TAS2R46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of translation, ncRNA-mediated (GO:0040033)6.03590318
2regulation of translation, ncRNA-mediated (GO:0045974)6.03590318
3negative regulation of translation involved in gene silencing by miRNA (GO:0035278)6.03590318
4nephron tubule morphogenesis (GO:0072078)5.80971115
5nephron epithelium morphogenesis (GO:0072088)5.80971115
6prenylation (GO:0097354)5.35663443
7protein prenylation (GO:0018342)5.35663443
8DNA deamination (GO:0045006)5.02585843
9amyloid precursor protein catabolic process (GO:0042987)4.97820136
10beta-amyloid metabolic process (GO:0050435)4.97286377
11* detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.88763217
12regulation of DNA endoreduplication (GO:0032875)4.74758763
13positive regulation of TOR signaling (GO:0032008)4.72872408
14DNA integration (GO:0015074)4.64130166
15nephron tubule formation (GO:0072079)4.45921266
16nuclear pore organization (GO:0006999)4.42696143
17purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)4.40017291
18response to pheromone (GO:0019236)4.39834538
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.39095634
20histone H2A acetylation (GO:0043968)4.29660443
21renal tubule morphogenesis (GO:0061333)4.29520059
22L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.26603761
23ADP metabolic process (GO:0046031)4.19721428
24positive regulation of myoblast differentiation (GO:0045663)4.19592993
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.13612671
26mitochondrial genome maintenance (GO:0000002)4.10712005
27positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc4.05666899
28* detection of chemical stimulus involved in sensory perception of taste (GO:0050912)4.04688099
29negative regulation of cytosolic calcium ion concentration (GO:0051481)4.00516231
30negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.97693530
31protein K11-linked deubiquitination (GO:0035871)3.82449284
32ether lipid metabolic process (GO:0046485)3.77848867
33negative regulation of metanephros development (GO:0072217)3.75576548
34negative regulation of DNA-dependent DNA replication (GO:2000104)3.66416606
35cytidine catabolic process (GO:0006216)3.64606901
36cytidine deamination (GO:0009972)3.64606901
37cytidine metabolic process (GO:0046087)3.64606901
38cellular response to gamma radiation (GO:0071480)3.63823229
39phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.58901601
40amyloid precursor protein metabolic process (GO:0042982)3.57385870
41telomere maintenance via telomerase (GO:0007004)3.52430705
42nucleobase catabolic process (GO:0046113)3.51729213
43myelin assembly (GO:0032288)3.46603213
44proline transport (GO:0015824)3.45463880
45negative regulation of neurological system process (GO:0031645)3.42279578
46atrial cardiac muscle cell action potential (GO:0086014)3.37883846
47microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.37733067
48nuclear pore complex assembly (GO:0051292)3.35967761
49regulation of mitotic spindle checkpoint (GO:1903504)3.34946111
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.34946111
51establishment of protein localization to Golgi (GO:0072600)3.32956240
52positive regulation of mitochondrial fission (GO:0090141)3.32394241
53regulation of sarcomere organization (GO:0060297)3.30692382
54inositol phosphate-mediated signaling (GO:0048016)3.29502024
55L-methionine salvage (GO:0071267)3.26069971
56L-methionine biosynthetic process (GO:0071265)3.26069971
57amino acid salvage (GO:0043102)3.26069971
58cellular response to ethanol (GO:0071361)3.24483590
59positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.23863900
60detection of calcium ion (GO:0005513)3.22121413
61positive regulation of DNA-templated transcription, initiation (GO:2000144)3.20599105
62pyrimidine ribonucleoside catabolic process (GO:0046133)3.20368535
63valine metabolic process (GO:0006573)3.16998093
64mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.15465755
65protein targeting to Golgi (GO:0000042)3.14403793
66regulation of mesenchymal cell apoptotic process (GO:2001053)3.09606234
67sister chromatid cohesion (GO:0007062)3.05404636
