ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of sister chromatid cohesion (GO:0007063)	9.93229536
2	eosinophil migration (GO:0072677)	9.56567389
3	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	9.39761165
4	regulation of mononuclear cell migration (GO:0071675)	9.33790864
5	branch elongation of an epithelium (GO:0060602)	8.32661005
6	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	7.99827584
7	positive regulation of chromosome segregation (GO:0051984)	7.94052439
8	L-fucose catabolic process (GO:0042355)	7.88068399
9	fucose catabolic process (GO:0019317)	7.88068399
10	L-fucose metabolic process (GO:0042354)	7.88068399
11	vesicle fusion (GO:0006906)	7.66577564
12	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	7.59169708
13	peptidyl-lysine dimethylation (GO:0018027)	7.45756741
14	ribosomal small subunit assembly (GO:0000028)	7.15479206
15	coenzyme A biosynthetic process (GO:0015937)	7.10379469
16	autophagic vacuole fusion (GO:0000046)	6.94136812
17	macrophage chemotaxis (GO:0048246)	6.71994089
18	organ growth (GO:0035265)	6.61348788
19	localization within membrane (GO:0051668)	6.47647097
20	axis elongation (GO:0003401)	6.25611320
21	regulation of beta-amyloid formation (GO:1902003)	6.00719458
22	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	5.86044901
23	positive regulation of calcium ion import (GO:0090280)	5.81591204
24	negative regulation of GTPase activity (GO:0034260)	5.79754936
25	negative regulation of GTP catabolic process (GO:0033125)	5.79754936
26	establishment of mitotic spindle orientation (GO:0000132)	5.79447925
27	regulation of T cell receptor signaling pathway (GO:0050856)	5.63926242
28	organelle membrane fusion (GO:0090174)	5.52319431
29	monocyte chemotaxis (GO:0002548)	5.44515046
30	non-recombinational repair (GO:0000726)	5.42865828
31	double-strand break repair via nonhomologous end joining (GO:0006303)	5.42865828
32	protein import into peroxisome matrix (GO:0016558)	5.39031133
33	establishment of mitotic spindle localization (GO:0040001)	5.14501363
34	seminiferous tubule development (GO:0072520)	5.04209871
35	establishment of spindle orientation (GO:0051294)	5.03179849
36	3-UTR-mediated mRNA stabilization (GO:0070935)	4.98167126
37	histone H3-K9 methylation (GO:0051567)	4.95853772
38	oxidative demethylation (GO:0070989)	4.93140280
39	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.85486099
40	positive chemotaxis (GO:0050918)	4.79632511
41	negative regulation of circadian rhythm (GO:0042754)	4.76888911
42	regulation of amyloid precursor protein catabolic process (GO:1902991)	4.75809654
43	organelle fusion (GO:0048284)	4.74413452
44	acrosome assembly (GO:0001675)	4.73537146
45	pantothenate metabolic process (GO:0015939)	4.60706082
46	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	4.54783113
47	protein targeting to lysosome (GO:0006622)	4.53478810
48	establishment of protein localization to vacuole (GO:0072666)	4.53478810
49	protein targeting to vacuole (GO:0006623)	4.53478810
50	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	4.48436289
51	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	4.48436289
52	nucleoside bisphosphate biosynthetic process (GO:0033866)	4.48436289
53	fucose metabolic process (GO:0006004)	4.39761124
54	regulation of stem cell maintenance (GO:2000036)	4.34175661
55	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.31365428
56	regulation of autophagic vacuole assembly (GO:2000785)	4.29129384
57	coenzyme A metabolic process (GO:0015936)	4.19458898
58	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	4.13700840
59	histone H3-K9 modification (GO:0061647)	4.08643645
60	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	4.06468347
61	fucosylation (GO:0036065)	4.06107540
62	negative regulation of purine nucleotide catabolic process (GO:0033122)	3.97288966
