ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neural tube formation (GO:0001841)	5.44251678
2	monoubiquitinated protein deubiquitination (GO:0035520)	4.54487856
3	protein prenylation (GO:0018342)	4.42682951
4	prenylation (GO:0097354)	4.42682951
5	replication fork processing (GO:0031297)	4.25578127
6	DNA double-strand break processing (GO:0000729)	4.21234604
7	nuclear pore complex assembly (GO:0051292)	4.08886204
8	positive regulation of developmental pigmentation (GO:0048087)	4.07577894
9	regulation of pigment cell differentiation (GO:0050932)	4.04973554
10	protein K11-linked deubiquitination (GO:0035871)	3.99074509
11	presynaptic membrane assembly (GO:0097105)	3.88765601
12	regulation of centriole replication (GO:0046599)	3.80158151
13	nuclear pore organization (GO:0006999)	3.64488774
14	cell wall macromolecule catabolic process (GO:0016998)	3.62737424
15	histone mRNA catabolic process (GO:0071044)	3.52647901
16	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.48861565
17	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.48861565
18	regulation of translation, ncRNA-mediated (GO:0045974)	3.48861565
19	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.25661117
20	histone H2A acetylation (GO:0043968)	3.24690397
21	microtubule anchoring (GO:0034453)	3.24195507
22	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.23923919
23	pore complex assembly (GO:0046931)	3.21281794
24	mitotic sister chromatid cohesion (GO:0007064)	3.20786204
25	establishment of protein localization to Golgi (GO:0072600)	3.20720814
26	regulation of DNA endoreduplication (GO:0032875)	3.20369187
27	protein K48-linked deubiquitination (GO:0071108)	3.15294923
28	presynaptic membrane organization (GO:0097090)	3.13246770
29	retinal cone cell development (GO:0046549)	3.08182545
30	regulation of centrosome duplication (GO:0010824)	3.05665962
31	L-fucose catabolic process (GO:0042355)	2.98688733
32	fucose catabolic process (GO:0019317)	2.98688733
33	L-fucose metabolic process (GO:0042354)	2.98688733
34	resolution of meiotic recombination intermediates (GO:0000712)	2.98412801
35	response to pheromone (GO:0019236)	2.96678015
36	olfactory bulb development (GO:0021772)	2.96427644
37	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.93817318
38	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.92355908
39	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.92071441
40	cell wall macromolecule metabolic process (GO:0044036)	2.90379719
41	recombinational repair (GO:0000725)	2.89700825
42	double-strand break repair via homologous recombination (GO:0000724)	2.87796189
43	acrosome assembly (GO:0001675)	2.87694505
44	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.86039720
45	forebrain neuron differentiation (GO:0021879)	2.85981193
46	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.84655873
47	cellular response to ethanol (GO:0071361)	2.84258752
48	central nervous system neuron axonogenesis (GO:0021955)	2.83974714
49	translesion synthesis (GO:0019985)	2.82347971
50	pyrimidine nucleobase catabolic process (GO:0006208)	2.82161477
51	non-recombinational repair (GO:0000726)	2.81131713
52	double-strand break repair via nonhomologous end joining (GO:0006303)	2.81131713
53	interkinetic nuclear migration (GO:0022027)	2.80624762
54	snRNA transcription (GO:0009301)	2.77130932
55	negative regulation of neurotransmitter transport (GO:0051589)	2.76347973
56	microtubule nucleation (GO:0007020)	2.73104471
57	limb bud formation (GO:0060174)	2.71635612
58	embryonic epithelial tube formation (GO:0001838)	2.69737788
59	sympathetic nervous system development (GO:0048485)	2.68402741
60	protein targeting to Golgi (GO:0000042)	2.66971463
61	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.66594141
62	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.66594141
63	pericardium development (GO:0060039)	2.66359523
64	central nervous system projection neuron axonogenesis (GO:0021952)	2.66142582
65	regulation of establishment of cell polarity (GO:2000114)	2.66066404
66	negative regulation of DNA recombination (GO:0045910)	2.65322728
67	retinal rod cell development (GO:0046548)	2.64329236
68	anterograde synaptic vesicle transport (GO:0048490)	2.63984864
69	behavioral response to nicotine (GO:0035095)	2.62913490
70	regulation of development, heterochronic (GO:0040034)	2.62463494