68spindle assembly involved in mitosis (GO:0090307)3.02573055
69myeloid cell homeostasis (GO:0002262)3.00737793
70retrograde transport, vesicle recycling within Golgi (GO:0000301)2.98632568
71multicellular organismal movement (GO:0050879)2.98061145
72musculoskeletal movement (GO:0050881)2.98061145
73regulation of cell communication by electrical coupling (GO:0010649)2.96465938
74DNA dealkylation (GO:0035510)2.94220514
75hindbrain development (GO:0030902)2.93904005
76regulation of transforming growth factor beta2 production (GO:0032909)2.93516193
77acrosome assembly (GO:0001675)2.93322976
78righting reflex (GO:0060013)2.90440119
79regulation of telomere maintenance (GO:0032204)2.88681298
80synapsis (GO:0007129)2.84232667
81regulation of alkaline phosphatase activity (GO:0010692)2.80019402
82RNA-dependent DNA replication (GO:0006278)2.79237348
83vascular smooth muscle contraction (GO:0014829)2.78268014
84response to UV-C (GO:0010225)2.78156500
85phosphorylated carbohydrate dephosphorylation (GO:0046838)2.77038794
86inositol phosphate dephosphorylation (GO:0046855)2.77038794
87negative regulation of meiosis (GO:0045835)2.76133107
88methionine biosynthetic process (GO:0009086)2.75006188
89protein neddylation (GO:0045116)2.73051434
90embryonic epithelial tube formation (GO:0001838)2.72243763
91eating behavior (GO:0042755)2.68297035
92detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.67893135
93pericardium development (GO:0060039)2.67590380
94DNA demethylation (GO:0080111)2.67418427
95non-recombinational repair (GO:0000726)2.64442742
96double-strand break repair via nonhomologous end joining (GO:0006303)2.64442742
97deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.62444804
98membrane protein ectodomain proteolysis (GO:0006509)2.61417773
99regulation of ARF protein signal transduction (GO:0032012)2.59065536
100reflex (GO:0060004)2.58572077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.30366227
2POU3F2_20337985_ChIP-ChIP_501MEL_Human3.13163982
3TAF15_26573619_Chip-Seq_HEK293_Human2.68184093
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.65584249
5EWS_26573619_Chip-Seq_HEK293_Human2.57003457
6FUS_26573619_Chip-Seq_HEK293_Human2.55531990
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54230050
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.52334045
9GBX2_23144817_ChIP-Seq_PC3_Human2.45517614
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.36519746
11SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.36352299
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.34932224
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.32797118
14ZNF274_21170338_ChIP-Seq_K562_Hela2.30655784
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.22932957
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08514066
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07145383
18PIAS1_25552417_ChIP-Seq_VCAP_Human2.00555851
19P300_19829295_ChIP-Seq_ESCs_Human2.00399659
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97875514
21SMAD4_21799915_ChIP-Seq_A2780_Human1.95690224
22ELK1_19687146_ChIP-ChIP_HELA_Human1.87517715
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81611513
24NANOG_18555785_Chip-Seq_ESCs_Mouse1.78185196
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76349582
26TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.74295569
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.73356570
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72310844
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72096347
30FOXA1_21572438_ChIP-Seq_LNCaP_Human1.65712074
31SMAD3_21741376_ChIP-Seq_EPCs_Human1.64880852
32STAT3_23295773_ChIP-Seq_U87_Human1.64723734
33TCF4_23295773_ChIP-Seq_U87_Human1.64403123
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62546768
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62290664
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.61142465
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59872357
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55930013
39AR_25329375_ChIP-Seq_VCAP_Human1.54117782
40IGF1R_20145208_ChIP-Seq_DFB_Human1.54078073
41CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.49407243
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49237166
43TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.49105350
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.48521917
45SUZ12_18555785_Chip-Seq_ESCs_Mouse1.46181102
46KLF5_20875108_ChIP-Seq_MESCs_Mouse1.46075266
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45941306
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45941306
49E2F1_18555785_Chip-Seq_ESCs_Mouse1.45732385
50OCT4_21477851_ChIP-Seq_ESCs_Mouse1.43769369
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43008472
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42121181
53CMYC_18555785_Chip-Seq_ESCs_Mouse1.41740574
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41162357
55CBP_20019798_ChIP-Seq_JUKART_Human1.39887557
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39887557
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39814358
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.37306746
59BCAT_22108803_ChIP-Seq_LS180_Human1.35821815
60P53_22387025_ChIP-Seq_ESCs_Mouse1.35403530
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34026653
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.33512359
63SOX2_18555785_Chip-Seq_ESCs_Mouse1.32739101
64TCF4_22108803_ChIP-Seq_LS180_Human1.32324815
65CRX_20693478_ChIP-Seq_RETINA_Mouse1.29537209
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27709268
67AHR_22903824_ChIP-Seq_MCF-7_Human1.26505094
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.26251006
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25405035
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.24655798
71P300_18555785_Chip-Seq_ESCs_Mouse1.24285826
72CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.24003410
73GATA1_22025678_ChIP-Seq_K562_Human1.23692488
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23096033
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21216780
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20100456
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20100456
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18782603
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17416640
80SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16753148
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16577433
82ZFX_18555785_Chip-Seq_ESCs_Mouse1.16240948
83FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16011568
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15077560
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.13203808
86NMYC_18555785_Chip-Seq_ESCs_Mouse1.13038420
87OCT4_18555785_Chip-Seq_ESCs_Mouse1.12812154
88SMAD3_21741376_ChIP-Seq_HESCs_Human1.12543413
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.12501446
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11790021
91CDX2_22108803_ChIP-Seq_LS180_Human1.11449145
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09818580
93TP53_22573176_ChIP-Seq_HFKS_Human1.09575164
94ER_23166858_ChIP-Seq_MCF-7_Human1.08112759
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06755315
96TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06382569
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06122439
98RUNX2_22187159_ChIP-Seq_PCA_Human1.06115103
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.05250638
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03146499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.50651007
2MP0002138_abnormal_hepatobiliary_system6.97106640
3MP0003183_abnormal_peptide_metabolism5.40582894
4MP0000013_abnormal_adipose_tissue4.57802785
5MP0009780_abnormal_chondrocyte_physiolo4.16931769
6MP0002837_dystrophic_cardiac_calcinosis4.01192124
7MP0005645_abnormal_hypothalamus_physiol3.68052716
8MP0005084_abnormal_gallbladder_morpholo3.35580896
9MP0004043_abnormal_pH_regulation2.77658983
10MP0004185_abnormal_adipocyte_glucose2.42106089
11MP0003045_fibrosis2.29024806
12MP0009046_muscle_twitch2.10824379
13MP0005075_abnormal_melanosome_morpholog1.96561505
14MP0002928_abnormal_bile_duct1.96104123
15MP0005083_abnormal_biliary_tract1.92554640
16MP0003890_abnormal_embryonic-extraembry1.78217191