63	single-organism membrane fusion (GO:0044801)	3.92673634
64	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	3.89542423
65	membrane budding (GO:0006900)	3.87051278
66	regulation of cellular amide metabolic process (GO:0034248)	3.85404090
67	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.83305818
68	negative regulation of nucleotide catabolic process (GO:0030812)	3.78801452
69	establishment of spindle localization (GO:0051293)	3.72797660
70	negative regulation of nucleoside metabolic process (GO:0045978)	3.62877468
71	regulation of vacuole organization (GO:0044088)	3.58752621
72	DNA integration (GO:0015074)	3.58641670
73	vesicle targeting (GO:0006903)	3.53675618
74	negative regulation of macroautophagy (GO:0016242)	3.52768960
75	DNA demethylation (GO:0080111)	3.52732779
76	sodium-independent organic anion transport (GO:0043252)	3.52415507
77	regulation of calcium ion import (GO:0090279)	3.48809854
78	telomere maintenance via recombination (GO:0000722)	3.47611369
79	regulation of peptidyl-threonine phosphorylation (GO:0010799)	3.47536904
80	protein localization to peroxisome (GO:0072662)	3.44579661
81	protein targeting to peroxisome (GO:0006625)	3.44579661
82	establishment of protein localization to peroxisome (GO:0072663)	3.44579661
83	peptidyl-lysine trimethylation (GO:0018023)	3.42914516
84	imidazole-containing compound metabolic process (GO:0052803)	3.38871636
85	negative regulation of dendrite morphogenesis (GO:0050774)	3.38073092
86	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	3.37335631
87	labyrinthine layer development (GO:0060711)	3.35499447
88	ER to Golgi vesicle-mediated transport (GO:0006888)	3.35128164
89	protein localization to vacuole (GO:0072665)	3.32525267
90	protein localization to lysosome (GO:0061462)	3.32525267
91	protein sumoylation (GO:0016925)	3.29452469
92	preassembly of GPI anchor in ER membrane (GO:0016254)	3.25053362
93	protein prenylation (GO:0018342)	13.0731547
94	prenylation (GO:0097354)	13.0731547
95	positive regulation of mitotic sister chromatid separation (GO:1901970)	12.3708061
96	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	12.3708061
97	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	12.3708061
98	negative regulation of Ras GTPase activity (GO:0034261)	12.0680970
99	eosinophil chemotaxis (GO:0048245)	10.5726797
100	negative regulation of T cell receptor signaling pathway (GO:0050860)	10.1728081

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	8.31176834
2	VDR_22108803_ChIP-Seq_LS180_Human	6.26746967
3	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.69828426
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.30613043
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.73940707
6	AR_21572438_ChIP-Seq_LNCaP_Human	3.56298093
7	ZNF263_19887448_ChIP-Seq_K562_Human	2.87507308
8	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	2.58854347
9	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.52287461
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.44478272
11	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.31682084
12	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.21854056
13	RXR_22108803_ChIP-Seq_LS180_Human	2.02652053
14	GATA1_22025678_ChIP-Seq_K562_Human	11.7672470
15	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.96643879
16	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.96261738
17	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.96261738
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.88944780
19	BCAT_22108803_ChIP-Seq_LS180_Human	1.75072745
20	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.69807205
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.66362947
22	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.56078703
23	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.55022801
