TAS2R40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)7.48241689
2positive regulation by symbiont of host defense response (GO:0052509)7.14431368
3modulation by symbiont of host defense response (GO:0052031)7.14431368
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.14431368
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.14431368
6positive regulation by organism of defense response of other organism involved in symbiotic interact7.14431368
7modulation by symbiont of host immune response (GO:0052553)7.14431368
8positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)6.85587443
9regulation of interferon-beta biosynthetic process (GO:0045357)5.80713214
10macrophage activation involved in immune response (GO:0002281)5.68284520
11regulation of nitric-oxide synthase biosynthetic process (GO:0051769)5.56810241
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.52823829
13microglial cell activation (GO:0001774)5.52102944
14detection of external biotic stimulus (GO:0098581)5.41504682
15positive regulation of gamma-delta T cell activation (GO:0046645)5.41105476
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.39565678
17negative regulation of cell killing (GO:0031342)5.39565678
18neutrophil activation involved in immune response (GO:0002283)5.27689145
19cellular extravasation (GO:0045123)5.13658954
20positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.06245840
21response to host immune response (GO:0052572)4.92077920
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.92077920
23leukocyte migration involved in inflammatory response (GO:0002523)4.85761940
24macrophage activation (GO:0042116)4.83555360
25detection of other organism (GO:0098543)4.80245321
26regulation of B cell receptor signaling pathway (GO:0050855)4.70659863
27detection of biotic stimulus (GO:0009595)4.70087549
28neutrophil mediated immunity (GO:0002446)4.64767544
29neutrophil activation (GO:0042119)4.58152503
30response to peptidoglycan (GO:0032494)4.42076831
31response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.39326545
32response to host (GO:0075136)4.39326545
33response to host defenses (GO:0052200)4.39326545
34negative regulation of interleukin-12 production (GO:0032695)4.12295089
35negative regulation of lymphocyte mediated immunity (GO:0002707)4.08061234
36production of molecular mediator involved in inflammatory response (GO:0002532)4.04476398
37response to interleukin-15 (GO:0070672)4.01177751
38granulocyte activation (GO:0036230)4.00602975
39regulation of gamma-delta T cell activation (GO:0046643)3.96248054
40negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.94524618
41positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.91682570
42myeloid leukocyte mediated immunity (GO:0002444)3.91373963
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.88114760
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.88017845
45detection of bacterium (GO:0016045)3.86256826
46negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.85386736
47respiratory burst (GO:0045730)3.85019085
48myeloid cell activation involved in immune response (GO:0002275)3.84604484
49leukocyte aggregation (GO:0070486)3.75819516
50antigen processing and presentation of endogenous antigen (GO:0019883)3.75620484
51positive regulation of toll-like receptor signaling pathway (GO:0034123)3.72672913
52negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.69026006
53negative regulation of T-helper cell differentiation (GO:0045623)3.69026006
54regulation of gamma-delta T cell differentiation (GO:0045586)3.66204543
55cellular response to interleukin-15 (GO:0071350)3.60300082
56negative regulation of interleukin-1 production (GO:0032692)3.58338248
57regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.56618345
58negative regulation of immunoglobulin mediated immune response (GO:0002890)3.51572562
59negative regulation of B cell mediated immunity (GO:0002713)3.51572562
60positive regulation of interferon-alpha production (GO:0032727)3.49959501
61regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.49567043
62negative regulation of leukocyte mediated immunity (GO:0002704)3.38835796
63negative regulation of interleukin-1 beta production (GO:0032691)3.38568054
