TASP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1respiratory chain complex IV assembly (GO:0008535)5.50671962
2cytochrome complex assembly (GO:0017004)5.11378195
3deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.80672724
4mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.61163181
5mitochondrial respiratory chain complex I assembly (GO:0032981)4.61163181
6NADH dehydrogenase complex assembly (GO:0010257)4.61163181
7regulation of mitochondrial translation (GO:0070129)4.45513108
8monoubiquitinated protein deubiquitination (GO:0035520)3.97129090
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.61392581
10negative regulation of transcription regulatory region DNA binding (GO:2000678)3.60225714
11deoxyribose phosphate biosynthetic process (GO:0046385)3.57569866
122-deoxyribonucleotide biosynthetic process (GO:0009265)3.57569866
13water-soluble vitamin biosynthetic process (GO:0042364)3.57282728
14centriole replication (GO:0007099)3.55839349
15exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53718823
16mitochondrial DNA replication (GO:0006264)3.51014517
17tRNA methylation (GO:0030488)3.46553209
18DNA deamination (GO:0045006)3.45840915
19replication fork processing (GO:0031297)3.45826690
20response to pheromone (GO:0019236)3.44518150
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41199499
22nucleobase biosynthetic process (GO:0046112)3.40403178
23rRNA modification (GO:0000154)3.37759343
24rRNA methylation (GO:0031167)3.32211611
25intraciliary transport (GO:0042073)3.29685790
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29678469
27DNA-dependent DNA replication (GO:0006261)3.26637536
28regulation of nuclear cell cycle DNA replication (GO:0033262)3.26106316
29RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.25783556
30regulation of mitotic spindle checkpoint (GO:1903504)3.24525297
31regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24525297
32mannosylation (GO:0097502)3.22016797
33microtubule depolymerization (GO:0007019)3.21098246
34telomere maintenance via semi-conservative replication (GO:0032201)3.20530106
35regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.18526564
36deoxyribonucleotide biosynthetic process (GO:0009263)3.18482516
37inositol phosphate catabolic process (GO:0071545)3.16171758
38oxidative phosphorylation (GO:0006119)3.14977491
39termination of RNA polymerase III transcription (GO:0006386)3.13208496
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.13208496
41inositol phosphate dephosphorylation (GO:0046855)3.11238656
42phosphorylated carbohydrate dephosphorylation (GO:0046838)3.11238656
43mitochondrial calcium ion transport (GO:0006851)3.08498318
44regulation of cellular amino acid metabolic process (GO:0006521)3.07987035
45maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.07177490
46purine nucleobase biosynthetic process (GO:0009113)3.04129898
47preassembly of GPI anchor in ER membrane (GO:0016254)3.03522583
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01097779
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01097779
50cullin deneddylation (GO:0010388)3.00133471
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99973014
52piRNA metabolic process (GO:0034587)2.99570397
53signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97808495
54signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97808495
55signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97808495
56signal peptide processing (GO:0006465)2.97458767
57GMP metabolic process (GO:0046037)2.97398748
58single strand break repair (GO:0000012)2.96502090
59ribosome biogenesis (GO:0042254)2.96092548
60regulation of acyl-CoA biosynthetic process (GO:0050812)2.95095180
61somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.94420029
62somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.94420029
63isotype switching (GO:0045190)2.94420029
64maturation of 5.8S rRNA (GO:0000460)2.93889753
65signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.93645753
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.93645753
67negative regulation of DNA-dependent DNA replication (GO:2000104)2.90740193
68DNA replication-independent nucleosome organization (GO:0034724)2.90275184
69DNA replication-independent nucleosome assembly (GO:0006336)2.90275184
70respiratory electron transport chain (GO:0022904)2.87401099
71platelet dense granule organization (GO:0060155)2.86698488
72electron transport chain (GO:0022900)2.86420778
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86000456
74pyrimidine-containing compound biosynthetic process (GO:0072528)2.85717226
75protein-cofactor linkage (GO:0018065)2.85207337
76deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.84914919
77mitotic nuclear envelope reassembly (GO:0007084)2.84476299
78nuclear envelope reassembly (GO:0031468)2.84476299
79synapsis (GO:0007129)2.84029076
80proteasome assembly (GO:0043248)2.83412887
81signal transduction involved in DNA damage checkpoint (GO:0072422)2.82511672
82signal transduction involved in DNA integrity checkpoint (GO:0072401)2.82511672
83protein deneddylation (GO:0000338)2.81756036
84energy coupled proton transport, down electrochemical gradient (GO:0015985)2.80873083
85ATP synthesis coupled proton transport (GO:0015986)2.80873083
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.80082803
87negative regulation of ligase activity (GO:0051352)2.80082803
88pteridine-containing compound biosynthetic process (GO:0042559)2.79182509
89telomere maintenance via telomerase (GO:0007004)2.78565417
90telomere maintenance via recombination (GO:0000722)2.77768195
91signal transduction involved in cell cycle checkpoint (GO:0072395)2.77739589
92binding of sperm to zona pellucida (GO:0007339)2.77168646
93sister chromatid cohesion (GO:0007062)2.77111863
94RNA methylation (GO:0001510)2.76625855
95negative regulation of thymocyte apoptotic process (GO:0070244)2.76601262
96axonemal dynein complex assembly (GO:0070286)2.76398310
97DNA synthesis involved in DNA repair (GO:0000731)2.76241433
98CENP-A containing nucleosome assembly (GO:0034080)2.75395258
99positive regulation of protein sumoylation (GO:0033235)2.75205566
100guanosine-containing compound biosynthetic process (GO:1901070)2.73219839
101acrosome reaction (GO:0007340)2.73064214
102spermatid development (GO:0007286)2.72000832
103positive regulation of histone H3-K4 methylation (GO:0051571)2.70831636
104C-terminal protein lipidation (GO:0006501)2.70748345
105histone H2A acetylation (GO:0043968)2.70212272
106positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.69821819
107calcium ion-dependent exocytosis (GO:0017156)2.69691369
108DNA catabolic process, exonucleolytic (GO:0000738)2.68629037
109positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.68352898
110motile cilium assembly (GO:0044458)2.67922277
111GDP-mannose metabolic process (GO:0019673)2.67487429
112maturation of SSU-rRNA (GO:0030490)2.67280526
113sperm-egg recognition (GO:0035036)2.65521230
114negative regulation of meiosis (GO:0045835)2.65377764
115aerobic respiration (GO:0009060)2.63084057
116male meiosis (GO:0007140)2.62340673
117DNA replication checkpoint (GO:0000076)2.62307739
118mitotic recombination (GO:0006312)2.61823535
119attachment of spindle microtubules to kinetochore (GO:0008608)2.60961110
120DNA strand elongation involved in DNA replication (GO:0006271)2.60448605
121DNA ligation (GO:0006266)2.60362053
122histone exchange (GO:0043486)2.59998431
123tRNA processing (GO:0008033)2.59787362
124chromatin remodeling at centromere (GO:0031055)2.59383797
125pyrimidine nucleoside biosynthetic process (GO:0046134)2.59193058
126ribosome assembly (GO:0042255)2.58556182
127viral mRNA export from host cell nucleus (GO:0046784)2.58313126
128telomere maintenance via telomere lengthening (GO:0010833)2.57565566
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.55767743
130sperm motility (GO:0030317)2.54820597
131regulation of sulfur metabolic process (GO:0042762)2.54760210
1327-methylguanosine mRNA capping (GO:0006370)2.54569301
133positive regulation of ligase activity (GO:0051351)2.54512997
134regulation of meiosis I (GO:0060631)2.54372901
135establishment of protein localization to mitochondrial membrane (GO:0090151)2.54193197
136lactate metabolic process (GO:0006089)2.54191345
137regulation of cofactor metabolic process (GO:0051193)2.53128961
138regulation of coenzyme metabolic process (GO:0051196)2.53128961
139positive regulation of osteoblast proliferation (GO:0033690)2.52877497
140DNA strand elongation (GO:0022616)2.51161445
141regulation of cilium movement (GO:0003352)2.50229523
142acrosome assembly (GO:0001675)2.50217947
143pyrimidine nucleotide biosynthetic process (GO:0006221)2.48428017
144transcription-coupled nucleotide-excision repair (GO:0006283)2.46108126
145protein complex biogenesis (GO:0070271)2.45666539
146meiotic nuclear division (GO:0007126)2.45482006
147pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.44942206
148pseudouridine synthesis (GO:0001522)2.44719721
149histone mRNA metabolic process (GO:0008334)2.41837887
1507-methylguanosine RNA capping (GO:0009452)2.41359674
151RNA capping (GO:0036260)2.41359674
152metallo-sulfur cluster assembly (GO:0031163)2.40965658
153iron-sulfur cluster assembly (GO:0016226)2.40965658
154cell-cell recognition (GO:0009988)2.40761386
155polyol catabolic process (GO:0046174)2.40651447
156protein maturation by protein folding (GO:0022417)2.40439738
157mitochondrial respiratory chain complex assembly (GO:0033108)2.39675043
158transcription elongation from RNA polymerase I promoter (GO:0006362)2.39481451
159viral protein processing (GO:0019082)2.38818812
160peptidyl-histidine modification (GO:0018202)2.38750693
161DNA replication initiation (GO:0006270)2.38701933
162telomere organization (GO:0032200)2.38622731
163telomere maintenance (GO:0000723)2.38599100
164postreplication repair (GO:0006301)2.38069142
165negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.37813795
166regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.35773540
167epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.34995415
168organelle disassembly (GO:1903008)2.34690639
169mitotic metaphase plate congression (GO:0007080)2.34528076
170polyamine biosynthetic process (GO:0006596)2.33415402
171oocyte maturation (GO:0001556)2.32947894
172cilium or flagellum-dependent cell motility (GO:0001539)2.32360870
173synaptonemal complex assembly (GO:0007130)2.32088903
174positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.31177128
175DNA double-strand break processing (GO:0000729)2.30320897
176translesion synthesis (GO:0019985)2.30102567
177mitochondrial DNA metabolic process (GO:0032042)2.29286568
178snRNA processing (GO:0016180)2.29007299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.27226243
2E2F7_22180533_ChIP-Seq_HELA_Human4.27218027
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.38715058
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31136276
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.28255830
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13045711
7* GABP_17652178_ChIP-ChIP_JURKAT_Human3.11848451
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.99077701
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.79997736
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66640353
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.64522621
12VDR_23849224_ChIP-Seq_CD4+_Human2.59984261
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.58885718
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.51484232
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51459549
16ZNF274_21170338_ChIP-Seq_K562_Hela2.40948314
17* NOTCH1_21737748_ChIP-Seq_TLL_Human2.39193249
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.36792887
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31004025
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.25090126
21VDR_22108803_ChIP-Seq_LS180_Human2.16729389
22ELK1_19687146_ChIP-ChIP_HELA_Human2.11319567
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08043419
24FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.07548281
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07247392
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.06115819
27FOXP3_21729870_ChIP-Seq_TREG_Human2.05427248
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.04667850
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04288725
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.03287244
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00786725
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94865366
33DCP1A_22483619_ChIP-Seq_HELA_Human1.94599129
34IGF1R_20145208_ChIP-Seq_DFB_Human1.90745422
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90166159
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.88808194
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78949933
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72914942
39* GABP_19822575_ChIP-Seq_HepG2_Human1.71279315
40* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59969297
41* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58289925
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58185311
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57073295
44* SRF_21415370_ChIP-Seq_HL-1_Mouse1.54971700
45P300_19829295_ChIP-Seq_ESCs_Human1.53914816
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53716023
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.53225034
48GATA1_22025678_ChIP-Seq_K562_Human1.53083912
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52697797
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47985858
51* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46906095
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46483061
53* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.46009752
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43599375
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41728860
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41466643
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39353967
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38874860
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.37448627
60GBX2_23144817_ChIP-Seq_PC3_Human1.36999531
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36936739
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36647317
63* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36130762
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35400117
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34194228
66XRN2_22483619_ChIP-Seq_HELA_Human1.33599818
67FUS_26573619_Chip-Seq_HEK293_Human1.30796108
68ER_23166858_ChIP-Seq_MCF-7_Human1.29583422
69IRF1_19129219_ChIP-ChIP_H3396_Human1.27245423
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25708896
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25013916
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.24340513
73TP53_22573176_ChIP-Seq_HFKS_Human1.23215188
74* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22243599
75TAF15_26573619_Chip-Seq_HEK293_Human1.22039070
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21359451
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20922485
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18588950
79HTT_18923047_ChIP-ChIP_STHdh_Human1.17995434
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17761021
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17621054
82CBP_20019798_ChIP-Seq_JUKART_Human1.17621054
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15896594
84MYC_18940864_ChIP-ChIP_HL60_Human1.12877944
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12335305
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12287763
87TTF2_22483619_ChIP-Seq_HELA_Human1.12208903
88ELF5_23300383_ChIP-Seq_T47D_Human1.11272922
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10542894
90* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08948786
91EWS_26573619_Chip-Seq_HEK293_Human1.08114666
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08014118
93CIITA_25753668_ChIP-Seq_RAJI_Human1.07820538
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07661867
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07085607
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.07085607
97NANOG_19829295_ChIP-Seq_ESCs_Human1.05642601
98SOX2_19829295_ChIP-Seq_ESCs_Human1.05642601
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04131124
100E2F1_21310950_ChIP-Seq_MCF-7_Human1.03126337
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02942524
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02851716
103TCF4_22108803_ChIP-Seq_LS180_Human1.02485934
104FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02122035
105SALL4_22934838_ChIP-ChIP_CD34+_Human1.01543551
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01280686
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00382388
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00160641
109CRX_20693478_ChIP-Seq_RETINA_Mouse0.99354177
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98874199
111* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98825770
112EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98812346
113IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98313486
114ELK1_22589737_ChIP-Seq_MCF10A_Human0.98242814
115SMAD4_21799915_ChIP-Seq_A2780_Human0.97686280
116KDM5A_27292631_Chip-Seq_BREAST_Human0.95525759
117* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95432991
118TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94675313
119POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94383920
120ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93832583
121* P53_22387025_ChIP-Seq_ESCs_Mouse0.92871387
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91815895
123* STAT3_18555785_Chip-Seq_ESCs_Mouse0.91625263
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90355508
125SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90306202
126* NMYC_18555785_Chip-Seq_ESCs_Mouse0.90096750
127* NANOG_18555785_Chip-Seq_ESCs_Mouse0.89061906
128EZH2_27294783_Chip-Seq_NPCs_Mouse0.86718281
129REST_21632747_ChIP-Seq_MESCs_Mouse0.85603246
130* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85098955
131CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84497054
132EGR1_19374776_ChIP-ChIP_THP-1_Human0.83660354
133* SOX2_18555785_Chip-Seq_ESCs_Mouse0.83595474
134TP63_19390658_ChIP-ChIP_HaCaT_Human0.83475441
135* P300_18555785_Chip-Seq_ESCs_Mouse0.83191573
136* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83020975
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82996703
138REST_19997604_ChIP-ChIP_NEURONS_Mouse0.82776450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002132_abnormal_respiratory_system4.29601087
2MP0003693_abnormal_embryo_hatching3.21798703
3MP0008877_abnormal_DNA_methylation3.07197043
4MP0008058_abnormal_DNA_repair3.06614410
5MP0010094_abnormal_chromosome_stability2.96927801
6MP0005084_abnormal_gallbladder_morpholo2.94309442
7MP0003195_calcinosis2.54278719
8MP0003718_maternal_effect2.52211618
9MP0003787_abnormal_imprinting2.50267509
10MP0008057_abnormal_DNA_replication2.46922756
11MP0005410_abnormal_fertilization2.45054844
12MP0008872_abnormal_physiological_respon2.44097179
13MP0005075_abnormal_melanosome_morpholog2.43233655
14MP0005671_abnormal_response_to2.39335187
15MP0002009_preneoplasia2.31249788
16MP0004957_abnormal_blastocyst_morpholog2.27949891
17MP0003763_abnormal_thymus_physiology2.27035639
18MP0005423_abnormal_somatic_nervous2.17517696
19MP0001986_abnormal_taste_sensitivity2.17144186
20MP0006292_abnormal_olfactory_placode2.12044392
21MP0002938_white_spotting2.11568142
22MP0003880_abnormal_central_pattern2.10823467
23MP0002160_abnormal_reproductive_system2.04475916
24MP0001929_abnormal_gametogenesis1.98075931
25MP0003111_abnormal_nucleus_morphology1.95652219
26MP0001188_hyperpigmentation1.94432122
27MP0003077_abnormal_cell_cycle1.93174656
28MP0006035_abnormal_mitochondrial_morpho1.85661088
29MP0008007_abnormal_cellular_replicative1.83570079
30MP0001984_abnormal_olfaction1.80652979
31MP0008875_abnormal_xenobiotic_pharmacok1.78575877
32MP0010386_abnormal_urinary_bladder1.76799187
33MP0001661_extended_life_span1.74899320
34MP0003635_abnormal_synaptic_transmissio1.74157948
35MP0000015_abnormal_ear_pigmentation1.73690522
36MP0005646_abnormal_pituitary_gland1.72368270
37MP0003698_abnormal_male_reproductive1.64567644
38MP0002102_abnormal_ear_morphology1.60916116
39MP0006276_abnormal_autonomic_nervous1.57614857
40MP0005171_absent_coat_pigmentation1.56312883
41MP0002210_abnormal_sex_determination1.56175901
42MP0005389_reproductive_system_phenotype1.56078746
43MP0003183_abnormal_peptide_metabolism1.55434008
44MP0002837_dystrophic_cardiac_calcinosis1.54679133
45MP0002396_abnormal_hematopoietic_system1.53038914
46MP0002638_abnormal_pupillary_reflex1.51693361
47MP0009046_muscle_twitch1.51305656
48MP0004885_abnormal_endolymph1.49590658
49MP0001545_abnormal_hematopoietic_system1.49539993
50MP0005397_hematopoietic_system_phenotyp1.49539993
51MP0003252_abnormal_bile_duct1.47730915
52MP0000013_abnormal_adipose_tissue1.47469039
53MP0002693_abnormal_pancreas_physiology1.45130535
54MP0003186_abnormal_redox_activity1.44794027
55MP0009745_abnormal_behavioral_response1.43135394
56MP0005379_endocrine/exocrine_gland_phen1.42755765
57MP0004859_abnormal_synaptic_plasticity1.42592871
58MP0001529_abnormal_vocalization1.42339959
59MP0002063_abnormal_learning/memory/cond1.41253935
60MP0008995_early_reproductive_senescence1.40461951
61MP0001968_abnormal_touch/_nociception1.40113433
62MP0000569_abnormal_digit_pigmentation1.39664982
63MP0003786_premature_aging1.39566497
64MP0003890_abnormal_embryonic-extraembry1.39545487
65MP0002163_abnormal_gland_morphology1.39150948
66MP0004147_increased_porphyrin_level1.38421120
67MP0001919_abnormal_reproductive_system1.38143391
68MP0003121_genomic_imprinting1.35145921
69MP0006072_abnormal_retinal_apoptosis1.34804896
70MP0002572_abnormal_emotion/affect_behav1.34758667
71MP0003123_paternal_imprinting1.33293501
72MP0001145_abnormal_male_reproductive1.31985955
73MP0005636_abnormal_mineral_homeostasis1.30632228
74MP0002166_altered_tumor_susceptibility1.29190559
75MP0005408_hypopigmentation1.28206475
76MP0001501_abnormal_sleep_pattern1.26571529
77MP0002095_abnormal_skin_pigmentation1.25305951
78MP0000653_abnormal_sex_gland1.24857233
79MP0003950_abnormal_plasma_membrane1.24752069
80MP0005220_abnormal_exocrine_pancreas1.22460118
81MP0003806_abnormal_nucleotide_metabolis1.21419314
82MP0005310_abnormal_salivary_gland1.21126696
83MP0003879_abnormal_hair_cell1.20963368
84MP0004808_abnormal_hematopoietic_stem1.19966167
85* MP0002398_abnormal_bone_marrow1.19404926
86MP0009697_abnormal_copulation1.18668816
87MP0001485_abnormal_pinna_reflex1.16562873
88MP0009780_abnormal_chondrocyte_physiolo1.15124324
89* MP0000703_abnormal_thymus_morphology1.12849942
90MP0002735_abnormal_chemical_nociception1.10831916
91MP0005551_abnormal_eye_electrophysiolog1.09893837
92MP0009333_abnormal_splenocyte_physiolog1.09336794
93MP0000372_irregular_coat_pigmentation1.08995617
94MP0002006_tumorigenesis1.08693732
95MP0002064_seizures1.07980987
96MP0002876_abnormal_thyroid_physiology1.07940021
97MP0002272_abnormal_nervous_system1.06903623
98MP0005174_abnormal_tail_pigmentation1.06902078
99MP0005332_abnormal_amino_acid1.05960335
100MP0001502_abnormal_circadian_rhythm1.05470929
101MP0005645_abnormal_hypothalamus_physiol1.04138527
102MP0002877_abnormal_melanocyte_morpholog1.03927944
103MP0006036_abnormal_mitochondrial_physio1.03376163
104MP0003136_yellow_coat_color1.02371211
105MP0000358_abnormal_cell_content/1.01127341
106MP0005395_other_phenotype1.00862783
107MP0002234_abnormal_pharynx_morphology0.98715003
108MP0002928_abnormal_bile_duct0.98276027
109MP0001944_abnormal_pancreas_morphology0.96764661
110MP0000631_abnormal_neuroendocrine_gland0.94317001
111MP0000427_abnormal_hair_cycle0.94293188
112MP0001764_abnormal_homeostasis0.94227009
113MP0000678_abnormal_parathyroid_gland0.93306253
114MP0004270_analgesia0.93135959
115MP0002909_abnormal_adrenal_gland0.92430271
116MP0002161_abnormal_fertility/fecundity0.92243474
117MP0008932_abnormal_embryonic_tissue0.90126787
118MP0002734_abnormal_mechanical_nocicepti0.89622858
119MP0005409_darkened_coat_color0.88066368
120MP0000689_abnormal_spleen_morphology0.86705394
121* MP0002722_abnormal_immune_system0.85915482
122MP0001970_abnormal_pain_threshold0.85609342
123MP0002184_abnormal_innervation0.84635525
124MP0001119_abnormal_female_reproductive0.83640035
125MP0000681_abnormal_thyroid_gland0.83153120
126MP0002822_catalepsy0.82501083
127MP0002733_abnormal_thermal_nociception0.82498263
128MP0010678_abnormal_skin_adnexa0.82370798
129MP0005499_abnormal_olfactory_system0.81883214
130MP0005394_taste/olfaction_phenotype0.81883214
131MP0005253_abnormal_eye_physiology0.81736230
132MP0002736_abnormal_nociception_after0.81304223
133MP0008789_abnormal_olfactory_epithelium0.77127960
134MP0001905_abnormal_dopamine_level0.75843783
135MP0001666_abnormal_nutrient_absorption0.74830092
136MP0008770_decreased_survivor_rate0.74368916
137MP0004043_abnormal_pH_regulation0.72964352
138MP0000647_abnormal_sebaceous_gland0.71054480
139MP0004142_abnormal_muscle_tone0.70652216
140MP0002090_abnormal_vision0.70550440
141MP0001324_abnormal_eye_pigmentation0.68471608
142MP0000383_abnormal_hair_follicle0.66761614
143MP0004215_abnormal_myocardial_fiber0.65315789
144MP0003943_abnormal_hepatobiliary_system0.64880209
145MP0005377_hearing/vestibular/ear_phenot0.62858866
146MP0003878_abnormal_ear_physiology0.62858866
147MP0008961_abnormal_basal_metabolism0.62636494
148MP0008873_increased_physiological_sensi0.61273172
149MP0000313_abnormal_cell_death0.59773286

Predicted human phenotypes

RankGene SetZ-score
1Short middle phalanx of the 5th finger (HP:0004220)4.81229138
2Mitochondrial inheritance (HP:0001427)4.44113484
3Increased CSF lactate (HP:0002490)4.38691935
4Hepatocellular necrosis (HP:0001404)4.23923716
5Acute encephalopathy (HP:0006846)4.14936010
6Hepatic necrosis (HP:0002605)3.81069339
7Birth length less than 3rd percentile (HP:0003561)3.59541733
8Medial flaring of the eyebrow (HP:0010747)3.47648988
9Pancreatic cysts (HP:0001737)3.46813421
10Pancreatic fibrosis (HP:0100732)3.45548368
11Absent/shortened dynein arms (HP:0200106)3.40538389
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.40538389
13Renal Fanconi syndrome (HP:0001994)3.31787939
14Congenital primary aphakia (HP:0007707)3.28753817
15Acanthocytosis (HP:0001927)3.27180027
16Gait imbalance (HP:0002141)3.21212087
17Abnormal respiratory motile cilium morphology (HP:0005938)3.20170050
18Abnormal respiratory epithelium morphology (HP:0012253)3.20170050
19Increased hepatocellular lipid droplets (HP:0006565)3.19588564
20Cerebral edema (HP:0002181)3.17772196
21Nephrogenic diabetes insipidus (HP:0009806)3.14447249
22Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.11800238
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.08699941
24Aplastic anemia (HP:0001915)3.07424027
25Febrile seizures (HP:0002373)2.94285085
26Lipid accumulation in hepatocytes (HP:0006561)2.89758520
27Abnormality of the heme biosynthetic pathway (HP:0010472)2.83417465
28Methylmalonic acidemia (HP:0002912)2.83197859
29Brushfield spots (HP:0001088)2.81146116
30Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.77557988
31Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.74296424
32Molar tooth sign on MRI (HP:0002419)2.65935773
33Abnormality of midbrain morphology (HP:0002418)2.65935773
34Respiratory failure (HP:0002878)2.64279264
35Rhinitis (HP:0012384)2.59475419
36Increased serum lactate (HP:0002151)2.56371468
37Progressive inability to walk (HP:0002505)2.51402800
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.48039135
39Abnormality of the phalanges of the 5th finger (HP:0004213)2.47857737
40True hermaphroditism (HP:0010459)2.46293576
41Focal motor seizures (HP:0011153)2.43455408
42Abnormality of chromosome stability (HP:0003220)2.42606998
43Chromsome breakage (HP:0040012)2.41009746
44Abnormality of the preputium (HP:0100587)2.38763246
45Poor coordination (HP:0002370)2.37291637
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36865963
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36865963
48Lactic acidosis (HP:0003128)2.35619843
49Impaired smooth pursuit (HP:0007772)2.34692336
50Optic disc pallor (HP:0000543)2.34189536
51Myelodysplasia (HP:0002863)2.33647853
52Hyperinsulinemic hypoglycemia (HP:0000825)2.33158682
53Petechiae (HP:0000967)2.32620748
54Methylmalonic aciduria (HP:0012120)2.31413584
55Abnormal respiratory motile cilium physiology (HP:0012261)2.30261022
56Inability to walk (HP:0002540)2.30090159
57Abnormality of the duodenum (HP:0002246)2.28602260
58IgM deficiency (HP:0002850)2.28070300
59Abnormality of the renal medulla (HP:0100957)2.27567699
60Abnormality of renal resorption (HP:0011038)2.25288639
61Abnormality of the renal cortex (HP:0011035)2.24491641
62Acute necrotizing encephalopathy (HP:0006965)2.24396487
63Nephronophthisis (HP:0000090)2.24014139
64Large for gestational age (HP:0001520)2.23999867
65Impulsivity (HP:0100710)2.22022837
66CNS demyelination (HP:0007305)2.21938805
67Abnormal spermatogenesis (HP:0008669)2.21350564
68Abnormal rod and cone electroretinograms (HP:0008323)2.19034414
69Thyroiditis (HP:0100646)2.19012821
70Abnormality of the pons (HP:0007361)2.18478464
71Abnormality of dental color (HP:0011073)2.18246373
72Severe combined immunodeficiency (HP:0004430)2.17507976
73Chronic hepatic failure (HP:0100626)2.16536124
74Facial cleft (HP:0002006)2.16296537
75Dysautonomia (HP:0002459)2.15986672
76Bony spicule pigmentary retinopathy (HP:0007737)2.13427135
77Protruding tongue (HP:0010808)2.13407010
78Hypoplasia of the thymus (HP:0000778)2.12495817
79Abnormal mitochondria in muscle tissue (HP:0008316)2.12265711
80Severe visual impairment (HP:0001141)2.11905368
81Hypoplasia of the pons (HP:0012110)2.10901822
82Abnormality of alanine metabolism (HP:0010916)2.09163303
83Hyperalaninemia (HP:0003348)2.09163303
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09163303
85Aplasia/Hypoplasia of the uvula (HP:0010293)2.08874262
86Aplasia/hypoplasia of the uterus (HP:0008684)2.08867206
87Pancytopenia (HP:0001876)2.08837188
88Meckel diverticulum (HP:0002245)2.08527615
89Lethargy (HP:0001254)2.07915239
90Genital tract atresia (HP:0001827)2.07756164
91Abnormality of B cell number (HP:0010975)2.07728244
92B lymphocytopenia (HP:0010976)2.07728244
93Hypothermia (HP:0002045)2.07289844
94Vaginal atresia (HP:0000148)2.07131017
95Median cleft lip (HP:0000161)2.05526298
96Abnormal number of erythroid precursors (HP:0012131)2.05324293
97Abnormality of vitamin B metabolism (HP:0004340)2.03339399
98Short 5th finger (HP:0009237)2.03217782
99Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02099032
100Chronic sinusitis (HP:0011109)2.00106107
101Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99430306
102IgG deficiency (HP:0004315)1.97850882
103Aganglionic megacolon (HP:0002251)1.97389091
104Abnormality of the ileum (HP:0001549)1.96625306
105Renal cortical cysts (HP:0000803)1.95598473
106Leukodystrophy (HP:0002415)1.94763532
107Aplasia/Hypoplasia of the tongue (HP:0010295)1.94546499
108Exercise intolerance (HP:0003546)1.93953883
109Type I transferrin isoform profile (HP:0003642)1.93752190
110Abnormality of methionine metabolism (HP:0010901)1.93652040
111Ragged-red muscle fibers (HP:0003200)1.90243212
112Chronic bronchitis (HP:0004469)1.90014159
113Proximal tubulopathy (HP:0000114)1.89497760
114Abnormal ciliary motility (HP:0012262)1.89091184
115Thrombocytosis (HP:0001894)1.88282321
116Respiratory difficulties (HP:0002880)1.87388692
117Bronchitis (HP:0012387)1.87372256
118Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.86431635
119Hypoplastic iliac wings (HP:0002866)1.85896091
120Prominent metopic ridge (HP:0005487)1.85616855
121Recurrent bronchitis (HP:0002837)1.85610988
122Atonic seizures (HP:0010819)1.85454465
123Progressive macrocephaly (HP:0004481)1.85381618
124Abnormality of cells of the erythroid lineage (HP:0012130)1.85217170
125Abnormality of the labia minora (HP:0012880)1.83560935
126Visual hallucinations (HP:0002367)1.81515734
127Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80564494
128Bone marrow hypocellularity (HP:0005528)1.80276510
129Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79968091
130Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79857150
131Abnormal protein N-linked glycosylation (HP:0012347)1.79857150
132Abnormal protein glycosylation (HP:0012346)1.79857150
133Abnormal glycosylation (HP:0012345)1.79857150
134Decreased testicular size (HP:0008734)1.79510034
135Constricted visual fields (HP:0001133)1.79215585
136Hypoplasia of the uterus (HP:0000013)1.78919376
137Hypoproteinemia (HP:0003075)1.78818338
138Dyschromatopsia (HP:0007641)1.78558351
139Clubbing of toes (HP:0100760)1.78556996
140Abnormality of the anterior horn cell (HP:0006802)1.78421540
141Degeneration of anterior horn cells (HP:0002398)1.78421540
1423-Methylglutaconic aciduria (HP:0003535)1.78092750
143Duodenal stenosis (HP:0100867)1.77836192
144Small intestinal stenosis (HP:0012848)1.77836192
145Abnormality of ocular smooth pursuit (HP:0000617)1.77833645
146Abnormality of the vitamin B12 metabolism (HP:0004341)1.77794237
147Abnormality of the carotid arteries (HP:0005344)1.77555754
148Progressive muscle weakness (HP:0003323)1.77426411
149Volvulus (HP:0002580)1.77251218
150Aplasia/Hypoplasia of the fovea (HP:0008060)1.76762957
151Hypoplasia of the fovea (HP:0007750)1.76762957
152Absent eyebrow (HP:0002223)1.75955032
15311 pairs of ribs (HP:0000878)1.75704029
154Truncal ataxia (HP:0002078)1.75435924
155Broad palm (HP:0001169)1.75298268
156Cystic liver disease (HP:0006706)1.75213964
157Exertional dyspnea (HP:0002875)1.75192035
158Combined immunodeficiency (HP:0005387)1.74775224
159Oculomotor apraxia (HP:0000657)1.74427635
160Self-mutilation (HP:0000742)1.74412963
161Bronchiectasis (HP:0002110)1.73475934
162Abnormal biliary tract physiology (HP:0012439)1.71110149
163Bile duct proliferation (HP:0001408)1.71110149
164Intestinal atresia (HP:0011100)1.68734128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.86257428
2STK163.85330214
3TXK3.24862421
4MAP3K123.01437971
5ACVR1B2.84085150
6NUAK12.55941683
7WEE12.46002428
8MAP4K22.36005378
9BUB12.35157381
10CASK2.23990316
11MAP2K72.21800621
12CCNB12.18524355
13SRPK12.15092026
14VRK12.13142992
15VRK22.11590357
16PASK1.98355218
17FRK1.96906785
18BMPR1B1.95659980
19AKT31.92115009
20ZAK1.88296812
21PDK31.88030303
22PDK41.88030303
23PLK41.86412408
24CDC71.85316947
25STK391.75318430
26BRSK21.69381588
27SIK31.69343228
28NTRK31.65590291
29TSSK61.63685497
30CAMKK21.61734218
31DAPK11.59267313
32BCKDK1.56876393
33MAP4K11.53844750
34ADRBK21.53545025
35PLK31.53441539
36OXSR11.50678941
37STK38L1.49368155
38TAOK31.47501482
39TRIM281.45617086
40MKNK11.43177011
41TNIK1.43078329
42EIF2AK31.41433778
43PLK21.41204543
44MAP3K41.34157466
45BRSK11.32182671
46PBK1.28345441
47NLK1.23641940
48BRAF1.22272047
49CDK121.15761325
50WNK41.15685524
51NEK21.14691702
52STK31.14384865
53PLK11.12836937
54ZAP701.08617067
55TESK11.00753460
56YES10.97066189
57PINK10.96575383
58GRK10.94700470
59NME10.94131740
60BRD40.93554611
61CSNK1G10.92440321
62CHEK20.92369345
63FER0.92228827
64TNK20.92173054
65ATR0.87170405
66PDK20.85540625
67PRKCI0.85213290
68MINK10.83795444
69ERBB30.83372139
70MAP2K60.82970741
71BCR0.82298791
72PRPF4B0.82070117
73BMPR20.81344666
74PHKG20.80368305
75PHKG10.80368305
76TEC0.77925417
77STK40.76158658
78PRKCE0.75213298
79AURKB0.74556887
80RIPK40.73844109
81PAK30.71410079
82CDK80.70151397
83SYK0.70103949
84TAOK20.70092409
85TRPM70.70000183
86CLK10.69510215
87AURKA0.67525854
88SGK20.66571007
89TAF10.64995434
90LMTK20.63935748
91GRK50.63546633
92WNK30.63172081
93MAP2K30.61994920
94EPHA40.61756652
95TLK10.61546596
96PRKCG0.61385892
97CSNK1G30.60539840
98MAP2K40.58472038
99RPS6KA50.57509195
100MAPKAPK50.56071234
101JAK30.55132103
102DYRK1A0.54766248
103PRKCQ0.54214226
104FLT30.53391894
105CSNK1G20.52250642
106MKNK20.51643011
107RPS6KB20.50685744
108KIT0.50219819
109SCYL20.50087608
110RPS6KB10.50014315
111EIF2AK10.49859952
112IRAK30.48795862
113CAMKK10.48633296
114LCK0.48600818
115TTK0.48518500
116MAPKAPK30.47928597
117NTRK20.47889384
118DYRK30.47853839
119MAPK130.47768753
120CDK30.46962702
121CSNK1A1L0.46304044
122FGFR10.46120075
123EPHA30.45053547
124MAP3K110.44157207
125ARAF0.44035837
126SIK20.43128671
127MAP3K140.42774168
128NEK60.42199560
129FGFR20.41834701
130CHEK10.40392819
131CDK70.40229672
132MARK30.37128807
133EIF2AK20.35522338
134PNCK0.35248361
135INSRR0.34918789
136CSNK2A10.34416688
137NEK10.34057853
138MAP3K90.33537618
139CSNK2A20.33366143
140ADRBK10.32182274
141MARK10.32106264
142GRK60.32049142
143IRAK40.31758197
144MYLK0.30858374
145ATM0.30021648

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.10623805
2Mismatch repair_Homo sapiens_hsa034303.04111725
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93678488
4Protein export_Homo sapiens_hsa030602.92792521
5Homologous recombination_Homo sapiens_hsa034402.87727019
6RNA polymerase_Homo sapiens_hsa030202.79732760
7Proteasome_Homo sapiens_hsa030502.59882734
8Pyrimidine metabolism_Homo sapiens_hsa002402.59587278
9Nicotine addiction_Homo sapiens_hsa050332.13919844
10Nucleotide excision repair_Homo sapiens_hsa034202.09890645
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07612437
12Fanconi anemia pathway_Homo sapiens_hsa034602.05335500
13RNA transport_Homo sapiens_hsa030132.02653972
14Propanoate metabolism_Homo sapiens_hsa006401.93523646
15Spliceosome_Homo sapiens_hsa030401.80080560
16Non-homologous end-joining_Homo sapiens_hsa034501.74844637
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74840858
18Butanoate metabolism_Homo sapiens_hsa006501.70247516
19Purine metabolism_Homo sapiens_hsa002301.69553400
20Phototransduction_Homo sapiens_hsa047441.67796032
21Synaptic vesicle cycle_Homo sapiens_hsa047211.62587337
22Cell cycle_Homo sapiens_hsa041101.58855605
23Basal transcription factors_Homo sapiens_hsa030221.55523064
24RNA degradation_Homo sapiens_hsa030181.52814906
25Collecting duct acid secretion_Homo sapiens_hsa049661.52186663
26Base excision repair_Homo sapiens_hsa034101.51446272
27Ribosome_Homo sapiens_hsa030101.48747924
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48361046
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.48218156
30Amphetamine addiction_Homo sapiens_hsa050311.44196337
31Taste transduction_Homo sapiens_hsa047421.37251805
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36642785
33Oocyte meiosis_Homo sapiens_hsa041141.33621399
34Peroxisome_Homo sapiens_hsa041461.33080141
35Caffeine metabolism_Homo sapiens_hsa002321.30895697
36Selenocompound metabolism_Homo sapiens_hsa004501.29109288
37Morphine addiction_Homo sapiens_hsa050321.29077666
38Vibrio cholerae infection_Homo sapiens_hsa051101.26041516
39Fatty acid elongation_Homo sapiens_hsa000621.24510293
40Olfactory transduction_Homo sapiens_hsa047401.21660928
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.21576930
42Long-term potentiation_Homo sapiens_hsa047201.20811103
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20383498
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15528370
45Oxidative phosphorylation_Homo sapiens_hsa001901.12380737
46Type I diabetes mellitus_Homo sapiens_hsa049401.12014928
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11995418
48Primary immunodeficiency_Homo sapiens_hsa053401.11345587
49Alcoholism_Homo sapiens_hsa050341.09899550
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09412081
51mRNA surveillance pathway_Homo sapiens_hsa030151.08352403