24	TP53_16413492_ChIP-PET_HCT116_Human	1.52451625
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.50909276
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.49670881
27	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.39429557
28	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.39429557
29	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.39429557
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.36796215
31	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.36383135
32	GATA3_26560356_Chip-Seq_TH1_Human	1.34451778
33	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27537134
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19397897
35	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.13746260
36	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13618525
37	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.13454860
38	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.08888829
39	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08174610
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.05114505
41	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.03771939
42	RUNX_20019798_ChIP-Seq_JUKART_Human	1.02107625
43	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.00563460
44	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.00496530
45	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.00011823
46	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.98291194
47	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97450937
48	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.96541383
49	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.96324801
50	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.94574902
51	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.92767058
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.92648035
53	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.90411535
54	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.86187745
55	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.85220154
56	FUS_26573619_Chip-Seq_HEK293_Human	0.84760224
57	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.84679460
58	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.81810251
59	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.81582669
60	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.81100261
61	CTCF_21964334_Chip-Seq_Bcells_Human	0.80900498
62	P300_19829295_ChIP-Seq_ESCs_Human	0.78416232
63	ZNF274_21170338_ChIP-Seq_K562_Hela	0.77108066
64	EZH2_22144423_ChIP-Seq_EOC_Human	0.76287203
65	GATA1_19941826_ChIP-Seq_K562_Human	0.71091793
66	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.69836707
67	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.68830846
68	TP53_22573176_ChIP-Seq_HFKS_Human	0.67501676
69	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.67185366
70	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.66615658
71	HTT_18923047_ChIP-ChIP_STHdh_Human	0.66500564
72	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.66375210
73	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.66331720
74	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.65749377
75	TCF4_22108803_ChIP-Seq_LS180_Human	0.65361677
76	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.65338520
77	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.65163934
78	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.64126722
79	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.63805637
80	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.63591669
81	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.61493439
82	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.59461858
83	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.58538775
84	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.57246289