17MP0006054_spinal_hemorrhage1.75016094
18MP0008961_abnormal_basal_metabolism1.73647999
19MP0003950_abnormal_plasma_membrane1.63752399
20MP0000569_abnormal_digit_pigmentation1.60254240
21MP0001968_abnormal_touch/_nociception1.60024540
22MP0000372_irregular_coat_pigmentation1.50738496
23MP0002102_abnormal_ear_morphology1.49815755
24MP0000003_abnormal_adipose_tissue1.41211995
25MP0004084_abnormal_cardiac_muscle1.41003110
26MP0004145_abnormal_muscle_electrophysio1.32356737
27MP0001486_abnormal_startle_reflex1.27109886
28MP0004215_abnormal_myocardial_fiber1.18785863
29MP0000647_abnormal_sebaceous_gland1.18476063
30MP0005551_abnormal_eye_electrophysiolog1.15819029
31MP0002909_abnormal_adrenal_gland1.12776851
32MP0005253_abnormal_eye_physiology1.07603624
33MP0008057_abnormal_DNA_replication1.06460929
34MP0005423_abnormal_somatic_nervous1.02270790
35MP0000747_muscle_weakness1.00929954
36MP0004484_altered_response_of0.98557715
37MP0001529_abnormal_vocalization0.96783062
38MP0002269_muscular_atrophy0.95109803
39MP0003011_delayed_dark_adaptation0.92617078
40MP0002396_abnormal_hematopoietic_system0.92562328
41MP0004808_abnormal_hematopoietic_stem0.91187919
42MP0000462_abnormal_digestive_system0.89062555
43MP0002168_other_aberrant_phenotype0.89003596
44MP0005375_adipose_tissue_phenotype0.87282361
45MP0002163_abnormal_gland_morphology0.86815339
46MP0004742_abnormal_vestibular_system0.85574416
47MP0002638_abnormal_pupillary_reflex0.84210566
48MP0010329_abnormal_lipoprotein_level0.84100953
49MP0008007_abnormal_cellular_replicative0.83826746
50MP0003221_abnormal_cardiomyocyte_apopto0.82732469
51MP0002938_white_spotting0.80536624
52MP0003137_abnormal_impulse_conducting0.79091713
53MP0005386_behavior/neurological_phenoty0.78979065
54MP0004924_abnormal_behavior0.78979065
55MP0004270_analgesia0.74316863
56MP0000371_diluted_coat_color0.73776076
57MP0002067_abnormal_sensory_capabilities0.73337986
58MP0002272_abnormal_nervous_system0.72466481
59MP0004134_abnormal_chest_morphology0.71074588
60MP0005395_other_phenotype0.70443128
61MP0002009_preneoplasia0.69833963
62MP0010234_abnormal_vibrissa_follicle0.69209870
63MP0001270_distended_abdomen0.69122657
64MP0008058_abnormal_DNA_repair0.68053560
65MP0003880_abnormal_central_pattern0.67905308
66MP0004085_abnormal_heartbeat0.67677940
67MP0005379_endocrine/exocrine_gland_phen0.67449671
68MP0000749_muscle_degeneration0.66652498
69MP0002160_abnormal_reproductive_system0.66487457
70MP0001661_extended_life_span0.66149751
71MP0000230_abnormal_systemic_arterial0.64267865
72MP0005620_abnormal_muscle_contractility0.61450162
73MP0002734_abnormal_mechanical_nocicepti0.60833791
74MP0004142_abnormal_muscle_tone0.60736559
75MP0000383_abnormal_hair_follicle0.60583960
76MP0010678_abnormal_skin_adnexa0.60149640
77MP0005389_reproductive_system_phenotype0.60037700
78MP0003077_abnormal_cell_cycle0.59352932
79MP0010386_abnormal_urinary_bladder0.57981840
80MP0005410_abnormal_fertilization0.57218389
81MP0003172_abnormal_lysosome_physiology0.57087045
82MP0004036_abnormal_muscle_relaxation0.56566946
83MP0006035_abnormal_mitochondrial_morpho0.56183812
84MP0005266_abnormal_metabolism0.53524164
85MP0009745_abnormal_behavioral_response0.52629160
86MP0003385_abnormal_body_wall0.52175678
87MP0003718_maternal_effect0.50297947
88MP0005248_abnormal_Harderian_gland0.50250987
89MP0001986_abnormal_taste_sensitivity0.50155362
90MP0004264_abnormal_extraembryonic_tissu0.49612264
91MP0002127_abnormal_cardiovascular_syste0.48618150
92MP0003567_abnormal_fetal_cardiomyocyte0.48578194
93MP0003195_calcinosis0.47607619
94MP0005666_abnormal_adipose_tissue0.47522548
95MP0002876_abnormal_thyroid_physiology0.47344865
96MP0000015_abnormal_ear_pigmentation0.46792310
97MP0003868_abnormal_feces_composition0.46011671
98MP0001286_abnormal_eye_development0.45099044
99MP0003879_abnormal_hair_cell0.44795396
100MP0001984_abnormal_olfaction0.44741198

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pancreas size (HP:0012094)5.91090286
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.56315157
3Glucose intolerance (HP:0000833)4.13191881
4Exertional dyspnea (HP:0002875)4.08958373
5Chromsome breakage (HP:0040012)4.07768075
6Gout (HP:0001997)3.83163179
7Methylmalonic acidemia (HP:0002912)3.79167225
8Unilateral renal agenesis (HP:0000122)3.77077841
9Thoracolumbar scoliosis (HP:0002944)3.71602664
10Microvesicular hepatic steatosis (HP:0001414)3.66513797
11Postural tremor (HP:0002174)3.65363335
12Hypoplasia of the uterus (HP:0000013)3.64387737
13Intestinal atresia (HP:0011100)3.59880978
14Tubulointerstitial nephritis (HP:0001970)3.37736079
15Fatigue (HP:0012378)3.34016057
16Broad-based gait (HP:0002136)3.25989480
17Action tremor (HP:0002345)3.16799229
18Abnormal glucose tolerance (HP:0001952)3.16392761
19Aplasia/hypoplasia of the uterus (HP:0008684)3.07872810
20Visual hallucinations (HP:0002367)3.04842040
21Duplicated collecting system (HP:0000081)3.04195047
22Abnormality of chromosome stability (HP:0003220)2.92901119
23Amyotrophic lateral sclerosis (HP:0007354)2.83316533
24Gaze-evoked nystagmus (HP:0000640)2.79941386
25Exercise-induced muscle cramps (HP:0003710)2.79517056
26Abnormality of vitamin B metabolism (HP:0004340)2.78888323
27Glycosuria (HP:0003076)2.78146148
28Abnormality of urine glucose concentration (HP:0011016)2.78146148
29Methylmalonic aciduria (HP:0012120)2.76654356
30Increased hepatocellular lipid droplets (HP:0006565)2.76451044
31Dialeptic seizures (HP:0011146)2.71042923
32Abnormality of the renal collecting system (HP:0004742)2.70326460
33Distal arthrogryposis (HP:0005684)2.66629855
34Broad alveolar ridges (HP:0000187)2.63905508
35Irregular vertebral endplates (HP:0003301)2.62552730
36Vitreoretinal degeneration (HP:0000655)2.60732157
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.58960889
38Lipid accumulation in hepatocytes (HP:0006561)2.48540107
39Frequent falls (HP:0002359)2.47685655
40Pancreatic cysts (HP:0001737)2.47005245
41Meckel diverticulum (HP:0002245)2.41621956
42Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.40994341
43Myocardial infarction (HP:0001658)2.39296343
44Neoplasm of the oral cavity (HP:0100649)2.36803511
45Dysdiadochokinesis (HP:0002075)2.35958073
46Abnormality of the ileum (HP:0001549)2.34013011
47Adactyly (HP:0009776)2.32832464
48Ureteral duplication (HP:0000073)2.29362056
49Bony spicule pigmentary retinopathy (HP:0007737)2.27904708
50Scanning speech (HP:0002168)2.24084582
51Renal cortical cysts (HP:0000803)2.22938409
52Absence seizures (HP:0002121)2.22126380
53Medulloblastoma (HP:0002885)2.21473914
54Abnormality of the renal cortex (HP:0011035)2.19384058
55Posterior subcapsular cataract (HP:0007787)2.19036560
56Hypobetalipoproteinemia (HP:0003563)2.18824757
57Chin dimple (HP:0010751)2.17919787
58Late onset (HP:0003584)2.17564358
59Abnormality of the vitamin B12 metabolism (HP:0004341)2.15484281
60Cerebral hemorrhage (HP:0001342)2.14779275
61Clubbing of toes (HP:0100760)2.13392772
62Progressive muscle weakness (HP:0003323)2.12998591
63Abnormal biliary tract morphology (HP:0012440)2.10344951
64Fair hair (HP:0002286)2.07954747
65Heterotopia (HP:0002282)2.07388836
66IgM deficiency (HP:0002850)2.07169890
67Cerebellar dysplasia (HP:0007033)2.05960539
68Abnormality of DNA repair (HP:0003254)2.04727047
69Aplasia/Hypoplasia of the hallux (HP:0008362)2.04296788
70Acute hepatic failure (HP:0006554)2.03648500
71Supernumerary spleens (HP:0009799)2.02523790
72Congenital malformation of the right heart (HP:0011723)1.99348133
73Double outlet right ventricle (HP:0001719)1.99348133
74Bifid tongue (HP:0010297)1.98026631
75Molar tooth sign on MRI (HP:0002419)1.96424836
76Abnormality of midbrain morphology (HP:0002418)1.96424836
77Increased purine levels (HP:0004368)1.95087210
78Hyperuricemia (HP:0002149)1.95087210
79Neoplasm of the adrenal cortex (HP:0100641)1.94206320
80Impaired vibration sensation in the lower limbs (HP:0002166)1.93705959
81Albinism (HP:0001022)1.91579885
82Tubulointerstitial abnormality (HP:0001969)1.91081936
83Dysmetric saccades (HP:0000641)1.88697375
84Attenuation of retinal blood vessels (HP:0007843)1.88229522
85Abnormality of the carotid arteries (HP:0005344)1.87126383
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86312423
87Scotoma (HP:0000575)1.85002736
