TAS2R50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). See also TAS2R10 (MIM 604791). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular filtration (GO:0003094)9.40472351
2glomerular basement membrane development (GO:0032836)8.91204234
3negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)8.62278546
4renal filtration (GO:0097205)8.35306270
5neuronal stem cell maintenance (GO:0097150)7.39092041
6neuron fate determination (GO:0048664)7.38961614
7chondrocyte development (GO:0002063)6.95561079
8radial glial cell differentiation (GO:0060019)6.88312558
9spermatid nucleus differentiation (GO:0007289)6.57436530
10regulation of cardioblast proliferation (GO:0003264)6.53216069
11regulation of secondary heart field cardioblast proliferation (GO:0003266)6.53216069
12cell morphogenesis involved in neuron differentiation (GO:0048667)6.26536361
13negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)6.05065730
14nephron tubule morphogenesis (GO:0072078)5.89553358
15nephron epithelium morphogenesis (GO:0072088)5.89553358
16innervation (GO:0060384)5.77397072
17negative regulation of glial cell proliferation (GO:0060253)5.71417051
18negative regulation of oligodendrocyte differentiation (GO:0048715)5.58632002
19regulation of organ formation (GO:0003156)5.42819030
20positive regulation of astrocyte differentiation (GO:0048711)5.42635980
21positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.35693662
22regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.35693662
23ventricular septum development (GO:0003281)5.17186291
24centriole replication (GO:0007099)5.00636769
25positive regulation of BMP signaling pathway (GO:0030513)4.59278706
26regulation of timing of cell differentiation (GO:0048505)4.57737962
27serotonin receptor signaling pathway (GO:0007210)4.48145285
28renal tubule morphogenesis (GO:0061333)4.46368527
29regulation of development, heterochronic (GO:0040034)4.32819262
30negative regulation of epidermal cell differentiation (GO:0045605)4.32654297
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.30990402
32ventricular septum morphogenesis (GO:0060412)4.30869087
33negative regulation of smooth muscle cell differentiation (GO:0051151)4.27422426
34negative regulation of axon guidance (GO:1902668)4.22493857
35positive regulation of embryonic development (GO:0040019)4.17309994
36forebrain neuron differentiation (GO:0021879)4.13491285
37cardiac septum development (GO:0003279)4.12087601
38cranial nerve development (GO:0021545)4.09433785
39tongue development (GO:0043586)4.02809640
40negative regulation of glial cell differentiation (GO:0045686)3.99157114
41ovulation from ovarian follicle (GO:0001542)3.98602138
42regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.93308434
43positive regulation of glial cell differentiation (GO:0045687)3.90966880
44regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)3.88330663
45cell-cell signaling involved in cell fate commitment (GO:0045168)3.76910450
46regulation of hexokinase activity (GO:1903299)3.74116477
47regulation of glucokinase activity (GO:0033131)3.74116477
48negative regulation of embryonic development (GO:0045992)3.66302055
49dermatan sulfate biosynthetic process (GO:0030208)3.64649749
50regulation of MHC class I biosynthetic process (GO:0045343)3.55478663
51centrosome duplication (GO:0051298)3.54032075
52translesion synthesis (GO:0019985)3.47278563
53centriole assembly (GO:0098534)3.42208510
54primitive streak formation (GO:0090009)3.39424385
55embryonic skeletal system development (GO:0048706)3.38898027
56positive regulation vascular endothelial growth factor production (GO:0010575)3.38673439
57type B pancreatic cell development (GO:0003323)3.38463888
58protein localization to synapse (GO:0035418)3.38452198
59negative regulation of activin receptor signaling pathway (GO:0032926)3.26763886
60establishment of nucleus localization (GO:0040023)3.26625775
61regulation of glial cell proliferation (GO:0060251)3.25221808
62regulation of oligodendrocyte differentiation (GO:0048713)3.21329701
63epithelial cilium movement (GO:0003351)3.20183873
64retinal ganglion cell axon guidance (GO:0031290)3.15842784
65dermatan sulfate metabolic process (GO:0030205)3.15567507