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.57164963
86	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.56202653
87	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.55910053
88	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.55555493
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.55382140
90	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.54792540
91	CBP_20019798_ChIP-Seq_JUKART_Human	0.54792540
92	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.54506862
93	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.54435727
94	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.54349935
95	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.53839761
96	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.53504628
97	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.52190010
98	STAT1_20625510_ChIP-Seq_HELA_Human	0.51351446
99	PU1_27457419_Chip-Seq_LIVER_Mouse	0.51055332
100	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.51018212

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	9.87662076
2	MP0006082_CNS_inflammation	5.41866562
3	MP0000467_abnormal_esophagus_morphology	3.24275309
4	MP0001664_abnormal_digestion	3.22480342
5	MP0001663_abnormal_digestive_system	3.09965188
6	MP0002751_abnormal_autonomic_nervous	2.72669164
7	MP0001919_abnormal_reproductive_system	2.68504770
8	MP0000383_abnormal_hair_follicle	2.66807710
9	MP0003115_abnormal_respiratory_system	2.59704486
10	MP0005381_digestive/alimentary_phenotyp	2.35101408
11	MP0000566_synostosis	12.9216879
12	MP0005076_abnormal_cell_differentiation	1.91969511
13	MP0001915_intracranial_hemorrhage	1.84398537
14	MP0010678_abnormal_skin_adnexa	1.82986388
15	MP0000534_abnormal_ureter_morphology	1.79835419
16	MP0002876_abnormal_thyroid_physiology	1.77208083
17	MP0005166_decreased_susceptibility_to	1.65845199
18	MP0003937_abnormal_limbs/digits/tail_de	1.61696079
19	MP0005389_reproductive_system_phenotype	1.57164287
20	MP0003453_abnormal_keratinocyte_physiol	1.53014702
21	MP0000428_abnormal_craniofacial_morphol	1.47005280
22	MP0001545_abnormal_hematopoietic_system	1.34262521
23	MP0005397_hematopoietic_system_phenotyp	1.34262521
24	MP0002837_dystrophic_cardiac_calcinosis	1.25185909
25	MP0001286_abnormal_eye_development	1.21928536
26	MP0000490_abnormal_crypts_of	1.16336871
27	MP0003763_abnormal_thymus_physiology	1.12013810
28	MP0001293_anophthalmia	1.11897858
29	MP0005501_abnormal_skin_physiology	1.06978335
30	MP0000858_altered_metastatic_potential	1.05737521
31	MP0003942_abnormal_urinary_system	1.05587549
32	MP0002019_abnormal_tumor_incidence	0.97013941
33	MP0002109_abnormal_limb_morphology	0.92521887
34	MP0001764_abnormal_homeostasis	0.91070307
35	MP0001963_abnormal_hearing_physiology	0.87386220
36	MP0002115_abnormal_skeleton_extremities	0.80980667
37	MP0005197_abnormal_uvea_morphology	0.79818995
38	MP0000470_abnormal_stomach_morphology	0.78318470
39	MP0000026_abnormal_inner_ear	0.76488533
40	MP0000358_abnormal_cell_content/	0.72167365
41	MP0000432_abnormal_head_morphology	0.69471014
42	MP0010155_abnormal_intestine_physiology	0.69453269
43	MP0003329_amyloid_beta_deposits	0.69211492
44	MP0000477_abnormal_intestine_morphology	0.65724109
45	MP0009763_increased_sensitivity_to	0.65673533
46	MP0000569_abnormal_digit_pigmentation	0.61953436
47	MP0005023_abnormal_wound_healing	0.60355645
48	MP0001175_abnormal_lung_morphology	0.60215186
49	MP0009672_abnormal_birth_weight	0.58590984
50	MP0003448_altered_tumor_morphology	0.57999188
51	MP0002168_other_aberrant_phenotype	0.57410699
52	MP0005508_abnormal_skeleton_morphology	0.57032737
53	MP0003935_abnormal_craniofacial_develop	0.56803303
54	MP0002405_respiratory_system_inflammati	0.55300888
55	MP0002184_abnormal_innervation	0.54283363
56	MP0005253_abnormal_eye_physiology	0.53925561
