TAS2R43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of action potential (GO:0045760)5.59910269
2tachykinin receptor signaling pathway (GO:0007217)5.23417708
3somite rostral/caudal axis specification (GO:0032525)4.81991292
4neurotransmitter-gated ion channel clustering (GO:0072578)4.56397166
5neural tube formation (GO:0001841)4.48955856
6negative regulation of translation, ncRNA-mediated (GO:0040033)4.45670910
7regulation of translation, ncRNA-mediated (GO:0045974)4.45670910
8negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.45670910
9cytoplasmic mRNA processing body assembly (GO:0033962)4.40744960
10regulation of action potential (GO:0098900)4.38258192
11behavioral response to ethanol (GO:0048149)4.35309437
12cell wall macromolecule catabolic process (GO:0016998)4.26306425
13regulation of establishment of cell polarity (GO:2000114)4.16041478
14acrosome assembly (GO:0001675)4.05752724
15retinal ganglion cell axon guidance (GO:0031290)3.96386296
16heparin biosynthetic process (GO:0030210)3.83822230
17heparin metabolic process (GO:0030202)3.83822230
18regulation of glucocorticoid secretion (GO:2000849)3.83522585
19platelet dense granule organization (GO:0060155)3.78770957
20* detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.76569471
21positive regulation of developmental pigmentation (GO:0048087)3.73533249
22proline transport (GO:0015824)3.73509686
23negative regulation of multicellular organism growth (GO:0040015)3.69185352
24interkinetic nuclear migration (GO:0022027)3.67892871
25protein localization to cilium (GO:0061512)3.67683530
26negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.66805657
27regulation of establishment or maintenance of cell polarity (GO:0032878)3.59237714
28calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.58200814
29regulation of pigment cell differentiation (GO:0050932)3.55410958
30sex differentiation (GO:0007548)3.45298181
31cell wall macromolecule metabolic process (GO:0044036)3.42773010
32microtubule anchoring (GO:0034453)3.42616636
33left/right axis specification (GO:0070986)3.39438084
34* detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.37394058
35nuclear pore complex assembly (GO:0051292)3.36604860
36regulation of telomere maintenance (GO:0032204)3.33803396
37positive regulation of protein deacetylation (GO:0090312)3.32983565
38regulation of feeding behavior (GO:0060259)3.29129862
39cerebellar Purkinje cell differentiation (GO:0021702)3.28938884
40regulation of memory T cell differentiation (GO:0043380)3.24172610
41synapsis (GO:0007129)3.16176426
42negative regulation of heart rate (GO:0010459)3.14659776
43stress granule assembly (GO:0034063)3.09589399
44DNA ligation (GO:0006266)3.07702902
45establishment of protein localization to Golgi (GO:0072600)3.07031949
46neuronal action potential propagation (GO:0019227)3.06815499
47homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)3.06578176
48pyrimidine nucleobase catabolic process (GO:0006208)3.03224721
49monoubiquitinated protein deubiquitination (GO:0035520)2.98749177
50central nervous system projection neuron axonogenesis (GO:0021952)2.97726639
51behavioral response to nicotine (GO:0035095)2.94261330
52synaptic transmission, cholinergic (GO:0007271)2.92134888
53regulation of MHC class I biosynthetic process (GO:0045343)2.91756537
54regulation of corticosteroid hormone secretion (GO:2000846)2.91442627
55phosphatidylethanolamine biosynthetic process (GO:0006646)2.90967373
56regulation of protein deacetylation (GO:0090311)2.89359927
57nuclear pore organization (GO:0006999)2.88659729
58central nervous system neuron axonogenesis (GO:0021955)2.87158293
59intraciliary transport (GO:0042073)2.85394807
60prenylation (GO:0097354)2.82164267
61protein prenylation (GO:0018342)2.82164267
62substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.81510273
63substrate-independent telencephalic tangential migration (GO:0021826)2.81510273
64microtubule nucleation (GO:0007020)2.81327814
65pore complex assembly (GO:0046931)2.80519265
66RNA destabilization (GO:0050779)2.75992571
67ADP metabolic process (GO:0046031)2.75611674