64positive regulation of macrophage cytokine production (GO:0060907)3.36668649
65negative regulation of T cell mediated immunity (GO:0002710)3.34983473
66B cell receptor signaling pathway (GO:0050853)3.31082499
67regulation of interleukin-6 biosynthetic process (GO:0045408)3.30753834
68antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28519456
69dendritic cell migration (GO:0036336)3.25374867
70positive regulation of mast cell activation (GO:0033005)3.24719226
71I-kappaB phosphorylation (GO:0007252)3.21652706
72regulation of interferon-alpha production (GO:0032647)3.21236152
73antigen processing and presentation via MHC class Ib (GO:0002475)3.20910963
74regulation of T-helper 2 cell differentiation (GO:0045628)3.15993385
75regulation of mast cell degranulation (GO:0043304)3.14372401
76T-helper 1 type immune response (GO:0042088)3.13953519
77negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.13825312
78neutrophil chemotaxis (GO:0030593)3.13659346
79regulation of mast cell activation (GO:0033003)3.11649921
80regulation of macrophage cytokine production (GO:0010935)3.10467222
81defense response to protozoan (GO:0042832)3.08417242
82neutrophil migration (GO:1990266)3.05659157
83leukocyte degranulation (GO:0043299)3.01308288
84immunoglobulin mediated immune response (GO:0016064)3.00269443
85germinal center formation (GO:0002467)2.97489252
86myeloid leukocyte activation (GO:0002274)2.96175140
87regulation of mast cell activation involved in immune response (GO:0033006)2.96043201
88negative regulation of interleukin-17 production (GO:0032700)2.94712662
89negative regulation of B cell proliferation (GO:0030889)2.93957581
90regulation of interleukin-8 biosynthetic process (GO:0045414)2.92806034
91negative regulation of adaptive immune response (GO:0002820)2.92356407
92dendritic cell chemotaxis (GO:0002407)2.91211360
93regulation of regulatory T cell differentiation (GO:0045589)2.89590104
94regulation of myeloid leukocyte mediated immunity (GO:0002886)2.89251307
95positive regulation of cellular amide metabolic process (GO:0034250)2.88507436
96activated T cell proliferation (GO:0050798)2.87928978
97pantothenate metabolic process (GO:0015939)2.83868993
98regulation of toll-like receptor signaling pathway (GO:0034121)2.82939947
99positive regulation of interferon-beta production (GO:0032728)2.80124582
100negative regulation of interleukin-6 production (GO:0032715)2.73508283

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.58201585
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.30030175
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.02756146
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.84155661
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.51472798
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.46745081
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.15381827
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.98604519
9RUNX_20019798_ChIP-Seq_JUKART_Human2.73359512
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67766083
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.62422390
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.51714619
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.48730323
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.43591930
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.40219286
16SPI1_23127762_ChIP-Seq_K562_Human2.39448974
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38423241
18SPI1_23547873_ChIP-Seq_NB4_Human2.29220729
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.23117794
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13303432
21SCL_19346495_ChIP-Seq_HPC-7_Human2.12421087
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.99095322
23VDR_24787735_ChIP-Seq_THP-1_Human1.93856046
24MYB_26560356_Chip-Seq_TH2_Human1.87452685
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82815619
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74376091
27VDR_24763502_ChIP-Seq_THP-1_Human1.74355065
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66474946
29PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64247204
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62444876
31SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59105678
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.56626553
33MYB_26560356_Chip-Seq_TH1_Human1.56218815
34GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.55080039
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48799499
36GATA1_19941827_ChIP-Seq_MEL_Mouse1.48397699
37GATA1_22025678_ChIP-Seq_K562_Human1.48104926
38GATA3_26560356_Chip-Seq_TH2_Human1.47605191
39GATA3_27048872_Chip-Seq_THYMUS_Human1.44745618
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44528210
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40616260
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36882868
43PU_27001747_Chip-Seq_BMDM_Mouse1.34633898
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.34335802
45RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.32784445
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32588362
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31348416
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30975914
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.30700402
50MAF_26560356_Chip-Seq_TH1_Human1.30647586
51GBX2_23144817_ChIP-Seq_PC3_Human1.26159393
52EZH2_22144423_ChIP-Seq_EOC_Human1.24009199
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20873822
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20246902
55UTX_26944678_Chip-Seq_JUKART_Human1.19632808
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17766413
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15866357
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15268293
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09236529
60SMRT_27268052_Chip-Seq_Bcells_Human1.04826567
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04809558
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04092336
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02809397
64DROSHA_22980978_ChIP-Seq_HELA_Human0.98669373
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98644059
66VDR_21846776_ChIP-Seq_THP-1_Human0.98126238
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97488614
68ER_23166858_ChIP-Seq_MCF-7_Human0.96386594
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96192296
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96192296
71GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95520395
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93450943
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92537364
74KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.91918599
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89959066
76GATA2_19941826_ChIP-Seq_K562_Human0.89455445
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89017593
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88279988
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86868116
80POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86502690
81SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85115115
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85097044
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82335016
84TCF7_22412390_ChIP-Seq_EML_Mouse0.81931944
85NFE2_27457419_Chip-Seq_LIVER_Mouse0.80339185
86TP53_16413492_ChIP-PET_HCT116_Human0.80091993
87GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79553734
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79119295
89PRDM14_20953172_ChIP-Seq_ESCs_Human0.78970939
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.77148422
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76959324
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.76690855
93GATA1_19941826_ChIP-Seq_K562_Human0.75422534
94TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.75136019
95KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74898957
96EGR1_19374776_ChIP-ChIP_THP-1_Human0.74483472
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.73769686
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.73015523
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73011227
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.72600635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to6.94426317
2MP0003436_decreased_susceptibility_to3.57233480