57	MP0002210_abnormal_sex_determination	0.52009433
58	MP0002113_abnormal_skeleton_development	0.43985917
59	MP0000604_amyloidosis	0.43217004
60	MP0000377_abnormal_hair_follicle	0.43202129
61	MP0008058_abnormal_DNA_repair	0.42871768
62	MP0000681_abnormal_thyroid_gland	0.42826725
63	MP0000627_abnormal_mammary_gland	0.42709144
64	MP0005391_vision/eye_phenotype	0.41740955
65	MP0002697_abnormal_eye_size	0.39902836
66	MP0000049_abnormal_middle_ear	0.39659931
67	MP0003936_abnormal_reproductive_system	0.38845935
68	MP0002822_catalepsy	0.38378897
69	MP0002735_abnormal_chemical_nociception	0.36893177
70	MP0003638_abnormal_response/metabolism_	0.36769376
71	MP0000372_irregular_coat_pigmentation	0.32901861
72	MP0000350_abnormal_cell_proliferation	0.32671189
73	MP0000163_abnormal_cartilage_morphology	0.32108404
74	MP0005025_abnormal_response_to	0.32027580
75	MP0002752_abnormal_somatic_nervous	0.31883106
76	MP0004885_abnormal_endolymph	0.31067600
77	MP0004084_abnormal_cardiac_muscle	0.30317650
78	MP0003195_calcinosis	0.29533506
79	MP0005423_abnormal_somatic_nervous	0.29197513
80	MP0004197_abnormal_fetal_growth/weight/	0.29141352
81	MP0001485_abnormal_pinna_reflex	0.26441842
82	MP0005395_other_phenotype	0.24882130
83	MP0003315_abnormal_perineum_morphology	0.23624495
84	MP0002092_abnormal_eye_morphology	0.22683566
85	MP0002136_abnormal_kidney_physiology	0.22665742
86	MP0002116_abnormal_craniofacial_bone	0.21827356
87	MP0005195_abnormal_posterior_eye	0.21356344
88	MP0002081_perinatal_lethality	0.19478945
89	MP0010771_integument_phenotype	0.19410291
90	MP0001986_abnormal_taste_sensitivity	0.19385555
91	MP0009931_abnormal_skin_appearance	0.18468589
92	MP0001346_abnormal_lacrimal_gland	0.18111747
93	MP0001119_abnormal_female_reproductive	0.16347475
94	MP0002452_abnormal_antigen_presenting	0.15727451
95	MP0005390_skeleton_phenotype	0.15454912
96	MP0000955_abnormal_spinal_cord	0.15404107
97	MP0003077_abnormal_cell_cycle	0.15061464
98	MP0008004_abnormal_stomach_pH	0.13764287
99	MP0002277_abnormal_respiratory_mucosa	0.13046072
100	MP0008770_decreased_survivor_rate	0.12015610

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	9.00005627
2	Long foot (HP:0001833)	8.74915096
3	Abnormality of the renal collecting system (HP:0004742)	8.06712308
4	Acute lymphatic leukemia (HP:0006721)	7.79260387
5	Adactyly (HP:0009776)	7.34639308
6	Large for gestational age (HP:0001520)	6.75835881
7	Progressive muscle weakness (HP:0003323)	6.59242820
8	Hypoplastic pelvis (HP:0008839)	6.31132137
9	Abnormality of fatty-acid metabolism (HP:0004359)	5.93974059
10	Dry hair (HP:0011359)	5.81413504
11	Autoamputation (HP:0001218)	5.61962995
12	Hypoplastic nipples (HP:0002557)	5.48516779
13	Ureteral stenosis (HP:0000071)	5.48023222
14	Pulmonary artery stenosis (HP:0004415)	5.45347943
15	Ureteral obstruction (HP:0006000)	5.09066276
16	Menstrual irregularities (HP:0000858)	5.01793426
17	Steatorrhea (HP:0002570)	4.94659679
18	Ureteral duplication (HP:0000073)	4.79028729
19	Brushfield spots (HP:0001088)	4.76205717
20	Abnormal auditory evoked potentials (HP:0006958)	4.45255959
21	Reduced subcutaneous adipose tissue (HP:0003758)	4.43020184
22	Sudden death (HP:0001699)	4.15516020
23	Decreased lacrimation (HP:0000633)	4.02693485
24	Increased number of teeth (HP:0011069)	3.99634200
25	Transposition of the great arteries (HP:0001669)	3.93318404
26	Abnormal connection of the cardiac segments (HP:0011545)	3.93318404
27	Abnormal ventriculo-arterial connection (HP:0011563)	3.93318404
28	Severe muscular hypotonia (HP:0006829)	3.86738109
29	Fat malabsorption (HP:0002630)	3.80031357
30	Anhidrosis (HP:0000970)	3.79904927
31	Broad nasal tip (HP:0000455)	3.62145382
32	Broad-based gait (HP:0002136)	3.59762020
33	Palmoplantar hyperkeratosis (HP:0000972)	3.53008663
34	Wide intermamillary distance (HP:0006610)	3.47138112