68forebrain neuron development (GO:0021884)2.74695193
69phospholipid translocation (GO:0045332)2.74655046
70lipid translocation (GO:0034204)2.74655046
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74376911
72positive regulation of steroid hormone secretion (GO:2000833)2.73754952
73alternative mRNA splicing, via spliceosome (GO:0000380)2.70590041
74regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.69704911
75phosphatidylethanolamine metabolic process (GO:0046337)2.69689700
76oxidative demethylation (GO:0070989)2.68237881
77positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.68130023
78regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.68130023
79interferon-gamma production (GO:0032609)2.67424432
80protein localization to Golgi apparatus (GO:0034067)2.66734683
81positive regulation of digestive system process (GO:0060456)2.66687216
82kynurenine metabolic process (GO:0070189)2.66642607
83CENP-A containing nucleosome assembly (GO:0034080)2.66392174
84prostate gland growth (GO:0060736)2.64544491
85DNA topological change (GO:0006265)2.62924656
86nucleobase catabolic process (GO:0046113)2.62562679
87nucleus localization (GO:0051647)2.59109426
88negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.58459748
89chromatin remodeling at centromere (GO:0031055)2.57419864
90positive regulation of synaptic transmission, GABAergic (GO:0032230)2.55328546
91RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.54838462
92synapse assembly (GO:0007416)2.54647425
93neuron recognition (GO:0008038)2.54357416
94centrosome duplication (GO:0051298)2.54296066
95histone exchange (GO:0043486)2.53167077
96resolution of meiotic recombination intermediates (GO:0000712)2.53067263
97positive regulation of dendritic spine morphogenesis (GO:0061003)2.53035767
98ncRNA catabolic process (GO:0034661)2.52684181
99male meiosis (GO:0007140)2.51887162
100response to X-ray (GO:0010165)2.51880198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.81904553
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.67895670
3POU3F2_20337985_ChIP-ChIP_501MEL_Human3.64151049
4TAF15_26573619_Chip-Seq_HEK293_Human3.59062669
5FUS_26573619_Chip-Seq_HEK293_Human3.38736487
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.13940208
7ZNF274_21170338_ChIP-Seq_K562_Hela3.12387120
8GBX2_23144817_ChIP-Seq_PC3_Human3.05369865
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.86807199
10IGF1R_20145208_ChIP-Seq_DFB_Human2.85344615
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.84966768
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81551702
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39940944
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.36305480
15VDR_22108803_ChIP-Seq_LS180_Human2.36178450
16EWS_26573619_Chip-Seq_HEK293_Human2.34801493
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.33525051
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.13688416
19ER_23166858_ChIP-Seq_MCF-7_Human2.12049408
20P300_19829295_ChIP-Seq_ESCs_Human2.09385686
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.01984746
22SMAD4_21799915_ChIP-Seq_A2780_Human1.97360571
23UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.92303949
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.90040996
25MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.89137075
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.87510849
27OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87397634
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.87065374
29STAT3_23295773_ChIP-Seq_U87_Human1.85223667
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.72843606
31CBP_20019798_ChIP-Seq_JUKART_Human1.72843606
32TCF4_23295773_ChIP-Seq_U87_Human1.68003537
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67173542
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60477048
35BCAT_22108803_ChIP-Seq_LS180_Human1.58922666
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56729812
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55258865
38AR_25329375_ChIP-Seq_VCAP_Human1.53922315
39KLF5_20875108_ChIP-Seq_MESCs_Mouse1.47528577
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40998084