71	response to X-ray (GO:0010165)	2.61328153
72	kinetochore organization (GO:0051383)	2.61048316
73	postreplication repair (GO:0006301)	2.60212764
74	cytoplasmic mRNA processing body assembly (GO:0033962)	2.59083605
75	behavioral response to ethanol (GO:0048149)	2.57062581
76	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.54746213
77	atrial cardiac muscle cell action potential (GO:0086014)	2.54333222
78	negative regulation of dendrite development (GO:2000171)	2.52772058
79	photoreceptor cell maintenance (GO:0045494)	2.50679077
80	protein K63-linked deubiquitination (GO:0070536)	2.49792952
81	epithelial tube formation (GO:0072175)	2.49415467
82	dorsal/ventral axis specification (GO:0009950)	2.48347032
83	Golgi to endosome transport (GO:0006895)	2.47836216
84	regulation of protein glycosylation (GO:0060049)	2.47671935
85	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.47648373
86	nucleus localization (GO:0051647)	2.47078579
87	regulation of centrosome cycle (GO:0046605)	2.46768583
88	kinetochore assembly (GO:0051382)	2.46686126
89	DNA integration (GO:0015074)	2.45791765
90	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.44715286
91	cilium morphogenesis (GO:0060271)	2.44389641
92	histone-serine phosphorylation (GO:0035404)	2.43745492
93	centriole replication (GO:0007099)	2.43727950
94	cellular response to sterol (GO:0036315)	2.42801348
95	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.41996788
96	regulation of timing of cell differentiation (GO:0048505)	2.40555404
97	protein localization to Golgi apparatus (GO:0034067)	2.40029329
98	positive regulation of mitochondrial fission (GO:0090141)	2.39986463
99	intraciliary transport (GO:0042073)	2.39692657
100	reciprocal DNA recombination (GO:0035825)	2.39534255

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.81884011
2	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.14005929
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.02161580
4	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	3.02161264
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.83004505
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.70396753
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.63850227
8	FUS_26573619_Chip-Seq_HEK293_Human	2.61970870
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.59439213
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.58638494
11	EWS_26573619_Chip-Seq_HEK293_Human	2.51890112
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.50803543
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.46115050
14	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.40595200
15	VDR_22108803_ChIP-Seq_LS180_Human	2.32635354
16	P300_19829295_ChIP-Seq_ESCs_Human	2.20491659
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.19591783
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.18864124
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.03281480
20	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.92951302
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.92550227
22	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.90352683
23	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.86630325
24	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.85979373
25	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.84890895
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.84124305
27	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.80937375
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.79990907
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.78274620
30	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.72050238
31	STAT3_23295773_ChIP-Seq_U87_Human	1.66178324
32	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.61832265
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.60378386
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.60020037
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.60020037
36	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.59749729
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58571983
38	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.58381824
39	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.53884907
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.53266976
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.52361750