66regulation of hematopoietic progenitor cell differentiation (GO:1901532)3.14624673
67negative chemotaxis (GO:0050919)3.09838242
68telencephalon development (GO:0021537)3.09643705
69protein polyglutamylation (GO:0018095)3.09337262
70heparan sulfate proteoglycan metabolic process (GO:0030201)3.08105166
71negative regulation of epidermis development (GO:0045683)3.06104597
72endocrine pancreas development (GO:0031018)3.05603382
73cochlea development (GO:0090102)3.04831062
74axon ensheathment in central nervous system (GO:0032291)3.03029814
75central nervous system myelination (GO:0022010)3.03029814
76regulation of astrocyte differentiation (GO:0048710)3.02888147
77negative regulation of axon extension involved in axon guidance (GO:0048843)2.99750723
78nuclear pore organization (GO:0006999)2.98118871
79positive regulation of Notch signaling pathway (GO:0045747)2.97877960
80lateral sprouting from an epithelium (GO:0060601)2.97705181
81midbrain development (GO:0030901)2.97290860
82natural killer cell activation involved in immune response (GO:0002323)2.95460116
83labyrinthine layer blood vessel development (GO:0060716)2.93871916
84cytidine catabolic process (GO:0006216)2.93425665
85cytidine deamination (GO:0009972)2.93425665
86cytidine metabolic process (GO:0046087)2.93425665
87positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.93293480
88smooth muscle contraction (GO:0006939)2.92860594
89bone development (GO:0060348)2.91664333
90axon extension involved in axon guidance (GO:0048846)2.85555521
91neuron projection extension involved in neuron projection guidance (GO:1902284)2.85555521
92negative regulation of mast cell activation (GO:0033004)2.84296634
93regulation of synapse structural plasticity (GO:0051823)2.83261863
94pyrimidine ribonucleoside catabolic process (GO:0046133)2.82805064
95axonal fasciculation (GO:0007413)2.82777978
96neural crest cell development (GO:0014032)2.82424531
97somatic hypermutation of immunoglobulin genes (GO:0016446)2.78809738
98somatic diversification of immune receptors via somatic mutation (GO:0002566)2.78809738
99mitotic cell cycle arrest (GO:0071850)2.78433069
100negative regulation of gliogenesis (GO:0014014)2.78146882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.88339855
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.69546557
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.53164275
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.41231514
5TAF15_26573619_Chip-Seq_HEK293_Human3.14150133
6GBX2_23144817_ChIP-Seq_PC3_Human2.95812701
7* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.86509701
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.80043849
9GATA1_22025678_ChIP-Seq_K562_Human2.77533611
10VDR_22108803_ChIP-Seq_LS180_Human2.52960811
11PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.23673293
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.21901973
13FUS_26573619_Chip-Seq_HEK293_Human2.21403403
14P300_19829295_ChIP-Seq_ESCs_Human2.16394419
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.10089358
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06926746
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.04837535
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97746465
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94758911
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90685713
21E2F7_22180533_ChIP-Seq_HELA_Human1.88523180
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85197276
23EWS_26573619_Chip-Seq_HEK293_Human1.82274701
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.78377909
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75821418
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.73012598
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72536421
28SMAD4_21799915_ChIP-Seq_A2780_Human1.66988194
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.66580220
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66423610
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.66029105
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65678855
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.61091805
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.61091805
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60852071