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.40326296
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39999004
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39713543
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35351102
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34913833
46RUNX2_22187159_ChIP-Seq_PCA_Human1.34004479
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33309058
48FLI1_21867929_ChIP-Seq_TH2_Mouse1.33117093
49E2F1_18555785_Chip-Seq_ESCs_Mouse1.31857732
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31800370
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31800370
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.31090635
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30800759
54ELK1_19687146_ChIP-ChIP_HELA_Human1.30343589
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.30238240
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28657027
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24633361
58TAL1_26923725_Chip-Seq_HPCs_Mouse1.23358655
59P53_22387025_ChIP-Seq_ESCs_Mouse1.23152454
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.21912811
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.21351008
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19901505
63OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19686699
64AR_21572438_ChIP-Seq_LNCaP_Human1.17941310
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17713275
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.16907815
67TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15269488
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14512498
69KDM2B_26808549_Chip-Seq_REH_Human1.14096191
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13714598
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13476618
72TCF4_22108803_ChIP-Seq_LS180_Human1.13181509
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11132236
74TP53_22573176_ChIP-Seq_HFKS_Human1.11051147
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.10027451
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.09031827
77TCF4_18268006_ChIP-ChIP_LS174T_Human1.08437112
78TP53_18474530_ChIP-ChIP_U2OS_Human1.07029395
79P300_18555785_Chip-Seq_ESCs_Mouse1.05488142
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.04081964
81RNF2_27304074_Chip-Seq_NSC_Mouse1.03862153
82CDX2_22108803_ChIP-Seq_LS180_Human1.03392465
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03019589
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02473065
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02458486
86TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02409472
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.02360294
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00516558
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98178563
90WT1_19549856_ChIP-ChIP_CCG9911_Human0.96603443
91STAT3_18555785_Chip-Seq_ESCs_Mouse0.96527279
92SALL4_22934838_ChIP-ChIP_CD34+_Human0.96076468
93JUN_21703547_ChIP-Seq_K562_Human0.95787468
94ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95409437
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95265513
96EZH2_22144423_ChIP-Seq_EOC_Human0.93655753
97SOX2_18555785_Chip-Seq_ESCs_Mouse0.93257720
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93169809
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92823868
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92330849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.15424304
2MP0010386_abnormal_urinary_bladder4.23570017
3MP0000516_abnormal_urinary_system4.00138143
4MP0005367_renal/urinary_system_phenotyp4.00138143
5MP0003880_abnormal_central_pattern3.94213023
6MP0003890_abnormal_embryonic-extraembry3.16432539
7MP0008057_abnormal_DNA_replication3.07563435
8MP0002736_abnormal_nociception_after2.95439323
9MP0002102_abnormal_ear_morphology2.48462823
10MP0005670_abnormal_white_adipose2.27980140
11MP0003183_abnormal_peptide_metabolism2.24548213
12MP0000015_abnormal_ear_pigmentation2.19135086
13MP0001968_abnormal_touch/_nociception2.17228692
14MP0005253_abnormal_eye_physiology2.11770122