3MP0000569_abnormal_digit_pigmentation3.44139866
4MP0003303_peritoneal_inflammation3.36926696
5MP0001835_abnormal_antigen_presentation3.26202837
6MP0002419_abnormal_innate_immunity2.89398006
7MP0008260_abnormal_autophagy2.63596319
8MP0001800_abnormal_humoral_immune2.52450956
9MP0000015_abnormal_ear_pigmentation2.51372757
10MP0009785_altered_susceptibility_to2.49341209
11MP0005025_abnormal_response_to2.46310502
12MP0005671_abnormal_response_to2.42206640
13MP0004381_abnormal_hair_follicle2.39424458
14MP0005000_abnormal_immune_tolerance2.36852152
15MP0000685_abnormal_immune_system2.28616856
16MP0002723_abnormal_immune_serum2.28576700
17MP0005464_abnormal_platelet_physiology2.26105631
18MP0003191_abnormal_cellular_cholesterol2.23446597
19MP0002420_abnormal_adaptive_immunity2.14151114
20MP0001819_abnormal_immune_cell2.11935064
21MP0002452_abnormal_antigen_presenting2.11682418
22MP0005387_immune_system_phenotype2.08297227
23MP0001790_abnormal_immune_system2.08297227
24MP0002132_abnormal_respiratory_system2.03135318
25MP0001533_abnormal_skeleton_physiology1.97421693
26MP0006082_CNS_inflammation1.89131649
27MP0002148_abnormal_hypersensitivity_rea1.89017681
28MP0000465_gastrointestinal_hemorrhage1.87970446
29MP0003828_pulmonary_edema1.86041332
30MP0003787_abnormal_imprinting1.85942443
31MP0009278_abnormal_bone_marrow1.75235783
32MP0009764_decreased_sensitivity_to1.71863106
33MP0002277_abnormal_respiratory_mucosa1.71409315
34MP0004883_abnormal_blood_vessel1.68135544
35MP0005174_abnormal_tail_pigmentation1.64962849
36MP0002405_respiratory_system_inflammati1.63965283
37MP0002396_abnormal_hematopoietic_system1.61679507
38MP0005075_abnormal_melanosome_morpholog1.60171042
39MP0000716_abnormal_immune_system1.58863811
40MP0005451_abnormal_body_composition1.57840398
41MP0002398_abnormal_bone_marrow1.56978981
42MP0001845_abnormal_inflammatory_respons1.53147119
43MP0003172_abnormal_lysosome_physiology1.49048898
44MP0003183_abnormal_peptide_metabolism1.47097626
45MP0003866_abnormal_defecation1.45612044
46MP0003300_gastrointestinal_ulcer1.45486173
47MP0001545_abnormal_hematopoietic_system1.40952952
48MP0005397_hematopoietic_system_phenotyp1.40952952
49MP0003763_abnormal_thymus_physiology1.35289951
50MP0003690_abnormal_glial_cell1.35031236
51MP0004130_abnormal_muscle_cell1.34439824
52MP0003075_altered_response_to1.31979569
53MP0005164_abnormal_response_to1.30437990
54MP0008877_abnormal_DNA_methylation1.29097308
55MP0002722_abnormal_immune_system1.28684940
56MP0000689_abnormal_spleen_morphology1.27846137
57MP0010155_abnormal_intestine_physiology1.25813614
58MP0004947_skin_inflammation1.20229759
59MP0002429_abnormal_blood_cell1.18383139
60MP0008469_abnormal_protein_level1.10486997
61MP0002166_altered_tumor_susceptibility1.07267321
62MP0000703_abnormal_thymus_morphology1.06050391
63MP0008004_abnormal_stomach_pH1.05903408
64MP0000858_altered_metastatic_potential1.03528402
65MP0002998_abnormal_bone_remodeling1.03196954
66MP0001851_eye_inflammation1.02975347
67MP0003045_fibrosis1.01226947
68MP0004484_altered_response_of1.00325545
69MP0005409_darkened_coat_color0.98250699
70MP0005408_hypopigmentation0.96003310
71MP0000371_diluted_coat_color0.95041633
72MP0002332_abnormal_exercise_endurance0.94427363
73MP0000372_irregular_coat_pigmentation0.92596369
74MP0005310_abnormal_salivary_gland0.92035592
75MP0003221_abnormal_cardiomyocyte_apopto0.87976061
76MP0005377_hearing/vestibular/ear_phenot0.86253972
77MP0003878_abnormal_ear_physiology0.86253972
78MP0002095_abnormal_skin_pigmentation0.84307757
79MP0005083_abnormal_biliary_tract0.82563795
80MP0003656_abnormal_erythrocyte_physiolo0.77506965
81MP0005166_decreased_susceptibility_to0.77236350
82MP0004808_abnormal_hematopoietic_stem0.76015709
83MP0000604_amyloidosis0.75263844
84MP0002928_abnormal_bile_duct0.74399482
85MP0003136_yellow_coat_color0.72554273
86MP0002006_tumorigenesis0.70638644
87MP0000920_abnormal_myelination0.69913039
88MP0008874_decreased_physiological_sensi0.69600712
89MP0003448_altered_tumor_morphology0.69063042
90MP0009763_increased_sensitivity_to0.68849057
91MP0004510_myositis0.67765951
92MP0001663_abnormal_digestive_system0.67694877
93MP0002102_abnormal_ear_morphology0.66390852