35	Palmar hyperkeratosis (HP:0010765)	3.36820693
36	Abnormality of vision evoked potentials (HP:0000649)	3.27875629
37	Polyneuropathy (HP:0001271)	3.25094981
38	Decreased muscle mass (HP:0003199)	3.18798257
39	Large hands (HP:0001176)	3.05319265
40	Generalized amyotrophy (HP:0003700)	3.04932203
41	Polymicrogyria (HP:0002126)	2.96012733
42	Myoglobinuria (HP:0002913)	2.88988507
43	Plantar hyperkeratosis (HP:0007556)	2.82557619
44	Widely spaced teeth (HP:0000687)	2.74565232
45	Rhabdomyolysis (HP:0003201)	2.72684390
46	Chorioretinal coloboma (HP:0000567)	2.67505084
47	Flat face (HP:0012368)	2.65375997
48	Clubbing of toes (HP:0100760)	2.63333180
49	Overfolded helix (HP:0000396)	2.61446567
50	Thickened calvaria (HP:0002684)	2.59046795
51	Absent toe (HP:0010760)	2.53585295
52	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.53527401
53	Hypoplastic iliac wings (HP:0002866)	2.42117449
54	Purpura (HP:0000979)	2.36592361
55	Steppage gait (HP:0003376)	2.35639353
56	Abnormally folded helix (HP:0008544)	2.33847630
57	Epiphyseal stippling (HP:0010655)	2.31171759
58	Basal ganglia calcification (HP:0002135)	2.29935664
59	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	2.12681920
60	Female pseudohermaphroditism (HP:0010458)	2.11056241
61	Posterior embryotoxon (HP:0000627)	2.07472312
62	Abnormality of the epiphyses of the hand (HP:0005924)	2.06511971
63	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	11.5316051
64	Abnormality of the line of Schwalbe (HP:0008048)	1.99365441
65	Anxiety (HP:0000739)	1.96464750
66	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.91288290
67	Prenatal maternal abnormality (HP:0002686)	1.90341430
68	External ear malformation (HP:0008572)	1.88584395
69	Foot dorsiflexor weakness (HP:0009027)	1.88084085
70	Stereotypic behavior (HP:0000733)	1.86413159
71	Thickened nuchal skin fold (HP:0000474)	1.79636845
72	Hammertoe (HP:0001765)	1.79358669
73	Short philtrum (HP:0000322)	1.79135812
74	Rectovaginal fistula (HP:0000143)	1.78029367
75	Rectal fistula (HP:0100590)	1.78029367
76	Arthrogryposis multiplex congenita (HP:0002804)	1.73120090
77	Gangrene (HP:0100758)	1.72555205
78	Spastic tetraplegia (HP:0002510)	1.71500000
79	Abnormality of the foot musculature (HP:0001436)	1.69110768
80	Depressed nasal ridge (HP:0000457)	1.67429931
81	Generalized muscle weakness (HP:0003324)	1.65476783
82	Congenital onset (HP:0003577)	1.65211744
83	Abnormality of primary teeth (HP:0006481)	1.64986632
84	Abnormal epiphyseal ossification (HP:0010656)	1.63732276
85	Scrotal hypoplasia (HP:0000046)	1.60758484
86	Primary adrenal insufficiency (HP:0008207)	1.59685410
87	Intestinal fistula (HP:0100819)	1.57447938
88	Hypoproteinemia (HP:0003075)	1.55264481
89	Arterial thrombosis (HP:0004420)	1.54649844
90	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.54564502
91	Decreased motor nerve conduction velocity (HP:0003431)	1.51689116
92	Brachycephaly (HP:0000248)	1.51212965
93	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.46508752
94	Lactic acidosis (HP:0003128)	1.45410575
95	Vaginal fistula (HP:0004320)	1.44578299
96	Hypoplastic ilia (HP:0000946)	1.42771812
97	Postnatal growth retardation (HP:0008897)	1.41870916
98	Underdeveloped supraorbital ridges (HP:0009891)	1.41345238
99	Hypochromic microcytic anemia (HP:0004840)	1.41322970
100	Nail dystrophy (HP:0008404)	1.37995505

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.82080126
2	TAOK1	5.53658733
3	TAOK2	5.51197664
4	MAP3K3	4.08644795
5	MAP3K11	3.98173108
6	MAP2K3	3.93527264
7	PRKCA	3.16317043
8	JAK3	2.42342953
9	MKNK2	11.5368057
10	ABL2	1.88163164
11	DYRK1A	1.73597503
12	MAP3K5	1.40362653
13	MAP3K1	1.14292932
14	SRPK1	1.05531776
15	CHEK2	0.83517848
16	MAP3K8	0.66496097
17	PRKCQ	0.47221705
18	TXK	0.24818400
19	PKN1	0.22480060
20	EPHA3	0.19790703
21	CSNK1A1	0.19292177
22	KDR	0.19040095
23	ABL1	0.18760051