42	ELK1_19687146_ChIP-ChIP_HELA_Human	1.51165788
43	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.50034733
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50019701
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.48227074
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47486178
47	GATA1_22025678_ChIP-Seq_K562_Human	1.46312192
48	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.45355952
49	TCF4_23295773_ChIP-Seq_U87_Human	1.43800322
50	AR_21572438_ChIP-Seq_LNCaP_Human	1.42992222
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40876655
52	AR_25329375_ChIP-Seq_VCAP_Human	1.40534801
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37390134
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37390134
55	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36222033
56	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.36081049
57	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.34469583
58	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.34451296
59	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.32942133
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32615746
61	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.29780828
62	TP53_16413492_ChIP-PET_HCT116_Human	1.28988779
63	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.28383466
64	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.28383466
65	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.27829315
66	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.27371864
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26181136
68	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.24685211
69	P53_22387025_ChIP-Seq_ESCs_Mouse	1.23680313
70	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.23503821
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22787686
72	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.22314367
73	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.21433666
74	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.19022798
75	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.17662345
76	E2F7_22180533_ChIP-Seq_HELA_Human	1.15653359
77	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.15290077
78	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.15087775
79	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.14894751
80	IRF1_19129219_ChIP-ChIP_H3396_Human	1.14789163
81	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.14353761
82	TCF4_22108803_ChIP-Seq_LS180_Human	1.12868809
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12122087
84	KDM2B_26808549_Chip-Seq_REH_Human	1.09947575
85	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.09681995
86	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.08246967
87	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07565118
88	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.07325997
89	P300_18555785_Chip-Seq_ESCs_Mouse	1.06971137
90	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.06629254
91	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.06290013
92	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05638565
93	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.05274247
94	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.04438760
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03558871
96	EZH2_22144423_ChIP-Seq_EOC_Human	1.03541347
97	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.03231947
98	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03036141
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.02663940
100	CDX2_22108803_ChIP-Seq_LS180_Human	1.02588442

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	5.53916325
2	MP0008057_abnormal_DNA_replication	3.95229115
3	MP0003890_abnormal_embryonic-extraembry	3.02117544
4	MP0005187_abnormal_penis_morphology	2.30046991
5	MP0010094_abnormal_chromosome_stability	2.17293041
6	MP0008058_abnormal_DNA_repair	2.08214396
7	MP0002102_abnormal_ear_morphology	2.06060495
8	MP0000427_abnormal_hair_cycle	2.02541559
9	MP0000372_irregular_coat_pigmentation	2.00188448
10	MP0003136_yellow_coat_color	1.99236654
11	MP0002638_abnormal_pupillary_reflex	1.96952513
12	MP0006054_spinal_hemorrhage	1.83715121
13	MP0003787_abnormal_imprinting	1.80183443
14	MP0008877_abnormal_DNA_methylation	1.72179042
