TAS2R5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial DNA metabolic process (GO:0032042)5.61372576
2definitive hemopoiesis (GO:0060216)5.51378396
3mitochondrial DNA replication (GO:0006264)5.48808934
4formation of translation preinitiation complex (GO:0001731)5.07153621
5negative regulation of gluconeogenesis (GO:0045721)4.99792782
6DNA unwinding involved in DNA replication (GO:0006268)4.73033913
7positive regulation of glycolytic process (GO:0045821)4.64136890
8DNA strand elongation involved in DNA replication (GO:0006271)4.45005041
9purine deoxyribonucleotide catabolic process (GO:0009155)4.34047646
10DNA strand elongation (GO:0022616)4.29858272
11poly(A)+ mRNA export from nucleus (GO:0016973)4.26714281
12protein K11-linked deubiquitination (GO:0035871)4.21711466
13fatty acid homeostasis (GO:0055089)4.08745957
14protein prenylation (GO:0018342)4.08560076
15prenylation (GO:0097354)4.08560076
16histamine secretion (GO:0001821)4.04224442
17mitotic G2 DNA damage checkpoint (GO:0007095)4.03174531
18DNA replication initiation (GO:0006270)4.01550201
19positive regulation of histone H3-K4 methylation (GO:0051571)4.00410365
20nuclear pore complex assembly (GO:0051292)3.93601990
21positive regulation of granulocyte differentiation (GO:0030854)3.92779826
22positive regulation of insulin receptor signaling pathway (GO:0046628)3.92338929
23histone H3-K9 methylation (GO:0051567)3.86479041
24embryonic retina morphogenesis in camera-type eye (GO:0060059)3.86382712
25mitotic G2/M transition checkpoint (GO:0044818)3.85919326
26histone H3-K9 modification (GO:0061647)3.75975757
27regulation of histone H3-K9 methylation (GO:0051570)3.72624550
28telomere maintenance via semi-conservative replication (GO:0032201)3.67812373
29intra-S DNA damage checkpoint (GO:0031573)3.66010174
30retinal rod cell development (GO:0046548)3.60330948
31nucleotide-excision repair, DNA gap filling (GO:0006297)3.58958543
32dosage compensation (GO:0007549)3.44546657
33purine deoxyribonucleotide metabolic process (GO:0009151)3.44432196
34histamine transport (GO:0051608)3.41675775
35mismatch repair (GO:0006298)3.38827515
36mitotic recombination (GO:0006312)3.35216352
37DNA-dependent DNA replication (GO:0006261)3.34767610
38nuclear pore organization (GO:0006999)3.33094604
39telomere maintenance via recombination (GO:0000722)3.30917140
40RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.29353111
41regulation of histone H3-K4 methylation (GO:0051569)3.28256029
42tRNA aminoacylation for protein translation (GO:0006418)3.17125050
43eye photoreceptor cell differentiation (GO:0001754)3.17115254
44photoreceptor cell differentiation (GO:0046530)3.17115254
45DNA topological change (GO:0006265)3.12861182
46tRNA aminoacylation (GO:0043039)3.11404981
47amino acid activation (GO:0043038)3.11404981
48genitalia morphogenesis (GO:0035112)3.10293498
49histone H2A acetylation (GO:0043968)3.09228306
50regulation of Golgi to plasma membrane protein transport (GO:0042996)3.06498272
51positive regulation of RNA splicing (GO:0033120)3.04156049
52organelle membrane fusion (GO:0090174)3.02534068
53water-soluble vitamin biosynthetic process (GO:0042364)3.02147936
54carbohydrate phosphorylation (GO:0046835)3.02028838
55cellular response to leptin stimulus (GO:0044320)3.01276195
56forebrain morphogenesis (GO:0048853)2.98847367
57somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.98493636
58isotype switching (GO:0045190)2.98493636
59somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.98493636
60positive regulation of growth hormone secretion (GO:0060124)2.96759626
61branched-chain amino acid catabolic process (GO:0009083)2.96629063
62photoreceptor cell maintenance (GO:0045494)2.96434495
63DNA ligation (GO:0006266)2.95982335
64deoxyribonucleotide catabolic process (GO:0009264)2.95488627
65intestinal cholesterol absorption (GO:0030299)2.95253408
66DNA duplex unwinding (GO:0032508)2.93143482
67regulation of growth hormone secretion (GO:0060123)2.92183242
68nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.89857359
69deoxyribose phosphate catabolic process (GO:0046386)2.88524154
70DNA geometric change (GO:0032392)2.86768448