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58877643
37AR_21572438_ChIP-Seq_LNCaP_Human1.56354156
38BCAT_22108803_ChIP-Seq_LS180_Human1.56247380
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55150785
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.54262146
41ZNF274_21170338_ChIP-Seq_K562_Hela1.51642976
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51392117
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51392117
44RNF2_27304074_Chip-Seq_NSC_Mouse1.51218938
45CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.50910054
46STAT3_23295773_ChIP-Seq_U87_Human1.47519020
47TP53_16413492_ChIP-PET_HCT116_Human1.43275445
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.42284804
49ER_23166858_ChIP-Seq_MCF-7_Human1.42276057
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.41541711
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.39148408
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36599043
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.36365885
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35988763
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34719318
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32681218
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.32662662
58TBX3_20139965_ChIP-Seq_MESCs_Mouse1.32659183
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31623099
60SOX9_26525672_Chip-Seq_HEART_Mouse1.31220021
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30999470
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30820108
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30370438
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30359716
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30076508
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28459152
67KDM2B_26808549_Chip-Seq_REH_Human1.28284855
68TBX3_20139965_ChIP-Seq_ESCs_Mouse1.28277695
69ISL1_27105846_Chip-Seq_CPCs_Mouse1.28094793
70TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.25170920
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24320680
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.22184440
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.18458254
74LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17316402
75FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16945310
76P53_22387025_ChIP-Seq_ESCs_Mouse1.16464958
77IGF1R_20145208_ChIP-Seq_DFB_Human1.15578738
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15514754
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.13635746
80TP53_18474530_ChIP-ChIP_U2OS_Human1.13308716
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.13304379
82AR_25329375_ChIP-Seq_VCAP_Human1.13027335
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12778919
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.11808638
85TCF4_23295773_ChIP-Seq_U87_Human1.11293372
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10819452
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09679116
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09091076
89CBP_20019798_ChIP-Seq_JUKART_Human1.09091076
90JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08011225
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05206245
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04897073
93AHR_22903824_ChIP-Seq_MCF-7_Human1.04767151
94NANOG_19829295_ChIP-Seq_ESCs_Human1.02025338
95SOX2_19829295_ChIP-Seq_ESCs_Human1.02025338
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01828278
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01774783
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.01590743
99E2F4_17652178_ChIP-ChIP_JURKAT_Human1.00445811
100JUN_21703547_ChIP-Seq_K562_Human0.99193869

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.25530099
2MP0000569_abnormal_digit_pigmentation5.34110394
3MP0002653_abnormal_ependyma_morphology4.92253797
4MP0005084_abnormal_gallbladder_morpholo4.07113139
5MP0000383_abnormal_hair_follicle3.80899643
6MP0002822_catalepsy3.31937252
7MP0000467_abnormal_esophagus_morphology2.95134159
8MP0002751_abnormal_autonomic_nervous2.81073088
9MP0002928_abnormal_bile_duct2.76297641
10MP0005499_abnormal_olfactory_system2.48230755
11MP0005394_taste/olfaction_phenotype2.48230755