15	MP0005174_abnormal_tail_pigmentation	1.70494561
16	MP0001984_abnormal_olfaction	1.69403964
17	MP0005253_abnormal_eye_physiology	1.65941453
18	MP0006072_abnormal_retinal_apoptosis	1.65802248
19	MP0002009_preneoplasia	1.65798182
20	MP0005551_abnormal_eye_electrophysiolog	1.63189132
21	MP0003121_genomic_imprinting	1.58324671
22	MP0010386_abnormal_urinary_bladder	1.57765629
23	MP0009046_muscle_twitch	1.56262293
24	MP0003880_abnormal_central_pattern	1.54487370
25	MP0005645_abnormal_hypothalamus_physiol	1.51473539
26	MP0000778_abnormal_nervous_system	1.49771955
27	MP0008995_early_reproductive_senescence	1.48932056
28	MP0002751_abnormal_autonomic_nervous	1.45997374
29	MP0006292_abnormal_olfactory_placode	1.44126521
30	MP0002254_reproductive_system_inflammat	1.40885972
31	MP0003786_premature_aging	1.39682561
32	MP0000631_abnormal_neuroendocrine_gland	1.38658622
33	MP0000647_abnormal_sebaceous_gland	1.37401693
34	MP0004924_abnormal_behavior	1.37112193
35	MP0005386_behavior/neurological_phenoty	1.37112193
36	MP0002234_abnormal_pharynx_morphology	1.33557104
37	MP0002938_white_spotting	1.31435876
38	MP0005075_abnormal_melanosome_morpholog	1.29237997
39	MP0001299_abnormal_eye_distance/	1.28779474
40	MP0002837_dystrophic_cardiac_calcinosis	1.28321247
41	MP0002928_abnormal_bile_duct	1.27962172
42	MP0003937_abnormal_limbs/digits/tail_de	1.27775240
43	MP0002909_abnormal_adrenal_gland	1.26475249
44	MP0002160_abnormal_reproductive_system	1.22653836
45	MP0009697_abnormal_copulation	1.18519209
46	MP0002233_abnormal_nose_morphology	1.16629940
47	MP0000383_abnormal_hair_follicle	1.16100978
48	MP0002822_catalepsy	1.15117060
49	MP0010678_abnormal_skin_adnexa	1.14959010
50	MP0002272_abnormal_nervous_system	1.14630370
51	MP0010307_abnormal_tumor_latency	1.13220442
52	MP0003868_abnormal_feces_composition	1.10986530
53	MP0001485_abnormal_pinna_reflex	1.10729269
54	MP0004484_altered_response_of	1.08375738
55	MP0008007_abnormal_cellular_replicative	1.08278791
56	MP0000371_diluted_coat_color	1.07196898
57	MP0002090_abnormal_vision	1.06522390
58	MP0005408_hypopigmentation	1.06124380
59	MP0009745_abnormal_behavioral_response	1.05788112
60	MP0004134_abnormal_chest_morphology	1.05407472
61	MP0004133_heterotaxia	1.05136900
62	MP0005195_abnormal_posterior_eye	1.05099098
63	MP0003646_muscle_fatigue	1.02192782
64	MP0001486_abnormal_startle_reflex	1.01879805
65	MP0000538_abnormal_urinary_bladder	1.01244066
66	MP0004142_abnormal_muscle_tone	1.00696212
67	MP0004043_abnormal_pH_regulation	0.99290437
68	MP0004084_abnormal_cardiac_muscle	0.97991769
69	MP0005367_renal/urinary_system_phenotyp	0.96872959
70	MP0000516_abnormal_urinary_system	0.96872959
71	MP0001324_abnormal_eye_pigmentation	0.96780603
72	MP0005391_vision/eye_phenotype	0.95810049
73	MP0001293_anophthalmia	0.95786753
74	MP0000015_abnormal_ear_pigmentation	0.95533260
75	MP0003252_abnormal_bile_duct	0.94821795
76	MP0002736_abnormal_nociception_after	0.94593611
77	MP0004215_abnormal_myocardial_fiber	0.93387517
78	MP0001529_abnormal_vocalization	0.91583026
79	MP0001286_abnormal_eye_development	0.90979836
80	MP0003221_abnormal_cardiomyocyte_apopto	0.90676616
81	MP0001929_abnormal_gametogenesis	0.88706337
82	MP0002557_abnormal_social/conspecific_i	0.84582900
83	MP0003195_calcinosis	0.83712843
84	MP0005248_abnormal_Harderian_gland	0.82885543
85	MP0003935_abnormal_craniofacial_develop	0.82810169
86	MP0002095_abnormal_skin_pigmentation	0.81211186
87	MP0002067_abnormal_sensory_capabilities	0.81205792
88	MP0002177_abnormal_outer_ear	0.81096226
89	MP0005389_reproductive_system_phenotype	0.79215806
90	MP0002168_other_aberrant_phenotype	0.78694221
91	MP0003077_abnormal_cell_cycle	0.78361690
92	MP0004381_abnormal_hair_follicle	0.78306407
93	MP0002735_abnormal_chemical_nociception	0.77238945
94	MP0003950_abnormal_plasma_membrane	0.77195086
95	MP0001968_abnormal_touch/_nociception	0.76457394
96	MP0002184_abnormal_innervation	0.74981635
97	MP0003755_abnormal_palate_morphology	0.74847933
98	MP0001119_abnormal_female_reproductive	0.73946115
99	MP0010352_gastrointestinal_tract_polyps	0.73639085
100	MP0005266_abnormal_metabolism	0.73469098

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Papillary thyroid carcinoma (HP:0002895)	3.63449356
2	Intestinal atresia (HP:0011100)	3.60832544
3	Abnormality of chromosome stability (HP:0003220)	3.58232149