71regulation of type B pancreatic cell apoptotic process (GO:2000674)2.86736693
72proline biosynthetic process (GO:0006561)2.83996016
73base-excision repair (GO:0006284)2.83713077
74male sex determination (GO:0030238)2.83587315
75peptidyl-lysine trimethylation (GO:0018023)2.83193701
76regulation of centriole replication (GO:0046599)2.83072175
77IMP biosynthetic process (GO:0006188)2.79920489
78telomere maintenance via telomere lengthening (GO:0010833)2.77830644
79replication fork processing (GO:0031297)2.77393634
80negative regulation of DNA recombination (GO:0045910)2.76060765
81DNA synthesis involved in DNA repair (GO:0000731)2.74231514
82response to UV-B (GO:0010224)2.73840083
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72131342
84mitotic sister chromatid cohesion (GO:0007064)2.70810462
85valine metabolic process (GO:0006573)2.70582315
86megakaryocyte development (GO:0035855)2.67411597
87nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.65851325
88DNA strand renaturation (GO:0000733)2.64492815
89non-recombinational repair (GO:0000726)2.64444437
90double-strand break repair via nonhomologous end joining (GO:0006303)2.64444437
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.62833523
92peptidyl-threonine dephosphorylation (GO:0035970)2.62464320
93translesion synthesis (GO:0019985)2.62250225
94somatic recombination of immunoglobulin gene segments (GO:0016447)2.61434836
95protein targeting to vacuole (GO:0006623)2.60250236
96protein targeting to lysosome (GO:0006622)2.60250236
97establishment of protein localization to vacuole (GO:0072666)2.60250236
98positive regulation of glycogen biosynthetic process (GO:0045725)2.60046342
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.59682754
100mitotic DNA integrity checkpoint (GO:0044774)2.57967076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.34150926
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.81657177
3GATA1_22025678_ChIP-Seq_K562_Human5.49740266
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.54945672
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.26473134
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.91075919
7IGF1R_20145208_ChIP-Seq_DFB_Human2.76018724
8PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.73843615
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.72471751
10ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.49887032
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35839902
12TAF15_26573619_Chip-Seq_HEK293_Human2.31904959
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.31631693
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23816988
15ELK1_19687146_ChIP-ChIP_HELA_Human2.10425649
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03547341
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.01718162
18YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99791215
19FUS_26573619_Chip-Seq_HEK293_Human1.96438113
20DCP1A_22483619_ChIP-Seq_HELA_Human1.93683774
21FOXP3_21729870_ChIP-Seq_TREG_Human1.93460534
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93346058
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.84025209
24VDR_23849224_ChIP-Seq_CD4+_Human1.75174730
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.72533179
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69683746
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66939796
28EWS_26573619_Chip-Seq_HEK293_Human1.62407225
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56627800
30ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56454421
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.55784593
32TTF2_22483619_ChIP-Seq_HELA_Human1.55568463
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54512138
34SCL_19346495_ChIP-Seq_HPC-7_Human1.54184449
35GBX2_23144817_ChIP-Seq_PC3_Human1.46346571
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44347757
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.44067367
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43593623
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43416257
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42895343
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41949580