12MP0008995_early_reproductive_senescence2.46619157
13MP0003950_abnormal_plasma_membrane2.43560267
14MP0010678_abnormal_skin_adnexa2.35946626
15MP0009053_abnormal_anal_canal2.21066677
16MP0005174_abnormal_tail_pigmentation2.13103999
17MP0000427_abnormal_hair_cycle2.11561415
18MP0000534_abnormal_ureter_morphology2.06964454
19MP0008789_abnormal_olfactory_epithelium2.06629175
20MP0003890_abnormal_embryonic-extraembry1.99506833
21MP0005171_absent_coat_pigmentation1.98069839
22MP0010307_abnormal_tumor_latency1.95251344
23MP0002102_abnormal_ear_morphology1.89990431
24MP0000015_abnormal_ear_pigmentation1.87647809
25MP0008057_abnormal_DNA_replication1.82652960
26MP0000371_diluted_coat_color1.81966022
27MP0005075_abnormal_melanosome_morpholog1.79953617
28MP0006072_abnormal_retinal_apoptosis1.78233059
29MP0000631_abnormal_neuroendocrine_gland1.66838050
30MP0001286_abnormal_eye_development1.65947006
31MP0001293_anophthalmia1.60517173
32MP0000778_abnormal_nervous_system1.59459943
33MP0008877_abnormal_DNA_methylation1.50584927
34MP0003329_amyloid_beta_deposits1.48463848
35MP0000647_abnormal_sebaceous_gland1.46341381
36MP0003122_maternal_imprinting1.39695242
37MP0003942_abnormal_urinary_system1.38224572
38MP0002095_abnormal_skin_pigmentation1.33139550
39MP0004133_heterotaxia1.30259916
40MP0005195_abnormal_posterior_eye1.26062767
41MP0004142_abnormal_muscle_tone1.21387376
42MP0002932_abnormal_joint_morphology1.20536105
43MP0003121_genomic_imprinting1.19921872
44MP0002282_abnormal_trachea_morphology1.18715251
45MP0003880_abnormal_central_pattern1.18572399
46MP0000955_abnormal_spinal_cord1.17542072
47MP0002277_abnormal_respiratory_mucosa1.16376041
48MP0002697_abnormal_eye_size1.15718339
49MP0005551_abnormal_eye_electrophysiolog1.15345663
50MP0000604_amyloidosis1.15012710
51MP0001663_abnormal_digestive_system1.12056489
52MP0001984_abnormal_olfaction1.11681143
53MP0005253_abnormal_eye_physiology1.10633386
54MP0008770_decreased_survivor_rate1.07362269
55MP0003632_abnormal_nervous_system0.99887717
56MP0001324_abnormal_eye_pigmentation0.98877486
57MP0000013_abnormal_adipose_tissue0.98387958
58MP0001485_abnormal_pinna_reflex0.98098394
59MP0002075_abnormal_coat/hair_pigmentati0.93545217
60MP0005381_digestive/alimentary_phenotyp0.92203124
61MP0005083_abnormal_biliary_tract0.89051902
62MP0002009_preneoplasia0.88784729
63MP0000432_abnormal_head_morphology0.84545599
64MP0005391_vision/eye_phenotype0.82610040
65MP0003941_abnormal_skin_development0.78099921
66MP0002111_abnormal_tail_morphology0.77917184
67MP0010386_abnormal_urinary_bladder0.77590364
68MP0003011_delayed_dark_adaptation0.76500004
69MP0002233_abnormal_nose_morphology0.74487971
70MP0002752_abnormal_somatic_nervous0.74422051
71MP0005310_abnormal_salivary_gland0.71973904
72MP0002084_abnormal_developmental_patter0.65661049
73MP0002234_abnormal_pharynx_morphology0.65100942
74MP0000026_abnormal_inner_ear0.63890276
75MP0002882_abnormal_neuron_morphology0.63699017
76MP0008875_abnormal_xenobiotic_pharmacok0.63117826
77MP0010094_abnormal_chromosome_stability0.62905703
78MP0004130_abnormal_muscle_cell0.62331209
79MP0002081_perinatal_lethality0.60865467
80MP0003861_abnormal_nervous_system0.59880952
81MP0004381_abnormal_hair_follicle0.58691660
82MP0001186_pigmentation_phenotype0.58218470
83MP0002067_abnormal_sensory_capabilities0.58152527
84MP0002160_abnormal_reproductive_system0.57983375
85MP0002088_abnormal_embryonic_growth/wei0.56235972
86MP0003937_abnormal_limbs/digits/tail_de0.55782757
87MP0006292_abnormal_olfactory_placode0.55673342
88MP0008058_abnormal_DNA_repair0.54667420
89MP0010352_gastrointestinal_tract_polyps0.54093756
90MP0000372_irregular_coat_pigmentation0.53590166
91MP0006276_abnormal_autonomic_nervous0.53405034
92MP0003283_abnormal_digestive_organ0.53154668
93MP0002116_abnormal_craniofacial_bone0.50046729
94MP0002085_abnormal_embryonic_tissue0.49964427
95MP0003984_embryonic_growth_retardation0.49331485
96MP0002837_dystrophic_cardiac_calcinosis0.47605135
97MP0002109_abnormal_limb_morphology0.47458161
98MP0005380_embryogenesis_phenotype0.46660854
99MP0001672_abnormal_embryogenesis/_devel0.46660854
100MP0003943_abnormal_hepatobiliary_system0.45877866

Predicted human phenotypes

RankGene SetZ-score