4	Chronic hepatic failure (HP:0100626)	3.28890657
5	Hyperventilation (HP:0002883)	3.04183413
6	Tubulointerstitial nephritis (HP:0001970)	2.92223214
7	Pancreatic cysts (HP:0001737)	2.89840138
8	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.86910983
9	Gaze-evoked nystagmus (HP:0000640)	2.86800750
10	Pancreatic fibrosis (HP:0100732)	2.85121277
11	Thyroid carcinoma (HP:0002890)	2.75007796
12	True hermaphroditism (HP:0010459)	2.72272586
13	Glioma (HP:0009733)	2.70074419
14	Volvulus (HP:0002580)	2.68637440
15	Thyroiditis (HP:0100646)	2.65769355
16	Aqueductal stenosis (HP:0002410)	2.61704354
17	Bifid tongue (HP:0010297)	2.61492292
18	Medulloblastoma (HP:0002885)	2.58003940
19	Drooling (HP:0002307)	2.57177716
20	Oligodactyly (hands) (HP:0001180)	2.48278654
21	Abnormality of the renal cortex (HP:0011035)	2.47723490
22	Progressive inability to walk (HP:0002505)	2.43213864
23	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.42577439
24	Molar tooth sign on MRI (HP:0002419)	2.41318874
25	Abnormality of midbrain morphology (HP:0002418)	2.41318874
26	Febrile seizures (HP:0002373)	2.35457973
27	Cupped ear (HP:0000378)	2.34262437
28	Meckel diverticulum (HP:0002245)	2.33674374
29	Abnormality of the ileum (HP:0001549)	2.33418717
30	Excessive salivation (HP:0003781)	2.31076409
31	Hip dysplasia (HP:0001385)	2.29748165
32	Fair hair (HP:0002286)	2.28096326
33	Astrocytoma (HP:0009592)	2.28069199
34	Abnormality of the astrocytes (HP:0100707)	2.28069199
35	Rhabdomyosarcoma (HP:0002859)	2.27422481
36	Sloping forehead (HP:0000340)	2.25118667
37	Small hand (HP:0200055)	2.25088964
38	Hypoplastic labia majora (HP:0000059)	2.19484438
39	Submucous cleft hard palate (HP:0000176)	2.19249480
40	Gastrointestinal atresia (HP:0002589)	2.18566726
41	Clubbing of toes (HP:0100760)	2.16598082
42	Renal cortical cysts (HP:0000803)	2.15396808
43	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.12539065
44	Tubulointerstitial abnormality (HP:0001969)	2.09128403
45	Medial flaring of the eyebrow (HP:0010747)	2.08005150
46	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.06829980
47	Midline defect of the nose (HP:0004122)	2.05935852
48	Abnormality of the renal medulla (HP:0100957)	2.05840994
49	Chromsome breakage (HP:0040012)	2.04999228
50	Attenuation of retinal blood vessels (HP:0007843)	2.03983007
51	Abnormality of the labia majora (HP:0012881)	2.03559445
52	Neoplasm of striated muscle (HP:0009728)	2.03154218
53	Hepatoblastoma (HP:0002884)	2.02878430
54	Curly hair (HP:0002212)	2.02624989
55	Depressed nasal tip (HP:0000437)	2.00427035
56	Renal hypoplasia (HP:0000089)	2.00016895
57	Abnormality of the duodenum (HP:0002246)	1.96505936
58	Nephronophthisis (HP:0000090)	1.96285424
59	Chorioretinal atrophy (HP:0000533)	1.95257160
60	Widely spaced teeth (HP:0000687)	1.93379117
61	Supernumerary spleens (HP:0009799)	1.92981528
62	Astigmatism (HP:0000483)	1.91182188
63	Abnormality of the preputium (HP:0100587)	1.90769849
64	Colon cancer (HP:0003003)	1.89815426
65	Broad-based gait (HP:0002136)	1.88423060
66	Hypoplastic iliac wings (HP:0002866)	1.87813022
67	Increased number of teeth (HP:0011069)	1.85134870
68	Genital tract atresia (HP:0001827)	1.84719269
69	Neoplasm of the adrenal cortex (HP:0100641)	1.82947191
70	Albinism (HP:0001022)	1.82122081
71	Abnormality of the labia minora (HP:0012880)	1.81789241
72	Abnormality of alanine metabolism (HP:0010916)	1.81748057
73	Hyperalaninemia (HP:0003348)	1.81748057
74	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.81748057
75	Labial hypoplasia (HP:0000066)	1.81546136
76	Poor coordination (HP:0002370)	1.80557126
77	Tubular atrophy (HP:0000092)	1.76934254
78	Progressive cerebellar ataxia (HP:0002073)	1.76451910
79	Pheochromocytoma (HP:0002666)	1.74348931
80	Abnormality of the nasal septum (HP:0000419)	1.73799701
81	Large earlobe (HP:0009748)	1.73067444
82	Nephrogenic diabetes insipidus (HP:0009806)	1.72846103
83	Short tibia (HP:0005736)	1.72425380
84	Congenital hepatic fibrosis (HP:0002612)	1.72163688
85	Vaginal atresia (HP:0000148)	1.71759087
86	Neoplasm of the oral cavity (HP:0100649)	1.70426114
87	Preaxial hand polydactyly (HP:0001177)	1.68747317
88	Postaxial foot polydactyly (HP:0001830)	1.68103268
89	Congenital primary aphakia (HP:0007707)	1.67263370
90	Duodenal stenosis (HP:0100867)	1.67138721