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32507776
43GABP_19822575_ChIP-Seq_HepG2_Human1.29879290
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.27471666
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27073073
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25739040
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25627642
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24710145
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24332363
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.22710143
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.22218098
52KDM5A_27292631_Chip-Seq_BREAST_Human1.21273402
53VDR_22108803_ChIP-Seq_LS180_Human1.20263608
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20133394
55CIITA_25753668_ChIP-Seq_RAJI_Human1.18768267
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18141906
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17953169
58MYB_26560356_Chip-Seq_TH2_Human1.16321330
59XRN2_22483619_ChIP-Seq_HELA_Human1.15954592
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15520957
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15420612
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15414468
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.11673071
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11276206
65CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10813959
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09962189
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09093189
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06221805
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05721577
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03742131
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02432003
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00329275
73AR_21909140_ChIP-Seq_LNCAP_Human1.00115977
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97960500
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95934500
76E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95500583
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94276138
78GATA2_19941826_ChIP-Seq_K562_Human0.93047205
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92226295
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91561705
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88347474
82AR_21572438_ChIP-Seq_LNCaP_Human0.87825193
83NCOR1_26117541_ChIP-Seq_K562_Human0.87588660
84CBP_20019798_ChIP-Seq_JUKART_Human0.87419355
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87419355
86* STAT3_23295773_ChIP-Seq_U87_Human0.85365171
87PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85166664
88REST_19997604_ChIP-ChIP_NEURONS_Mouse0.84993986
89CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84099830
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.84008180
91IRF1_19129219_ChIP-ChIP_H3396_Human0.83504735
92ZNF274_21170338_ChIP-Seq_K562_Hela0.82333442
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82169072
94FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78355370
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77205877
96WDR5_24793694_ChIP-Seq_LNCAP_Human0.75335425
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75202389
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.74803988
99FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.74719974
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74338184

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.18048001
2MP0010094_abnormal_chromosome_stability3.52998610
3MP0008057_abnormal_DNA_replication3.27361385
4MP0003122_maternal_imprinting3.19906596
5MP0010352_gastrointestinal_tract_polyps3.18044996
6MP0003567_abnormal_fetal_cardiomyocyte3.10014424
7MP0004147_increased_porphyrin_level2.81350352
8MP0001529_abnormal_vocalization2.75470497
9MP0009697_abnormal_copulation2.65539521
10MP0003252_abnormal_bile_duct2.51852081
11MP0003656_abnormal_erythrocyte_physiolo2.48261386
12MP0002396_abnormal_hematopoietic_system2.46964562
13MP0010234_abnormal_vibrissa_follicle2.39722557
14MP0003111_abnormal_nucleus_morphology2.39526511
15MP0002009_preneoplasia2.33225927