1Bilateral sensorineural hearing impairment (HP:0008619)5.28498923
2Synostosis involving bones of the lower limbs (HP:0009138)4.68653917
3Synostosis involving bones of the feet (HP:0009140)4.68653917
4Tarsal synostosis (HP:0008368)4.50443401
5Abnormality of incisor morphology (HP:0011063)4.49984140
6Aplasia/Hypoplasia of the uvula (HP:0010293)4.39870990
7Central scotoma (HP:0000603)4.33522783
8Carpal synostosis (HP:0009702)4.01672707
9Septo-optic dysplasia (HP:0100842)3.85715225
10Genetic anticipation (HP:0003743)3.68949796
11Abnormality of the distal phalanx of the thumb (HP:0009617)3.51220997
12Esophageal atresia (HP:0002032)3.46674745
13Scanning speech (HP:0002168)3.45780796
14Absent/shortened dynein arms (HP:0200106)3.43058049
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.43058049
16Deep philtrum (HP:0002002)3.38110250
17Pancreatic cysts (HP:0001737)3.31429799
18Synostosis involving bones of the hand (HP:0004278)3.29826426
19Abnormality of macular pigmentation (HP:0008002)3.29478892
20Synostosis of carpal bones (HP:0005048)3.29254079
21Ulnar deviation of finger (HP:0009465)3.24284089
22Scotoma (HP:0000575)3.21897130
23Gastrointestinal atresia (HP:0002589)3.14143999
24Large earlobe (HP:0009748)3.13101956
25Bifid tongue (HP:0010297)3.10354329
26Intestinal atresia (HP:0011100)3.03589679
27Rib fusion (HP:0000902)2.98931237
28Abnormality of the fovea (HP:0000493)2.96634668
29Chronic hepatic failure (HP:0100626)2.95447611
30Short metatarsal (HP:0010743)2.93132970
31Progressive cerebellar ataxia (HP:0002073)2.83282783
32Abnormality of the incisor (HP:0000676)2.81687643
33Ulnar deviation of the hand or of fingers of the hand (HP:0001193)2.81043399
34Congenital primary aphakia (HP:0007707)2.74540435
35Broad foot (HP:0001769)2.73605599
36Ankle contracture (HP:0006466)2.73098716
37Gait imbalance (HP:0002141)2.71390924
38Sclerocornea (HP:0000647)2.67914731
39Deviation of the thumb (HP:0009603)2.63690623
40Pancreatic fibrosis (HP:0100732)2.58305012
41Thickened calvaria (HP:0002684)2.57427378
42Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.54307168
43Medial flaring of the eyebrow (HP:0010747)2.53344280
44Nephrogenic diabetes insipidus (HP:0009806)2.52967460
45Acanthocytosis (HP:0001927)2.50512544
46Poor coordination (HP:0002370)2.45673904
47Optic nerve hypoplasia (HP:0000609)2.43974449
48True hermaphroditism (HP:0010459)2.43033973
49Dysmetric saccades (HP:0000641)2.42731599
50Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.42667181
51Abnormal ciliary motility (HP:0012262)2.38549672
52Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.36649101
53Vaginal atresia (HP:0000148)2.33685740
54Genital tract atresia (HP:0001827)2.29155011
55Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.25657852
56Submucous cleft hard palate (HP:0000176)2.23033350
57Molar tooth sign on MRI (HP:0002419)2.20148572
58Abnormality of midbrain morphology (HP:0002418)2.20148572
59Anophthalmia (HP:0000528)2.15289292
60Supernumerary spleens (HP:0009799)2.13485707
61Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.10618329
62Increased number of teeth (HP:0011069)2.10343607
63Spastic diplegia (HP:0001264)2.08638018
64Gaze-evoked nystagmus (HP:0000640)2.08282763
65Anal stenosis (HP:0002025)2.07692482
66Abnormality of the upper arm (HP:0001454)2.07616080
67Short middle phalanx of the 5th finger (HP:0004220)2.04462309
68Abnormality of the humerus (HP:0003063)2.03346721
69Abnormality of the phalanges of the 5th finger (HP:0004213)1.98328107
70Hypoplastic labia majora (HP:0000059)1.97832625
71Impulsivity (HP:0100710)1.97384757
72Albinism (HP:0001022)1.95601872
73Abnormality of the lower motor neuron (HP:0002366)1.95580765
74Short middle phalanx of finger (HP:0005819)1.95243609
75Spontaneous abortion (HP:0005268)1.95050806
76Abnormality of the renal cortex (HP:0011035)1.94706689
77Maternal diabetes (HP:0009800)1.93767386
78Abnormality of the labia majora (HP:0012881)1.93170627
79Partial agenesis of the corpus callosum (HP:0001338)1.92232975
80Abnormal respiratory motile cilium physiology (HP:0012261)1.91374984
81Increased corneal curvature (HP:0100692)1.91309320
82Keratoconus (HP:0000563)1.91309320
83Specific learning disability (HP:0001328)1.91260721
84Cystic liver disease (HP:0006706)1.89367683