91	Small intestinal stenosis (HP:0012848)	1.67138721
92	Hypoplastic female external genitalia (HP:0012815)	1.66172708
93	Oculomotor apraxia (HP:0000657)	1.65938257
94	Abnormality of the ischium (HP:0003174)	1.65929716
95	Protruding tongue (HP:0010808)	1.65744479
96	Gait imbalance (HP:0002141)	1.64705492
97	Narrow palate (HP:0000189)	1.63422811
98	Central scotoma (HP:0000603)	1.62663607
99	Generalized hypopigmentation of hair (HP:0011358)	1.62571531
100	Intellectual disability, moderate (HP:0002342)	1.56825813

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.80488791
2	TRIM28	3.18345775
3	BRSK2	3.02498335
4	MAP4K2	3.01344764
5	ACVR1B	2.81711821
6	BMPR1B	2.55403857
7	BCR	2.21120591
8	NUAK1	2.10773618
9	AKT3	2.02162086
10	MKNK2	1.92998724
11	CAMKK2	1.89211758
12	MAPK13	1.69548858
13	ZAK	1.64145095
14	CASK	1.61702708
15	STK39	1.60006021
16	TNIK	1.52600615
17	WNK3	1.51326506
18	MAP3K4	1.50930012
19	PLK2	1.50920370
20	ERBB3	1.48528016
21	PAK3	1.41603174
22	FGFR2	1.39389971
23	PLK4	1.27493414
24	NLK	1.22802739
25	EPHA4	1.21324662
26	RPS6KA4	1.19627292
27	INSRR	1.18208158
28	OBSCN	1.16586198
29	PNCK	1.16436014
30	OXSR1	1.16184195
31	PINK1	1.15167624
32	BRD4	1.14950406
33	PLK3	1.09530567
34	MKNK1	1.07093001
35	EIF2AK3	1.05279293
36	SGK2	1.02931185
37	ADRBK2	0.95940901
38	STK38L	0.94278692
39	CAMK1G	0.93002179
40	CCNB1	0.92997475
41	PDK2	0.91896656
42	EPHA3	0.89333210
43	SRPK1	0.88568734
44	NEK1	0.86853251
45	IRAK1	0.83741482
46	TGFBR1	0.81994893
47	TAF1	0.78755592
48	STK24	0.78014461
49	MUSK	0.76999524
50	PKN1	0.76689807
51	BRSK1	0.75958222
52	CSNK1G1	0.74089350
53	PIK3CG	0.74049604
54	GRK1	0.73667018
55	VRK1	0.70245292
56	ERBB4	0.69606024
57	PRKCE	0.67718335
58	ATM	0.67517407
59	TEC	0.65350974
60	BUB1	0.64856772
61	FGFR3	0.64756178
62	CDK8	0.62434319
63	TSSK6	0.61449023
64	LATS1	0.60893365
65	RAF1	0.59624410
66	KSR1	0.58983664
67	WEE1	0.58305700
68	PIK3CA	0.57852237
69	CDC7	0.57481810
70	MARK1	0.57315600
71	ATR	0.56510698
72	CDK3	0.55457348
73	DYRK1A	0.54888799
74	CAMK1D	0.54183392
75	CSNK1G2	0.52522531
76	RPS6KA5	0.51710647
77	CAMK4	0.51026295
78	FER	0.48954725
79	CSNK1A1L	0.48648236
80	FGFR1	0.46650886
81	STK3	0.46616332
82	NTRK2	0.46478613
83	SIK3	0.46447029
84	DYRK3	0.45305013
85	MELK	0.44375567
86	PLK1	0.43463710
87	MINK1	0.42560566
88	MAP3K7	0.41716953
89	SGK223	0.41600519
90	SGK494	0.41600519
91	NEK6	0.40664303
92	MST4	0.39821248
93	ERBB2	0.39565027
94	PBK	0.39340744
95	MAP2K7	0.38725702
96	CHEK2	0.38006076
97	SGK3	0.37193570
98	CSNK1D	0.36107454
99	TLK1	0.36007384
100	DMPK	0.35761252

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	4.63967731
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.59340746
3	Basal transcription factors_Homo sapiens_hsa03022	2.37386554
4	Taste transduction_Homo sapiens_hsa04742	2.32530056
5	Homologous recombination_Homo sapiens_hsa03440	2.30919873
6	Propanoate metabolism_Homo sapiens_hsa00640	2.30522984
7	Protein export_Homo sapiens_hsa03060	2.23883707
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.21306956
9	Butanoate metabolism_Homo sapiens_hsa00650	2.20172128
10	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.17082500
11	Nicotine addiction_Homo sapiens_hsa05033	1.98480825
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.84810349
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.81078110
14	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.73170481
15	RNA degradation_Homo sapiens_hsa03018	1.72061884
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.67343926
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.61784539
18	Lysine degradation_Homo sapiens_hsa00310	1.58930243
19	Circadian rhythm_Homo sapiens_hsa04710	1.56625871
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.45655668
21	Phototransduction_Homo sapiens_hsa04744	1.43640649
22	Glutamatergic synapse_Homo sapiens_hsa04724	1.36293044
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.30959062
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.30536627
25	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.29315719
26	Alcoholism_Homo sapiens_hsa05034	1.26494704
27	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.26456591
28	Caffeine metabolism_Homo sapiens_hsa00232	1.22745296
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.22389240
30	Mismatch repair_Homo sapiens_hsa03430	1.22100936