16MP0006292_abnormal_olfactory_placode2.30983298
17MP0001984_abnormal_olfaction2.24846806
18MP0003077_abnormal_cell_cycle2.20419159
19MP0010307_abnormal_tumor_latency2.19824688
20MP0004808_abnormal_hematopoietic_stem1.90287363
21MP0003943_abnormal_hepatobiliary_system1.87292673
22MP0001764_abnormal_homeostasis1.82859092
23MP0003195_calcinosis1.76551078
24MP0003890_abnormal_embryonic-extraembry1.74221861
25MP0004957_abnormal_blastocyst_morpholog1.66750399
26MP0008260_abnormal_autophagy1.64572667
27MP0003283_abnormal_digestive_organ1.64418846
28MP0000013_abnormal_adipose_tissue1.58944097
29MP0001730_embryonic_growth_arrest1.57782375
30MP0008007_abnormal_cellular_replicative1.52562480
31MP0002928_abnormal_bile_duct1.51278570
32MP0003984_embryonic_growth_retardation1.49675690
33MP0002088_abnormal_embryonic_growth/wei1.47608788
34MP0000350_abnormal_cell_proliferation1.47173748
35MP0006035_abnormal_mitochondrial_morpho1.46753550
36MP0005220_abnormal_exocrine_pancreas1.44981039
37MP0000003_abnormal_adipose_tissue1.40869072
38MP0003221_abnormal_cardiomyocyte_apopto1.37861736
39MP0005380_embryogenesis_phenotype1.37818316
40MP0001672_abnormal_embryogenesis/_devel1.37818316
41MP0003121_genomic_imprinting1.36745829
42MP0003693_abnormal_embryo_hatching1.35792773
43MP0001697_abnormal_embryo_size1.33842113
44MP0002132_abnormal_respiratory_system1.31075865
45MP0004264_abnormal_extraembryonic_tissu1.25704998
46MP0002086_abnormal_extraembryonic_tissu1.22752124
47MP0010329_abnormal_lipoprotein_level1.20517535
48MP0003172_abnormal_lysosome_physiology1.18079940
49MP0009703_decreased_birth_body1.17057734
50MP0002971_abnormal_brown_adipose1.12177437
51MP0000427_abnormal_hair_cycle1.10697108
52MP0002080_prenatal_lethality1.04972844
53MP0001661_extended_life_span1.03041919
54MP0008932_abnormal_embryonic_tissue1.01649267
55MP0004270_analgesia1.01540809
56MP0003183_abnormal_peptide_metabolism1.00673513
57MP0000647_abnormal_sebaceous_gland1.00274003
58MP0004019_abnormal_vitamin_homeostasis0.98813939
59MP0005076_abnormal_cell_differentiation0.98465122
60MP0002019_abnormal_tumor_incidence0.97813173
61MP0009672_abnormal_birth_weight0.97179806
62MP0010630_abnormal_cardiac_muscle0.96815260
63MP0004233_abnormal_muscle_weight0.94280382
64MP0000313_abnormal_cell_death0.93627019
65MP0005397_hematopoietic_system_phenotyp0.91390951
66MP0001545_abnormal_hematopoietic_system0.91390951
67MP0001944_abnormal_pancreas_morphology0.90986574
68MP0005085_abnormal_gallbladder_physiolo0.90215044
69MP0005375_adipose_tissue_phenotype0.89950575
70MP0001929_abnormal_gametogenesis0.88223936
71MP0000358_abnormal_cell_content/0.87012525
72MP0002118_abnormal_lipid_homeostasis0.81867866
73MP0000609_abnormal_liver_physiology0.81481026
74MP0002084_abnormal_developmental_patter0.80592400
75MP0000598_abnormal_liver_morphology0.79410387
76MP0003123_paternal_imprinting0.78644500
77MP0002163_abnormal_gland_morphology0.77912259
78MP0002277_abnormal_respiratory_mucosa0.77291583
79MP0002090_abnormal_vision0.77113145
80MP0005646_abnormal_pituitary_gland0.77096694
81MP0003303_peritoneal_inflammation0.74884355
82MP0003698_abnormal_male_reproductive0.74195033
83MP0003786_premature_aging0.73774910
84MP0001666_abnormal_nutrient_absorption0.72487448
85MP0005310_abnormal_salivary_gland0.72042159
86MP0002693_abnormal_pancreas_physiology0.71536206
87MP0002078_abnormal_glucose_homeostasis0.70906900
88MP0001919_abnormal_reproductive_system0.70729667
89MP0002006_tumorigenesis0.70454265
90MP0000689_abnormal_spleen_morphology0.70431593
91MP0005389_reproductive_system_phenotype0.69970643
92MP0001324_abnormal_eye_pigmentation0.69574579
93MP0005334_abnormal_fat_pad0.68036099
94MP0002398_abnormal_bone_marrow0.68023142
95MP0000653_abnormal_sex_gland0.67698528
96MP0005464_abnormal_platelet_physiology0.67285158
97MP0001145_abnormal_male_reproductive0.67184399
98MP0003690_abnormal_glial_cell0.66818945
99MP0004924_abnormal_behavior0.66713147
100MP0005386_behavior/neurological_phenoty0.66713147

Predicted human phenotypes

RankGene SetZ-score
1Acute lymphatic leukemia (HP:0006721)4.36767445
2Prominent metopic ridge (HP:0005487)3.97061501
3Papillary thyroid carcinoma (HP:0002895)3.92555633