94MP0003252_abnormal_bile_duct0.65476069
95MP0000343_altered_response_to0.64963447
96MP0008057_abnormal_DNA_replication0.64762378
97MP0009333_abnormal_splenocyte_physiolog0.64600672
98MP0001324_abnormal_eye_pigmentation0.63911714
99MP0005248_abnormal_Harderian_gland0.63282724
100MP0005390_skeleton_phenotype0.60933640

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)6.30174593
2Optic neuritis (HP:0100653)6.24775747
3Retrobulbar optic neuritis (HP:0100654)6.24775747
4Eczematoid dermatitis (HP:0000976)6.09045997
5Recurrent bacterial skin infections (HP:0005406)6.07215384
6Myositis (HP:0100614)6.05033823
7Recurrent abscess formation (HP:0002722)5.99338743
8Stomatitis (HP:0010280)5.11031792
9Keratoconjunctivitis sicca (HP:0001097)4.63471226
10Recurrent gram-negative bacterial infections (HP:0005420)4.62161837
11Abnormality of macrophages (HP:0004311)4.54566965
12Gastrointestinal infarctions (HP:0005244)4.54266422
13Elevated erythrocyte sedimentation rate (HP:0003565)4.40915347
14Keratoconjunctivitis (HP:0001096)4.29740835
15Recurrent fungal infections (HP:0002841)4.11326160
16Recurrent skin infections (HP:0001581)3.94278756
17Spontaneous hematomas (HP:0007420)3.89986040
18Peritonitis (HP:0002586)3.89275917
19Gingival bleeding (HP:0000225)3.80250953
20Encephalitis (HP:0002383)3.80096271
21Gingivitis (HP:0000230)3.75375236
22Recurrent cutaneous fungal infections (HP:0011370)3.67992544
23Chronic mucocutaneous candidiasis (HP:0002728)3.67992544
24Meningitis (HP:0001287)3.61898830
25Arterial thrombosis (HP:0004420)3.57805314
26Mediastinal lymphadenopathy (HP:0100721)3.55230528
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.54456304
28Obstructive lung disease (HP:0006536)3.52685451
29Chronic obstructive pulmonary disease (HP:0006510)3.52685451
30T lymphocytopenia (HP:0005403)3.41339025
31Abnormality of T cell number (HP:0011839)3.38330439
32Prolonged bleeding time (HP:0003010)3.34622453
33Hemoptysis (HP:0002105)3.25114228
34Episodic fever (HP:0001954)3.21611754
35Chest pain (HP:0100749)3.19496068
36Vasculitis (HP:0002633)3.16647035
37Urticaria (HP:0001025)3.14954587
38Pulmonary embolism (HP:0002204)3.09094764
39Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.08024444
40Epistaxis (HP:0000421)2.98286527
41Gangrene (HP:0100758)2.96849218
42Anorexia (HP:0002039)2.92093695
43Leukocytosis (HP:0001974)2.71419636
44Abnormality of the endocardium (HP:0004306)2.68466578
45Pulmonary infiltrates (HP:0002113)2.66617431
46Increased IgE level (HP:0003212)2.59727236
47Abnormality of T cells (HP:0002843)2.56663734
48Cellulitis (HP:0100658)2.52021398
49Abnormality of the peritoneum (HP:0002585)2.51008825
50Subacute progressive viral hepatitis (HP:0006572)2.50058440
51Abnormality of the pleura (HP:0002103)2.48207369
52Papilledema (HP:0001085)2.40588957
53Hypochromic microcytic anemia (HP:0004840)2.40437625
54Amyloidosis (HP:0011034)2.36261853
55Keratitis (HP:0000491)2.33525640
56Aplasia/Hypoplasia of the macula (HP:0008059)2.33305977
57Vertigo (HP:0002321)2.31019914
58Hypochromic anemia (HP:0001931)2.30578991
59Acute hepatic failure (HP:0006554)2.26062998
60Cheilitis (HP:0100825)2.24468221
61Sepsis (HP:0100806)2.17811012
62Inflammation of the large intestine (HP:0002037)2.17025958
63Choroideremia (HP:0001139)2.15167799
64Petechiae (HP:0000967)2.14651974
65Glomerulopathy (HP:0100820)2.14099632
66Increased IgM level (HP:0003496)2.12982233
67Osteomyelitis (HP:0002754)2.12812136
68Aplasia/Hypoplasia affecting the retina (HP:0008061)2.12373493
69Granulocytopenia (HP:0001913)2.08978460
70Eosinophilia (HP:0001880)2.08567716
71Difficulty running (HP:0009046)2.05413040
72Postural instability (HP:0002172)2.03069024
73Ocular albinism (HP:0001107)2.01026653
74Abnormal platelet volume (HP:0011876)1.98554892
75Viral hepatitis (HP:0006562)1.97270286
76Thrombophlebitis (HP:0004418)1.94691142
77Gastrointestinal inflammation (HP:0004386)1.94060348
78Dynein arm defect of respiratory motile cilia (HP:0012255)1.91859896
79Absent/shortened dynein arms (HP:0200106)1.91859896
80Abnormality of T cell physiology (HP:0011840)1.86456703
81Recurrent viral infections (HP:0004429)1.86093117
82Papillary thyroid carcinoma (HP:0002895)1.79693877
83Acne (HP:0001061)1.78615455
