KA50.73964220
54ERBB20.72923582
55MARK10.68981600
56PDGFRB0.66928049
57PLK30.65789178
58SGK20.65573459
59MAP3K50.63234353
60PLK10.57971495
61CSNK1D0.56611540
62EGFR0.55465540
63BRSK20.55071171
64FGR0.54871345
65SGK10.54808122
66INSRR0.49784433
67CHUK0.48561929
68RET0.47865533
69TGFBR10.46464183
70FGFR10.45575976
71ADRBK20.45101540
72PRKACB0.43167597
73DYRK20.42221516
74BTK0.40783037
75MET0.39516017
76KIT0.39067157
77CSNK1E0.37827576
78TAF10.37801161
79CAMK1D0.37035535
80PNCK0.36612769
81CAMK1G0.36602710
82SGK4940.36202515
83SGK2230.36202515
84CDK190.35735382
85CDK10.34766806
86CDK20.34056722
87CSNK1A10.32507338
88STK40.32477923
89RPS6KB20.32435190
90CHEK10.32365298
91AURKB0.31844554
92GSK3B0.28376791
93SYK0.28357428
94DYRK30.27965120
95PRKG10.27957608
96PTK2B0.27338417
97CSF1R0.27000606
98PIM10.26934266
99AKT20.26418635
100PIK3CA0.26294009

Predicted pathways (KEGG)

RankGene SetZ-score
1* Taste transduction_Homo sapiens_hsa047423.69115341
2Fanconi anemia pathway_Homo sapiens_hsa034603.65465437
3Basal transcription factors_Homo sapiens_hsa030222.64857284
4Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.63429652
5Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.47026968
6Propanoate metabolism_Homo sapiens_hsa006402.37166955
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.34064592
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26194065
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23303858
10Systemic lupus erythematosus_Homo sapiens_hsa053222.23018675
11Alcoholism_Homo sapiens_hsa050342.14006866
12RNA degradation_Homo sapiens_hsa030182.05817401
13Circadian rhythm_Homo sapiens_hsa047101.98174884
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98088902
15Homologous recombination_Homo sapiens_hsa034401.89688077
16RNA transport_Homo sapiens_hsa030131.84614259
17Nitrogen metabolism_Homo sapiens_hsa009101.82063275
18Mismatch repair_Homo sapiens_hsa034301.82004025
19Protein export_Homo sapiens_hsa030601.79470579
20Nucleotide excision repair_Homo sapiens_hsa034201.74108180
21Spliceosome_Homo sapiens_hsa030401.70244499
22Non-homologous end-joining_Homo sapiens_hsa034501.52121857
23Steroid biosynthesis_Homo sapiens_hsa001001.46353973
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.39138529
25mRNA surveillance pathway_Homo sapiens_hsa030151.35703676
26Regulation of autophagy_Homo sapiens_hsa041401.30727364
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30132521
28One carbon pool by folate_Homo sapiens_hsa006701.25777834
29Prolactin signaling pathway_Homo sapiens_hsa049171.25227089
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22512824
31Basal cell carcinoma_Homo sapiens_hsa052171.19253748
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.19085981
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18821670
34Lysine degradation_Homo sapiens_hsa003101.18441035
35Selenocompound metabolism_Homo sapiens_hsa004501.17678416
36TGF-beta signaling pathway_Homo sapiens_hsa043501.11282512
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10869130
38Hedgehog signaling pathway_Homo sapiens_hsa043401.08553754
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.06826943
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02789233
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97949727
42Peroxisome_Homo sapiens_hsa041460.94777793
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94395128
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90299266
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89572352
46Viral carcinogenesis_Homo sapiens_hsa052030.89486548
47Type II diabetes mellitus_Homo sapiens_hsa049300.88346516
48Nicotine addiction_Homo sapiens_hsa050330.88137266
49Colorectal cancer_Homo sapiens_hsa052100.86410675
50Butanoate metabolism_Homo sapiens_hsa006500.83386362
51Cell cycle_Homo sapiens_hsa041100.80862824
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76647213
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.76392608
54Ether lipid metabolism_Homo sapiens_hsa005650.75212439
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75166430
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70516926
57Dopaminergic synapse_Homo sapiens_hsa047280.69417877
58Olfactory transduction_Homo sapiens_hsa047400.68772575
59Oocyte meiosis_Homo sapiens_hsa041140.68756298
60Collecting duct acid secretion_Homo sapiens_hsa049660.68637540
61Adherens junction_Homo sapiens_hsa045200.65114901
62Phototransduction_Homo sapiens_hsa047440.64983264
63p53 signaling pathway_Homo sapiens_hsa041150.61085925
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60456034
65HIF-1 signaling pathway_Homo sapiens_hsa040660.59489640
66ABC transporters_Homo sapiens_hsa020100.56777382
67RNA polymerase_Homo sapiens_hsa030200.56265559
68Choline metabolism in cancer_Homo sapiens_hsa052310.56163339
69Inositol phosphate metabolism_Homo sapiens_hsa005620.55739370
70Glutamatergic synapse_Homo sapiens_hsa047240.55708440
71Axon guidance_Homo sapiens_hsa043600.50650280
72Caffeine metabolism_Homo sapiens_hsa002320.49072351
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46924688
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45729039
75FoxO signaling pathway_Homo sapiens_hsa040680.43900542
76Morphine addiction_Homo sapiens_hsa050320.43739425
77ErbB signaling pathway_Homo sapiens_hsa040120.41576723
78Thyroid cancer_Homo sapiens_hsa052160.39500797
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38064608
80Long-term depression_Homo sapiens_hsa047300.37859395
81Wnt signaling pathway_Homo sapiens_hsa043100.37538423
82MicroRNAs in cancer_Homo sapiens_hsa052060.36583085
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36283595
84Dorso-ventral axis formation_Homo sapiens_hsa043200.35844091
85Hippo signaling pathway_Homo sapiens_hsa043900.34122694
86Base excision repair_Homo sapiens_hsa034100.32942746
87N-Glycan biosynthesis_Homo sapiens_hsa005100.32895902
88Endometrial cancer_Homo sapiens_hsa052130.32625349
89Tight junction_Homo sapiens_hsa045300.32516757
90Glucagon signaling pathway_Homo sapiens_hsa049220.31824175
91Cholinergic synapse_Homo sapiens_hsa047250.31725332
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31548493
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31043762
94Purine metabolism_Homo sapiens_hsa002300.30957150
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29559266
96Circadian entrainment_Homo sapiens_hsa047130.29085906
97mTOR signaling pathway_Homo sapiens_hsa041500.28725934
98Retinol metabolism_Homo sapiens_hsa008300.28071987
99Calcium signaling pathway_Homo sapiens_hsa040200.27949177
100GABAergic synapse_Homo sapiens_hsa047270.27803090

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »