TAS2R6P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chemosensory behavior (GO:0007635)9.37482613
2spermatid nucleus differentiation (GO:0007289)5.74024128
3detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)5.46295247
4mitochondrial DNA metabolic process (GO:0032042)4.89524408
5detection of chemical stimulus involved in sensory perception of taste (GO:0050912)4.75438423
6retinal rod cell development (GO:0046548)4.49528094
7tRNA aminoacylation for protein translation (GO:0006418)4.48821851
8amino acid activation (GO:0043038)4.40426524
9tRNA aminoacylation (GO:0043039)4.40426524
10nuclear pore complex assembly (GO:0051292)4.26440349
11mitochondrial DNA replication (GO:0006264)4.19975846
12RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.18810985
13L-serine metabolic process (GO:0006563)4.06382411
14glucose 6-phosphate metabolic process (GO:0051156)4.06232843
15retinal cone cell development (GO:0046549)4.05557132
16mitotic sister chromatid cohesion (GO:0007064)4.04283306
17DNA strand elongation involved in DNA replication (GO:0006271)3.98607798
18DNA strand elongation (GO:0022616)3.79132524
19sensory perception of taste (GO:0050909)3.78014188
20negative regulation of DNA recombination (GO:0045910)3.77882972
21ER overload response (GO:0006983)3.76970144
22succinate metabolic process (GO:0006105)3.76729995
23regulation of mitotic spindle organization (GO:0060236)3.74171644
24chromatin remodeling at centromere (GO:0031055)3.72338356
25CENP-A containing nucleosome assembly (GO:0034080)3.67188013
26embryonic retina morphogenesis in camera-type eye (GO:0060059)3.66028473
27acrosome assembly (GO:0001675)3.63565915
28gluconeogenesis (GO:0006094)3.61249563
29nuclear pore organization (GO:0006999)3.59422698
30histone mRNA catabolic process (GO:0071044)3.59060674
31telomere maintenance via semi-conservative replication (GO:0032201)3.57980938
32spindle checkpoint (GO:0031577)3.57175886
33negative regulation of mitotic sister chromatid separation (GO:2000816)3.55547588
34negative regulation of sister chromatid segregation (GO:0033046)3.55547588
35negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.55547588
36negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.55547588
37negative regulation of mitotic sister chromatid segregation (GO:0033048)3.55547588
38glycolytic process (GO:0006096)3.54351735
39protein localization to kinetochore (GO:0034501)3.54292675
40mitotic spindle checkpoint (GO:0071174)3.54127098
41hexose biosynthetic process (GO:0019319)3.49493976
42cullin deneddylation (GO:0010388)3.46977546
43negative regulation of chromosome segregation (GO:0051985)3.46149192
44DNA strand renaturation (GO:0000733)3.44997982
45regulation of centriole replication (GO:0046599)3.44159929
46telomere maintenance via recombination (GO:0000722)3.43446990
47histone exchange (GO:0043486)3.41394180
48DNA replication checkpoint (GO:0000076)3.40547509
49non-recombinational repair (GO:0000726)3.39672670
50double-strand break repair via nonhomologous end joining (GO:0006303)3.39672670
51inner cell mass cell proliferation (GO:0001833)3.36532039
52mitotic G2/M transition checkpoint (GO:0044818)3.31767308
53regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.31269890
54regulation of mitotic spindle checkpoint (GO:1903504)3.31269890
55regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.27209896
56regulation of mitotic metaphase/anaphase transition (GO:0030071)3.27209896
57protein K11-linked deubiquitination (GO:0035871)3.27140587
58DNA ligation (GO:0006266)3.25036624
59mitotic recombination (GO:0006312)3.24362567
60mitotic nuclear envelope disassembly (GO:0007077)3.24230062
61monosaccharide biosynthetic process (GO:0046364)3.23615187
62regulation of mitotic sister chromatid separation (GO:0010965)3.21488376
63regulation of mitotic sister chromatid segregation (GO:0033047)3.21488376
64regulation of sister chromatid segregation (GO:0033045)3.21488376
65L-alpha-amino acid transmembrane transport (GO:1902475)3.20979970
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.18414765
67aldehyde catabolic process (GO:0046185)3.18126361
68attachment of spindle microtubules to kinetochore (GO:0008608)3.16178693
69mitotic G2 DNA damage checkpoint (GO:0007095)3.15860027
70mitotic sister chromatid segregation (GO:0000070)3.15167649
71sister chromatid segregation (GO:0000819)3.13007523
72protein deneddylation (GO:0000338)3.12749306
73spindle assembly checkpoint (GO:0071173)3.12422781
74neural tube formation (GO:0001841)3.11556805
75regulation of spindle organization (GO:0090224)3.09925735
76DNA replication initiation (GO:0006270)3.09394451
77response to nitrosative stress (GO:0051409)3.08991566
78pore complex assembly (GO:0046931)3.08738828
79formation of translation preinitiation complex (GO:0001731)3.08223521
80DNA unwinding involved in DNA replication (GO:0006268)3.07314687
81histone H2A acetylation (GO:0043968)3.04656573
82membrane disassembly (GO:0030397)3.03259274
83nuclear envelope disassembly (GO:0051081)3.03259274
84DNA damage response, detection of DNA damage (GO:0042769)3.01707414
85poly(A)+ mRNA export from nucleus (GO:0016973)3.00645458
86mitotic spindle assembly checkpoint (GO:0007094)2.99782927
87nonmotile primary cilium assembly (GO:0035058)2.99228873
88endosome to pigment granule transport (GO:0043485)2.98584916
89endosome to melanosome transport (GO:0035646)2.98584916
90fructose metabolic process (GO:0006000)2.98222030
91maintenance of protein location in nucleus (GO:0051457)2.96753337
92replication fork processing (GO:0031297)2.95818368
93regulation of translational fidelity (GO:0006450)2.95340516
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93669205
95IMP biosynthetic process (GO:0006188)2.93417745
96negative regulation of histone acetylation (GO:0035067)2.92948519
97DNA replication-independent nucleosome assembly (GO:0006336)2.91677404
98DNA replication-independent nucleosome organization (GO:0034724)2.91677404
99DNA double-strand break processing (GO:0000729)2.89914274
100DNA catabolic process, exonucleolytic (GO:0000738)2.86880620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.00148469
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.04706317
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.73446221
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.66885582
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.19683243
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.10697291
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.96896138
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.94550862
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.94313580
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.79109441
11ELK1_19687146_ChIP-ChIP_HELA_Human2.76546150
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.67753262
13PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.49393598
14ZNF274_21170338_ChIP-Seq_K562_Hela2.25433128
15VDR_23849224_ChIP-Seq_CD4+_Human2.15196800
16FOXP3_21729870_ChIP-Seq_TREG_Human2.13824754
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.10020041
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08816648
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.97851937
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93844393
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.92387894
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91487300
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90990034
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89451738
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82597683
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82487402
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.80135648
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75049260
29DCP1A_22483619_ChIP-Seq_HELA_Human1.70166107
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.69164263
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67944204
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57523603
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56247722
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55483694
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.54684612
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52668376
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51444763
38GATA1_22025678_ChIP-Seq_K562_Human1.49795228