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.16918997
32	Cell cycle_Homo sapiens_hsa04110	1.14992780
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.12983587
34	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.12146290
35	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.09163616
36	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.06289237
37	Ether lipid metabolism_Homo sapiens_hsa00565	1.04997219
38	Olfactory transduction_Homo sapiens_hsa04740	1.04981677
39	Linoleic acid metabolism_Homo sapiens_hsa00591	1.03324177
40	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.01051392
41	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.00055595
42	GABAergic synapse_Homo sapiens_hsa04727	0.98152631
43	Long-term depression_Homo sapiens_hsa04730	0.96820667
44	Steroid biosynthesis_Homo sapiens_hsa00100	0.96797222
45	Morphine addiction_Homo sapiens_hsa05032	0.95129957
46	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.94528969
47	Regulation of autophagy_Homo sapiens_hsa04140	0.94514080
48	Circadian entrainment_Homo sapiens_hsa04713	0.94219683
49	Melanoma_Homo sapiens_hsa05218	0.88526392
50	Nitrogen metabolism_Homo sapiens_hsa00910	0.86724583
51	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.84525963
52	RNA polymerase_Homo sapiens_hsa03020	0.82647746
53	p53 signaling pathway_Homo sapiens_hsa04115	0.80476022
54	Oocyte meiosis_Homo sapiens_hsa04114	0.79206859
55	Cholinergic synapse_Homo sapiens_hsa04725	0.78781325
56	MicroRNAs in cancer_Homo sapiens_hsa05206	0.77961013
57	ABC transporters_Homo sapiens_hsa02010	0.77492985
58	Dopaminergic synapse_Homo sapiens_hsa04728	0.76292731
59	FoxO signaling pathway_Homo sapiens_hsa04068	0.73852578
60	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.73018172
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71845064
62	RNA transport_Homo sapiens_hsa03013	0.71768739
63	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.70893641
64	Serotonergic synapse_Homo sapiens_hsa04726	0.69577413
65	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.68641863
66	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.68451885
67	DNA replication_Homo sapiens_hsa03030	0.67893752
68	Renin secretion_Homo sapiens_hsa04924	0.67594734
69	Colorectal cancer_Homo sapiens_hsa05210	0.66603964
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.65360487
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.63692279
72	cAMP signaling pathway_Homo sapiens_hsa04024	0.63357916
73	One carbon pool by folate_Homo sapiens_hsa00670	0.60510903
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.55515441
75	Calcium signaling pathway_Homo sapiens_hsa04020	0.55235476
76	Prostate cancer_Homo sapiens_hsa05215	0.52875423
77	Tryptophan metabolism_Homo sapiens_hsa00380	0.50362057
78	Peroxisome_Homo sapiens_hsa04146	0.50067600
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48628498
80	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.48133505
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.47365279
82	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.45598638
83	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.45091165
84	Amphetamine addiction_Homo sapiens_hsa05031	0.44624295
85	Choline metabolism in cancer_Homo sapiens_hsa05231	0.43024945
86	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.42622153
87	Purine metabolism_Homo sapiens_hsa00230	0.42099328
88	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.40351980
89	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.40186665
90	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.39561613
91	Wnt signaling pathway_Homo sapiens_hsa04310	0.39121184
92	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.39089902
93	Hippo signaling pathway_Homo sapiens_hsa04390	0.35999849
94	Adherens junction_Homo sapiens_hsa04520	0.35302448
95	Salivary secretion_Homo sapiens_hsa04970	0.34777174
96	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.31938996
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.30115240
98	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.29930698
99	Retinol metabolism_Homo sapiens_hsa00830	0.28447630
100	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28054597

TAS2R64P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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