88Abnormality of the preputium (HP:0100587)1.84844511
89Impaired vibratory sensation (HP:0002495)1.84393440
90Bicornuate uterus (HP:0000813)1.84341290
91Abnormality of the vertebral endplates (HP:0005106)1.83937838
92Exocrine pancreatic insufficiency (HP:0001738)1.82372847
93Thyroid-stimulating hormone excess (HP:0002925)1.81817908
942-3 toe syndactyly (HP:0004691)1.77840165
95Type 2 muscle fiber atrophy (HP:0003554)1.77701976
96Glioma (HP:0009733)1.73899245
97Polycythemia (HP:0001901)1.73356525
98Reticulocytopenia (HP:0001896)1.72779864
99Sensorimotor neuropathy (HP:0007141)1.72724216
100Increased corneal curvature (HP:0100692)1.72465587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K44.04006927
2MAP3K63.98936711
3FRK3.50705549
4MARK33.27747109
5TLK13.17785310
6ACVR1B3.10833140
7ZAK2.72548288
8ZAP702.68774114
9MUSK2.68679696
10KSR12.58106183
11BRD42.24801347
12MAP2K32.11376943
13MAP2K42.07917410
14MAP4K21.96177265
15WNK41.95069049
16BMPR1B1.82440375
17MAP2K61.80944150
18STK241.72929382
19PLK21.72188767
20PRKCI1.69496172
21NEK11.68134014
22CASK1.65006927
23EIF2AK31.58463528
24NTRK31.54947491
25MINK11.53888251
26FLT31.53156185
27MAP3K51.50492755
28MAP3K121.49100893
29MST41.47752817
30PIM11.33892494
31WEE11.29731580
32TNIK1.27288095
33WNK31.24926756
34STK111.09147587
35TRIM281.05408756
36OBSCN0.98952479
37DAPK20.97008419
38STK390.95805322
39PTK2B0.95736621
40BCR0.95129423
41MAPK130.93236638
42FER0.90599670
43OXSR10.90440808
44PRKCE0.89091753
45MARK10.86996331
46SGK10.86474694
47WNK10.80835877
48PDK20.77875356
49INSRR0.70984946
50NLK0.69396696
51STK38L0.66779821
52BRSK20.66579134
53PKN20.66070923
54SGK20.64904231
55VRK10.64096847
56CAMK40.63911418
57ADRBK20.63661007
58AKT20.63447392
59MAP3K20.63156238
60NUAK10.62222080
61CSF1R0.61901340
62RET0.60415792
63SYK0.59386645
64IRAK10.57139341
65CSNK1G10.53240640
66PDK10.53051815
67PRKCZ0.52672830
68MAPK70.52379991
69CSNK1G20.50927739
70ADRBK10.50649979
71AKT30.49437852
72IGF1R0.46477556
73TGFBR10.45619325
74FGFR10.44997818
75PNCK0.44409963
76CSNK1D0.44171372
77MELK0.40890084
78NEK60.38407092
79SRPK10.38355502
80MET0.37331220
81CSNK1A1L0.37138733
82RPS6KA50.36632109
83CSNK1G30.35770845
84CAMK1D0.34494726
85PLK10.34491259
86FGFR30.33495122
87SGK2230.32079905
88SGK4940.32079905
89RPS6KB10.31206517
90TEC0.28143611
91BLK0.27661115
92CSNK1E0.27401551
93CAMK2A0.27089359
94ATM0.26756720
95PAK30.26538048
96PIK3CG0.26042746
97LCK0.25992457
98PDPK10.25938798
99GRK10.25608108
100CAMK2D0.25546645

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009206.20691023
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.53308318
3Selenocompound metabolism_Homo sapiens_hsa004503.44393889
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.01180695
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.93308330
6Propanoate metabolism_Homo sapiens_hsa006402.84520381
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.75471397
8* Taste transduction_Homo sapiens_hsa047422.47531134
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34980146
10Non-homologous end-joining_Homo sapiens_hsa034502.14116386
11Fanconi anemia pathway_Homo sapiens_hsa034602.11151042
12Homologous recombination_Homo sapiens_hsa034402.07062082
13Butanoate metabolism_Homo sapiens_hsa006501.97706808
14Systemic lupus erythematosus_Homo sapiens_hsa053221.86960957
15Steroid biosynthesis_Homo sapiens_hsa001001.68506288
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68248759
17Alcoholism_Homo sapiens_hsa050341.63435259
18RNA degradation_Homo sapiens_hsa030181.61728635
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58041184
20Arginine biosynthesis_Homo sapiens_hsa002201.51277275
21Nitrogen metabolism_Homo sapiens_hsa009101.32511803
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26153510
23Glutamatergic synapse_Homo sapiens_hsa047241.26032369
24One carbon pool by folate_Homo sapiens_hsa006701.23767370
25Dopaminergic synapse_Homo sapiens_hsa047281.21492027
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.20234572
27Long-term depression_Homo sapiens_hsa047301.20146333
28Phototransduction_Homo sapiens_hsa047441.18705586
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17408713