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.47214637
40AR_21909140_ChIP-Seq_LNCAP_Human1.46974210
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46643327
42IGF1R_20145208_ChIP-Seq_DFB_Human1.46043237
43VDR_22108803_ChIP-Seq_LS180_Human1.45174956
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43244042
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42875491
46EWS_26573619_Chip-Seq_HEK293_Human1.42660568
47GABP_19822575_ChIP-Seq_HepG2_Human1.41181166
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40712090
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36571185
50TAF15_26573619_Chip-Seq_HEK293_Human1.34699639
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31290589
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29156565
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25575696
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22172571
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21454659
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.16070240
57CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13511904
58TTF2_22483619_ChIP-Seq_HELA_Human1.11969523
59MYC_18940864_ChIP-ChIP_HL60_Human1.11271300
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09921734
61KDM5A_27292631_Chip-Seq_BREAST_Human1.09610457
62XRN2_22483619_ChIP-Seq_HELA_Human1.08915780
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08802705
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07960746
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05028328
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00391351
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98446226
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98426858
69FUS_26573619_Chip-Seq_HEK293_Human0.97723172
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94020671
71ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93820335
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92406001
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91513663
74CDX2_22108803_ChIP-Seq_LS180_Human0.91495713
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91020827
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90659895
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90164470
78FLI1_27457419_Chip-Seq_LIVER_Mouse0.89760282
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88532428
80P300_19829295_ChIP-Seq_ESCs_Human0.88507740
81ELK1_22589737_ChIP-Seq_MCF10A_Human0.87791642
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87686422
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85580448
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.85267355
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85250574
86CRX_20693478_ChIP-Seq_RETINA_Mouse0.85170499
87CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85066714
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84663251
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84391782
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84287710
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82722766
92STAT3_23295773_ChIP-Seq_U87_Human0.81795910
93FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81680871
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.80235448
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.78863229
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.78595566
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78224864
98PIAS1_25552417_ChIP-Seq_VCAP_Human0.77930293
99SALL4_22934838_ChIP-ChIP_CD34+_Human0.76581668
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76091027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.80602041
2MP0008007_abnormal_cellular_replicative4.58704821
3MP0010094_abnormal_chromosome_stability4.15804303
4MP0008058_abnormal_DNA_repair3.49054621
5MP0003077_abnormal_cell_cycle3.15272841
6MP0003111_abnormal_nucleus_morphology3.03082039
7MP0002009_preneoplasia2.76578036
8MP0003195_calcinosis2.50402764
9MP0009697_abnormal_copulation2.49506911
10MP0004957_abnormal_blastocyst_morpholog2.45522836
11MP0003786_premature_aging2.32939140
12MP0008932_abnormal_embryonic_tissue2.26432819
13MP0003656_abnormal_erythrocyte_physiolo2.24935574