15MP0001486_abnormal_startle_reflex1.92449320
16MP0003252_abnormal_bile_duct1.88696077
17MP0000372_irregular_coat_pigmentation1.85490635
18MP0006292_abnormal_olfactory_placode1.84885571
19MP0001501_abnormal_sleep_pattern1.77482237
20MP0003221_abnormal_cardiomyocyte_apopto1.77113547
21MP0001529_abnormal_vocalization1.73543452
22MP0002095_abnormal_skin_pigmentation1.63427908
23MP0005187_abnormal_penis_morphology1.58762259
24MP0005174_abnormal_tail_pigmentation1.54927990
25MP0008058_abnormal_DNA_repair1.51489554
26MP0002751_abnormal_autonomic_nervous1.50920181
27MP0010094_abnormal_chromosome_stability1.40642255
28MP0009745_abnormal_behavioral_response1.37908685
29MP0005551_abnormal_eye_electrophysiolog1.35806466
30MP0001177_atelectasis1.33816599
31MP0005248_abnormal_Harderian_gland1.32436029
32MP0009697_abnormal_copulation1.31600178
33MP0002234_abnormal_pharynx_morphology1.30016454
34MP0001986_abnormal_taste_sensitivity1.19968749
35MP0003195_calcinosis1.19713946
36MP0005075_abnormal_melanosome_morpholog1.17239687
37MP0000371_diluted_coat_color1.17107744
38MP0004133_heterotaxia1.15598655
39MP0009046_muscle_twitch1.13145373
40MP0008877_abnormal_DNA_methylation1.12882835
41MP0006035_abnormal_mitochondrial_morpho1.12305502
42MP0005266_abnormal_metabolism1.08648806
43MP0001324_abnormal_eye_pigmentation1.07471954
44MP0006072_abnormal_retinal_apoptosis1.07171085
45MP0004043_abnormal_pH_regulation1.06610995
46MP0002272_abnormal_nervous_system1.05868896
47MP0001984_abnormal_olfaction1.02801860
48MP0003011_delayed_dark_adaptation1.02343312
49MP0002837_dystrophic_cardiac_calcinosis1.02263128
50MP0003937_abnormal_limbs/digits/tail_de1.01839186
51MP0006276_abnormal_autonomic_nervous1.00984890
52MP0003879_abnormal_hair_cell0.98693016
53MP0010307_abnormal_tumor_latency0.98677531
54MP0002572_abnormal_emotion/affect_behav0.97989473
55MP0002160_abnormal_reproductive_system0.97855010
56MP0000427_abnormal_hair_cycle0.97373060
57MP0004142_abnormal_muscle_tone0.95917259
58MP0002067_abnormal_sensory_capabilities0.93646637
59MP0005646_abnormal_pituitary_gland0.93436534
60MP0000631_abnormal_neuroendocrine_gland0.93056136
61MP0008961_abnormal_basal_metabolism0.92949521
62MP0005391_vision/eye_phenotype0.92649399
63MP0003635_abnormal_synaptic_transmissio0.92145582
64MP0003693_abnormal_embryo_hatching0.91602828
65MP0003646_muscle_fatigue0.90675479
66MP0002229_neurodegeneration0.88431736
67MP0002184_abnormal_innervation0.87763113
68MP0001145_abnormal_male_reproductive0.86548591
69MP0002063_abnormal_learning/memory/cond0.85951262
70MP0001270_distended_abdomen0.85650471
71MP0000653_abnormal_sex_gland0.84475745
72MP0003698_abnormal_male_reproductive0.84317722
73MP0004924_abnormal_behavior0.83267035
74MP0005386_behavior/neurological_phenoty0.83267035
75MP0002882_abnormal_neuron_morphology0.82544453
76MP0008007_abnormal_cellular_replicative0.80656118
77MP0002735_abnormal_chemical_nociception0.80288657
78MP0004145_abnormal_muscle_electrophysio0.77318824
79MP0002210_abnormal_sex_determination0.76809975
80MP0003718_maternal_effect0.75728721
81MP0003119_abnormal_digestive_system0.74992804
82MP0005083_abnormal_biliary_tract0.72556045
83MP0004215_abnormal_myocardial_fiber0.72438402
84MP0005195_abnormal_posterior_eye0.71608753
85MP0000383_abnormal_hair_follicle0.71559844
86MP0002928_abnormal_bile_duct0.71264138
87MP0000778_abnormal_nervous_system0.71247193
88MP0002064_seizures0.70638738
89MP0009115_abnormal_fat_cell0.70416210
90MP0001929_abnormal_gametogenesis0.70336993
91MP0000955_abnormal_spinal_cord0.70197898
92MP0004811_abnormal_neuron_physiology0.68746689
93MP0003077_abnormal_cell_cycle0.68716436
94MP0003111_abnormal_nucleus_morphology0.68275282
95MP0005408_hypopigmentation0.67218025
96MP0002938_white_spotting0.66754965
97MP0003950_abnormal_plasma_membrane0.66389303
98MP0000358_abnormal_cell_content/0.65810277
99MP0002752_abnormal_somatic_nervous0.65292662
100MP0001188_hyperpigmentation0.64224610

Predicted human phenotypes

RankGene SetZ-score
1Failure to thrive in infancy (HP:0001531)4.80630657
2Febrile seizures (HP:0002373)4.73946079
3Genetic anticipation (HP:0003743)4.66041926