4Hyperinsulinemic hypoglycemia (HP:0000825)3.87961554
5Difficulty running (HP:0009046)3.85321905
6Pelvic girdle muscle weakness (HP:0003749)3.83710272
73-Methylglutaconic aciduria (HP:0003535)3.82502459
8Calf muscle hypertrophy (HP:0008981)3.71023577
9Prolonged partial thromboplastin time (HP:0003645)3.65265825
10Shoulder girdle muscle weakness (HP:0003547)3.60317333
11Abnormality of the metopic suture (HP:0005556)3.41524749
12Abnormality of the musculature of the pelvis (HP:0001469)3.38307455
13Abnormality of the hip-girdle musculature (HP:0001445)3.38307455
14Thyroid carcinoma (HP:0002890)3.35791253
15Abnormality of the intrinsic pathway (HP:0010989)3.32833972
16Broad alveolar ridges (HP:0000187)3.30747462
17Hypoglycemic seizures (HP:0002173)3.30517147
18Diastasis recti (HP:0001540)3.25377134
19Central scotoma (HP:0000603)3.17804493
20Abnormality of the pancreatic islet cells (HP:0006476)3.14476738
21Abnormality of endocrine pancreas physiology (HP:0012093)3.14476738
22Vertebral arch anomaly (HP:0008438)3.12765018
23Muscle hypertrophy of the lower extremities (HP:0008968)3.12435035
24Testicular atrophy (HP:0000029)3.12246867
25Proximal amyotrophy (HP:0007126)3.09430558
26Microvesicular hepatic steatosis (HP:0001414)3.08139816
27Overlapping toe (HP:0001845)3.04227483
28Congenital primary aphakia (HP:0007707)2.99163831
29Poikiloderma (HP:0001029)2.97308346
30Abnormality of DNA repair (HP:0003254)2.88134729
31Colon cancer (HP:0003003)2.85352252
32Abnormality of the lumbar spine (HP:0100712)2.84513956
33Asymmetry of the thorax (HP:0001555)2.79717612
34Termporal pattern (HP:0011008)2.75591933
35Insidious onset (HP:0003587)2.75591933
36Reticulocytosis (HP:0001923)2.73501221
37Abnormality of chromosome stability (HP:0003220)2.71672257
38Retinal atrophy (HP:0001105)2.70866690
39Gait imbalance (HP:0002141)2.70738583
40Abnormal gallbladder physiology (HP:0012438)2.65263687
41Cholecystitis (HP:0001082)2.65263687
42Acute myeloid leukemia (HP:0004808)2.65148456
43Entropion (HP:0000621)2.62915853
44Increased density of long bones (HP:0006392)2.59675209
45Anhidrosis (HP:0000970)2.57474732
46Medial flaring of the eyebrow (HP:0010747)2.53738798
47Rhabdomyosarcoma (HP:0002859)2.52929754
48Nephrogenic diabetes insipidus (HP:0009806)2.52167877
49Macroorchidism (HP:0000053)2.40837346
50Ketoacidosis (HP:0001993)2.40781767
51Hyperammonemia (HP:0001987)2.39408519
52Flat acetabular roof (HP:0003180)2.32285975
53Dyschromatopsia (HP:0007641)2.30326525
54Methylmalonic aciduria (HP:0012120)2.26973668
55Poor coordination (HP:0002370)2.26236273
56Thickened calvaria (HP:0002684)2.25738672
57Hyperglycinemia (HP:0002154)2.23719639
58Methylmalonic acidemia (HP:0002912)2.22543676
59Increased circulating renin level (HP:0000848)2.13939790
60Hypoglycemic coma (HP:0001325)2.12345236
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09848019
62Abnormality of homocysteine metabolism (HP:0010919)2.08349659
63Homocystinuria (HP:0002156)2.08349659
64Abnormality of methionine metabolism (HP:0010901)2.08327591
65Menstrual irregularities (HP:0000858)2.07409693
66Abnormality of serum amino acid levels (HP:0003112)2.06439342
67Broad palm (HP:0001169)2.01368119
68Hyperglycemia (HP:0003074)2.01195267
69Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.98560153
70Abnormality of reticulocytes (HP:0004312)1.98516341
71Decreased central vision (HP:0007663)1.97670567
72Abnormality of the periventricular white matter (HP:0002518)1.97529817
73Ketosis (HP:0001946)1.95201241
74Acanthocytosis (HP:0001927)1.90276866
75Abnormality of macular pigmentation (HP:0008002)1.89145340
76Abnormality of glycine metabolism (HP:0010895)1.88836445
77Abnormality of serine family amino acid metabolism (HP:0010894)1.88836445
78Testicular neoplasm (HP:0010788)1.88293674
79Progressive external ophthalmoplegia (HP:0000590)1.88277996
80Broad foot (HP:0001769)1.87853995
81Vaginal atresia (HP:0000148)1.87215572
82Genital tract atresia (HP:0001827)1.86301647
83Cone-rod dystrophy (HP:0000548)1.86293914
84Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85497248
85Chromsome breakage (HP:0040012)1.81864361
86Progressive hearing impairment (HP:0001730)1.81508749