14MP0001529_abnormal_vocalization2.19283519
15MP0006292_abnormal_olfactory_placode2.16142919
16MP0004147_increased_porphyrin_level2.09051896
17MP0003693_abnormal_embryo_hatching2.08488541
18MP0003122_maternal_imprinting1.86691803
19MP0003567_abnormal_fetal_cardiomyocyte1.84298660
20MP0000566_synostosis1.82329705
21MP0000579_abnormal_nail_morphology1.76007624
22MP0000647_abnormal_sebaceous_gland1.75876421
23MP0002938_white_spotting1.73427607
24MP0006035_abnormal_mitochondrial_morpho1.65479527
25MP0010307_abnormal_tumor_latency1.61666475
26MP0002132_abnormal_respiratory_system1.48969830
27MP0002090_abnormal_vision1.45192176
28MP0001764_abnormal_homeostasis1.41433699
29MP0001697_abnormal_embryo_size1.39757070
30MP0004264_abnormal_extraembryonic_tissu1.34153487
31MP0000427_abnormal_hair_cycle1.33510631
32MP0003252_abnormal_bile_duct1.33284104
33MP0005451_abnormal_body_composition1.32740523
34MP0010352_gastrointestinal_tract_polyps1.29721447
35MP0001929_abnormal_gametogenesis1.29628879
36MP0001672_abnormal_embryogenesis/_devel1.27657330
37MP0005380_embryogenesis_phenotype1.27657330
38MP0010329_abnormal_lipoprotein_level1.26948565
39MP0002751_abnormal_autonomic_nervous1.24164216
40MP0005174_abnormal_tail_pigmentation1.22987305
41MP0003937_abnormal_limbs/digits/tail_de1.22257151
42MP0003984_embryonic_growth_retardation1.14134412
43MP0008877_abnormal_DNA_methylation1.14121817
44MP0001324_abnormal_eye_pigmentation1.12322811
45MP0002088_abnormal_embryonic_growth/wei1.12173861
46MP0009703_decreased_birth_body1.09144128
47MP0002095_abnormal_skin_pigmentation1.08376739
48MP0005394_taste/olfaction_phenotype1.07849699
49MP0005499_abnormal_olfactory_system1.07849699
50MP0002080_prenatal_lethality1.07669164
51MP0000350_abnormal_cell_proliferation1.06495916
52MP0008789_abnormal_olfactory_epithelium1.05843441
53MP0001293_anophthalmia1.03835366
54MP0001730_embryonic_growth_arrest1.02979315
55MP0004197_abnormal_fetal_growth/weight/1.02763772
56MP0003183_abnormal_peptide_metabolism1.01687802
57MP0003941_abnormal_skin_development1.00019800
58MP0002084_abnormal_developmental_patter0.98207774
59MP0005266_abnormal_metabolism0.97588453
60MP0005408_hypopigmentation0.91715581
61MP0005171_absent_coat_pigmentation0.91135629
62MP0009672_abnormal_birth_weight0.90621013
63MP0002160_abnormal_reproductive_system0.88887562
64MP0005253_abnormal_eye_physiology0.87640463
65MP0005310_abnormal_salivary_gland0.84483061
66MP0003806_abnormal_nucleotide_metabolis0.83809131
67MP0002086_abnormal_extraembryonic_tissu0.82656817
68MP0003121_genomic_imprinting0.80906606
69MP0000358_abnormal_cell_content/0.80741311
70MP0001661_extended_life_span0.80370649
71MP0003698_abnormal_male_reproductive0.79672344
72MP0002928_abnormal_bile_duct0.79122310
73MP0002085_abnormal_embryonic_tissue0.78654837
74MP0003221_abnormal_cardiomyocyte_apopto0.77719378
75MP0000653_abnormal_sex_gland0.77554247
76MP0002697_abnormal_eye_size0.77119845
77MP0004134_abnormal_chest_morphology0.76708902
78MP0008872_abnormal_physiological_respon0.74375325
79MP0002111_abnormal_tail_morphology0.74100366
80MP0009780_abnormal_chondrocyte_physiolo0.73242527
81MP0002127_abnormal_cardiovascular_syste0.72657969
82MP0005376_homeostasis/metabolism_phenot0.71962579
83MP0000313_abnormal_cell_death0.71666305
84MP0000383_abnormal_hair_follicle0.70686466
85MP0002210_abnormal_sex_determination0.70432614
86MP0002075_abnormal_coat/hair_pigmentati0.70262008
87MP0000015_abnormal_ear_pigmentation0.70192965
88MP0000569_abnormal_digit_pigmentation0.69468503
89MP0005551_abnormal_eye_electrophysiolog0.68173529
90MP0001145_abnormal_male_reproductive0.68096043
91MP0006072_abnormal_retinal_apoptosis0.67263503
92MP0002233_abnormal_nose_morphology0.67236596
93MP0010678_abnormal_skin_adnexa0.66410316
94MP0003890_abnormal_embryonic-extraembry0.66262110
95MP0002168_other_aberrant_phenotype0.66244342
96MP0003878_abnormal_ear_physiology0.64561195
97MP0005377_hearing/vestibular/ear_phenot0.64561195
98MP0005332_abnormal_amino_acid0.63252615
99MP0001286_abnormal_eye_development0.63055077
100MP0003283_abnormal_digestive_organ0.62652314

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)9.46916053
2Abnormal gallbladder physiology (HP:0012438)9.46916053