4Gaze-evoked nystagmus (HP:0000640)3.68710152
5Papillary thyroid carcinoma (HP:0002895)3.66181780
6Prostate neoplasm (HP:0100787)3.61277524
7Progressive cerebellar ataxia (HP:0002073)3.59239121
8Rib fusion (HP:0000902)3.32831440
9Molar tooth sign on MRI (HP:0002419)3.16357720
10Abnormality of midbrain morphology (HP:0002418)3.16357720
11Urinary bladder sphincter dysfunction (HP:0002839)3.11847546
12Focal motor seizures (HP:0011153)3.06864215
13Dysmetric saccades (HP:0000641)3.02713389
14Action tremor (HP:0002345)2.91838795
15Drooling (HP:0002307)2.81987960
16Intestinal atresia (HP:0011100)2.72096258
17Medial flaring of the eyebrow (HP:0010747)2.71792287
18Thyroid carcinoma (HP:0002890)2.70130566
19Pancreatic fibrosis (HP:0100732)2.69642894
20Absent speech (HP:0001344)2.68723806
21Pancreatic cysts (HP:0001737)2.66894001
22Postnatal microcephaly (HP:0005484)2.64221467
23Abnormal protein glycosylation (HP:0012346)2.64043929
24Abnormal glycosylation (HP:0012345)2.64043929
25Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.64043929
26Abnormal protein N-linked glycosylation (HP:0012347)2.64043929
27Excessive salivation (HP:0003781)2.59031709
28Aplasia/Hypoplasia of the tibia (HP:0005772)2.57926126
29Congenital primary aphakia (HP:0007707)2.52149700
30Oculomotor apraxia (HP:0000657)2.50198866
31Hyperventilation (HP:0002883)2.49120518
32Renal cortical cysts (HP:0000803)2.48337665
33Gait imbalance (HP:0002141)2.46111424
34Fair hair (HP:0002286)2.44492529
35Postaxial foot polydactyly (HP:0001830)2.38848073
36Abnormal biliary tract physiology (HP:0012439)2.35550549
37Bile duct proliferation (HP:0001408)2.35550549
38Pendular nystagmus (HP:0012043)2.34703824
39Narrow forehead (HP:0000341)2.34599634
40Cerebellar dysplasia (HP:0007033)2.34591331
41Widely spaced teeth (HP:0000687)2.33052603
42Nephrogenic diabetes insipidus (HP:0009806)2.30513041
43True hermaphroditism (HP:0010459)2.30499400
44Renal hypoplasia (HP:0000089)2.30087803
45Abnormality of the musculature of the pelvis (HP:0001469)2.29633361
46Abnormality of the hip-girdle musculature (HP:0001445)2.29633361
47Dialeptic seizures (HP:0011146)2.29600103
48Focal seizures (HP:0007359)2.28608577
49Abnormality of the astrocytes (HP:0100707)2.26570307
50Astrocytoma (HP:0009592)2.26570307
51Pelvic girdle muscle weakness (HP:0003749)2.26120397
52Protruding tongue (HP:0010808)2.22636792
53Abnormality of the renal cortex (HP:0011035)2.22567855
54Hemiparesis (HP:0001269)2.20945531
55Impaired vibratory sensation (HP:0002495)2.20377112
56Poor coordination (HP:0002370)2.18192816
57Median cleft lip (HP:0000161)2.16564451
58Amyotrophic lateral sclerosis (HP:0007354)2.14507740
59Shoulder girdle muscle weakness (HP:0003547)2.14124622
60Lissencephaly (HP:0001339)2.10503677
61Nephronophthisis (HP:0000090)2.09308340
62Split foot (HP:0001839)2.08014645
63Abnormality of the renal medulla (HP:0100957)2.07501981
64Hypoplastic labia majora (HP:0000059)2.07199398
65Colon cancer (HP:0003003)2.04041419
66Epidermoid cyst (HP:0200040)2.01913493
67Glioma (HP:0009733)1.98782385
68Inability to walk (HP:0002540)1.96730386
69Absence seizures (HP:0002121)1.95489816
70Chronic hepatic failure (HP:0100626)1.94310340
71Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.94139377
72Short 4th metacarpal (HP:0010044)1.94139377
73Genital tract atresia (HP:0001827)1.93553256
74Short tibia (HP:0005736)1.92638664
75Severe global developmental delay (HP:0011344)1.92144944
76Postaxial hand polydactyly (HP:0001162)1.91913022
77Abnormality of the labia majora (HP:0012881)1.91535123
78Polymicrogyria (HP:0002126)1.91311372
79Vaginal atresia (HP:0000148)1.89921151
80Generalized hypopigmentation of hair (HP:0011358)1.89409783
81Progressive inability to walk (HP:0002505)1.88146062
82Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87862550
83Degeneration of the lateral corticospinal tracts (HP:0002314)1.87862550
84Cortical dysplasia (HP:0002539)1.86769026
85Spastic paraplegia (HP:0001258)1.86703008
86Proximal amyotrophy (HP:0007126)1.85854219
87Neoplasm of the heart (HP:0100544)1.83858528
88Retinal dysplasia (HP:0007973)1.83154269