84Abnormality of the pericardium (HP:0001697)1.78583488
85Autoimmune hemolytic anemia (HP:0001890)1.78321510
86Neurodegeneration (HP:0002180)1.76663647
87Joint swelling (HP:0001386)1.76421161
88Microcytic anemia (HP:0001935)1.76127480
89Stomach cancer (HP:0012126)1.76009299
90Neoplasm of the tracheobronchial system (HP:0100552)1.72842053
91Abnormality of eosinophils (HP:0001879)1.72459290
92Autoimmune thrombocytopenia (HP:0001973)1.72277942
93Resting tremor (HP:0002322)1.70882792
94Chronic otitis media (HP:0000389)1.70415099
95Polyneuropathy (HP:0001271)1.70261766
96Menorrhagia (HP:0000132)1.68761929
97Onion bulb formation (HP:0003383)1.67768430
98Skin ulcer (HP:0200042)1.66354922
99Recurrent pneumonia (HP:0006532)1.66344950
100Skin rash (HP:0000988)1.63928343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.90583217
2IRAK43.55972679
3BLK3.55657728
4MAP2K32.89772020
5CSK2.68273763
6TYK22.39777045
7EPHB12.34491143
8FES2.26121477
9ZAP702.04219382
10MAP3K21.99330001
11GRK61.95886060
12MAP4K11.95796595
13IRAK11.88905472
14FGR1.85515476
15TXK1.85194533
16BTK1.84584617
17TNK21.83582061
18SIK21.82310799
19TAOK31.81376704
20JAK21.81172179
21HCK1.80451183
22KSR21.71505914
23SYK1.63393851
24YES11.62915991
25ERN11.61783138
26PIK3CG1.57676799
27MAP3K61.52844894
28FRK1.52546413
29IRAK21.50229322
30JAK31.47680054
31LYN1.41025720
32IKBKE1.39101708
33TAOK11.36305176
34MARK31.35923949
35MAP3K31.30021173
36JAK11.29150943
37MAP3K11.19857395
38PTK2B1.18578962
39BMPR21.13228187
40RAF11.11262144
41WNK11.10999182
42MAP2K41.09794016
43MATK1.08593913
44TEC1.04689229
45MAP3K111.01960578
46CDK190.97263242
47KSR10.95520068
48LCK0.95277969
49MAP3K140.91657081
50ITK0.89473974
51ACVR1B0.88354281
52FGFR30.86995965
53DAPK20.86506779
54SIK30.85891320
55MARK20.85609824
56LRRK20.82670619
57MAP3K50.82331374
58NTRK30.81446689
59SGK20.81038204
60TGFBR20.80978147
61CSF1R0.78491524
62EPHA30.77871746
63PRKCH0.77017967
64SGK30.75435182
65FYN0.74445709
66PDK10.73651603
67RET0.72754287
68STK110.71955373
69KIT0.71842788
70OXSR10.71449533
71PAK30.69558625
72MAP2K60.67666973
73PTK60.67229976
74STK380.65747797
75TBK10.64638297
76DYRK1B0.59354287
77DYRK30.55099985
78PDPK10.54503295
79PRKCZ0.51719081
80ERBB20.46971685
81CAMKK20.45528180
82MAP3K70.42986037
83NLK0.40618851
84SGK2230.40341951
85SGK4940.40341951
86PRKD20.40111999
87PRKD10.36828701
88EGFR0.35870119
89IKBKB0.35404149
90PRKCQ0.34677876
91PRPF4B0.34375414
92ADRBK10.33102479
93DYRK1A0.32564329
94STK100.32241443
95MAPKAPK20.31092637
96BCR0.31018461
97CAMK40.30252260
98SGK10.29521975
99DMPK0.28817356
100PIM10.28193027

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.94371637
2Osteoclast differentiation_Homo sapiens_hsa043802.82702822
3Staphylococcus aureus infection_Homo sapiens_hsa051502.55527464
4Tuberculosis_Homo sapiens_hsa051522.30297562
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.26929440
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.24596194
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.21394862
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.16371648
9Legionellosis_Homo sapiens_hsa051342.00374956
10B cell receptor signaling pathway_Homo sapiens_hsa046621.93570134
11Measles_Homo sapiens_hsa051621.86678031
12Malaria_Homo sapiens_hsa051441.80235417
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.77508173
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.75884928
15Chemokine signaling pathway_Homo sapiens_hsa040621.75210639
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.62759891
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51332856
18Platelet activation_Homo sapiens_hsa046111.48552912
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46092529
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.44878657
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.40213106
22Hematopoietic cell lineage_Homo sapiens_hsa046401.39161161
23Non-small cell lung cancer_Homo sapiens_hsa052231.38799702
24T cell receptor signaling pathway_Homo sapiens_hsa046601.38232813
25Toxoplasmosis_Homo sapiens_hsa051451.38101932
26Phagosome_Homo sapiens_hsa041451.36268214
27TNF signaling pathway_Homo sapiens_hsa046681.33611060
28Influenza A_Homo sapiens_hsa051641.31989128