24	TLK1	0.17683921
25	IGF1R	0.16261314
26	FRK	0.15913629
27	MAP4K2	0.14804833
28	ZAK	0.14790660
29	PIK3CA	0.14227217
30	OBSCN	0.13967872
31	INSRR	0.11531519
32	MAPK13	0.10664665
33	GRK1	0.09418315
34	PRKCD	0.08125391
35	WNK3	0.07803133
36	MUSK	0.07493655
37	GRK7	0.05756809
38	CSNK2A2	0.03540172
39	OXSR1	0.03104429
40	PLK4	0.02359176
41	TEC	0.02187061
42	CSNK2A1	0.02075301
43	VRK1	0.01545701
44	ADRBK2	0.01396155
45	CSNK1E	0.01032619
46	PRKCG	-0.1067535
47	MAP2K6	-0.1052441
48	CAMK2B	-0.1033390
49	CAMK2G	-0.1025065
50	WNK4	-0.1009517
51	CDC7	-0.0999195
52	MAP3K2	-0.0989349
53	CDK1	-0.0985988
54	GRK6	-0.0982570
55	NTRK3	-0.0954148
56	RPS6KA5	-0.0946511
57	LMTK2	-0.0934395
58	PRKCE	-0.0914827
59	EGFR	-0.0904433
60	TGFBR2	-0.0895683
61	PRKACG	-0.0886680
62	WEE1	-0.0848292
63	MAPK14	-0.0825177
64	LYN	-0.0823863
65	ROCK1	-0.0812887
66	AKT3	-0.0794081
67	EPHA4	-0.0792804
68	CAMK2A	-0.0777006
69	TTN	-0.0771133
70	MATK	-0.0756515
71	ADRBK1	-0.0749748
72	PHKG2	-0.0719409
73	PHKG1	-0.0719409
74	STK39	-0.0709929
75	CAMK1	-0.0697487
76	PIM2	-0.0696564
77	SYK	-0.0666102
78	KIT	-0.0627806
79	CDK2	-0.0624148
80	GRK5	-0.0568879
81	IRAK2	-0.0462306
82	FER	-0.0439747
83	BLK	-0.0427483
84	NEK6	-0.0420707
85	NME1	-0.0417851
86	ITK	-0.0285613
87	BTK	-0.0272807
88	PIK3CG	-0.0268279
89	SRC	-0.0218505
90	CDK3	-0.0212636
91	ERBB4	-0.0180633
92	PIM1	-0.0146529
93	AURKA	-0.0125103
94	PRKACA	-0.0101768
95	MST1R	-0.0078767
96	MAPK15	-0.0056114
97	ERBB2	-0.0039607
98	PAK3	-0.0032997
99	PRKCB	-0.0019740
100	TIE1	-0.0015898

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	8.53182443
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	7.01480321
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.27622158
4	RNA polymerase_Homo sapiens_hsa03020	3.18884121
5	Taste transduction_Homo sapiens_hsa04742	3.10927322
6	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.08882130
7	Lysine degradation_Homo sapiens_hsa00310	3.01403171
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.92538989
9	Fatty acid elongation_Homo sapiens_hsa00062	2.60011981
10	Butanoate metabolism_Homo sapiens_hsa00650	2.38213976
11	Glycerolipid metabolism_Homo sapiens_hsa00561	1.94645489
12	One carbon pool by folate_Homo sapiens_hsa00670	1.85141825
13	beta-Alanine metabolism_Homo sapiens_hsa00410	1.80352015
14	Amoebiasis_Homo sapiens_hsa05146	1.76907328
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.69820327
16	Proteasome_Homo sapiens_hsa03050	1.54233120
17	Propanoate metabolism_Homo sapiens_hsa00640	1.49061472
18	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.26059081
19	Viral myocarditis_Homo sapiens_hsa05416	1.07675879
20	Fatty acid degradation_Homo sapiens_hsa00071	1.04267166
21	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.97054094
22	Complement and coagulation cascades_Homo sapiens_hsa04610	0.96171371
23	Fatty acid metabolism_Homo sapiens_hsa01212	0.92530231
24	Caffeine metabolism_Homo sapiens_hsa00232	0.80283417
25	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.79593797
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.79476715
27	MicroRNAs in cancer_Homo sapiens_hsa05206	0.77871080
28	Peroxisome_Homo sapiens_hsa04146	0.77414556
29	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.73155827
30	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.72026108
31	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.71425210
32	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.69734899
33	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.68508986
34	AMPK signaling pathway_Homo sapiens_hsa04152	0.68014463
35	Phototransduction_Homo sapiens_hsa04744	0.60442400
36	Olfactory transduction_Homo sapiens_hsa04740	0.59086479
37	Salmonella infection_Homo sapiens_hsa05132	0.57989268
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.57523673