89Abnormality of the prostate (HP:0008775)1.81300682
90Abnormality of the hepatic vasculature (HP:0006707)1.81156264
91Ependymoma (HP:0002888)1.77969400
92Abnormality of DNA repair (HP:0003254)1.76441861
93Hyperglycinemia (HP:0002154)1.76196983
94Abnormal auditory evoked potentials (HP:0006958)1.76022348
95Lower limb muscle weakness (HP:0007340)1.74442399
96Inappropriate behavior (HP:0000719)1.74281318
97Sloping forehead (HP:0000340)1.73390037
98Abnormality of chromosome stability (HP:0003220)1.72555814
99Birth length less than 3rd percentile (HP:0003561)1.72185307
100Paraplegia (HP:0010550)1.72005551

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.78542979
2MAP3K44.56173525
3MAP2K73.84819147
4CDK193.34207555
5FGFR33.18980415
6MAPK132.27640805
7STK38L2.21553903
8BCR2.17914281
9TAF12.14551190
10NTRK32.10303948
11MAP3K62.09539599
12DYRK1A2.00999864
13TRIM281.98928101
14OXSR11.93718288
15ERBB31.88094773
16WNK31.85185679
17SRPK11.77527605
18MKNK21.76691818
19MAP2K41.76371851
20AKT31.55308394
21EPHA41.43483283
22MAP4K21.41105405
23ZAK1.40835148
24MKNK11.40441291
25PIK3CA1.39749524
26DYRK31.36752067
27STK381.35796354
28MAP3K51.23322471
29MARK11.21920941
30CASK1.10343493
31ACVR1B1.06897186
32NEK11.04015937
33PBK0.94701070
34BRSK20.92459080
35OBSCN0.90358591
36RPS6KA40.88101136
37TEC0.87984140
38SGK20.87944847
39NUAK10.87257725
40CAMKK20.85114638
41CSNK1A1L0.83428834
42CDK30.83094770
43CSNK1G20.82963209
44PLK40.81672419
45BLK0.81479051
46EPHA30.81414474
47DYRK1B0.79831098
48ERBB20.78019358
49VRK10.77953086
50ATR0.76186548
51BMPR20.76039503
52ADRBK20.73377935
53MAP3K70.71788712
54CSNK1G30.63010661
55ATM0.62665659
56CSNK1G10.61794304
57ERBB40.61025149
58BMPR1B0.60560585
59SGK10.58372203
60TRPM70.55931659
61PLK30.54837055
62PLK10.54098159
63PLK20.53493486
64GRK10.53384986
65SGK2230.52700839
66SGK4940.52700839
67DYRK20.52405615
68TTK0.52196073
69FLT30.51177806
70CAMK40.46811164
71TAOK30.46627748
72RPS6KA50.45851821
73PIM10.45407343
74LATS10.44090951
75STK110.43901599
76SIK20.43628292
77CAMK2A0.42034429
78RPS6KB10.41267774
79TLK10.40734771
80CLK10.40396514
81FER0.39933284
82PKN10.39073475
83INSRR0.38914743
84STK40.38320946
85AURKB0.36723037
86TXK0.36577731
87CAMK2B0.35734619
88PIM20.35386731
89WNK10.35120447
90PRKACB0.34862894
91NEK60.33225165
92CHEK10.31172700
93RET0.30602790
94PRKG10.30224070
95CSNK1E0.29825402
96PRKCE0.28924926
97EGFR0.27912159
98CSNK1D0.27079325
99PINK10.26745105
100CHEK20.24769015

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.95520726
2Propanoate metabolism_Homo sapiens_hsa006403.80944802
3Steroid biosynthesis_Homo sapiens_hsa001003.26698482
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.18542419
5* Taste transduction_Homo sapiens_hsa047422.92051765
6Nicotine addiction_Homo sapiens_hsa050332.55241527
7Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.30376369
8Cysteine and methionine metabolism_Homo sapiens_hsa002702.22851977
9Butanoate metabolism_Homo sapiens_hsa006502.20824308
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02515917
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95035703
12Fanconi anemia pathway_Homo sapiens_hsa034601.92004517
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.86179784
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79622311
15Non-homologous end-joining_Homo sapiens_hsa034501.77181764
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.70444768
17Caffeine metabolism_Homo sapiens_hsa002321.69718945
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60439687
19Basal transcription factors_Homo sapiens_hsa030221.52092776
20Pyruvate metabolism_Homo sapiens_hsa006201.46471707
21Long-term depression_Homo sapiens_hsa047301.46378822
22Circadian rhythm_Homo sapiens_hsa047101.45862149
23Glutamatergic synapse_Homo sapiens_hsa047241.41651367
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35681561
25RNA degradation_Homo sapiens_hsa030181.33897407
26Homologous recombination_Homo sapiens_hsa034401.30518460
27Olfactory transduction_Homo sapiens_hsa047401.23708309
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21278868
29Systemic lupus erythematosus_Homo sapiens_hsa053221.15883729