85Urinary bladder sphincter dysfunction (HP:0002839)1.85665067
86Mesomelia (HP:0003027)1.85555693
87Vertebral clefting (HP:0008428)1.83192905
88Abnormality of the phalanges of the 2nd finger (HP:0009541)1.83158880
89Bony spicule pigmentary retinopathy (HP:0007737)1.81662086
90Supernumerary ribs (HP:0005815)1.78844027
91Renal cortical cysts (HP:0000803)1.78286559
92Severe Myopia (HP:0011003)1.77540590
93Aplasia/Hypoplasia of the tongue (HP:0010295)1.76344380
94Abnormality of the epiphyses of the hand (HP:0005924)1.75958189
95Renal dysplasia (HP:0000110)1.75866227
96Depressed nasal tip (HP:0000437)1.72562240
97Distal arthrogryposis (HP:0005684)1.71429425
982-3 toe syndactyly (HP:0004691)1.71188080
99Abnormality of the nasal septum (HP:0000419)1.70785020
100Abnormal respiratory epithelium morphology (HP:0012253)1.69964904

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME16.83241835
2TNIK3.37548899
3SGK23.33434649
4IKBKE2.91111181
5ACVR1B2.67431033
6SGK4942.58053354
7SGK2232.58053354
8CASK2.43566301
9STK42.29327374
10FRK2.25130146
11ZAK2.19124081
12TEC2.17980660
13SGK32.16532660
14BMPR1B2.06823506
15NTRK31.90104317
16EPHA31.67955875
17AKT31.65751684
18PIM11.56948695
19WNK11.45412966
20MAP3K41.36119174
21CHUK1.35370066
22PINK11.34280377
23OXSR11.31525411
24NTRK21.27522125
25BCKDK1.23480532
26OBSCN1.17949042
27WNK31.13144166
28CAMK1G1.12144115
29MAP4K21.10099687
30MAP2K21.09642837
31EPHA41.03094790
32ADRBK21.02102790
33CAMK1D1.01805988
34PRKAA20.96349393
35TLK10.95760206
36KSR10.90911228
37MAP2K10.90432410
38MKNK20.90034171
39MAP3K20.87674689
40IKBKB0.85812981
41EIF2AK20.85362745
42WNK40.82863620
43PLK40.81609085
44CDC70.80485174
45IRAK20.78728096
46RPS6KA40.78413436
47CHEK20.75754450
48BCR0.75522192
49NLK0.74202113
50SGK10.68914130
51MELK0.67695461
52PLK10.67273558
53EIF2AK30.63037815
54PLK20.60737684
55BLK0.60516468
56MAPK150.60307211
57TGFBR10.59785036
58IRAK10.59378962
59ERBB30.59122492
60TTK0.59042716
61MAP2K70.57684803
62AURKB0.56709315
63PIK3CG0.54612206
64TIE10.53500166
65GRK10.52184017
66JAK10.50745294
67PRKCE0.50243455
68TRIM280.47408308
69MAP2K40.46751445
70MAPK130.44499658
71RPS6KA30.43719589
72ATR0.43373382
73ERBB20.40526350
74MAP3K60.40487227
75SYK0.39673768
76ADRBK10.39290902
77RPS6KA50.38937904
78AKT10.38698286
79MAP3K30.38372088
80CSNK1D0.37760253
81ATM0.36080683
82CAMK10.35420058
83STK38L0.35248537
84BRSK20.35168154
85STK30.35074337
86IRAK40.32790883
87PKN10.32525663
88DYRK1A0.32335406
89RPS6KB10.32219949
90MKNK10.32021080
91PTK60.31909715
92STK110.31005891
93TRPM70.30313505
94PRKACA0.29681814
95CDK190.29336551
96PAK60.29249889
97PBK0.29038663
98DAPK20.28822513
99EGFR0.28275119
100STK390.27659742

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.31959171
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.91083576
3* Taste transduction_Homo sapiens_hsa047423.34605458
4Propanoate metabolism_Homo sapiens_hsa006403.19338600
5Fanconi anemia pathway_Homo sapiens_hsa034602.79288396
6Selenocompound metabolism_Homo sapiens_hsa004502.67894449
7Nicotine addiction_Homo sapiens_hsa050332.34592244
8Systemic lupus erythematosus_Homo sapiens_hsa053222.24680165
9Homologous recombination_Homo sapiens_hsa034402.23289850
10Vitamin digestion and absorption_Homo sapiens_hsa049772.16632227
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69879488
12Alcoholism_Homo sapiens_hsa050341.60267990
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58951096
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49925774
15Regulation of autophagy_Homo sapiens_hsa041401.49408420
16Basal cell carcinoma_Homo sapiens_hsa052171.48301378
17p53 signaling pathway_Homo sapiens_hsa041151.48191658
18One carbon pool by folate_Homo sapiens_hsa006701.48023529
19TGF-beta signaling pathway_Homo sapiens_hsa043501.41427291
20Non-homologous end-joining_Homo sapiens_hsa034501.40358582
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29872063
22Non-small cell lung cancer_Homo sapiens_hsa052231.21028532
23Serotonergic synapse_Homo sapiens_hsa047261.20477554
24RNA polymerase_Homo sapiens_hsa030201.19465230
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19293564
26GABAergic synapse_Homo sapiens_hsa047271.04981227
27cAMP signaling pathway_Homo sapiens_hsa040241.04078497