52N-Glycan biosynthesis_Homo sapiens_hsa005101.06619885
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06063459
54Glutathione metabolism_Homo sapiens_hsa004801.04096834
55Insulin secretion_Homo sapiens_hsa049111.03183636
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01345135
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99615073
58Huntingtons disease_Homo sapiens_hsa050160.98414489
59Pyruvate metabolism_Homo sapiens_hsa006200.97016447
60Circadian entrainment_Homo sapiens_hsa047130.96865922
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96229214
62Dopaminergic synapse_Homo sapiens_hsa047280.95274398
63p53 signaling pathway_Homo sapiens_hsa041150.94821596
64Linoleic acid metabolism_Homo sapiens_hsa005910.92872706
65Tryptophan metabolism_Homo sapiens_hsa003800.91840561
66Vitamin B6 metabolism_Homo sapiens_hsa007500.91600130
67Systemic lupus erythematosus_Homo sapiens_hsa053220.91428175
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91418885
69Nitrogen metabolism_Homo sapiens_hsa009100.89140897
70Epstein-Barr virus infection_Homo sapiens_hsa051690.89007080
71Chemical carcinogenesis_Homo sapiens_hsa052040.88925045
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.88521777
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87489235
74T cell receptor signaling pathway_Homo sapiens_hsa046600.87307834
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86615407
76GABAergic synapse_Homo sapiens_hsa047270.84728389
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84463346
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83406034
79Ether lipid metabolism_Homo sapiens_hsa005650.83403104
80Serotonergic synapse_Homo sapiens_hsa047260.81842639
81Allograft rejection_Homo sapiens_hsa053300.81198048
82Parkinsons disease_Homo sapiens_hsa050120.80507082
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77587310
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73672655
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72936842
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.71614753
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.71484152
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71363259
89Steroid biosynthesis_Homo sapiens_hsa001000.70541280
90Fatty acid metabolism_Homo sapiens_hsa012120.69149382
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68472403
92Alzheimers disease_Homo sapiens_hsa050100.65757385
93Retinol metabolism_Homo sapiens_hsa008300.65377644
94beta-Alanine metabolism_Homo sapiens_hsa004100.63467661
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62546327
96Autoimmune thyroid disease_Homo sapiens_hsa053200.62545519
97Pentose phosphate pathway_Homo sapiens_hsa000300.62052988
98Glutamatergic synapse_Homo sapiens_hsa047240.61689423
99Fatty acid degradation_Homo sapiens_hsa000710.60296628
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58708553
101One carbon pool by folate_Homo sapiens_hsa006700.58477692
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58084065
103Regulation of autophagy_Homo sapiens_hsa041400.57592094
104Circadian rhythm_Homo sapiens_hsa047100.56990347
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55962174
106Cholinergic synapse_Homo sapiens_hsa047250.54954000
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54453240
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54435665
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54195871
110Carbon metabolism_Homo sapiens_hsa012000.53547877
111Legionellosis_Homo sapiens_hsa051340.51771220
112Cardiac muscle contraction_Homo sapiens_hsa042600.51007745
113Cocaine addiction_Homo sapiens_hsa050300.50524016
114Rheumatoid arthritis_Homo sapiens_hsa053230.50380869
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49298181
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47137829
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45776847
118Antigen processing and presentation_Homo sapiens_hsa046120.45050234
119Inositol phosphate metabolism_Homo sapiens_hsa005620.44126194
120Fructose and mannose metabolism_Homo sapiens_hsa000510.43744820
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.43525865
122Measles_Homo sapiens_hsa051620.42791933
123Sulfur metabolism_Homo sapiens_hsa009200.41108075
124Herpes simplex infection_Homo sapiens_hsa051680.41029586
125Arachidonic acid metabolism_Homo sapiens_hsa005900.40936490
126Fat digestion and absorption_Homo sapiens_hsa049750.39980854
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39154172
128Viral carcinogenesis_Homo sapiens_hsa052030.38782668
129Tyrosine metabolism_Homo sapiens_hsa003500.38644972
130Asthma_Homo sapiens_hsa053100.38298612
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35823854
132Calcium signaling pathway_Homo sapiens_hsa040200.35673767
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31544842
134Folate biosynthesis_Homo sapiens_hsa007900.31273353
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31194077
136Glucagon signaling pathway_Homo sapiens_hsa049220.30553068
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28541304
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27403144
139Renin secretion_Homo sapiens_hsa049240.25700387
140Metabolic pathways_Homo sapiens_hsa011000.24766932
141HTLV-I infection_Homo sapiens_hsa051660.24333676
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24221143
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23999602
144Pancreatic secretion_Homo sapiens_hsa049720.23849723
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.23830023
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22510435

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