30Glucagon signaling pathway_Homo sapiens_hsa049221.07323489
31Ether lipid metabolism_Homo sapiens_hsa005651.06839925
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.06717352
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03969512
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02990185
35RNA polymerase_Homo sapiens_hsa030201.01463146
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01194067
37Dopaminergic synapse_Homo sapiens_hsa047281.01005280
38Alcoholism_Homo sapiens_hsa050340.99088630
39Nucleotide excision repair_Homo sapiens_hsa034200.97773389
40p53 signaling pathway_Homo sapiens_hsa041150.92857005
41Dorso-ventral axis formation_Homo sapiens_hsa043200.91880532
42Oocyte meiosis_Homo sapiens_hsa041140.91036271
43Selenocompound metabolism_Homo sapiens_hsa004500.90838473
44Morphine addiction_Homo sapiens_hsa050320.90086803
45Circadian entrainment_Homo sapiens_hsa047130.89792574
46Retinol metabolism_Homo sapiens_hsa008300.86373775
47One carbon pool by folate_Homo sapiens_hsa006700.85987841
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85619972
49Cocaine addiction_Homo sapiens_hsa050300.85058740
50Nitrogen metabolism_Homo sapiens_hsa009100.82286731
51Cholinergic synapse_Homo sapiens_hsa047250.81087494
52Type II diabetes mellitus_Homo sapiens_hsa049300.78084711
53Base excision repair_Homo sapiens_hsa034100.77796446
54Cell cycle_Homo sapiens_hsa041100.75985501
55Phototransduction_Homo sapiens_hsa047440.75302361
56AMPK signaling pathway_Homo sapiens_hsa041520.72778746
57Linoleic acid metabolism_Homo sapiens_hsa005910.72108045
58TGF-beta signaling pathway_Homo sapiens_hsa043500.67672383
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67552529
60GABAergic synapse_Homo sapiens_hsa047270.66834490
61Choline metabolism in cancer_Homo sapiens_hsa052310.64802218
62Axon guidance_Homo sapiens_hsa043600.62867556
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61167542
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60937951
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57950882
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57259019
67mTOR signaling pathway_Homo sapiens_hsa041500.57136811
68N-Glycan biosynthesis_Homo sapiens_hsa005100.56428579
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56179484
70FoxO signaling pathway_Homo sapiens_hsa040680.55183644
71Renin secretion_Homo sapiens_hsa049240.54942043
72Tryptophan metabolism_Homo sapiens_hsa003800.52455843
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52319332
74Protein export_Homo sapiens_hsa030600.52260038
75ABC transporters_Homo sapiens_hsa020100.49469674
76Lysine degradation_Homo sapiens_hsa003100.47308496
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46054410
78cAMP signaling pathway_Homo sapiens_hsa040240.45371465
79Melanoma_Homo sapiens_hsa052180.43266487
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42901418
81RNA transport_Homo sapiens_hsa030130.42377404
82Gastric acid secretion_Homo sapiens_hsa049710.42111221
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.41827929
84Insulin resistance_Homo sapiens_hsa049310.41587178
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41036170
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40611128
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35994843
88Calcium signaling pathway_Homo sapiens_hsa040200.35666317
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35062817
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34725880
91ErbB signaling pathway_Homo sapiens_hsa040120.34647048
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33921723
93Serotonergic synapse_Homo sapiens_hsa047260.32135942
94Glycerolipid metabolism_Homo sapiens_hsa005610.31563893
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31447585
96Purine metabolism_Homo sapiens_hsa002300.30691979
97Metabolic pathways_Homo sapiens_hsa011000.29597508
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.29370552
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28600436
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.28282048

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