39	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.57360805
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.56921155
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56597186
42	Choline metabolism in cancer_Homo sapiens_hsa05231	0.56590343
43	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.54048364
44	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.51945020
45	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.51106634
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.51006880
47	Malaria_Homo sapiens_hsa05144	0.50561794
48	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.50325181
49	Linoleic acid metabolism_Homo sapiens_hsa00591	0.50074726
50	Retinol metabolism_Homo sapiens_hsa00830	0.49352890
51	Graft-versus-host disease_Homo sapiens_hsa05332	0.49022143
52	TNF signaling pathway_Homo sapiens_hsa04668	0.47251566
53	GnRH signaling pathway_Homo sapiens_hsa04912	0.46046813
54	Cholinergic synapse_Homo sapiens_hsa04725	0.45624450
55	Nicotine addiction_Homo sapiens_hsa05033	0.45328518
56	Nitrogen metabolism_Homo sapiens_hsa00910	0.44025792
57	Asthma_Homo sapiens_hsa05310	0.43338881
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41116357
59	Allograft rejection_Homo sapiens_hsa05330	0.39449901
60	Primary immunodeficiency_Homo sapiens_hsa05340	0.36672391
61	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.35044702
62	Nucleotide excision repair_Homo sapiens_hsa03420	0.34894787
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.33220902
64	Type I diabetes mellitus_Homo sapiens_hsa04940	0.32833051
65	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.32503875
66	Toxoplasmosis_Homo sapiens_hsa05145	0.30072913
67	Purine metabolism_Homo sapiens_hsa00230	0.28654558
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.28346791
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.27881248
70	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.27743151
71	RNA transport_Homo sapiens_hsa03013	0.27204302
72	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.26084556
73	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.23701592
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.23568232
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.23479551
76	ABC transporters_Homo sapiens_hsa02010	0.22865344
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.22818645
78	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.21656658
79	Protein digestion and absorption_Homo sapiens_hsa04974	0.20828080
80	African trypanosomiasis_Homo sapiens_hsa05143	0.20399036
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.20315179
82	ECM-receptor interaction_Homo sapiens_hsa04512	0.19754856
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.18594510
84	Tyrosine metabolism_Homo sapiens_hsa00350	0.17098494
85	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.16377055
86	Phagosome_Homo sapiens_hsa04145	0.15956774
87	Alcoholism_Homo sapiens_hsa05034	0.15735108
88	MAPK signaling pathway_Homo sapiens_hsa04010	0.13974606
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.13566147
90	Tuberculosis_Homo sapiens_hsa05152	0.13451068
91	Rap1 signaling pathway_Homo sapiens_hsa04015	0.13430641
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.12869702
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.11597455
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.11141053
95	Bile secretion_Homo sapiens_hsa04976	0.10248347
96	Renin-angiotensin system_Homo sapiens_hsa04614	0.09666033
97	Salivary secretion_Homo sapiens_hsa04970	0.09635794
98	Influenza A_Homo sapiens_hsa05164	0.05464716
99	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.05036771
100	Metabolic pathways_Homo sapiens_hsa01100	0.04544752

TAS2R63P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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