29Acute myeloid leukemia_Homo sapiens_hsa052211.31485540
30Graft-versus-host disease_Homo sapiens_hsa053321.29601262
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28459897
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.24442223
33Hepatitis B_Homo sapiens_hsa051611.23990238
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19200796
35Primary immunodeficiency_Homo sapiens_hsa053401.18203860
36Allograft rejection_Homo sapiens_hsa053301.17734671
37Autoimmune thyroid disease_Homo sapiens_hsa053201.11596986
38African trypanosomiasis_Homo sapiens_hsa051431.09185608
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08119341
40Pancreatic cancer_Homo sapiens_hsa052121.03852820
41Salmonella infection_Homo sapiens_hsa051321.02431188
42Herpes simplex infection_Homo sapiens_hsa051681.01988190
43Inositol phosphate metabolism_Homo sapiens_hsa005621.01493581
44Dorso-ventral axis formation_Homo sapiens_hsa043200.99734315
45Prolactin signaling pathway_Homo sapiens_hsa049170.96242357
46Hepatitis C_Homo sapiens_hsa051600.95743359
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94983693
48Renal cell carcinoma_Homo sapiens_hsa052110.94382903
49VEGF signaling pathway_Homo sapiens_hsa043700.90878553
50Apoptosis_Homo sapiens_hsa042100.89642352
51FoxO signaling pathway_Homo sapiens_hsa040680.87741489
52Pertussis_Homo sapiens_hsa051330.87108528
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85773802
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.84380975
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.83216907
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81010413
57Regulation of autophagy_Homo sapiens_hsa041400.80059248
58Antigen processing and presentation_Homo sapiens_hsa046120.78920638
59Shigellosis_Homo sapiens_hsa051310.78085894
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77879902
61Type I diabetes mellitus_Homo sapiens_hsa049400.76951877
62Chronic myeloid leukemia_Homo sapiens_hsa052200.76423462
63Endometrial cancer_Homo sapiens_hsa052130.75362618
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74298544
65Viral myocarditis_Homo sapiens_hsa054160.74066274
66Endocytosis_Homo sapiens_hsa041440.73551518
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72170604
68Type II diabetes mellitus_Homo sapiens_hsa049300.71206661
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.70890024
70Morphine addiction_Homo sapiens_hsa050320.70719056
71GnRH signaling pathway_Homo sapiens_hsa049120.69415317
72Prostate cancer_Homo sapiens_hsa052150.68932583
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67817284
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.67190734
75Rap1 signaling pathway_Homo sapiens_hsa040150.65955032
76Amoebiasis_Homo sapiens_hsa051460.64979131
77Choline metabolism in cancer_Homo sapiens_hsa052310.63204986
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61647020
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61046447
80ErbB signaling pathway_Homo sapiens_hsa040120.60588037
81Insulin resistance_Homo sapiens_hsa049310.59268440
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59097566
83MAPK signaling pathway_Homo sapiens_hsa040100.57922097
84Viral carcinogenesis_Homo sapiens_hsa052030.57687868
85Fatty acid biosynthesis_Homo sapiens_hsa000610.56803085
86Cholinergic synapse_Homo sapiens_hsa047250.56619936
87Glioma_Homo sapiens_hsa052140.56189178
88Estrogen signaling pathway_Homo sapiens_hsa049150.54378351
89mTOR signaling pathway_Homo sapiens_hsa041500.54208230
90HIF-1 signaling pathway_Homo sapiens_hsa040660.51574589
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51526140
92Rheumatoid arthritis_Homo sapiens_hsa053230.49695978
93Colorectal cancer_Homo sapiens_hsa052100.49560280
94Serotonergic synapse_Homo sapiens_hsa047260.48601304
95Ras signaling pathway_Homo sapiens_hsa040140.46095357
96Gastric acid secretion_Homo sapiens_hsa049710.45765578
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.45380876
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44779480
99Long-term potentiation_Homo sapiens_hsa047200.44010219
100cAMP signaling pathway_Homo sapiens_hsa040240.43392265

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