28RNA degradation_Homo sapiens_hsa030181.01132961
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00099910
30Colorectal cancer_Homo sapiens_hsa052100.97541138
31Hedgehog signaling pathway_Homo sapiens_hsa043400.97266721
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93498025
33Axon guidance_Homo sapiens_hsa043600.92307048
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91289516
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90015160
36Oocyte meiosis_Homo sapiens_hsa041140.89598717
37Dorso-ventral axis formation_Homo sapiens_hsa043200.87173280
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85241328
39Endometrial cancer_Homo sapiens_hsa052130.85029463
40Pyruvate metabolism_Homo sapiens_hsa006200.84640157
41Hippo signaling pathway_Homo sapiens_hsa043900.83505523
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81485622
43Phototransduction_Homo sapiens_hsa047440.78051780
44Morphine addiction_Homo sapiens_hsa050320.76901005
45Prolactin signaling pathway_Homo sapiens_hsa049170.75891141
46DNA replication_Homo sapiens_hsa030300.75817087
47Ether lipid metabolism_Homo sapiens_hsa005650.73976104
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73908554
49Butanoate metabolism_Homo sapiens_hsa006500.70185718
50Caffeine metabolism_Homo sapiens_hsa002320.69633827
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68970251
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67894233
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65695582
54Calcium signaling pathway_Homo sapiens_hsa040200.65658653
55Mismatch repair_Homo sapiens_hsa034300.64853786
56ABC transporters_Homo sapiens_hsa020100.63975297
57Dopaminergic synapse_Homo sapiens_hsa047280.58327163
58RNA transport_Homo sapiens_hsa030130.57850846
59Cocaine addiction_Homo sapiens_hsa050300.57497127
60mTOR signaling pathway_Homo sapiens_hsa041500.55253949
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55160848
62Notch signaling pathway_Homo sapiens_hsa043300.54117738
63Fat digestion and absorption_Homo sapiens_hsa049750.53777397
64Long-term depression_Homo sapiens_hsa047300.52279109
65FoxO signaling pathway_Homo sapiens_hsa040680.51421182
66Salivary secretion_Homo sapiens_hsa049700.50499254
67Fatty acid biosynthesis_Homo sapiens_hsa000610.50009015
68Glutamatergic synapse_Homo sapiens_hsa047240.48778242
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.47716021
70TNF signaling pathway_Homo sapiens_hsa046680.47239714
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46920602
72Viral carcinogenesis_Homo sapiens_hsa052030.46317348
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46256464
74Legionellosis_Homo sapiens_hsa051340.44664668
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.42897004
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42248162
77Small cell lung cancer_Homo sapiens_hsa052220.42178033
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.42024232
79Tight junction_Homo sapiens_hsa045300.41911932
80Cholinergic synapse_Homo sapiens_hsa047250.41866565
81Cell cycle_Homo sapiens_hsa041100.41628999
82Lysine degradation_Homo sapiens_hsa003100.41079188
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40819590
84Purine metabolism_Homo sapiens_hsa002300.39313739
85Nucleotide excision repair_Homo sapiens_hsa034200.39267379
86Pathways in cancer_Homo sapiens_hsa052000.38449113
87Olfactory transduction_Homo sapiens_hsa047400.37117152
88Steroid biosynthesis_Homo sapiens_hsa001000.35806270
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35567876
90AMPK signaling pathway_Homo sapiens_hsa041520.35523703
91Adherens junction_Homo sapiens_hsa045200.33654005
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32152702
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31925181
94Melanogenesis_Homo sapiens_hsa049160.31610019
95Retinol metabolism_Homo sapiens_hsa008300.30825890
96mRNA surveillance pathway_Homo sapiens_hsa030150.30522874
97Wnt signaling pathway_Homo sapiens_hsa043100.30383997
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29571012
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28915895
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28846929

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