3Hypoplastic pelvis (HP:0008839)6.06660633
4Stenosis of the external auditory canal (HP:0000402)3.48883217
5Abnormal gallbladder morphology (HP:0012437)3.47233635
6Cholelithiasis (HP:0001081)3.39219070
7Neonatal respiratory distress (HP:0002643)3.32562077
8Abnormality of glycolysis (HP:0004366)3.31817315
9Rhabdomyosarcoma (HP:0002859)3.29039100
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.20118794
11Poor eye contact (HP:0000817)3.19831106
12Impaired proprioception (HP:0010831)3.12920988
13Colon cancer (HP:0003003)2.98874135
14Testicular atrophy (HP:0000029)2.90814905
15Postnatal microcephaly (HP:0005484)2.88541236
16Delayed puberty (HP:0000823)2.86410471
17Abnormality of chromosome stability (HP:0003220)2.84768289
18Prolonged partial thromboplastin time (HP:0003645)2.80935729
19Impaired social interactions (HP:0000735)2.72746323
20Abnormal social behavior (HP:0012433)2.72746323
21Abnormality of the metopic suture (HP:0005556)2.57873928
22Overlapping toe (HP:0001845)2.57838917
23Facial hemangioma (HP:0000329)2.56836773
24Chromsome breakage (HP:0040012)2.53758562
25Insidious onset (HP:0003587)2.47283496
26Termporal pattern (HP:0011008)2.47283496
27Homocystinuria (HP:0002156)2.46740642
28Abnormality of homocysteine metabolism (HP:0010919)2.46740642
29Abnormal lung lobation (HP:0002101)2.46107211
30Sloping forehead (HP:0000340)2.39477238
31Duodenal stenosis (HP:0100867)2.37945216
32Small intestinal stenosis (HP:0012848)2.37945216
33Meckel diverticulum (HP:0002245)2.34620877
34Abnormality of macular pigmentation (HP:0008002)2.32784844
35Increased density of long bones (HP:0006392)2.32613249
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.31568169
37Neoplasm of striated muscle (HP:0009728)2.24203359
38Neoplasm of the colon (HP:0100273)2.22871101
3911 pairs of ribs (HP:0000878)2.22748596
40Megaloblastic anemia (HP:0001889)2.22189626
41Adrenal hypoplasia (HP:0000835)2.21675340
42Progressive external ophthalmoplegia (HP:0000590)2.20800514
43Entropion (HP:0000621)2.17759527
44Ulnar claw (HP:0001178)2.16622375
45Abnormality of the ileum (HP:0001549)2.15484102
46Abnormality of the preputium (HP:0100587)2.12562094
47Decreased testicular size (HP:0008734)2.10910020
48Delayed epiphyseal ossification (HP:0002663)2.10710562
49Abnormality of endocrine pancreas physiology (HP:0012093)2.10506587
50Abnormality of the pancreatic islet cells (HP:0006476)2.10506587
51Abnormality of the duodenum (HP:0002246)2.10118920
52Abnormality of the gallbladder (HP:0005264)2.09822570
53Abnormality of the carotid arteries (HP:0005344)2.09119100
54Nephroblastoma (Wilms tumor) (HP:0002667)2.07425225
55Proximal amyotrophy (HP:0007126)2.04465613
56Abnormality of the musculature of the pelvis (HP:0001469)2.02889330
57Abnormality of the hip-girdle musculature (HP:0001445)2.02889330
58Hyperventilation (HP:0002883)2.02884564
59Prominent metopic ridge (HP:0005487)2.02396002
60Global brain atrophy (HP:0002283)1.98510555
61Dyschromatopsia (HP:0007641)1.98087984
62Oligodactyly (HP:0012165)1.96707782
63Embryonal renal neoplasm (HP:0011794)1.96665547
64Poor coordination (HP:0002370)1.96574714
65Abnormality of chromosome segregation (HP:0002916)1.96037946
66Medulloblastoma (HP:0002885)1.93348556
67Rib fusion (HP:0000902)1.92439530
68Congenital primary aphakia (HP:0007707)1.92388861
69Nephrogenic diabetes insipidus (HP:0009806)1.89390937
70Shoulder girdle muscle weakness (HP:0003547)1.88891618
71Pelvic girdle muscle weakness (HP:0003749)1.88577848
72Supernumerary spleens (HP:0009799)1.88480825
73Ectopic kidney (HP:0000086)1.87428364
74Acute hepatic failure (HP:0006554)1.87005188
75Diastasis recti (HP:0001540)1.86481089
76Abnormality of methionine metabolism (HP:0010901)1.85514490
77Hypobetalipoproteinemia (HP:0003563)1.84532998
78Poikiloderma (HP:0001029)1.83754530
79Upper limb muscle weakness (HP:0003484)1.83221493
80Oligodactyly (hands) (HP:0001180)1.83046987
81Anhidrosis (HP:0000970)1.82067711
82Chorioretinal coloboma (HP:0000567)1.79934177
83Duplicated collecting system (HP:0000081)1.79152719
84Hypogonadotrophic hypogonadism (HP:0000044)1.78744675
85Progressive inability to walk (HP:0002505)1.77604847