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16734124
31Fatty acid elongation_Homo sapiens_hsa000621.13435465
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09979426
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.05114276
34GABAergic synapse_Homo sapiens_hsa047271.04116830
35Circadian entrainment_Homo sapiens_hsa047131.02701905
36Circadian rhythm_Homo sapiens_hsa047101.00612399
37Renin secretion_Homo sapiens_hsa049240.98402615
38Vascular smooth muscle contraction_Homo sapiens_hsa042700.97239959
39Nicotine addiction_Homo sapiens_hsa050330.96432996
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.94887849
41Purine metabolism_Homo sapiens_hsa002300.91017069
42Folate biosynthesis_Homo sapiens_hsa007900.89736832
43Serotonergic synapse_Homo sapiens_hsa047260.85986211
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84122160
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82231387
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81165503
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81100456
48Alzheimers disease_Homo sapiens_hsa050100.77603589
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76705933
50Salivary secretion_Homo sapiens_hsa049700.73878448
51Mismatch repair_Homo sapiens_hsa034300.70894602
52Peroxisome_Homo sapiens_hsa041460.69935364
53Morphine addiction_Homo sapiens_hsa050320.67431195
54Basal transcription factors_Homo sapiens_hsa030220.67248941
55Calcium signaling pathway_Homo sapiens_hsa040200.61840425
56Inositol phosphate metabolism_Homo sapiens_hsa005620.61211148
57Tyrosine metabolism_Homo sapiens_hsa003500.57777798
58Olfactory transduction_Homo sapiens_hsa047400.57217870
59Retinol metabolism_Homo sapiens_hsa008300.57176553
60Choline metabolism in cancer_Homo sapiens_hsa052310.57090859
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56381198
62GnRH signaling pathway_Homo sapiens_hsa049120.56205188
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55894872
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54958167
65RNA transport_Homo sapiens_hsa030130.54737881
66Renin-angiotensin system_Homo sapiens_hsa046140.52970210
67mTOR signaling pathway_Homo sapiens_hsa041500.51272677
68TGF-beta signaling pathway_Homo sapiens_hsa043500.50757042
69Nucleotide excision repair_Homo sapiens_hsa034200.50300455
70Base excision repair_Homo sapiens_hsa034100.50045794
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49189584
72Adherens junction_Homo sapiens_hsa045200.48448517
73Oxidative phosphorylation_Homo sapiens_hsa001900.48200389
74beta-Alanine metabolism_Homo sapiens_hsa004100.47423254
75Fatty acid metabolism_Homo sapiens_hsa012120.46510165
76Glucagon signaling pathway_Homo sapiens_hsa049220.45854486
77Insulin secretion_Homo sapiens_hsa049110.45181244
78RNA polymerase_Homo sapiens_hsa030200.44009201
79Viral carcinogenesis_Homo sapiens_hsa052030.42473641
80Metabolic pathways_Homo sapiens_hsa011000.40114984
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38172877
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36421273
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.36142809
84Pancreatic secretion_Homo sapiens_hsa049720.35828578
85Ether lipid metabolism_Homo sapiens_hsa005650.35715424
86p53 signaling pathway_Homo sapiens_hsa041150.34544016
87Gap junction_Homo sapiens_hsa045400.33683674
88Basal cell carcinoma_Homo sapiens_hsa052170.32989090
89Linoleic acid metabolism_Homo sapiens_hsa005910.32842969
90Notch signaling pathway_Homo sapiens_hsa043300.32412954
91Colorectal cancer_Homo sapiens_hsa052100.32065698
92Fatty acid biosynthesis_Homo sapiens_hsa000610.30866398
93Cholinergic synapse_Homo sapiens_hsa047250.29770907
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28636220
95Type I diabetes mellitus_Homo sapiens_hsa049400.28296494
96Vitamin B6 metabolism_Homo sapiens_hsa007500.28111772
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26358704
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.25927991
99Ovarian steroidogenesis_Homo sapiens_hsa049130.24959415
100Protein export_Homo sapiens_hsa030600.24945720

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