87Symptomatic seizures (HP:0011145)1.80423400
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80116372
89Abnormality of alanine metabolism (HP:0010916)1.80116372
90Hyperalaninemia (HP:0003348)1.80116372
91Freckling (HP:0001480)1.79171802
92Intrahepatic cholestasis (HP:0001406)1.78110183
93Abnormality of sulfur amino acid metabolism (HP:0004339)1.77354566
94Hypercholesterolemia (HP:0003124)1.77293866
95Hematochezia (HP:0002573)1.74079917
96Joint hemorrhage (HP:0005261)1.72122935
97Myelodysplasia (HP:0002863)1.71119490
98Broad ribs (HP:0000885)1.70843075
99Cutaneous melanoma (HP:0012056)1.68857835
100Panhypogammaglobulinemia (HP:0003139)1.68361814

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM285.71548620
2TAOK34.05384217
3FRK3.72356239
4NLK3.14017104
5MAP3K42.72954928
6PASK2.51238896
7FLT32.37619403
8FGFR32.17208311
9MAP3K22.06648188
10PBK2.01033530
11FGFR21.91731472
12TNIK1.84477489
13BCKDK1.80658591
14WEE11.78845399
15BRSK21.65899079
16MAP3K71.55253976
17CAMKK21.51174538
18PKN21.49483822
19MATK1.48294459
20NEK91.47225912
21CDC71.44056673
22TNK21.34104799
23MAP3K61.33869117
24STK381.30637075
25WNK41.30412088
26MKNK11.29889165
27SRPK11.29114727
28LATS11.28895962
29EIF2AK31.22189149
30RPS6KA41.21599722
31BRD41.21452611
32AKT31.17067936
33TTK1.15082422
34RIPK41.09752870
35TSSK61.08975186
36FER1.07250059
37MAP2K31.04495664
38CAMK1D0.99880409
39SIK20.98910604
40PINK10.98030636
41SGK20.97618309
42WNK30.96539173
43MKNK20.94862009
44BMX0.92352986
45STK38L0.92084985
46RET0.90985339
47CDK120.89591458
48RPS6KB20.87678219
49ATR0.86665502
50CDK60.81567036
51EEF2K0.80290655
52TXK0.78958937
53CDK190.77046413
54IRAK10.74170053
55EIF2AK20.74082566
56CSF1R0.71980896
57WNK10.70767600
58ATM0.69383094
59IRAK20.69250416
60KIT0.68782491
61NUAK10.66649529
62PLK30.64360904
63PNCK0.64210700
64CDK30.64018394
65MAP2K60.63030988
66STK110.62766845
67TEC0.61377889
68PLK40.61193753
69DYRK1A0.59745878
70EIF2AK10.58359103
71SCYL20.58192267
72DYRK1B0.55929884
73PRKAA20.55140175
74YES10.55071406
75CHEK10.54802595
76PLK10.54051916
77TRPM70.53937351
78DYRK30.52986415
79SGK2230.51756137
80SGK4940.51756137
81BRSK10.50854649
82NEK10.49449297
83FGFR10.49196832
84PRKAA10.48051121
85NTRK20.46175543
86SYK0.46026427
87HIPK20.45767434
88JAK10.44900957
89CSNK1G10.42170662
90NEK20.41366511
91SGK30.40143495
92CDK20.39392189
93FGFR40.39186283
94CDK40.38103533
95ALK0.37011054
96MAP2K40.36160406
97CAMK1G0.36110774
98RPS6KB10.34174224
99CSNK2A20.33419046
100NTRK30.33176994

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.79787007
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.22585098
3DNA replication_Homo sapiens_hsa030303.86612338
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.68814921
5Mismatch repair_Homo sapiens_hsa034303.43945707
6Base excision repair_Homo sapiens_hsa034102.85937450
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.82695576
8Homologous recombination_Homo sapiens_hsa034402.67194308
9Nucleotide excision repair_Homo sapiens_hsa034202.35527634
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27044231
11Butanoate metabolism_Homo sapiens_hsa006502.22314521
12RNA degradation_Homo sapiens_hsa030182.21729201
13Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.00681967
14Propanoate metabolism_Homo sapiens_hsa006401.98971481
15Fatty acid biosynthesis_Homo sapiens_hsa000611.84490106
16Non-homologous end-joining_Homo sapiens_hsa034501.72070853
17Lysine degradation_Homo sapiens_hsa003101.64084499
18Fanconi anemia pathway_Homo sapiens_hsa034601.60667436
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.56929796
20RNA transport_Homo sapiens_hsa030131.56281064
21Regulation of autophagy_Homo sapiens_hsa041401.50019723
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46684490
23mRNA surveillance pathway_Homo sapiens_hsa030151.40972616
24Spliceosome_Homo sapiens_hsa030401.37881161
25Nitrogen metabolism_Homo sapiens_hsa009101.35566355
26Selenocompound metabolism_Homo sapiens_hsa004501.35080726
27Fatty acid metabolism_Homo sapiens_hsa012121.29660346
28Biosynthesis of amino acids_Homo sapiens_hsa012301.28895069
29Steroid biosynthesis_Homo sapiens_hsa001001.25282550