86Cone-rod dystrophy (HP:0000548)1.77012966
87Myelodysplasia (HP:0002863)1.76891873
88Abnormality of the intrinsic pathway (HP:0010989)1.76407669
89Gait imbalance (HP:0002141)1.76189144
90Hypoplastic female external genitalia (HP:0012815)1.75375154
91Hyperglycemia (HP:0003074)1.69964270
92Genital tract atresia (HP:0001827)1.69677202
93Retinal atrophy (HP:0001105)1.69351725
94Clubbing of toes (HP:0100760)1.69099708
95Progressive sensorineural hearing impairment (HP:0000408)1.68214068
96Labial hypoplasia (HP:0000066)1.66884411
97Vaginal atresia (HP:0000148)1.65184971
98Progressive hearing impairment (HP:0001730)1.63772393
99Missing ribs (HP:0000921)1.63127258
100Hypopigmentation of the fundus (HP:0007894)1.63103989

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.74197311
2BUB14.64412559
3TTK3.18911390
4MKNK23.11127068
5PASK2.94734632
6TSSK62.79304484
7TAOK32.70506953
8MKNK12.66103309
9NEK92.36576302
10WNK32.34617296
11EIF2AK32.18543663
12BRD42.15154535
13PLK42.15123583
14FRK2.09523963
15PLK32.08623566
16NEK11.97798509
17STK161.82200155
18NUAK11.79355046
19WEE11.79050124
20PLK11.76375411
21TNIK1.64190466
22STK391.59587844
23TRIM281.54916832
24BRSK21.49738903
25NLK1.40521361
26ATR1.39950356
27PDK21.33735563
28PLK21.33642834
29ZAK1.30464126
30PBK1.22858412
31FGFR21.22375599
32TRPM71.22268594
33ERBB31.21910262
34WNK41.12147412
35CDC71.10042859
36PIK3CA1.02421245
37CHEK10.98477990
38NEK20.98218398
39BCR0.96463881
40BRSK10.96312601
41ATM0.94443138
42FGFR10.93684701
43CASK0.88223893
44SRPK10.86830840
45RPS6KB10.85206107
46IRAK40.80766519
47AURKB0.80246116
48EIF2AK20.78061225
49OXSR10.74958353
50TGFBR10.73696417
51BMPR1B0.73412803
52IRAK20.72785260
53CDK120.72276428
54BMX0.71853291
55MARK10.68150776
56NEK60.67800611
57MST40.65303627
58MAP3K40.65244420
59MAP3K20.64752850
60MAP3K70.62775692
61YES10.62166300
62SIK20.61853888
63STK30.61567579
64CDK20.60630094
65CSNK1E0.59083145
66CDK10.58705318
67WNK10.57599667
68VRK10.56619395
69MELK0.55051596
70FGFR30.53027209
71IRAK10.51612921
72PRKDC0.51571178
73CAMK1D0.50979634
74SIK30.49930088
75CSNK1G10.47955515
76MTOR0.46310677
77CSNK2A20.41823893
78ERBB40.40561898
79CHEK20.39246561
80LATS10.39227071
81TNK20.37611828
82TEC0.32766913
83STK110.32028578
84DYRK1A0.31811147
85TAF10.30660088
86MAPK140.30358892
87PRKCG0.30295325
88FER0.30055778
89CLK10.29855113
90PRKAA10.29681002
91SGK10.28796923
92AKT10.28629940
93IGF1R0.28585535
94RPS6KB20.27403717
95DAPK10.27223487
96NTRK20.25673478
97ADRBK20.25658640
98SGK20.25619245
99CSNK2A10.24987307
100PAK30.24187196

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.66518028
2DNA replication_Homo sapiens_hsa030303.19803266
3Mismatch repair_Homo sapiens_hsa034303.17031171
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.02258006
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.92895945
6Base excision repair_Homo sapiens_hsa034102.62039343
7RNA degradation_Homo sapiens_hsa030182.60677352
8Propanoate metabolism_Homo sapiens_hsa006402.55188540
9Protein export_Homo sapiens_hsa030602.53794890
10One carbon pool by folate_Homo sapiens_hsa006702.45136801
11Nucleotide excision repair_Homo sapiens_hsa034202.38153438
12Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.37053782
13Biosynthesis of amino acids_Homo sapiens_hsa012302.25343519
14Taste transduction_Homo sapiens_hsa047422.24797830
15Vitamin B6 metabolism_Homo sapiens_hsa007502.22726502
16Fanconi anemia pathway_Homo sapiens_hsa034602.18786770
17Pentose phosphate pathway_Homo sapiens_hsa000302.12685145
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.11291896
19Fatty acid elongation_Homo sapiens_hsa000622.10636701
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.08677196
21RNA transport_Homo sapiens_hsa030132.06216765
22Carbon metabolism_Homo sapiens_hsa012001.88894014
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84442999
24Basal transcription factors_Homo sapiens_hsa030221.83021228
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.74956408
26Homologous recombination_Homo sapiens_hsa034401.72813883
27Butanoate metabolism_Homo sapiens_hsa006501.70045780
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65057321
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.63125127
30Fructose and mannose metabolism_Homo sapiens_hsa000511.39306700
31Spliceosome_Homo sapiens_hsa030401.37262822
32Cell cycle_Homo sapiens_hsa041101.32678454
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.29697711
34Fatty acid metabolism_Homo sapiens_hsa012121.25375436
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22004523
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17995801
37mRNA surveillance pathway_Homo sapiens_hsa030151.16009637
38Selenocompound metabolism_Homo sapiens_hsa004501.12452147
39Lysine degradation_Homo sapiens_hsa003101.03914115
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03302489
41Non-homologous end-joining_Homo sapiens_hsa034501.01404002
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98532096
43Pyruvate metabolism_Homo sapiens_hsa006200.94180019
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93568256
45p53 signaling pathway_Homo sapiens_hsa041150.89455032
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87676282
47Steroid biosynthesis_Homo sapiens_hsa001000.84334054
48Nitrogen metabolism_Homo sapiens_hsa009100.82896370
49RNA polymerase_Homo sapiens_hsa030200.79962766
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76681979
51Galactose metabolism_Homo sapiens_hsa000520.76166287
52Oocyte meiosis_Homo sapiens_hsa041140.75194071
53Pyrimidine metabolism_Homo sapiens_hsa002400.70301080
54Fatty acid degradation_Homo sapiens_hsa000710.70202684
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69516734
56Glutathione metabolism_Homo sapiens_hsa004800.68464093
57Starch and sucrose metabolism_Homo sapiens_hsa005000.67942721
58Proteasome_Homo sapiens_hsa030500.67739741
59Hedgehog signaling pathway_Homo sapiens_hsa043400.66715286
60Purine metabolism_Homo sapiens_hsa002300.64583223
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63191141
62Tryptophan metabolism_Homo sapiens_hsa003800.61492917
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58760629
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54468857
65HIF-1 signaling pathway_Homo sapiens_hsa040660.54341922
66beta-Alanine metabolism_Homo sapiens_hsa004100.52579394
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46105722
68Regulation of autophagy_Homo sapiens_hsa041400.45352393
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44947218
70Legionellosis_Homo sapiens_hsa051340.44893537
71Adherens junction_Homo sapiens_hsa045200.43773958
72Glucagon signaling pathway_Homo sapiens_hsa049220.40814789
73Olfactory transduction_Homo sapiens_hsa047400.40232896
74Thyroid cancer_Homo sapiens_hsa052160.39823286
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39384005
76Peroxisome_Homo sapiens_hsa041460.38170024
77Thyroid hormone synthesis_Homo sapiens_hsa049180.36803511
78Nicotine addiction_Homo sapiens_hsa050330.31472409
79Fatty acid biosynthesis_Homo sapiens_hsa000610.30528723
80Complement and coagulation cascades_Homo sapiens_hsa046100.28066248
81MicroRNAs in cancer_Homo sapiens_hsa052060.27575967
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25168685
83Metabolic pathways_Homo sapiens_hsa011000.24099304
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23553991
85ABC transporters_Homo sapiens_hsa020100.21508655
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20825164
87Wnt signaling pathway_Homo sapiens_hsa043100.19682544
88Dorso-ventral axis formation_Homo sapiens_hsa043200.18070094
89Arginine and proline metabolism_Homo sapiens_hsa003300.17517614
90Epstein-Barr virus infection_Homo sapiens_hsa051690.14879683
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.14657026
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13679213
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.12690999
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12327734
95GABAergic synapse_Homo sapiens_hsa047270.09585535
96FoxO signaling pathway_Homo sapiens_hsa040680.09323084
97Mineral absorption_Homo sapiens_hsa049780.08639898
98Histidine metabolism_Homo sapiens_hsa003400.06952250
99Basal cell carcinoma_Homo sapiens_hsa052170.06401049
100Morphine addiction_Homo sapiens_hsa050320.05700361

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