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.22338226
31mTOR signaling pathway_Homo sapiens_hsa041501.18025259
32Pyruvate metabolism_Homo sapiens_hsa006201.06209133
33Fatty acid elongation_Homo sapiens_hsa000621.06098731
34Glucagon signaling pathway_Homo sapiens_hsa049221.00548446
35Type II diabetes mellitus_Homo sapiens_hsa049301.00417327
36Inositol phosphate metabolism_Homo sapiens_hsa005620.94604195
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91626591
38ABC transporters_Homo sapiens_hsa020100.90794941
39Carbon metabolism_Homo sapiens_hsa012000.89802873
40Fatty acid degradation_Homo sapiens_hsa000710.87617772
41Purine metabolism_Homo sapiens_hsa002300.87554425
42N-Glycan biosynthesis_Homo sapiens_hsa005100.86254393
43Basal transcription factors_Homo sapiens_hsa030220.85485068
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85253107
45One carbon pool by folate_Homo sapiens_hsa006700.83619359
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83406063
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82233089
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82014744
49Cell cycle_Homo sapiens_hsa041100.78761261
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.75544000
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74441105
52* Taste transduction_Homo sapiens_hsa047420.71333201
53Long-term potentiation_Homo sapiens_hsa047200.68722528
54Thyroid cancer_Homo sapiens_hsa052160.66433841
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.66131162
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65864081
57AMPK signaling pathway_Homo sapiens_hsa041520.64118759
58beta-Alanine metabolism_Homo sapiens_hsa004100.63339130
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.63154952
60Peroxisome_Homo sapiens_hsa041460.62956375
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62591843
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60842110
63Complement and coagulation cascades_Homo sapiens_hsa046100.56889902
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56598390
65Oocyte meiosis_Homo sapiens_hsa041140.55505801
66Protein export_Homo sapiens_hsa030600.54822693
67FoxO signaling pathway_Homo sapiens_hsa040680.53951274
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53204645
69Galactose metabolism_Homo sapiens_hsa000520.52627631
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51384938
71Pyrimidine metabolism_Homo sapiens_hsa002400.49642272
72Renin secretion_Homo sapiens_hsa049240.49014974
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47875169
74Insulin secretion_Homo sapiens_hsa049110.45778994
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44834422
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.43706181
77Sulfur metabolism_Homo sapiens_hsa009200.43538147
78Other glycan degradation_Homo sapiens_hsa005110.41545807
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39693707
80Olfactory transduction_Homo sapiens_hsa047400.39240022
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.39031400
82Amphetamine addiction_Homo sapiens_hsa050310.37311234
83Legionellosis_Homo sapiens_hsa051340.36407163
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35980161
85Thyroid hormone synthesis_Homo sapiens_hsa049180.35661604
86Insulin resistance_Homo sapiens_hsa049310.34329513
87Insulin signaling pathway_Homo sapiens_hsa049100.33993804
88p53 signaling pathway_Homo sapiens_hsa041150.30952814
89Fructose and mannose metabolism_Homo sapiens_hsa000510.30588656
90Wnt signaling pathway_Homo sapiens_hsa043100.30206800
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27830200
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26919969
93Ether lipid metabolism_Homo sapiens_hsa005650.25944755
94Arachidonic acid metabolism_Homo sapiens_hsa005900.25233939
95Fat digestion and absorption_Homo sapiens_hsa049750.23982044
96Glutathione metabolism_Homo sapiens_hsa004800.23720011
97Acute myeloid leukemia_Homo sapiens_hsa052210.23125962
98HIF-1 signaling pathway_Homo sapiens_hsa040660.21550352
99Nicotine addiction_Homo sapiens_hsa050330.19750739
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18610738

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